psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D946	R:R:T923	8.67	No	No	0	4	9
2	R:R:T923	R:R:V1079	3.17	No	No	0	9	5
3	R:R:A926	R:R:N924	3.13	No	Yes	0	9	8
4	R:R:N924	R:R:V927	4.43	Yes	No	0	8	7
5	R:R:L945	R:R:N924	6.87	No	Yes	0	8	8
6	R:R:D946	R:R:N924	4.04	No	Yes	0	4	8
7	R:R:N924	R:R:T949	2.92	Yes	No	0	8	8
8	R:R:F925	R:R:L928	4.87	Yes	Yes	0	9	9
9	R:R:F925	R:R:T949	5.19	Yes	No	0	9	8
10	R:R:F925	R:R:W1158	6.01	Yes	Yes	2	9	8
11	R:R:F1176	R:R:F925	6.43	Yes	Yes	2	9	9
12	R:R:F925	R:R:N1180	9.67	Yes	Yes	2	9	9
13	R:R:F995	R:R:L928	8.53	No	Yes	0	8	9
14	R:R:F1019	R:R:L928	7.31	No	Yes	0	9	9
15	R:R:L928	R:R:W1081	3.42	Yes	Yes	0	9	6
16	R:R:I1093	R:R:M929	2.92	Yes	No	0	8	9
17	R:R:M929	R:R:W1158	3.49	No	Yes	2	9	8
18	R:R:F1176	R:R:M929	4.98	Yes	No	2	9	9
19	R:R:K935	R:R:V932	4.55	No	No	0	2	5
20	R:R:V932	R:R:Y1164	10.09	No	Yes	0	5	6
21	R:R:H936	R:R:V934	4.15	No	No	0	1	4
22	R:R:D942	R:R:K935	4.15	No	No	0	4	2
23	R:R:H941	R:R:S937	11.16	Yes	No	0	5	1
24	R:R:A939	R:R:H941	2.93	No	Yes	0	1	5
25	R:R:L944	R:R:V940	2.98	No	No	0	5	4
26	R:R:E1167	R:R:H941	7.39	No	Yes	0	5	5
27	R:R:H941	R:R:V1170	5.54	Yes	No	0	5	4
28	R:R:L943	R:R:V947	2.98	No	No	0	4	6
29	R:R:L944	R:R:Y1174	5.86	No	No	0	5	9
30	R:R:L945	R:R:Y1174	7.03	No	No	0	8	9
31	R:R:D946	R:R:W950	8.93	No	No	0	4	7
32	R:R:I948	R:R:T1177	7.6	No	No	0	9	9
33	R:R:T1177	R:R:T949	3.14	No	No	0	9	8
34	R:R:L996	R:R:W950	3.42	No	No	0	9	7
35	R:R:G952	R:R:L955	3.42	No	No	0	9	6
36	R:R:G952	R:R:S1181	3.71	No	No	0	9	7
37	R:R:I953	R:R:L957	2.85	No	No	0	9	9
38	R:R:I953	R:R:L996	2.85	No	No	0	9	9
39	R:R:L1182	R:R:L955	5.54	No	No	0	6	6
40	R:R:L960	R:R:S956	3	Yes	No	0	9	9
41	R:R:E992	R:R:S956	8.62	No	No	0	9	9
42	R:R:E992	R:R:L957	7.95	No	No	0	9	9
43	R:R:C959	R:R:F1188	8.38	No	Yes	0	9	7
44	R:R:C963	R:R:L960	3.17	Yes	Yes	1	7	9
45	R:R:I964	R:R:L960	5.71	No	Yes	1	7	9
46	R:R:C985	R:R:L960	3.17	No	Yes	1	9	9
47	R:R:L960	R:R:L988	4.15	Yes	No	0	9	9
48	R:R:C963	R:R:F967	6.98	Yes	Yes	1	7	9
49	R:R:C963	R:R:C985	3.64	Yes	No	1	7	9
50	R:R:C1192	R:R:C963	3.64	No	Yes	1	9	7
51	R:R:C985	R:R:I964	3.27	No	No	1	9	7
52	R:R:I964	R:R:I986	2.94	No	No	0	7	5
53	R:R:F965	R:R:T966	3.89	No	Yes	0	8	9
54	R:R:F965	R:R:F969	5.36	No	No	0	8	8
55	R:R:F967	R:R:T966	3.89	Yes	Yes	1	9	9
56	R:R:F970	R:R:T966	3.89	Yes	Yes	1	8	9
57	R:R:T966	R:R:Y1202	13.73	Yes	Yes	1	9	7
58	R:R:F967	R:R:N978	6.04	Yes	No	0	9	9
59	R:R:F967	R:R:H981	11.31	Yes	Yes	1	9	9
60	R:R:C1192	R:R:F967	4.19	No	Yes	1	9	9
61	R:R:C968	R:R:K982	4.85	No	No	0	8	9
62	R:R:F969	R:R:F970	16.08	No	Yes	0	8	8
63	R:R:F970	R:R:Y1202	16.5	Yes	Yes	1	8	7
64	R:R:C1205	R:R:F970	4.19	No	Yes	0	8	8
65	R:R:F970	R:R:L1206	6.09	Yes	No	0	8	5
66	R:R:L973	R:R:N978	5.49	No	No	0	8	9
67	R:R:E1201	R:R:L973	5.3	No	No	0	8	8
68	R:R:N978	R:R:Q974	3.96	No	No	0	9	9
69	R:R:D976	R:R:Q1032	3.92	Yes	Yes	0	9	8
70	R:R:D976	R:R:R1048	4.76	Yes	Yes	0	9	4
71	R:R:H981	R:R:R977	4.51	Yes	No	1	9	9
72	R:R:Q1032	R:R:R977	4.67	Yes	No	1	8	9
73	R:R:M1036	R:R:R977	6.2	No	No	1	8	9
74	R:R:I980	R:R:W1025	7.05	No	Yes	0	9	9
75	R:R:E1029	R:R:I980	5.47	No	No	0	9	9
76	R:R:I980	R:R:Q1032	4.12	No	Yes	0	9	8
77	R:R:E1029	R:R:H981	11.08	No	Yes	1	9	9
78	R:R:H981	R:R:L1153	3.86	Yes	Yes	1	9	9
79	R:R:K982	R:R:N983	6.99	No	No	0	9	9
80	R:R:N983	R:R:W1025	13.56	No	Yes	0	9	9
81	R:R:N983	R:R:Y1052	10.47	No	No	0	9	9
82	R:R:L984	R:R:W1025	5.69	No	Yes	0	9	9
83	R:R:L984	R:R:M1026	7.07	No	No	0	9	8
84	R:R:S987	R:R:Y1056	3.82	No	No	0	8	9
85	R:R:F1018	R:R:V990	7.87	No	No	0	8	5
86	R:R:A991	R:R:F1018	4.16	No	No	0	8	8
87	R:R:A991	R:R:F1019	4.16	No	No	0	8	9
88	R:R:L1015	R:R:L994	6.92	No	No	0	9	5
89	R:R:F995	R:R:I999	13.82	No	No	0	8	8
90	R:R:G998	R:R:I997	3.53	No	No	0	9	5
91	R:R:F1011	R:R:G998	6.02	No	No	0	5	9
92	R:R:I999	R:R:N1000	7.08	No	No	0	8	6
93	R:R:I999	R:R:V1079	6.14	No	No	0	8	5
94	R:R:F1011	R:R:R1001	11.76	No	No	0	5	8
95	R:R:C1080	R:R:T1002	5.07	No	No	0	8	7
96	R:R:D1003	R:R:Q1004	7.83	No	No	0	4	4
97	R:R:A1007	R:R:Q1004	3.03	No	No	0	4	4
98	R:R:C1008	R:R:C1080	7.28	No	No	0	9	8
99	R:R:A1012	R:R:Y1074	4	No	Yes	0	9	9
100	R:R:L1015	R:R:W1081	6.83	No	Yes	0	9	6
101	R:R:H1016	R:R:S1091	8.37	No	No	0	9	9
102	R:R:F1017	R:R:F1018	5.36	Yes	No	0	8	8
103	R:R:F1017	R:R:P1059	7.22	Yes	Yes	0	8	9
104	R:R:F1017	R:R:V1063	5.24	Yes	No	0	8	9
105	R:R:F1019	R:R:F1092	5.36	No	No	0	9	9
106	R:R:L1020	R:R:P1059	4.93	No	Yes	0	9	9
107	R:R:I1062	R:R:L1020	5.71	No	No	0	8	9
108	R:R:L1020	R:R:P1095	3.28	No	No	0	9	9
109	R:R:A1021	R:R:P1059	3.74	No	Yes	0	8	9
110	R:R:A1096	R:R:F1023	4.16	No	No	0	8	9
111	R:R:F1023	R:R:W1158	4.01	No	Yes	0	9	8
112	R:R:M1058	R:R:T1024	3.01	No	No	0	4	5
113	R:R:L1028	R:R:W1025	9.11	No	Yes	0	7	9
114	R:R:W1025	R:R:Y1056	3.86	Yes	No	0	9	9
115	R:R:M1026	R:R:Q1183	5.44	No	No	0	8	9
116	R:R:F1027	R:R:V1031	5.24	No	No	0	9	9
117	R:R:F1027	R:R:I1099	3.77	No	No	0	9	5
118	R:R:F1027	R:R:L1102	3.65	No	No	0	9	4
119	R:R:E1029	R:R:L1153	6.63	No	Yes	1	9	9
120	R:R:F1106	R:R:G1030	3.01	No	No	0	6	5
121	R:R:G1030	R:R:L1154	3.42	No	No	0	5	6
122	R:R:F1106	R:R:V1031	3.93	No	No	0	6	9
123	R:R:I1035	R:R:Q1032	8.23	No	Yes	1	7	8
124	R:R:M1036	R:R:Q1032	6.8	No	Yes	1	8	8
125	R:R:A1110	R:R:L1033	4.73	No	Yes	0	8	9
126	R:R:I1035	R:R:Y1034	3.63	No	No	1	7	8
127	R:R:V1038	R:R:Y1034	10.09	No	No	0	8	8
128	R:R:E1039	R:R:Y1034	7.86	No	No	1	8	8
129	R:R:E1039	R:R:I1035	5.47	No	No	1	8	7
130	R:R:F1041	R:R:V1040	9.18	No	No	0	9	9
131	R:R:H1045	R:R:R1047	6.77	No	No	0	4	9
132	R:R:R1047	R:R:Y1050	6.17	No	No	0	9	9
133	R:R:R1048	R:R:Y1052	3.09	Yes	No	0	4	9
134	R:R:K1049	R:R:Y1050	8.36	No	No	0	8	9
135	R:R:Y1052	R:R:Y1056	2.98	No	No	0	9	9
136	R:R:G1055	R:R:V1054	3.68	No	No	0	8	4
137	R:R:S1066	R:R:S1091	3.26	No	No	0	9	9
138	R:R:D1070	R:R:R1072	10.72	No	No	0	9	4
139	R:R:D1070	R:R:F1088	7.17	No	No	0	9	8
140	R:R:R1072	R:R:Y1071	9.26	No	No	0	4	8
141	R:R:S1073	R:R:Y1074	5.09	No	Yes	0	9	9
142	R:R:L1082	R:R:S1073	3	No	No	0	8	9
143	R:R:F1088	R:R:S1073	6.61	No	No	0	8	9
144	R:R:C1080	R:R:G1075	3.92	No	No	0	8	9
145	R:R:R1083	R:R:T1076	5.17	No	No	0	5	9
146	R:R:D1077	R:R:R1083	5.96	No	No	0	1	5
147	R:R:L1082	R:R:W1081	4.56	No	Yes	3	8	6
148	R:R:I1089	R:R:W1081	3.52	Yes	Yes	3	9	6
149	R:R:F1092	R:R:W1081	10.02	No	Yes	0	9	6
150	R:R:I1089	R:R:L1082	4.28	Yes	No	3	9	8
151	R:R:D1085	R:R:R1083	19.06	No	No	0	8	5
152	R:R:I1089	R:R:L1084	4.28	Yes	No	0	9	5
153	R:R:D1085	R:R:T1086	7.23	No	No	0	8	8
154	R:R:F1088	R:R:T1086	11.67	No	No	0	8	8
155	R:R:I1089	R:R:I1093	2.94	Yes	Yes	0	9	8
156	R:R:G1094	R:R:P1095	4.06	No	No	0	9	9
157	R:R:L1098	R:R:T1097	2.95	No	No	0	5	6
158	R:R:I1100	R:R:L1156	4.28	No	No	0	9	6
159	R:R:L1102	R:R:M1101	5.65	No	No	0	4	4
160	R:R:L1154	R:R:N1103	21.97	No	No	0	6	9
161	R:R:L1107	R:R:L1150	4.15	No	No	5	8	9
162	R:R:L1111	R:R:W1143	3.42	No	No	0	5	7
163	R:R:H1117	R:R:K1113	3.93	No	No	0	6	7
164	R:R:M1114	R:R:W1143	5.82	No	No	0	8	7
165	R:R:H1116	R:R:H1117	8.36	No	No	0	5	6
166	R:R:I1148	R:R:V1144	3.07	No	No	0	5	8
167	R:R:F1190	R:R:I1148	5.02	Yes	No	0	8	5
168	R:R:A1149	R:R:F1190	5.55	No	Yes	1	5	8
169	R:R:A1149	R:R:H1191	2.93	No	Yes	1	5	8
170	R:R:L1151	R:R:L1156	4.15	No	No	0	9	6
171	R:R:C1152	R:R:I1187	4.91	No	No	0	6	9
172	R:R:C1152	R:R:F1190	5.59	No	Yes	1	6	8
173	R:R:C1152	R:R:H1191	2.95	No	Yes	1	6	8
174	R:R:I1187	R:R:L1153	4.28	No	Yes	0	9	9
175	R:R:H1191	R:R:L1153	10.29	Yes	Yes	1	8	9
176	R:R:F1160	R:R:T1157	5.19	No	No	2	8	9
177	R:R:F1179	R:R:T1157	10.38	No	No	2	8	9
178	R:R:N1180	R:R:T1157	5.85	Yes	No	2	9	9
179	R:R:F1176	R:R:W1158	4.01	Yes	Yes	2	9	8
180	R:R:N1180	R:R:W1158	23.73	Yes	Yes	2	9	8
181	R:R:F1160	R:R:L1175	14.61	No	No	2	8	9
182	R:R:F1160	R:R:F1179	5.36	No	No	2	8	8
183	R:R:F1176	R:R:G1161	6.02	Yes	No	0	9	9
184	R:R:T1169	R:R:Y1164	8.74	No	Yes	4	8	6
185	R:R:M1172	R:R:Y1164	5.99	No	Yes	4	8	6
186	R:R:I1165	R:R:N1166	9.91	No	No	0	6	7
187	R:R:M1172	R:R:T1169	6.02	No	No	4	8	8
188	R:R:I1171	R:R:V1170	3.07	No	No	0	6	4
189	R:R:V1170	R:R:Y1174	5.05	No	No	0	4	9
190	R:R:F1179	R:R:L1175	3.65	No	No	2	8	9
191	R:R:F1176	R:R:N1180	7.25	Yes	Yes	2	9	9
192	R:R:L1182	R:R:S1181	3	No	No	0	6	7
193	R:R:G1184	R:R:I1187	3.53	No	No	0	8	9
194	R:R:F1186	R:R:M1185	6.22	No	No	0	8	7
195	R:R:I1189	R:R:M1185	2.92	No	No	0	7	7
196	R:R:C1192	R:R:F1188	13.97	No	Yes	0	9	7
197	R:R:F1188	R:R:V1193	3.93	Yes	No	0	7	5
198	R:R:I1189	R:R:L1194	2.85	No	No	0	7	9
199	R:R:F1190	R:R:H1191	5.66	Yes	Yes	1	8	8
200	R:R:Q1195	R:R:V1198	2.87	No	No	0	8	9
201	R:R:V1198	R:R:Y1202	7.57	No	Yes	0	9	7
202	R:R:G1203	R:R:R1207	4.5	No	No	0	5	8
203	R:R:L1182	R:R:M1185	2.83	No	No	0	6	7
204	R:R:L957	R:R:L993	2.77	No	No	0	9	5
205	R:R:L993	R:R:L996	2.77	No	No	0	5	9
206	R:R:H1016	R:R:V1063	2.77	No	No	0	9	9
207	R:R:A1060	R:R:F1017	2.77	No	Yes	0	7	8
208	R:R:A1013	R:R:Y1074	2.67	No	Yes	0	8	9
209	R:R:A1173	R:R:Y1164	2.67	No	Yes	0	9	6
210	R:R:F989	R:R:V990	2.62	No	No	0	8	5
211	R:R:R1048	R:R:T979	2.59	Yes	No	0	4	9
212	R:R:F1188	R:R:I962	2.51	Yes	No	0	7	5
213	R:R:F1023	R:R:I1099	2.51	No	No	0	9	5
214	R:R:K1196	R:R:R1199	2.48	No	No	0	9	7
215	R:R:V1144	R:R:W1143	2.45	No	No	0	8	7
216	R:R:F1190	R:R:L1194	2.44	Yes	No	0	8	9
217	R:R:D976	R:R:F1051	2.39	Yes	No	0	9	5
218	R:R:K1113	R:R:Y1112	2.39	No	No	0	7	4
219	R:R:G1057	R:R:P1059	2.03	No	Yes	0	6	9
220	R:R:A1149	R:R:G1146	1.95	No	No	0	5	8
221	R:R:G1055	R:R:T1024	1.82	No	No	0	8	5
222	R:R:G1075	R:R:T1076	1.82	No	No	0	9	9
223	R:R:A926	R:R:A930	1.79	No	No	0	9	7
224	R:R:G1146	R:R:I1145	1.76	No	No	0	8	6
225	R:R:P1059	R:R:T1024	1.75	Yes	No	0	9	5
226	R:R:G1161	R:R:M1172	1.75	No	No	0	9	8
227	R:R:G1030	R:R:L1033	1.71	No	Yes	0	5	9
228	R:R:I1006	R:R:P1005	1.69	No	No	0	6	3
229	R:R:E1201	R:R:G972	1.64	No	No	0	8	9
230	R:R:G1155	R:R:Q1183	1.64	No	No	0	6	9
231	R:R:V947	R:R:V951	1.6	No	No	0	6	8
232	R:R:V1065	R:R:V1069	1.6	No	No	0	8	7
233	R:R:S1168	R:R:T1169	1.6	No	No	0	6	8
234	R:R:A1022	R:R:L984	1.58	No	No	0	8	9
235	R:R:P1005	R:R:Q1004	1.58	No	No	0	3	4
236	R:R:A1110	R:R:L1037	1.58	No	No	0	8	8
237	R:R:A1147	R:R:L1111	1.58	No	No	0	9	5
238	R:R:A939	R:R:D938	1.54	No	No	0	1	1
239	R:R:I1109	R:R:V1038	1.54	No	No	0	6	8
240	R:R:I1105	R:R:V1104	1.54	No	No	0	5	6
241	R:R:I1093	R:R:T1097	1.52	Yes	No	0	8	6
242	R:R:I1178	R:R:T1177	1.52	No	No	0	5	9
243	R:R:L1014	R:R:V1010	1.49	No	No	0	5	6
244	R:R:L1061	R:R:V1065	1.49	No	No	0	5	8
245	R:R:N1166	R:R:S1168	1.49	No	No	0	7	6
246	R:R:N1166	R:R:V934	1.48	No	No	0	7	4
247	R:R:D976	R:R:S975	1.47	Yes	No	0	9	7
248	R:R:I1099	R:R:I1100	1.47	No	No	0	5	9
249	R:R:I1165	R:R:M1163	1.46	No	No	0	6	6
250	R:R:G1203	R:R:Y1202	1.45	No	Yes	0	5	7
251	R:R:E933	R:R:V934	1.43	No	No	0	4	4
252	R:R:I997	R:R:L993	1.43	No	No	0	5	5
253	R:R:I1093	R:R:L1162	1.43	Yes	No	0	8	8
254	R:R:I1105	R:R:L1102	1.43	No	No	0	5	4
255	R:R:K1197	R:R:L973	1.41	No	No	0	9	8
256	R:R:L943	R:R:L944	1.38	No	No	0	4	5
257	R:R:L1014	R:R:L994	1.38	No	No	0	5	5
258	R:R:L1033	R:R:L1107	1.38	Yes	No	5	9	8
259	R:R:L1033	R:R:L1150	1.38	Yes	No	5	9	9
260	R:R:A1009	R:R:Y1074	1.33	No	Yes	0	7	9
261	R:R:A1067	R:R:Y1074	1.33	No	Yes	0	8	9
262	R:R:R1048	R:R:S1046	1.32	Yes	No	0	4	9
263	R:R:R1199	R:R:V1193	1.31	No	No	0	7	5
264	R:R:H931	R:R:L1084	1.29	No	No	0	6	5
265	R:R:E1042	R:R:F1041	1.17	No	No	0	9	9
266	R:R:I1089	R:R:W1090	1.17	Yes	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N924	4.278	5	0	8
2	R:R:F925	6.434	5	2	9
3	R:R:L928	6.0325	4	0	9
4	R:R:H941	6.755	4	0	5
5	R:R:L960	3.84	5	1	9
6	R:R:C963	4.3575	4	1	7
7	R:R:T966	6.35	4	1	9
8	R:R:F967	6.482	5	1	9
9	R:R:F970	9.35	5	1	8
10	R:R:D976	3.135	4	0	9
11	R:R:H981	7.69	4	1	9
12	R:R:F1017	5.1475	4	0	8
13	R:R:W1025	7.854	5	0	9
14	R:R:Q1032	5.548	5	1	8
15	R:R:L1033	2.3	4	5	9
16	R:R:R1048	2.94	4	0	4
17	R:R:P1059	3.934	5	0	9
18	R:R:Y1074	2.884	5	0	9
19	R:R:W1081	5.67	5	3	6
20	R:R:I1089	3.238	5	3	9
21	R:R:I1093	2.2025	4	0	8
22	R:R:L1153	6.265	4	1	9
23	R:R:W1158	8.25	5	2	8
24	R:R:Y1164	6.8725	4	4	6
25	R:R:F1176	5.738	5	2	9
26	R:R:N1180	11.625	4	2	9
27	R:R:F1188	7.1975	4	0	7
28	R:R:F1190	4.852	5	1	8
29	R:R:H1191	5.4575	4	1	8
30	R:R:Y1202	9.8125	4	1	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D946	R:R:N924	96.4668	4.04	No	Yes	0	4	8
2	R:R:L945	R:R:N924	17.2321	6.87	No	Yes	0	8	8
3	R:R:N924	R:R:T949	90.9325	2.92	Yes	No	0	8	8
4	R:R:F925	R:R:T949	89.3536	5.19	Yes	No	0	9	8
5	R:R:F925	R:R:L928	53.9201	4.87	Yes	Yes	0	9	9
6	R:R:F925	R:R:W1158	26.4402	6.01	Yes	Yes	2	9	8
7	R:R:F1176	R:R:F925	20.8004	6.43	Yes	Yes	2	9	9
8	R:R:F1019	R:R:L928	26.6787	7.31	No	Yes	0	9	9
9	R:R:L928	R:R:W1081	32.4396	3.42	Yes	Yes	0	9	6
10	R:R:I1093	R:R:M929	11.0373	2.92	Yes	No	0	8	9
11	R:R:F1176	R:R:G1161	19.284	6.02	Yes	No	0	9	9
12	R:R:G1161	R:R:M1172	18.0528	1.75	No	No	0	9	8
13	R:R:M1172	R:R:T1169	10.3455	6.02	No	No	4	8	8
14	R:R:L945	R:R:Y1174	16.0517	7.03	No	No	0	8	9
15	R:R:D946	R:R:W950	99.7889	8.93	No	No	0	4	7
16	R:R:L996	R:R:W950	100	3.42	No	No	0	9	7
17	R:R:I953	R:R:L996	48.9955	2.85	No	No	0	9	9
18	R:R:I953	R:R:L957	48.8119	2.85	No	No	0	9	9
19	R:R:E992	R:R:L957	98.3467	7.95	No	No	0	9	9
20	R:R:E992	R:R:S956	97.5846	8.62	No	No	0	9	9
21	R:R:L960	R:R:S956	96.8147	3	Yes	No	0	9	9
22	R:R:C963	R:R:L960	92.5193	3.17	Yes	Yes	1	7	9
23	R:R:C963	R:R:F967	84.7495	6.98	Yes	Yes	1	7	9
24	R:R:F967	R:R:H981	69.4677	11.31	Yes	Yes	1	9	9
25	R:R:H981	R:R:L1153	31.8025	3.86	Yes	Yes	1	9	9
26	R:R:H1191	R:R:L1153	28.8244	10.29	Yes	Yes	1	8	9
27	R:R:F1190	R:R:H1191	22.1957	5.66	Yes	Yes	1	8	8
28	R:R:F1190	R:R:L1194	13.3276	2.44	Yes	No	0	8	9
29	R:R:I1189	R:R:L1194	11.8776	2.85	No	No	0	7	9
30	R:R:I1189	R:R:M1185	10.4198	2.92	No	No	0	7	7
31	R:R:L993	R:R:L996	51.2429	2.77	No	No	0	5	9
32	R:R:L957	R:R:L993	50.3244	2.77	No	No	0	9	5
33	R:R:F967	R:R:T966	16.4543	3.89	Yes	Yes	1	9	9
34	R:R:I980	R:R:W1025	19.3192	7.05	No	Yes	0	9	9
35	R:R:E1029	R:R:I980	21.3203	5.47	No	No	0	9	9
36	R:R:E1029	R:R:H981	19.9562	11.08	No	Yes	1	9	9
37	R:R:H981	R:R:R977	19.2449	4.51	Yes	No	1	9	9
38	R:R:Q1032	R:R:R977	16.8217	4.67	Yes	No	1	8	9
39	R:R:A991	R:R:F1019	27.5737	4.16	No	No	0	8	9
40	R:R:A991	R:R:F1018	26.3386	4.16	No	No	0	8	8
41	R:R:D1085	R:R:R1083	10.283	19.06	No	No	0	8	5
42	R:R:D1085	R:R:T1086	11.7213	7.23	No	No	0	8	8
43	R:R:F1088	R:R:T1086	13.1517	11.67	No	No	0	8	8
44	R:R:F1088	R:R:S1073	18.7954	6.61	No	No	0	8	9
45	R:R:L1082	R:R:S1073	26.7725	3	No	No	0	8	9
46	R:R:L1082	R:R:W1081	24.486	4.56	No	Yes	3	8	6
47	R:R:F1017	R:R:F1018	22.5866	5.36	Yes	No	0	8	8
48	R:R:F1017	R:R:P1059	14.8714	7.22	Yes	Yes	0	8	9
49	R:R:F1023	R:R:W1158	25.6625	4.01	No	Yes	0	9	8
50	R:R:F1023	R:R:I1099	23.2862	2.51	No	No	0	9	5
51	R:R:F1027	R:R:I1099	18.4398	3.77	No	No	0	9	5
52	R:R:F1027	R:R:V1031	12.202	5.24	No	No	0	9	9
53	R:R:F1106	R:R:V1031	11.0959	3.93	No	No	0	6	9
54	R:R:F1106	R:R:G1030	10.0094	3.01	No	No	0	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WYB_nogp

PDB Summary
PDB	7WYB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	244
Number of Links	266
Number of Hubs	30
Number of Links mediated by Hubs	111
Number of Communities	5
Number of Nodes involved in Communities	40
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	40745
Length Of Smallest Path	3
Average Path Length	17.0646
Length of Longest Path	35
Minimum Path Strength	1.33
Average Path Strength	5.28109
Maximum Path Strength	16.29
Minimum Path Correlation	0.71
Average Path Correlation	0.920872
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	41.1958
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.8745
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • ion binding • binding • calcium ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • molecular condensate scaffold activity • protein-macromolecule adaptor activity • molecular adaptor activity • cell adhesion molecule binding • protein binding • cell adhesion mediator activity • carbohydrate binding • developmental process • multicellular organismal process • nervous system development • excitatory synapse assembly • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • cellular process • synapse organization • cellular component organization or biogenesis
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • nervous system development • excitatory synapse assembly • cellular component organization • cellular component biogenesis • multicellular organism development • cell junction organization • cellular component assembly • cell junction assembly • anatomical structure development • cellular process • synapse organization • cellular component organization or biogenesis • synapse assembly • system development • positive regulation of nervous system development • regulation of cellular process • positive regulation of cellular component organization • regulation of cellular component organization • regulation of developmental process • positive regulation of biological process • regulation of nervous system development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of synapse structure or activity • regulation of synapse assembly • regulation of biological quality • positive regulation of cellular process • regulation of multicellular organismal development • regulation of biological process • positive regulation of cellular component biogenesis • biological regulation • regulation of cellular component biogenesis • regulation of cell junction assembly • positive regulation of cell junction assembly • regulation of synapse organization • positive regulation of multicellular organismal process • positive regulation of synapse assembly • cellular response to stimulus • response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • Rho-activating G protein-coupled receptor signaling pathway • behavior • locomotory behavior • locomotion involved in locomotory behavior • locomotion • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • response to chemical • response to oxygen-containing compound • response to nitrogen compound • response to cocaine • response to alkaloid • maintenance of synapse structure • postsynapse organization • cellular component maintenance • cell junction maintenance • organelle organization • maintenance of postsynaptic specialization structure • postsynaptic density organization • postsynaptic specialization organization • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • cell-cell junction • anchoring junction • glutamatergic synapse • Schaffer collateral - CA1 synapse
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • cell-cell junction • anchoring junction • glutamatergic synapse • Schaffer collateral - CA1 synapse • axon • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q80TS3
Sequence	>7WYB_nogp_Chain_R T N F A V L M A H V E V K H S D A V H D L L L D V I T W V G I L L S L V C L L I C I F T F C F F R G L Q S D R N T I H K N L C I S L F V A E L L F L I G I N R T D Q P I A C A V F A A L L H F F F L A A F T W M F L E G V Q L Y I M L V E V F E S E H S R R K Y F Y L V G Y G M P A L I V A V S A A V D Y R S Y G T D K V C W L R L D T Y F I W S F I G P A T L I I M L N V I F L G I A L Y K M F H H T W V I G A I A L L C L L G L T W A F G L M Y I N E S T V I M A Y L F T I F N S L Q G M F I F I F H C V L Q K K V R K E Y G K C L R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7SF7	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	2.9	2022-04-27	doi.org/10.1038/s41586-022-04575-7
	7SF7 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-		2.9	2022-04-27	doi.org/10.1038/s41586-022-04575-7
	7WY5	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY5 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY8	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-Gs)/β1/γ2	2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WY8 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.83	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WYB	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	Gi1/β1/γ2	2.97	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7WYB (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.97	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7X10	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-	chim(NtGi1-G12)/β1/γ2	2.93	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	7X10 (No Gprot)	B2	Adhesion	Adhesion	ADGRL3	Mus musculus	-	-		2.93	2022-10-26	doi.org/10.1016/j.molcel.2022.10.009
	8JMT	B2	Adhesion	Adhesion	ADGRL3	Homo sapiens	-	-	-	3.3	2023-09-06	doi.org/10.1038/s41589-023-01389-0

there is no ligand in network 7WYB_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.