psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F148	L:L:Y149	11.35	No	No	0	1	5
2	L:L:F148	R:R:Y277	6.19	No	Yes	0	1	1
3	L:L:Y149	R:R:F181	13.41	No	No	0	5	4
4	L:L:F150	L:L:F154	3.22	Yes	No	0	4	6
5	L:L:F150	R:R:E269	10.49	Yes	Yes	3	4	4
6	L:L:F150	R:R:S278	3.96	Yes	No	0	4	2
7	L:L:F150	R:R:Q283	8.2	Yes	Yes	3	4	3
8	L:L:P151	R:R:H273	4.58	No	No	0	9	3
9	L:L:G152	R:R:Y188	4.35	No	Yes	0	9	3
10	L:L:G152	R:R:N189	3.39	No	No	0	9	4
11	L:L:Q153	L:L:S157	7.22	No	No	0	6	5
12	L:L:Q153	R:R:Y96	3.38	No	No	0	6	6
13	L:L:Q153	R:R:N189	9.24	No	No	0	6	4
14	L:L:F154	R:R:F101	9.65	No	No	0	6	4
15	L:L:F156	R:R:F86	6.43	Yes	Yes	6	9	7
16	L:L:F156	R:R:F89	4.29	Yes	No	6	9	6
17	L:L:F156	R:R:Y93	8.25	Yes	Yes	6	9	6
18	L:L:F156	R:R:T290	5.19	Yes	No	6	9	6
19	L:L:F156	R:R:F294	3.22	Yes	No	6	9	7
20	L:L:S157	R:R:K210	3.06	No	No	0	5	6
21	R:R:L288	R:R:V37	10.43	No	No	0	5	3
22	R:R:H38	R:R:W39	19.04	No	No	0	5	3
23	R:R:P287	R:R:S41	7.13	Yes	No	0	4	5
24	R:R:L42	R:R:V97	5.96	No	No	0	5	5
25	R:R:L47	R:R:V43	4.47	No	No	0	4	5
26	R:R:L295	R:R:L44	9.69	No	No	0	5	5
27	R:R:Y45	R:R:Y93	7.94	Yes	Yes	6	8	6
28	R:R:I94	R:R:Y45	3.63	No	Yes	0	6	8
29	R:R:V97	R:R:Y45	7.57	No	Yes	0	5	8
30	R:R:T290	R:R:Y45	4.99	No	Yes	6	6	8
31	R:R:G291	R:R:Y45	4.35	No	Yes	0	4	8
32	R:R:F49	R:R:I53	12.56	No	No	0	7	6
33	R:R:F49	R:R:L90	8.53	No	Yes	0	7	7
34	R:R:I53	R:R:P54	3.39	No	No	0	6	4
35	R:R:I53	R:R:L87	4.28	No	No	0	6	6
36	R:R:D83	R:R:N56	13.46	No	Yes	1	9	9
37	R:R:F84	R:R:N56	4.83	No	Yes	0	7	9
38	R:R:N56	R:R:P301	6.52	Yes	No	1	9	9
39	R:R:I58	R:R:K310	8.72	No	Yes	0	6	6
40	R:R:V305	R:R:V59	6.41	No	No	0	6	8
41	R:R:I60	R:R:L77	4.28	No	No	0	7	6
42	R:R:F84	R:R:I60	12.56	No	No	0	7	7
43	R:R:F62	R:R:W61	5.01	Yes	No	16	7	4
44	R:R:F65	R:R:W61	16.04	No	No	0	4	4
45	R:R:K66	R:R:W61	3.48	No	No	16	5	4
46	R:R:F62	R:R:K66	11.17	Yes	No	16	7	5
47	R:R:F62	R:R:W67	9.02	Yes	No	0	7	6
48	R:R:F62	R:R:K310	9.93	Yes	Yes	0	7	6
49	R:R:G64	R:R:T63	3.64	No	No	0	3	7
50	R:R:T63	R:R:T73	3.14	No	No	0	7	8
51	R:R:K309	R:R:W67	4.64	No	No	0	6	6
52	R:R:W67	V:V:L68	3.42	No	No	0	6	7
53	R:R:K68	V:V:T136	10.51	No	No	0	7	4
54	R:R:K69	R:R:L74	5.64	No	No	0	7	6
55	R:R:T70	R:R:T72	3.14	No	No	0	7	7
56	R:R:T70	R:R:T73	4.71	No	No	0	7	8
57	R:R:T70	V:V:E66	12.7	No	No	0	7	7
58	R:R:V71	R:R:W75	7.36	No	Yes	0	6	7
59	R:R:S154	R:R:V71	3.23	Yes	No	0	7	6
60	R:R:L74	R:R:S154	4.5	No	Yes	0	6	7
61	R:R:V130	R:R:W75	6.13	No	Yes	0	6	7
62	R:R:I131	R:R:W75	3.52	No	Yes	0	8	7
63	R:R:D134	R:R:W75	6.7	No	Yes	0	8	7
64	R:R:V157	R:R:W75	3.68	No	Yes	0	6	7
65	R:R:I158	R:R:W75	5.87	No	Yes	0	7	7
66	R:R:F76	R:R:V305	6.55	No	No	0	8	6
67	R:R:F76	V:V:V70	5.24	No	No	0	8	9
68	R:R:I81	R:R:L77	4.28	No	No	0	5	6
69	R:R:F127	R:R:N78	14.5	No	No	17	7	9
70	R:R:I158	R:R:N78	14.16	No	No	0	7	9
71	R:R:N78	R:R:W162	5.65	No	No	17	9	9
72	R:R:D83	R:R:P301	6.44	No	No	1	9	9
73	R:R:I85	R:R:N120	8.5	No	No	0	6	8
74	R:R:F86	R:R:L87	3.65	Yes	No	0	7	6
75	R:R:F86	R:R:N120	6.04	Yes	No	0	7	8
76	R:R:F294	R:R:F86	15	No	Yes	6	7	7
77	R:R:F86	R:R:S297	6.61	Yes	No	0	7	8
78	R:R:L87	R:R:L90	4.15	No	Yes	0	6	7
79	R:R:F89	R:R:Y93	6.19	No	Yes	6	6	6
80	R:R:A117	R:R:F89	8.32	No	No	0	6	6
81	R:R:L90	R:R:P91	3.28	Yes	No	0	7	9
82	R:R:L90	R:R:Y93	3.52	Yes	Yes	0	7	6
83	R:R:F294	R:R:L90	12.18	No	Yes	0	7	7
84	R:R:L92	R:R:W103	3.42	No	Yes	9	6	9
85	R:R:F105	R:R:L92	6.09	Yes	No	9	7	6
86	R:R:L92	R:R:N113	4.12	No	No	0	6	5
87	R:R:Y93	R:R:Y96	4.96	Yes	No	0	6	6
88	R:R:T290	R:R:Y93	4.99	No	Yes	6	6	6
89	R:R:P104	R:R:S95	3.56	No	No	0	3	4
90	R:R:W103	R:R:Y96	60.77	Yes	No	0	9	6
91	R:R:H102	R:R:N100	21.68	Yes	Yes	18	5	3
92	R:R:N100	R:R:N182	4.09	Yes	No	0	3	3
93	R:R:H184	R:R:N100	5.1	No	Yes	18	3	3
94	R:R:F101	R:R:H102	6.79	No	Yes	0	4	5
95	R:R:H102	R:R:H184	19.11	Yes	No	18	5	3
96	R:R:H102	R:R:L186	23.14	Yes	No	0	5	3
97	R:R:F105	R:R:W103	25.05	Yes	Yes	9	7	9
98	R:R:C187	R:R:W103	15.67	No	Yes	9	9	9
99	R:R:H184	R:R:P104	9.15	No	No	0	3	3
100	R:R:F105	R:R:W108	6.01	Yes	No	0	7	1
101	R:R:C110	R:R:F105	4.19	Yes	Yes	9	9	7
102	R:R:C110	R:R:N113	4.72	Yes	No	0	9	5
103	R:R:C110	R:R:R176	6.96	Yes	Yes	9	9	4
104	R:R:C110	R:R:C187	7.28	Yes	No	9	9	9
105	R:R:K111	R:R:R176	13.61	No	Yes	0	7	4
106	R:R:F115	R:R:T116	3.89	No	No	0	6	5
107	R:R:F115	R:R:L119	3.65	No	No	0	6	5
108	R:R:N120	R:R:T116	4.39	No	No	0	8	5
109	R:R:F122	R:R:Q118	8.2	Yes	No	0	6	5
110	R:R:G169	R:R:Q118	3.29	No	No	0	7	5
111	R:R:A165	R:R:L119	3.15	No	No	0	8	5
112	R:R:F122	R:R:M121	4.98	Yes	No	0	6	7
113	R:R:M121	R:R:W259	4.65	No	Yes	0	7	8
114	R:R:F122	R:R:F126	4.29	Yes	Yes	10	6	5
115	R:R:F122	R:R:I168	5.02	Yes	No	10	6	5
116	R:R:F122	R:R:K210	7.44	Yes	No	0	6	6
117	R:R:F122	R:R:I213	3.77	Yes	Yes	10	6	4
118	R:R:A123	R:R:W162	3.89	No	No	0	6	9
119	R:R:P218	R:R:V125	3.53	No	No	0	9	7
120	R:R:V125	R:R:W259	3.68	No	Yes	0	7	8
121	R:R:F126	R:R:L164	4.87	Yes	No	0	5	4
122	R:R:F126	R:R:I213	3.77	Yes	Yes	10	5	4
123	R:R:F126	R:R:F217	8.57	Yes	No	0	5	6
124	R:R:F127	R:R:I161	7.54	No	No	0	7	7
125	R:R:F127	R:R:W162	7.02	No	No	17	7	9
126	R:R:L128	R:R:M222	4.24	No	No	0	9	8
127	R:R:L128	R:R:N300	5.49	No	Yes	1	9	9
128	R:R:L128	R:R:Y304	3.52	No	Yes	1	9	9
129	R:R:F217	R:R:T129	5.19	No	No	0	6	7
130	R:R:T129	R:R:T221	6.28	No	No	0	7	6
131	R:R:I161	R:R:V130	3.07	No	No	0	7	6
132	R:R:I131	R:R:Y304	3.63	No	Yes	0	8	9
133	R:R:S132	R:R:Y226	12.72	No	Yes	0	9	9
134	R:R:D134	R:R:H138	6.3	No	Yes	0	8	8
135	R:R:H135	R:R:Y226	6.53	Yes	Yes	1	9	9
136	R:R:H135	R:R:H244	9.55	Yes	Yes	1	9	7
137	R:R:H135	V:V:L71	14.14	Yes	No	1	9	7
138	R:R:H135	V:V:L73	3.86	Yes	No	1	9	8
139	R:R:C225	R:R:Y136	9.41	No	No	0	6	7
140	R:R:I137	R:R:S145	4.64	No	No	19	5	6
141	R:R:H146	R:R:I137	6.63	No	No	19	5	5
142	R:R:H138	R:R:H141	9.55	Yes	No	0	8	6
143	R:R:H138	V:V:V70	4.15	Yes	No	0	8	9
144	R:R:I140	R:R:L139	4.28	Yes	No	0	7	8
145	R:R:L139	R:R:L229	4.15	No	No	0	8	7
146	R:R:I140	R:R:V143	3.07	Yes	No	0	7	5
147	R:R:I140	R:R:I238	4.42	Yes	No	0	7	4
148	R:R:I140	V:V:N245	14.16	Yes	No	0	7	8
149	R:R:H141	V:V:R65	7.9	No	Yes	0	6	7
150	R:R:P142	V:V:I241	8.47	No	Yes	7	8	8
151	R:R:P142	V:V:Y249	9.74	No	Yes	7	8	7
152	R:R:V143	V:V:Y249	5.05	No	Yes	0	5	7
153	R:R:L144	R:R:R147	3.64	No	No	0	5	5
154	R:R:L144	R:R:R149	7.29	No	No	0	5	7
155	R:R:H146	R:R:S145	6.97	No	No	19	5	6
156	R:R:H146	R:R:H148	19.11	No	No	0	5	3
157	R:R:H148	R:R:N153	3.83	No	No	0	3	4
158	R:R:H148	R:R:V157	4.15	No	No	0	3	6
159	R:R:R149	V:V:R65	12.79	No	Yes	0	7	7
160	R:R:N153	R:R:T150	8.77	No	No	0	4	6
161	R:R:L151	V:V:E134	3.98	No	No	0	3	4
162	R:R:I168	R:R:I213	4.42	No	Yes	10	5	4
163	R:R:G170	R:R:P171	4.06	No	No	0	4	8
164	R:R:L173	R:R:Y174	4.69	No	No	0	4	5
165	R:R:F175	R:R:R202	9.62	No	No	0	4	1
166	R:R:F175	R:R:L206	3.65	No	No	0	4	5
167	R:R:R176	R:R:T178	6.47	Yes	No	0	4	5
168	R:R:C187	R:R:R176	5.57	No	Yes	9	9	4
169	R:R:D177	R:R:Y188	3.45	No	Yes	15	5	3
170	R:R:D177	R:R:N190	4.04	No	No	15	5	3
171	R:R:T178	R:R:T185	4.71	No	No	0	5	4
172	R:R:V179	R:R:Y188	10.09	No	Yes	0	1	3
173	R:R:F181	R:R:N182	3.62	No	No	0	4	3
174	R:R:N190	R:R:Y188	11.63	No	Yes	15	3	3
175	R:R:H204	R:R:I201	3.98	No	No	0	4	1
176	R:R:H203	R:R:T207	8.21	No	No	3	4	5
177	R:R:H203	R:R:L270	11.57	No	Yes	3	4	5
178	R:R:L270	R:R:T207	14.74	Yes	No	3	5	5
179	R:R:I213	R:R:V209	3.07	Yes	No	0	4	2
180	R:R:K210	R:R:Y262	4.78	No	Yes	0	6	6
181	R:R:F211	R:R:Y215	6.19	No	No	0	6	8
182	R:R:F211	R:R:H263	10.18	No	No	0	6	8
183	R:R:F211	R:R:I267	11.3	No	No	0	6	5
184	R:R:I212	R:R:L216	5.71	No	No	0	5	4
185	R:R:G214	R:R:P218	4.06	No	No	0	5	9
186	R:R:G214	R:R:H263	3.18	No	No	0	5	8
187	R:R:L219	R:R:Y215	9.38	No	No	0	6	8
188	R:R:L220	R:R:Y215	11.72	No	No	0	4	8
189	R:R:F255	R:R:P218	5.78	Yes	No	0	9	9
190	R:R:F255	R:R:L219	3.65	Yes	No	0	9	6
191	R:R:M222	R:R:Y226	5.99	No	Yes	0	8	9
192	R:R:F255	R:R:M222	14.93	Yes	No	0	9	8
193	R:R:C225	R:R:I224	3.27	No	No	0	6	4
194	R:R:I248	R:R:Y226	6.04	No	Yes	0	7	9
195	R:R:V252	R:R:Y226	3.79	No	Yes	0	7	9
196	R:R:Y226	V:V:L71	3.52	Yes	No	1	9	7
197	R:R:L227	R:R:V252	4.47	No	No	0	3	7
198	R:R:C228	R:R:V233	6.83	No	No	0	4	8
199	R:R:C228	R:R:K234	3.23	No	No	0	4	5
200	R:R:F231	R:R:I230	10.05	No	Yes	11	3	4
201	R:R:F245	R:R:I230	8.79	Yes	Yes	11	6	4
202	R:R:I230	R:R:I248	4.42	Yes	No	0	4	7
203	R:R:I230	R:R:L249	4.28	Yes	No	11	4	4
204	R:R:F231	R:R:F245	3.22	No	Yes	11	3	6
205	R:R:F231	R:R:L249	3.65	No	No	11	3	4
206	R:R:K232	R:R:R236	9.9	No	No	0	5	5
207	R:R:I238	V:V:F244	16.33	No	No	0	4	8
208	R:R:H244	R:R:I240	9.28	Yes	No	0	7	5
209	R:R:H244	R:R:I248	7.95	Yes	No	0	7	7
210	R:R:H244	V:V:L73	7.71	Yes	No	1	7	8
211	R:R:F245	R:R:W246	4.01	Yes	No	0	6	6
212	R:R:F245	R:R:L249	4.87	Yes	No	11	6	4
213	R:R:L303	R:R:V251	4.47	No	No	0	8	7
214	R:R:V251	R:R:Y304	5.05	No	Yes	0	7	9
215	R:R:F255	R:R:W259	9.02	Yes	Yes	0	9	8
216	R:R:T260	R:R:V256	4.76	No	No	0	5	5
217	R:R:C258	R:R:L292	7.94	No	No	0	7	7
218	R:R:C258	R:R:N296	7.87	No	No	0	7	9
219	R:R:W259	R:R:Y262	5.79	Yes	Yes	0	8	6
220	R:R:A293	R:R:W259	5.19	No	Yes	0	8	8
221	R:R:N296	R:R:W259	6.78	No	Yes	0	9	8
222	R:R:P261	R:R:T260	3.5	No	No	0	9	5
223	R:R:H263	R:R:Y262	5.44	No	Yes	0	8	6
224	R:R:F265	R:R:Y262	10.32	Yes	Yes	3	4	6
225	R:R:S289	R:R:Y262	6.36	No	Yes	3	7	6
226	R:R:E269	R:R:F265	9.33	Yes	Yes	3	4	4
227	R:R:F265	R:R:I286	6.28	Yes	No	0	4	4
228	R:R:F265	R:R:S289	5.28	Yes	No	3	4	7
229	R:R:E269	R:R:S266	5.75	Yes	No	0	4	5
230	R:R:E269	R:R:L270	3.98	Yes	Yes	3	4	5
231	R:R:E269	R:R:Q283	7.65	Yes	Yes	3	4	3
232	R:R:I272	R:R:V281	4.61	No	No	0	2	1
233	R:R:I272	R:R:Q283	4.12	No	Yes	0	2	3
234	R:R:H279	R:R:Y277	4.36	No	Yes	14	1	1
235	R:R:H280	R:R:Y277	16.33	No	Yes	14	3	1
236	R:R:H279	R:R:H280	23.88	No	No	14	1	3
237	R:R:I286	R:R:Q283	5.49	No	Yes	0	4	3
238	R:R:N296	R:R:N300	4.09	No	Yes	0	9	9
239	R:R:N300	R:R:Y304	15.12	Yes	Yes	1	9	9
240	R:R:I302	R:R:L306	7.14	No	No	0	6	6
241	R:R:Y304	V:V:L71	4.69	Yes	No	1	9	7
242	R:R:K310	R:R:L306	7.05	Yes	No	0	6	6
243	R:R:I307	R:R:S308	3.1	No	No	0	6	8
244	R:R:S308	V:V:D69	8.83	No	No	0	8	9
245	R:R:K309	V:V:D67	6.91	No	No	0	6	9
246	R:R:K310	R:R:R314	4.95	Yes	Yes	0	6	6
247	R:R:F311	R:R:R314	7.48	No	Yes	0	8	6
248	R:R:Q312	R:R:R316	5.84	No	No	0	8	6
249	R:R:R316	V:V:H159	9.03	No	No	0	6	5
250	R:R:R316	V:V:K160	8.66	No	No	0	6	8
251	R:R:?1359	R:R:C1358	3.91	No	No	0	4	5
252	R:R:?1359	R:R:?1360	21.46	No	Yes	0	4	6
253	R:R:?1360	V:V:K11	12.74	Yes	Yes	0	6	9
254	R:R:?1360	V:V:R25	13.97	Yes	No	0	6	9
255	R:R:?1360	V:V:K294	3.47	Yes	No	0	6	9
256	R:R:?1362	R:R:A1361	4.02	No	No	0	4	7
257	R:R:?1362	R:R:?1363	17.02	No	Yes	5	4	7
258	R:R:?1362	V:V:R7	10.33	No	Yes	5	4	4
259	R:R:?1363	R:R:?1364	25.02	Yes	Yes	5	7	5
260	R:R:?1363	V:V:R7	8.26	Yes	Yes	5	7	4
261	R:R:?1363	V:V:V8	6.33	Yes	No	0	7	7
262	R:R:?1363	V:V:K10	4.8	Yes	No	5	7	9
263	R:R:?1363	V:V:Y21	8.97	Yes	Yes	5	7	8
264	R:R:?1363	V:V:K107	4.8	Yes	Yes	5	7	9
265	R:R:?1364	R:R:L1365	5.89	Yes	No	0	5	5
266	R:R:?1364	V:V:R7	10.33	Yes	Yes	5	5	4
267	R:R:?1364	V:V:K107	6	Yes	Yes	5	5	9
268	R:R:L1365	V:V:V8	4.47	No	No	0	5	7
269	R:R:L1365	V:V:R103	12.15	No	No	0	5	6
270	V:V:R7	V:V:T6	3.88	Yes	No	0	4	4
271	V:V:K10	V:V:Y21	11.94	No	Yes	5	9	8
272	V:V:K11	V:V:V164	4.55	Yes	No	0	9	8
273	V:V:K11	V:V:R165	3.71	Yes	No	0	9	5
274	V:V:K11	V:V:L166	11.28	Yes	No	0	9	8
275	V:V:A12	V:V:T19	3.36	No	No	0	5	7
276	V:V:P14	V:V:S13	3.56	No	No	0	6	8
277	V:V:N15	V:V:S13	4.47	No	No	0	8	8
278	V:V:S13	V:V:V164	3.23	No	No	0	8	8
279	V:V:P14	V:V:R161	11.53	No	No	0	6	7
280	V:V:K17	V:V:N15	11.19	Yes	No	0	5	8
281	V:V:N15	V:V:N162	5.45	No	No	0	8	8
282	V:V:D44	V:V:K17	12.44	No	Yes	20	8	5
283	V:V:K17	V:V:Y47	15.53	Yes	Yes	20	5	5
284	V:V:V164	V:V:V20	6.41	No	No	0	8	6
285	V:V:L104	V:V:Y21	3.52	No	Yes	0	9	8
286	V:V:K107	V:V:Y21	4.78	Yes	Yes	5	9	8
287	V:V:L108	V:V:Y21	10.55	Yes	Yes	5	8	8
288	V:V:L166	V:V:L22	4.15	No	No	0	8	8
289	V:V:G23	V:V:L100	5.13	No	No	0	8	5
290	V:V:E359	V:V:K24	5.4	No	No	0	1	7
291	V:V:L166	V:V:R25	3.64	No	No	0	8	9
292	V:V:L293	V:V:R25	8.5	Yes	No	0	8	9
293	V:V:D26	V:V:V171	8.76	Yes	No	2	9	6
294	V:V:D26	V:V:Y173	4.6	Yes	Yes	2	9	4
295	V:V:D26	V:V:P360	6.44	Yes	Yes	2	9	1
296	V:V:D26	V:V:H362	8.82	Yes	Yes	2	9	1
297	V:V:F27	V:V:V37	10.49	No	No	0	8	8
298	V:V:F27	V:V:I168	7.54	No	No	0	8	8
299	V:V:H30	V:V:V28	4.15	No	No	2	6	8
300	V:V:D35	V:V:V28	4.38	No	No	2	6	8
301	V:V:V28	V:V:Y173	6.31	No	Yes	2	8	4
302	V:V:D29	V:V:V34	5.84	No	No	0	9	7
303	V:V:D29	V:V:K170	12.44	No	No	0	9	9
304	V:V:D29	V:V:Q172	10.44	No	No	0	9	9
305	V:V:D35	V:V:H30	6.3	No	No	2	6	6
306	V:V:I119	V:V:V34	4.61	No	No	0	5	7
307	V:V:E118	V:V:P36	6.29	No	No	0	4	5
308	V:V:F117	V:V:V37	6.55	Yes	No	0	8	8
309	V:V:D38	V:V:G39	3.35	No	No	0	7	8
310	V:V:D38	V:V:L100	8.14	No	No	0	7	5
311	V:V:D38	V:V:Q101	3.92	No	Yes	0	7	9
312	V:V:L104	V:V:V40	5.96	No	No	0	9	8
313	V:V:F115	V:V:V41	5.24	No	Yes	0	9	5
314	V:V:L108	V:V:L42	5.54	Yes	No	0	8	5
315	V:V:L48	V:V:V43	5.96	No	No	0	4	6
316	V:V:D44	V:V:E46	11.69	No	No	0	8	3
317	V:V:D44	V:V:Y47	5.75	No	Yes	20	8	5
318	V:V:E46	V:V:P45	4.72	No	No	0	3	4
319	V:V:H111	V:V:P45	9.15	No	No	0	6	4
320	V:V:V150	V:V:Y47	7.57	No	Yes	0	5	5
321	V:V:N162	V:V:Y47	3.49	No	Yes	0	8	5
322	V:V:F87	V:V:L48	12.18	No	No	0	4	4
323	V:V:E152	V:V:R51	5.82	No	No	0	4	6
324	V:V:R52	V:V:Y54	11.32	No	Yes	22	6	4
325	V:V:Q85	V:V:R52	10.51	No	No	22	9	6
326	V:V:Q85	V:V:Y54	12.4	No	Yes	22	9	4
327	V:V:F149	V:V:Y54	5.16	Yes	Yes	0	5	4
328	V:V:L154	V:V:Y54	9.38	No	Yes	0	3	4
329	V:V:V55	V:V:V84	3.21	Yes	No	12	8	3
330	V:V:F115	V:V:V55	19.66	No	Yes	0	9	8
331	V:V:F117	V:V:V55	5.24	Yes	Yes	12	8	8
332	V:V:N83	V:V:T56	5.85	No	No	0	5	7
333	V:V:F149	V:V:T56	3.89	Yes	No	0	5	7
334	V:V:F117	V:V:L57	8.53	Yes	No	0	8	7
335	V:V:T58	V:V:V81	3.17	No	No	0	7	4
336	V:V:A59	V:V:Y144	8.01	No	No	0	8	7
337	V:V:A60	V:V:R62	6.91	No	Yes	0	8	8
338	V:V:F61	V:V:Y63	4.13	Yes	No	7	9	9
339	V:V:F61	V:V:L79	4.87	Yes	No	0	9	8
340	V:V:F61	V:V:I241	5.02	Yes	Yes	7	9	8
341	V:V:F61	V:V:L243	4.87	Yes	Yes	7	9	7
342	V:V:F61	V:V:G316	4.52	Yes	No	0	9	8
343	V:V:F61	V:V:I317	3.77	Yes	No	7	9	8
344	V:V:R62	V:V:R76	15.99	Yes	No	0	8	8
345	V:V:K138	V:V:R62	7.43	No	Yes	0	8	8
346	V:V:D143	V:V:R62	3.57	No	Yes	0	7	8
347	V:V:F75	V:V:Y63	16.5	No	No	0	9	9
348	V:V:L243	V:V:Y63	8.21	Yes	No	7	7	9
349	V:V:F75	V:V:G64	10.54	No	No	0	9	9
350	V:V:D135	V:V:R65	7.15	No	Yes	0	8	7
351	V:V:R285	V:V:R65	3.2	No	Yes	0	7	7
352	V:V:E66	V:V:T136	8.47	No	No	0	7	4
353	V:V:D67	V:V:G137	3.35	No	No	0	9	8
354	V:V:D69	V:V:T74	8.67	No	No	0	9	6
355	V:V:F75	V:V:L73	10.96	No	No	0	9	8
356	V:V:R76	V:V:T74	3.88	No	No	0	8	6
357	V:V:D78	V:V:R76	4.76	No	No	0	8	8
358	V:V:K77	V:V:L243	5.64	No	Yes	0	9	7
359	V:V:D78	V:V:V81	4.38	No	No	0	8	4
360	V:V:L79	V:V:P124	3.28	No	Yes	0	8	9
361	V:V:L315	V:V:L79	4.15	No	No	0	5	8
362	V:V:F80	V:V:P120	13	No	Yes	0	4	7
363	V:V:F117	V:V:V84	3.93	Yes	No	12	8	3
364	V:V:P88	V:V:Q85	3.16	No	No	0	9	9
365	V:V:F87	V:V:Y113	15.47	No	No	0	4	3
366	V:V:K95	V:V:P96	3.35	No	No	0	3	3
367	V:V:L97	V:V:Q101	5.32	Yes	Yes	21	4	9
368	V:V:E102	V:V:L97	10.6	No	Yes	0	6	4
369	V:V:L97	V:V:P114	6.57	Yes	No	21	4	8
370	V:V:Q101	V:V:T98	4.25	Yes	No	0	9	8
371	V:V:E102	V:V:R99	3.49	No	No	0	6	4
372	V:V:R103	V:V:R99	3.2	No	No	0	6	4
373	V:V:P114	V:V:Q101	4.74	No	Yes	21	8	9
374	V:V:Q101	V:V:T116	5.67	Yes	No	0	9	4
375	V:V:I105	V:V:P114	5.08	No	No	0	4	8
376	V:V:K107	V:V:L108	7.05	Yes	Yes	5	9	8
377	V:V:A112	V:V:L108	3.15	No	Yes	0	8	8
378	V:V:E110	V:V:H111	9.85	No	No	0	3	6
379	V:V:I119	V:V:P120	3.39	No	Yes	0	5	7
380	V:V:L123	V:V:P120	4.93	No	Yes	0	6	7
381	V:V:N122	V:V:N311	14.98	No	Yes	0	5	4
382	V:V:L123	V:V:P124	4.93	No	Yes	0	6	9
383	V:V:L123	V:V:Y144	3.52	No	No	0	6	7
384	V:V:P124	V:V:V142	3.53	Yes	No	0	9	9
385	V:V:G316	V:V:P124	4.06	No	Yes	0	8	9
386	V:V:Q172	V:V:S125	4.33	No	No	0	9	7
387	V:V:S125	V:V:T304	3.2	No	No	0	7	9
388	V:V:G291	V:V:S126	3.71	No	No	0	9	9
389	V:V:A301	V:V:V127	3.39	No	No	0	9	8
390	V:V:I140	V:V:L129	7.14	No	No	0	9	8
391	V:V:P131	V:V:Q130	3.16	No	No	0	8	9
392	V:V:L287	V:V:Q130	7.99	Yes	No	0	7	9
393	V:V:L289	V:V:Q130	5.32	No	No	0	9	9
394	V:V:G132	V:V:P133	4.06	No	No	0	6	4
395	V:V:E134	V:V:P133	4.72	No	No	0	4	4
396	V:V:D135	V:V:I140	4.2	No	No	0	8	9
397	V:V:K170	V:V:Y144	10.75	No	No	0	9	7
398	V:V:I168	V:V:V146	3.07	No	No	0	8	6
399	V:V:K147	V:V:S163	7.65	No	No	0	7	8
400	V:V:F149	V:V:I158	5.02	Yes	No	0	5	5
401	V:V:E152	V:V:N153	6.57	No	No	0	4	4
402	V:V:H159	V:V:R161	6.77	No	No	0	5	7
403	V:V:E169	V:V:V171	5.7	Yes	No	2	9	6
404	V:V:D290	V:V:E169	3.9	No	Yes	0	9	9
405	V:V:E169	V:V:G291	3.27	Yes	No	0	9	9
406	V:V:E169	V:V:L293	3.98	Yes	Yes	2	9	8
407	V:V:E169	V:V:H362	16	Yes	Yes	2	9	1
408	V:V:V171	V:V:Y173	6.31	No	Yes	2	6	4
409	V:V:L305	V:V:Q172	3.99	No	No	0	5	9
410	V:V:P356	V:V:Y173	16.69	No	Yes	0	9	4
411	V:V:A174	V:V:M352	3.22	No	No	0	9	8
412	V:V:E176	V:V:K355	4.05	No	No	0	3	6
413	V:V:G179	V:V:P180	4.06	No	No	0	6	4
414	V:V:E206	V:V:G179	3.27	Yes	No	0	7	6
415	V:V:P182	V:V:Q181	3.16	No	No	0	9	7
416	V:V:Q181	V:V:S202	5.78	No	No	0	7	7
417	V:V:L203	V:V:P182	4.93	Yes	No	0	8	9
418	V:V:E206	V:V:P182	4.72	Yes	No	0	7	9
419	V:V:A184	V:V:V345	3.39	No	No	0	5	7
420	V:V:A184	V:V:L347	3.15	No	No	0	5	6
421	V:V:E185	V:V:E200	19.03	No	No	0	5	7
422	V:V:T186	V:V:V343	4.76	No	No	0	7	7
423	V:V:T186	V:V:V345	4.76	No	No	0	7	7
424	V:V:H198	V:V:T187	8.21	No	No	0	6	5
425	V:V:Q189	V:V:T224	7.09	No	No	0	6	9
426	V:V:L197	V:V:T224	4.42	No	No	0	7	9
427	V:V:L199	V:V:L327	6.92	No	No	0	6	7
428	V:V:L199	V:V:V343	4.47	No	No	0	6	7
429	V:V:E200	V:V:H219	8.62	No	No	0	7	5
430	V:V:A201	V:V:L347	3.15	No	No	0	7	6
431	V:V:L203	V:V:Y208	8.21	Yes	Yes	8	8	6
432	V:V:L203	V:V:V323	4.47	Yes	No	0	8	7
433	V:V:L203	V:V:L347	4.15	Yes	No	0	8	6
434	V:V:F349	V:V:L203	3.65	Yes	Yes	8	7	8
435	V:V:D204	V:V:S215	5.89	No	No	0	6	4
436	V:V:K205	V:V:Y208	9.55	No	Yes	0	8	6
437	V:V:E206	V:V:F349	3.5	Yes	Yes	0	7	7
438	V:V:E206	V:V:T350	5.64	Yes	No	0	7	4
439	V:V:I207	V:V:Y209	4.84	No	No	0	5	6
440	V:V:I214	V:V:Y208	15.71	No	Yes	8	8	6
441	V:V:F349	V:V:Y208	6.19	Yes	Yes	8	7	6
442	V:V:E212	V:V:Y209	13.47	No	No	0	8	6
443	V:V:P354	V:V:Y209	11.13	No	No	0	8	6
444	V:V:H210	V:V:N299	14.03	Yes	No	24	9	8
445	V:V:H210	V:V:S302	5.58	Yes	No	0	9	9
446	V:V:H210	V:V:L351	9	Yes	No	0	9	8
447	V:V:H210	V:V:H353	15.53	Yes	No	24	9	8
448	V:V:E212	V:V:P213	3.14	No	No	0	8	4
449	V:V:I214	V:V:P276	5.08	No	No	0	8	9
450	V:V:F349	V:V:I214	3.77	Yes	No	8	7	8
451	V:V:I233	V:V:V216	3.07	Yes	No	0	5	7
452	V:V:V216	V:V:V323	3.21	No	No	0	7	7
453	V:V:H219	V:V:N217	19.13	No	No	0	5	6
454	V:V:T221	V:V:T267	3.14	No	No	0	5	6
455	V:V:N222	V:V:V262	8.87	No	No	0	9	7
456	V:V:K226	V:V:V329	7.59	No	No	0	8	6
457	V:V:P264	V:V:T227	10.49	No	No	0	5	5
458	V:V:K229	V:V:K230	7.18	No	No	25	8	5
459	V:V:D259	V:V:K229	9.68	No	No	25	3	8
460	V:V:D259	V:V:K230	8.3	No	No	25	3	5
461	V:V:K232	V:V:S234	4.59	No	No	0	6	5
462	V:V:K232	V:V:M255	5.76	No	No	0	6	3
463	V:V:I233	V:V:Y272	3.63	Yes	Yes	0	5	4
464	V:V:I233	V:V:L274	4.28	Yes	No	0	5	5
465	V:V:I233	V:V:V325	6.14	Yes	No	0	5	8
466	V:V:R236	V:V:S234	3.95	Yes	No	4	5	5
467	V:V:K324	V:V:S234	3.06	No	No	4	6	5
468	V:V:V235	V:V:V253	3.21	No	Yes	0	8	9
469	V:V:A254	V:V:V235	3.39	No	No	0	7	8
470	V:V:V235	V:V:V323	3.21	No	No	0	8	7
471	V:V:R236	V:V:Y238	7.2	Yes	Yes	4	5	4
472	V:V:K324	V:V:R236	17.33	No	Yes	4	6	5
473	V:V:E346	V:V:R236	10.47	No	Yes	4	8	5
474	V:V:L287	V:V:Q237	5.32	Yes	Yes	0	7	9
475	V:V:A288	V:V:Q237	4.55	No	Yes	0	9	9
476	V:V:Q237	V:V:V319	5.73	Yes	No	8	9	8
477	V:V:Q237	V:V:Y321	15.78	Yes	Yes	8	9	9
478	V:V:D240	V:V:Y238	4.6	Yes	Yes	4	6	4
479	V:V:Q248	V:V:Y238	3.38	No	Yes	4	6	4
480	V:V:K250	V:V:Y238	11.94	No	Yes	4	5	4
481	V:V:K322	V:V:Y238	11.94	No	Yes	4	5	4
482	V:V:E346	V:V:Y238	5.61	No	Yes	4	8	4
483	V:V:D240	V:V:Q248	9.14	Yes	No	4	6	6
484	V:V:D240	V:V:I318	4.2	Yes	No	0	6	5
485	V:V:I241	V:V:Y249	4.84	Yes	Yes	7	8	7
486	V:V:I241	V:V:I317	7.36	Yes	No	7	8	8
487	V:V:F244	V:V:L243	10.96	No	Yes	0	8	7
488	V:V:L243	V:V:L315	4.15	Yes	No	0	7	5
489	V:V:A247	V:V:Y249	6.67	No	Yes	0	8	7
490	V:V:K250	V:V:Q248	4.07	No	No	4	5	6
491	V:V:P252	V:V:V251	3.53	No	No	0	4	6
492	V:V:P276	V:V:V253	3.53	No	Yes	0	9	9
493	V:V:L300	V:V:V253	4.47	Yes	Yes	0	9	9
494	V:V:E256	V:V:Y272	6.73	No	Yes	0	4	4
495	V:V:E256	V:V:L274	5.3	No	No	0	4	5
496	V:V:A258	V:V:Y272	4	No	Yes	0	5	4
497	V:V:D260	V:V:F268	13.14	No	Yes	13	6	5
498	V:V:D260	V:V:Y272	4.6	No	Yes	13	6	4
499	V:V:F268	V:V:V262	3.93	Yes	No	0	5	7
500	V:V:A263	V:V:S266	3.42	No	No	0	4	6
501	V:V:F268	V:V:K270	8.69	Yes	No	13	5	8
502	V:V:F268	V:V:Y272	3.09	Yes	Yes	13	5	4
503	V:V:K270	V:V:Y272	15.53	No	Yes	13	8	4
504	V:V:P276	V:V:T275	3.5	No	No	0	9	4
505	V:V:F277	V:V:N280	13.29	No	No	0	3	4
506	V:V:N280	V:V:N281	10.9	No	No	0	4	9
507	V:V:K284	V:V:N281	9.79	No	No	0	8	9
508	V:V:D297	V:V:R282	5.96	No	No	0	8	6
509	V:V:L287	V:V:L300	4.15	Yes	Yes	0	7	9
510	V:V:K292	V:V:L289	4.23	No	No	0	6	9
511	V:V:D290	V:V:N299	4.04	No	No	0	9	8
512	V:V:D290	V:V:S302	5.89	No	No	0	9	9
513	V:V:K292	V:V:T298	10.51	No	No	0	6	8
514	V:V:H362	V:V:L293	5.14	Yes	Yes	2	1	8
515	V:V:E296	V:V:K294	5.4	No	No	0	7	9
516	V:V:D297	V:V:E364	12.99	No	No	0	8	1
517	V:V:H353	V:V:N299	8.93	No	No	24	8	8
518	V:V:L300	V:V:Y321	3.52	Yes	Yes	0	9	9
519	V:V:A301	V:V:V319	3.39	No	No	0	9	8
520	V:V:S303	V:V:T350	6.4	No	No	0	8	4
521	V:V:I318	V:V:T304	4.56	No	No	0	5	9
522	V:V:L305	V:V:M352	5.65	No	No	0	5	8
523	V:V:L306	V:V:N311	6.87	No	Yes	23	4	4
524	V:V:I314	V:V:L306	8.56	No	No	23	5	4
525	V:V:N311	V:V:R307	4.82	Yes	No	0	4	4
526	V:V:E308	V:V:G309	4.91	No	No	0	3	4
527	V:V:I314	V:V:N311	4.25	No	Yes	23	5	4
528	V:V:E313	V:V:R312	3.49	No	No	0	7	4
529	V:V:E313	V:V:L315	5.3	No	No	0	7	5
530	V:V:I314	V:V:I318	5.89	No	No	0	5	5
531	V:V:V319	V:V:Y321	5.05	No	Yes	8	8	9
532	V:V:F349	V:V:Y321	7.22	Yes	Yes	8	7	9
533	V:V:L351	V:V:Y321	8.21	No	Yes	0	8	9
534	V:V:E346	V:V:K322	6.75	No	No	4	8	5
535	V:V:K322	V:V:P348	8.36	No	No	0	5	9
536	V:V:A344	V:V:K324	3.21	No	No	0	4	6
537	V:V:D342	V:V:K326	19.36	No	No	0	7	7
538	V:V:A344	V:V:K326	4.82	No	No	0	4	7
539	V:V:M352	V:V:T350	6.02	No	No	0	8	4
540	V:V:K355	V:V:P356	3.35	No	No	0	6	9
541	V:V:P356	V:V:P360	7.79	No	Yes	0	9	1
542	V:V:E358	V:V:K357	10.8	No	No	0	1	1
543	V:V:E359	V:V:P360	7.86	No	Yes	0	1	1
544	V:V:H362	V:V:P360	6.1	Yes	Yes	2	1	1
545	V:V:E367	V:V:R363	10.47	No	No	0	1	1
546	V:V:P366	V:V:V365	5.3	No	No	0	1	1
547	V:V:H353	V:V:P354	3.05	No	No	0	8	8
548	R:R:I107	R:R:T178	3.04	No	No	0	4	5
549	R:R:A313	R:R:Q312	3.03	No	No	0	4	8
550	V:V:F115	V:V:G39	3.01	No	No	0	9	8
551	R:R:L151	R:R:S154	3	No	Yes	0	3	7
552	R:R:L155	R:R:S154	3	No	Yes	0	4	7
553	R:R:L220	R:R:S223	3	No	No	0	4	3
554	R:R:L227	R:R:S223	3	No	No	0	3	3
555	R:R:R243	R:R:W246	3	No	No	0	7	6
556	V:V:K10	V:V:T19	3	No	No	0	9	7
557	V:V:K95	V:V:T116	3	No	No	0	3	4
558	V:V:K292	V:V:T128	3	No	No	0	6	6
559	V:V:G132	V:V:R285	3	No	No	0	6	7
560	R:R:L288	R:R:V40	2.98	No	No	0	5	6
561	R:R:L51	R:R:V50	2.98	No	No	0	5	4
562	R:R:L303	R:R:V250	2.98	No	No	0	8	6
563	R:R:N275	R:R:S276	2.98	No	No	0	3	3
564	R:R:L306	R:R:V305	2.98	No	No	0	6	6
565	V:V:L18	V:V:V41	2.98	No	Yes	0	6	5
566	V:V:L18	V:V:V43	2.98	No	No	0	6	6
567	V:V:L293	V:V:V167	2.98	Yes	No	0	8	5
568	V:V:L199	V:V:V220	2.98	No	No	0	6	6
569	V:V:L327	V:V:V228	2.98	No	No	0	7	8
570	V:V:L287	V:V:V251	2.98	Yes	No	0	7	6
571	V:V:N281	V:V:V253	2.96	No	Yes	0	9	9
572	R:R:L303	R:R:T247	2.95	No	No	0	8	7
573	R:R:L264	R:R:T260	2.95	No	No	0	5	5
574	V:V:F87	V:V:P88	2.89	No	No	0	4	9
575	V:V:P178	V:V:R177	2.88	No	No	0	4	3
576	R:R:I159	R:R:L163	2.85	No	No	0	3	4
577	V:V:I31	V:V:L305	2.85	No	No	0	5	5
578	V:V:I119	V:V:L57	2.85	No	No	0	5	7
579	V:V:E145	V:V:V167	2.85	No	No	0	7	5
580	V:V:I231	V:V:L327	2.85	No	No	0	6	7
581	R:R:K152	R:R:L155	2.82	No	No	0	5	4
582	R:R:M99	R:R:N100	2.8	No	Yes	0	4	3
583	V:V:H219	V:V:S269	2.79	No	No	0	5	5
584	R:R:P171	R:R:Y174	2.78	No	No	0	8	5
585	R:R:A284	R:R:F101	2.77	No	No	0	2	4
586	V:V:A82	V:V:F80	2.77	No	No	0	4	4
587	V:V:A151	V:V:F149	2.77	No	Yes	0	6	5
588	V:V:A279	V:V:F277	2.77	No	No	0	4	3
589	V:V:L278	V:V:L300	2.77	No	Yes	0	8	9
590	R:R:H138	R:R:T72	2.74	Yes	No	0	8	7
591	V:V:D32	V:V:L33	2.71	No	No	0	4	3
592	V:V:E257	V:V:K232	2.7	No	No	0	6	6
593	V:V:E283	V:V:K284	2.7	No	No	0	5	8
594	R:R:R314	R:R:S317	2.64	Yes	No	0	6	5
595	V:V:F149	V:V:S163	2.64	Yes	No	0	5	8
596	V:V:E156	V:V:N153	2.63	No	No	0	6	4
597	V:V:R51	V:V:V150	2.62	No	No	0	6	5
598	R:R:H204	R:R:L270	2.57	No	Yes	0	4	5
599	R:R:F311	R:R:I307	2.51	No	No	0	8	6
600	V:V:K294	V:V:R363	2.48	No	No	0	9	1
601	R:R:F160	R:R:L163	2.44	No	No	0	3	4
602	R:R:K234	R:R:Y136	2.39	No	No	0	5	7
603	R:R:L139	R:R:Y136	2.34	No	No	0	8	7
604	R:R:G169	R:R:G170	2.11	No	No	0	7	4
605	R:R:G285	R:R:P287	2.03	No	Yes	0	6	4
606	R:R:C298	R:R:G52	1.96	No	No	0	7	8
607	V:V:P120	V:V:P121	1.95	Yes	No	0	7	4
608	V:V:A310	V:V:G309	1.95	No	No	0	4	4
609	V:V:P360	V:V:P361	1.95	Yes	No	0	1	1
610	V:V:A174	V:V:P175	1.87	No	No	0	9	9
611	V:V:A263	V:V:P264	1.87	No	No	0	4	5
612	V:V:G286	V:V:V251	1.84	No	No	0	9	6
613	R:R:G106	R:R:T185	1.82	No	No	0	7	4
614	R:R:A48	R:R:C298	1.81	No	No	0	6	7
615	R:R:A123	R:R:A82	1.79	No	No	0	6	8
616	R:R:P261	R:R:S289	1.78	No	No	0	9	7
617	R:R:P287	R:R:V37	1.77	Yes	No	0	4	3
618	R:R:P287	R:R:V97	1.77	Yes	No	0	4	5
619	V:V:P361	V:V:V365	1.77	No	No	0	1	1
620	R:R:G55	R:R:I58	1.76	No	No	0	7	6
621	V:V:G141	V:V:I317	1.76	No	No	0	9	8
622	V:V:P36	V:V:T116	1.75	No	No	0	5	4
623	V:V:P213	V:V:T273	1.75	No	No	0	4	3
624	V:V:G16	V:V:K17	1.74	No	Yes	0	5	5
625	L:L:A155	L:L:S157	1.71	No	No	0	9	5
626	R:R:G291	R:R:L44	1.71	No	No	0	4	5
627	R:R:A82	R:R:S124	1.71	No	No	0	8	9
628	R:R:A172	R:R:S114	1.71	No	No	0	4	5
629	R:R:C258	R:R:V257	1.71	No	No	0	7	5
630	V:V:G109	V:V:L108	1.71	No	Yes	0	9	8
631	R:R:G52	R:R:N56	1.7	No	Yes	0	8	9
632	R:R:A80	R:R:V59	1.7	No	No	0	8	8
633	V:V:A148	V:V:V20	1.7	No	No	0	6	6
634	V:V:A148	V:V:V41	1.7	No	Yes	0	6	5
635	V:V:I207	V:V:P178	1.69	No	No	0	5	4
636	V:V:D69	V:V:G72	1.68	No	No	0	9	9
637	V:V:A139	V:V:T128	1.68	No	No	0	5	6
638	R:R:N300	R:R:P301	1.63	Yes	No	1	9	9
639	V:V:S86	V:V:V41	1.62	Yes	Yes	0	6	5
640	V:V:S86	V:V:V53	1.62	Yes	No	0	6	7
641	V:V:S86	V:V:V55	1.62	Yes	Yes	12	6	8
642	V:V:S86	V:V:V84	1.62	Yes	No	12	6	3
643	V:V:S266	V:V:V262	1.62	No	No	0	6	7
644	R:R:A172	R:R:K111	1.61	No	No	0	4	7
645	R:R:A284	R:R:M282	1.61	No	No	0	2	4
646	R:R:V253	R:R:V257	1.6	No	No	0	5	5
647	V:V:S202	V:V:T183	1.6	No	No	0	7	4
648	V:V:V218	V:V:V220	1.6	No	No	0	7	6
649	V:V:V218	V:V:V325	1.6	No	No	0	7	8
650	V:V:V228	V:V:V329	1.6	No	No	0	8	6
651	R:R:C225	R:R:L133	1.59	No	No	0	6	6
652	V:V:T261	V:V:V228	1.59	No	No	0	5	8
653	V:V:T246	V:V:V242	1.59	No	No	0	7	6
654	R:R:A254	R:R:L299	1.58	No	No	0	7	7
655	R:R:I238	R:R:S237	1.55	No	No	0	4	4
656	R:R:I156	R:R:V157	1.54	No	No	0	3	6
657	R:R:I201	R:R:V205	1.54	No	No	0	1	3
658	R:R:I212	R:R:V209	1.54	No	No	0	5	2
659	R:R:I267	R:R:T271	1.52	No	No	0	5	4
660	V:V:K230	V:V:V328	1.52	No	No	0	5	4
661	V:V:K326	V:V:V328	1.52	No	No	0	7	4
662	R:R:L79	R:R:S124	1.5	No	No	0	9	9
663	R:R:L119	R:R:S166	1.5	No	No	0	5	4
664	R:R:L167	R:R:S166	1.5	No	No	0	4	4
665	R:R:K1367	V:V:T6	1.5	No	No	0	5	4
666	V:V:K226	V:V:T224	1.5	No	No	0	8	9
667	R:R:L206	R:R:V209	1.49	No	No	0	5	2
668	R:R:I156	R:R:I159	1.47	No	No	0	3	3
669	V:V:D240	V:V:S320	1.47	Yes	No	0	6	8
670	R:R:I240	R:R:K232	1.45	No	No	0	5	5
671	L:L:F150	L:L:P151	1.44	Yes	No	0	4	9
672	R:R:I302	R:R:L299	1.43	No	No	0	6	7
673	R:R:K111	R:R:L109	1.41	No	No	0	7	5
674	R:R:E180	R:R:T185	1.41	No	No	0	1	4
675	R:R:L239	V:V:K77	1.41	No	No	0	3	9
676	V:V:K94	V:V:L97	1.41	No	Yes	0	3	4
677	V:V:E200	V:V:T183	1.41	No	No	0	7	4
678	R:R:H38	R:R:S41	1.39	No	No	0	5	5
679	R:R:H244	R:R:S241	1.39	Yes	No	0	7	7
680	R:R:L44	R:R:L47	1.38	No	No	0	5	4
681	V:V:H198	V:V:T221	1.37	No	No	0	6	5
682	V:V:A239	V:V:Y249	1.33	No	Yes	0	8	7
683	V:V:E367	V:V:N368	1.31	No	No	0	1	1
684	V:V:R188	V:V:T186	1.29	No	No	0	8	7
685	R:R:S276	R:R:Y277	1.27	No	Yes	0	3	1
686	V:V:S215	V:V:Y208	1.27	No	Yes	0	4	6
687	V:V:E296	V:V:E364	1.27	No	No	0	7	1
688	V:V:E364	V:V:E367	1.27	No	No	0	1	1
689	V:V:D32	V:V:H30	1.26	No	No	0	4	6
690	R:R:H273	R:R:H274	1.19	No	No	0	3	3
691	R:R:I272	R:R:W268	1.17	No	No	0	2	4
692	R:R:F315	R:R:R314	1.07	No	Yes	0	5	6
693	R:R:H204	R:R:W208	1.06	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F150	5.462	5	3	4
2	L:L:F156	5.476	5	6	9
3	R:R:Y45	5.696	5	6	8
4	R:R:N56	6.6275	4	1	9
5	R:R:F62	8.7825	4	16	7
6	R:R:W75	5.54333	6	0	7
7	R:R:F86	7.546	5	6	7
8	R:R:L90	6.332	5	0	7
9	R:R:Y93	5.975	6	6	6
10	R:R:N100	8.4175	4	18	3
11	R:R:H102	17.68	4	18	5
12	R:R:W103	26.2275	4	9	9
13	R:R:F105	10.335	4	9	7
14	R:R:C110	5.7875	4	9	9
15	R:R:F122	5.61667	6	10	6
16	R:R:F126	5.375	4	10	5
17	R:R:H135	8.52	4	1	9
18	R:R:H138	5.685	4	0	8
19	R:R:I140	6.4825	4	0	7
20	R:R:S154	3.4325	4	0	7
21	R:R:R176	8.1525	4	9	4
22	R:R:Y188	7.38	4	15	3
23	R:R:I213	3.7575	4	10	4
24	R:R:Y226	6.43167	6	1	9
25	R:R:I230	6.885	4	11	4
26	R:R:H244	7.176	5	1	7
27	R:R:F245	5.2225	4	11	6
28	R:R:F255	8.345	4	0	9
29	R:R:W259	5.85167	6	0	8
30	R:R:Y262	6.538	5	3	6
31	R:R:F265	7.8025	4	3	4
32	R:R:E269	7.44	5	3	4
33	R:R:L270	8.215	4	3	5
34	R:R:Y277	7.0375	4	14	1
35	R:R:Q283	6.365	4	3	3
36	R:R:P287	3.175	4	0	4
37	R:R:N300	6.5825	4	1	9
38	R:R:Y304	6.402	5	1	9
39	R:R:K310	7.6625	4	0	6
40	R:R:R314	4.035	4	0	6
41	R:R:?1360	12.91	4	0	6
42	R:R:?1363	10.7429	7	5	7
43	R:R:?1364	11.81	4	5	5
44	V:V:R7	8.2	4	5	4
45	V:V:K11	8.07	4	0	9
46	V:V:K17	10.225	4	20	5
47	V:V:Y21	7.952	5	5	8
48	V:V:D26	7.155	4	2	9
49	V:V:V41	2.885	4	0	5
50	V:V:Y47	8.085	4	20	5
51	V:V:Y54	9.565	4	22	4
52	V:V:V55	7.4325	4	12	8
53	V:V:F61	4.53	6	7	9
54	V:V:R62	8.475	4	0	8
55	V:V:R65	7.76	4	0	7
56	V:V:S86	1.62	4	12	6
57	V:V:L97	5.975	4	21	4
58	V:V:Q101	4.78	5	21	9
59	V:V:K107	5.6575	4	5	9
60	V:V:L108	5.6	5	5	8
61	V:V:F117	6.0625	4	12	8
62	V:V:P120	5.8175	4	0	7
63	V:V:P124	3.95	4	0	9
64	V:V:F149	3.896	5	0	5
65	V:V:E169	6.57	5	2	9
66	V:V:Y173	8.4775	4	2	4
67	V:V:L203	5.082	5	8	8
68	V:V:E206	4.2825	4	0	7
69	V:V:Y208	8.186	5	8	6
70	V:V:H210	11.035	4	24	9
71	V:V:I233	4.28	4	0	5
72	V:V:R236	9.7375	4	4	5
73	V:V:Q237	7.845	4	8	9
74	V:V:Y238	7.445	6	4	4
75	V:V:D240	4.8525	4	4	6
76	V:V:I241	6.4225	4	7	8
77	V:V:L243	6.766	5	7	7
78	V:V:Y249	5.526	5	7	7
79	V:V:V253	3.5425	4	0	9
80	V:V:F268	7.2125	4	13	5
81	V:V:Y272	6.26333	6	13	4
82	V:V:L287	5.11	4	0	7
83	V:V:L293	5.15	4	2	8
84	V:V:L300	3.7275	4	0	9
85	V:V:N311	7.73	4	23	4
86	V:V:Y321	7.956	5	8	9
87	V:V:F349	4.866	5	8	7
88	V:V:P360	6.028	5	2	1
89	V:V:H362	9.015	4	2	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E269	R:R:F265	13.4324	9.33	Yes	Yes	3	4	4
2	R:R:F265	R:R:Y262	15.4943	10.32	Yes	Yes	3	4	6
3	R:R:K210	R:R:Y262	24.559	4.78	No	Yes	0	6	6
4	L:L:S157	R:R:K210	24.3071	3.06	No	No	0	5	6
5	L:L:Q153	L:L:S157	23.6411	7.22	No	No	0	6	5
6	L:L:Q153	R:R:Y96	21.2963	3.38	No	No	0	6	6
7	R:R:Y93	R:R:Y96	14.8352	4.96	Yes	No	0	6	6
8	R:R:W259	R:R:Y262	40.3132	5.79	Yes	Yes	0	8	6
9	R:R:I131	R:R:Y304	31.4277	3.63	No	Yes	0	8	9
10	R:R:I131	R:R:W75	31.1057	3.52	No	Yes	0	8	7
11	R:R:D134	R:R:W75	20.2061	6.7	No	Yes	0	8	7
12	R:R:D134	R:R:H138	19.8699	6.3	No	Yes	0	8	8
13	R:R:H138	V:V:V70	13.4223	4.15	Yes	No	0	8	9
14	R:R:F76	V:V:V70	13.0771	5.24	No	No	0	8	9
15	R:R:F76	R:R:V305	12.7314	6.55	No	No	0	8	6
16	R:R:L306	R:R:V305	11.6917	2.98	No	No	0	6	6
17	R:R:K310	R:R:L306	10.2994	7.05	Yes	No	0	6	6
18	R:R:F255	R:R:W259	44.4482	9.02	Yes	Yes	0	9	8
19	R:R:F255	R:R:M222	47.5545	14.93	Yes	No	0	9	8
20	R:R:M222	R:R:Y226	47.931	5.99	No	Yes	0	8	9
21	R:R:H135	R:R:Y226	49.1027	6.53	Yes	Yes	1	9	9
22	R:R:Y304	V:V:L71	34.5285	4.69	Yes	No	1	9	7
23	R:R:H135	V:V:L73	83.5004	3.86	Yes	No	1	9	8
24	V:V:F75	V:V:L73	87.3162	10.96	No	No	0	9	8
25	V:V:F75	V:V:Y63	87.7856	16.5	No	No	0	9	9
26	V:V:F61	V:V:Y63	86.7461	4.13	Yes	No	7	9	9
27	V:V:F61	V:V:L79	48.4821	4.87	Yes	No	0	9	8
28	V:V:L79	V:V:P124	51.4585	3.28	No	Yes	0	8	9
29	V:V:L123	V:V:P124	100	4.93	No	Yes	0	6	9
30	V:V:L123	V:V:P120	67.2736	4.93	No	Yes	0	6	7
31	V:V:I119	V:V:P120	67.2323	3.39	No	Yes	0	5	7
32	V:V:I119	V:V:L57	72.2658	2.85	No	No	0	5	7
33	V:V:F117	V:V:L57	72.1716	8.53	Yes	No	0	8	7
34	V:V:F117	V:V:V55	51.027	5.24	Yes	Yes	12	8	8
35	V:V:F115	V:V:V55	30.3732	19.66	No	Yes	0	9	8
36	V:V:F115	V:V:V41	22.0275	5.24	No	Yes	0	9	5
37	V:V:A148	V:V:V41	53.5669	1.7	No	Yes	0	6	5
38	V:V:A148	V:V:V20	53.167	1.7	No	No	0	6	6
39	V:V:V164	V:V:V20	52.7925	6.41	No	No	0	8	6
40	V:V:S13	V:V:V164	17.8148	3.23	No	No	0	8	8
41	V:V:F61	V:V:G316	48.4759	4.52	Yes	No	0	9	8
42	V:V:G316	V:V:P124	48.549	4.06	No	Yes	0	8	9
43	V:V:S86	V:V:V55	20.5976	1.62	Yes	Yes	12	6	8
44	V:V:S86	V:V:V41	40.4752	1.62	Yes	Yes	0	6	5
45	V:V:F117	V:V:V84	20.7325	3.93	Yes	No	12	8	3
46	V:V:S86	V:V:V84	20.5748	1.62	Yes	No	12	6	3
47	V:V:K11	V:V:V164	41.4531	4.55	Yes	No	0	9	8
48	R:R:?1360	V:V:K11	22.5967	12.74	Yes	Yes	0	6	9
49	R:R:?1360	V:V:R25	17.76	13.97	Yes	No	0	6	9
50	V:V:K11	V:V:L166	18.1046	11.28	Yes	No	0	9	8
51	V:V:L166	V:V:R25	17.2235	3.64	No	No	0	8	9
52	V:V:F115	V:V:G39	11.8012	3.01	No	No	0	9	8
53	V:V:D38	V:V:G39	11.5852	3.35	No	No	0	7	8
54	V:V:D38	V:V:Q101	10.9347	3.92	No	Yes	0	7	9
55	V:V:N15	V:V:S13	12.9424	4.47	No	No	0	8	8
56	V:V:L293	V:V:R25	34.0911	8.5	Yes	No	0	8	9
57	V:V:H362	V:V:L293	16.2707	5.14	Yes	Yes	2	1	8
58	V:V:E169	V:V:L293	15.1678	3.98	Yes	Yes	2	9	8
59	V:V:L123	V:V:Y144	32.9729	3.52	No	No	0	6	7
60	V:V:K170	V:V:Y144	32.6614	10.75	No	No	0	9	7
61	V:V:D29	V:V:K170	32.6238	12.44	No	No	0	9	9
62	V:V:D29	V:V:Q172	37.9536	10.44	No	No	0	9	9
63	V:V:L305	V:V:Q172	33.0422	3.99	No	No	0	5	9
64	V:V:L305	V:V:M352	32.7389	5.65	No	No	0	5	8
65	V:V:M352	V:V:T350	32.2897	6.02	No	No	0	8	4
66	V:V:E206	V:V:T350	32.0785	5.64	Yes	No	0	7	4
67	V:V:E206	V:V:F349	23.1958	3.5	Yes	Yes	0	7	7
68	V:V:F349	V:V:Y321	16.098	7.22	Yes	Yes	8	7	9
69	V:V:L351	V:V:Y321	12.0505	8.21	No	Yes	0	8	9
70	V:V:H210	V:V:L351	11.9797	9	Yes	No	0	9	8
71	V:V:D290	V:V:E169	10.2803	3.9	No	Yes	0	9	9
72	V:V:V28	V:V:Y173	11.4226	6.31	No	Yes	2	8	4
73	V:V:L18	V:V:V41	10.5722	2.98	No	Yes	0	6	5
74	V:V:F349	V:V:L203	10.009	3.65	Yes	Yes	8	7	8
75	R:R:H135	V:V:L71	34.4607	14.14	Yes	No	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F148	R:R:Y277	6.19	0	No	Yes	1	1	0	1
L:L:Y149	R:R:F181	13.41	0	No	No	5	4	0	1
L:L:F150	R:R:E269	10.49	3	Yes	Yes	4	4	0	1
L:L:F150	R:R:S278	3.96	3	Yes	No	4	2	0	1
L:L:F150	R:R:Q283	8.2	3	Yes	Yes	4	3	0	1
L:L:P151	R:R:H273	4.58	0	No	No	9	3	0	1
L:L:G152	R:R:Y188	4.35	0	No	Yes	9	3	0	1
L:L:G152	R:R:N189	3.39	0	No	No	9	4	0	1
L:L:Q153	R:R:Y96	3.38	0	No	No	6	6	0	1
L:L:Q153	R:R:N189	9.24	0	No	No	6	4	0	1
L:L:F154	R:R:F101	9.65	0	No	No	6	4	0	1
L:L:F156	R:R:F86	6.43	6	Yes	Yes	9	7	0	1
L:L:F156	R:R:F89	4.29	6	Yes	No	9	6	0	1
L:L:F156	R:R:Y93	8.25	6	Yes	Yes	9	6	0	1
L:L:F156	R:R:T290	5.19	6	Yes	No	9	6	0	1
L:L:F156	R:R:F294	3.22	6	Yes	No	9	7	0	1
L:L:S157	R:R:K210	3.06	0	No	No	5	6	0	1
R:R:Y45	R:R:Y93	7.94	6	Yes	Yes	8	6	2	1
R:R:T290	R:R:Y45	4.99	6	No	Yes	6	8	1	2
R:R:F86	R:R:L87	3.65	6	Yes	No	7	6	1	2
R:R:F86	R:R:N120	6.04	6	Yes	No	7	8	1	2
R:R:F294	R:R:F86	15	6	No	Yes	7	7	1	1
R:R:F86	R:R:S297	6.61	6	Yes	No	7	8	1	2
R:R:L87	R:R:L90	4.15	0	No	Yes	6	7	2	2
R:R:F89	R:R:Y93	6.19	6	No	Yes	6	6	1	1
R:R:A117	R:R:F89	8.32	0	No	No	6	6	2	1
R:R:L90	R:R:Y93	3.52	0	Yes	Yes	7	6	2	1
R:R:F294	R:R:L90	12.18	6	No	Yes	7	7	1	2
R:R:Y93	R:R:Y96	4.96	6	Yes	No	6	6	1	1
R:R:T290	R:R:Y93	4.99	6	No	Yes	6	6	1	1
R:R:W103	R:R:Y96	60.77	9	Yes	No	9	6	2	1
R:R:F101	R:R:H102	6.79	0	No	Yes	4	5	1	2
R:R:F122	R:R:K210	7.44	10	Yes	No	6	6	2	1
R:R:D177	R:R:Y188	3.45	15	No	Yes	5	3	2	1
R:R:D177	R:R:N190	4.04	15	No	No	5	3	2	2
R:R:V179	R:R:Y188	10.09	0	No	Yes	1	3	2	1
R:R:F181	R:R:N182	3.62	0	No	No	4	3	1	2
R:R:N190	R:R:Y188	11.63	15	No	Yes	3	3	2	1
R:R:K210	R:R:Y262	4.78	0	No	Yes	6	6	1	2
R:R:F265	R:R:Y262	10.32	3	Yes	Yes	4	6	2	2
R:R:E269	R:R:F265	9.33	3	Yes	Yes	4	4	1	2
R:R:F265	R:R:I286	6.28	3	Yes	No	4	4	2	2
R:R:E269	R:R:S266	5.75	3	Yes	No	4	5	1	2
R:R:E269	R:R:L270	3.98	3	Yes	Yes	4	5	1	2
R:R:E269	R:R:Q283	7.65	3	Yes	Yes	4	3	1	1
R:R:I272	R:R:Q283	4.12	0	No	Yes	2	3	2	1
R:R:H279	R:R:Y277	4.36	14	No	Yes	1	1	2	1
R:R:H280	R:R:Y277	16.33	14	No	Yes	3	1	2	1
R:R:H279	R:R:H280	23.88	14	No	No	1	3	2	2
R:R:I286	R:R:Q283	5.49	0	No	Yes	4	3	2	1
R:R:A284	R:R:F101	2.77	0	No	No	2	4	2	1
R:R:S276	R:R:Y277	1.27	0	No	Yes	3	1	2	1
R:R:H273	R:R:H274	1.19	0	No	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9UYH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.06
Number of Linked Nodes	609
Number of Links	693
Number of Hubs	89
Number of Links mediated by Hubs	331
Number of Communities	25
Number of Nodes involved in Communities	126
Number of Links involved in Communities	158

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	615807
Length Of Smallest Path	3
Average Path Length	27.5075
Length of Longest Path	51
Minimum Path Strength	1.27
Average Path Strength	6.33418
Maximum Path Strength	42.91
Minimum Path Correlation	0.7
Average Path Correlation	0.965638
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	41.012
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9508
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• humoral immune response • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • immune response • defense response to symbiont • response to external stimulus • antimicrobial humoral response • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • immune system process • antifungal humoral response • response to external biotic stimulus • response to fungus • developmental process • cellular developmental process • cell differentiation • cellular process • chemotaxis • positive regulation of locomotion • regulation of biological process • regulation of response to external stimulus • biological regulation • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • response to activity • multicellular organismal process • digestive system development • tube development • animal organ development • embryo development • digestive tract development • multicellular organism development • anatomical structure development • embryonic organ development • embryonic digestive tract development • system development • innate immune response • lipid catabolic process • catabolic process • regulation of cellular process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • response to nutrient levels • response to caloric restriction • cellular response to stimulus • regulation of cell motility • macrophage migration • positive regulation of cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • antifungal innate immune response • cellular response to nitrogen compound • signaling • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cell communication • cellular response to endogenous stimulus • response to hormone • signal transduction • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • macromolecule metabolic process • inflammatory response • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • positive regulation of systemic arterial blood pressure • system process • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • regulation of biological quality • blood circulation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle • organelle lumen • platelet dense granule • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • cell periphery • extracellular matrix • external encapsulating structure • extracellular region • extracellular space • protein binding • binding • arrestin family protein binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • angiotensin receptor binding • signaling receptor binding • G protein-coupled receptor binding • molecular adaptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • insulin-like growth factor receptor binding • molecular function inhibitor activity • enzyme inhibitor activity • transcription coactivator activity • transcription regulator activity • transcription coregulator activity • protein-macromolecule adaptor activity • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • interleukin-6 production • multicellular organismal process • regulation of cellular process • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of biological process • negative regulation of metabolic process • biological regulation • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of interleukin-6 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • negative regulation of post-translational protein modification • regulation of protein modification process • regulation of protein ubiquitination • regulation of primary metabolic process • protein ubiquitination • negative regulation of protein modification process • protein metabolic process • negative regulation of protein ubiquitination • regulation of protein modification by small protein conjugation or removal • protein modification process • negative regulation of protein metabolic process • negative regulation of protein modification by small protein conjugation or removal • regulation of post-translational protein modification • regulation of protein metabolic process • primary metabolic process • macromolecule modification • post-translational protein modification • protein modification by small protein conjugation • protein modification by small protein conjugation or removal • actomyosin structure organization • actin cytoskeleton organization • actin filament organization • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • actin filament bundle organization • contractile actin filament bundle assembly • actin filament-based process • actin filament bundle assembly • stress fiber assembly • cellular component organization or biogenesis • supramolecular fiber organization • cytoskeleton organization • cellular response to stimulus • negative adaptation of signaling pathway • response to stimulus • negative regulation of signaling • signaling • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cell communication • signal transduction • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • G protein-coupled receptor signaling pathway • system process • sensory perception • nervous system process • catabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • regulation of system process • positive regulation of biological process • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • positive regulation of multicellular organismal process • negative regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • import into cell • receptor internalization • transport • vesicle-mediated transport • localization • G protein-coupled receptor internalization • establishment of localization • receptor-mediated endocytosis • endocytosis • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • establishment of protein localization • protein transport • macromolecule localization • intracellular protein localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • proteasomal protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • cell surface receptor signaling pathway • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of phosphorus metabolic process • regulation of phosphorylation • cell projection • pseudopodium • plasma membrane bounded cell projection • clathrin-coated pit • membrane • cytosol • membraneless organelle • intracellular membraneless organelle • chromatin • chromosome • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • endocytic vesicle membrane • organelle membrane • endocytic vesicle • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi membrane • Golgi apparatus • plasma membrane • nucleus • nucleoplasm • nuclear lumen • nuclear body • vasopressin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • adipokinetic hormone binding • peptide hormone binding • hormone binding • protein-hormone receptor activity • adipokinetic hormone receptor activity • neuropeptide binding • peptide binding • regulation of body fluid levels • hemostasis • regulation of biological quality • regulation of tube diameter • regulation of tube size • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • renal system process • fluid transport • water transport • renal water transport • multicellular organismal-level homeostasis • renal absorption • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water absorption • renal water homeostasis • positive regulation of gene expression • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • neuropeptide signaling pathway • clathrin-coated vesicle • coated vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • coated vesicle membrane • endosome • perinuclear region of cytoplasm • endoplasmic reticulum • neuron projection
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TPO
PDB Residues	R:R:?1359 R:R:?1360
Environment Details	Open EMBL-EBI Page
Code	TPO
Name	PHOSPHOTHREONINE
Synonyms	PHOSPHONOTHREONINE
Identifier
Formula	C4 H10 N O6 P
Molecular Weight	199.099
SMILES
PubChem	139055008
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	2
Total Bonds	21
Total Aromatic Bonds	0


Code	SEP
PDB Residues	R:R:?1362 R:R:?1363 R:R:?1364
Environment Details	Open EMBL-EBI Page
Code	SEP
Name	Dexfosfoserine
Synonyms	PHOSPHONOSERINE
Identifier
Formula	C3 H8 N O6 P
Molecular Weight	185.072
SMILES
PubChem	57689797
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Chemerin-9
UniProt	Q99969
Sequence	>9UYH_nogp_Chain_L F Y F P G Q F A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46091
Sequence	>9UYH_nogp_Chain_R V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W K K T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N F H W P F G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H P V L S H R H R T L K N S L I V I I F I W L L A S L I G G P A L Y F R D T V E F N N H T L C Y N N L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S I L I S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H N S Y S H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F Q A R F R S C ??A ?? ?L A K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P49407
Sequence	>9UYH_nogp_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V D P V D G V V L V D P E Y L K E R R V Y V T L T A F R Y G R E D L D V L G L T F R K D L F V A N V Q S F P K K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P S V T L Q P G P E D T G K A G V D Y E V K A F A E N L E E K I H K R N S V R L V I K V Q Y A P E R P G P Q P T A E T T R Q L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I L F N T A Q Y K P V A M E E A D D T V A P S S T F K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V D V A V E L P F T L M H P K P K E E P P H R E V P E N A S I V E V V S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JJP	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8JJP (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	9L3Y	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Y (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9UYH	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYH (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYI	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.2	2025-11-19	10.1126/science.adt8794
	9UYI (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.2	2025-11-19	10.1126/science.adt8794
	9UYJ	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYJ (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYL	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYL (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	chim(Arrestin3-CtArrestin2)	3.5	2025-11-19	10.1126/science.adt8794
	9UYM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.5	2025-11-19	10.1126/science.adt8794
	9UYN	A	Protein	Chemerin	CML2	Homo sapiens	-	-	Arrestin2	2.9	2025-11-19	10.1126/science.adt8794
	9UYN (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	-	-		2.9	2025-11-19	10.1126/science.adt8794

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