Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R52 3.7654193
2A:A:I60 3.955407
3A:A:L61 3.435408
4A:A:L62 4.7625449
5A:A:K70 5.6075449
6A:A:F73 5.206547
7A:A:I211 3.734579
8A:A:F216 2.82254219
9A:A:F223 5.92754207
10A:A:W238 10.4317679
11A:A:L249 3.152548
12A:A:F250 5.09589
13A:A:V252 3.55407
14A:A:F277 7.3125489
15A:A:V281 3.8975407
16A:A:F286 6.08409
17A:A:I292 3.095449
18A:A:L293 3.1275489
19A:A:F294 4.386549
20A:A:N296 6.5754139
21A:A:K297 10.0654139
22A:A:K311 6.014154
23A:A:F314 5.5185158
24A:A:D320 5.254153
25A:A:F335 5.21588
26A:A:H349 6.7275449
27A:A:F350 9.3575405
28A:A:F363 4.09754208
29B:B:R22 4.575406
30B:B:R52 6.0125407
31B:B:H54 7.154119
32B:B:L55 4.555406
33B:B:K57 12.60754149
34B:B:W63 5.22714737
35B:B:R68 10.8675435
36B:B:S72 3.92254119
37B:B:D76 5.335119
38B:B:W82 7.212509
39B:B:S84 3.965435
40B:B:Y85 11.305434
41B:B:N88 5.5925407
42B:B:K89 7.705409
43B:B:H91 3.9675405
44B:B:I93 3.31754237
45B:B:W99 5.2675479
46B:B:Y105 3.9375406
47B:B:Y111 4.604554
48B:B:L117 7.645479
49B:B:I123 3.0725456
50B:B:Y124 3.541676236
51B:B:T128 2.366503
52B:B:V133 3.91254234
53B:B:H142 5.922559
54B:B:Y145 3.64667678
55B:B:R150 4.5375466
56B:B:F151 3.634559
57B:B:N155 4.7325403
58B:B:T159 5.3775459
59B:B:S161 5.1725409
60B:B:W169 7.48333658
61B:B:F180 6.515467
62B:B:D186 3.712509
63B:B:L190 3.0625465
64B:B:F199 4.32669
65B:B:G202 1.88406
66B:B:K209 10.945466
67B:B:W211 7.68833668
68B:B:D212 4.43754249
69B:B:Q220 4.775417
70B:B:F222 5.022518
71B:B:H225 7.562519
72B:B:D228 6.4175409
73B:B:I232 5.55418
74B:B:F234 5.065405
75B:B:F235 6.994297126
76B:B:F241 5.33667616
77B:B:T243 3.805418
78B:B:D247 4.565419
79B:B:R251 8.8625408
80B:B:F253 5.25416
81B:B:L255 2.88416
82B:B:D258 5.1525417
83B:B:Y264 4.965605
84B:B:F278 4.29407
85B:B:R283 5.67109
86B:B:Y289 7.08333617
87B:B:N295 9.3425416
88B:B:V296 2.794505
89B:B:W297 4.938518
90B:B:K301 5.0375405
91B:B:V307 3.665413
92B:B:L308 3.71597
93B:B:H311 9.1454169
94B:B:V315 4.39254167
95B:B:W332 18.4275409
96B:B:D333 6.64254169
97B:B:W339 6.124599
98G:G:L19 3.175409
99G:G:Y40 5.2954126
100G:G:D48 4.57609
101G:G:P49 3.9425407
102G:G:L51 3.63754106
103G:G:N59 7.8925439
104G:G:F61 4.49375838
105R:R:F925 4.5685259
106R:R:L928 4.16254259
107R:R:H936 5.1885171
108R:R:H941 5.69405
109R:R:L960 3.7975409
110R:R:F967 6.775429
111R:R:L973 2.665428
112R:R:R977 4.9825429
113R:R:N978 4.7675409
114R:R:N983 9.2875429
115R:R:H1016 4.7625409
116R:R:F1017 4.935408
117R:R:L1020 4.48409
118R:R:W1025 6.75714729
119R:R:E1029 4.918529
120R:R:L1033 3.3125409
121R:R:V1040 5.6425409
122R:R:P1059 3.29833609
123R:R:S1073 6.93409
124R:R:Y1074 3.471676189
125R:R:W1081 6.565406
126R:R:L1082 4.98754188
127R:R:F1088 8.51754188
128R:R:W1090 2.765407
129R:R:M1114 4.21754228
130R:R:L1156 3.132506
131R:R:W1158 10.334268
132R:R:Y1164 5.044176
133R:R:E1167 3.25754175
134R:R:Y1174 2.796509
135R:R:F1176 6.81754269
136R:R:T1177 2.6625409
137R:R:N1180 10.6554269
138R:R:F1188 5.76407
139R:R:F1190 4.465288
140R:R:Y1202 10.074527
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:R68 98.95182.43NoYes355
2B:B:L69 B:B:Y105 99.01732.34NoYes056
3B:B:G109 B:B:Y105 99.98574.35NoYes056
4B:B:G109 B:B:S108 1001.86NoNo056
5B:B:N110 B:B:S108 50.0245.96NoNo046
6B:B:N110 B:B:Y111 50.00454.65NoYes044
7B:B:I123 B:B:Y111 50.05462.42YesYes564
8B:B:I123 B:B:I157 49.38444.42YesNo567
9B:B:I157 B:B:W169 98.56253.52NoYes578
10B:B:D154 B:B:S108 49.99038.83NoNo066
11B:B:D154 B:B:Y111 49.98065.75NoYes064
12B:B:F151 B:B:Y111 49.58112.06YesYes594
13B:B:F151 B:B:I157 49.30192.51YesNo597
14B:B:H142 B:B:W169 92.79913.17YesYes598
15B:B:H142 B:B:S161 92.729912.55YesYes099
16B:B:G162 B:B:S161 91.98811.86NoYes099
17B:B:D186 B:B:G162 91.86256.71YesNo099
18B:B:D186 B:B:Y145 89.83795.75YesYes098
19A:A:W238 B:B:Y145 45.59372.89YesYes798
20A:A:I211 A:A:W238 21.80112.35YesYes799
21A:A:E213 A:A:I211 43.33262.73NoYes799
22A:A:E213 A:A:K224 64.56214.05NoNo097
23A:A:K224 A:A:K59 63.74482.87NoNo078
24B:B:L117 B:B:Y145 43.67683.52YesYes798
25A:A:I211 B:B:L117 21.77254.28YesYes799
26B:B:L117 B:B:W99 21.77284.56YesYes799
27A:A:E213 B:B:W99 21.63829.81NoYes799
28A:A:F242 A:A:W238 22.07555.01NoYes099
29A:A:F242 A:A:L61 21.94113.65NoYes098
30A:A:I245 A:A:L61 21.40232.85NoYes098
31A:A:I245 A:A:K59 21.26762.91NoNo098
32A:A:K59 A:A:L57 84.4665.64NoNo086
33A:A:L57 A:A:P222 83.923.28NoNo064
34A:A:I221 A:A:P222 83.37393.39NoNo044
35A:A:I221 R:R:F1041 82.82797.54NoNo049
36A:A:F363 R:R:F1041 77.91163.22YesNo089
37A:A:F223 A:A:F363 76.27013.22YesYes2078
38A:A:F223 A:A:I60 74.08383.77YesYes077
39A:A:I60 A:A:M225 70.80582.92YesNo077
40A:A:F73 A:A:M225 70.25893.73YesNo077
41A:A:F73 A:A:L249 60.40062.44YesYes478
42A:A:F294 A:A:L249 54.92264.87YesYes498
43A:A:F294 A:A:T351 47.81935.19YesNo099
44A:A:N296 A:A:T351 47.2714.39YesNo099
45B:B:G319 B:B:W63 71.25442.81NoYes057
46B:B:G319 B:B:S277 71.22741.86NoNo055
47B:B:L318 B:B:S277 71.17493NoNo065
48B:B:L286 B:B:L318 71.14884.15NoNo076
49B:B:L286 B:B:V296 70.97284.47NoYes075
50B:B:L308 B:B:V296 63.82762.98YesYes075
51B:B:C294 B:B:L308 49.1183.17NoYes057
52B:B:C294 B:B:V315 35.28985.12NoYes057
53A:A:D253 A:A:N296 43.42984.04NoYes1389
54A:A:D253 A:A:S255 42.88765.89NoNo089
55A:A:S254 A:A:S255 42.34651.63NoNo079
56A:A:M298 A:A:S254 40.70023.07NoNo067
57A:A:F350 A:A:M298 40.15148.71YesNo056
58A:A:F350 A:A:L295 32.46458.53YesNo058
59A:A:F335 A:A:L295 24.21152.44YesNo888
60A:A:F335 A:A:M274 17.07127.46YesNo087
61A:A:C334 A:A:M274 14.31991.62NoNo067
62A:A:C334 A:A:Y330 13.76959.41NoNo067
63A:A:F314 A:A:Y330 13.219111.35YesNo087
64B:B:H311 B:B:V315 14.61925.54YesYes1697
65B:B:D333 B:B:H311 42.21238.82YesYes1699
66B:B:D312 B:B:D333 56.15162.66NoYes059
67B:B:D312 R:R:K1204 55.94556.91NoNo057
68R:R:E1201 R:R:K1204 55.53468.1NoNo087
69R:R:E1201 R:R:Y1202 55.12242.24NoYes087
70R:R:T966 R:R:Y1202 53.03519.99NoYes297
71R:R:F967 R:R:T966 51.56567.78YesNo299
72R:R:F967 R:R:H981 51.41435.66YesNo299
73R:R:E1029 R:R:H981 49.94319.85YesNo299
74B:B:C294 B:B:T329 13.82523.38NoNo058
75B:B:H311 B:B:T329 27.77825.48YesNo098
76B:B:L308 B:B:W339 14.57896.83YesYes979
77B:B:T329 B:B:W339 14.07886.06NoYes089
78B:B:S331 B:B:V315 14.60333.23NoYes1697
79B:B:D333 B:B:S331 14.553410.31YesNo1699
80B:B:L300 B:B:R283 20.22074.86NoYes069
81B:B:A299 B:B:L300 19.88671.58NoNo056
82B:B:A299 B:B:L285 19.74651.58NoNo056
83B:B:L285 B:B:Y264 26.36813.52NoYes065
84B:B:C250 B:B:Y264 23.54554.03NoYes085
85B:B:C250 B:B:G244 23.33323.92NoNo185
86B:B:G244 B:B:S245 29.99791.86NoNo159
87B:B:H225 B:B:S245 28.947112.55YesNo199
88B:B:H225 B:B:T243 27.64025.48YesYes198
89B:B:F241 B:B:T243 14.74252.59YesYes168
90B:B:D258 B:B:F222 16.86114.78YesYes178
91B:B:D258 B:B:R22 15.28657.15YesYes076
92B:B:I18 B:B:R22 12.65287.52NoYes076
93B:B:I18 G:G:L19 12.1261.43NoYes079
94B:B:L14 G:G:L19 10.54535.54NoYes089
95B:B:T321 B:B:W63 24.071910.92NoYes377
96B:B:D323 B:B:T321 23.98447.23NoNo377
97B:B:D323 B:B:M325 23.96178.32NoNo075
98B:B:M325 G:G:P49 23.92523.35NoYes057
99G:G:D48 G:G:P49 23.70564.83YesYes097
100B:B:S281 G:G:D48 15.19162.94NoYes099
101B:B:R68 B:B:Y85 98.490926.75YesYes354
102B:B:S84 B:B:Y85 96.3912.54YesYes354
103R:R:E1029 R:R:I980 40.40145.47YesNo299
104R:R:I980 R:R:W1025 39.97934.7NoYes299
105R:R:G1055 R:R:W1025 38.32952.81NoYes089
106R:R:G1055 R:R:T1024 37.91183.64NoNo085
107R:R:P1059 R:R:T1024 37.70293.5YesNo095
108R:R:L1020 R:R:P1059 34.96034.93YesYes099
109R:R:H1016 R:R:L1020 34.12292.57YesYes099
110R:R:H1016 R:R:L1082 33.50012.57YesYes098
111R:R:L1082 R:R:W1081 29.098911.39YesYes086
112R:R:L928 R:R:W1081 23.63075.69YesYes096
113R:R:F925 R:R:L928 22.14722.44YesYes2599
114R:R:F925 R:R:T949 13.24836.49YesNo098
115R:R:T1177 R:R:T949 13.03563.14YesNo098
116B:B:S84 B:B:W63 95.31774.94YesYes357
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7X10
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRL3
Species Mus musculus
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-G12)/Beta1/Gamma2
PDB Resolution 2.93
Date 2022-10-26 
D.O.I. 10.1016/j.molcel.2022.10.009
Net Summary
Imin 1.86
Number of Linked Nodes 803
Number of Links 931
Number of Hubs 140
Number of Links mediated by Hubs 515
Number of Communities 28
Number of Nodes involved in Communities 175
Number of Links involved in Communities 234
Path Summary
Number Of Nodes in MetaPath 117
Number Of Links MetaPath 116
Number of Shortest Paths 6784184
Length Of Smallest Path 3
Average Path Length 56.1462
Length of Longest Path 91
Minimum Path Strength 1.14
Average Path Strength 4.94846
Maximum Path Strength 27.5
Minimum Path Correlation 0.7
Average Path Correlation 0.993593
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.53846
Average % Of Corr. Nodes 27.0326
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.1074
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ03113
Sequence
>7X10_Chain_A
SAEDKAAVE RSKMIDALL ARERRAVRR LVKILLLGA DNSGKSTFL 
KQMRIIHVN KGIVEHDFV IKKIPFKMV DVSQRQKWF QCFDGITSI 
LFMVDSSDN RLVESMNDF ETIVNNKLF FNVSIILFL NKMDLLVEK 
VKTVSIKKH FPDFRGDPH RLEDVQRYL VQCFDRKRR NRSKPLFHH 
FTTSIDTEN ARFIFHAVK DTILQENLK DIML


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7X10_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7X10_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ80TS3
Sequence
>7X10_Chain_R
TNFAVLMAH VEVKHSDAV HDLLLDVIT WVGILLSLV CLLICIFTF 
CFFRGLQSD RNTIHKNLC ISLFVAELL FLIGINRTD QPIACAVFA 
ALLHFFFLA AFTWMFLEG VQLYIMLVE VFESEHSRR KYFYLVGYG 
MPALIVAVS AAVDYRSYG TDKVCWLRL DTYFIWSFI GPATLIIML 
NVIFLGIAL YKMFHHTWV IGAIALLCL LGLTWAFGL MYINESTVI 
MAYLFTIFN SLQGMFIFI FHCVLQKKV RKEYGKCLR T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SF7B2AdhesionAdhesionADGRL3Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;22.92022-04-2710.1038/s41586-022-04575-7
7WY5B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs-CtGq)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WY8B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-Gs)/&β;1/&γ;22.832022-10-2610.1016/j.molcel.2022.10.009
7WYBB2AdhesionAdhesionADGRL3Mus musculus--Gi1/&β;1/&γ;22.972022-10-2610.1016/j.molcel.2022.10.009
7X10B2AdhesionAdhesionADGRL3Mus musculus--chim(NtGi1-G12)/&β;1/&γ;22.932022-10-2610.1016/j.molcel.2022.10.009
8JMTB2AdhesionAdhesionADGRL3Homo sapiens---3.32023-09-0610.1038/s41589-023-01389-0




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7X10.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.