psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S147	R:R:Y277	3.82	No	Yes	0	3	1
2	L:L:F148	L:L:F150	7.5	No	Yes	3	1	4
3	L:L:F148	R:R:Y277	8.25	No	Yes	3	1	1
4	L:L:Y149	R:R:Q192	7.89	No	No	0	5	4
5	L:L:F150	R:R:Y277	8.25	Yes	Yes	3	4	1
6	L:L:F150	R:R:H280	10.18	Yes	No	0	4	3
7	L:L:G152	L:L:P151	2.03	No	Yes	3	9	9
8	L:L:P151	L:L:Q153	3.16	Yes	Yes	3	9	6
9	L:L:P151	R:R:L186	3.28	Yes	Yes	3	9	3
10	L:L:P151	R:R:Y188	6.95	Yes	Yes	3	9	3
11	L:L:G152	L:L:Q153	3.29	No	Yes	3	9	6
12	L:L:G152	R:R:E269	4.91	No	No	0	9	4
13	L:L:Q153	R:R:L186	2.66	Yes	Yes	3	6	3
14	L:L:Q153	R:R:Y188	6.76	Yes	Yes	3	6	3
15	L:L:Q153	R:R:N189	14.52	Yes	No	3	6	4
16	L:L:Q153	R:R:F191	5.86	Yes	Yes	3	6	5
17	L:L:F154	R:R:F101	3.22	Yes	No	0	6	4
18	L:L:F154	R:R:L186	2.44	Yes	Yes	0	6	3
19	L:L:F154	R:R:Q283	9.37	Yes	No	0	6	3
20	L:L:F154	R:R:I286	2.51	Yes	Yes	0	6	4
21	L:L:A155	R:R:Y262	5.34	No	Yes	2	9	6
22	L:L:A155	R:R:I286	1.62	No	Yes	2	9	4
23	L:L:A155	R:R:T290	1.68	No	Yes	2	9	6
24	L:L:F156	R:R:Y93	6.19	Yes	Yes	2	9	6
25	L:L:F156	R:R:A117	5.55	Yes	No	0	9	6
26	L:L:F156	R:R:M121	2.49	Yes	Yes	0	9	7
27	L:L:F156	R:R:T290	2.59	Yes	Yes	2	9	6
28	L:L:S157	R:R:S114	3.26	No	No	0	5	5
29	L:L:S157	R:R:Q118	2.89	No	No	0	5	5
30	L:L:S157	R:R:K210	4.59	No	No	0	5	6
31	R:R:A284	R:R:V37	1.7	No	No	0	2	3
32	R:R:H38	R:R:W39	10.58	No	No	0	5	3
33	R:R:S41	R:R:V40	1.62	No	No	0	5	6
34	R:R:P287	R:R:S41	3.56	Yes	No	0	4	5
35	R:R:C46	R:R:L42	3.17	No	No	0	5	5
36	R:R:A98	R:R:L42	6.3	No	No	0	4	5
37	R:R:L288	R:R:L44	5.54	No	No	0	5	5
38	R:R:G291	R:R:L44	1.71	No	No	0	4	5
39	R:R:A48	R:R:Y45	6.67	No	Yes	0	6	8
40	R:R:F49	R:R:Y45	14.44	Yes	Yes	2	7	8
41	R:R:L87	R:R:Y45	7.03	Yes	Yes	2	6	8
42	R:R:L90	R:R:Y45	14.07	Yes	Yes	2	7	8
43	R:R:I94	R:R:Y45	9.67	No	Yes	0	6	8
44	R:R:F294	R:R:Y45	24.76	Yes	Yes	2	7	8
45	R:R:A48	R:R:C298	1.81	No	No	0	6	7
46	R:R:F49	R:R:I53	17.58	Yes	No	0	7	6
47	R:R:F49	R:R:L87	10.96	Yes	Yes	2	7	6
48	R:R:F49	R:R:L90	2.44	Yes	Yes	2	7	7
49	R:R:F49	R:R:P91	11.56	Yes	No	2	7	9
50	R:R:G52	R:R:L51	1.71	Yes	No	2	8	5
51	R:R:C298	R:R:L51	9.52	No	No	2	7	5
52	R:R:G52	R:R:N56	1.7	Yes	Yes	2	8	9
53	R:R:G52	R:R:L87	1.71	Yes	Yes	2	8	6
54	R:R:C298	R:R:G52	1.96	No	Yes	2	7	8
55	R:R:I53	R:R:P54	6.77	No	No	0	6	4
56	R:R:G55	R:R:P54	2.03	No	No	0	7	4
57	R:R:G55	R:R:I58	3.53	No	No	0	7	6
58	R:R:G55	R:R:P301	2.03	No	Yes	0	7	9
59	R:R:D83	R:R:N56	6.73	Yes	Yes	2	9	9
60	R:R:L87	R:R:N56	2.75	Yes	Yes	2	6	9
61	R:R:N56	R:R:P301	8.15	Yes	Yes	0	9	9
62	R:R:A80	R:R:V59	1.7	No	No	0	8	8
63	R:R:P301	R:R:V59	1.77	Yes	No	0	9	8
64	R:R:V305	R:R:V59	6.41	No	No	0	6	8
65	R:R:A80	R:R:I60	1.62	No	No	0	8	7
66	R:R:F62	R:R:W61	11.02	No	No	0	7	4
67	R:R:G64	R:R:T63	3.64	No	No	0	3	7
68	R:R:L77	R:R:T63	10.32	No	No	0	6	7
69	R:R:F65	R:R:K68	6.2	No	No	0	4	7
70	R:R:F311	R:R:K66	6.2	No	No	0	8	5
71	R:R:T70	R:R:W67	2.43	No	No	0	7	6
72	R:R:T70	R:R:T72	3.14	No	No	0	7	7
73	R:R:T70	R:R:T73	6.28	No	No	0	7	8
74	R:R:R149	R:R:V71	7.85	No	No	0	7	6
75	R:R:S154	R:R:V71	4.85	No	No	0	7	6
76	R:R:F76	R:R:T72	3.89	No	No	0	8	7
77	R:R:I158	R:R:L74	2.85	Yes	No	0	7	6
78	R:R:V130	R:R:W75	4.9	No	Yes	0	6	7
79	R:R:I131	R:R:W75	4.7	No	Yes	0	8	7
80	R:R:D134	R:R:W75	8.93	No	Yes	0	8	7
81	R:R:S154	R:R:W75	2.47	No	Yes	0	7	7
82	R:R:V157	R:R:W75	3.68	No	Yes	0	6	7
83	R:R:I158	R:R:W75	4.7	Yes	Yes	0	7	7
84	R:R:F76	R:R:Y304	3.09	No	Yes	0	8	9
85	R:R:F76	R:R:V305	9.18	No	No	0	8	6
86	R:R:I81	R:R:L77	2.85	No	No	0	5	6
87	R:R:I81	R:R:N78	2.83	No	Yes	0	5	9
88	R:R:F127	R:R:N78	13.29	Yes	Yes	2	7	9
89	R:R:I158	R:R:N78	5.66	Yes	Yes	2	7	9
90	R:R:N78	R:R:W162	13.56	Yes	Yes	2	9	9
91	R:R:D83	R:R:L79	4.07	Yes	Yes	2	9	9
92	R:R:F127	R:R:L79	4.87	Yes	Yes	2	7	9
93	R:R:L128	R:R:L79	2.77	No	Yes	0	9	9
94	R:R:L79	R:R:N300	2.75	Yes	Yes	2	9	9
95	R:R:A123	R:R:A82	1.79	No	No	0	6	8
96	R:R:D83	R:R:S124	5.89	Yes	No	0	9	9
97	R:R:D83	R:R:N300	6.73	Yes	Yes	2	9	9
98	R:R:F84	R:R:L88	2.44	No	No	0	7	5
99	R:R:I85	R:R:N120	8.5	No	No	0	6	8
100	R:R:F86	R:R:L87	3.65	Yes	Yes	2	7	6
101	R:R:F86	R:R:N120	4.83	Yes	No	0	7	8
102	R:R:F86	R:R:M121	2.49	Yes	Yes	0	7	7
103	R:R:F294	R:R:F86	4.29	Yes	Yes	2	7	7
104	R:R:F86	R:R:S297	5.28	Yes	No	2	7	8
105	R:R:L87	R:R:L90	11.07	Yes	Yes	2	6	7
106	R:R:L87	R:R:S297	3	Yes	No	2	6	8
107	R:R:F89	R:R:L88	2.44	Yes	No	0	6	5
108	R:R:F89	R:R:L92	4.87	Yes	No	0	6	6
109	R:R:F89	R:R:N113	12.08	Yes	No	0	6	5
110	R:R:F89	R:R:T116	9.08	Yes	No	0	6	5
111	R:R:L90	R:R:P91	1.64	Yes	No	2	7	9
112	R:R:F294	R:R:L90	14.61	Yes	Yes	2	7	7
113	R:R:L92	R:R:P91	1.64	No	No	0	6	9
114	R:R:F105	R:R:L92	3.65	Yes	No	0	7	6
115	R:R:V97	R:R:Y93	8.83	No	Yes	0	5	6
116	R:R:T290	R:R:Y93	3.75	Yes	Yes	2	6	6
117	R:R:F294	R:R:Y93	4.13	Yes	Yes	2	7	6
118	R:R:F105	R:R:S95	2.64	Yes	No	0	7	4
119	R:R:F101	R:R:Y96	23.73	No	No	0	4	6
120	R:R:W103	R:R:Y96	6.75	Yes	No	0	9	6
121	R:R:L186	R:R:Y96	3.52	Yes	No	0	3	6
122	R:R:F101	R:R:V97	7.87	No	No	0	4	5
123	R:R:P287	R:R:V97	1.77	Yes	No	0	4	5
124	R:R:M99	R:R:N100	14.02	No	No	10	4	3
125	R:R:H102	R:R:M99	5.25	Yes	No	10	5	4
126	R:R:H102	R:R:N100	5.1	Yes	No	10	5	3
127	R:R:H102	R:R:P104	12.2	Yes	No	0	5	3
128	R:R:H102	R:R:N183	5.1	Yes	No	0	5	5
129	R:R:F105	R:R:W103	18.04	Yes	Yes	3	7	9
130	R:R:L109	R:R:W103	3.42	No	Yes	3	5	9
131	R:R:C110	R:R:W103	10.45	No	Yes	3	9	9
132	R:R:N113	R:R:W103	3.39	No	Yes	0	5	9
133	R:R:C187	R:R:W103	3.92	No	Yes	3	9	9
134	R:R:F105	R:R:P104	5.78	Yes	No	0	7	3
135	R:R:F105	R:R:L109	2.44	Yes	No	3	7	5
136	R:R:I107	R:R:T178	3.04	No	No	0	4	5
137	R:R:C110	R:R:R176	12.54	No	Yes	3	9	4
138	R:R:C110	R:R:C187	7.28	No	No	3	9	9
139	R:R:K111	R:R:L173	2.82	No	Yes	0	7	4
140	R:R:K111	R:R:R176	7.43	No	Yes	0	7	4
141	R:R:L173	R:R:S114	4.5	Yes	No	0	4	5
142	R:R:R176	R:R:S114	11.86	Yes	No	0	4	5
143	R:R:F115	R:R:L119	3.65	No	No	0	6	5
144	R:R:F115	R:R:G169	3.01	No	No	0	6	7
145	R:R:F115	R:R:L173	12.18	No	Yes	0	6	4
146	R:R:F122	R:R:Q118	10.54	Yes	No	0	6	5
147	R:R:G169	R:R:Q118	4.93	No	No	0	7	5
148	R:R:L119	R:R:W162	4.56	No	Yes	0	5	9
149	R:R:F122	R:R:M121	4.98	Yes	Yes	0	6	7
150	R:R:M121	R:R:W259	8.14	Yes	Yes	0	7	8
151	R:R:F122	R:R:I168	5.02	Yes	No	0	6	5
152	R:R:F122	R:R:K210	6.2	Yes	No	0	6	6
153	R:R:F122	R:R:I213	10.05	Yes	No	0	6	4
154	R:R:A123	R:R:F127	2.77	No	Yes	2	6	7
155	R:R:A123	R:R:W162	2.59	No	Yes	2	6	9
156	R:R:P218	R:R:V125	3.53	Yes	No	4	9	7
157	R:R:F255	R:R:V125	6.55	Yes	No	4	9	7
158	R:R:V125	R:R:W259	4.9	No	Yes	4	7	8
159	R:R:F126	R:R:T129	2.59	Yes	Yes	0	5	7
160	R:R:F126	R:R:I161	6.28	Yes	No	0	5	7
161	R:R:F126	R:R:L164	3.65	Yes	No	0	5	4
162	R:R:F126	R:R:I213	3.77	Yes	No	0	5	4
163	R:R:F127	R:R:V130	2.62	Yes	No	0	7	6
164	R:R:F127	R:R:I161	5.02	Yes	No	0	7	7
165	R:R:F127	R:R:W162	4.01	Yes	Yes	2	7	9
166	R:R:F255	R:R:L128	2.44	Yes	No	0	9	9
167	R:R:L128	R:R:Y304	5.86	No	Yes	0	9	9
168	R:R:P218	R:R:T129	1.75	Yes	Yes	4	9	7
169	R:R:M222	R:R:T129	3.01	No	Yes	4	8	7
170	R:R:C225	R:R:S132	1.72	No	No	0	6	9
171	R:R:D134	R:R:R149	13.1	No	No	0	8	7
172	R:R:I140	R:R:Y136	8.46	Yes	No	0	7	7
173	R:R:C225	R:R:Y136	2.69	No	No	0	6	7
174	R:R:C228	R:R:Y136	2.69	No	No	0	4	7
175	R:R:H138	R:R:R149	6.77	No	No	0	8	7
176	R:R:L139	R:R:L229	5.54	No	No	0	8	7
177	R:R:H141	R:R:I140	6.63	No	Yes	0	6	7
178	R:R:I140	R:R:L229	4.28	Yes	No	0	7	7
179	R:R:I140	R:R:K232	7.27	Yes	No	0	7	5
180	R:R:H141	R:R:L144	2.57	No	No	0	6	5
181	R:R:P142	R:R:S145	1.78	Yes	No	0	8	6
182	R:R:P142	V:V:Y63	5.56	Yes	Yes	1	8	9
183	R:R:P142	V:V:L243	1.64	Yes	Yes	1	8	7
184	R:R:P142	V:V:F244	2.89	Yes	Yes	1	8	8
185	R:R:V143	V:V:I241	3.07	No	Yes	1	5	8
186	R:R:V143	V:V:Y249	6.31	No	Yes	1	5	7
187	R:R:L144	V:V:Y249	5.86	No	Yes	0	5	7
188	R:R:H146	V:V:P131	3.05	No	No	0	5	8
189	R:R:H146	V:V:I140	9.28	No	Yes	0	5	9
190	R:R:H146	V:V:R285	7.9	No	No	0	5	7
191	R:R:H148	R:R:R147	2.26	No	No	0	3	5
192	R:R:R147	V:V:Y249	6.17	No	Yes	0	5	7
193	R:R:R147	V:V:V251	3.92	No	No	0	5	6
194	R:R:N153	R:R:T150	10.24	No	No	0	4	6
195	R:R:T150	V:V:R285	5.17	No	No	0	6	7
196	R:R:K152	R:R:N153	2.8	No	No	0	5	4
197	R:R:I158	R:R:W162	2.35	Yes	Yes	2	7	9
198	R:R:I159	R:R:L163	2.85	No	No	0	3	4
199	R:R:I168	R:R:L167	2.85	No	No	0	5	4
200	R:R:G169	R:R:G170	2.11	No	No	0	7	4
201	R:R:G170	R:R:P171	4.06	No	No	0	4	8
202	R:R:F175	R:R:N190	4.83	No	No	11	4	3
203	R:R:F175	R:R:H194	3.39	No	Yes	11	4	3
204	R:R:C187	R:R:R176	12.54	No	Yes	3	9	4
205	R:R:N189	R:R:R176	2.41	No	Yes	3	4	4
206	R:R:T178	R:R:T185	6.28	No	No	0	5	4
207	R:R:F181	R:R:V179	7.87	No	No	0	4	1
208	R:R:V179	R:R:Y188	6.31	No	Yes	0	1	3
209	R:R:E180	R:R:T185	4.23	No	No	0	1	4
210	R:R:H184	R:R:N182	2.55	No	No	0	3	3
211	R:R:F191	R:R:Y188	4.13	Yes	Yes	3	5	3
212	R:R:Q192	R:R:Y188	7.89	No	Yes	0	4	3
213	R:R:F191	R:R:N189	2.42	Yes	No	3	5	4
214	R:R:H194	R:R:N190	19.13	Yes	No	11	3	3
215	R:R:E269	R:R:F191	7	No	Yes	0	4	5
216	R:R:K193	R:R:Q192	5.42	No	No	0	2	4
217	R:R:K193	R:R:L200	7.05	No	No	0	2	2
218	R:R:D195	R:R:H194	16.39	No	Yes	0	2	3
219	R:R:H194	R:R:L198	10.29	Yes	No	0	3	4
220	R:R:D195	R:R:P196	8.05	No	No	0	2	1
221	R:R:L198	R:R:R202	8.5	No	No	0	4	1
222	R:R:I201	R:R:T199	3.04	No	No	0	1	6
223	R:R:L206	R:R:R202	2.43	No	No	0	5	1
224	R:R:H203	R:R:H204	11.94	No	No	0	4	4
225	R:R:H203	R:R:H273	21.5	No	No	0	4	3
226	R:R:H204	R:R:W208	7.41	No	Yes	7	4	4
227	R:R:H204	R:R:L270	11.57	No	No	7	4	5
228	R:R:L206	R:R:T207	2.95	No	No	0	5	5
229	R:R:S266	R:R:T207	4.8	No	No	0	5	5
230	R:R:L270	R:R:T207	10.32	No	No	0	5	5
231	R:R:F211	R:R:W208	6.01	Yes	Yes	7	6	4
232	R:R:I267	R:R:W208	3.52	No	Yes	7	5	4
233	R:R:L270	R:R:W208	3.42	No	Yes	7	5	4
234	R:R:K210	R:R:Y262	3.58	No	Yes	0	6	6
235	R:R:F211	R:R:Y215	13.41	Yes	No	0	6	8
236	R:R:F211	R:R:H263	3.39	Yes	No	0	6	8
237	R:R:F211	R:R:I267	5.02	Yes	No	7	6	5
238	R:R:I212	R:R:L216	8.56	No	No	0	5	4
239	R:R:F217	R:R:I212	2.51	No	No	0	6	5
240	R:R:F217	R:R:I213	2.51	No	No	0	6	4
241	R:R:G214	R:R:P218	4.06	No	Yes	0	5	9
242	R:R:G214	R:R:H263	4.77	No	No	0	5	8
243	R:R:L219	R:R:Y215	8.21	No	No	0	6	8
244	R:R:T260	R:R:Y215	4.99	No	No	0	5	8
245	R:R:M222	R:R:P218	1.68	No	Yes	4	8	9
246	R:R:F255	R:R:P218	4.33	Yes	Yes	4	9	9
247	R:R:L219	R:R:S223	6.01	No	No	0	6	3
248	R:R:L219	R:R:V256	4.47	No	No	0	6	5
249	R:R:I224	R:R:L220	4.28	No	No	0	4	4
250	R:R:F255	R:R:M222	14.93	Yes	No	4	9	8
251	R:R:C225	R:R:I224	1.64	No	No	0	6	4
252	R:R:L227	R:R:Y226	2.34	No	Yes	0	3	9
253	R:R:I230	R:R:Y226	7.25	No	Yes	9	4	9
254	R:R:I248	R:R:Y226	6.04	Yes	Yes	9	7	9
255	R:R:L249	R:R:Y226	3.52	No	Yes	0	4	9
256	R:R:F231	R:R:L227	6.09	No	No	0	3	3
257	R:R:C228	R:R:F231	5.59	No	No	0	4	3
258	R:R:F245	R:R:I230	2.51	Yes	No	9	6	4
259	R:R:I230	R:R:I248	2.94	No	Yes	9	4	7
260	R:R:K232	R:R:K235	10.06	No	No	0	5	4
261	R:R:I238	R:R:V233	3.07	No	No	0	4	8
262	R:R:L239	R:R:V233	5.96	No	No	0	3	8
263	R:R:K235	R:R:R236	13.61	No	No	0	4	5
264	R:R:R236	V:V:F244	19.24	No	Yes	0	5	8
265	R:R:I238	V:V:F75	6.28	No	No	0	4	9
266	R:R:F245	R:R:L239	24.36	Yes	No	0	6	3
267	R:R:S241	R:R:S242	1.63	No	No	0	7	5
268	R:R:S241	R:R:W246	7.41	No	No	0	7	6
269	R:R:R243	R:R:S242	3.95	No	No	0	7	5
270	R:R:R243	R:R:S308	5.27	No	No	0	7	8
271	R:R:H244	R:R:K309	2.62	No	No	0	7	6
272	R:R:F245	R:R:W246	8.02	Yes	No	0	6	6
273	R:R:F245	R:R:I248	3.77	Yes	Yes	9	6	7
274	R:R:I248	R:R:T247	3.04	Yes	No	0	7	7
275	R:R:V251	R:R:Y304	8.83	No	Yes	0	7	9
276	R:R:F255	R:R:W259	15.03	Yes	Yes	4	9	8
277	R:R:C258	R:R:V257	1.71	No	No	0	7	5
278	R:R:C258	R:R:L292	4.76	No	No	0	7	7
279	R:R:C258	R:R:N296	9.45	No	No	0	7	9
280	R:R:N296	R:R:W259	11.3	No	Yes	0	9	8
281	R:R:P261	R:R:T260	5.25	No	No	0	9	5
282	R:R:P261	R:R:S289	1.78	No	No	0	9	7
283	R:R:L292	R:R:P261	1.64	No	No	0	7	9
284	R:R:H263	R:R:Y262	5.44	No	Yes	0	8	6
285	R:R:T290	R:R:Y262	2.5	Yes	Yes	2	6	6
286	R:R:F265	R:R:I286	6.28	No	Yes	2	4	4
287	R:R:F265	R:R:S289	5.28	No	No	2	4	7
288	R:R:I272	R:R:W268	4.7	No	No	0	2	4
289	R:R:I272	R:R:S278	3.1	No	No	0	2	2
290	R:R:H273	R:R:H274	9.55	No	No	0	3	3
291	R:R:H279	R:R:H280	2.39	No	No	0	1	3
292	R:R:H279	R:R:V281	8.3	No	No	0	1	1
293	R:R:M282	R:R:V281	3.04	No	No	0	4	1
294	R:R:G285	R:R:P287	2.03	No	Yes	0	6	4
295	R:R:G285	R:R:L288	1.71	No	No	0	6	5
296	R:R:I286	R:R:P287	3.39	Yes	Yes	0	4	4
297	R:R:I286	R:R:S289	3.1	Yes	No	2	4	7
298	R:R:G291	R:R:T290	1.82	No	Yes	0	4	6
299	R:R:F294	R:R:G291	6.02	Yes	No	0	7	4
300	R:R:L292	R:R:L295	2.77	No	No	0	7	5
301	R:R:F294	R:R:S297	2.64	Yes	No	2	7	8
302	R:R:I302	R:R:L299	2.85	No	No	12	6	7
303	R:R:L299	R:R:L303	4.15	No	No	12	7	8
304	R:R:N300	R:R:P301	3.26	Yes	Yes	0	9	9
305	R:R:N300	R:R:Y304	6.98	Yes	Yes	0	9	9
306	R:R:I302	R:R:L303	4.28	No	No	12	6	8
307	R:R:I302	R:R:L306	2.85	No	No	0	6	6
308	R:R:L303	R:R:Y304	10.55	No	Yes	0	8	9
309	R:R:L306	R:R:V305	2.98	No	No	0	6	6
310	R:R:K309	R:R:S308	6.12	No	No	0	6	8
311	R:R:A313	R:R:K310	4.82	No	No	0	4	6
312	R:R:S1357	V:V:R165	3.95	No	No	0	6	5
313	R:R:?1359	R:R:C1358	3.91	No	No	0	4	5
314	R:R:?1359	R:R:?1360	21.46	No	Yes	0	4	6
315	R:R:?1360	R:R:A1361	2.59	Yes	No	0	6	7
316	R:R:?1360	V:V:K11	11.58	Yes	No	1	6	9
317	R:R:?1360	V:V:R25	12.97	Yes	Yes	1	6	9
318	R:R:?1360	V:V:L166	6.82	Yes	Yes	1	6	8
319	R:R:?1362	R:R:A1361	4.02	Yes	No	0	4	7
320	R:R:?1362	R:R:?1363	16.01	Yes	Yes	1	4	7
321	R:R:?1362	V:V:R7	17.56	Yes	No	1	4	4
322	R:R:?1362	V:V:F9	3.11	Yes	No	0	4	6
323	R:R:?1363	R:R:?1364	25.02	Yes	Yes	1	7	5
324	R:R:?1363	V:V:R7	13.43	Yes	No	1	7	4
325	R:R:?1363	V:V:V8	5.07	Yes	Yes	1	7	7
326	R:R:?1363	V:V:K10	6	Yes	No	1	7	9
327	R:R:?1363	V:V:Y21	5.98	Yes	Yes	1	7	8
328	R:R:?1363	V:V:K107	7.19	Yes	Yes	1	7	9
329	R:R:?1364	R:R:L1365	5.89	Yes	Yes	1	5	5
330	R:R:?1364	V:V:R7	8.26	Yes	No	1	5	4
331	R:R:?1364	V:V:K107	6	Yes	Yes	1	5	9
332	R:R:L1365	V:V:T6	16.21	Yes	No	1	5	4
333	R:R:L1365	V:V:V8	4.47	Yes	Yes	1	5	7
334	R:R:L1365	V:V:R103	7.29	Yes	Yes	1	5	6
335	R:R:L1365	V:V:L104	2.77	Yes	Yes	1	5	9
336	R:R:K1367	V:V:R103	6.19	No	Yes	0	5	6
337	V:V:R103	V:V:T6	3.88	Yes	No	1	6	4
338	V:V:V8	V:V:Y21	2.52	Yes	Yes	1	7	8
339	V:V:G23	V:V:V8	1.84	No	Yes	0	8	7
340	V:V:L104	V:V:V8	4.47	Yes	Yes	1	9	7
341	V:V:F9	V:V:R25	2.14	No	Yes	0	6	9
342	V:V:E359	V:V:F9	3.5	No	No	0	1	6
343	V:V:K10	V:V:T19	4.5	No	No	1	9	7
344	V:V:K10	V:V:Y21	16.72	No	Yes	1	9	8
345	V:V:K11	V:V:L166	7.05	No	Yes	1	9	8
346	V:V:A12	V:V:T19	1.68	No	No	0	5	7
347	V:V:P14	V:V:S13	3.56	No	No	0	6	8
348	V:V:S13	V:V:V164	1.62	No	No	0	8	8
349	V:V:P14	V:V:R161	10.09	No	No	0	6	7
350	V:V:G16	V:V:N15	5.09	No	No	5	5	8
351	V:V:K17	V:V:N15	11.19	Yes	No	5	5	8
352	V:V:N15	V:V:N162	8.17	No	No	0	8	8
353	V:V:G16	V:V:K17	1.74	No	Yes	5	5	5
354	V:V:D44	V:V:K17	12.44	No	Yes	0	8	5
355	V:V:K17	V:V:Y47	14.33	Yes	Yes	5	5	5
356	V:V:A148	V:V:L18	4.73	Yes	No	1	6	6
357	V:V:L18	V:V:V164	4.47	No	No	1	6	8
358	V:V:T19	V:V:Y21	6.24	No	Yes	1	7	8
359	V:V:V20	V:V:V41	3.21	No	No	0	6	5
360	V:V:F115	V:V:V20	2.62	Yes	No	0	9	6
361	V:V:A148	V:V:V20	1.7	Yes	No	0	6	6
362	V:V:L42	V:V:Y21	2.34	No	Yes	1	5	8
363	V:V:L104	V:V:Y21	2.34	Yes	Yes	1	9	8
364	V:V:K107	V:V:Y21	3.58	Yes	Yes	1	9	8
365	V:V:L108	V:V:Y21	5.86	Yes	Yes	1	8	8
366	V:V:G39	V:V:L22	1.71	Yes	No	1	8	8
367	V:V:F115	V:V:L22	3.65	Yes	No	1	9	8
368	V:V:L166	V:V:L22	2.77	Yes	No	1	8	8
369	V:V:G23	V:V:L100	1.71	No	No	0	8	5
370	V:V:E359	V:V:K24	6.75	No	No	0	1	7
371	V:V:L166	V:V:R25	14.58	Yes	Yes	1	8	9
372	V:V:L293	V:V:R25	7.29	Yes	Yes	1	8	9
373	V:V:D26	V:V:V171	4.38	Yes	No	1	9	6
374	V:V:D26	V:V:Y173	5.75	Yes	Yes	1	9	4
375	V:V:D26	V:V:P360	11.27	Yes	Yes	1	9	1
376	V:V:D26	V:V:H362	10.08	Yes	Yes	1	9	1
377	V:V:D35	V:V:F27	2.39	Yes	No	0	6	8
378	V:V:F27	V:V:V37	13.11	No	No	0	8	8
379	V:V:F27	V:V:I168	8.79	No	No	0	8	8
380	V:V:H30	V:V:V28	9.69	No	No	1	6	8
381	V:V:D35	V:V:V28	4.38	Yes	No	1	6	8
382	V:V:V28	V:V:Y173	6.31	No	Yes	1	8	4
383	V:V:D29	V:V:K170	17.97	No	Yes	0	9	9
384	V:V:D29	V:V:Q172	13.05	No	Yes	0	9	9
385	V:V:H30	V:V:L33	7.71	No	No	0	6	3
386	V:V:D35	V:V:H30	8.82	Yes	No	1	6	6
387	V:V:I31	V:V:L305	5.71	No	Yes	0	5	5
388	V:V:I31	V:V:R307	12.53	No	No	0	5	4
389	V:V:D32	V:V:L33	8.14	No	No	0	4	3
390	V:V:I119	V:V:V34	12.29	Yes	No	1	5	7
391	V:V:K170	V:V:V34	9.11	Yes	No	1	9	7
392	V:V:P36	V:V:T116	1.75	No	No	0	5	4
393	V:V:E118	V:V:P36	6.29	No	No	0	4	5
394	V:V:F117	V:V:V37	6.55	Yes	No	0	8	8
395	V:V:I119	V:V:V37	3.07	Yes	No	0	5	8
396	V:V:D38	V:V:G39	1.68	Yes	Yes	1	7	8
397	V:V:D38	V:V:T98	4.34	Yes	No	1	7	8
398	V:V:D38	V:V:L100	5.43	Yes	No	0	7	5
399	V:V:D38	V:V:Q101	3.92	Yes	Yes	1	7	9
400	V:V:G39	V:V:Q101	3.29	Yes	Yes	1	8	9
401	V:V:F115	V:V:G39	3.01	Yes	Yes	1	9	8
402	V:V:Q101	V:V:V40	2.87	Yes	No	1	9	8
403	V:V:L104	V:V:V40	7.45	Yes	No	1	9	8
404	V:V:P114	V:V:V40	1.77	Yes	No	1	8	8
405	V:V:L108	V:V:L42	5.54	Yes	No	1	8	5
406	V:V:D44	V:V:V43	2.92	No	No	0	8	6
407	V:V:L48	V:V:V43	4.47	No	No	0	4	6
408	V:V:V43	V:V:Y113	3.79	No	Yes	0	6	3
409	V:V:H111	V:V:P45	15.25	No	No	0	6	4
410	V:V:E46	V:V:K49	13.5	No	No	0	3	5
411	V:V:R51	V:V:Y47	8.23	No	Yes	5	6	5
412	V:V:V150	V:V:Y47	7.57	No	Yes	5	5	5
413	V:V:N162	V:V:Y47	6.98	No	Yes	0	8	5
414	V:V:F87	V:V:L48	4.87	No	No	0	4	4
415	V:V:E152	V:V:E50	2.54	No	No	0	4	4
416	V:V:R51	V:V:V150	3.92	No	No	5	6	5
417	V:V:E152	V:V:R51	4.65	No	No	0	4	6
418	V:V:R52	V:V:Y54	12.35	No	Yes	8	6	4
419	V:V:Q85	V:V:R52	3.5	Yes	No	8	9	6
420	V:V:P88	V:V:R52	4.32	Yes	No	8	9	6
421	V:V:S86	V:V:V53	3.23	No	No	0	6	7
422	V:V:Q85	V:V:Y54	9.02	Yes	Yes	8	9	4
423	V:V:F149	V:V:Y54	4.13	Yes	Yes	0	5	4
424	V:V:L154	V:V:Y54	3.52	No	Yes	0	3	4
425	V:V:S86	V:V:V55	1.62	No	Yes	0	6	8
426	V:V:F115	V:V:V55	14.42	Yes	Yes	1	9	8
427	V:V:F117	V:V:V55	3.93	Yes	Yes	1	8	8
428	V:V:A148	V:V:V55	1.7	Yes	Yes	1	6	8
429	V:V:N83	V:V:T56	8.77	No	No	0	5	7
430	V:V:F149	V:V:T56	6.49	Yes	No	0	5	7
431	V:V:F117	V:V:L57	13.4	Yes	No	0	8	7
432	V:V:I119	V:V:L57	2.85	Yes	No	0	5	7
433	V:V:A59	V:V:Y144	4	No	Yes	0	8	7
434	V:V:A60	V:V:R62	6.91	No	Yes	13	8	8
435	V:V:A60	V:V:R76	4.15	No	No	13	8	8
436	V:V:F61	V:V:Y63	3.09	Yes	Yes	1	9	9
437	V:V:F61	V:V:K77	2.48	Yes	No	1	9	9
438	V:V:F61	V:V:V142	2.62	Yes	Yes	1	9	9
439	V:V:F61	V:V:L243	8.53	Yes	Yes	1	9	7
440	V:V:F61	V:V:I317	3.77	Yes	Yes	1	9	8
441	V:V:R62	V:V:R76	9.6	Yes	No	13	8	8
442	V:V:D143	V:V:R62	8.34	No	Yes	0	7	8
443	V:V:E145	V:V:R62	6.98	No	Yes	0	7	8
444	V:V:F75	V:V:Y63	2.06	No	Yes	0	9	9
445	V:V:I140	V:V:Y63	2.42	Yes	Yes	1	9	9
446	V:V:L243	V:V:Y63	4.69	Yes	Yes	1	7	9
447	V:V:D78	V:V:R76	2.38	No	No	0	8	8
448	V:V:K77	V:V:L243	4.23	No	Yes	1	9	7
449	V:V:F244	V:V:K77	2.48	Yes	No	1	8	9
450	V:V:D78	V:V:V81	7.3	No	No	0	8	4
451	V:V:L79	V:V:P124	3.28	No	Yes	0	8	9
452	V:V:L315	V:V:L79	2.77	No	No	0	5	8
453	V:V:A82	V:V:F80	4.16	No	No	0	4	4
454	V:V:F80	V:V:P120	14.45	No	Yes	1	4	7
455	V:V:F80	V:V:L123	3.65	No	Yes	1	4	6
456	V:V:A82	V:V:F117	2.77	No	Yes	0	4	8
457	V:V:F117	V:V:V84	6.55	Yes	No	0	8	3
458	V:V:P88	V:V:Q85	14.21	Yes	Yes	8	9	9
459	V:V:P89	V:V:Q85	9.47	No	Yes	8	3	9
460	V:V:S86	V:V:Y113	3.82	No	Yes	0	6	3
461	V:V:F87	V:V:P88	7.22	No	Yes	0	4	9
462	V:V:F87	V:V:Y113	19.6	No	Yes	0	4	3
463	V:V:P88	V:V:P89	7.79	Yes	No	8	9	3
464	V:V:K95	V:V:P96	1.67	No	No	0	3	3
465	V:V:L97	V:V:Q101	5.32	No	Yes	1	4	9
466	V:V:L97	V:V:P114	4.93	No	Yes	1	4	8
467	V:V:Q101	V:V:T98	7.09	Yes	No	1	9	8
468	V:V:E102	V:V:R99	9.3	No	No	0	6	4
469	V:V:R103	V:V:R99	5.33	Yes	No	0	6	4
470	V:V:P114	V:V:Q101	7.9	Yes	Yes	1	8	9
471	V:V:L104	V:V:L108	2.77	Yes	Yes	1	9	8
472	V:V:A112	V:V:I105	1.62	No	No	0	8	4
473	V:V:I105	V:V:P114	1.69	No	Yes	0	4	8
474	V:V:K107	V:V:L108	8.46	Yes	Yes	1	9	8
475	V:V:G109	V:V:L108	1.71	No	Yes	0	9	8
476	V:V:E110	V:V:H111	12.31	No	No	0	3	6
477	V:V:H111	V:V:Y113	2.18	No	Yes	0	6	3
478	V:V:F115	V:V:F117	5.36	Yes	Yes	1	9	8
479	V:V:F115	V:V:V146	2.62	Yes	No	0	9	6
480	V:V:I119	V:V:P120	3.39	Yes	Yes	1	5	7
481	V:V:I119	V:V:L123	2.85	Yes	Yes	1	5	6
482	V:V:I119	V:V:K170	4.36	Yes	Yes	1	5	9
483	V:V:P120	V:V:P121	1.95	Yes	No	0	7	4
484	V:V:L123	V:V:P120	1.64	Yes	Yes	1	6	7
485	V:V:N122	V:V:N311	5.45	No	No	1	5	4
486	V:V:I314	V:V:N122	2.83	Yes	No	1	5	5
487	V:V:L123	V:V:P124	4.93	Yes	Yes	1	6	9
488	V:V:K170	V:V:L123	2.82	Yes	Yes	1	9	6
489	V:V:P124	V:V:V142	1.77	Yes	Yes	1	9	9
490	V:V:P124	V:V:Y144	2.78	Yes	Yes	0	9	7
491	V:V:I314	V:V:P124	5.08	Yes	Yes	1	5	9
492	V:V:G316	V:V:P124	4.06	No	Yes	1	8	9
493	V:V:Q172	V:V:S125	4.33	Yes	No	0	9	7
494	V:V:E169	V:V:S126	11.5	Yes	No	1	9	9
495	V:V:G291	V:V:S126	1.86	Yes	No	1	9	9
496	V:V:A288	V:V:V127	1.7	Yes	No	1	9	8
497	V:V:A301	V:V:V127	1.7	No	No	1	9	8
498	V:V:I317	V:V:V127	6.14	Yes	No	1	8	8
499	V:V:G141	V:V:T128	3.64	No	Yes	0	9	6
500	V:V:D143	V:V:T128	2.89	No	Yes	0	7	6
501	V:V:G291	V:V:T128	1.82	Yes	Yes	0	9	6
502	V:V:K292	V:V:T128	4.5	No	Yes	0	6	6
503	V:V:I140	V:V:L129	7.14	Yes	No	1	9	8
504	V:V:G141	V:V:L129	1.71	No	No	1	9	8
505	V:V:G286	V:V:L129	1.71	No	No	0	9	8
506	V:V:P131	V:V:Q130	3.16	No	Yes	0	8	9
507	V:V:L278	V:V:Q130	2.66	No	Yes	1	8	9
508	V:V:L287	V:V:Q130	6.65	Yes	Yes	1	7	9
509	V:V:L289	V:V:Q130	5.32	Yes	Yes	1	9	9
510	V:V:G141	V:V:I140	1.76	No	Yes	1	9	9
511	V:V:G316	V:V:V142	1.84	No	Yes	1	8	9
512	V:V:I317	V:V:V142	3.07	Yes	Yes	1	8	9
513	V:V:I168	V:V:Y144	2.42	No	Yes	0	8	7
514	V:V:K170	V:V:Y144	7.17	Yes	Yes	0	9	7
515	V:V:E145	V:V:R165	4.65	No	No	0	7	5
516	V:V:E145	V:V:V167	4.28	No	No	0	7	5
517	V:V:I168	V:V:V146	4.61	No	No	0	8	6
518	V:V:F149	V:V:K147	11.17	Yes	No	0	5	7
519	V:V:K147	V:V:S163	6.12	No	No	0	7	8
520	V:V:A148	V:V:V164	1.7	Yes	No	1	6	8
521	V:V:F149	V:V:I158	6.28	Yes	No	0	5	5
522	V:V:A151	V:V:E156	7.54	No	No	0	6	6
523	V:V:E152	V:V:E156	2.54	No	No	0	4	6
524	V:V:E155	V:V:N153	3.94	No	No	0	4	4
525	V:V:E156	V:V:N153	13.15	No	No	0	6	4
526	V:V:I158	V:V:S163	4.64	No	No	0	5	8
527	V:V:K160	V:V:R165	16.09	No	No	0	8	5
528	V:V:E169	V:V:V171	4.28	Yes	No	1	9	6
529	V:V:E169	V:V:G291	4.91	Yes	Yes	1	9	9
530	V:V:E169	V:V:L293	3.98	Yes	Yes	1	9	8
531	V:V:E169	V:V:H362	17.23	Yes	Yes	1	9	1
532	V:V:V171	V:V:Y173	5.05	No	Yes	1	6	4
533	V:V:L305	V:V:Q172	5.32	Yes	Yes	0	5	9
534	V:V:H353	V:V:Y173	2.18	Yes	Yes	1	8	4
535	V:V:P356	V:V:Y173	15.3	No	Yes	1	9	4
536	V:V:P360	V:V:Y173	2.78	Yes	Yes	1	1	4
537	V:V:A174	V:V:P175	1.87	No	No	1	9	9
538	V:V:A174	V:V:I207	3.25	No	Yes	1	9	5
539	V:V:I207	V:V:P175	1.69	Yes	No	1	5	9
540	V:V:L305	V:V:P175	1.64	Yes	No	0	5	9
541	V:V:P178	V:V:R177	4.32	No	No	0	4	3
542	V:V:G179	V:V:P180	4.06	No	No	0	6	4
543	V:V:E206	V:V:G179	3.27	No	No	0	7	6
544	V:V:L203	V:V:P182	13.14	Yes	Yes	1	8	9
545	V:V:E206	V:V:P182	4.72	No	Yes	0	7	9
546	V:V:L347	V:V:P182	3.28	Yes	Yes	1	6	9
547	V:V:A184	V:V:V345	3.39	No	Yes	1	5	7
548	V:V:A184	V:V:L347	3.15	No	Yes	1	5	6
549	V:V:E185	V:V:T187	2.82	No	No	0	5	5
550	V:V:E185	V:V:H198	17.23	No	No	0	5	6
551	V:V:E185	V:V:E200	2.54	No	No	0	5	7
552	V:V:T186	V:V:V345	4.76	No	Yes	0	7	7
553	V:V:K195	V:V:T187	4.5	Yes	No	0	7	5
554	V:V:R188	V:V:V343	3.92	No	No	0	8	7
555	V:V:P196	V:V:Q189	11.05	No	No	0	6	6
556	V:V:D194	V:V:N223	5.39	No	No	0	6	6
557	V:V:K195	V:V:P196	6.69	Yes	No	0	7	6
558	V:V:H198	V:V:K195	13.1	No	Yes	0	6	7
559	V:V:K195	V:V:N223	5.6	Yes	No	0	7	6
560	V:V:L197	V:V:N222	6.87	No	No	0	7	9
561	V:V:L197	V:V:V228	2.98	No	Yes	0	7	8
562	V:V:L197	V:V:V343	7.45	No	No	0	7	7
563	V:V:H198	V:V:T221	4.11	No	No	0	6	5
564	V:V:L199	V:V:L327	4.15	No	Yes	0	6	7
565	V:V:L199	V:V:V343	2.98	No	No	0	6	7
566	V:V:L199	V:V:V345	4.47	No	Yes	0	6	7
567	V:V:A201	V:V:V325	1.7	No	Yes	1	7	8
568	V:V:A201	V:V:V345	1.7	No	Yes	1	7	7
569	V:V:A201	V:V:L347	4.73	No	Yes	1	7	6
570	V:V:N217	V:V:S202	5.96	No	No	0	6	7
571	V:V:L203	V:V:Y208	3.52	Yes	Yes	1	8	6
572	V:V:L203	V:V:V216	2.98	Yes	Yes	1	8	7
573	V:V:L203	V:V:L347	6.92	Yes	Yes	1	8	6
574	V:V:F349	V:V:L203	2.44	Yes	Yes	1	7	8
575	V:V:D204	V:V:K205	8.3	No	Yes	1	6	8
576	V:V:D204	V:V:Y208	12.64	No	Yes	1	6	6
577	V:V:D204	V:V:S215	7.36	No	No	0	6	4
578	V:V:I207	V:V:K205	2.91	Yes	Yes	1	5	8
579	V:V:K205	V:V:Y208	4.78	Yes	Yes	1	8	6
580	V:V:E212	V:V:K205	8.1	Yes	Yes	1	8	8
581	V:V:E206	V:V:T350	2.82	No	No	0	7	4
582	V:V:I207	V:V:T350	3.04	Yes	No	0	5	4
583	V:V:E212	V:V:Y208	2.24	Yes	Yes	1	8	6
584	V:V:I214	V:V:Y208	15.71	No	Yes	1	8	6
585	V:V:F349	V:V:Y208	9.28	Yes	Yes	1	7	6
586	V:V:E212	V:V:Y209	6.73	Yes	No	0	8	6
587	V:V:P354	V:V:Y209	11.13	No	No	0	8	6
588	V:V:H210	V:V:N299	12.75	Yes	No	1	9	8
589	V:V:H210	V:V:L300	2.57	Yes	Yes	1	9	9
590	V:V:H210	V:V:S302	5.58	Yes	No	0	9	9
591	V:V:H210	V:V:L351	10.29	Yes	Yes	1	9	8
592	V:V:H210	V:V:H353	13.14	Yes	Yes	1	9	8
593	V:V:G211	V:V:T275	1.82	No	No	0	8	4
594	V:V:E212	V:V:P213	4.72	Yes	No	0	8	4
595	V:V:P213	V:V:T273	1.75	No	No	0	4	3
596	V:V:P213	V:V:T275	1.75	No	No	0	4	4
597	V:V:I214	V:V:P276	5.08	No	Yes	0	8	9
598	V:V:F349	V:V:I214	2.51	Yes	No	1	7	8
599	V:V:I233	V:V:V216	3.07	Yes	Yes	1	5	7
600	V:V:V216	V:V:Y272	2.52	Yes	Yes	1	7	4
601	V:V:V216	V:V:V323	3.21	Yes	No	0	7	7
602	V:V:N217	V:V:V271	2.96	No	No	0	6	5
603	V:V:I231	V:V:V218	3.07	Yes	No	0	6	7
604	V:V:V218	V:V:Y272	6.31	No	Yes	0	7	4
605	V:V:V218	V:V:V325	4.81	No	Yes	0	7	8
606	V:V:H219	V:V:T221	2.74	No	No	14	5	5
607	V:V:H219	V:V:T267	2.74	No	No	14	5	6
608	V:V:H219	V:V:S269	6.97	No	No	0	5	5
609	V:V:L327	V:V:V220	2.98	Yes	No	0	7	6
610	V:V:T221	V:V:T267	3.14	No	No	14	5	6
611	V:V:N222	V:V:T224	5.85	No	No	0	9	9
612	V:V:N222	V:V:V262	4.43	No	Yes	0	9	7
613	V:V:K226	V:V:T227	3	No	No	0	8	5
614	V:V:K226	V:V:V329	7.59	No	No	0	8	6
615	V:V:P264	V:V:T227	3.5	No	No	0	5	5
616	V:V:V228	V:V:V262	6.41	Yes	Yes	0	8	7
617	V:V:L327	V:V:V228	4.47	Yes	Yes	0	7	8
618	V:V:V228	V:V:V329	3.21	Yes	No	0	8	6
619	V:V:E257	V:V:K230	2.7	No	No	0	6	5
620	V:V:I231	V:V:I233	2.94	Yes	Yes	0	6	5
621	V:V:A258	V:V:I231	4.87	No	Yes	0	5	6
622	V:V:I231	V:V:L327	5.71	Yes	Yes	0	6	7
623	V:V:K232	V:V:M255	2.88	No	No	15	6	3
624	V:V:E257	V:V:K232	5.4	No	No	15	6	6
625	V:V:K232	V:V:K326	7.18	No	No	0	6	7
626	V:V:I233	V:V:Y272	8.46	Yes	Yes	1	5	4
627	V:V:I233	V:V:V325	3.07	Yes	Yes	1	5	8
628	V:V:R236	V:V:S234	2.64	Yes	No	0	5	5
629	V:V:A254	V:V:V235	1.7	No	No	0	7	8
630	V:V:V235	V:V:V323	3.21	No	No	0	8	7
631	V:V:F349	V:V:V235	2.62	Yes	No	0	7	8
632	V:V:R236	V:V:Y238	11.32	Yes	Yes	6	5	4
633	V:V:K250	V:V:R236	16.09	No	Yes	6	5	5
634	V:V:K322	V:V:R236	2.48	Yes	Yes	6	5	5
635	V:V:K324	V:V:R236	11.14	No	Yes	6	6	5
636	V:V:E346	V:V:R236	6.98	Yes	Yes	6	8	5
637	V:V:Q237	V:V:V253	2.87	Yes	No	0	9	9
638	V:V:L287	V:V:Q237	7.99	Yes	Yes	1	7	9
639	V:V:A288	V:V:Q237	4.55	Yes	Yes	1	9	9
640	V:V:L300	V:V:Q237	2.66	Yes	Yes	1	9	9
641	V:V:Q237	V:V:V319	4.3	Yes	Yes	1	9	8
642	V:V:Q237	V:V:Y321	15.78	Yes	Yes	1	9	9
643	V:V:K250	V:V:Y238	8.36	No	Yes	6	5	4
644	V:V:S320	V:V:Y238	5.09	No	Yes	0	8	4
645	V:V:K322	V:V:Y238	15.53	Yes	Yes	6	5	4
646	V:V:E346	V:V:Y238	3.37	Yes	Yes	6	8	4
647	V:V:A239	V:V:I241	4.87	No	Yes	0	8	8
648	V:V:D240	V:V:Q248	7.83	No	No	0	6	6
649	V:V:D240	V:V:I318	2.8	No	No	0	6	5
650	V:V:I241	V:V:Y249	4.84	Yes	Yes	1	8	7
651	V:V:I241	V:V:I317	8.83	Yes	Yes	1	8	8
652	V:V:F244	V:V:L243	12.18	Yes	Yes	1	8	7
653	V:V:N245	V:V:T246	2.92	No	No	0	8	7
654	V:V:A247	V:V:Y249	5.34	No	Yes	0	8	7
655	V:V:P252	V:V:V251	3.53	No	No	0	4	6
656	V:V:L287	V:V:V251	2.98	Yes	No	0	7	6
657	V:V:M255	V:V:P252	3.35	No	No	0	3	4
658	V:V:P276	V:V:V253	1.77	Yes	No	0	9	9
659	V:V:N281	V:V:V253	7.39	Yes	No	0	9	9
660	V:V:E257	V:V:M255	2.71	No	No	15	6	3
661	V:V:E256	V:V:Y272	13.47	No	Yes	0	4	4
662	V:V:E256	V:V:L274	7.95	No	No	0	4	5
663	V:V:A258	V:V:Y272	4	No	Yes	0	5	4
664	V:V:D260	V:V:F268	11.94	No	No	1	6	5
665	V:V:D260	V:V:K270	4.15	No	No	1	6	8
666	V:V:D260	V:V:Y272	4.6	No	Yes	1	6	4
667	V:V:S266	V:V:V262	3.23	No	Yes	0	6	7
668	V:V:F268	V:V:V262	3.93	No	Yes	0	5	7
669	V:V:A263	V:V:P264	1.87	No	No	0	4	5
670	V:V:A263	V:V:S266	3.42	No	No	0	4	6
671	V:V:F268	V:V:K270	4.96	No	No	1	5	8
672	V:V:K270	V:V:Y272	22.69	No	Yes	1	8	4
673	V:V:P276	V:V:T275	3.5	Yes	No	0	9	4
674	V:V:L300	V:V:P276	1.64	Yes	Yes	0	9	9
675	V:V:L351	V:V:P276	1.64	Yes	Yes	0	8	9
676	V:V:A279	V:V:F277	2.77	No	No	0	4	3
677	V:V:F277	V:V:N280	13.29	No	No	0	3	4
678	V:V:L278	V:V:R282	7.29	No	No	0	8	6
679	V:V:L278	V:V:L289	5.54	No	Yes	1	8	9
680	V:V:N280	V:V:N281	8.17	No	Yes	0	4	9
681	V:V:K284	V:V:N281	9.79	No	Yes	0	8	9
682	V:V:L287	V:V:N281	2.75	Yes	Yes	0	7	9
683	V:V:D297	V:V:R282	4.76	No	No	0	8	6
684	V:V:L287	V:V:L289	4.15	Yes	Yes	1	7	9
685	V:V:L287	V:V:L300	2.77	Yes	Yes	1	7	9
686	V:V:A288	V:V:A301	1.79	Yes	No	1	9	9
687	V:V:A288	V:V:V319	1.7	Yes	Yes	1	9	8
688	V:V:K292	V:V:L289	7.05	No	Yes	1	6	9
689	V:V:L289	V:V:T298	4.42	Yes	No	1	9	8
690	V:V:D290	V:V:G291	1.68	Yes	Yes	0	9	9
691	V:V:D290	V:V:T298	2.89	Yes	No	0	9	8
692	V:V:D290	V:V:N299	6.73	Yes	No	0	9	8
693	V:V:D290	V:V:S302	5.89	Yes	No	0	9	9
694	V:V:K292	V:V:T298	10.51	No	No	1	6	8
695	V:V:K294	V:V:L293	5.64	Yes	Yes	0	9	8
696	V:V:H362	V:V:L293	7.71	Yes	Yes	1	1	8
697	V:V:E296	V:V:K294	10.8	No	Yes	0	7	9
698	V:V:K294	V:V:R363	2.48	Yes	No	0	9	1
699	V:V:H353	V:V:N299	8.93	Yes	No	1	8	8
700	V:V:A301	V:V:V319	5.09	No	Yes	1	9	8
701	V:V:S303	V:V:Y321	2.54	No	Yes	0	8	9
702	V:V:S303	V:V:T350	4.8	No	No	0	8	4
703	V:V:M352	V:V:S303	3.07	No	No	0	8	8
704	V:V:I318	V:V:T304	3.04	No	No	0	5	9
705	V:V:L305	V:V:M352	2.83	Yes	No	0	5	8
706	V:V:I314	V:V:L306	2.85	Yes	No	0	5	4
707	V:V:E308	V:V:R307	9.3	No	No	0	3	4
708	V:V:A310	V:V:G309	1.95	No	No	0	4	4
709	V:V:E313	V:V:N311	10.52	No	No	0	7	4
710	V:V:I314	V:V:N311	5.66	Yes	No	1	5	4
711	V:V:V319	V:V:Y321	5.05	Yes	Yes	1	8	9
712	V:V:F349	V:V:Y321	5.16	Yes	Yes	1	7	9
713	V:V:L351	V:V:Y321	4.69	Yes	Yes	1	8	9
714	V:V:E346	V:V:K322	8.1	Yes	Yes	6	8	5
715	V:V:K322	V:V:P348	3.35	Yes	No	0	5	9
716	V:V:L347	V:V:V323	2.98	Yes	No	0	6	7
717	V:V:A344	V:V:K324	3.21	No	No	0	4	6
718	V:V:E346	V:V:K324	17.55	Yes	No	6	8	6
719	V:V:V325	V:V:V345	3.21	Yes	Yes	1	8	7
720	V:V:K326	V:V:V328	3.04	No	No	0	7	4
721	V:V:L347	V:V:V345	2.98	Yes	Yes	1	6	7
722	V:V:L347	V:V:P348	1.64	Yes	No	0	6	9
723	V:V:F349	V:V:L351	2.44	Yes	Yes	1	7	8
724	V:V:H353	V:V:P354	4.58	Yes	No	0	8	8
725	V:V:K355	V:V:P356	3.35	No	No	0	6	9
726	V:V:P356	V:V:P360	5.84	No	Yes	1	9	1
727	V:V:E358	V:V:K357	4.05	No	No	0	1	1
728	V:V:E359	V:V:P360	3.14	No	Yes	0	1	1
729	V:V:P360	V:V:P361	1.95	Yes	No	0	1	1
730	V:V:H362	V:V:P360	6.1	Yes	Yes	1	1	1
731	V:V:P361	V:V:V365	3.53	No	No	0	1	1
732	V:V:E367	V:V:R363	8.14	No	No	0	1	1
733	V:V:P366	V:V:V365	5.3	No	No	0	1	1
734	V:V:E367	V:V:N368	2.63	No	No	0	1	1
735	V:V:D35	V:V:P36	1.61	Yes	No	0	6	5
736	R:R:V36	R:R:V37	1.6	No	No	0	3	3
737	R:R:V250	R:R:V251	1.6	No	No	0	6	7
738	R:R:V252	R:R:V256	1.6	No	No	0	7	5
739	R:R:V253	R:R:V257	1.6	No	No	0	5	5
740	V:V:S202	V:V:T183	1.6	No	No	0	7	4
741	R:R:T247	R:R:V251	1.59	No	No	0	7	7
742	V:V:T246	V:V:V242	1.59	No	No	0	7	6
743	R:R:A254	R:R:L299	1.58	No	No	0	7	7
744	V:V:P182	V:V:Q181	1.58	Yes	No	0	9	7
745	R:R:T129	R:R:T221	1.57	Yes	No	0	7	6
746	V:V:T56	V:V:T58	1.57	No	No	0	7	7
747	V:V:E364	V:V:P366	1.57	No	No	0	1	1
748	R:R:I137	R:R:S145	1.55	No	No	0	5	6
749	R:R:I307	R:R:S308	1.55	No	No	0	6	8
750	V:V:K229	V:V:V328	1.52	No	No	0	8	4
751	R:R:F65	R:R:G64	1.51	No	No	0	4	3
752	R:R:K66	R:R:T73	1.5	No	No	0	5	8
753	R:R:L119	R:R:S166	1.5	No	No	0	5	4
754	R:R:L163	R:R:S166	1.5	No	No	0	4	4
755	R:R:L167	R:R:S166	1.5	No	No	0	4	4
756	V:V:K95	V:V:T116	1.5	No	No	0	3	4
757	R:R:L151	R:R:V71	1.49	No	No	0	3	6
758	V:V:N223	V:V:S265	1.49	No	No	0	6	8
759	R:R:L264	R:R:T260	1.47	No	No	0	5	5
760	V:V:D240	V:V:T246	1.45	No	No	0	6	7
761	L:L:F150	L:L:P151	1.44	Yes	Yes	3	4	9
762	R:R:I94	R:R:L42	1.43	No	No	0	6	5
763	R:R:I137	R:R:L133	1.43	No	No	0	5	6
764	R:R:I156	R:R:N153	1.42	No	No	0	3	4
765	V:V:Q172	V:V:T304	1.42	Yes	No	0	9	9
766	V:V:E200	V:V:T183	1.41	No	No	0	7	4
767	V:V:K226	V:V:N225	1.4	No	No	0	8	5
768	R:R:L47	R:R:L51	1.38	No	No	0	4	5
769	R:R:L155	R:R:L74	1.38	No	No	0	4	6
770	V:V:D259	V:V:K230	1.38	No	No	0	3	5
771	V:V:D342	V:V:K326	1.38	No	No	0	7	7
772	R:R:D177	R:R:N190	1.35	No	No	0	5	3
773	R:R:H135	R:R:I131	1.33	No	No	0	9	8
774	R:R:H244	R:R:I240	1.33	No	No	0	7	5
775	R:R:R202	R:R:V205	1.31	No	No	0	1	3
776	V:V:H295	V:V:K294	1.31	No	Yes	0	7	9
777	R:R:V36	R:R:W39	1.23	No	No	0	3	3
778	R:R:T185	R:R:W103	1.21	No	Yes	0	4	9
779	R:R:I272	R:R:Y277	1.21	No	Yes	0	2	1
780	R:R:L173	R:R:Y174	1.17	Yes	No	0	4	5
781	R:R:F311	R:R:Q312	1.17	No	No	0	8	8
782	V:V:Q189	V:V:R188	1.17	No	No	0	6	8
783	R:R:K111	R:R:W108	1.16	No	No	0	7	1
784	V:V:E313	V:V:R312	1.16	No	No	0	7	4
785	R:R:F62	R:R:F65	1.07	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F150	6.8425	4	3	4
2	L:L:P151	3.372	5	3	9
3	L:L:Q153	6.04167	6	3	6
4	L:L:F154	4.385	4	0	6
5	L:L:F156	4.205	4	2	9
6	R:R:Y45	12.7733	6	2	8
7	R:R:F49	11.396	5	2	7
8	R:R:G52	1.77	4	2	8
9	R:R:N56	4.8325	4	2	9
10	R:R:W75	4.89667	6	0	7
11	R:R:N78	8.835	4	2	9
12	R:R:L79	3.615	4	2	9
13	R:R:D83	5.855	4	2	9
14	R:R:F86	4.108	5	2	7
15	R:R:L87	5.73857	7	2	6
16	R:R:F89	7.1175	4	0	6
17	R:R:L90	8.766	5	2	7
18	R:R:Y93	5.725	4	2	6
19	R:R:H102	6.9125	4	10	5
20	R:R:W103	6.74	7	3	9
21	R:R:F105	6.51	5	3	7
22	R:R:M121	4.525	4	0	7
23	R:R:F122	7.358	5	0	6
24	R:R:F126	4.0725	4	0	5
25	R:R:F127	5.43	6	2	7
26	R:R:T129	2.23	4	4	7
27	R:R:I140	6.66	4	0	7
28	R:R:P142	2.9675	4	1	8
29	R:R:I158	3.89	4	2	7
30	R:R:W162	5.414	5	2	9
31	R:R:L173	5.1675	4	0	4
32	R:R:R176	9.356	5	3	4
33	R:R:L186	2.975	4	3	3
34	R:R:Y188	6.408	5	3	3
35	R:R:F191	4.8525	4	3	5
36	R:R:H194	12.3	4	11	3
37	R:R:W208	5.09	4	7	4
38	R:R:F211	6.9575	4	7	6
39	R:R:P218	3.07	5	4	9
40	R:R:Y226	4.7875	4	9	9
41	R:R:F245	9.665	4	9	6
42	R:R:I248	3.9475	4	9	7
43	R:R:F255	8.656	5	4	9
44	R:R:W259	9.8425	4	4	8
45	R:R:Y262	4.215	4	2	6
46	R:R:Y277	5.3825	4	3	1
47	R:R:I286	3.38	5	2	4
48	R:R:P287	2.6875	4	0	4
49	R:R:T290	2.468	5	2	6
50	R:R:F294	9.40833	6	2	7
51	R:R:N300	4.93	4	2	9
52	R:R:P301	3.8025	4	0	9
53	R:R:Y304	7.062	5	0	9
54	R:R:?1360	11.084	5	1	6
55	R:R:?1362	10.175	4	1	4
56	R:R:?1363	11.2429	7	1	7
57	R:R:?1364	11.2925	4	1	5
58	R:R:L1365	7.326	5	1	5
59	V:V:V8	3.674	5	1	7
60	V:V:K17	9.925	4	5	5
61	V:V:Y21	5.6975	8	1	8
62	V:V:R25	9.245	4	1	9
63	V:V:D26	7.87	4	1	9
64	V:V:D35	4.3	4	1	6
65	V:V:D38	3.8425	4	1	7
66	V:V:G39	2.4225	4	1	8
67	V:V:Y47	9.2775	4	5	5
68	V:V:Y54	7.255	4	8	4
69	V:V:V55	5.4175	4	1	8
70	V:V:F61	4.098	5	1	9
71	V:V:R62	7.9575	4	13	8
72	V:V:Y63	3.564	5	1	9
73	V:V:Q85	9.05	4	8	9
74	V:V:P88	8.385	4	8	9
75	V:V:Q101	5.065	6	1	9
76	V:V:R103	5.6725	4	1	6
77	V:V:L104	3.96	5	1	9
78	V:V:K107	6.3075	4	1	9
79	V:V:L108	4.868	5	1	8
80	V:V:Y113	7.3475	4	0	3
81	V:V:P114	4.0725	4	1	8
82	V:V:F115	5.28	6	1	9
83	V:V:F117	6.42667	6	1	8
84	V:V:I119	4.80167	6	1	5
85	V:V:P120	5.3575	4	1	7
86	V:V:L123	3.178	5	1	6
87	V:V:P124	3.65	6	1	9
88	V:V:T128	3.2125	4	0	6
89	V:V:Q130	4.4475	4	1	9
90	V:V:I140	5.15	4	1	9
91	V:V:V142	2.325	4	1	9
92	V:V:Y144	4.0925	4	0	7
93	V:V:A148	2.4575	4	1	6
94	V:V:F149	7.0175	4	0	5
95	V:V:L166	7.805	4	1	8
96	V:V:E169	8.38	5	1	9
97	V:V:K170	8.286	5	1	9
98	V:V:Q172	6.03	4	0	9
99	V:V:Y173	6.22833	6	1	4
100	V:V:P182	5.68	4	1	9
101	V:V:K195	7.4725	4	0	7
102	V:V:L203	5.8	5	1	8
103	V:V:K205	6.0225	4	1	8
104	V:V:I207	2.7225	4	1	5
105	V:V:Y208	8.02833	6	1	6
106	V:V:H210	8.866	5	1	9
107	V:V:E212	5.4475	4	1	8
108	V:V:V216	2.945	4	1	7
109	V:V:V228	4.2675	4	0	8
110	V:V:I231	4.1475	4	0	6
111	V:V:I233	4.385	4	1	5
112	V:V:R236	8.44167	6	6	5
113	V:V:Q237	6.35833	6	1	9
114	V:V:Y238	8.734	5	6	4
115	V:V:I241	5.4025	4	1	8
116	V:V:L243	6.254	5	1	7
117	V:V:F244	9.1975	4	1	8
118	V:V:Y249	5.704	5	1	7
119	V:V:V262	4.5	4	0	7
120	V:V:Y272	8.86429	7	1	4
121	V:V:P276	2.726	5	0	9
122	V:V:N281	7.025	4	0	9
123	V:V:L287	4.54833	6	1	7
124	V:V:A288	2.435	4	1	9
125	V:V:L289	5.296	5	1	9
126	V:V:D290	4.2975	4	0	9
127	V:V:G291	2.5675	4	1	9
128	V:V:L293	6.155	4	1	8
129	V:V:K294	5.0575	4	0	9
130	V:V:L300	2.41	4	1	9
131	V:V:L305	3.875	4	0	5
132	V:V:I314	4.105	4	1	5
133	V:V:I317	5.4525	4	1	8
134	V:V:V319	4.035	4	1	8
135	V:V:Y321	6.644	5	1	9
136	V:V:K322	7.365	4	6	5
137	V:V:V325	3.1975	4	1	8
138	V:V:L327	4.3275	4	0	7
139	V:V:V345	3.41833	6	1	7
140	V:V:E346	9	4	6	8
141	V:V:L347	3.66857	7	1	6
142	V:V:F349	4.075	6	1	7
143	V:V:L351	4.765	4	1	8
144	V:V:H353	7.2075	4	1	8
145	V:V:P360	5.18	6	1	1
146	V:V:H362	10.28	4	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q192	R:R:Y188	12.9179	7.89	No	Yes	0	4	3
2	L:L:P151	R:R:L186	13.3922	3.28	Yes	Yes	3	9	3
3	L:L:F154	R:R:L186	14.9118	2.44	Yes	Yes	0	6	3
4	L:L:F154	R:R:I286	10.5636	2.51	Yes	Yes	0	6	4
5	L:L:A155	R:R:I286	11.1843	1.62	No	Yes	2	9	4
6	L:L:F156	R:R:Y93	11.0288	6.19	Yes	Yes	2	9	6
7	R:R:V97	R:R:Y93	12.091	8.83	No	Yes	0	5	6
8	R:R:F101	R:R:V97	11.0236	7.87	No	No	0	4	5
9	L:L:F156	R:R:M121	17.4938	2.49	Yes	Yes	0	9	7
10	R:R:N189	R:R:R176	18.4064	2.41	No	Yes	3	4	4
11	R:R:R176	R:R:S114	14.6771	11.86	Yes	No	0	4	5
12	R:R:F105	R:R:L92	10.0306	3.65	Yes	No	0	7	6
13	R:R:L92	R:R:P91	13.9883	1.64	No	No	0	6	9
14	R:R:L87	R:R:N56	24.1713	2.75	Yes	Yes	2	6	9
15	R:R:N56	R:R:P301	13.0171	8.15	Yes	Yes	0	9	9
16	R:R:D83	R:R:N56	12.9462	6.73	Yes	Yes	2	9	9
17	R:R:F115	R:R:L173	16.1816	12.18	No	Yes	0	6	4
18	R:R:F115	R:R:L119	17.3636	3.65	No	No	0	6	5
19	R:R:L119	R:R:W162	18.8178	4.56	No	Yes	0	5	9
20	R:R:M121	R:R:W259	28.1379	8.14	Yes	Yes	0	7	8
21	R:R:F255	R:R:W259	29.8474	15.03	Yes	Yes	4	9	8
22	R:R:F255	R:R:L128	43.1534	2.44	Yes	No	0	9	9
23	R:R:L128	R:R:Y304	57.7096	5.86	No	Yes	0	9	9
24	R:R:G214	R:R:H263	10.4564	4.77	No	No	0	5	8
25	R:R:G214	R:R:P218	10.5933	4.06	No	Yes	0	5	9
26	R:R:F255	R:R:P218	11.802	4.33	Yes	Yes	4	9	9
27	R:R:F127	R:R:W162	19.4721	4.01	Yes	Yes	2	7	9
28	R:R:F127	R:R:L79	30.335	4.87	Yes	Yes	2	7	9
29	R:R:L79	R:R:N300	15.0212	2.75	Yes	Yes	2	9	9
30	R:R:D83	R:R:N300	12.5531	6.73	Yes	Yes	2	9	9
31	R:R:N300	R:R:P301	13.6711	3.26	Yes	Yes	0	9	9
32	R:R:V251	R:R:Y304	99.8844	8.83	No	Yes	0	7	9
33	R:R:T247	R:R:V251	99.9618	1.59	No	No	0	7	7
34	R:R:I248	R:R:T247	100	3.04	Yes	No	0	7	7
35	R:R:F245	R:R:I248	96.4468	3.77	Yes	Yes	9	6	7
36	R:R:F245	R:R:L239	97.2672	24.36	Yes	No	0	6	3
37	R:R:L239	R:R:V233	97.2952	5.96	No	No	0	3	8
38	R:R:I238	R:R:V233	97.3248	3.07	No	No	0	4	8
39	R:R:I238	V:V:F75	97.3568	6.28	No	No	0	4	9
40	V:V:F75	V:V:Y63	97.3905	2.06	No	Yes	0	9	9
41	V:V:F61	V:V:Y63	82.7181	3.09	Yes	Yes	1	9	9
42	V:V:F61	V:V:I317	43.4757	3.77	Yes	Yes	1	9	8
43	V:V:I140	V:V:Y63	15.7652	2.42	Yes	Yes	1	9	9
44	V:V:G141	V:V:I140	11.8462	1.76	No	Yes	1	9	9
45	V:V:G141	V:V:T128	11.9888	3.64	No	Yes	0	9	6
46	V:V:G291	V:V:T128	11.0775	1.82	Yes	Yes	0	9	6
47	V:V:E169	V:V:G291	10.7579	4.91	Yes	Yes	1	9	9
48	V:V:F61	V:V:V142	40.724	2.62	Yes	Yes	1	9	9
49	V:V:P124	V:V:V142	43.5808	1.77	Yes	Yes	1	9	9
50	V:V:P124	V:V:Y144	15.9013	2.78	Yes	Yes	0	9	7
51	V:V:I168	V:V:Y144	13.5446	2.42	No	Yes	0	8	7
52	V:V:I168	V:V:V146	12.2378	4.61	No	No	0	8	6
53	V:V:F115	V:V:V146	12.0937	2.62	Yes	No	0	9	6
54	V:V:L123	V:V:P124	26.62	4.93	Yes	Yes	1	6	9
55	V:V:F117	V:V:V55	24.4724	3.93	Yes	Yes	1	8	8
56	V:V:I119	V:V:L123	15.8008	2.85	Yes	Yes	1	5	6
57	V:V:F117	V:V:V37	10.2564	6.55	Yes	No	0	8	8
58	V:V:S86	V:V:V55	28.8461	1.62	No	Yes	0	6	8
59	V:V:S86	V:V:Y113	27.6849	3.82	No	Yes	0	6	3
60	V:V:V43	V:V:Y113	10.0941	3.79	No	Yes	0	6	3
61	V:V:F87	V:V:Y113	15.4016	19.6	No	Yes	0	4	3
62	V:V:F87	V:V:P88	14.2937	7.22	No	Yes	0	4	9
63	V:V:I317	V:V:V127	44.6327	6.14	Yes	No	1	8	8
64	V:V:A288	V:V:V127	30.3174	1.7	Yes	No	1	9	8
65	V:V:A301	V:V:V127	14.2244	1.7	No	No	1	9	8
66	V:V:A288	V:V:Q237	16.2038	4.55	Yes	Yes	1	9	9
67	V:V:Q237	V:V:Y321	15.606	15.78	Yes	Yes	1	9	9
68	V:V:A288	V:V:V319	14.0686	1.7	Yes	Yes	1	9	8
69	V:V:V319	V:V:Y321	27.8668	5.05	Yes	Yes	1	8	9
70	V:V:A301	V:V:V319	14.1326	5.09	No	Yes	1	9	8
71	V:V:F349	V:V:Y321	39.8795	5.16	Yes	Yes	1	7	9
72	V:V:F349	V:V:L203	41.92	2.44	Yes	Yes	1	7	8
73	V:V:L203	V:V:L347	26.4839	6.92	Yes	Yes	1	8	6
74	V:V:L347	V:V:V345	19.1646	2.98	Yes	Yes	1	6	7
75	V:V:L199	V:V:V345	17.7991	4.47	No	Yes	0	6	7
76	V:V:L199	V:V:V343	14.0158	2.98	No	No	0	6	7
77	V:V:R188	V:V:V343	12.1978	3.92	No	No	0	8	7
78	V:V:Q189	V:V:R188	11.714	1.17	No	No	0	6	8
79	V:V:P196	V:V:Q189	11.2298	11.05	No	No	0	6	6
80	V:V:K195	V:V:P196	10.7454	6.69	Yes	No	0	7	6
81	V:V:L203	V:V:V216	14.9043	2.98	Yes	Yes	1	8	7
82	L:L:Q153	R:R:Y188	11.2935	6.76	Yes	Yes	3	6	3
83	R:R:L128	R:R:L79	15.2629	2.77	No	Yes	0	9	9
84	R:R:N300	R:R:Y304	40.971	6.98	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S147	R:R:Y277	3.82	0	No	Yes	3	1	0	1
L:L:F148	R:R:Y277	8.25	3	No	Yes	1	1	0	1
L:L:Y149	R:R:Q192	7.89	0	No	No	5	4	0	1
L:L:F150	R:R:Y277	8.25	3	Yes	Yes	4	1	0	1
L:L:F150	R:R:H280	10.18	3	Yes	No	4	3	0	1
L:L:P151	R:R:L186	3.28	3	Yes	Yes	9	3	0	1
L:L:P151	R:R:Y188	6.95	3	Yes	Yes	9	3	0	1
L:L:G152	R:R:E269	4.91	3	No	No	9	4	0	1
L:L:Q153	R:R:L186	2.66	3	Yes	Yes	6	3	0	1
L:L:Q153	R:R:Y188	6.76	3	Yes	Yes	6	3	0	1
L:L:Q153	R:R:N189	14.52	3	Yes	No	6	4	0	1
L:L:Q153	R:R:F191	5.86	3	Yes	Yes	6	5	0	1
L:L:F154	R:R:F101	3.22	0	Yes	No	6	4	0	1
L:L:F154	R:R:L186	2.44	0	Yes	Yes	6	3	0	1
L:L:F154	R:R:Q283	9.37	0	Yes	No	6	3	0	1
L:L:F154	R:R:I286	2.51	0	Yes	Yes	6	4	0	1
L:L:A155	R:R:Y262	5.34	2	No	Yes	9	6	0	1
L:L:A155	R:R:I286	1.62	2	No	Yes	9	4	0	1
L:L:A155	R:R:T290	1.68	2	No	Yes	9	6	0	1
L:L:F156	R:R:Y93	6.19	2	Yes	Yes	9	6	0	1
L:L:F156	R:R:A117	5.55	2	Yes	No	9	6	0	1
L:L:F156	R:R:M121	2.49	2	Yes	Yes	9	7	0	1
L:L:F156	R:R:T290	2.59	2	Yes	Yes	9	6	0	1
L:L:S157	R:R:S114	3.26	0	No	No	5	5	0	1
L:L:S157	R:R:Q118	2.89	0	No	No	5	5	0	1
L:L:S157	R:R:K210	4.59	0	No	No	5	6	0	1
R:R:F86	R:R:M121	2.49	2	Yes	Yes	7	7	2	1
R:R:F294	R:R:F86	4.29	2	Yes	Yes	7	7	2	2
R:R:V97	R:R:Y93	8.83	0	No	Yes	5	6	2	1
R:R:T290	R:R:Y93	3.75	2	Yes	Yes	6	6	1	1
R:R:F294	R:R:Y93	4.13	2	Yes	Yes	7	6	2	1
R:R:F101	R:R:Y96	23.73	0	No	No	4	6	1	2
R:R:L186	R:R:Y96	3.52	3	Yes	No	3	6	1	2
R:R:F101	R:R:V97	7.87	0	No	No	4	5	1	2
R:R:P287	R:R:V97	1.77	0	Yes	No	4	5	2	2
R:R:L173	R:R:S114	4.5	0	Yes	No	4	5	2	1
R:R:R176	R:R:S114	11.86	3	Yes	No	4	5	2	1
R:R:F122	R:R:Q118	10.54	0	Yes	No	6	5	2	1
R:R:G169	R:R:Q118	4.93	0	No	No	7	5	2	1
R:R:F122	R:R:M121	4.98	0	Yes	Yes	6	7	2	1
R:R:M121	R:R:W259	8.14	0	Yes	Yes	7	8	1	2
R:R:F122	R:R:K210	6.2	0	Yes	No	6	6	2	1
R:R:N189	R:R:R176	2.41	3	No	Yes	4	4	1	2
R:R:V179	R:R:Y188	6.31	0	No	Yes	1	3	2	1
R:R:F191	R:R:Y188	4.13	3	Yes	Yes	5	3	1	1
R:R:Q192	R:R:Y188	7.89	0	No	Yes	4	3	1	1
R:R:F191	R:R:N189	2.42	3	Yes	No	5	4	1	1
R:R:E269	R:R:F191	7	0	No	Yes	4	5	1	1
R:R:K193	R:R:Q192	5.42	0	No	No	2	4	2	1
R:R:K210	R:R:Y262	3.58	0	No	Yes	6	6	1	1
R:R:H263	R:R:Y262	5.44	0	No	Yes	8	6	2	1
R:R:T290	R:R:Y262	2.5	2	Yes	Yes	6	6	1	1
R:R:F265	R:R:I286	6.28	2	No	Yes	4	4	2	1
R:R:F265	R:R:S289	5.28	2	No	No	4	7	2	2
R:R:H279	R:R:H280	2.39	0	No	No	1	3	2	1
R:R:I286	R:R:P287	3.39	2	Yes	Yes	4	4	1	2
R:R:I286	R:R:S289	3.1	2	Yes	No	4	7	1	2
R:R:G291	R:R:T290	1.82	0	No	Yes	4	6	2	1
R:R:F294	R:R:G291	6.02	2	Yes	No	7	4	2	2
R:R:I272	R:R:Y277	1.21	0	No	Yes	2	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9UYJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.62
Number of Linked Nodes	599
Number of Links	785
Number of Hubs	146
Number of Links mediated by Hubs	497
Number of Communities	15
Number of Nodes involved in Communities	204
Number of Links involved in Communities	308

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	821226
Length Of Smallest Path	3
Average Path Length	25.752
Length of Longest Path	49
Minimum Path Strength	1.29
Average Path Strength	5.58217
Maximum Path Strength	20.515
Minimum Path Correlation	0.7
Average Path Correlation	0.97259
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	46.2206
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.8875
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • arrestin family protein binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • angiotensin receptor binding • signaling receptor binding • G protein-coupled receptor binding • molecular adaptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • insulin-like growth factor receptor binding • molecular function inhibitor activity • enzyme inhibitor activity • transcription coactivator activity • transcription regulator activity • transcription coregulator activity • protein-macromolecule adaptor activity • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • interleukin-6 production • multicellular organismal process • regulation of cellular process • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production
Gene Ontology	Biological Process	• cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • interleukin-6 production • multicellular organismal process • regulation of cellular process • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of biological process • negative regulation of metabolic process • biological regulation • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of interleukin-6 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • negative regulation of post-translational protein modification • regulation of protein modification process • regulation of protein ubiquitination • regulation of primary metabolic process • protein ubiquitination • negative regulation of protein modification process • protein metabolic process • negative regulation of protein ubiquitination • regulation of protein modification by small protein conjugation or removal • protein modification process • negative regulation of protein metabolic process • negative regulation of protein modification by small protein conjugation or removal • regulation of post-translational protein modification • regulation of protein metabolic process • primary metabolic process • macromolecule modification • post-translational protein modification • protein modification by small protein conjugation • protein modification by small protein conjugation or removal • actomyosin structure organization • actin cytoskeleton organization • actin filament organization • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • actin filament bundle organization • contractile actin filament bundle assembly • actin filament-based process • actin filament bundle assembly • stress fiber assembly • cellular component organization or biogenesis • supramolecular fiber organization • cytoskeleton organization • cellular response to stimulus • negative adaptation of signaling pathway • response to stimulus • negative regulation of signaling • signaling • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • cell communication • signal transduction • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of response to stimulus • adaptation of signaling pathway • regulation of cell communication • G protein-coupled receptor signaling pathway • system process • sensory perception • nervous system process • catabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • regulation of system process • positive regulation of biological process • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • positive regulation of multicellular organismal process • negative regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • import into cell • receptor internalization • transport • vesicle-mediated transport • localization • G protein-coupled receptor internalization • establishment of localization • receptor-mediated endocytosis • endocytosis • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • establishment of protein localization • protein transport • macromolecule localization • intracellular protein localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • proteasomal protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • cell surface receptor signaling pathway • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of phosphorus metabolic process • regulation of phosphorylation • cell projection • cellular anatomical structure • pseudopodium • plasma membrane bounded cell projection • clathrin-coated pit • membrane • endomembrane system • intracellular anatomical structure • cytoplasm • cytosol • intracellular organelle • organelle • membraneless organelle • intracellular membraneless organelle
Gene Ontology	Cellular Component	• cell projection • cellular anatomical structure • pseudopodium • plasma membrane bounded cell projection • clathrin-coated pit • membrane • endomembrane system • intracellular anatomical structure • cytoplasm • cytosol • intracellular organelle • organelle • membraneless organelle • intracellular membraneless organelle • chromatin • chromosome • membrane-bounded organelle • intracellular vesicle • intracellular membrane-bounded organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • vesicle • organelle membrane • endocytic vesicle • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi membrane • Golgi apparatus • cell periphery • plasma membrane • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • nuclear body • vasopressin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • binding • adipokinetic hormone binding • peptide hormone binding • hormone binding • protein-hormone receptor activity • adipokinetic hormone receptor activity • neuropeptide binding • peptide binding • regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • renal system process • transport • homeostatic process • fluid transport • establishment of localization • water transport • renal water transport • localization • multicellular organismal-level homeostasis • chemical homeostasis • renal absorption • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water absorption • renal water homeostasis • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • neuropeptide signaling pathway • glucose homeostasis • carbohydrate homeostasis • clathrin-coated vesicle • coated vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • coated vesicle membrane • endosome • perinuclear region of cytoplasm • endoplasmic reticulum • neuron projection • protein binding • signaling receptor binding • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response • immune response • defense response to symbiont • response to external stimulus • antimicrobial humoral response • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • immune system process • antifungal humoral response • response to external biotic stimulus • response to fungus • cellular developmental process • cell differentiation • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to external stimulus • taxis • regulation of locomotion • locomotion • response to activity • digestive system development • tube development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • innate immune response • lipid catabolic process • catabolic process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • lipid metabolic process • response to nutrient levels • response to caloric restriction • regulation of cell motility • macrophage migration • positive regulation of cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • antifungal innate immune response • cellular response to nitrogen compound • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • inflammatory response • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • vesicle lumen • cytoplasmic vesicle lumen • secretory granule lumen • platelet dense granule lumen • platelet dense granule • secretory granule • secretory vesicle • extracellular matrix • external encapsulating structure • extracellular region • extracellular space
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TPO
PDB Residues	R:R:?1359 R:R:?1360
Environment Details	Open EMBL-EBI Page
Code	TPO
Name	PHOSPHOTHREONINE
Synonyms	PHOSPHONOTHREONINE
Identifier
Formula	C4 H10 N O6 P
Molecular Weight	199.099
SMILES
PubChem	139055008
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	2
Total Bonds	21
Total Aromatic Bonds	0


Code	SEP
PDB Residues	R:R:?1362 R:R:?1363 R:R:?1364
Environment Details	Open EMBL-EBI Page
Code	SEP
Name	Dexfosfoserine
Synonyms	PHOSPHONOSERINE
Identifier
Formula	C3 H8 N O6 P
Molecular Weight	185.072
SMILES
PubChem	57689797
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Chemerin-9
UniProt	Q99969
Sequence	>9UYJ_nogp_Chain_L S F Y F P G Q F A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46091
Sequence	>9UYJ_nogp_Chain_R V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W K K T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N F H W P F G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H P V L S H R H R T L K N S L I V I I F I W L L A S L I G G P A L Y F R D T V E F N N H T L C Y N N F Q K H D P D L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S I L I S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H N S Y S H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F Q A S C ??A ???L A K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P49407
Sequence	>9UYJ_nogp_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V D P V D G V V L V D P E Y L K E R R V Y V T L T A F R Y G F R K D L F V A N V Q S F P P K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P S V T L Q P A G V D Y E V K A F A E N L E E K I H K R N S V R L V I K V Q Y A P E R P G P Q P T A E T T R Q D K P L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I L F N T A Q Y K P V A M E E A D D T V A P S S T F K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V V D V A V E L P F T L M H P K P K E E P P H R E V P E N A S I V E V V S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JJP	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8JJP (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	9L3Y	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Y (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9UYH	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYH (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYI	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.2	2025-11-19	10.1126/science.adt8794
	9UYI (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.2	2025-11-19	10.1126/science.adt8794
	9UYJ	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYJ (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYL	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYL (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	chim(Arrestin3-CtArrestin2)	3.5	2025-11-19	10.1126/science.adt8794
	9UYM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.5	2025-11-19	10.1126/science.adt8794
	9UYN	A	Protein	Chemerin	CML2	Homo sapiens	-	-	Arrestin2	2.9	2025-11-19	10.1126/science.adt8794
	9UYN (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	-	-		2.9	2025-11-19	10.1126/science.adt8794

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