Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N924 2.922548
2R:R:F925 4.78449
3R:R:L928 4.4275409
4R:R:M929 3.906599
5R:R:T949 4.29448
6R:R:I953 4.35549
7R:R:S956 3.505449
8R:R:L960 3.615449
9R:R:F970 6.014198
10R:R:L973 2.725198
11R:R:R977 7.88754159
12R:R:N978 4.5075409
13R:R:H981 6.5354159
14R:R:Q1004 5.4325404
15R:R:F1017 2.89408
16R:R:W1025 7.185679
17R:R:M1026 3.14408
18R:R:E1029 7.54254159
19R:R:Q1032 3.9075408
20R:R:Y1034 7.9225408
21R:R:F1041 4.836559
22R:R:R1048 4.21474
23R:R:Y1056 3.6225479
24R:R:P1059 2.964509
25R:R:Y1074 3.885129
26R:R:L1082 5.4254128
27R:R:F1088 6.425128
28R:R:S1091 4.63754129
29R:R:I1093 3.794508
30R:R:L1107 2.0025168
31R:R:K1113 2.054207
32R:R:L1153 5.60254159
33R:R:L1154 5.5854166
34R:R:L1156 2.575166
35R:R:W1158 8.23333698
36R:R:F1160 5.178598
37R:R:Y1174 4.445179
38R:R:F1176 6.32333699
39R:R:M1185 2.955407
40R:R:F1188 6.021676187
41R:R:F1190 5.1075408
42R:R:Y1202 4.86507
43G:G:L19 2.555219
44G:G:V30 2.3125408
45G:G:D48 6.368509
46G:G:L51 4.655406
47G:G:N59 5.462529
48G:G:F61 3.88429728
49A:A:H41 4.2075456
50A:A:L45 3.864268
51A:A:V214 3.52456
52A:A:F219 5.405458
53A:A:R228 5.3625419
54A:A:F238 5.252519
55A:A:Y253 7.6625408
56A:A:R265 6.5154279
57A:A:W277 5.876676136
58A:A:F290 4.06254119
59A:A:L291 2.875488
60A:A:K293 5.2625409
61A:A:Y311 5.52406
62A:A:F312 3.164288
63A:A:P321 3.4625405
64A:A:E330 5.446583
65A:A:F340 8.99254287
66A:A:R342 5.096584
67A:A:E344 6.4854285
68A:A:F345 5.335408
69A:A:D354 4.745403
70A:A:Y360 6.235408
71A:A:F363 6.005485
72A:A:T364 4.97754119
73A:A:N371 5.294119
74A:A:R374 4.655404
75A:A:D378 8.164117
76B:B:I37 3.555602
77B:B:V40 4.3454233
78B:B:M45 3.3545224
79B:B:L51 6.19429
80B:B:R52 6.6975407
81B:B:H54 6.09667629
82B:B:K57 7.5625419
83B:B:W63 4.86571727
84B:B:S72 3.9225429
85B:B:Q75 5.45419
86B:B:D76 6.824249
87B:B:W82 6.36629
88B:B:D83 5.1875428
89B:B:Y85 10.565424
90B:B:K89 5.316529
91B:B:H91 5.3854145
92B:B:I93 3.624147
93B:B:W99 6.26429719
94B:B:Y105 4.0675406
95B:B:Y111 4.86404
96B:B:L117 3.3375419
97B:B:D118 2.905409
98B:B:Y124 3.377147146
99B:B:V133 3.5654144
100B:B:L139 5.4225409
101B:B:H142 5.68857719
102B:B:Y145 3.47143718
103B:B:F151 3.915409
104B:B:T159 5.745419
105B:B:D163 7.395419
106B:B:L168 3.565466
107B:B:W169 6.79571718
108B:B:F180 5.11667667
109B:B:H183 6.618569
110B:B:D186 5.75419
111B:B:V187 4.72469
112B:B:L190 4.8025405
113B:B:F199 4.212569
114B:B:S201 3.874569
115B:B:C204 4.2975417
116B:B:K209 7.8625466
117B:B:W211 5.906568
118B:B:D212 3.535409
119B:B:Q220 4.7225437
120B:B:F222 5.664538
121B:B:H225 8.532539
122B:B:D228 7.415419
123B:B:I232 4.7075438
124B:B:F235 5.89333606
125B:B:F241 5.17333636
126B:B:T243 4.455438
127B:B:S245 6.8975439
128B:B:D247 5.1425439
129B:B:R251 9.1375408
130B:B:F253 7.31436
131B:B:L255 2.88436
132B:B:R256 4.555409
133B:B:D258 7.9175437
134B:B:M262 5.75254104
135B:B:Y264 3.544297105
136B:B:C271 3.0525415
137B:B:I273 4.665406
138B:B:F278 5.665407
139B:B:R283 7.36254239
140B:B:L284 4.3475405
141B:B:Y289 5.85107
142B:B:V296 3.44405
143B:B:W297 5.34108
144B:B:L308 4.41754227
145B:B:H311 8.7154309
146B:B:R314 10.31518
147B:B:T321 5.58427
148B:B:T329 3.52408
149B:B:W332 11.036519
150B:B:L336 4.07427
151B:B:K337 3.79406
152B:B:W339 4.4845229
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F925 R:R:L928 28.51083.65YesYes099
2R:R:F925 R:R:S1181 10.60023.96YesNo097
3R:R:L928 R:R:W1081 10.20015.69YesNo096
4R:R:I1093 R:R:M929 10.19275.83YesYes089
5R:R:G952 R:R:S1181 10.19253.71NoNo097
6R:R:E992 R:R:I953 10.20015.47NoYes499
7R:R:L984 R:R:W1025 67.68152.28NoYes099
8R:R:L984 R:R:M1026 67.48484.24NoYes098
9R:R:F1023 R:R:M1026 33.64712.49NoYes098
10R:R:F1023 R:R:W1158 33.247615.03NoYes098
11R:R:M1026 R:R:Q1183 33.44424.08YesNo089
12R:R:Q1183 R:R:W1158 33.24465.48NoYes098
13G:G:D48 G:G:L51 39.84768.14YesYes096
14G:G:D48 G:G:P49 49.70754.83YesNo097
15B:B:M325 G:G:P49 49.86393.35NoNo057
16B:B:D323 B:B:M325 50.02035.54NoNo075
17B:B:D323 B:B:T321 50.16565.78NoYes277
18B:B:T321 B:B:W63 50.80179.7YesYes277
19B:B:L70 B:B:W63 51.07149.11NoYes257
20B:B:L70 B:B:W82 66.70732.28NoYes259
21B:B:S72 B:B:W82 41.68292.47YesYes299
22B:B:H54 B:B:S72 49.7965.58YesYes299
23B:B:H54 B:B:S74 49.94829.76YesNo099
24B:B:D76 B:B:S74 49.98187.36YesNo099
25A:A:Y37 B:B:D76 99.80973.45NoYes2449
26A:A:R42 A:A:Y37 1007.2NoNo094
27A:A:F222 A:A:R42 99.99383.21NoNo079
28A:A:F222 B:B:W99 99.943214.03NoYes079
29A:A:F238 B:B:W99 94.26815.01YesYes199
30A:A:F238 A:A:V241 94.93422.62YesNo099
31A:A:I285 A:A:V241 94.92261.54NoNo079
32A:A:I244 A:A:I285 94.9974.42NoNo087
33A:A:I244 A:A:V287 94.98541.54NoNo086
34A:A:V287 A:A:W277 94.97373.68NoYes066
35A:A:C359 A:A:W277 94.83272.61NoYes1356
36A:A:C359 A:A:F273 94.85772.79NoNo059
37A:A:F273 A:A:F345 94.80574.29NoYes098
38A:A:F345 A:A:L270 97.89619.74YesNo086
39A:A:E344 A:A:L270 97.88272.65YesNo056
40A:A:E344 A:A:F340 97.659610.49YesYes2857
41A:A:F315 A:A:F340 97.669812.86NoYes067
42A:A:F315 A:A:I308 97.73423.77NoNo067
43A:A:I308 A:A:Y253 97.72027.25NoYes078
44A:A:Y253 A:A:Y311 97.64957.94YesYes086
45A:A:N264 A:A:Y311 97.57799.3NoYes096
46A:A:D252 A:A:N264 97.56355.39NoNo089
47A:A:D252 A:A:R265 97.54910.72NoYes089
48A:A:N50 A:A:R265 97.47044.82NoYes2799
49A:A:D249 A:A:N50 97.49084.04NoNo089
50A:A:D249 A:A:K293 97.47628.3NoYes089
51A:A:K293 A:A:N292 97.40256.99YesNo099
52A:A:N292 A:A:T364 97.37274.39NoYes099
53A:A:F290 A:A:T364 48.85533.89YesYes1199
54A:A:F290 A:A:I245 48.46532.51YesNo097
55A:A:I245 A:A:L45 48.39942.85NoYes078
56A:A:L45 A:A:M221 48.16882.83YesNo088
57A:A:F212 A:A:M221 96.11592.49NoNo098
58A:A:F212 A:A:F219 96.032710.72NoYes098
59A:A:F219 A:A:H41 48.08364.53YesYes586
60A:A:H41 R:R:F1041 47.71596.79YesYes569
61A:A:I383 R:R:F1041 92.89412.51NoYes589
62A:A:H387 A:A:I383 92.50025.3NoNo588
63A:A:H387 R:R:M1036 92.331811.82NoNo088
64R:R:M1036 R:R:Q1032 79.87582.72NoYes088
65R:R:F1051 R:R:Q1032 69.89852.34NoYes058
66R:R:F1051 R:R:L1028 68.69413.65NoNo057
67R:R:L1028 R:R:W1025 68.49795.69NoYes079
68B:B:L284 B:B:V296 11.12945.96YesYes055
69B:B:I80 B:B:W82 41.68648.22NoYes089
70B:B:H54 B:B:I80 41.90447.95YesNo098
71B:B:H54 B:B:K78 49.99342.62YesNo098
72B:B:D76 B:B:K78 50.06069.68YesNo098
73A:A:N371 A:A:T364 48.30735.85YesYes1199
74A:A:I56 A:A:N371 48.23085.66NoYes079
75A:A:I56 A:A:M60 48.06515.83NoNo079
76A:A:M221 A:A:M60 48.0322.89NoNo089
77A:A:F219 A:A:V217 47.78243.93YesNo585
78A:A:V217 R:R:F1041 47.69055.24NoYes559
79B:B:D258 B:B:F222 10.55044.78YesYes378
80B:B:H225 B:B:T243 16.12915.48YesYes398
81B:B:H225 B:B:S245 16.777416.74YesYes399
82B:B:G244 B:B:S245 17.76231.86NoYes059
83B:B:G244 B:B:I273 17.92493.53NoYes056
84B:B:C250 B:B:I273 18.54654.91NoYes086
85B:B:C250 B:B:Y264 18.70862.69NoYes085
86B:B:M262 B:B:Y264 25.03249.58YesYes1045
87B:B:L30 B:B:M262 25.83927.07NoYes054
88B:B:L30 B:B:T34 27.60492.95NoNo055
89B:B:I37 B:B:T34 27.76534.56YesNo025
90B:B:I37 B:B:R283 29.04313.76YesYes029
91B:B:R283 G:G:L51 30.3324.86YesYes096
92B:B:C148 B:B:L190 19.9514.76NoYes065
93B:B:C148 B:B:R150 20.43695.57NoNo066
94B:B:H62 B:B:R150 22.382211.28NoNo066
95B:B:H62 B:B:Y105 23.35363.27NoYes066
96B:B:L69 B:B:Y105 36.93862.34NoYes056
97B:B:D83 B:B:L69 37.42332.71YesNo085
98B:B:D83 B:B:Y85 39.35872.3YesYes284
99B:B:Y85 G:G:F61 40.79856.19YesYes248
100B:B:S84 G:G:F61 15.89163.96NoYes258
101B:B:L70 B:B:S84 15.48533NoNo255
102B:B:I338 G:G:F61 30.6592.51NoYes058
103B:B:I338 B:B:L51 30.96172.85NoYes059
104B:B:L51 B:B:W82 15.974714.81YesYes299
105B:B:L336 B:B:L51 15.94664.15YesYes279
106B:B:L79 B:B:V71 10.71394.47NoNo078
107B:B:V71 B:B:Y105 12.66016.31NoYes086
108B:B:I93 B:B:L79 10.22732.85YesNo077
109R:R:L928 R:R:W1158 39.81322.28YesYes098
110R:R:M929 R:R:W1158 19.11584.65YesYes998
111R:R:F925 R:R:I953 13.4455.02YesYes499
112R:R:H981 R:R:R977 11.69065.64YesYes1599
113A:A:Y391 R:R:M1036 12.28027.18NoNo048
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WY8
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRL3
Species Mus musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.83
Date 2022-10-26 
D.O.I. 10.1016/j.molcel.2022.10.009
Net Summary
Imin 2.28
Number of Linked Nodes 834
Number of Links 966
Number of Hubs 152
Number of Links mediated by Hubs 559
Number of Communities 30
Number of Nodes involved in Communities 205
Number of Links involved in Communities 270
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 6357875
Length Of Smallest Path 3
Average Path Length 61.094
Length of Longest Path 96
Minimum Path Strength 1.31
Average Path Strength 5.55134
Maximum Path Strength 20.035
Minimum Path Correlation 0.71
Average Path Correlation 0.994384
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.38889
Average % Of Corr. Nodes 24.871
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.0526
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ80TS3
Sequence
>7WY8_Chain_R
TNFAVLMAH VEVKHSDAV HDLLLDVIT WVGILLSLV CLLICIFTF 
CFFRGLQSD RNTIHKNLC ISLFVAELL FLIGINRTD QPIACAVFA 
ALLHFFFLA AFTWMFLEG VQLYIMLVE VFESEHSRR KYFYLVGYG 
MPALIVAVS AAVDYRSYG TDKVCWLRL DTYFIWSFI GPATLIIML 
NVIFLGIAL YKMFHHTWV IGAIALLCL LGLTWAFGL MYINESTVI 
MAYLFTIFN SLQGMFIFI FHCVLQKKV RKEYGKCLR T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WY8_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7WY8_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIYHT SGIFETKFQ VDKVNFHMF DVGAQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCSV DTENARRIF NDCRDIIQR 
MHLRQYE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WY8_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SF7B2AdhesionAdhesionADGRL3Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;22.92022-04-2710.1038/s41586-022-04575-7
7WY5B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WY8B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WYBB2AdhesionAdhesionADGRL3Mus musculus--Gi1/&β;1/&γ;22.972022-10-2610.1016/j.molcel.2022.10.009
7X10B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-G12)/&β;1/&γ;22.932022-10-2610.1016/j.molcel.2022.10.009
8JMTB2AdhesionAdhesionADGRL3Homo sapiens---3.32023-09-0610.1038/s41589-023-01389-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WY8.zip



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