Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:H38 5.954505
2R:R:Y45 5.12833668
3R:R:I60 3.6154147
4R:R:W67 5.3875406
5R:R:V71 4.915416
6R:R:W75 5.28429717
7R:R:L77 4.474146
8R:R:F86 7.944567
9R:R:H102 6.1725455
10R:R:W103 9.985659
11R:R:F105 7.54833657
12R:R:N120 6.176568
13R:R:F122 5.655406
14R:R:F127 8.9425417
15R:R:H135 7.562519
16R:R:H138 6.55418
17R:R:L139 10.945418
18R:R:I140 7.7165167
19R:R:R149 7.828517
20R:R:W162 5.478519
21R:R:Y188 9.414173
22R:R:F191 7.096505
23R:R:F211 9.09754196
24R:R:Y215 8.3554198
25R:R:P218 4.0125409
26R:R:R243 7.00667617
27R:R:H244 7.082517
28R:R:F245 4.385416
29R:R:L249 3.6125414
30R:R:F255 9.33754159
31R:R:W259 10.1125158
32R:R:Y262 4.068506
33R:R:F294 8.3925467
34R:R:C298 2.925407
35R:R:?1357 6.3575476
36R:R:?1360 9.12167676
37R:R:?1362 10.775424
38R:R:?1363 11.0329727
39R:R:?1364 10.375425
40R:R:L1365 7.03425
41V:V:S13 2.9125408
42V:V:P14 5.7525476
43V:V:Y21 9.152528
44V:V:R25 8.045479
45V:V:Y47 8.126585
46V:V:L48 6.2275434
47V:V:Y54 9.5175404
48V:V:V55 8.055438
49V:V:F61 6.0225239
50V:V:R65 6.4675407
51V:V:L71 3.2925407
52V:V:F75 9.232519
53V:V:F80 5.42254124
54V:V:P88 5.3125409
55V:V:Q101 7.2245109
56V:V:R103 8.2725426
57V:V:L108 6.22408
58V:V:Y113 7.3025433
59V:V:F117 7.148538
60V:V:P120 4.065127
61V:V:L123 3.8454126
62V:V:Q130 4.285409
63V:V:P131 3.215408
64V:V:I140 4.86409
65V:V:Y144 7.455407
66V:V:F149 6.075215
67V:V:R165 5.22505
68V:V:L166 4.75478
69V:V:E169 9.0675409
70V:V:Y173 6.896594
71V:V:H198 5.09754266
72V:V:L199 5.4025406
73V:V:L203 5.02448
74V:V:E206 5.875407
75V:V:Y208 10.612546
76V:V:H210 13.19754279
77V:V:V235 3.57408
78V:V:R236 7.05754115
79V:V:Q237 7.5375449
80V:V:Y238 7.2256114
81V:V:L243 6.695407
82V:V:F244 8.95518
83V:V:F268 5.5754135
84V:V:Y272 8.968336134
85V:V:K284 5.0525408
86V:V:L305 4.6375405
87V:V:I314 5.1625405
88V:V:I317 4.9365238
89V:V:V319 4.4125448
90V:V:Y321 8.014549
91V:V:F349 6.038547
92V:V:P360 5.02591
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:T290 R:R:Y262 54.30672.5NoYes066
2R:R:T290 R:R:Y45 54.85992.5NoYes068
3R:R:Y45 R:R:Y93 14.52086.95YesNo086
4R:R:F294 R:R:Y45 74.63958.25YesYes678
5R:R:F84 R:R:I60 10.41132.51NoYes077
6R:R:A80 R:R:I60 15.86313.25NoYes087
7R:R:A80 R:R:N56 18.29193.13NoNo089
8R:R:D83 R:R:N56 18.89526.73NoNo099
9R:R:D83 R:R:N120 18.56016.73NoYes698
10R:R:F86 R:R:N120 78.053212.08YesYes678
11R:R:F294 R:R:F86 77.405617.15YesYes677
12R:R:I131 R:R:W75 28.86865.87NoYes087
13R:R:I158 R:R:W75 1005.87NoYes177
14R:R:I158 R:R:N78 49.900715.58NoNo179
15R:R:N78 R:R:W162 49.66397.91NoYes199
16R:R:A82 R:R:W162 97.35363.89NoYes089
17R:R:A82 R:R:N120 96.84013.13NoYes088
18R:R:F127 R:R:I158 49.90075.02YesNo177
19R:R:F127 R:R:W162 49.73926.01YesYes179
20R:R:H244 R:R:I248 26.59833.98YesNo177
21R:R:I131 R:R:I248 30.23244.42NoNo087
22R:R:R149 R:R:V71 36.34316.54YesYes176
23R:R:V71 R:R:W75 36.09093.68YesYes167
24R:R:D134 R:R:R149 35.934416.68NoYes087
25R:R:D134 R:R:W75 35.91735.58NoYes087
26R:R:W103 R:R:Y96 12.80477.72YesNo096
27R:R:Y93 R:R:Y96 13.94895.96NoNo066
28R:R:F191 R:R:H203 15.76915.84YesNo054
29R:R:H203 R:R:T207 16.34094.11NoNo045
30R:R:K210 R:R:T207 16.91324.5NoNo065
31R:R:K210 R:R:S266 22.68833.06NoNo065
32R:R:S266 R:R:Y262 23.2643.82NoYes056
33R:R:W259 R:R:Y262 11.78276.75YesYes086
34R:R:H138 R:R:R149 71.17136.77YesYes187
35R:R:H138 V:V:Y63 26.3426.53YesNo189
36R:R:H138 V:V:F75 44.99854.53YesYes189
37R:R:H244 V:V:F75 27.447510.18YesYes179
38V:V:G64 V:V:I140 71.52573.53NoYes099
39V:V:F75 V:V:G64 71.68256.02YesNo099
40V:V:F61 V:V:L243 31.318813.4YesYes097
41V:V:L243 V:V:Y63 27.59784.69YesNo079
42V:V:L287 V:V:V251 11.19252.98NoNo076
43V:V:L287 V:V:Q130 15.22515.32NoYes079
44V:V:P131 V:V:Q130 16.32283.16YesYes089
45V:V:P131 V:V:R65 67.75274.32YesYes087
46V:V:I140 V:V:R65 69.22637.52YesYes097
47R:R:H263 R:R:Y262 14.70272.18NoYes086
48V:V:P124 V:V:V142 11.37055.3NoNo099
49V:V:I317 V:V:V142 11.53844.61YesNo089
50V:V:F61 V:V:I317 30.43746.28YesYes2398
51R:R:?1357 V:V:K11 29.11679.59YesNo769
52R:R:?1360 V:V:K11 15.311812.74YesNo769
53R:R:?1360 V:V:R25 38.0755.99YesYes769
54V:V:L293 V:V:R25 53.59917.29NoYes089
55V:V:H362 V:V:L293 53.86257.71NoNo018
56V:V:E169 V:V:H362 62.968818.46YesNo091
57V:V:E169 V:V:G291 62.81194.91YesNo099
58V:V:G291 V:V:T128 63.03933.64NoNo096
59V:V:K292 V:V:T128 63.5076.01NoNo066
60V:V:K292 V:V:P131 63.98393.35NoYes068
61V:V:K11 V:V:L166 14.41674.23NoYes798
62V:V:L166 V:V:R25 15.00176.07YesYes789
63R:R:?1357 V:V:R165 19.68186.2YesYes065
64R:R:?1362 R:R:A1361 18.85262.68YesNo047
65R:R:?1360 R:R:A1361 19.17132.59YesNo067
66R:R:?1362 R:R:?1363 11.583317.02YesYes247
67V:V:P14 V:V:S13 11.83013.56YesYes068
68V:V:D26 V:V:H362 10.360316.39NoNo091
69V:V:K147 V:V:R165 12.17546.19NoYes075
70V:V:F149 V:V:K147 10.91986.2YesNo2157
71V:V:I317 V:V:V127 22.96656.14YesNo088
72V:V:V127 V:V:V319 22.75093.21NoYes088
73V:V:V319 V:V:Y321 21.30965.05YesYes489
74V:V:F349 V:V:Y321 24.34778.25YesYes479
75V:V:F349 V:V:V323 16.40765.24YesNo477
76V:V:V235 V:V:V323 16.67183.21YesNo087
77V:V:L274 V:V:V235 15.7594.47NoYes058
78V:V:E256 V:V:L274 15.49915.3NoNo045
79V:V:E256 V:V:Y272 15.23897.86NoYes044
80V:V:L199 V:V:V325 10.38154.47YesNo068
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9UYN
Class A
SubFamily Protein
Type Chemerin
SubType CML2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Arrestin2
PDB Resolution 2.9
Date 2025-11-19
D.O.I. 10.1126/science.adt8794
Net Summary
Imin 3.13
Number of Linked Nodes 606
Number of Links 690
Number of Hubs 92
Number of Links mediated by Hubs 357
Number of Communities 27
Number of Nodes involved in Communities 145
Number of Links involved in Communities 182
Path Summary
Number Of Nodes in MetaPath 81
Number Of Links MetaPath 80
Number of Shortest Paths 663298
Length Of Smallest Path 3
Average Path Length 27.4307
Length of Longest Path 49
Minimum Path Strength 1.38
Average Path Strength 6.5417
Maximum Path Strength 18.52
Minimum Path Correlation 0.7
Average Path Correlation 0.964432
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 39.7088
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.6952
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeSEP
PDB ResiduesR:R:?1357 R:R:?1362 R:R:?1363 R:R:?1364
Environment DetailsOpen EMBL-EBI Page
CodeSEP
NameDexfosfoserine
SynonymsPHOSPHONOSERINE
Identifier
FormulaC3 H8 N O6 P
Molecular Weight185.072
SMILES
PubChem57689797
Formal Charge0
Total Atoms19
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0

CodeTPO
PDB ResiduesR:R:?1359 R:R:?1360
Environment DetailsOpen EMBL-EBI Page
CodeTPO
NamePHOSPHOTHREONINE
SynonymsPHOSPHONOTHREONINE
Identifier
FormulaC4 H10 N O6 P
Molecular Weight199.099
SMILES
PubChem139055008
Formal Charge0
Total Atoms22
Total Chiral Atoms2
Total Bonds21
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP46091
Sequence
>9UYN_Chain_R
VVHWVSLVL YCLAFVLGI PGNAIVIWF TGFKWKKTV TTLWFLNLA 
IADFIFLLF LPLYISYVA MNFHWPFGI WLCKANSFT AQLNMFASV 
FFLTVISLD HYIHLIHPL SHRHRTLKN SLIVIIFIW LLASLIGGP 
ALYFRDTVE FNNHTLCYN NFQKHDPDL TLIRHHVLT WVKFIIGYL 
FPLLTMSIC YLCLIFKVK KRSILISSR HFWTILVVV VAFVVCWTP 
YHLFSIWEL TIHHNSYSH HVMQAGIPL STGLAFLNS CLNPILYVL 
ISKKFQARF RSC?C??A? ??LAK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainV
ProteinArrestin
UniProtP49407
Sequence
>9UYN_Chain_V
TRVFKKASP NGKLTVYLG KRDFVDHID LVDPVDGVV LVDPEYLKE 
RRVYVTLTA FRYGREDLD VLGLTFRKD LFVANVQSF PPKPLTRLQ 
ERLIKKLGE HAYPFTFEI PPNLPSVTL QPGPEDTGK AGVDYEVKA 
FAENLEEKI HKRNSVRLV IKVQYAPER PGPQPTAET TRQPLHLEA 
SLDKEIYYH GEPISVNVH VTNNTNKTV KKIKISVRQ YADILFNTA 
QKPVAMEEA DDTVAPSST FKVYTLTPF LANNREKRG LALDGKLKH 
EDTNLASST LLREGANRE ILGIIVSYK VKVKLVVSD VAVELPFTL 
MHPKPKEEP PHREVPENA SIVEVCVS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JJPAProteinChemerinCML2Homo sapiensChemerin-9-Gi1/β1/γ22.92024-08-21doi.org/10.1371/journal.pbio.3002838
8JJP (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-2.92024-08-21doi.org/10.1371/journal.pbio.3002838
8XGMAProteinChemerinCML2Homo sapiensChemerin-Gi1/β1/γ23.292024-08-21doi.org/10.1371/journal.pbio.3002838
8XGM (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-3.292024-08-21doi.org/10.1371/journal.pbio.3002838
9L3YAProteinChemerinCML2Homo sapiensChemerin-Gi1/β1/γ23.62025-03-12doi.org/10.1093/procel/pwae073
9L3Y (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-3.62025-03-12doi.org/10.1093/procel/pwae073
9UYHAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.32025-11-1910.1126/science.adt8794
9UYH (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.32025-11-1910.1126/science.adt8794
9UYIAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.22025-11-1910.1126/science.adt8794
9UYI (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.22025-11-1910.1126/science.adt8794
9UYJAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.32025-11-1910.1126/science.adt8794
9UYJ (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.32025-11-1910.1126/science.adt8794
9UYLAProteinChemerinCML2Homo sapiensChemerin-9-Arrestin23.32025-11-1910.1126/science.adt8794
9UYL (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.32025-11-1910.1126/science.adt8794
9UYMAProteinChemerinCML2Homo sapiensChemerin-9-chim(Arrestin3-CtArrestin2)3.52025-11-1910.1126/science.adt8794
9UYM (No Gprot) AProteinChemerinCML2Homo sapiensChemerin-9-3.52025-11-1910.1126/science.adt8794
9UYNAProteinChemerinCML2Homo sapiens--Arrestin22.92025-11-1910.1126/science.adt8794
9UYN (No Gprot) AProteinChemerinCML2Homo sapiens--2.92025-11-1910.1126/science.adt8794




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9UYN.zip



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