psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N843	R:R:T842	4.39	Yes	No	4	8	9
2	R:R:D865	R:R:T842	5.78	No	No	4	5	9
3	R:R:L864	R:R:N843	8.24	No	Yes	0	7	8
4	R:R:D865	R:R:N843	5.39	No	Yes	4	5	8
5	R:R:F844	R:R:L847	3.65	Yes	No	0	9	9
6	R:R:F844	R:R:T868	5.19	Yes	No	2	9	8
7	R:R:F844	R:R:I872	3.77	Yes	Yes	2	9	9
8	R:R:F1086	R:R:F844	5.36	Yes	Yes	2	9	9
9	R:R:F914	R:R:V846	2.62	No	No	0	8	7
10	R:R:V846	R:R:V998	4.81	No	No	0	7	6
11	R:R:F914	R:R:L847	6.09	No	No	0	8	9
12	R:R:L847	R:R:W1000	9.11	No	Yes	0	9	8
13	R:R:L1072	R:R:M848	2.83	No	No	0	9	9
14	R:R:H850	R:R:V851	5.54	No	No	0	6	4
15	R:R:E852	R:R:K997	5.4	No	No	0	5	4
16	R:R:V853	R:R:Y1074	12.62	No	No	0	4	7
17	R:R:H855	R:R:Y1074	3.27	No	No	0	1	7
18	R:R:H855	R:R:V1080	4.15	No	No	0	1	4
19	R:R:D857	R:R:V859	4.38	No	No	0	1	3
20	R:R:H860	R:R:Y1084	7.62	No	Yes	0	5	8
21	R:R:L863	R:R:Y1084	5.86	No	Yes	0	5	8
22	R:R:L864	R:R:Y1084	4.69	No	Yes	0	7	8
23	R:R:L864	R:R:T1087	4.42	No	No	0	7	8
24	R:R:D865	R:R:W869	3.35	No	No	0	5	5
25	R:R:I1088	R:R:I867	4.42	No	No	0	7	8
26	R:R:I872	R:R:T868	3.04	Yes	No	2	9	8
27	R:R:T1087	R:R:T868	3.14	No	No	0	8	8
28	R:R:L873	R:R:W869	5.69	No	No	0	6	5
29	R:R:L915	R:R:W869	5.69	No	No	0	9	5
30	R:R:G871	R:R:S1091	3.71	No	No	0	9	7
31	R:R:G871	R:R:L1092	3.42	No	No	0	9	4
32	R:R:I872	R:R:L876	2.85	Yes	No	0	9	9
33	R:R:I872	R:R:L915	4.28	Yes	No	0	9	9
34	R:R:E911	R:R:S875	2.87	No	No	0	9	9
35	R:R:G1094	R:R:S875	3.71	No	No	0	8	9
36	R:R:F908	R:R:L876	3.65	No	No	0	8	9
37	R:R:E911	R:R:L876	6.63	No	No	0	9	9
38	R:R:C878	R:R:F1098	5.59	No	Yes	0	8	6
39	R:R:C904	R:R:L879	3.17	No	No	0	8	9
40	R:R:F1098	R:R:I881	7.54	Yes	No	0	6	5
41	R:R:C882	R:R:F886	4.19	No	No	0	6	9
42	R:R:C882	R:R:C904	3.64	No	No	0	6	8
43	R:R:C904	R:R:I883	3.27	No	No	0	8	7
44	R:R:I883	R:R:I905	2.94	No	No	0	7	6
45	R:R:F886	R:R:T885	3.89	No	Yes	0	9	9
46	R:R:F889	R:R:T885	5.19	Yes	Yes	3	8	9
47	R:R:C1102	R:R:T885	5.07	No	Yes	3	9	9
48	R:R:T885	R:R:Y1112	8.74	Yes	Yes	3	9	5
49	R:R:F886	R:R:N897	4.83	No	No	0	9	8
50	R:R:C887	R:R:K901	3.23	No	No	0	9	9
51	R:R:F888	R:R:F889	5.36	No	Yes	0	8	8
52	R:R:F889	R:R:Y1112	5.16	Yes	Yes	3	8	5
53	R:R:K1107	R:R:L892	5.64	No	No	0	9	8
54	R:R:E1111	R:R:L892	7.95	No	No	0	7	8
55	R:R:N897	R:R:S894	4.47	No	No	0	8	8
56	R:R:D895	R:R:R967	8.34	No	No	0	9	5
57	R:R:H900	R:R:R896	5.64	No	No	0	9	9
58	R:R:Q951	R:R:R896	3.5	Yes	No	0	8	9
59	R:R:R967	R:R:T898	5.17	No	No	0	5	9
60	R:R:I899	R:R:W944	5.87	Yes	Yes	1	9	9
61	R:R:I899	R:R:L947	2.85	Yes	No	1	9	8
62	R:R:E948	R:R:I899	6.83	No	Yes	1	9	9
63	R:R:I899	R:R:Q951	2.74	Yes	Yes	0	9	8
64	R:R:E948	R:R:H900	11.08	No	No	1	9	9
65	R:R:H900	R:R:L1063	3.86	No	Yes	1	9	9
66	R:R:N902	R:R:W944	20.34	No	Yes	1	9	9
67	R:R:N902	R:R:Y971	5.81	No	No	0	9	9
68	R:R:N902	R:R:Y975	3.49	No	No	1	9	9
69	R:R:L903	R:R:L907	2.77	No	No	0	9	9
70	R:R:L903	R:R:M945	2.83	No	No	0	9	8
71	R:R:A940	R:R:S906	3.42	No	No	0	7	7
72	R:R:A941	R:R:S906	3.42	No	No	0	7	7
73	R:R:A941	R:R:L907	3.15	No	No	0	7	9
74	R:R:F937	R:R:V909	11.8	No	No	0	7	6
75	R:R:A910	R:R:F938	8.32	No	No	0	8	8
76	R:R:I916	R:R:L912	7.14	No	No	0	5	7
77	R:R:L913	R:R:L934	2.77	No	No	0	5	8
78	R:R:G917	R:R:I916	3.53	No	No	0	8	5
79	R:R:F930	R:R:G917	7.53	Yes	No	0	5	8
80	R:R:I918	R:R:N919	4.25	No	No	0	8	6
81	R:R:I918	R:R:V998	3.07	No	No	0	8	6
82	R:R:C999	R:R:T921	5.07	No	No	0	9	7
83	R:R:P924	R:R:Q923	6.32	No	No	0	4	5
84	R:R:A926	R:R:Q923	3.03	No	No	0	4	5
85	R:R:C927	R:R:C999	7.28	No	No	0	9	9
86	R:R:A931	R:R:Y993	5.34	No	Yes	0	9	9
87	R:R:A932	R:R:Y993	2.67	No	Yes	0	7	9
88	R:R:H935	R:R:L939	6.43	Yes	No	0	9	9
89	R:R:H935	R:R:Y993	5.44	Yes	Yes	0	9	9
90	R:R:H935	R:R:S1010	2.79	Yes	No	0	9	8
91	R:R:F1011	R:R:H935	3.39	Yes	Yes	0	9	9
92	R:R:F936	R:R:F937	9.65	Yes	No	0	7	7
93	R:R:F936	R:R:P978	4.33	Yes	No	0	7	9
94	R:R:F936	R:R:V982	2.62	Yes	No	0	7	9
95	R:R:I981	R:R:L939	4.28	No	No	0	8	9
96	R:R:A940	R:R:Y975	2.67	No	No	0	7	9
97	R:R:F1011	R:R:F942	5.36	Yes	Yes	0	9	9
98	R:R:A1015	R:R:F942	4.16	No	Yes	0	7	9
99	R:R:F942	R:R:W1068	9.02	Yes	Yes	0	9	9
100	R:R:G974	R:R:T943	3.64	No	No	0	9	5
101	R:R:L947	R:R:W944	4.56	No	Yes	1	8	9
102	R:R:G974	R:R:W944	4.22	No	Yes	0	9	9
103	R:R:W944	R:R:Y975	10.61	Yes	No	1	9	9
104	R:R:M945	R:R:Q1093	4.08	No	No	0	8	9
105	R:R:F946	R:R:V950	3.93	No	No	0	9	8
106	R:R:F946	R:R:I1018	3.77	No	No	0	9	5
107	R:R:F946	R:R:L1021	7.31	No	No	0	9	5
108	R:R:L947	R:R:V973	2.98	No	No	0	8	4
109	R:R:E948	R:R:L1063	11.93	No	Yes	1	9	9
110	R:R:F1025	R:R:G949	4.52	No	No	0	6	6
111	R:R:I954	R:R:Q951	4.12	No	Yes	0	8	8
112	R:R:V957	R:R:Y953	10.09	No	No	0	8	8
113	R:R:I954	R:R:R966	3.76	No	Yes	0	8	9
114	R:R:E958	R:R:R966	5.82	No	Yes	0	8	9
115	R:R:R966	R:R:S962	9.22	Yes	No	0	9	9
116	R:R:E963	R:R:H964	19.69	No	No	0	7	4
117	R:R:K968	R:R:Y969	3.58	No	No	0	8	9
118	R:R:S985	R:R:V982	3.23	No	No	0	8	9
119	R:R:S985	R:R:Y993	3.82	No	Yes	0	8	9
120	R:R:F1007	R:R:S985	2.64	Yes	No	0	8	8
121	R:R:D989	R:R:S992	8.83	No	Yes	0	9	8
122	R:R:R991	R:R:Y990	14.4	No	No	0	4	6
123	R:R:R1002	R:R:S992	2.64	No	Yes	6	7	8
124	R:R:S992	R:R:T1005	4.8	Yes	No	6	8	7
125	R:R:T995	R:R:V998	3.17	No	No	0	9	6
126	R:R:L1001	R:R:W1000	12.53	No	Yes	5	8	8
127	R:R:I1008	R:R:W1000	3.52	Yes	Yes	5	7	8
128	R:R:F1011	R:R:W1000	5.01	Yes	Yes	0	9	8
129	R:R:F1007	R:R:L1001	3.65	Yes	No	0	8	8
130	R:R:I1008	R:R:L1001	4.28	Yes	No	5	7	8
131	R:R:D1004	R:R:R1002	8.34	No	No	0	8	7
132	R:R:R1002	R:R:T1005	7.76	No	No	6	7	7
133	R:R:I1008	R:R:L1003	4.28	Yes	No	0	7	5
134	R:R:F1007	R:R:S1010	2.64	Yes	No	0	8	8
135	R:R:I1012	R:R:W1009	5.87	No	No	0	9	7
136	R:R:G1013	R:R:P1014	4.06	No	No	0	9	9
137	R:R:M1020	R:R:T1016	6.02	No	No	0	5	7
138	R:R:I1018	R:R:N1022	2.83	No	No	0	5	8
139	R:R:L1064	R:R:N1022	5.49	No	No	0	6	8
140	R:R:L1026	R:R:L1030	2.77	No	No	0	9	5
141	R:R:L1026	R:R:L1060	2.77	No	No	0	9	9
142	R:R:L1026	R:R:L1064	4.15	No	No	0	9	6
143	R:R:I1028	R:R:K1032	2.91	No	No	0	6	8
144	R:R:L1030	R:R:W1053	5.69	No	Yes	0	5	7
145	R:R:K1032	R:R:Y1031	5.97	No	No	0	8	5
146	R:R:H1035	R:R:Y1031	6.53	No	No	0	6	5
147	R:R:H1036	R:R:K1032	5.24	No	No	0	5	8
148	R:R:M1033	R:R:W1053	10.47	No	Yes	0	9	7
149	R:R:A1038	R:R:F1034	2.77	No	No	7	5	4
150	R:R:F1034	R:R:N1049	7.25	No	Yes	7	4	6
151	R:R:H1035	R:R:H1036	5.97	No	No	0	6	5
152	R:R:H1035	R:R:I1039	3.98	No	No	0	6	5
153	R:R:A1038	R:R:N1049	4.69	No	Yes	7	5	6
154	R:R:K1041	R:R:L1040	11.28	No	No	0	8	6
155	R:R:D1048	R:R:K1051	4.15	No	No	0	5	3
156	R:R:N1049	R:R:S1052	2.98	Yes	No	0	6	8
157	R:R:N1049	R:R:W1053	5.65	Yes	Yes	0	6	7
158	R:R:I1050	R:R:W1053	7.05	No	Yes	0	6	7
159	R:R:G1056	R:R:I1055	3.53	No	No	0	7	5
160	R:R:A1059	R:R:F1100	6.93	No	No	1	5	7
161	R:R:A1059	R:R:H1101	2.93	No	No	1	5	8
162	R:R:L1061	R:R:L1066	4.15	No	Yes	0	8	8
163	R:R:C1062	R:R:F1096	2.79	No	No	0	5	8
164	R:R:C1062	R:R:I1097	3.27	No	No	0	5	8
165	R:R:I1097	R:R:L1063	2.85	No	Yes	0	8	9
166	R:R:H1101	R:R:L1063	10.29	No	Yes	1	8	9
167	R:R:L1064	R:R:L1066	2.77	No	Yes	0	6	8
168	R:R:F1089	R:R:T1067	3.89	No	No	0	7	9
169	R:R:N1090	R:R:T1067	7.31	No	No	0	9	9
170	R:R:F1086	R:R:W1068	4.01	Yes	Yes	2	9	9
171	R:R:N1090	R:R:W1068	19.21	No	Yes	2	9	9
172	R:R:Q1093	R:R:W1068	5.48	No	Yes	0	9	9
173	R:R:F1070	R:R:M1082	4.98	No	No	0	8	7
174	R:R:F1086	R:R:G1071	4.52	Yes	No	0	9	9
175	R:R:M1073	R:R:T1079	3.01	No	No	0	5	8
176	R:R:M1073	R:R:M1082	15.88	No	No	0	5	7
177	R:R:A1083	R:R:Y1074	8.01	No	No	0	9	7
178	R:R:N1076	R:R:S1078	4.47	No	No	0	5	5
179	R:R:N1076	R:R:T1079	2.92	No	No	0	5	8
180	R:R:V1080	R:R:Y1084	3.79	No	Yes	0	4	8
181	R:R:F1089	R:R:L1085	6.09	No	No	0	7	9
182	R:R:F1086	R:R:N1090	16.92	Yes	No	2	9	9
183	R:R:F1089	R:R:I1088	3.77	No	No	0	7	7
184	R:R:F1096	R:R:M1095	3.73	No	No	0	8	6
185	R:R:F1096	R:R:I1099	3.77	No	No	0	8	6
186	R:R:F1098	R:R:I1099	3.77	Yes	No	0	6	6
187	R:R:C1102	R:R:F1098	5.59	No	Yes	0	9	6
188	R:R:F1098	R:R:V1103	5.24	Yes	No	0	6	5
189	R:R:F1100	R:R:H1101	3.39	No	No	1	7	8
190	R:R:C1102	R:R:Y1112	4.03	No	Yes	3	9	5
191	R:R:K1107	R:R:Q1105	2.71	No	No	0	9	8
192	R:R:K1106	R:R:K1110	2.87	No	No	0	8	6
193	R:R:V1108	R:R:Y1112	5.05	No	Yes	0	9	5
194	R:R:G1113	R:R:L1116	3.42	No	No	0	6	4
195	R:R:A1057	R:R:W1053	2.59	No	Yes	0	8	7
196	R:R:F1070	R:R:T1067	2.59	No	No	0	8	9
197	R:R:F942	R:R:I1018	2.51	Yes	No	0	9	5
198	R:R:F1086	R:R:M848	2.49	Yes	No	0	9	9
199	R:R:F930	R:R:L913	2.44	Yes	No	0	5	5
200	R:R:F938	R:R:L934	2.44	No	No	0	8	8
201	R:R:F1100	R:R:L1104	2.44	No	No	0	7	8
202	R:R:F1025	R:R:N1022	2.42	No	No	0	6	8
203	R:R:F970	R:R:Q951	2.34	No	Yes	0	5	8
204	R:R:E1111	R:R:F889	2.33	No	Yes	0	7	8
205	R:R:F1011	R:R:F938	2.14	Yes	No	0	9	8
206	R:R:F1025	R:R:Y953	2.06	No	No	0	6	8
207	R:R:G976	R:R:P978	2.03	No	No	0	5	9
208	R:R:A1059	R:R:G1056	1.95	No	No	0	5	7
209	R:R:G871	R:R:V870	1.84	No	No	0	9	8
210	R:R:G994	R:R:T995	1.82	No	No	0	9	9
211	R:R:G1013	R:R:T1016	1.82	No	No	0	9	7
212	R:R:G1065	R:R:M945	1.75	No	No	0	6	8
213	R:R:G949	R:R:L952	1.71	No	No	0	6	9
214	R:R:G1027	R:R:L1030	1.71	No	No	0	5	5
215	R:R:M977	R:R:P978	1.68	No	No	0	4	9
216	R:R:L939	R:R:P1014	1.64	No	No	0	9	9
217	R:R:A1029	R:R:M1033	1.61	No	No	0	8	9
218	R:R:V866	R:R:V870	1.6	No	No	0	6	8
219	R:R:V984	R:R:V988	1.6	No	No	0	7	6
220	R:R:A1029	R:R:L956	1.58	No	No	0	8	8
221	R:R:A858	R:R:D861	1.54	No	No	0	1	4
222	R:R:I899	R:R:T898	1.52	Yes	No	0	9	9
223	R:R:L1092	R:R:S875	1.5	No	No	0	4	9
224	R:R:G917	R:R:R920	1.5	No	No	0	8	7
225	R:R:L1066	R:R:V1023	1.49	Yes	No	0	8	5
226	R:R:I1008	R:R:I1012	1.47	Yes	No	0	7	9
227	R:R:I905	R:R:K901	1.45	No	No	0	6	9
228	R:R:I1050	R:R:K1051	1.45	No	No	0	6	3
229	R:R:G1113	R:R:Y1112	1.45	No	Yes	0	6	5
230	R:R:I1019	R:R:L1066	1.43	No	Yes	0	8	8
231	R:R:I1024	R:R:L1021	1.43	No	No	0	5	5
232	R:R:I1058	R:R:L1061	1.43	No	No	0	6	8
233	R:R:L1017	R:R:M1020	1.41	No	No	0	4	5
234	R:R:A926	R:R:F930	1.39	No	Yes	0	4	5
235	R:R:A979	R:R:F936	1.39	No	Yes	0	7	7
236	R:R:L1092	R:R:L874	1.38	No	No	0	4	6
237	R:R:L913	R:R:L933	1.38	No	No	0	5	5
238	R:R:D996	R:R:K997	1.38	No	No	0	2	4
239	R:R:I925	R:R:Q923	1.37	No	No	0	5	5
240	R:R:H1036	R:R:T1037	1.37	No	No	0	5	5
241	R:R:D861	R:R:N843	1.35	No	Yes	0	4	8
242	R:R:E852	R:R:K854	1.35	No	No	0	5	3
243	R:R:H850	R:R:I1075	1.33	No	No	0	6	6
244	R:R:F1007	R:R:S992	1.32	Yes	Yes	0	8	8
245	R:R:F930	R:R:V929	1.31	Yes	No	0	5	7
246	R:R:E1077	R:R:N1076	1.31	No	No	0	6	5
247	R:R:H850	R:R:L1003	1.29	No	No	0	6	5
248	R:R:M955	R:R:R896	1.24	No	No	0	8	9
249	R:R:K1106	R:R:R1109	1.24	No	No	0	8	7
250	R:R:F908	R:R:L880	1.22	No	No	0	8	5
251	R:R:D989	R:R:R991	1.19	No	No	0	9	4
252	R:R:Q893	R:R:R890	1.17	No	No	0	9	8
253	R:R:R966	R:R:Y969	1.03	Yes	No	0	9	9
254	R:R:W1009	R:R:Y1006	0.96	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N843	4.8425	4	4	8
2	R:R:F844	4.4925	4	2	9
3	R:R:I872	3.485	4	2	9
4	R:R:T885	5.7225	4	3	9
5	R:R:F889	4.51	4	3	8
6	R:R:I899	3.962	5	1	9
7	R:R:F930	3.1675	4	0	5
8	R:R:H935	4.5125	4	0	9
9	R:R:F936	4.4975	4	0	7
10	R:R:F942	5.2625	4	0	9
11	R:R:W944	9.12	5	1	9
12	R:R:Q951	3.175	4	0	8
13	R:R:R966	4.9575	4	0	9
14	R:R:S992	4.3975	4	6	8
15	R:R:Y993	4.3175	4	0	9
16	R:R:W1000	7.5425	4	5	8
17	R:R:F1007	2.5625	4	0	8
18	R:R:I1008	3.3875	4	5	7
19	R:R:F1011	3.975	4	0	9
20	R:R:N1049	5.1425	4	7	6
21	R:R:W1053	6.29	5	0	7
22	R:R:L1063	7.2325	4	1	9
23	R:R:L1066	2.46	4	0	8
24	R:R:W1068	9.43	4	2	9
25	R:R:Y1084	5.49	4	0	8
26	R:R:F1086	6.66	5	2	9
27	R:R:F1098	5.546	5	0	6
28	R:R:Y1112	4.886	5	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F844	R:R:T868	24.4085	5.19	Yes	No	2	9	8
2	R:R:T1087	R:R:T868	24.4252	3.14	No	No	0	8	8
3	R:R:L864	R:R:T1087	22.7891	4.42	No	No	0	7	8
4	R:R:F844	R:R:L847	27.2948	3.65	Yes	No	0	9	9
5	R:R:F1086	R:R:F844	45.855	5.36	Yes	Yes	2	9	9
6	R:R:F914	R:R:L847	12.6951	6.09	No	No	0	8	9
7	R:R:F914	R:R:V846	11.0925	2.62	No	No	0	8	7
8	R:R:L847	R:R:W1000	24.6098	9.11	No	Yes	0	9	8
9	R:R:I1008	R:R:W1000	13.9872	3.52	Yes	Yes	5	7	8
10	R:R:L864	R:R:Y1084	14.6921	4.69	No	Yes	0	7	8
11	R:R:N1090	R:R:T1067	24.1567	7.31	No	No	0	9	9
12	R:R:L1092	R:R:S875	11.2183	1.5	No	No	0	4	9
13	R:R:E911	R:R:S875	14.8263	2.87	No	No	0	9	9
14	R:R:E911	R:R:L876	16.6051	6.63	No	No	0	9	9
15	R:R:I872	R:R:L876	21.8409	2.85	Yes	No	0	9	9
16	R:R:F1098	R:R:I1099	55.8483	3.77	Yes	No	0	6	6
17	R:R:F1096	R:R:I1099	57.3334	3.77	No	No	0	8	6
18	R:R:C1062	R:R:F1096	60.2534	2.79	No	No	0	5	8
19	R:R:C1062	R:R:I1097	61.6882	3.27	No	No	0	5	8
20	R:R:I1097	R:R:L1063	63.1062	2.85	No	Yes	0	8	9
21	R:R:E948	R:R:L1063	68.6273	11.93	No	Yes	1	9	9
22	R:R:E948	R:R:I899	71.3123	6.83	No	Yes	1	9	9
23	R:R:I899	R:R:W944	85.8365	5.87	Yes	Yes	1	9	9
24	R:R:W944	R:R:Y975	90.3256	10.61	Yes	No	1	9	9
25	R:R:A940	R:R:Y975	93.9587	2.67	No	No	0	7	9
26	R:R:A940	R:R:S906	94.7726	3.42	No	No	0	7	7
27	R:R:A941	R:R:S906	95.5697	3.42	No	No	0	7	7
28	R:R:A941	R:R:L907	96.3501	3.15	No	No	0	7	9
29	R:R:L903	R:R:L907	97.1136	2.77	No	No	0	9	9
30	R:R:L903	R:R:M945	97.8604	2.83	No	No	0	9	8
31	R:R:M945	R:R:Q1093	99.3036	4.08	No	No	0	8	9
32	R:R:Q1093	R:R:W1068	100	5.48	No	Yes	0	9	9
33	R:R:F1086	R:R:W1068	41.9953	4.01	Yes	Yes	2	9	9
34	R:R:C882	R:R:C904	11.5707	3.64	No	No	0	6	8
35	R:R:C882	R:R:F886	13.4419	4.19	No	No	0	6	9
36	R:R:F886	R:R:T885	18.9545	3.89	No	Yes	0	9	9
37	R:R:C1102	R:R:T885	30.4833	5.07	No	Yes	3	9	9
38	R:R:C1102	R:R:F1098	49.7399	5.59	No	Yes	0	9	6
39	R:R:F889	R:R:T885	11.1932	5.19	Yes	Yes	3	8	9
40	R:R:F889	R:R:Y1112	10.824	5.16	Yes	Yes	3	8	5
41	R:R:C1102	R:R:Y1112	17.6707	4.03	No	Yes	3	9	5
42	R:R:E1111	R:R:L892	11.2519	7.95	No	No	0	7	8
43	R:R:E1111	R:R:F889	14.8011	2.33	No	Yes	0	7	8
44	R:R:I899	R:R:Q951	17.5365	2.74	Yes	Yes	0	9	8
45	R:R:F936	R:R:V982	13.0894	2.62	Yes	No	0	7	9
46	R:R:S985	R:R:V982	14.8934	3.23	No	No	0	8	9
47	R:R:F1007	R:R:L1001	19.0468	3.65	Yes	No	0	8	8
48	R:R:L1001	R:R:W1000	19.1475	12.53	No	Yes	5	8	8
49	R:R:F1011	R:R:F938	27.3032	2.14	Yes	No	0	9	8
50	R:R:F1011	R:R:W1000	33.8647	5.01	Yes	Yes	0	9	8
51	R:R:F930	R:R:L913	18.7867	2.44	Yes	No	0	5	5
52	R:R:L913	R:R:L934	22.3444	2.77	No	No	0	5	8
53	R:R:F938	R:R:L934	23.9218	2.44	No	No	0	8	8
54	R:R:H935	R:R:Y993	16.5296	5.44	Yes	Yes	0	9	9
55	R:R:F1011	R:R:H935	39.7298	3.39	Yes	Yes	0	9	9
56	R:R:H935	R:R:L939	12.8293	6.43	Yes	No	0	9	9
57	R:R:F1007	R:R:S1010	10.6394	2.64	Yes	No	0	8	8
58	R:R:H935	R:R:S1010	11.705	2.79	Yes	No	0	9	8
59	R:R:F942	R:R:W1068	85.652	9.02	Yes	Yes	0	9	9
60	R:R:F942	R:R:I1018	54.7239	2.51	Yes	No	0	9	5
61	R:R:I1018	R:R:N1022	47.466	2.83	No	No	0	5	8
62	R:R:I954	R:R:Q951	13.3328	4.12	No	Yes	0	8	8
63	R:R:I954	R:R:R966	11.0757	3.76	No	Yes	0	8	9
64	R:R:F1007	R:R:S992	21.8996	1.32	Yes	Yes	0	8	8
65	R:R:L1064	R:R:N1022	38.2027	5.49	No	No	0	6	8
66	R:R:L1026	R:R:L1064	28.3353	4.15	No	No	0	9	6
67	R:R:L1026	R:R:L1030	24.9119	2.77	No	No	0	9	5
68	R:R:L1030	R:R:W1053	21.3626	5.69	No	Yes	0	5	7
69	R:R:H1101	R:R:L1063	11.8728	10.29	No	Yes	1	8	9
70	R:R:F1070	R:R:T1067	14.3816	2.59	No	No	0	8	9
71	R:R:F1070	R:R:M1082	12.3762	4.98	No	No	0	8	7
72	R:R:M1073	R:R:M1082	10.3541	15.88	No	No	0	5	7
73	R:R:F844	R:R:I872	29.1576	3.77	Yes	Yes	2	9	9
74	R:R:F1011	R:R:F942	68.8287	5.36	Yes	Yes	0	9	9
75	R:R:S985	R:R:Y993	12.1916	3.82	No	Yes	0	8	9
76	R:R:N1090	R:R:W1068	19.0804	19.21	No	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7SF7_nogp

PDB Summary
PDB	7SF7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	246
Number of Links	254
Number of Hubs	28
Number of Links mediated by Hubs	102
Number of Communities	7
Number of Nodes involved in Communities	33
Number of Links involved in Communities	38

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	26636
Length Of Smallest Path	3
Average Path Length	15.8619
Length of Longest Path	37
Minimum Path Strength	1.31
Average Path Strength	4.68546
Maximum Path Strength	14.115
Minimum Path Correlation	0.7
Average Path Correlation	0.939929
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	56.6781
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.349
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cell adhesion • cell-cell adhesion • cellular process • cell-cell adhesion via plasma-membrane adhesion molecules • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • developmental process • multicellular organismal process • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • multicellular organism development • cell differentiation • anatomical structure development • cell migration • cell motility • system development • cellular component organization • cellular component biogenesis • cell junction organization • cellular component assembly • cell junction assembly • synapse organization • cellular component organization or biogenesis • synapse assembly • cellular anatomical structure • membrane • cell-cell junction • anchoring junction • cell junction • cell periphery • plasma membrane • synapse • glutamatergic synapse • axon • cell projection • neuron projection • plasma membrane bounded cell projection • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • hydrolase activity • GDP binding • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • guanyl-nucleotide exchange factor activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • system process • circulatory system process • regulation of blood pressure • blood circulation • regulation of vascular associated smooth muscle cell migration • negative regulation of locomotion • vascular associated smooth muscle cell migration • regulation of cell motility • negative regulation of vascular associated smooth muscle cell migration • regulation of smooth muscle cell migration • negative regulation of biological process • smooth muscle cell migration • muscle cell migration • negative regulation of smooth muscle cell migration • regulation of locomotion • regulation of cell migration • negative regulation of cellular process • negative regulation of cell motility • locomotion • negative regulation of cell migration • regulation of fibroblast migration • fibroblast migration • ameboidal-type cell migration • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • regulation of postsynapse assembly • regulation of synapse structure or activity • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • focal adhesion • cell-substrate junction • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle • organelle • cytoplasm • vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • brush border membrane • cluster of actin-based cell projections • brush border • plasma membrane region • cell projection membrane • postsynapse • nucleus • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9HAR2
Sequence	>7SF7_nogp_Chain_R T N F A V L M A H V E V K H S D A V H D L L L D V I T W V G I L L S L V C L L I C I F T F C F F R G L Q S D R N T I H K N L C I S L F V A E L L F L I G I N R T D Q P I A C A V F A A L L H F F F L A A F T W M F L E G V Q L Y I M L V E V F E S E H S R R K Y F Y L V G Y G M P A L I V A V S A A V D Y R S Y G T D K V C W L R L D T Y F I W S F I G P A T L I I M L N V I F L G I A L Y K M F H H T A I L K P E S G C L D N I K S W V I G A I A L L C L L G L T W A F G L M Y I N E S T V I M A Y L F T I F N S L Q G M F I F I F H C V L Q K K V R K E Y G K C L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JMT	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	-	3.3	2023-09-06	10.1038/s41589-023-01389-0
	7X10	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-G12)/β1/γ2	2.93	2022-10-26	10.1016/j.molcel.2022.10.009
	7X10 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.93	2022-10-26	10.1016/j.molcel.2022.10.009
	7WY5	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.83	2022-10-26	10.1016/j.molcel.2022.10.009
	7WY5 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	10.1016/j.molcel.2022.10.009
	7WY8	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.83	2022-10-26	10.1016/j.molcel.2022.10.009
	7WY8 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	10.1016/j.molcel.2022.10.009
	7WYB	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	Gi1/β1/γ2	2.97	2022-10-26	10.1016/j.molcel.2022.10.009
	7WYB (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.97	2022-10-26	10.1016/j.molcel.2022.10.009
	7SF7	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	2.9	2022-04-27	10.1038/s41586-022-04575-7
	7SF7 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-		2.9	2022-04-27	10.1038/s41586-022-04575-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7SF7_nogp.zip

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