psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F148	R:R:H280	5.66	No	No	0	1	3
2	L:L:Y149	R:R:H280	2.18	No	No	0	5	3
3	L:L:Y149	R:R:M282	14.37	No	No	0	5	4
4	L:L:F150	L:L:P151	7.22	No	No	0	4	9
5	L:L:P151	R:R:Y277	5.56	No	No	0	9	1
6	L:L:G152	R:R:Y188	2.9	No	Yes	0	9	3
7	L:L:Q153	R:R:F175	2.34	No	No	8	6	4
8	L:L:Q153	R:R:N190	7.92	No	No	0	6	3
9	L:L:Q153	R:R:L206	2.66	No	Yes	8	6	5
10	L:L:F154	R:R:C110	2.79	Yes	Yes	2	6	9
11	L:L:F154	R:R:K111	2.48	Yes	No	2	6	7
12	L:L:F154	R:R:S114	7.93	Yes	No	0	6	5
13	L:L:F154	R:R:R176	2.14	Yes	Yes	2	6	4
14	L:L:F154	R:R:D177	15.52	Yes	No	0	6	5
15	L:L:F156	R:R:Y93	16.5	Yes	Yes	2	9	6
16	L:L:F156	R:R:M121	7.46	Yes	Yes	2	9	7
17	L:L:F156	R:R:Y262	5.16	Yes	Yes	2	9	6
18	L:L:F156	R:R:S289	3.96	Yes	No	2	9	7
19	R:R:L42	R:R:V43	4.47	No	No	0	5	5
20	R:R:A98	R:R:L42	3.15	No	No	0	4	5
21	R:R:L44	R:R:T290	5.9	No	No	2	5	6
22	R:R:G291	R:R:L44	5.13	No	No	2	4	5
23	R:R:F294	R:R:L44	3.65	Yes	No	2	7	5
24	R:R:C46	R:R:Y45	6.72	No	No	0	5	8
25	R:R:L90	R:R:Y45	10.55	Yes	No	0	7	8
26	R:R:I94	R:R:Y45	22.97	No	No	0	6	8
27	R:R:F294	R:R:L47	8.53	Yes	No	0	7	4
28	R:R:A48	R:R:F294	5.55	No	Yes	0	6	7
29	R:R:F49	R:R:I53	10.05	No	No	9	7	6
30	R:R:F49	R:R:L87	8.53	No	Yes	9	7	6
31	R:R:F49	R:R:L90	6.09	No	Yes	9	7	7
32	R:R:C298	R:R:L51	4.76	No	No	0	7	5
33	R:R:G52	R:R:P54	2.03	No	No	0	8	4
34	R:R:I53	R:R:P54	5.08	No	No	0	6	4
35	R:R:I53	R:R:L87	2.85	No	Yes	9	6	6
36	R:R:G55	R:R:P54	2.03	No	No	0	7	4
37	R:R:G55	R:R:I58	3.53	No	No	0	7	6
38	R:R:G55	R:R:P301	2.03	No	No	0	7	9
39	R:R:F84	R:R:N56	20.54	No	No	9	7	9
40	R:R:L87	R:R:N56	12.36	Yes	No	9	6	9
41	R:R:A80	R:R:V59	5.09	No	No	0	8	8
42	R:R:G64	R:R:I60	7.05	No	No	0	3	7
43	R:R:F65	R:R:W61	9.02	No	No	0	4	4
44	R:R:F62	R:R:F65	8.57	No	No	0	7	4
45	R:R:F62	R:R:K69	2.48	No	No	0	7	7
46	R:R:T63	R:R:W67	7.28	No	No	0	7	6
47	R:R:F76	R:R:T63	3.89	No	No	0	8	7
48	R:R:K68	R:R:T70	10.51	No	No	0	7	7
49	R:R:K69	R:R:L151	2.82	No	No	0	7	3
50	R:R:T70	R:R:T72	6.28	No	No	4	7	7
51	R:R:T70	R:R:T73	6.28	No	No	4	7	8
52	R:R:V71	R:R:W75	12.26	No	Yes	4	6	7
53	R:R:H148	R:R:V71	2.77	Yes	No	4	3	6
54	R:R:S154	R:R:V71	6.46	Yes	No	4	7	6
55	R:R:T72	R:R:T73	3.14	No	No	4	7	8
56	R:R:T72	R:R:W75	2.43	No	Yes	4	7	7
57	R:R:L74	R:R:S154	6.01	No	Yes	0	6	7
58	R:R:F127	R:R:W75	4.01	Yes	Yes	4	7	7
59	R:R:D134	R:R:W75	12.28	No	Yes	0	8	7
60	R:R:H148	R:R:W75	10.58	Yes	Yes	4	3	7
61	R:R:S154	R:R:W75	3.71	Yes	Yes	4	7	7
62	R:R:F76	R:R:L79	6.09	No	Yes	4	8	9
63	R:R:F76	R:R:Y304	10.32	No	Yes	4	8	9
64	R:R:I81	R:R:L77	4.28	No	No	0	5	6
65	R:R:F127	R:R:N78	20.54	Yes	No	4	7	9
66	R:R:I158	R:R:N78	18.41	No	No	4	7	9
67	R:R:N78	R:R:W162	3.39	No	No	4	9	9
68	R:R:F127	R:R:L79	9.74	Yes	Yes	4	7	9
69	R:R:I131	R:R:L79	2.85	Yes	Yes	4	8	9
70	R:R:L79	R:R:N300	6.87	Yes	Yes	4	9	9
71	R:R:L79	R:R:Y304	17.58	Yes	Yes	4	9	9
72	R:R:D83	R:R:N300	5.39	No	Yes	4	9	9
73	R:R:D83	R:R:P301	3.22	No	No	4	9	9
74	R:R:F84	R:R:L87	3.65	No	Yes	9	7	6
75	R:R:F84	R:R:L88	2.44	No	No	0	7	5
76	R:R:I85	R:R:L88	2.85	No	No	0	6	5
77	R:R:I85	R:R:N120	12.74	No	Yes	0	6	8
78	R:R:F86	R:R:F89	10.72	No	Yes	11	7	6
79	R:R:F86	R:R:N120	3.62	No	Yes	11	7	8
80	R:R:A293	R:R:F86	2.77	No	No	0	8	7
81	R:R:L87	R:R:L90	4.15	Yes	Yes	9	6	7
82	R:R:F89	R:R:T116	5.19	Yes	No	0	6	5
83	R:R:A117	R:R:F89	4.16	No	Yes	0	6	6
84	R:R:F89	R:R:N120	7.25	Yes	Yes	11	6	8
85	R:R:L92	R:R:Y93	2.34	Yes	Yes	2	6	6
86	R:R:L92	R:R:W103	10.25	Yes	Yes	2	6	9
87	R:R:L109	R:R:L92	4.15	Yes	Yes	2	5	6
88	R:R:L92	R:R:N113	20.6	Yes	No	2	6	5
89	R:R:Y93	R:R:Y96	2.98	Yes	Yes	2	6	6
90	R:R:I286	R:R:Y93	7.25	Yes	Yes	2	4	6
91	R:R:T290	R:R:Y93	7.49	No	Yes	2	6	6
92	R:R:A98	R:R:I94	3.25	No	No	0	4	6
93	R:R:S95	R:R:W103	8.65	No	Yes	0	4	9
94	R:R:V97	R:R:Y96	3.79	No	Yes	2	5	6
95	R:R:Y188	R:R:Y96	2.98	Yes	Yes	0	3	6
96	R:R:I286	R:R:Y96	2.42	Yes	Yes	2	4	6
97	R:R:I286	R:R:V97	9.22	Yes	No	2	4	5
98	R:R:M99	R:R:N100	4.21	No	No	0	4	3
99	R:R:H102	R:R:N100	3.83	No	No	0	5	3
100	R:R:H102	R:R:H184	2.39	No	No	0	5	3
101	R:R:H102	R:R:T185	5.48	No	No	0	5	4
102	R:R:P104	R:R:W103	20.27	No	Yes	0	3	9
103	R:R:F105	R:R:W103	8.02	No	Yes	2	7	9
104	R:R:L109	R:R:W103	35.31	Yes	Yes	2	5	9
105	R:R:N113	R:R:W103	2.26	No	Yes	2	5	9
106	R:R:F105	R:R:L109	6.09	No	Yes	2	7	5
107	R:R:C110	R:R:G106	1.96	Yes	No	2	9	7
108	R:R:G106	R:R:T185	1.82	No	No	0	7	4
109	R:R:C187	R:R:G106	1.96	No	No	2	9	7
110	R:R:I107	R:R:W108	15.27	No	No	0	4	1
111	R:R:I107	R:R:T178	3.04	No	Yes	0	4	5
112	R:R:C110	R:R:L109	3.17	Yes	Yes	2	9	5
113	R:R:L109	R:R:N113	10.98	Yes	No	2	5	5
114	R:R:C110	R:R:C187	7.28	Yes	No	2	9	9
115	R:R:K111	R:R:R176	13.61	No	Yes	2	7	4
116	R:R:F115	R:R:L119	7.31	No	No	0	6	5
117	R:R:F115	R:R:L173	12.18	No	No	0	6	4
118	R:R:M121	R:R:Q118	8.16	Yes	No	2	7	5
119	R:R:F122	R:R:Q118	10.54	Yes	No	2	6	5
120	R:R:F122	R:R:M121	2.49	Yes	Yes	2	6	7
121	R:R:M121	R:R:S124	3.07	Yes	No	0	7	9
122	R:R:M121	R:R:W259	4.65	Yes	Yes	2	7	8
123	R:R:F122	R:R:I168	7.54	Yes	No	0	6	5
124	R:R:F122	R:R:K210	7.44	Yes	No	0	6	6
125	R:R:A123	R:R:A165	1.79	No	No	0	6	8
126	R:R:P218	R:R:V125	3.53	No	No	0	9	7
127	R:R:F255	R:R:V125	5.24	Yes	No	2	9	7
128	R:R:V125	R:R:W259	9.81	No	Yes	2	7	8
129	R:R:F126	R:R:T129	5.19	Yes	Yes	0	5	7
130	R:R:F126	R:R:I161	5.02	Yes	No	0	5	7
131	R:R:F126	R:R:L164	9.74	Yes	No	0	5	4
132	R:R:F126	R:R:I213	2.51	Yes	No	0	5	4
133	R:R:F127	R:R:V130	3.93	Yes	No	0	7	6
134	R:R:F127	R:R:I131	7.54	Yes	Yes	4	7	8
135	R:R:F127	R:R:I158	2.51	Yes	No	4	7	7
136	R:R:I131	R:R:L128	2.85	Yes	No	0	8	9
137	R:R:F255	R:R:L128	7.31	Yes	No	0	9	9
138	R:R:T129	R:R:V130	3.17	Yes	No	0	7	6
139	R:R:P218	R:R:T129	3.5	No	Yes	0	9	7
140	R:R:T129	R:R:T221	3.14	Yes	No	0	7	6
141	R:R:I161	R:R:V130	3.07	No	No	0	7	6
142	R:R:H135	R:R:I131	2.65	No	Yes	4	9	8
143	R:R:I131	R:R:Y304	14.51	Yes	Yes	4	8	9
144	R:R:C225	R:R:S132	5.16	No	No	0	6	9
145	R:R:I137	R:R:L133	2.85	No	No	0	5	6
146	R:R:D134	R:R:H135	11.35	No	No	0	8	9
147	R:R:H135	R:R:Y304	5.44	No	Yes	4	9	9
148	R:R:I140	R:R:Y136	29.01	No	No	0	7	7
149	R:R:C225	R:R:Y136	8.06	No	No	0	6	7
150	R:R:I137	R:R:R147	7.52	No	No	0	5	5
151	R:R:I140	R:R:I230	2.94	No	No	0	7	4
152	R:R:H141	R:R:P142	6.1	Yes	Yes	3	6	8
153	R:R:H141	R:R:V143	9.69	Yes	No	0	6	5
154	R:R:H141	V:V:L243	12.86	Yes	Yes	3	6	7
155	R:R:H141	V:V:F244	19.23	Yes	Yes	3	6	8
156	R:R:H141	V:V:N245	17.86	Yes	No	0	6	8
157	R:R:P142	V:V:Y63	11.13	Yes	No	3	8	9
158	R:R:P142	V:V:L243	4.93	Yes	Yes	3	8	7
159	R:R:P142	V:V:F244	2.89	Yes	Yes	3	8	8
160	R:R:V143	V:V:I241	3.07	No	No	0	5	8
161	R:R:V143	V:V:Y249	7.57	No	No	0	5	7
162	R:R:L144	R:R:R149	2.43	No	No	0	5	7
163	R:R:S145	V:V:L129	3	No	No	0	6	8
164	R:R:H146	V:V:V251	6.92	No	Yes	0	5	6
165	R:R:H146	V:V:G286	4.77	No	No	0	5	9
166	R:R:R147	V:V:Y249	3.09	No	No	0	5	7
167	R:R:H148	R:R:N153	12.75	Yes	No	0	3	4
168	R:R:H148	R:R:S154	6.97	Yes	Yes	4	3	7
169	R:R:H148	R:R:V157	5.54	Yes	No	0	3	6
170	R:R:R149	V:V:I140	3.76	No	No	0	7	9
171	R:R:R149	V:V:R285	10.66	No	Yes	0	7	7
172	R:R:N153	R:R:T150	2.92	No	No	0	4	6
173	R:R:T150	V:V:R285	5.17	No	Yes	0	6	7
174	R:R:F160	R:R:I156	7.54	No	No	0	3	3
175	R:R:I161	R:R:V157	3.07	No	No	0	7	6
176	R:R:I158	R:R:W162	2.35	No	No	4	7	9
177	R:R:G169	R:R:I168	1.76	No	No	0	7	5
178	R:R:I168	R:R:I213	4.42	No	No	0	5	4
179	R:R:G169	R:R:G170	2.11	No	No	0	7	4
180	R:R:A172	R:R:G169	1.95	No	No	0	4	7
181	R:R:G170	R:R:P171	4.06	No	No	0	4	8
182	R:R:G170	R:R:L173	5.13	No	No	0	4	4
183	R:R:F175	R:R:L206	2.44	No	Yes	8	4	5
184	R:R:R176	R:R:T178	5.17	Yes	Yes	2	4	5
185	R:R:F191	R:R:R176	8.55	Yes	Yes	2	5	4
186	R:R:K193	R:R:R176	3.71	No	Yes	2	2	4
187	R:R:D177	R:R:Y188	3.45	No	Yes	0	5	3
188	R:R:D177	R:R:N190	13.46	No	No	0	5	3
189	R:R:T178	R:R:V179	3.17	Yes	No	0	5	1
190	R:R:F191	R:R:T178	3.89	Yes	Yes	2	5	5
191	R:R:F181	R:R:V179	5.24	No	No	0	4	1
192	R:R:E180	R:R:N182	6.57	No	No	0	1	3
193	R:R:E180	R:R:H184	3.69	No	No	0	1	3
194	R:R:E180	R:R:L186	7.95	No	No	0	1	3
195	R:R:L186	R:R:Y188	16.41	No	Yes	0	3	3
196	R:R:K193	R:R:N190	15.39	No	No	0	2	3
197	R:R:F191	R:R:K193	2.48	Yes	No	2	5	2
198	R:R:H194	R:R:R202	3.39	No	No	0	3	1
199	R:R:H203	R:R:H204	19.11	No	No	8	4	4
200	R:R:H203	R:R:H273	7.17	No	Yes	8	4	3
201	R:R:H204	R:R:L270	7.71	No	No	8	4	5
202	R:R:H204	R:R:H273	2.39	No	Yes	8	4	3
203	R:R:L206	R:R:T207	4.42	Yes	No	0	5	5
204	R:R:S266	R:R:T207	3.2	No	No	0	5	5
205	R:R:F211	R:R:W208	7.02	No	No	0	6	4
206	R:R:I212	R:R:W208	7.05	No	No	0	5	4
207	R:R:I267	R:R:W208	2.35	No	No	0	5	4
208	R:R:K210	R:R:Y262	9.55	No	Yes	0	6	6
209	R:R:F211	R:R:Y215	6.19	No	Yes	2	6	8
210	R:R:F211	R:R:H263	6.79	No	Yes	2	6	8
211	R:R:I212	R:R:L216	11.42	No	No	13	5	4
212	R:R:F217	R:R:I212	3.77	No	No	13	6	5
213	R:R:G214	R:R:P218	4.06	No	No	0	5	9
214	R:R:G214	R:R:W259	2.81	No	Yes	2	5	8
215	R:R:G214	R:R:H263	3.18	No	Yes	2	5	8
216	R:R:L219	R:R:Y215	17.58	No	Yes	0	6	8
217	R:R:W259	R:R:Y215	1.93	Yes	Yes	2	8	8
218	R:R:T260	R:R:Y215	7.49	No	Yes	0	5	8
219	R:R:H263	R:R:Y215	9.8	Yes	Yes	2	8	8
220	R:R:F217	R:R:L216	6.09	No	No	13	6	4
221	R:R:M222	R:R:V252	6.09	No	No	0	8	7
222	R:R:F255	R:R:M222	6.22	Yes	No	0	9	8
223	R:R:C225	R:R:I224	3.27	No	No	0	6	4
224	R:R:V252	R:R:Y226	5.05	No	No	0	7	9
225	R:R:I230	R:R:L227	4.28	No	No	0	4	3
226	R:R:A254	R:R:L299	6.3	No	No	0	7	7
227	R:R:C258	R:R:F255	4.19	Yes	Yes	2	7	9
228	R:R:F255	R:R:W259	16.04	Yes	Yes	2	9	8
229	R:R:C258	R:R:W259	3.92	Yes	Yes	2	7	8
230	R:R:C258	R:R:L292	3.17	Yes	No	0	7	7
231	R:R:W259	R:R:Y262	2.89	Yes	Yes	2	8	6
232	R:R:H263	R:R:W259	12.7	Yes	Yes	2	8	8
233	R:R:P261	R:R:T260	5.25	No	No	0	9	5
234	R:R:L292	R:R:P261	13.14	No	No	0	7	9
235	R:R:S289	R:R:Y262	15.26	No	Yes	2	7	6
236	R:R:L264	R:R:W268	15.94	No	No	0	5	4
237	R:R:F265	R:R:W268	2	No	No	0	4	4
238	R:R:F265	R:R:G285	3.01	No	No	0	4	6
239	R:R:F265	R:R:L288	10.96	No	No	0	4	5
240	R:R:E269	R:R:S266	4.31	No	No	0	4	5
241	R:R:I267	R:R:W268	2.35	No	No	0	5	4
242	R:R:H273	R:R:L270	3.86	Yes	No	8	3	5
243	R:R:H273	R:R:Y277	9.8	Yes	No	0	3	1
244	R:R:N275	R:R:S276	7.45	No	No	0	3	3
245	R:R:Q283	R:R:S278	7.22	No	No	0	3	2
246	R:R:A284	R:R:M282	4.83	No	No	0	2	4
247	R:R:G285	R:R:P287	2.03	No	No	0	6	4
248	R:R:I286	R:R:P287	6.77	Yes	No	0	4	4
249	R:R:L288	R:R:L292	2.77	No	No	0	5	7
250	R:R:G291	R:R:T290	3.64	No	No	2	4	6
251	R:R:F294	R:R:G291	3.01	Yes	No	2	7	4
252	R:R:C298	R:R:F294	6.98	No	Yes	0	7	7
253	R:R:L295	R:R:L299	4.15	No	No	0	5	7
254	R:R:N300	R:R:P301	9.77	Yes	No	4	9	9
255	R:R:N300	R:R:Y304	4.65	Yes	Yes	4	9	9
256	R:R:L303	R:R:Y304	4.69	No	Yes	0	8	9
257	R:R:?1357	R:R:C1358	4.05	No	No	0	6	5
258	R:R:?1357	V:V:K11	2.4	No	Yes	0	6	9
259	R:R:?1357	V:V:R165	8.26	No	Yes	0	6	5
260	R:R:?1359	R:R:C1358	5.21	No	No	0	4	5
261	R:R:C1358	V:V:P14	3.77	No	No	0	5	6
262	R:R:?1359	R:R:?1360	23.33	No	Yes	1	4	6
263	R:R:?1359	V:V:K11	3.47	No	Yes	1	4	9
264	R:R:?1360	R:R:A1361	2.59	Yes	No	0	6	7
265	R:R:?1360	V:V:F9	2	Yes	No	1	6	6
266	R:R:?1360	V:V:K11	17.37	Yes	Yes	1	6	9
267	R:R:?1360	V:V:R25	12.97	Yes	Yes	1	6	9
268	R:R:?1360	V:V:K294	2.32	Yes	No	0	6	9
269	R:R:?1362	R:R:A1361	4.02	Yes	No	0	4	7
270	R:R:?1362	R:R:?1363	18.02	Yes	Yes	6	4	7
271	R:R:?1362	V:V:R7	20.66	Yes	No	6	4	4
272	R:R:?1362	V:V:K10	2.4	Yes	No	6	4	9
273	R:R:?1363	R:R:?1364	23.02	Yes	No	6	7	5
274	R:R:?1363	V:V:R7	13.43	Yes	No	6	7	4
275	R:R:?1363	V:V:K10	6	Yes	No	6	7	9
276	R:R:?1363	V:V:Y21	5.98	Yes	Yes	6	7	8
277	R:R:?1363	V:V:K107	10.79	Yes	No	6	7	9
278	R:R:?1364	R:R:L1365	8.24	No	Yes	6	5	5
279	R:R:?1364	V:V:K107	9.59	No	No	6	5	9
280	R:R:L1365	V:V:T6	7.37	Yes	No	6	5	4
281	R:R:L1365	V:V:V8	7.45	Yes	No	0	5	7
282	R:R:L1365	V:V:R103	4.86	Yes	No	6	5	6
283	R:R:L1365	V:V:L104	4.15	Yes	Yes	6	5	9
284	V:V:R103	V:V:T6	3.88	No	No	6	6	4
285	V:V:V8	V:V:Y21	2.52	No	Yes	0	7	8
286	V:V:G23	V:V:V8	3.68	No	No	0	8	7
287	V:V:F9	V:V:R25	4.28	No	Yes	1	6	9
288	V:V:K10	V:V:Y21	8.36	No	Yes	6	9	8
289	V:V:K11	V:V:L166	7.05	Yes	No	0	9	8
290	V:V:P14	V:V:S13	3.56	No	No	0	6	8
291	V:V:N15	V:V:S13	8.94	No	No	0	8	8
292	V:V:N15	V:V:N162	5.45	No	No	0	8	8
293	V:V:K17	V:V:L18	11.28	Yes	No	0	5	6
294	V:V:K17	V:V:V43	9.11	Yes	Yes	7	5	6
295	V:V:D44	V:V:K17	13.83	Yes	Yes	7	8	5
296	V:V:K17	V:V:Y47	14.33	Yes	Yes	7	5	5
297	V:V:L18	V:V:V150	2.98	No	Yes	0	6	5
298	V:V:T19	V:V:Y21	3.75	No	Yes	0	7	8
299	V:V:L42	V:V:T19	2.95	No	No	0	5	7
300	V:V:F115	V:V:V20	2.62	Yes	No	0	9	6
301	V:V:V164	V:V:V20	4.81	No	No	0	8	6
302	V:V:L104	V:V:Y21	2.34	Yes	Yes	6	9	8
303	V:V:L108	V:V:Y21	4.69	Yes	Yes	6	8	8
304	V:V:F115	V:V:L22	2.44	Yes	No	0	9	8
305	V:V:L166	V:V:L22	5.54	No	No	0	8	8
306	V:V:G23	V:V:L100	3.42	No	No	0	8	5
307	V:V:F27	V:V:K24	7.44	No	No	0	8	7
308	V:V:L166	V:V:R25	9.72	No	Yes	0	8	9
309	V:V:L293	V:V:R25	6.07	No	Yes	1	8	9
310	V:V:D26	V:V:E169	2.6	Yes	Yes	1	9	9
311	V:V:D26	V:V:V171	4.38	Yes	Yes	1	9	6
312	V:V:D26	V:V:Y173	8.05	Yes	Yes	1	9	4
313	V:V:D26	V:V:P360	11.27	Yes	Yes	1	9	1
314	V:V:D26	V:V:H362	13.87	Yes	Yes	1	9	1
315	V:V:F27	V:V:V37	13.11	No	No	0	8	8
316	V:V:F27	V:V:I168	7.54	No	No	0	8	8
317	V:V:H30	V:V:V28	4.15	No	No	1	6	8
318	V:V:D35	V:V:V28	2.92	No	No	1	6	8
319	V:V:V28	V:V:Y173	3.79	No	Yes	1	8	4
320	V:V:D29	V:V:V34	2.92	No	No	3	9	7
321	V:V:D29	V:V:K170	13.83	No	No	3	9	9
322	V:V:D29	V:V:Q172	5.22	No	No	3	9	9
323	V:V:D32	V:V:H30	2.52	No	No	0	4	6
324	V:V:D35	V:V:H30	2.52	No	No	1	6	6
325	V:V:D32	V:V:I31	5.6	No	No	0	4	5
326	V:V:D32	V:V:L33	6.79	No	No	0	4	3
327	V:V:I119	V:V:V34	10.75	No	No	3	5	7
328	V:V:K170	V:V:V34	6.07	No	No	3	9	7
329	V:V:D35	V:V:P36	3.22	No	No	0	6	5
330	V:V:F117	V:V:V37	5.24	Yes	No	0	8	8
331	V:V:D38	V:V:G39	3.35	No	No	0	7	8
332	V:V:D38	V:V:T98	7.23	No	No	0	7	8
333	V:V:F115	V:V:G39	4.52	Yes	No	0	9	8
334	V:V:Q101	V:V:V40	4.3	Yes	No	0	9	8
335	V:V:L104	V:V:V40	7.45	Yes	No	0	9	8
336	V:V:V41	V:V:V53	3.21	No	Yes	0	5	7
337	V:V:L108	V:V:L42	4.15	Yes	No	0	8	5
338	V:V:L48	V:V:V43	2.98	Yes	Yes	7	4	6
339	V:V:V43	V:V:V53	6.41	Yes	Yes	7	6	7
340	V:V:V43	V:V:Y113	2.52	Yes	Yes	7	6	3
341	V:V:D44	V:V:Y47	4.6	Yes	Yes	7	8	5
342	V:V:H111	V:V:P45	4.58	No	No	0	6	4
343	V:V:R51	V:V:Y47	8.23	Yes	Yes	7	6	5
344	V:V:V150	V:V:Y47	10.09	Yes	Yes	7	5	5
345	V:V:N162	V:V:Y47	10.47	No	Yes	0	8	5
346	V:V:L48	V:V:V53	2.98	Yes	Yes	7	4	7
347	V:V:F87	V:V:L48	7.31	Yes	Yes	7	4	4
348	V:V:L48	V:V:Y113	3.52	Yes	Yes	7	4	3
349	V:V:R51	V:V:V150	2.62	Yes	Yes	7	6	5
350	V:V:E152	V:V:R51	6.98	No	Yes	0	4	6
351	V:V:Q85	V:V:R52	7.01	No	No	0	9	6
352	V:V:S86	V:V:V53	4.85	No	Yes	0	6	7
353	V:V:F87	V:V:V53	3.93	Yes	Yes	7	4	7
354	V:V:V150	V:V:V53	3.21	Yes	Yes	7	5	7
355	V:V:T56	V:V:Y54	2.5	No	No	10	7	4
356	V:V:F149	V:V:Y54	9.28	Yes	No	10	5	4
357	V:V:L154	V:V:Y54	2.34	No	No	0	3	4
358	V:V:F115	V:V:V55	13.11	Yes	No	14	9	8
359	V:V:F117	V:V:V55	5.24	Yes	No	14	8	8
360	V:V:N83	V:V:T56	8.77	No	No	0	5	7
361	V:V:F149	V:V:T56	3.89	Yes	No	10	5	7
362	V:V:F117	V:V:L57	19.49	Yes	No	0	8	7
363	V:V:D78	V:V:T58	7.23	No	No	0	8	7
364	V:V:E145	V:V:T58	2.82	Yes	No	0	7	7
365	V:V:A59	V:V:Y144	4	No	Yes	0	8	7
366	V:V:A60	V:V:D143	3.09	No	No	0	8	7
367	V:V:F61	V:V:V142	3.93	Yes	Yes	3	9	9
368	V:V:F61	V:V:L243	4.87	Yes	Yes	3	9	7
369	V:V:F61	V:V:G316	4.52	Yes	Yes	3	9	8
370	V:V:F61	V:V:I317	3.77	Yes	Yes	3	9	8
371	V:V:F75	V:V:Y63	17.54	No	No	0	9	9
372	V:V:L243	V:V:Y63	2.34	Yes	No	3	7	9
373	V:V:F244	V:V:K77	7.44	Yes	No	0	8	9
374	V:V:D78	V:V:V81	4.38	No	No	0	8	4
375	V:V:L79	V:V:P124	3.28	No	Yes	0	8	9
376	V:V:L315	V:V:L79	2.77	No	No	0	5	8
377	V:V:A82	V:V:F80	2.77	No	Yes	0	4	4
378	V:V:F80	V:V:I119	3.77	Yes	No	3	4	5
379	V:V:F80	V:V:P120	7.22	Yes	Yes	3	4	7
380	V:V:F80	V:V:L123	2.44	Yes	No	3	4	6
381	V:V:F117	V:V:V84	2.62	Yes	No	0	8	3
382	V:V:S86	V:V:Y113	2.54	No	Yes	0	6	3
383	V:V:F87	V:V:P88	2.89	Yes	No	0	4	9
384	V:V:F87	V:V:Y113	11.35	Yes	Yes	7	4	3
385	V:V:K95	V:V:T116	6.01	No	No	0	3	4
386	V:V:L97	V:V:Q101	7.99	Yes	Yes	15	4	9
387	V:V:E102	V:V:L97	5.3	No	Yes	0	6	4
388	V:V:L97	V:V:P114	3.28	Yes	No	15	4	8
389	V:V:Q101	V:V:T98	2.83	Yes	No	0	9	8
390	V:V:L100	V:V:L104	2.77	No	Yes	0	5	9
391	V:V:I105	V:V:Q101	2.74	No	Yes	0	4	9
392	V:V:P114	V:V:Q101	9.47	No	Yes	15	8	9
393	V:V:L104	V:V:L108	2.77	Yes	Yes	6	9	8
394	V:V:K107	V:V:L108	7.05	No	Yes	6	9	8
395	V:V:F115	V:V:F117	5.36	Yes	Yes	14	9	8
396	V:V:I119	V:V:P120	3.39	No	Yes	3	5	7
397	V:V:P120	V:V:P121	1.95	Yes	No	0	7	4
398	V:V:L123	V:V:P120	4.93	No	Yes	3	6	7
399	V:V:N122	V:V:P121	6.52	No	No	0	5	4
400	V:V:N122	V:V:R307	7.23	No	No	0	5	4
401	V:V:P124	V:V:V142	1.77	Yes	Yes	3	9	9
402	V:V:I314	V:V:P124	5.08	Yes	Yes	3	5	9
403	V:V:G316	V:V:P124	4.06	Yes	Yes	3	8	9
404	V:V:Q172	V:V:S125	7.22	No	No	3	9	7
405	V:V:S125	V:V:T304	3.2	No	No	3	7	9
406	V:V:E169	V:V:S126	2.87	Yes	No	1	9	9
407	V:V:G291	V:V:S126	3.71	No	No	1	9	9
408	V:V:I317	V:V:V127	6.14	Yes	No	0	8	8
409	V:V:G141	V:V:T128	1.82	No	No	0	9	6
410	V:V:K292	V:V:T128	6.01	No	No	0	6	6
411	V:V:I140	V:V:L129	2.85	No	No	0	9	8
412	V:V:P131	V:V:Q130	3.16	No	Yes	0	8	9
413	V:V:L278	V:V:Q130	3.99	No	Yes	0	8	9
414	V:V:L287	V:V:Q130	7.99	Yes	Yes	0	7	9
415	V:V:L289	V:V:Q130	11.98	No	Yes	0	9	9
416	V:V:G132	V:V:P133	4.06	No	No	12	6	4
417	V:V:G132	V:V:R285	4.5	No	Yes	12	6	7
418	V:V:P133	V:V:R285	2.88	No	Yes	12	4	7
419	V:V:G141	V:V:I140	1.76	No	No	0	9	9
420	V:V:G141	V:V:I317	1.76	No	Yes	0	9	8
421	V:V:V142	V:V:Y144	3.79	Yes	Yes	0	9	7
422	V:V:G316	V:V:V142	1.84	Yes	Yes	3	8	9
423	V:V:I317	V:V:V142	4.61	Yes	Yes	3	8	9
424	V:V:I168	V:V:Y144	3.63	No	Yes	0	8	7
425	V:V:K170	V:V:Y144	8.36	No	Yes	0	9	7
426	V:V:E145	V:V:R165	4.65	Yes	Yes	0	7	5
427	V:V:I168	V:V:V146	4.61	No	No	0	8	6
428	V:V:F149	V:V:K147	6.2	Yes	No	0	5	7
429	V:V:K147	V:V:R165	3.71	No	Yes	0	7	5
430	V:V:F149	V:V:I158	7.54	Yes	Yes	10	5	5
431	V:V:F149	V:V:S163	3.96	Yes	No	10	5	8
432	V:V:E156	V:V:N153	3.94	No	No	0	6	4
433	V:V:I158	V:V:N162	5.66	Yes	No	0	5	8
434	V:V:I158	V:V:S163	4.64	Yes	No	10	5	8
435	V:V:K160	V:V:R161	2.48	No	No	0	8	7
436	V:V:K160	V:V:R165	4.95	No	Yes	0	8	5
437	V:V:E169	V:V:V171	7.13	Yes	Yes	1	9	6
438	V:V:D290	V:V:E169	5.2	Yes	Yes	1	9	9
439	V:V:E169	V:V:G291	6.55	Yes	No	1	9	9
440	V:V:E169	V:V:L293	3.98	Yes	No	1	9	8
441	V:V:E169	V:V:H362	18.46	Yes	Yes	1	9	1
442	V:V:V171	V:V:Y173	3.79	Yes	Yes	1	6	4
443	V:V:D290	V:V:V171	4.38	Yes	Yes	1	9	6
444	V:V:Q172	V:V:T304	7.09	No	No	3	9	9
445	V:V:P356	V:V:Y173	15.3	No	Yes	0	9	4
446	V:V:A174	V:V:P175	1.87	No	No	0	9	9
447	V:V:A174	V:V:Y209	2.67	No	No	16	9	6
448	V:V:A174	V:V:P354	1.87	No	No	16	9	8
449	V:V:M352	V:V:P175	3.35	Yes	No	0	8	9
450	V:V:E176	V:V:K355	5.4	No	No	0	3	6
451	V:V:G179	V:V:P180	4.06	No	No	1	6	4
452	V:V:E206	V:V:G179	4.91	No	No	1	7	6
453	V:V:E206	V:V:P180	3.14	No	No	1	7	4
454	V:V:L203	V:V:P182	3.28	Yes	No	0	8	9
455	V:V:P182	V:V:P348	1.95	No	No	0	9	9
456	V:V:A184	V:V:V345	5.09	No	No	0	5	7
457	V:V:A184	V:V:L347	4.73	No	No	0	5	6
458	V:V:E185	V:V:H198	17.23	No	No	0	5	6
459	V:V:E185	V:V:E200	3.81	No	No	0	5	7
460	V:V:R188	V:V:T186	14.23	No	No	0	8	7
461	V:V:T186	V:V:V345	4.76	No	No	0	7	7
462	V:V:H198	V:V:T187	9.58	No	No	0	6	5
463	V:V:R188	V:V:V343	3.92	No	No	0	8	7
464	V:V:L197	V:V:L199	2.77	No	Yes	0	7	6
465	V:V:L197	V:V:N222	4.12	No	No	0	7	9
466	V:V:H198	V:V:T221	5.48	No	No	0	6	5
467	V:V:L199	V:V:V220	4.47	Yes	No	5	6	6
468	V:V:L199	V:V:L327	4.15	Yes	Yes	5	6	7
469	V:V:L199	V:V:V345	2.98	Yes	No	0	6	7
470	V:V:E200	V:V:H219	4.92	No	No	0	7	5
471	V:V:A201	V:V:L347	4.73	No	No	0	7	6
472	V:V:N217	V:V:S202	4.47	No	No	0	6	7
473	V:V:L203	V:V:Y208	5.86	Yes	Yes	1	8	6
474	V:V:I214	V:V:L203	2.85	Yes	Yes	1	8	8
475	V:V:L203	V:V:V216	2.98	Yes	No	0	8	7
476	V:V:L203	V:V:V323	4.47	Yes	No	1	8	7
477	V:V:L203	V:V:L347	4.15	Yes	No	0	8	6
478	V:V:D204	V:V:K205	11.06	No	No	0	6	8
479	V:V:K205	V:V:Y208	7.17	No	Yes	1	8	6
480	V:V:E212	V:V:K205	8.1	No	No	1	8	8
481	V:V:I207	V:V:Y209	4.84	No	No	0	5	6
482	V:V:E212	V:V:Y208	5.61	No	Yes	1	8	6
483	V:V:I214	V:V:Y208	10.88	Yes	Yes	1	8	6
484	V:V:F349	V:V:Y208	5.16	Yes	Yes	1	7	6
485	V:V:P354	V:V:Y209	16.69	No	No	16	8	6
486	V:V:H210	V:V:N299	5.1	Yes	No	1	9	8
487	V:V:H210	V:V:L300	2.57	Yes	Yes	1	9	9
488	V:V:H210	V:V:S302	5.58	Yes	No	1	9	9
489	V:V:H210	V:V:L351	9	Yes	No	0	9	8
490	V:V:H210	V:V:H353	23.88	Yes	Yes	1	9	8
491	V:V:G211	V:V:T275	1.82	No	Yes	0	8	4
492	V:V:E212	V:V:P213	3.14	No	No	0	8	4
493	V:V:P213	V:V:T275	5.25	No	Yes	0	4	4
494	V:V:I214	V:V:V235	3.07	Yes	Yes	1	8	8
495	V:V:I214	V:V:P276	5.08	Yes	Yes	0	8	9
496	V:V:F349	V:V:I214	2.51	Yes	Yes	1	7	8
497	V:V:I233	V:V:V216	3.07	Yes	No	0	5	7
498	V:V:I231	V:V:V218	3.07	Yes	Yes	5	6	7
499	V:V:I233	V:V:V218	3.07	Yes	Yes	5	5	7
500	V:V:K270	V:V:V218	3.04	Yes	Yes	5	8	7
501	V:V:V218	V:V:V325	4.81	Yes	No	5	7	8
502	V:V:H219	V:V:T221	2.74	No	No	0	5	5
503	V:V:H219	V:V:S269	9.76	No	No	0	5	5
504	V:V:L327	V:V:V220	2.98	Yes	No	5	7	6
505	V:V:N222	V:V:V262	2.96	No	Yes	0	9	7
506	V:V:K226	V:V:N225	8.39	No	No	0	8	5
507	V:V:P264	V:V:T227	5.25	No	No	0	5	5
508	V:V:V228	V:V:V262	3.21	No	Yes	0	8	7
509	V:V:L327	V:V:V228	5.96	Yes	No	0	7	8
510	V:V:K229	V:V:K230	5.75	No	No	0	8	5
511	V:V:K229	V:V:T261	6.01	No	No	0	8	5
512	V:V:K230	V:V:V328	4.55	No	No	0	5	4
513	V:V:I231	V:V:I233	2.94	Yes	Yes	5	6	5
514	V:V:D260	V:V:I231	8.4	Yes	Yes	5	6	6
515	V:V:I231	V:V:L327	2.85	Yes	Yes	5	6	7
516	V:V:K232	V:V:M255	8.64	No	No	3	6	3
517	V:V:E257	V:V:K232	17.55	No	No	3	6	6
518	V:V:K232	V:V:K326	14.37	No	Yes	0	6	7
519	V:V:E256	V:V:I233	8.2	Yes	Yes	5	4	5
520	V:V:I233	V:V:K270	2.91	Yes	Yes	5	5	8
521	V:V:I233	V:V:L274	2.85	Yes	No	5	5	5
522	V:V:I233	V:V:V325	7.68	Yes	No	5	5	8
523	V:V:R236	V:V:S234	3.95	Yes	No	3	5	5
524	V:V:M255	V:V:S234	4.6	No	No	3	3	5
525	V:V:K324	V:V:S234	4.59	Yes	No	3	6	5
526	V:V:V235	V:V:V253	3.21	Yes	Yes	1	8	9
527	V:V:V235	V:V:V323	3.21	Yes	No	1	8	7
528	V:V:F349	V:V:V235	2.62	Yes	Yes	1	7	8
529	V:V:K250	V:V:R236	13.61	No	Yes	0	5	5
530	V:V:K324	V:V:R236	12.38	Yes	Yes	3	6	5
531	V:V:E346	V:V:R236	5.82	Yes	Yes	3	8	5
532	V:V:Q237	V:V:V251	4.3	Yes	Yes	1	9	6
533	V:V:L287	V:V:Q237	3.99	Yes	Yes	1	7	9
534	V:V:A288	V:V:Q237	3.03	No	Yes	0	9	9
535	V:V:Q237	V:V:V319	4.3	Yes	No	0	9	8
536	V:V:Q237	V:V:Y321	16.91	Yes	Yes	0	9	9
537	V:V:D240	V:V:Y238	4.6	No	Yes	3	6	4
538	V:V:Q248	V:V:Y238	3.38	No	Yes	3	6	4
539	V:V:K250	V:V:Y238	8.36	No	Yes	0	5	4
540	V:V:S320	V:V:Y238	6.36	No	Yes	0	8	4
541	V:V:K322	V:V:Y238	11.94	No	Yes	3	5	4
542	V:V:E346	V:V:Y238	2.24	Yes	Yes	3	8	4
543	V:V:D240	V:V:Q248	5.22	No	No	3	6	6
544	V:V:D240	V:V:I318	5.6	No	Yes	3	6	5
545	V:V:A247	V:V:I241	3.25	No	No	0	8	8
546	V:V:I314	V:V:V242	3.07	Yes	No	3	5	6
547	V:V:G316	V:V:V242	1.84	Yes	No	3	8	6
548	V:V:I318	V:V:V242	3.07	Yes	No	3	5	6
549	V:V:F244	V:V:L243	6.09	Yes	Yes	3	8	7
550	V:V:P252	V:V:V251	1.77	No	Yes	0	4	6
551	V:V:L287	V:V:V251	2.98	Yes	Yes	1	7	6
552	V:V:P276	V:V:V253	3.53	Yes	Yes	0	9	9
553	V:V:N281	V:V:V253	2.96	Yes	Yes	1	9	9
554	V:V:L287	V:V:V253	2.98	Yes	Yes	1	7	9
555	V:V:L300	V:V:V253	2.98	Yes	Yes	1	9	9
556	V:V:A254	V:V:P276	1.87	No	Yes	0	7	9
557	V:V:E257	V:V:M255	6.77	No	No	3	6	3
558	V:V:A258	V:V:E256	3.02	No	Yes	0	5	4
559	V:V:E256	V:V:K270	4.05	Yes	Yes	5	4	8
560	V:V:E256	V:V:Y272	24.69	Yes	No	5	4	4
561	V:V:E256	V:V:L274	5.3	Yes	No	5	4	5
562	V:V:A258	V:V:D260	3.09	No	Yes	0	5	6
563	V:V:D260	V:V:F268	7.17	Yes	No	5	6	5
564	V:V:D260	V:V:K270	6.91	Yes	Yes	5	6	8
565	V:V:F268	V:V:V262	3.93	No	Yes	0	5	7
566	V:V:A263	V:V:P264	1.87	No	No	0	4	5
567	V:V:A263	V:V:S266	3.42	No	No	0	4	6
568	V:V:F268	V:V:K270	2.48	No	Yes	5	5	8
569	V:V:K270	V:V:Y272	7.17	Yes	No	5	8	4
570	V:V:T273	V:V:Y272	2.5	No	No	0	3	4
571	V:V:P276	V:V:T275	3.5	Yes	Yes	0	9	4
572	V:V:F277	V:V:T275	2.59	No	Yes	0	3	4
573	V:V:L351	V:V:P276	3.28	No	Yes	0	8	9
574	V:V:A279	V:V:F277	2.77	No	No	0	4	3
575	V:V:F277	V:V:N280	16.92	No	No	0	3	4
576	V:V:L278	V:V:R282	2.43	No	No	0	8	6
577	V:V:N280	V:V:N281	8.17	No	Yes	0	4	9
578	V:V:K284	V:V:N281	16.79	No	Yes	0	8	9
579	V:V:L287	V:V:N281	4.12	Yes	Yes	1	7	9
580	V:V:D297	V:V:R282	3.57	No	No	0	8	6
581	V:V:E283	V:V:K284	2.7	No	No	0	5	8
582	V:V:L287	V:V:L300	4.15	Yes	Yes	1	7	9
583	V:V:A288	V:V:A301	1.79	No	No	0	9	9
584	V:V:K292	V:V:L289	4.23	No	No	1	6	9
585	V:V:L289	V:V:T298	2.95	No	Yes	1	9	8
586	V:V:D290	V:V:G291	5.03	Yes	No	1	9	9
587	V:V:D290	V:V:T298	2.89	Yes	Yes	1	9	8
588	V:V:D290	V:V:N299	5.39	Yes	No	1	9	8
589	V:V:D290	V:V:H353	2.52	Yes	Yes	1	9	8
590	V:V:K292	V:V:T298	13.51	No	Yes	1	6	8
591	V:V:H362	V:V:L293	5.14	Yes	No	1	1	8
592	V:V:E296	V:V:T298	4.23	No	Yes	0	7	8
593	V:V:E296	V:V:E364	6.34	No	No	0	7	1
594	V:V:H353	V:V:N299	11.48	Yes	No	1	8	8
595	V:V:L300	V:V:Y321	3.52	Yes	Yes	0	9	9
596	V:V:A301	V:V:V319	3.39	No	No	0	9	8
597	V:V:M352	V:V:S302	3.07	Yes	No	1	8	9
598	V:V:H353	V:V:S302	2.79	Yes	No	1	8	9
599	V:V:S303	V:V:T350	6.4	No	No	1	8	4
600	V:V:M352	V:V:S303	4.6	Yes	No	1	8	8
601	V:V:L306	V:V:T304	2.95	Yes	No	3	4	9
602	V:V:L305	V:V:M352	4.24	No	Yes	0	5	8
603	V:V:I314	V:V:L306	2.85	Yes	Yes	3	5	4
604	V:V:I318	V:V:L306	2.85	Yes	Yes	3	5	4
605	V:V:E308	V:V:G309	3.27	No	No	0	3	4
606	V:V:G316	V:V:I314	1.76	Yes	Yes	3	8	5
607	V:V:I314	V:V:I318	7.36	Yes	Yes	3	5	5
608	V:V:F349	V:V:Y321	12.38	Yes	Yes	0	7	9
609	V:V:L351	V:V:Y321	14.07	No	Yes	0	8	9
610	V:V:E346	V:V:K322	9.45	Yes	No	3	8	5
611	V:V:K322	V:V:P348	5.02	No	No	0	5	9
612	V:V:F349	V:V:V323	5.24	Yes	No	1	7	7
613	V:V:K324	V:V:K326	4.31	Yes	Yes	0	6	7
614	V:V:A344	V:V:K324	3.21	No	Yes	0	4	6
615	V:V:E346	V:V:K324	8.1	Yes	Yes	3	8	6
616	V:V:K326	V:V:V328	3.04	Yes	No	0	7	4
617	V:V:D342	V:V:K326	6.91	No	Yes	0	7	7
618	V:V:L327	V:V:V343	2.98	Yes	No	0	7	7
619	V:V:M352	V:V:T350	3.01	Yes	No	1	8	4
620	V:V:E358	V:V:E359	5.07	No	No	0	1	1
621	V:V:P360	V:V:P361	1.95	Yes	No	0	1	1
622	V:V:H362	V:V:P360	13.73	Yes	Yes	1	1	1
623	V:V:P361	V:V:V365	1.77	No	No	0	1	1
624	V:V:E364	V:V:R363	5.82	No	No	17	1	1
625	V:V:E367	V:V:R363	3.49	No	No	17	1	1
626	V:V:E364	V:V:E367	3.81	No	No	17	1	1
627	V:V:P366	V:V:V365	5.3	No	No	0	1	1
628	R:R:A48	R:R:S297	1.71	No	No	0	6	8
629	V:V:G109	V:V:L108	1.71	No	Yes	0	9	8
630	V:V:G16	V:V:N15	1.7	No	No	0	5	8
631	V:V:A112	V:V:V40	1.7	No	No	0	8	8
632	V:V:A148	V:V:V41	1.7	No	No	0	6	5
633	V:V:A148	V:V:V55	1.7	No	No	0	6	8
634	V:V:A148	V:V:V164	1.7	No	No	0	6	8
635	V:V:I207	V:V:P178	1.69	No	No	0	5	4
636	V:V:A12	V:V:T19	1.68	No	No	0	5	7
637	V:V:A139	V:V:T128	1.68	No	No	0	5	6
638	V:V:K95	V:V:P96	1.67	No	No	0	3	3
639	V:V:K355	V:V:P356	1.67	No	No	0	6	9
640	R:R:L90	R:R:P91	1.64	Yes	No	0	7	9
641	R:R:A112	R:R:K111	1.61	No	No	0	4	7
642	R:R:A1366	V:V:K106	1.61	No	No	0	7	6
643	V:V:D44	V:V:P45	1.61	Yes	No	0	8	4
644	R:R:V252	R:R:V253	1.6	No	No	0	7	5
645	R:R:V253	R:R:V257	1.6	No	No	0	5	5
646	V:V:S202	V:V:T183	1.6	No	No	0	7	4
647	R:R:C228	R:R:L229	1.59	No	No	0	4	7
648	R:R:T260	R:R:V256	1.59	No	No	0	5	5
649	R:R:C298	R:R:L299	1.59	No	No	0	7	7
650	V:V:T227	V:V:V262	1.59	No	Yes	0	5	7
651	V:V:P182	V:V:Q181	1.58	No	No	0	9	7
652	R:R:C258	R:R:N296	1.57	Yes	No	0	7	9
653	V:V:E359	V:V:P360	1.57	No	Yes	0	1	1
654	R:R:A123	R:R:N120	1.56	No	Yes	0	6	8
655	V:V:A310	V:V:N122	1.56	No	No	0	4	5
656	R:R:I272	R:R:S276	1.55	No	No	0	2	3
657	R:R:A80	R:R:D83	1.54	No	No	0	8	9
658	R:R:I213	R:R:V209	1.54	No	No	0	4	2
659	R:R:M222	R:R:S132	1.53	No	No	0	8	9
660	R:R:F65	R:R:G64	1.51	No	No	0	4	3
661	R:R:K152	R:R:T150	1.5	No	No	0	5	6
662	R:R:L219	R:R:S223	1.5	No	No	0	6	3
663	R:R:L220	R:R:S223	1.5	No	No	0	4	3
664	V:V:G64	V:V:R62	1.5	No	No	0	9	8
665	V:V:N217	V:V:V271	1.48	No	No	0	6	5
666	R:R:L270	R:R:T271	1.47	No	No	0	5	4
667	V:V:D204	V:V:S215	1.47	No	No	0	6	4
668	V:V:N225	V:V:T224	1.46	No	No	0	5	9
669	V:V:N245	V:V:T246	1.46	No	No	0	8	7
670	V:V:P178	V:V:R177	1.44	No	No	0	4	3
671	R:R:I156	R:R:L155	1.43	No	No	0	3	4
672	V:V:E145	V:V:V167	1.43	Yes	No	0	7	5
673	R:R:K69	R:R:L74	1.41	No	No	0	7	6
674	V:V:K95	V:V:L97	1.41	No	Yes	0	3	4
675	V:V:E206	V:V:T350	1.41	No	No	1	7	4
676	V:V:A151	V:V:F149	1.39	No	Yes	0	6	5
677	R:R:L155	R:R:L74	1.38	No	No	0	4	6
678	V:V:A60	V:V:R76	1.38	No	No	0	8	8
679	R:R:I272	R:R:Q283	1.37	No	No	0	2	3
680	V:V:E156	V:V:I158	1.37	No	Yes	0	6	5
681	V:V:L306	V:V:N311	1.37	Yes	No	0	4	4
682	L:L:A155	R:R:Y96	1.33	No	Yes	0	9	6
683	R:R:H273	R:R:I272	1.33	Yes	No	0	3	2
684	V:V:A239	V:V:Y249	1.33	No	No	0	8	7
685	V:V:E313	V:V:L315	1.33	No	No	0	7	5
686	L:L:F150	L:L:S147	1.32	No	No	0	4	3
687	V:V:H295	V:V:K294	1.31	No	No	0	7	9
688	V:V:E367	V:V:N368	1.31	No	No	0	1	1
689	V:V:D44	V:V:E46	1.3	Yes	No	0	8	3
690	V:V:D143	V:V:E145	1.3	No	Yes	0	7	7
691	R:R:H138	R:R:L139	1.29	No	No	0	8	8
692	R:R:H138	R:R:L144	1.29	No	No	0	8	5
693	R:R:H203	R:R:L206	1.29	No	Yes	8	4	5
694	V:V:R99	V:V:T98	1.29	No	No	0	4	8
695	L:L:Y149	R:R:S278	1.27	No	No	0	5	2
696	R:R:I201	R:R:R202	1.25	No	No	0	1	1
697	R:R:F62	R:R:L77	1.22	No	No	0	7	6
698	R:R:F191	R:R:Q192	1.17	Yes	No	0	5	4
699	V:V:E50	V:V:R51	1.16	No	Yes	0	4	6
700	V:V:E313	V:V:R312	1.16	No	No	0	7	4
701	L:L:F148	R:R:H279	1.13	No	No	0	1	1
702	R:R:F175	R:R:Y174	1.03	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F154	6.172	5	2	6
2	L:L:F156	8.27	4	2	9
3	R:R:W75	7.545	6	4	7
4	R:R:L79	8.626	5	4	9
5	R:R:L87	6.308	5	9	6
6	R:R:F89	6.83	4	11	6
7	R:R:L90	5.6075	4	9	7
8	R:R:L92	9.335	4	2	6
9	R:R:Y93	7.312	5	2	6
10	R:R:Y96	2.7	5	2	6
11	R:R:W103	14.1267	6	2	9
12	R:R:L109	11.94	5	2	5
13	R:R:C110	3.8	4	2	9
14	R:R:N120	6.2925	4	11	8
15	R:R:M121	5.166	5	2	7
16	R:R:F122	7.0025	4	2	6
17	R:R:F126	5.615	4	0	5
18	R:R:F127	8.045	6	4	7
19	R:R:T129	3.75	4	0	7
20	R:R:I131	6.08	5	4	8
21	R:R:H141	13.148	5	3	6
22	R:R:P142	6.2625	4	3	8
23	R:R:H148	7.722	5	4	3
24	R:R:S154	5.7875	4	4	7
25	R:R:R176	6.636	5	2	4
26	R:R:T178	3.8175	4	2	5
27	R:R:Y188	6.435	4	0	3
28	R:R:F191	4.0225	4	2	5
29	R:R:L206	2.7025	4	8	5
30	R:R:Y215	8.598	5	2	8
31	R:R:F255	7.8	5	2	9
32	R:R:C258	3.2125	4	2	7
33	R:R:W259	6.84375	8	2	8
34	R:R:Y262	8.215	4	2	6
35	R:R:H263	8.1175	4	2	8
36	R:R:H273	4.91	5	8	3
37	R:R:I286	6.415	4	2	4
38	R:R:F294	5.544	5	2	7
39	R:R:N300	6.67	4	4	9
40	R:R:Y304	9.53167	6	4	9
41	R:R:?1360	10.0967	6	1	6
42	R:R:?1362	11.275	4	6	4
43	R:R:?1363	12.8733	6	6	7
44	R:R:L1365	6.414	5	6	5
45	V:V:K11	7.5725	4	1	9
46	V:V:K17	12.1375	4	7	5
47	V:V:Y21	4.60667	6	6	8
48	V:V:R25	8.26	4	1	9
49	V:V:D26	8.034	5	1	9
50	V:V:V43	5.255	4	7	6
51	V:V:D44	5.335	4	7	8
52	V:V:Y47	9.544	5	7	5
53	V:V:L48	4.1975	4	7	4
54	V:V:R51	4.7475	4	7	6
55	V:V:V53	4.09833	6	7	7
56	V:V:F61	4.2725	4	3	9
57	V:V:F80	4.05	4	3	4
58	V:V:F87	6.37	4	7	4
59	V:V:L97	4.495	4	15	4
60	V:V:Q101	5.466	5	15	9
61	V:V:L104	3.896	5	6	9
62	V:V:L108	4.074	5	6	8
63	V:V:Y113	4.9825	4	7	3
64	V:V:F115	5.61	5	14	9
65	V:V:F117	7.59	5	14	8
66	V:V:P120	4.3725	4	3	7
67	V:V:P124	3.5475	4	3	9
68	V:V:Q130	6.78	4	0	9
69	V:V:V142	3.188	5	3	9
70	V:V:Y144	4.945	4	0	7
71	V:V:E145	2.55	4	0	7
72	V:V:F149	5.37667	6	10	5
73	V:V:V150	4.725	4	7	5
74	V:V:I158	4.8025	4	10	5
75	V:V:R165	5.3925	4	0	5
76	V:V:E169	6.68429	7	1	9
77	V:V:V171	4.92	4	1	6
78	V:V:Y173	7.7325	4	1	4
79	V:V:L199	3.5925	4	5	6
80	V:V:L203	3.93167	6	1	8
81	V:V:Y208	6.936	5	1	6
82	V:V:H210	9.226	5	1	9
83	V:V:I214	4.878	5	1	8
84	V:V:V218	3.4975	4	5	7
85	V:V:I231	4.315	4	5	6
86	V:V:I233	4.38857	7	5	5
87	V:V:V235	3.0275	4	1	8
88	V:V:R236	8.94	4	3	5
89	V:V:Q237	6.506	5	1	9
90	V:V:Y238	6.14667	6	3	4
91	V:V:L243	6.218	5	3	7
92	V:V:F244	8.9125	4	3	8
93	V:V:V251	3.9925	4	1	6
94	V:V:V253	3.132	5	1	9
95	V:V:E256	9.052	5	5	4
96	V:V:D260	6.3925	4	5	6
97	V:V:V262	2.9225	4	0	7
98	V:V:K270	4.42667	6	5	8
99	V:V:T275	3.29	4	0	4
100	V:V:P276	3.452	5	0	9
101	V:V:N281	8.01	4	1	9
102	V:V:R285	5.8025	4	12	7
103	V:V:L287	4.36833	6	1	7
104	V:V:D290	4.235	6	1	9
105	V:V:T298	5.895	4	1	8
106	V:V:L300	3.305	4	1	9
107	V:V:L306	2.505	4	3	4
108	V:V:I314	4.024	5	3	5
109	V:V:G316	2.804	5	3	8
110	V:V:I317	4.07	4	3	8
111	V:V:I318	4.72	4	3	5
112	V:V:Y321	11.72	4	0	9
113	V:V:K324	6.518	5	3	6
114	V:V:K326	7.1575	4	0	7
115	V:V:L327	3.784	5	5	7
116	V:V:E346	6.4025	4	3	8
117	V:V:F349	5.582	5	1	7
118	V:V:M352	3.654	5	1	8
119	V:V:H353	10.1675	4	1	8
120	V:V:P360	7.13	4	1	1
121	V:V:H362	12.8	4	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H203	R:R:H273	12.7958	7.17	No	Yes	8	4	3
2	R:R:H203	R:R:L206	15.6328	1.29	No	Yes	8	4	5
3	L:L:Q153	R:R:L206	18.4283	2.66	No	Yes	8	6	5
4	L:L:Q153	R:R:N190	20.5459	7.92	No	No	0	6	3
5	R:R:D177	R:R:N190	23.1912	13.46	No	No	0	5	3
6	R:R:D177	R:R:Y188	32.0845	3.45	No	Yes	0	5	3
7	R:R:Y188	R:R:Y96	38.2314	2.98	Yes	Yes	0	3	6
8	R:R:Y93	R:R:Y96	40.0184	2.98	Yes	Yes	2	6	6
9	L:L:F156	R:R:Y93	75.0945	16.5	Yes	Yes	2	9	6
10	L:L:F156	R:R:M121	48.8157	7.46	Yes	Yes	2	9	7
11	L:L:F156	R:R:Y262	26.9001	5.16	Yes	Yes	2	9	6
12	R:R:M121	R:R:W259	27.5764	4.65	Yes	Yes	2	7	8
13	R:R:F255	R:R:W259	57.2535	16.04	Yes	Yes	2	9	8
14	R:R:F255	R:R:L128	61.737	7.31	Yes	No	0	9	9
15	R:R:I131	R:R:L128	61.8814	2.85	Yes	No	0	8	9
16	R:R:L79	R:R:N300	11.7567	6.87	Yes	Yes	4	9	9
17	R:R:N300	R:R:P301	13.6569	9.77	Yes	No	4	9	9
18	R:R:G55	R:R:P301	13.3196	2.03	No	No	0	7	9
19	R:R:G55	R:R:P54	12.5783	2.03	No	No	0	7	4
20	R:R:I53	R:R:P54	11.8346	5.08	No	No	0	6	4
21	R:R:W259	R:R:Y262	27.3829	2.89	Yes	Yes	2	8	6
22	R:R:T290	R:R:Y93	14.9412	7.49	No	Yes	2	6	6
23	R:R:F127	R:R:I131	54.8976	7.54	Yes	Yes	4	7	8
24	R:R:F127	R:R:W75	67.198	4.01	Yes	Yes	4	7	7
25	R:R:F122	R:R:M121	22.4776	2.49	Yes	Yes	2	6	7
26	R:R:F122	R:R:I168	23.0198	7.54	Yes	No	0	6	5
27	R:R:I168	R:R:I213	24.5144	4.42	No	No	0	5	4
28	R:R:F126	R:R:I213	24.9018	2.51	Yes	No	0	5	4
29	R:R:F126	R:R:I161	27.3992	5.02	Yes	No	0	5	7
30	R:R:I161	R:R:V157	29.8556	3.07	No	No	0	7	6
31	R:R:H148	R:R:V157	29.9699	5.54	Yes	No	0	3	6
32	R:R:H148	R:R:W75	66.8598	10.58	Yes	Yes	4	3	7
33	R:R:C110	R:R:L109	13.2291	3.17	Yes	Yes	2	9	5
34	R:R:L109	R:R:L92	14.5209	4.15	Yes	Yes	2	5	6
35	R:R:L92	R:R:Y93	18.6822	2.34	Yes	Yes	2	6	6
36	R:R:H148	R:R:N153	99.5776	12.75	Yes	No	0	3	4
37	R:R:N153	R:R:T150	99.6137	2.92	No	No	0	4	6
38	R:R:T150	V:V:R285	99.6841	5.17	No	Yes	0	6	7
39	R:R:R149	V:V:R285	99.7852	10.66	No	Yes	0	7	7
40	R:R:R149	V:V:I140	99.9116	3.76	No	No	0	7	9
41	V:V:G141	V:V:I140	100	1.76	No	No	0	9	9
42	V:V:G141	V:V:I317	47.4935	1.76	No	Yes	0	9	8
43	V:V:F61	V:V:I317	15.5287	3.77	Yes	Yes	3	9	8
44	V:V:G141	V:V:T128	58.5369	1.82	No	No	0	9	6
45	V:V:K292	V:V:T128	58.2818	6.01	No	No	0	6	6
46	V:V:K292	V:V:L289	29.8896	4.23	No	No	1	6	9
47	V:V:L289	V:V:Q130	31.2753	11.98	No	Yes	0	9	9
48	V:V:L287	V:V:Q130	30.4705	7.99	Yes	Yes	0	7	9
49	V:V:K292	V:V:T298	28.287	13.51	No	Yes	1	6	8
50	V:V:D290	V:V:T298	28.762	2.89	Yes	Yes	1	9	8
51	V:V:D290	V:V:E169	32.7849	5.2	Yes	Yes	1	9	9
52	V:V:E169	V:V:L293	29.6311	3.98	Yes	No	1	9	8
53	V:V:L293	V:V:R25	30.2623	6.07	No	Yes	1	8	9
54	R:R:?1360	V:V:R25	19.7375	12.97	Yes	Yes	1	6	9
55	R:R:?1357	V:V:K11	13.4544	2.4	No	Yes	0	6	9
56	V:V:L166	V:V:R25	10.4884	9.72	No	Yes	0	8	9
57	R:R:?1357	V:V:R165	12.8034	8.26	No	Yes	0	6	5
58	R:R:?1360	R:R:A1361	10.5985	2.59	Yes	No	0	6	7
59	R:R:?1362	R:R:A1361	10.2784	4.02	Yes	No	0	4	7
60	V:V:I317	V:V:V142	31.7461	4.61	Yes	Yes	3	8	9
61	V:V:V142	V:V:Y144	16.6876	3.79	Yes	Yes	0	9	7
62	V:V:I168	V:V:Y144	13.7962	3.63	No	Yes	0	8	7
63	V:V:F27	V:V:I168	13.3389	7.54	No	No	0	8	8
64	V:V:F27	V:V:V37	12.9258	13.11	No	No	0	8	8
65	V:V:F117	V:V:V37	12.7513	5.24	Yes	No	0	8	8
66	V:V:F61	V:V:G316	12.8211	4.52	Yes	Yes	3	9	8
67	V:V:G316	V:V:V142	14.208	1.84	Yes	Yes	3	8	9
68	V:V:G316	V:V:I314	14.119	1.76	Yes	Yes	3	8	5
69	V:V:D290	V:V:H353	10.9754	2.52	Yes	Yes	1	9	8
70	V:V:L287	V:V:V253	24.481	2.98	Yes	Yes	1	7	9
71	V:V:V235	V:V:V253	16.1136	3.21	Yes	Yes	1	8	9
72	V:V:I214	V:V:L203	20.5748	2.85	Yes	Yes	1	8	8
73	V:V:I214	V:V:P276	15.2634	5.08	Yes	Yes	0	8	9
74	V:V:G316	V:V:V242	12.5007	1.84	Yes	No	3	8	6
75	V:V:I318	V:V:V242	12.0982	3.07	Yes	No	3	5	6
76	V:V:D240	V:V:I318	30.1305	5.6	No	Yes	3	6	5
77	V:V:D240	V:V:Y238	28.1104	4.6	No	Yes	3	6	4
78	V:V:I314	V:V:I318	18.5585	7.36	Yes	Yes	3	5	5
79	V:V:L203	V:V:V216	17.7336	2.98	Yes	No	0	8	7
80	V:V:I233	V:V:V216	17.0591	3.07	Yes	No	0	5	7
81	V:V:H210	V:V:L351	10.3042	9	Yes	No	0	9	8
82	V:V:E346	V:V:Y238	16.6464	2.24	Yes	Yes	3	8	4
83	V:V:E346	V:V:K324	13.7546	8.1	Yes	Yes	3	8	6
84	L:L:F154	R:R:R176	11.1358	2.14	Yes	Yes	2	6	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F148	R:R:H280	5.66	0	No	No	1	3	0	1
L:L:Y149	R:R:H280	2.18	0	No	No	5	3	0	1
L:L:Y149	R:R:M282	14.37	0	No	No	5	4	0	1
L:L:P151	R:R:Y277	5.56	0	No	No	9	1	0	1
L:L:G152	R:R:Y188	2.9	0	No	Yes	9	3	0	1
L:L:Q153	R:R:F175	2.34	8	No	No	6	4	0	1
L:L:Q153	R:R:N190	7.92	8	No	No	6	3	0	1
L:L:Q153	R:R:L206	2.66	8	No	Yes	6	5	0	1
L:L:F154	R:R:C110	2.79	2	Yes	Yes	6	9	0	1
L:L:F154	R:R:K111	2.48	2	Yes	No	6	7	0	1
L:L:F154	R:R:S114	7.93	2	Yes	No	6	5	0	1
L:L:F154	R:R:R176	2.14	2	Yes	Yes	6	4	0	1
L:L:F154	R:R:D177	15.52	2	Yes	No	6	5	0	1
L:L:F156	R:R:Y93	16.5	2	Yes	Yes	9	6	0	1
L:L:F156	R:R:M121	7.46	2	Yes	Yes	9	7	0	1
L:L:F156	R:R:Y262	5.16	2	Yes	Yes	9	6	0	1
L:L:F156	R:R:S289	3.96	2	Yes	No	9	7	0	1
R:R:L92	R:R:Y93	2.34	2	Yes	Yes	6	6	2	1
R:R:L109	R:R:L92	4.15	2	Yes	Yes	5	6	2	2
R:R:Y93	R:R:Y96	2.98	2	Yes	Yes	6	6	1	1
R:R:I286	R:R:Y93	7.25	2	Yes	Yes	4	6	2	1
R:R:T290	R:R:Y93	7.49	2	No	Yes	6	6	2	1
R:R:V97	R:R:Y96	3.79	2	No	Yes	5	6	2	1
R:R:Y188	R:R:Y96	2.98	0	Yes	Yes	3	6	1	1
R:R:I286	R:R:Y96	2.42	2	Yes	Yes	4	6	2	1
R:R:I286	R:R:V97	9.22	2	Yes	No	4	5	2	2
R:R:C110	R:R:G106	1.96	2	Yes	No	9	7	1	2
R:R:C187	R:R:G106	1.96	2	No	No	9	7	2	2
R:R:C110	R:R:L109	3.17	2	Yes	Yes	9	5	1	2
R:R:C110	R:R:C187	7.28	2	Yes	No	9	9	1	2
R:R:K111	R:R:R176	13.61	2	No	Yes	7	4	1	1
R:R:M121	R:R:Q118	8.16	2	Yes	No	7	5	1	2
R:R:F122	R:R:Q118	10.54	2	Yes	No	6	5	2	2
R:R:F122	R:R:M121	2.49	2	Yes	Yes	6	7	2	1
R:R:M121	R:R:S124	3.07	2	Yes	No	7	9	1	2
R:R:M121	R:R:W259	4.65	2	Yes	Yes	7	8	1	2
R:R:F122	R:R:K210	7.44	2	Yes	No	6	6	2	2
R:R:F175	R:R:L206	2.44	8	No	Yes	4	5	1	1
R:R:R176	R:R:T178	5.17	2	Yes	Yes	4	5	1	2
R:R:F191	R:R:R176	8.55	2	Yes	Yes	5	4	2	1
R:R:K193	R:R:R176	3.71	2	No	Yes	2	4	2	1
R:R:D177	R:R:Y188	3.45	0	No	Yes	5	3	1	1
R:R:D177	R:R:N190	13.46	0	No	No	5	3	1	1
R:R:F191	R:R:T178	3.89	2	Yes	Yes	5	5	2	2
R:R:L186	R:R:Y188	16.41	0	No	Yes	3	3	2	1
R:R:K193	R:R:N190	15.39	2	No	No	2	3	2	1
R:R:F191	R:R:K193	2.48	2	Yes	No	5	2	2	2
R:R:H203	R:R:H273	7.17	8	No	Yes	4	3	2	2
R:R:L206	R:R:T207	4.42	8	Yes	No	5	5	1	2
R:R:K210	R:R:Y262	9.55	0	No	Yes	6	6	2	1
R:R:W259	R:R:Y262	2.89	2	Yes	Yes	8	6	2	1
R:R:S289	R:R:Y262	15.26	2	No	Yes	7	6	1	1
R:R:H273	R:R:Y277	9.8	8	Yes	No	3	1	2	1
R:R:Q283	R:R:S278	7.22	0	No	No	3	2	2	1
R:R:A284	R:R:M282	4.83	0	No	No	2	4	2	1
R:R:A112	R:R:K111	1.61	0	No	No	4	7	2	1
L:L:A155	R:R:Y96	1.33	0	No	Yes	9	6	0	1
R:R:H203	R:R:L206	1.29	8	No	Yes	4	5	2	1
L:L:Y149	R:R:S278	1.27	0	No	No	5	2	0	1
L:L:F148	R:R:H279	1.13	0	No	No	1	1	0	1
R:R:F175	R:R:Y174	1.03	8	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9UYL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.76
Number of Linked Nodes	551
Number of Links	702
Number of Hubs	121
Number of Links mediated by Hubs	417
Number of Communities	17
Number of Nodes involved in Communities	209
Number of Links involved in Communities	309

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	516133
Length Of Smallest Path	3
Average Path Length	24.1051
Length of Longest Path	49
Minimum Path Strength	1.245
Average Path Strength	5.92761
Maximum Path Strength	27.79
Minimum Path Correlation	0.7
Average Path Correlation	0.970799
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.9585
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.9519
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• vasopressin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • binding • adipokinetic hormone binding • peptide hormone binding • hormone binding • protein-hormone receptor activity • adipokinetic hormone receptor activity • neuropeptide binding • peptide binding • regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation
Gene Ontology	Biological Process	• regulation of body fluid levels • hemostasis • biological regulation • regulation of biological quality • regulation of tube diameter • multicellular organismal process • regulation of biological process • system process • regulation of tube size • regulation of system process • positive regulation of biological process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • renal system process • transport • homeostatic process • fluid transport • establishment of localization • water transport • renal water transport • localization • multicellular organismal-level homeostasis • chemical homeostasis • renal absorption • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water absorption • renal water homeostasis • regulation of biosynthetic process • regulation of cellular process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • response to peptide • response to cytokine • regulation of systemic arterial blood pressure by hormone • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of systemic arterial blood pressure • endocrine process • regulation of systemic arterial blood pressure by vasopressin • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • positive regulation of intracellular signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • regulation of urine volume • renal water retention • negative regulation of urine volume • developmental process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • telencephalon development • system development • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • positive regulation of systemic arterial blood pressure • positive regulation of blood pressure • neuropeptide signaling pathway • glucose homeostasis • carbohydrate homeostasis • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular organelle • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • intracellular membrane-bounded organelle • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle • cytoplasm • organelle membrane • cell periphery • plasma membrane • Golgi apparatus • endomembrane system • endosome • perinuclear region of cytoplasm • endoplasmic reticulum • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • signaling receptor binding • humoral immune response • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • immune response • defense response to symbiont • response to external stimulus • antimicrobial humoral response • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • immune system process • antifungal humoral response • response to external biotic stimulus • response to fungus • developmental process • cellular developmental process • cell differentiation • cellular process • chemotaxis • positive regulation of locomotion • regulation of biological process • regulation of response to external stimulus • biological regulation • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • response to activity • multicellular organismal process • digestive system development • tube development • animal organ development • embryo development • digestive tract development • multicellular organism development • anatomical structure development • embryonic organ development • embryonic digestive tract development • system development • innate immune response • lipid catabolic process • catabolic process • regulation of cellular process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • response to nutrient levels • response to caloric restriction • cellular response to stimulus • regulation of cell motility • macrophage migration • positive regulation of cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • antifungal innate immune response • cellular response to nitrogen compound • signaling • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cell communication • cellular response to endogenous stimulus • response to hormone • signal transduction • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • macromolecule metabolic process • inflammatory response • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • positive regulation of systemic arterial blood pressure • system process • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • regulation of biological quality • blood circulation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • vesicle lumen • cytoplasmic vesicle lumen • secretory granule lumen • platelet dense granule lumen • platelet dense granule • secretory granule • secretory vesicle • extracellular matrix • external encapsulating structure • extracellular region • extracellular space • arrestin family protein binding • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • angiotensin receptor binding • G protein-coupled receptor binding • molecular adaptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • insulin-like growth factor receptor binding • molecular function inhibitor activity • enzyme inhibitor activity • transcription coactivator activity • transcription regulator activity • transcription coregulator activity • protein-macromolecule adaptor activity • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • interleukin-6 production • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • negative regulation of cytokine production • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of interleukin-6 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process • negative regulation of post-translational protein modification • regulation of protein ubiquitination • protein ubiquitination • negative regulation of protein modification process • negative regulation of protein ubiquitination • regulation of protein modification by small protein conjugation or removal • negative regulation of protein metabolic process • negative regulation of protein modification by small protein conjugation or removal • regulation of post-translational protein modification • post-translational protein modification • protein modification by small protein conjugation • protein modification by small protein conjugation or removal • actomyosin structure organization • actin cytoskeleton organization • actin filament organization • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • actin filament bundle organization • contractile actin filament bundle assembly • actin filament-based process • actin filament bundle assembly • stress fiber assembly • cellular component organization or biogenesis • supramolecular fiber organization • cytoskeleton organization • negative adaptation of signaling pathway • negative regulation of signaling • desensitization of G protein-coupled receptor signaling pathway • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • adaptation of signaling pathway • regulation of cell communication • G protein-coupled receptor signaling pathway • sensory perception • nervous system process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • muscle hypertrophy • regulation of muscle adaptation • positive regulation of cardiac muscle hypertrophy • regulation of system process • striated muscle hypertrophy • regulation of muscle system process • muscle system process • regulation of cardiac muscle hypertrophy • regulation of muscle hypertrophy • muscle adaptation • positive regulation of muscle hypertrophy • cardiac muscle hypertrophy • positive regulation of multicellular organismal process • negative regulation of interleukin-8 production • interleukin-8 production • regulation of interleukin-8 production • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • import into cell • receptor internalization • transport • vesicle-mediated transport • localization • G protein-coupled receptor internalization • establishment of localization • receptor-mediated endocytosis • endocytosis • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • establishment of protein localization • protein transport • macromolecule localization • intracellular protein localization • regulation of localization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of receptor internalization • positive regulation of endocytosis • positive regulation of receptor-mediated endocytosis • regulation of endocytosis • regulation of transport • regulation of receptor-mediated endocytosis • regulation of vesicle-mediated transport • positive regulation of receptor internalization • positive regulation of transport • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • positive regulation of small GTPase mediated signal transduction • proteasomal protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • Notch signaling pathway • negative regulation of Notch signaling pathway • regulation of Notch signaling pathway • pseudopodium • clathrin-coated pit • cytosol • membraneless organelle • intracellular membraneless organelle • chromatin • chromosome • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi membrane • nuclear body
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SEP
PDB Residues	R:R:?1357 R:R:?1362 R:R:?1363 R:R:?1364
Environment Details	Open EMBL-EBI Page
Code	SEP
Name	Dexfosfoserine
Synonyms	PHOSPHONOSERINE
Identifier
Formula	C3 H8 N O6 P
Molecular Weight	185.072
SMILES
PubChem	57689797
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	TPO
PDB Residues	R:R:?1359 R:R:?1360
Environment Details	Open EMBL-EBI Page
Code	TPO
Name	PHOSPHOTHREONINE
Synonyms	PHOSPHONOTHREONINE
Identifier
Formula	C4 H10 N O6 P
Molecular Weight	199.099
SMILES
PubChem	139055008
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	2
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Chemerin-9
UniProt	Q99969
Sequence	>9UYL_nogp_Chain_L S F Y F P G Q F A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P46091
Sequence	>9UYL_nogp_Chain_R L V L Y C L A F V L G I P G N A I V I W F T G F K W K K T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N F H W P F G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H P V L S H R H R T L K N S L I V I I F I W L L A S L I G G P A L Y F R D T V E F N N H T L C Y N N F Q K H I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I V V A F V V C W T P Y H L F S I W E L T I H H N S Y S H H V M Q A G I P L S T G L A F L N S C L N P I L Y ?C ??A ?? ?L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P49407
Sequence	>9UYL_nogp_Chain_V T R V F K K A S P N G K L T V Y L G K R D F V D H I D L V D P V D G V V L V D P E Y L K E R R V Y V T L T A F R Y G F R K D L F V A N V Q S F P K P L T R L Q E R L I K K L G E H A Y P F T F E I P P N L P S V T L Q P G P E A G V D Y E V K A F A E N L E E K I H K R N S V R L V I K V Q Y A P E R P G P Q P T A E T T R Q L H L E A S L D K E I Y Y H G E P I S V N V H V T N N T N K T V K K I K I S V R Q Y A D I L F N T A Q Y K P V A M E E A D D T V A P S S T F K V Y T L T P F L A N N R E K R G L A L D G K L K H E D T N L A S S T L L R E G A N R E I L G I I V S Y K V K V K L V D V A V E L P F T L M H P K P K E E P P H R E V P E N A S I V E V V S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JJP	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8JJP (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		2.9	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	8XGM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.29	2024-08-21	doi.org/10.1371/journal.pbio.3002838
	9L3Y	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Y (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin	-		3.6	2025-03-12	doi.org/10.1093/procel/pwae073
	9UYH	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYH (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYI	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.2	2025-11-19	10.1126/science.adt8794
	9UYI (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.2	2025-11-19	10.1126/science.adt8794
	9UYJ	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYJ (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYL	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	Arrestin2	3.3	2025-11-19	10.1126/science.adt8794
	9UYL (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.3	2025-11-19	10.1126/science.adt8794
	9UYM	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-	chim(Arrestin3-CtArrestin2)	3.5	2025-11-19	10.1126/science.adt8794
	9UYM (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	Chemerin-9	-		3.5	2025-11-19	10.1126/science.adt8794
	9UYN	A	Protein	Chemerin	CML2	Homo sapiens	-	-	Arrestin2	2.9	2025-11-19	10.1126/science.adt8794
	9UYN (No Gprot)	A	Protein	Chemerin	CML2	Homo sapiens	-	-		2.9	2025-11-19	10.1126/science.adt8794

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