Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y149 5.645415
2L:L:Q153 8.764516
3L:L:F154 5.664516
4L:L:F156 6.18167619
5L:L:S157 7.384515
6R:R:H38 5.455405
7R:R:Y45 6.09333618
8R:R:I60 3.5575407
9R:R:F62 6.52333687
10R:R:K68 10.285407
11R:R:W75 5.545607
12R:R:D83 4.78509
13R:R:F86 4.92417
14R:R:Y93 6.9575416
15R:R:Y96 6.916516
16R:R:V97 5.4875415
17R:R:W103 6.36667619
18R:R:N120 6.4175408
19R:R:M121 3.682507
20R:R:F127 4.6597
21R:R:L128 4.704529
22R:R:D134 6.595428
23R:R:H135 5.68167629
24R:R:H138 4.4175428
25R:R:R149 5.556527
26R:R:S154 3.49407
27R:R:W162 5.09499
28R:R:D177 3.9975415
29R:R:T178 4.4425415
30R:R:L186 5.23413
31R:R:C187 5.2075419
32R:R:Y188 7.408513
33R:R:N190 5.2413
34R:R:H203 4.705414
35R:R:Y215 9.124118
36R:R:M222 5.555428
37R:R:Y226 7.12429
38R:R:I230 3.8225424
39R:R:K234 4.8775405
40R:R:H244 5.475427
41R:R:I248 6.366527
42R:R:F255 7.58429
43R:R:W259 6.23608
44R:R:H263 9.26754118
45R:R:I286 4.724504
46R:R:P287 3.7225414
47R:R:F294 7.854517
48R:R:N300 6.57429
49R:R:Y304 4.58429
50R:R:K310 4.315406
51R:R:?1360 11.96506
52R:R:?1363 14.686547
53R:R:?1364 12.6625445
54R:R:L1365 7.364545
55V:V:K11 7.5409
56V:V:T19 4.255447
57V:V:Y21 6.735648
58V:V:R25 6.8525409
59V:V:D26 7.0075439
60V:V:D38 7.925447
61V:V:V40 3.9375448
62V:V:D44 6.275408
63V:V:Y47 5.448565
64V:V:R52 8.02456
65V:V:Y54 7.688554
66V:V:V55 6.994128
67V:V:T56 4.55457
68V:V:F61 4.40429729
69V:V:D69 4.946509
70V:V:F75 6.02167609
71V:V:K77 7.3075429
72V:V:L79 4.9425428
73V:V:Q101 6.116549
74V:V:L104 4.4725449
75V:V:K107 5.7125449
76V:V:L108 5.326548
77V:V:Y113 3.0675463
78V:V:P114 4.965448
79V:V:F115 5.285717129
80V:V:F117 7.6165128
81V:V:P120 5.405407
82V:V:L123 3.45426
83V:V:K147 10.0825457
84V:V:F149 7.904555
85V:V:L154 6.875453
86V:V:L166 4.1025408
87V:V:E169 7.395439
88V:V:K170 7.6225409
89V:V:Y173 5.93534
90V:V:L203 4.32571738
91V:V:Y208 9.93536
92V:V:H210 9.328539
93V:V:I214 6.25438
94V:V:V228 3.9125408
95V:V:I233 3.46754155
96V:V:V235 4.1225438
97V:V:R236 7.342575
98V:V:Q237 7.426539
99V:V:Y238 10.4975474
100V:V:L243 6.9725427
101V:V:F244 5.18528
102V:V:Y249 2.4225407
103V:V:V253 3.404509
104V:V:V262 4.5075407
105V:V:Y272 7.926676154
106V:V:P276 3.8475409
107V:V:N281 6.96409
108V:V:L287 4.676507
109V:V:D290 5.5175439
110V:V:L293 4.495438
111V:V:S302 4.68439
112V:V:Y321 9.9225439
113V:V:V323 3.6925437
114V:V:V345 3.985407
115V:V:L347 4.262536
116V:V:F349 4.56714737
117V:V:H353 6.51833638
118V:V:P360 6531
119V:V:H362 10.7725431
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F154 R:R:Y188 20.68086.19YesYes163
2L:L:F154 R:R:Y96 24.69823.09YesYes166
3R:R:I286 R:R:Q283 10.3296.86YesNo043
4R:R:Y93 R:R:Y96 29.2657.94YesYes166
5L:L:F156 R:R:Y93 32.661612.38YesYes196
6L:L:F156 R:R:M121 41.23062.49YesYes097
7R:R:I286 R:R:S289 12.04053.1YesNo047
8R:R:S289 R:R:Y262 12.60272.54NoNo076
9R:R:M121 R:R:Q118 11.44762.72YesNo075
10R:R:M121 R:R:W259 58.3726.98YesYes078
11R:R:N296 R:R:W259 17.21935.65NoYes098
12R:R:N296 R:R:N300 17.7189.54NoYes099
13R:R:H263 R:R:Y262 13.16766.53YesNo086
14R:R:H263 R:R:W259 17.16674.23YesYes088
15R:R:F255 R:R:W259 59.999913.03YesYes098
16R:R:F255 R:R:L128 19.37032.44YesYes299
17R:R:L128 R:R:Y304 19.45775.86YesYes299
18R:R:F76 R:R:Y304 39.14654.13NoYes089
19R:R:N300 R:R:Y304 19.44885.81YesYes299
20R:R:F76 V:V:V70 39.40153.93NoNo089
21R:R:H135 V:V:V70 39.52212.77YesNo099
22R:R:H135 R:R:H138 21.00765.97YesYes298
23R:R:F255 R:R:M222 48.184311.2YesYes298
24R:R:M222 R:R:Y226 48.47913.59YesYes289
25R:R:I248 R:R:Y226 52.59059.67YesYes279
26R:R:H244 R:R:I248 21.789210.61YesYes277
27R:R:H135 R:R:H244 21.92874.78YesYes297
28R:R:I248 V:V:L71 21.78954.28YesNo277
29R:R:H135 V:V:L71 21.912911.57YesNo297
30R:R:H138 V:V:F75 24.71264.53YesYes089
31R:R:H135 V:V:L73 20.96322.57YesNo298
32V:V:F75 V:V:L73 20.98596.09YesNo098
33R:R:H135 R:R:L139 41.50026.43YesNo298
34R:R:L139 V:V:F244 41.55266.09NoYes288
35R:R:I230 R:R:I248 10.89384.42YesYes247
36R:R:I230 R:R:L229 11.59985.71YesNo047
37R:R:K234 R:R:L229 11.65755.64YesNo057
38R:R:K234 V:V:F244 11.83912.48YesYes058
39V:V:F75 V:V:Y63 46.72618.25YesNo099
40V:V:F61 V:V:Y63 46.72848.25YesNo299
41V:V:F244 V:V:L243 26.9528.53YesYes287
42V:V:F61 V:V:L243 26.96422.44YesYes297
43R:R:I238 V:V:F244 26.61217.54NoYes248
44R:R:I238 V:V:K77 26.62644.36NoYes249
45V:V:F61 V:V:L79 72.92612.44YesYes298
46V:V:L123 V:V:L79 99.46472.77YesYes268
47V:V:L123 V:V:P120 99.17013.28YesYes067
48V:V:F80 V:V:P120 10013NoYes047
49V:V:F80 V:V:L57 99.96032.44NoNo047
50V:V:F117 V:V:L57 99.940414.61YesNo087
51V:V:F115 V:V:F117 76.67466.43YesYes1298
52V:V:F115 V:V:V20 25.43852.62YesNo096
53V:V:K77 V:V:L79 26.656211.28YesYes298
54V:V:L166 V:V:V20 24.41972.98YesNo086
55V:V:F115 V:V:L22 24.45652.44YesNo098
56V:V:L166 V:V:L22 24.41274.15YesNo088
57V:V:F117 V:V:V37 23.08287.87YesNo088
58V:V:F27 V:V:V37 23.03789.18NoNo088
59V:V:F27 V:V:I168 22.95212.51NoNo088
60V:V:I168 V:V:R25 46.33712.51NoYes089
61V:V:F115 V:V:V146 23.52932.62YesNo096
62V:V:I168 V:V:V146 23.48444.61NoNo086
63V:V:L166 V:V:R25 46.89333.64YesYes089
64V:V:L293 V:V:R25 91.9597.29YesYes089
65V:V:H362 V:V:L293 47.02082.57YesYes318
66V:V:D26 V:V:H362 43.916512.61YesYes391
67V:V:E169 V:V:L293 44.53766.63YesYes398
68V:V:E169 V:V:V171 43.92612.85YesNo396
69V:V:V171 V:V:Y173 43.72215.05NoYes364
70V:V:D26 V:V:Y173 43.75184.6YesYes394
71V:V:H353 V:V:Y173 85.05252.18YesYes384
72V:V:H210 V:V:H353 72.660916.72YesYes398
73V:V:H210 V:V:L351 56.105810.29YesNo398
74V:V:H210 V:V:L300 16.19942.57YesNo099
75V:V:F349 V:V:L351 53.19974.87YesNo378
76V:V:F349 V:V:L203 38.70763.65YesYes378
77V:V:L203 V:V:V216 29.19812.98YesNo087
78V:V:I233 V:V:V216 28.7823.07YesNo057
79V:V:I233 V:V:V325 13.76983.07YesNo058
80V:V:I233 V:V:Y272 14.18673.63YesYes1554
81V:V:L327 V:V:V228 10.01844.47NoYes078
82V:V:L347 V:V:P348 15.02791.64YesNo069
83V:V:K322 V:V:P348 14.19336.69NoNo059
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y149 R:R:V179 6.31 1 Yes No 5 1 0 1
L:L:Y149 R:R:F181 5.16 1 Yes No 5 4 0 1
L:L:Y149 R:R:Q192 6.76 1 Yes No 5 4 0 1
L:L:P151 R:R:H273 16.78 1 No No 9 3 0 1
L:L:Q153 R:R:Y188 6.76 1 Yes Yes 6 3 0 1
L:L:Q153 R:R:E269 5.1 1 Yes No 6 4 0 1
L:L:Q153 R:R:L270 7.99 1 Yes No 6 5 0 1
L:L:Q153 R:R:H273 16.07 1 Yes No 6 3 0 1
L:L:F154 R:R:Y96 3.09 1 Yes Yes 6 6 0 1
L:L:F154 R:R:F101 7.5 1 Yes No 6 4 0 1
L:L:F154 R:R:L186 8.53 1 Yes Yes 6 3 0 1
L:L:F154 R:R:Y188 6.19 1 Yes Yes 6 3 0 1
L:L:A155 R:R:I286 6.5 0 No Yes 9 4 0 1
L:L:F156 R:R:Y93 12.38 1 Yes Yes 9 6 0 1
L:L:F156 R:R:A117 2.77 1 Yes No 9 6 0 1
L:L:F156 R:R:M121 2.49 1 Yes Yes 9 7 0 1
L:L:F156 R:R:Y262 10.32 1 Yes No 9 6 0 1
L:L:F156 R:R:T290 6.49 1 Yes No 9 6 0 1
L:L:S157 R:R:S114 8.14 1 Yes No 5 5 0 1
L:L:S157 R:R:Q118 18.77 1 Yes No 5 5 0 1
L:L:S157 R:R:A172 3.42 1 Yes No 5 4 0 1
L:L:S157 R:R:R176 3.95 1 Yes No 5 4 0 1
R:R:V97 R:R:Y45 11.36 1 Yes Yes 5 8 2 2
R:R:P287 R:R:Y45 4.17 1 Yes Yes 4 8 2 2
R:R:T290 R:R:Y45 4.99 1 No Yes 6 8 1 2
R:R:F86 R:R:M121 2.49 1 Yes Yes 7 7 2 1
R:R:Y93 R:R:Y96 7.94 1 Yes Yes 6 6 1 1
R:R:V97 R:R:Y93 2.52 1 Yes Yes 5 6 2 1
R:R:T290 R:R:Y93 4.99 1 No Yes 6 6 1 1
R:R:F101 R:R:Y96 11.35 1 No Yes 4 6 1 1
R:R:W103 R:R:Y96 8.68 1 Yes Yes 9 6 2 1
R:R:L186 R:R:Y96 3.52 1 Yes Yes 3 6 1 1
R:R:P287 R:R:V97 5.3 1 Yes Yes 4 5 2 2
R:R:F101 R:R:L186 2.44 1 No Yes 4 3 1 1
R:R:C187 R:R:W103 2.61 1 Yes Yes 9 9 2 2
R:R:R176 R:R:S114 13.18 1 No No 4 5 1 1
R:R:M121 R:R:Q118 2.72 0 Yes No 7 5 1 1
R:R:K210 R:R:Q118 4.07 0 No No 6 5 2 1
R:R:F122 R:R:M121 3.73 0 No Yes 6 7 2 1
R:R:M121 R:R:W259 6.98 0 Yes Yes 7 8 1 2
R:R:F122 R:R:K210 3.72 0 No No 6 6 2 2
R:R:C187 R:R:R176 4.18 1 Yes No 9 4 2 1
R:R:D177 R:R:V179 4.38 1 Yes No 5 1 2 1
R:R:D177 R:R:Y188 3.45 1 Yes Yes 5 3 2 1
R:R:F181 R:R:V179 7.87 1 No No 4 1 1 1
R:R:H184 R:R:L186 6.43 0 No Yes 3 3 2 1
R:R:N189 R:R:Y188 16.28 1 No Yes 4 3 2 1
R:R:H203 R:R:Y188 4.36 1 Yes Yes 4 3 2 1
R:R:H203 R:R:N189 5.1 1 Yes No 4 4 2 2
R:R:Q192 R:R:R202 4.67 0 No No 4 1 1 2
R:R:H203 R:R:L270 2.57 1 Yes No 4 5 2 1
R:R:L270 R:R:T207 4.42 0 No No 5 5 1 2
R:R:H263 R:R:W259 4.23 11 Yes Yes 8 8 2 2
R:R:H263 R:R:Y262 6.53 11 Yes No 8 6 2 1
R:R:S289 R:R:Y262 2.54 0 No No 7 6 2 1
R:R:F265 R:R:I286 3.77 0 No Yes 4 4 2 1
R:R:E269 R:R:Q283 2.55 0 No No 4 3 1 2
R:R:H280 R:R:V281 6.92 0 No No 3 1 1 2
R:R:I286 R:R:Q283 6.86 0 Yes No 4 3 1 2
R:R:I286 R:R:P287 3.39 0 Yes Yes 4 4 1 2
R:R:I286 R:R:S289 3.1 0 Yes No 4 7 1 2
L:L:S147 R:R:S278 1.63 0 No No 3 2 0 1
R:R:A117 R:R:N113 1.56 0 No No 6 5 1 2
R:R:E269 R:R:S266 1.44 0 No No 4 5 1 2
L:L:F150 R:R:H280 1.13 0 No No 4 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9UYI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.44
Number of Linked Nodes 605
Number of Links 742
Number of Hubs 119
Number of Links mediated by Hubs 418
Number of Communities 15
Number of Nodes involved in Communities 167
Number of Links involved in Communities 236
Path Summary
Number Of Nodes in MetaPath 84
Number Of Links MetaPath 83
Number of Shortest Paths 6880651
Length Of Smallest Path 3
Average Path Length 36.3061
Length of Longest Path 56
Minimum Path Strength 1.23
Average Path Strength 6.01706
Maximum Path Strength 24.11
Minimum Path Correlation 0.7
Average Path Correlation 0.988727
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 25.6281
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.1402
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• humoral immune response   • biological process involved in interspecies interaction between organisms   • response to stimulus   • response to other organism   • defense response   • immune response   • defense response to symbiont   • response to external stimulus   • antimicrobial humoral response   • response to biotic stimulus   • defense response to fungus   • defense response to other organism   • response to stress   • immune system process   • antifungal humoral response   • response to external biotic stimulus   • response to fungus   • developmental process   • cellular developmental process   • cell differentiation   • cellular process   • chemotaxis   • positive regulation of locomotion   • regulation of biological process   • regulation of response to external stimulus   • biological regulation   • positive regulation of biological process   • regulation of chemotaxis   • positive regulation of chemotaxis   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • taxis   • regulation of response to stimulus   • response to chemical   • regulation of locomotion   • locomotion   • response to activity   • multicellular organismal process   • digestive system development   • tube development   • animal organ development   • embryo development   • digestive tract development   • multicellular organism development   • anatomical structure development   • embryonic organ development   • embryonic digestive tract development   • system development   • innate immune response   • lipid catabolic process   • catabolic process   • regulation of cellular process   • regulation of lipid metabolic process   • primary metabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • regulation of primary metabolic process   • metabolic process   • regulation of metabolic process   • lipid metabolic process   • response to nutrient levels   • response to caloric restriction   • cellular response to stimulus   • regulation of cell motility   • macrophage migration   • positive regulation of cell migration   • cell migration   • regulation of immune system process   • regulation of mononuclear cell migration   • positive regulation of immune system process   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of macrophage migration   • positive regulation of leukocyte chemotaxis   • granulocyte migration   • leukocyte migration   • macrophage chemotaxis   • regulation of granulocyte chemotaxis   • regulation of macrophage migration   • positive regulation of cell motility   • regulation of cell migration   • myeloid leukocyte migration   • positive regulation of mononuclear cell migration   • cell motility   • positive regulation of cellular process   • cell chemotaxis   • regulation of macrophage chemotaxis   • positive regulation of leukocyte migration   • cellular response to chemical stimulus   • granulocyte chemotaxis   • mononuclear cell migration   • positive regulation of macrophage chemotaxis   • leukocyte chemotaxis   • antifungal innate immune response   • cellular response to nitrogen compound   • signaling   • response to peptide hormone   • insulin receptor signaling pathway   • cell surface receptor protein tyrosine kinase signaling pathway   • cell communication   • cellular response to endogenous stimulus   • response to hormone   • signal transduction   • enzyme-linked receptor protein signaling pathway   • cellular response to hormone stimulus   • cell surface receptor signaling pathway   • response to endogenous stimulus   • response to oxygen-containing compound   • cellular response to peptide hormone stimulus   • response to nitrogen compound   • cellular response to oxygen-containing compound   • response to insulin   • cellular response to insulin stimulus   • defense response to Gram-negative bacterium   • defense response to bacterium   • response to bacterium   • positive regulation of phosphorylation   • regulation of protein modification process   • regulation of protein phosphorylation   • positive regulation of protein metabolic process   • positive regulation of phosphate metabolic process   • positive regulation of metabolic process   • positive regulation of protein modification process   • phosphate-containing compound metabolic process   • positive regulation of macromolecule metabolic process   • protein metabolic process   • positive regulation of protein phosphorylation   • phosphorus metabolic process   • protein modification process   • protein phosphorylation   • positive regulation of phosphorus metabolic process   • phosphorylation   • regulation of protein metabolic process   • regulation of macromolecule metabolic process   • macromolecule modification   • regulation of phosphorus metabolic process   • regulation of phosphorylation   • macromolecule metabolic process   • inflammatory response   • fat cell differentiation   • positive regulation of fat cell differentiation   • regulation of developmental process   • regulation of cell differentiation   • positive regulation of developmental process   • positive regulation of cell differentiation   • regulation of fat cell differentiation   • positive regulation of systemic arterial blood pressure   • system process   • regulation of systemic arterial blood pressure   • circulatory system process   • regulation of blood pressure   • positive regulation of blood pressure   • regulation of biological quality   • blood circulation   • diterpenoid metabolic process   • retinoid metabolic process   • terpenoid metabolic process   • isoprenoid metabolic process   • defense response to Gram-positive bacterium   • membrane-bounded organelle   • vesicle lumen   • intracellular anatomical structure   • intracellular vesicle   • membrane-enclosed lumen   • cytoplasmic vesicle lumen   • intracellular membrane-bounded organelle   • secretory granule lumen   • endomembrane system   • intracellular organelle lumen   • intracellular organelle   • cellular anatomical structure   • platelet dense granule lumen   • cytoplasmic vesicle
Gene OntologyCellular Component• membrane-bounded organelle   • vesicle lumen   • intracellular anatomical structure   • intracellular vesicle   • membrane-enclosed lumen   • cytoplasmic vesicle lumen   • intracellular membrane-bounded organelle   • secretory granule lumen   • endomembrane system   • intracellular organelle lumen   • intracellular organelle   • cellular anatomical structure   • platelet dense granule lumen   • cytoplasmic vesicle   • organelle lumen   • platelet dense granule   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • cell periphery   • extracellular matrix   • external encapsulating structure   • extracellular region   • extracellular space   • vasopressin receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • binding   • adipokinetic hormone binding   • peptide hormone binding   • hormone binding   • protein-hormone receptor activity   • adipokinetic hormone receptor activity   • neuropeptide binding   • peptide binding   • regulation of body fluid levels   • hemostasis   • biological regulation   • regulation of biological quality   • regulation of tube diameter   • multicellular organismal process   • regulation of biological process   • system process   • regulation of tube size   • regulation of system process   • positive regulation of biological process   • positive regulation of vasoconstriction   • circulatory system process   • regulation of blood circulation   • vascular process in circulatory system   • regulation of vasoconstriction   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • blood vessel diameter maintenance   • vasoconstriction   • blood circulation   • regulation of anatomical structure size   • renal system process   • transport   • homeostatic process   • fluid transport   • establishment of localization   • water transport   • renal water transport   • localization   • multicellular organismal-level homeostasis   • chemical homeostasis   • renal absorption   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water absorption   • renal water homeostasis   • regulation of biosynthetic process   • regulation of cellular process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • cellular process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • cellular response to stimulus   • response to stimulus   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to endogenous stimulus   • response to chemical   • cellular response to hormone stimulus   • response to peptide   • response to cytokine   • regulation of systemic arterial blood pressure by hormone   • regulation of systemic arterial blood pressure mediated by a chemical signal   • regulation of blood pressure   • regulation of systemic arterial blood pressure   • endocrine process   • regulation of systemic arterial blood pressure by vasopressin   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of cell communication   • regulation of signaling   • positive regulation of signal transduction   • positive regulation of intracellular signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • regulation of urine volume   • renal water retention   • negative regulation of urine volume   • developmental process   • head development   • forebrain development   • animal organ development   • brain development   • nervous system development   • multicellular organism development   • central nervous system development   • anatomical structure development   • telencephalon development   • system development   • negative regulation of cell population proliferation   • negative regulation of cellular process   • negative regulation of biological process   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • positive regulation of systemic arterial blood pressure   • positive regulation of blood pressure   • neuropeptide signaling pathway   • glucose homeostasis   • carbohydrate homeostasis   • membrane   • bounding membrane of organelle   • vesicle membrane   • clathrin-coated vesicle   • endocytic vesicle membrane   • coated vesicle   • endocytic vesicle   • clathrin-coated vesicle membrane   • clathrin-coated endocytic vesicle membrane   • clathrin-coated endocytic vesicle   • cytoplasmic vesicle membrane   • coated vesicle membrane   • organelle membrane   • plasma membrane   • Golgi apparatus   • endosome   • perinuclear region of cytoplasm   • endoplasmic reticulum   • nucleus   • nucleoplasm   • nuclear lumen   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • protein binding   • arrestin family protein binding   • GTPase regulator activity   • enzyme regulator activity   • enzyme activator activity   • GTPase activator activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • angiotensin receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • molecular adaptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • insulin-like growth factor receptor binding   • molecular function inhibitor activity   • enzyme inhibitor activity   • transcription coactivator activity   • transcription regulator activity   • transcription coregulator activity   • protein-macromolecule adaptor activity   • cellular homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • interleukin-6 production   • regulation of interleukin-6 production   • regulation of cytokine production   • cytokine production   • negative regulation of macromolecule metabolic process   • negative regulation of metabolic process   • negative regulation of cytokine production   • negative regulation of interleukin-6 production   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of multicellular organismal process   • negative regulation of post-translational protein modification   • regulation of protein modification process   • regulation of protein ubiquitination   • regulation of primary metabolic process   • protein ubiquitination   • negative regulation of protein modification process   • protein metabolic process   • negative regulation of protein ubiquitination   • regulation of protein modification by small protein conjugation or removal   • protein modification process   • negative regulation of protein metabolic process   • negative regulation of protein modification by small protein conjugation or removal   • regulation of post-translational protein modification   • regulation of protein metabolic process   • primary metabolic process   • macromolecule modification   • post-translational protein modification   • protein modification by small protein conjugation   • protein modification by small protein conjugation or removal   • actomyosin structure organization   • actin cytoskeleton organization   • actin filament organization   • cellular component organization   • cellular component biogenesis   • organelle organization   • cellular component assembly   • actin filament bundle organization   • contractile actin filament bundle assembly   • actin filament-based process   • actin filament bundle assembly   • stress fiber assembly   • cellular component organization or biogenesis   • supramolecular fiber organization   • cytoskeleton organization   • negative adaptation of signaling pathway   • negative regulation of signaling   • desensitization of G protein-coupled receptor signaling pathway   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • negative regulation of response to stimulus   • negative regulation of signal transduction   • adaptation of signaling pathway   • sensory perception   • nervous system process   • catabolic process   • protein catabolic process   • macromolecule catabolic process   • modification-dependent macromolecule catabolic process   • modification-dependent protein catabolic process   • ubiquitin-dependent protein catabolic process   • muscle hypertrophy   • regulation of muscle adaptation   • positive regulation of cardiac muscle hypertrophy   • striated muscle hypertrophy   • regulation of muscle system process   • muscle system process   • regulation of cardiac muscle hypertrophy   • regulation of muscle hypertrophy   • muscle adaptation   • positive regulation of muscle hypertrophy   • cardiac muscle hypertrophy   • negative regulation of interleukin-8 production   • interleukin-8 production   • regulation of interleukin-8 production   • positive regulation of DNA-templated transcription   • RNA metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • import into cell   • receptor internalization   • vesicle-mediated transport   • G protein-coupled receptor internalization   • receptor-mediated endocytosis   • endocytosis   • positive regulation of ERK1 and ERK2 cascade   • intracellular signaling cassette   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • establishment of protein localization   • protein transport   • macromolecule localization   • intracellular protein localization   • regulation of localization   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of receptor internalization   • positive regulation of endocytosis   • positive regulation of receptor-mediated endocytosis   • regulation of endocytosis   • regulation of transport   • regulation of receptor-mediated endocytosis   • regulation of vesicle-mediated transport   • positive regulation of receptor internalization   • positive regulation of transport   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • Rho protein signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • positive regulation of small GTPase mediated signal transduction   • proteasomal protein catabolic process   • proteasome-mediated ubiquitin-dependent protein catabolic process   • cell surface receptor signaling pathway   • Notch signaling pathway   • negative regulation of Notch signaling pathway   • regulation of Notch signaling pathway   • positive regulation of phosphorylation   • regulation of protein phosphorylation   • positive regulation of protein metabolic process   • positive regulation of phosphate metabolic process   • positive regulation of protein modification process   • phosphate-containing compound metabolic process   • positive regulation of protein phosphorylation   • phosphorus metabolic process   • protein phosphorylation   • positive regulation of phosphorus metabolic process   • phosphorylation   • regulation of phosphorus metabolic process   • regulation of phosphorylation   • pseudopodium   • clathrin-coated pit   • cytosol   • membraneless organelle   • intracellular membraneless organelle   • chromatin   • chromosome   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • Golgi membrane   • nuclear body
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeSEP
PDB ResiduesR:R:?1357 R:R:?1362 R:R:?1363 R:R:?1364
Environment DetailsOpen EMBL-EBI Page
CodeSEP
NameDexfosfoserine
SynonymsPHOSPHONOSERINE
Identifier
FormulaC3 H8 N O6 P
Molecular Weight185.072
SMILES
PubChem57689797
Formal Charge0
Total Atoms19
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0

CodeTPO
PDB ResiduesR:R:?1359 R:R:?1360
Environment DetailsOpen EMBL-EBI Page
CodeTPO
NamePHOSPHOTHREONINE
SynonymsPHOSPHONOTHREONINE
Identifier
FormulaC4 H10 N O6 P
Molecular Weight199.099
SMILES
PubChem139055008
Formal Charge0
Total Atoms22
Total Chiral Atoms2
Total Bonds21
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainL
ProteinChemerin-9
UniProtQ99969
Sequence
>9UYI_nogp_Chain_L
SFYFPGQFA FS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46091
Sequence
>9UYI_nogp_Chain_R
VVHWVSLVL YCLAFVLGI PGNAIVIWF TGFKWKKTV TTLWFLNLA 
IADFIFLLF LPLYISYVA MNFHWPFGI WLCKANSFT AQLNMFASV 
FFLTVISLD HYIHLIHPV LSHRHRTLK NSLIVIIFI WLLASLIGG 
PALYFRDTV EFNNHTLCY NNFQKHDPD LTLIRHHVL TWVKFIIGY 
LFPLLTMSI CYLCLIFKV KKRSILISS RHFWTILVV VVAFVVCWT 
PYHLFSIWE LTIHHNSYS HHVMQAGIP LSTGLAFLN SCLNPILYV 
LISKKFQAR FR?C??A?? ?LAK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainV
ProteinArrestin
UniProtP49407
Sequence
>9UYI_nogp_Chain_V
TRVFKKASP NGKLTVYLG KRDFVDHID LVDPVDGVV LVDPEYLKE 
RRVYVTLTA FRYGREDLD VLGLTFRKD LFVANVQSF PPPLTRLQE 
RLIKKLGEH AYPFTFEIP PNLPSVTLQ PAGVDYEVK AFAENLEEK 
IHKRNSVRL VIKVQYAPE RPGPQPTAE TTRQLHLEA SLDKEIYYH 
GEPISVNVH VTNNTNKTV KKIKISVRQ YADILFNTA QYKPVAMEE 
ADDTVAPSS TFKVYTLTP FLANNREKR GLALDGKLK HEDTNLASS 
TLLREGANR EILGIIVSY KVKVKLVVS DVAVELPFT LMHPKPKEE 
PPHREVPEN ASIVEVVS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JJPAProteinChemerinCML2Homo sapiensChemerin-9-Gi1/β1/γ22.92024-08-21doi.org/10.1371/journal.pbio.3002838
8JJP (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-2.92024-08-21doi.org/10.1371/journal.pbio.3002838
8XGMAProteinChemerinCML2Homo sapiensChemerin-Gi1/β1/γ23.292024-08-21doi.org/10.1371/journal.pbio.3002838
8XGM (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-3.292024-08-21doi.org/10.1371/journal.pbio.3002838
9L3YAProteinChemerinCML2Homo sapiensChemerin-Gi1/β1/γ23.62025-03-12doi.org/10.1093/procel/pwae073
9L3Y (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-3.62025-03-12doi.org/10.1093/procel/pwae073
9UYHAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.32025-11-1910.1126/science.adt8794
9UYH (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.32025-11-1910.1126/science.adt8794
9UYIAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.22025-11-1910.1126/science.adt8794
9UYI (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.22025-11-1910.1126/science.adt8794
9UYJAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.32025-11-1910.1126/science.adt8794
9UYJ (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.32025-11-1910.1126/science.adt8794
9UYLAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.32025-11-1910.1126/science.adt8794
9UYL (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.32025-11-1910.1126/science.adt8794
9UYMAProteinChemerinCML2Homo sapiensChemerin-9-chim(Arrestin3-CtArrestin2)3.52025-11-1910.1126/science.adt8794
9UYM (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.52025-11-1910.1126/science.adt8794
9UYNAProteinChemerinCML2Homo sapiens--Arrestin22.92025-11-1910.1126/science.adt8794
9UYN (No Gprot) AProteinChemerinCML2Homo sapiens--2.92025-11-1910.1126/science.adt8794




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