psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D861	R:R:N919	2.69	No	No	0	4	6
2	R:R:D861	R:R:S1078	5.89	No	No	0	4	5
3	R:R:D865	R:R:T868	4.34	Yes	No	2	5	8
4	R:R:D865	R:R:W869	14.52	Yes	No	0	5	5
5	R:R:D865	R:R:I918	2.8	Yes	No	0	5	8
6	R:R:D865	R:R:Y1074	3.45	Yes	Yes	2	5	7
7	R:R:I867	R:R:Y1084	9.67	No	No	0	8	8
8	R:R:I867	R:R:T1087	6.08	No	No	0	8	8
9	R:R:T868	R:R:Y1074	13.73	No	Yes	2	8	7
10	R:R:T1087	R:R:T868	3.14	No	No	0	8	8
11	R:R:L915	R:R:W869	3.42	No	No	0	9	5
12	R:R:E911	R:R:I872	6.83	Yes	No	0	9	9
13	R:R:I872	R:R:L915	9.99	No	No	0	9	9
14	R:R:L873	R:R:V877	2.98	No	No	0	6	8
15	R:R:C878	R:R:L874	3.17	No	No	0	8	6
16	R:R:L874	R:R:S1091	4.5	No	No	0	6	7
17	R:R:E911	R:R:S875	4.31	Yes	No	2	9	9
18	R:R:N1090	R:R:S875	2.98	Yes	No	2	9	9
19	R:R:F908	R:R:L876	3.65	No	No	0	8	9
20	R:R:E911	R:R:L876	2.65	Yes	No	0	9	9
21	R:R:I881	R:R:V877	3.07	No	No	0	5	8
22	R:R:I883	R:R:L879	2.85	No	Yes	0	7	9
23	R:R:C904	R:R:L879	3.17	No	Yes	0	8	9
24	R:R:L879	R:R:L907	2.77	Yes	No	0	9	9
25	R:R:I1097	R:R:L879	5.71	Yes	Yes	0	8	9
26	R:R:F1098	R:R:I881	6.28	No	No	0	6	5
27	R:R:C882	R:R:T885	5.07	No	Yes	0	6	9
28	R:R:C882	R:R:F1098	2.79	No	No	0	6	6
29	R:R:C1102	R:R:C882	7.28	No	No	0	9	6
30	R:R:F908	R:R:I883	5.02	No	No	0	8	7
31	R:R:F884	R:R:T885	5.19	No	Yes	0	8	9
32	R:R:F884	R:R:F888	4.29	No	No	0	8	8
33	R:R:F889	R:R:T885	3.89	Yes	Yes	0	8	9
34	R:R:T885	R:R:V1108	3.17	Yes	No	0	9	9
35	R:R:F886	R:R:N897	10.87	Yes	Yes	0	9	8
36	R:R:F886	R:R:H900	3.39	Yes	Yes	0	9	9
37	R:R:F886	R:R:K901	6.2	Yes	No	0	9	9
38	R:R:C904	R:R:F886	2.79	No	Yes	0	8	9
39	R:R:C1102	R:R:F886	2.79	No	Yes	0	9	9
40	R:R:C887	R:R:R890	2.79	No	No	0	9	8
41	R:R:C887	R:R:K901	6.47	No	No	0	9	9
42	R:R:F888	R:R:F889	4.29	No	Yes	0	8	8
43	R:R:F889	R:R:L892	6.09	Yes	Yes	0	8	8
44	R:R:F889	R:R:Y1112	5.16	Yes	No	0	8	5
45	R:R:C1115	R:R:F889	4.19	No	Yes	0	9	8
46	R:R:L892	R:R:N897	2.75	Yes	Yes	0	8	8
47	R:R:K1107	R:R:L892	5.64	No	Yes	0	9	8
48	R:R:L892	R:R:V1108	5.96	Yes	No	0	8	9
49	R:R:E1111	R:R:L892	3.98	No	Yes	0	7	8
50	R:R:N897	R:R:Q893	5.28	Yes	No	0	8	9
51	R:R:K901	R:R:Q893	5.42	No	No	0	9	9
52	R:R:D895	R:R:Q951	6.53	No	Yes	0	9	8
53	R:R:H900	R:R:R896	10.16	Yes	Yes	1	9	9
54	R:R:E948	R:R:R896	3.49	Yes	Yes	1	9	9
55	R:R:L952	R:R:R896	6.07	Yes	Yes	1	9	9
56	R:R:M955	R:R:R896	4.96	No	Yes	0	8	9
57	R:R:R896	R:R:W1053	7	Yes	No	1	9	7
58	R:R:R967	R:R:T898	6.47	No	No	0	5	9
59	R:R:I899	R:R:W944	7.05	Yes	Yes	1	9	9
60	R:R:I899	R:R:L947	2.85	Yes	Yes	1	9	8
61	R:R:E948	R:R:I899	2.73	Yes	Yes	1	9	9
62	R:R:I899	R:R:Q951	2.74	Yes	Yes	1	9	8
63	R:R:F970	R:R:I899	3.77	No	Yes	1	5	9
64	R:R:E948	R:R:H900	16	Yes	Yes	1	9	9
65	R:R:H1101	R:R:H900	21.5	No	Yes	0	8	9
66	R:R:N902	R:R:W944	19.21	No	Yes	1	9	9
67	R:R:N902	R:R:Y971	16.28	No	No	1	9	9
68	R:R:N902	R:R:Y975	9.3	No	Yes	1	9	9
69	R:R:L903	R:R:L907	2.77	No	No	0	9	9
70	R:R:L903	R:R:M945	11.31	No	Yes	0	9	8
71	R:R:F937	R:R:S906	6.61	Yes	No	0	7	7
72	R:R:A940	R:R:S906	3.42	No	No	0	7	7
73	R:R:A941	R:R:S906	3.42	No	No	0	7	7
74	R:R:A941	R:R:L907	3.15	No	No	0	7	9
75	R:R:F937	R:R:V909	18.35	Yes	No	0	7	6
76	R:R:A910	R:R:F938	2.77	No	No	0	8	8
77	R:R:E911	R:R:W1068	7.63	Yes	Yes	2	9	9
78	R:R:E911	R:R:N1090	5.26	Yes	Yes	2	9	9
79	R:R:L913	R:R:L933	2.77	No	No	0	5	5
80	R:R:F914	R:R:W1068	10.02	No	Yes	2	8	9
81	R:R:F914	R:R:Y1074	3.09	No	Yes	2	8	7
82	R:R:F1086	R:R:F914	5.36	Yes	No	2	9	8
83	R:R:F930	R:R:I916	6.28	Yes	No	0	5	5
84	R:R:F930	R:R:G917	4.52	Yes	No	0	5	8
85	R:R:I918	R:R:N919	8.5	No	No	0	8	6
86	R:R:D922	R:R:R920	3.57	No	No	0	5	7
87	R:R:C927	R:R:T921	5.07	No	No	6	9	7
88	R:R:C999	R:R:T921	3.38	No	No	6	9	7
89	R:R:P924	R:R:Q923	3.16	No	Yes	0	4	5
90	R:R:I925	R:R:Q923	5.49	No	Yes	0	5	5
91	R:R:A926	R:R:Q923	6.06	No	Yes	0	4	5
92	R:R:A926	R:R:F930	2.77	No	Yes	0	4	5
93	R:R:C927	R:R:C999	7.28	No	No	6	9	9
94	R:R:F938	R:R:L934	6.09	No	No	0	8	8
95	R:R:L934	R:R:W1000	6.83	No	Yes	0	8	8
96	R:R:H935	R:R:V982	4.15	No	No	0	9	9
97	R:R:H935	R:R:W1000	4.23	No	Yes	3	9	8
98	R:R:F1011	R:R:H935	11.31	Yes	No	3	9	9
99	R:R:F936	R:R:F937	12.86	Yes	Yes	0	7	7
100	R:R:F936	R:R:Y975	3.09	Yes	Yes	0	7	9
101	R:R:F936	R:R:P978	4.33	Yes	Yes	0	7	9
102	R:R:F938	R:R:W1068	25.05	No	Yes	0	8	9
103	R:R:L939	R:R:P978	6.57	No	Yes	0	9	9
104	R:R:I981	R:R:L939	2.85	No	No	0	8	9
105	R:R:A940	R:R:P978	3.74	No	Yes	0	7	9
106	R:R:F942	R:R:I1019	10.05	No	No	0	9	8
107	R:R:F942	R:R:L1064	4.87	No	Yes	0	9	6
108	R:R:F946	R:R:T943	3.89	Yes	No	0	9	5
109	R:R:P978	R:R:T943	3.5	Yes	No	0	9	5
110	R:R:L947	R:R:W944	5.69	Yes	Yes	1	8	9
111	R:R:G974	R:R:W944	7.04	No	Yes	0	9	9
112	R:R:W944	R:R:Y975	10.61	Yes	Yes	1	9	9
113	R:R:L1060	R:R:M945	2.83	Yes	Yes	0	9	8
114	R:R:L1061	R:R:M945	2.83	Yes	Yes	0	8	8
115	R:R:L1064	R:R:M945	5.65	Yes	Yes	0	6	8
116	R:R:F946	R:R:L947	3.65	Yes	Yes	1	9	8
117	R:R:F946	R:R:V950	6.55	Yes	No	1	9	8
118	R:R:F946	R:R:L1021	3.65	Yes	No	1	9	5
119	R:R:F1025	R:R:F946	4.29	Yes	Yes	1	6	9
120	R:R:F970	R:R:L947	7.31	No	Yes	1	5	8
121	R:R:L947	R:R:V973	8.94	Yes	No	0	8	4
122	R:R:A1057	R:R:E948	3.02	No	Yes	0	8	9
123	R:R:I954	R:R:V950	3.07	No	No	0	8	8
124	R:R:F1025	R:R:V950	3.93	Yes	No	1	6	8
125	R:R:M955	R:R:Q951	8.16	No	Yes	0	8	8
126	R:R:F970	R:R:Q951	4.68	No	Yes	1	5	8
127	R:R:L952	R:R:W1053	5.69	Yes	No	1	9	7
128	R:R:L952	R:R:V1054	5.96	Yes	No	0	9	8
129	R:R:V957	R:R:Y953	5.05	No	No	0	8	8
130	R:R:F1025	R:R:Y953	5.16	Yes	No	0	6	8
131	R:R:K1032	R:R:Y953	4.78	No	No	0	8	8
132	R:R:I1050	R:R:M955	2.92	Yes	No	0	6	8
133	R:R:L956	R:R:M1033	8.48	No	Yes	5	8	9
134	R:R:I1050	R:R:L956	2.85	Yes	No	5	6	8
135	R:R:Y971	R:R:Y975	3.97	No	Yes	1	9	9
136	R:R:M977	R:R:P978	3.35	No	Yes	0	4	9
137	R:R:L980	R:R:M977	2.83	No	No	0	4	4
138	R:R:I981	R:R:M977	2.92	No	No	0	8	4
139	R:R:I981	R:R:P1014	3.39	No	No	0	8	9
140	R:R:L1001	R:R:W1000	10.25	No	Yes	3	8	8
141	R:R:L1003	R:R:W1000	3.42	No	Yes	3	5	8
142	R:R:I1008	R:R:W1000	3.52	No	Yes	3	7	8
143	R:R:F1011	R:R:W1000	11.02	Yes	Yes	3	9	8
144	R:R:L1072	R:R:W1000	4.56	No	Yes	3	9	8
145	R:R:I1075	R:R:W1000	5.87	No	Yes	3	6	8
146	R:R:F1007	R:R:L1001	6.09	Yes	No	0	8	8
147	R:R:I1008	R:R:L1001	4.28	No	No	3	7	8
148	R:R:D1004	R:R:R1002	3.57	No	No	0	8	7
149	R:R:I1008	R:R:L1003	2.85	No	No	3	7	5
150	R:R:L1003	R:R:N1076	6.87	No	No	0	5	5
151	R:R:D1004	R:R:Y1006	9.2	No	No	0	8	7
152	R:R:T1005	R:R:Y1006	3.75	No	No	0	7	7
153	R:R:I1012	R:R:W1009	4.7	No	No	0	9	7
154	R:R:F1011	R:R:I1012	5.02	Yes	No	0	9	9
155	R:R:A1015	R:R:F1011	2.77	No	Yes	0	7	9
156	R:R:I1012	R:R:T1016	3.04	No	No	0	9	7
157	R:R:G1013	R:R:P1014	4.06	No	No	0	9	9
158	R:R:I1019	R:R:L1061	4.28	No	Yes	0	8	8
159	R:R:I1024	R:R:L1021	2.85	No	No	0	5	5
160	R:R:F1025	R:R:L1021	4.87	Yes	No	1	6	5
161	R:R:L1026	R:R:N1022	5.49	Yes	No	0	9	8
162	R:R:L1061	R:R:N1022	6.87	Yes	No	0	8	8
163	R:R:I1024	R:R:I1028	2.94	No	No	0	5	6
164	R:R:A1057	R:R:L1026	3.15	No	Yes	0	8	9
165	R:R:I1058	R:R:L1026	5.71	No	Yes	0	6	9
166	R:R:I1028	R:R:K1032	5.82	No	No	0	6	8
167	R:R:F1034	R:R:L1030	9.74	No	No	0	4	5
168	R:R:L1030	R:R:V1054	2.98	No	No	0	5	8
169	R:R:I1055	R:R:L1030	5.71	No	No	0	5	5
170	R:R:H1035	R:R:Y1031	26.13	No	No	0	6	5
171	R:R:D1048	R:R:M1033	4.16	No	Yes	5	5	9
172	R:R:I1050	R:R:M1033	5.83	Yes	Yes	5	6	9
173	R:R:K1051	R:R:M1033	4.32	No	Yes	0	3	9
174	R:R:F1034	R:R:K1051	3.72	No	No	0	4	3
175	R:R:H1035	R:R:H1036	22.69	No	No	0	6	5
176	R:R:D1048	R:R:I1050	2.8	No	Yes	5	5	6
177	R:R:Q1105	R:R:W1053	3.29	No	No	0	8	7
178	R:R:F1096	R:R:G1056	3.01	Yes	No	4	8	7
179	R:R:F1100	R:R:G1056	4.52	Yes	No	4	7	7
180	R:R:A1059	R:R:F1096	2.77	No	Yes	0	5	8
181	R:R:L1060	R:R:Q1093	5.32	Yes	Yes	4	9	9
182	R:R:F1096	R:R:L1060	7.31	Yes	Yes	4	8	9
183	R:R:I1097	R:R:L1060	4.28	Yes	Yes	4	8	9
184	R:R:L1063	R:R:Q1093	2.66	No	Yes	0	9	9
185	R:R:F1096	R:R:L1063	3.65	Yes	No	0	8	9
186	R:R:L1064	R:R:Q1093	7.99	Yes	Yes	0	6	9
187	R:R:F1089	R:R:L1066	4.87	Yes	No	0	7	8
188	R:R:F1089	R:R:T1067	6.49	Yes	No	0	7	9
189	R:R:N1090	R:R:T1067	5.85	Yes	No	0	9	9
190	R:R:G1071	R:R:W1068	2.81	No	Yes	2	9	9
191	R:R:F1086	R:R:W1068	7.02	Yes	Yes	2	9	9
192	R:R:F1070	R:R:M1082	11.2	No	No	0	8	7
193	R:R:F1070	R:R:F1086	3.22	No	Yes	0	8	9
194	R:R:F1070	R:R:F1089	5.36	No	Yes	0	8	7
195	R:R:F1086	R:R:G1071	6.02	Yes	No	2	9	9
196	R:R:I1075	R:R:L1072	2.85	No	No	3	6	9
197	R:R:M1073	R:R:N1076	4.21	No	No	0	5	5
198	R:R:E1077	R:R:M1073	2.71	No	No	0	6	5
199	R:R:A1083	R:R:Y1074	5.34	No	Yes	0	9	7
200	R:R:F1086	R:R:Y1074	4.13	Yes	Yes	2	9	7
201	R:R:I1081	R:R:V1080	3.07	No	No	0	5	4
202	R:R:V1080	R:R:Y1084	3.79	No	No	0	4	8
203	R:R:I1081	R:R:M1082	7.29	No	No	0	5	7
204	R:R:I1088	R:R:L1085	4.28	No	No	0	7	9
205	R:R:F1089	R:R:L1085	3.65	Yes	No	0	7	9
206	R:R:F1086	R:R:N1090	19.33	Yes	Yes	2	9	9
207	R:R:I1097	R:R:Q1093	8.23	Yes	Yes	4	8	9
208	R:R:G1094	R:R:I1097	3.53	No	Yes	0	8	8
209	R:R:I1099	R:R:M1095	2.92	No	No	0	6	6
210	R:R:F1096	R:R:F1100	4.29	Yes	Yes	4	8	7
211	R:R:I1099	R:R:V1103	3.07	No	No	0	6	5
212	R:R:I1099	R:R:L1104	2.85	No	No	0	6	8
213	R:R:F1100	R:R:H1101	12.44	Yes	No	0	7	8
214	R:R:H1101	R:R:Q1105	3.71	No	No	0	8	8
215	R:R:Q1105	R:R:V1108	4.3	No	No	0	8	9
216	R:R:R1109	R:R:Y1112	6.17	No	No	0	7	5
217	R:R:E1111	R:R:K1114	2.7	No	No	0	7	6
218	R:R:C1115	R:R:H1119	4.42	No	No	0	9	4
219	R:R:F1007	R:R:S985	2.64	Yes	No	0	8	8
220	R:R:F1007	R:R:S1010	2.64	Yes	No	0	8	8
221	R:R:F1100	R:R:S1052	2.64	Yes	No	0	7	8
222	R:R:H1035	R:R:K1032	2.62	No	No	0	6	8
223	R:R:F1098	R:R:V1103	2.62	No	No	0	6	5
224	R:R:F942	R:R:I1018	2.51	No	No	0	9	5
225	R:R:T898	R:R:Y971	2.5	No	No	0	9	9
226	R:R:F908	R:R:L912	2.44	No	No	0	8	7
227	R:R:F930	R:R:L913	2.44	Yes	No	0	5	5
228	R:R:F937	R:R:L933	2.44	Yes	No	0	7	5
229	R:R:D895	R:R:R966	2.38	No	No	0	9	9
230	R:R:F1007	R:R:Y1006	2.06	Yes	No	0	8	7
231	R:R:C878	R:R:G1094	1.96	No	No	0	8	8
232	R:R:A979	R:R:G976	1.95	No	No	0	7	5
233	R:R:G871	R:R:V870	1.84	No	No	0	9	8
234	R:R:G871	R:R:T1087	1.82	No	No	0	9	8
235	R:R:G949	R:R:L952	1.71	No	Yes	0	6	9
236	R:R:G949	R:R:L1026	1.71	No	Yes	0	6	9
237	R:R:G1065	R:R:L1064	1.71	No	Yes	0	6	6
238	R:R:G1113	R:R:L1116	1.71	No	No	0	6	4
239	R:R:A1029	R:R:V1054	1.7	No	No	0	8	8
240	R:R:A1083	R:R:L864	1.58	No	No	0	9	7
241	R:R:I905	R:R:V909	1.54	No	No	0	6	6
242	R:R:I1075	R:R:V998	1.54	No	No	0	6	6
243	R:R:M1073	R:R:T1079	1.51	No	No	0	5	8
244	R:R:M1082	R:R:T1079	1.51	No	No	0	7	8
245	R:R:G1113	R:R:R1109	1.5	No	No	0	6	7
246	R:R:G1113	R:R:R1117	1.5	No	No	0	6	8
247	R:R:K1114	R:R:T1118	1.5	No	No	0	6	5
248	R:R:N897	R:R:S894	1.49	Yes	No	0	8	8
249	R:R:L933	R:R:V929	1.49	No	No	0	5	7
250	R:R:L972	R:R:V973	1.49	No	No	0	4	4
251	R:R:L980	R:R:V984	1.49	No	No	0	4	7
252	R:R:L1061	R:R:V1023	1.49	Yes	No	0	8	5
253	R:R:I883	R:R:L880	1.43	No	No	0	7	5
254	R:R:A979	R:R:F936	1.39	No	Yes	0	7	7
255	R:R:L1063	R:R:L1092	1.38	No	No	0	9	4
256	R:R:D1048	R:R:N1049	1.35	No	No	0	5	6
257	R:R:D922	R:R:Q923	1.31	No	Yes	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D865	6.2775	4	2	5
2	R:R:L879	3.625	4	0	9
3	R:R:T885	4.33	4	0	9
4	R:R:F886	5.208	5	0	9
5	R:R:F889	4.724	5	0	8
6	R:R:L892	4.884	5	0	8
7	R:R:R896	6.336	5	1	9
8	R:R:N897	5.0975	4	0	8
9	R:R:I899	3.828	5	1	9
10	R:R:H900	12.7625	4	1	9
11	R:R:E911	5.336	5	2	9
12	R:R:Q923	4.005	4	0	5
13	R:R:F930	4.0025	4	0	5
14	R:R:F936	5.4175	4	0	7
15	R:R:F937	10.065	4	0	7
16	R:R:W944	9.92	5	1	9
17	R:R:M945	5.655	4	0	8
18	R:R:F946	4.406	5	1	9
19	R:R:L947	5.688	5	1	8
20	R:R:E948	6.31	4	1	9
21	R:R:Q951	5.5275	4	1	8
22	R:R:L952	4.8575	4	1	9
23	R:R:Y975	6.7425	4	1	9
24	R:R:P978	4.298	5	0	9
25	R:R:W1000	6.2125	8	3	8
26	R:R:F1007	3.3575	4	0	8
27	R:R:F1011	7.53	4	3	9
28	R:R:F1025	4.5625	4	1	6
29	R:R:L1026	4.015	4	0	9
30	R:R:M1033	5.6975	4	5	9
31	R:R:I1050	3.6	4	5	6
32	R:R:L1060	4.935	4	4	9
33	R:R:L1061	3.8675	4	0	8
34	R:R:L1064	5.055	4	0	6
35	R:R:W1068	10.506	5	2	9
36	R:R:Y1074	5.948	5	2	7
37	R:R:F1086	7.51333	6	2	9
38	R:R:F1089	5.0925	4	0	7
39	R:R:N1090	8.355	4	2	9
40	R:R:Q1093	6.05	4	4	9
41	R:R:F1096	4.206	5	4	8
42	R:R:I1097	5.4375	4	4	8
43	R:R:F1100	5.9725	4	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I918	R:R:N919	13.1551	8.5	No	No	0	8	6
2	R:R:D865	R:R:I918	16.6859	2.8	Yes	No	0	5	8
3	R:R:D865	R:R:Y1074	15.817	3.45	Yes	Yes	2	5	7
4	R:R:T1087	R:R:T868	16.6419	3.14	No	No	0	8	8
5	R:R:F914	R:R:Y1074	14.882	3.09	No	Yes	2	8	7
6	R:R:F914	R:R:W1068	15.8995	10.02	No	Yes	2	8	9
7	R:R:E911	R:R:W1068	61.8875	7.63	Yes	Yes	2	9	9
8	R:R:F1086	R:R:Y1074	29.5166	4.13	Yes	Yes	2	9	7
9	R:R:F1086	R:R:W1068	24.9024	7.02	Yes	Yes	2	9	9
10	R:R:F1086	R:R:N1090	22.8675	19.33	Yes	Yes	2	9	9
11	R:R:E911	R:R:N1090	28.4662	5.26	Yes	Yes	2	9	9
12	R:R:E911	R:R:L876	98.1026	2.65	Yes	No	0	9	9
13	R:R:F908	R:R:L876	98.5041	3.65	No	No	0	8	9
14	R:R:F908	R:R:I883	99.274	5.02	No	No	0	8	7
15	R:R:I883	R:R:L879	100	2.85	No	Yes	0	7	9
16	R:R:C904	R:R:L879	61.288	3.17	No	Yes	0	8	9
17	R:R:C904	R:R:F886	60.8425	2.79	No	Yes	0	8	9
18	R:R:C1102	R:R:F886	16.5979	2.79	No	Yes	0	9	9
19	R:R:C1102	R:R:C882	15.531	7.28	No	No	0	9	6
20	R:R:C882	R:R:F1098	13.4301	2.79	No	No	0	6	6
21	R:R:I1097	R:R:L879	23.2855	5.71	Yes	Yes	0	8	9
22	R:R:L879	R:R:L907	45.922	2.77	Yes	No	0	9	9
23	R:R:F886	R:R:N897	22.983	10.87	Yes	Yes	0	9	8
24	R:R:L892	R:R:N897	19.1113	2.75	Yes	Yes	0	8	8
25	R:R:F889	R:R:L892	14.2991	6.09	Yes	Yes	0	8	8
26	R:R:F886	R:R:H900	45.5095	3.39	Yes	Yes	0	9	9
27	R:R:H900	R:R:R896	15.2505	10.16	Yes	Yes	1	9	9
28	R:R:M955	R:R:R896	11.0763	4.96	No	Yes	0	8	9
29	R:R:E948	R:R:H900	33.0803	16	Yes	Yes	1	9	9
30	R:R:E948	R:R:I899	37.5516	2.73	Yes	Yes	1	9	9
31	R:R:A941	R:R:L907	42.6387	3.15	No	No	0	7	9
32	R:R:A941	R:R:S906	41.8908	3.42	No	No	0	7	7
33	R:R:F937	R:R:S906	20.6017	6.61	Yes	No	0	7	7
34	R:R:F936	R:R:F937	11.9837	12.86	Yes	Yes	0	7	7
35	R:R:F936	R:R:Y975	13.7051	3.09	Yes	Yes	0	7	9
36	R:R:I899	R:R:W944	15.1625	7.05	Yes	Yes	1	9	9
37	R:R:I899	R:R:L947	22.356	2.85	Yes	Yes	1	9	8
38	R:R:A940	R:R:S906	20.8436	3.42	No	No	0	7	7
39	R:R:F938	R:R:W1068	28.5926	25.05	No	Yes	0	8	9
40	R:R:F937	R:R:L933	16.8289	2.44	Yes	No	0	7	5
41	R:R:L913	R:R:L933	14.2386	2.77	No	No	0	5	5
42	R:R:F930	R:R:L913	12.8637	2.44	Yes	No	0	5	5
43	R:R:F938	R:R:L934	26.3323	6.09	No	No	0	8	8
44	R:R:L934	R:R:W1000	25.3699	6.83	No	Yes	0	8	8
45	R:R:A940	R:R:P978	20.3487	3.74	No	Yes	0	7	9
46	R:R:M977	R:R:P978	12.0442	3.35	No	Yes	0	4	9
47	R:R:L1061	R:R:M945	11.1203	2.83	Yes	Yes	0	8	8
48	R:R:F946	R:R:L947	21.9876	3.65	Yes	Yes	1	9	8
49	R:R:P978	R:R:T943	17.0214	3.5	Yes	No	0	9	5
50	R:R:F946	R:R:T943	16.7354	3.89	Yes	No	0	9	5
51	R:R:F1025	R:R:F946	14.0956	4.29	Yes	Yes	1	6	9
52	R:R:F1025	R:R:Y953	12.1267	5.16	Yes	No	0	6	8
53	R:R:I1050	R:R:M955	10.8233	2.92	Yes	No	0	6	8
54	R:R:L1001	R:R:W1000	10.3503	10.25	No	Yes	3	8	8
55	R:R:F1070	R:R:F1086	17.8188	3.22	No	Yes	0	8	9
56	R:R:F1070	R:R:M1082	15.025	11.2	No	No	0	8	7
57	R:R:T868	R:R:Y1074	19.4412	13.73	No	Yes	2	8	7
58	R:R:W944	R:R:Y975	11.6812	10.61	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8JMT

PDB Summary
PDB	8JMT
Class	B2
SubFamily	Adhesion
Type	Adhesion
SubType	ADGRL3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.3
Date	2023-09-06
D.O.I.	doi.org/10.1038/s41589-023-01389-0

Net Summary
I_min	2.65
Number of Linked Nodes	211
Number of Links	257
Number of Hubs	43
Number of Links mediated by Hubs	153
Number of Communities	6
Number of Nodes involved in Communities	48
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	35441
Length Of Smallest Path	3
Average Path Length	12.8172
Length of Longest Path	26
Minimum Path Strength	1.5
Average Path Strength	5.34773
Maximum Path Strength	24.41
Minimum Path Correlation	0.7
Average Path Correlation	0.909266
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	41.0702
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.388
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • ion binding • binding • calcium ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • molecular condensate scaffold activity • protein-macromolecule adaptor activity • molecular adaptor activity • cell adhesion molecule binding • protein binding • cell adhesion mediator activity • carbohydrate binding • developmental process • multicellular organismal process • nervous system development • excitatory synapse assembly • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • cellular process • synapse organization • cellular component organization or biogenesis
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • nervous system development • excitatory synapse assembly • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • cellular process • synapse organization • cellular component organization or biogenesis • synapse assembly • system development • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • Rho-activating G protein-coupled receptor signaling pathway • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • cellular anatomical structure • membrane • cell-cell junction • anchoring junction • cell junction • cell periphery • plasma membrane • synapse • glutamatergic synapse • axon • cell projection • neuron projection • plasma membrane bounded cell projection
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9HAR2
Sequence	>8JMT_Chain_R D L L L D V I T W V G I L L S L V C L L I C I F T F C F F R G L Q S D R N T I H K N L C I S L F V A E L L F L I G I N R T D Q P I A C A V F A A L L H F F F L A A F T W M F L E G V Q L Y I M L V E S R R K Y F Y L V G Y G M P A L I V A V S A A V V C W L R L D T Y F I W S F I G P A T L I I M L N V I F L G I A L Y K M F H H D N I K S W V I G A I A L L C L L G L T W A F G L M Y I N E S T V I M A Y L F T I F N S L Q G M F I F I F H C V L Q K K V R K E Y G K C L R T H A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WY5	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY5 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY8	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY8 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WYB	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	Gi1/β1/γ2	2.97	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WYB (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.97	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7X10	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-G12)/β1/γ2	2.93	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7X10 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.93	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7SF7	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	2.9	2022-04-27	doi.org/10.1038/s41586-022-04575-7
	7SF7 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-		2.9	2022-04-27	doi.org/10.1038/s41586-022-04575-7
	8JMT	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	-	3.3	2023-09-06	doi.org/10.1038/s41589-023-01389-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JMT.zip

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