psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L28	R:R:P29	4.93	No	No	0	5	5
2	R:R:P286	R:R:P29	5.84	No	No	0	6	5
3	R:R:L33	R:R:S289	4.5	Yes	No	0	7	5
4	R:R:F292	R:R:L33	7.31	Yes	Yes	0	7	7
5	R:R:F293	R:R:T36	6.49	No	No	0	5	7
6	R:R:F37	R:R:V38	3.93	Yes	No	0	6	5
7	R:R:F37	R:R:V41	3.93	Yes	No	0	6	6
8	R:R:F37	R:R:L78	3.65	Yes	No	0	6	8
9	R:R:F37	R:R:P79	5.78	Yes	No	0	6	8
10	R:R:C296	R:R:L39	4.76	No	No	0	8	5
11	R:R:G40	R:R:T75	3.64	No	No	0	8	7
12	R:R:G43	R:R:P299	4.06	No	No	0	8	9
13	R:R:D71	R:R:N44	13.46	No	No	0	9	9
14	R:R:F72	R:R:N44	6.04	No	No	0	7	9
15	R:R:N44	R:R:P299	8.15	No	No	0	9	9
16	R:R:V303	R:R:V47	6.41	No	No	1	7	9
17	R:R:F309	R:R:V47	5.24	Yes	No	1	8	9
18	R:R:I48	R:R:L65	4.28	No	No	0	7	5
19	R:R:F72	R:R:I48	3.77	No	No	0	7	7
20	R:R:V50	R:R:W49	3.68	No	No	0	7	4
21	R:R:F309	R:R:V50	10.49	Yes	No	0	8	7
22	R:R:G52	R:R:L65	5.13	No	No	0	4	5
23	R:R:R54	R:R:S316	6.59	No	No	0	4	5
24	R:R:F309	R:R:M55	6.22	Yes	No	0	8	5
25	R:R:M55	R:R:R312	4.96	No	No	0	5	5
26	R:R:L65	R:R:R57	3.64	No	No	0	5	6
27	R:R:T58	R:R:T60	4.71	No	No	0	7	7
28	R:R:T58	R:R:T61	6.28	No	No	0	7	7
29	R:R:D122	R:R:V59	4.38	No	No	3	8	6
30	R:R:R137	R:R:V59	19.61	Yes	No	3	7	6
31	R:R:A142	R:R:V59	5.09	No	No	0	7	6
32	R:R:T60	R:R:Y64	3.75	No	Yes	0	7	8
33	R:R:R137	R:R:T60	5.17	Yes	No	0	7	7
34	R:R:I62	R:R:V139	4.61	No	No	0	7	3
35	R:R:I62	R:R:M143	4.37	No	No	0	7	4
36	R:R:I119	R:R:Y64	3.63	Yes	Yes	1	9	8
37	R:R:R123	R:R:Y64	7.2	Yes	Yes	1	9	8
38	R:R:V303	R:R:Y64	7.57	No	Yes	1	7	8
39	R:R:I146	R:R:N66	11.33	Yes	No	0	7	9
40	R:R:N66	R:R:W150	5.65	No	No	0	9	9
41	R:R:L115	R:R:L67	4.15	No	Yes	0	8	9
42	R:R:I116	R:R:L67	4.28	Yes	Yes	1	8	9
43	R:R:I119	R:R:L67	4.28	Yes	Yes	1	9	9
44	R:R:L67	R:R:N298	8.24	Yes	Yes	1	9	9
45	R:R:D71	R:R:N298	6.73	No	Yes	0	9	9
46	R:R:N108	R:R:S73	10.43	Yes	No	0	8	7
47	R:R:F74	R:R:L78	9.74	Yes	No	0	7	8
48	R:R:F74	R:R:V105	6.55	Yes	No	0	7	6
49	R:R:F74	R:R:L109	13.4	Yes	Yes	1	7	8
50	R:R:F292	R:R:F74	15	Yes	Yes	1	7	7
51	R:R:F74	R:R:S295	6.61	Yes	No	0	7	9
52	R:R:I101	R:R:T77	6.08	Yes	No	0	5	7
53	R:R:T77	R:R:V104	4.76	No	No	0	7	5
54	R:R:F80	R:R:F93	11.79	No	Yes	0	6	7
55	R:R:F80	R:R:I101	15.07	No	Yes	0	6	5
56	R:R:H102	R:R:L81	6.43	Yes	No	0	6	6
57	R:R:S84	R:R:W91	4.94	No	Yes	0	5	9
58	R:R:E89	R:R:M85	8.12	Yes	Yes	2	4	6
59	R:R:M85	R:R:N285	4.21	Yes	No	2	6	4
60	R:R:M87	R:R:P92	5.03	No	No	0	4	3
61	R:R:E89	R:R:N285	3.94	Yes	No	2	4	4
62	R:R:D173	R:R:K90	19.36	Yes	No	2	3	4
63	R:R:K90	R:R:Y175	9.55	No	Yes	2	4	3
64	R:R:F93	R:R:W91	13.03	Yes	Yes	0	7	9
65	R:R:C98	R:R:W91	9.14	No	Yes	1	9	9
66	R:R:I101	R:R:W91	8.22	Yes	Yes	0	5	9
67	R:R:H102	R:R:W91	7.41	Yes	Yes	1	6	9
68	R:R:C176	R:R:W91	5.22	Yes	Yes	1	9	9
69	R:R:F93	R:R:P92	8.67	Yes	No	0	7	3
70	R:R:F93	R:R:L97	6.09	Yes	No	0	7	7
71	R:R:C98	R:R:W95	3.92	No	Yes	0	9	4
72	R:R:K99	R:R:W95	8.12	No	Yes	0	7	4
73	R:R:T165	R:R:W95	4.85	No	Yes	0	4	4
74	R:R:T166	R:R:W95	3.64	No	Yes	0	5	4
75	R:R:F96	R:R:L100	4.87	No	No	0	1	5
76	R:R:I101	R:R:L97	7.14	Yes	No	0	5	7
77	R:R:C176	R:R:C98	5.46	Yes	No	1	9	9
78	R:R:H102	R:R:L164	3.86	Yes	Yes	1	6	5
79	R:R:C176	R:R:H102	7.37	Yes	Yes	1	9	6
80	R:R:F161	R:R:I103	12.56	No	No	0	4	5
81	R:R:N108	R:R:V104	4.43	Yes	No	0	8	5
82	R:R:D106	R:R:T157	4.34	No	No	0	5	7
83	R:R:D106	R:R:V160	4.38	No	No	0	5	4
84	L:L:?1	R:R:D106	17.61	Yes	No	0	0	5
85	R:R:I107	R:R:N108	4.25	Yes	Yes	0	5	8
86	R:R:I107	R:R:T157	10.64	Yes	No	0	5	7
87	R:R:N108	R:R:W150	4.52	Yes	No	0	8	9
88	R:R:L109	R:R:W254	5.69	Yes	Yes	1	8	9
89	R:R:F292	R:R:L109	4.87	Yes	Yes	1	7	8
90	L:L:?1	R:R:L109	8.45	Yes	Yes	1	0	8
91	R:R:F110	R:R:F114	7.5	Yes	Yes	0	7	6
92	R:R:F110	R:R:L156	12.18	Yes	No	0	7	5
93	L:L:?1	R:R:F110	16.73	Yes	Yes	0	0	7
94	R:R:F114	R:R:V113	5.24	Yes	Yes	0	6	7
95	R:R:P213	R:R:V113	5.3	No	Yes	0	9	7
96	R:R:F250	R:R:V113	3.93	Yes	Yes	1	9	7
97	R:R:V113	R:R:W254	6.13	Yes	Yes	1	7	9
98	R:R:F114	R:R:L152	9.74	Yes	No	0	6	4
99	R:R:F114	R:R:I208	5.02	Yes	No	0	6	5
100	R:R:F250	R:R:I116	5.02	Yes	Yes	1	9	8
101	R:R:I116	R:R:N298	8.5	Yes	Yes	1	8	9
102	R:R:I116	R:R:Y302	9.67	Yes	Yes	1	8	9
103	R:R:F118	R:R:V145	5.24	No	No	0	7	5
104	R:R:F118	R:R:I146	5.02	No	Yes	0	7	7
105	R:R:I119	R:R:R123	6.26	Yes	Yes	1	9	9
106	R:R:I119	R:R:Y302	4.84	Yes	Yes	1	9	9
107	R:R:A120	R:R:Y221	5.34	No	Yes	0	9	8
108	R:R:I216	R:R:L121	4.28	No	No	0	6	7
109	R:R:C126	R:R:D122	4.67	No	No	3	8	8
110	R:R:D122	R:R:R137	13.1	No	Yes	3	8	7
111	R:R:R123	R:R:Y221	9.26	Yes	Yes	1	9	8
112	R:R:R123	R:R:Y302	8.23	Yes	Yes	1	9	9
113	R:R:C124	R:R:L128	4.76	No	No	0	8	7
114	R:R:C124	R:R:C220	7.28	No	No	0	8	7
115	R:R:C126	R:R:R137	6.96	No	Yes	3	8	7
116	R:R:I224	R:R:V127	9.22	No	No	0	8	8
117	R:R:K227	R:R:V127	4.55	No	No	0	5	8
118	R:R:H129	R:R:L128	3.86	No	No	0	6	7
119	R:R:L128	R:R:L223	5.54	No	No	0	7	3
120	R:R:H136	R:R:W132	17.98	No	No	0	3	5
121	R:R:H136	R:R:N135	6.38	No	No	0	3	4
122	R:R:G148	R:R:P149	4.06	No	No	0	3	7
123	R:R:I204	R:R:L156	5.71	No	No	0	4	5
124	R:R:I208	R:R:L156	4.28	No	No	0	5	5
125	R:R:F161	R:R:L158	7.31	No	No	0	4	4
126	R:R:L164	R:R:V160	7.45	Yes	No	1	5	4
127	R:R:F178	R:R:V160	3.93	Yes	No	1	4	4
128	R:R:F163	R:R:L162	4.87	Yes	No	1	5	5
129	R:R:L162	R:R:W183	4.56	No	No	1	5	4
130	R:R:F163	R:R:F180	10.72	Yes	Yes	1	5	6
131	R:R:F163	R:R:W183	23.05	Yes	No	1	5	4
132	R:R:F163	R:R:M197	6.22	Yes	No	0	5	1
133	R:R:C176	R:R:L164	4.76	Yes	Yes	1	9	5
134	R:R:F178	R:R:L164	9.74	Yes	Yes	1	4	5
135	R:R:T166	R:R:T174	4.71	No	No	0	5	5
136	R:R:N179	R:R:V167	5.91	No	No	0	3	1
137	R:R:T168	R:R:T174	4.71	No	No	0	2	5
138	R:R:I169	R:R:P170	6.77	No	No	0	1	3
139	R:R:D173	R:R:N171	4.04	Yes	No	0	3	4
140	R:R:D173	R:R:Y175	8.05	Yes	Yes	2	3	3
141	R:R:F178	R:R:F180	4.29	Yes	Yes	1	4	6
142	R:R:F178	R:R:L198	3.65	Yes	No	1	4	4
143	R:R:F178	R:R:R201	14.97	Yes	No	1	4	5
144	R:R:A181	R:R:N179	4.69	No	No	0	5	3
145	R:R:A194	R:R:F180	8.32	No	Yes	0	3	6
146	R:R:F180	R:R:L198	6.09	Yes	No	1	6	4
147	R:R:E189	R:R:T186	19.76	No	No	0	3	6
148	R:R:E188	R:R:P187	4.72	No	No	0	3	5
149	R:R:P187	R:R:R190	12.97	No	No	0	5	5
150	R:R:F273	R:R:L191	7.31	Yes	No	0	5	1
151	R:R:I195	R:R:L268	4.28	No	No	0	1	3
152	R:R:L198	R:R:L268	4.15	No	No	0	4	3
153	R:R:R201	R:R:R205	11.73	No	Yes	1	5	5
154	L:L:?1	R:R:R201	9.27	Yes	No	1	0	5
155	R:R:G202	R:R:R205	4.5	No	Yes	0	4	5
156	R:R:G202	R:R:T265	5.46	No	No	0	4	4
157	R:R:Q258	R:R:R205	7.01	Yes	Yes	1	8	5
158	L:L:?1	R:R:R205	17.62	Yes	Yes	1	0	5
159	R:R:F206	R:R:S211	5.28	No	No	0	6	4
160	R:R:F206	R:R:Q258	4.68	No	Yes	0	6	8
161	R:R:F206	R:R:L262	10.96	No	No	0	6	5
162	R:R:F210	R:R:M214	14.93	Yes	Yes	1	9	6
163	R:R:F210	R:R:F251	5.36	Yes	Yes	1	9	6
164	R:R:F210	R:R:F255	9.65	Yes	No	1	9	6
165	R:R:F210	R:R:Q258	9.37	Yes	Yes	1	9	8
166	R:R:L212	R:R:P213	4.93	No	No	0	5	9
167	R:R:I216	R:R:L212	4.28	No	No	0	6	5
168	R:R:F250	R:R:M214	7.46	Yes	Yes	1	9	6
169	R:R:F251	R:R:M214	8.71	Yes	Yes	1	6	6
170	R:R:V217	R:R:Y221	5.05	No	Yes	0	8	8
171	R:R:I224	R:R:Y221	3.63	No	Yes	0	8	8
172	R:R:L243	R:R:Y221	7.03	No	Yes	0	8	8
173	R:R:V246	R:R:Y221	8.83	No	Yes	0	8	8
174	R:R:V247	R:R:Y221	3.79	No	Yes	0	8	8
175	R:R:Y221	R:R:Y302	5.96	Yes	Yes	1	8	9
176	R:R:K227	R:R:K231	4.31	No	No	0	5	5
177	R:R:I228	R:R:I234	7.36	No	No	0	8	4
178	R:R:K231	R:R:M233	7.2	No	No	0	5	3
179	R:R:R238	R:R:R241	5.33	Yes	No	0	7	5
180	R:R:R238	R:R:R310	4.26	Yes	No	0	7	8
181	R:R:R241	R:R:V242	5.23	No	No	0	5	8
182	R:R:L297	R:R:S249	6.01	No	No	0	6	7
183	R:R:F250	R:R:W254	7.02	Yes	Yes	1	9	9
184	R:R:F251	R:R:F255	16.08	Yes	No	1	6	6
185	R:R:C253	R:R:N294	9.45	No	No	0	8	9
186	R:R:F257	R:R:W254	4.01	Yes	Yes	1	7	9
187	R:R:Q258	R:R:W254	6.57	Yes	Yes	1	8	9
188	R:R:A291	R:R:W254	6.48	No	Yes	1	8	9
189	R:R:N294	R:R:W254	7.91	No	Yes	0	9	9
190	L:L:?1	R:R:W254	6.09	Yes	Yes	1	0	9
191	R:R:F255	R:R:L259	8.53	No	No	0	6	5
192	R:R:L290	R:R:P256	4.93	No	No	0	8	9
193	R:R:F257	R:R:Q258	4.68	Yes	Yes	1	7	8
194	R:R:F257	R:R:T287	3.89	Yes	No	0	7	7
195	R:R:A291	R:R:F257	4.16	No	Yes	1	8	7
196	L:L:?1	R:R:F257	7.44	Yes	Yes	1	0	7
197	R:R:L259	R:R:L263	4.15	No	No	0	5	5
198	R:R:T287	R:R:V260	7.93	No	No	0	7	5
199	R:R:L263	R:R:W267	4.56	No	Yes	0	5	3
200	R:R:V266	R:R:W267	4.9	No	Yes	0	4	3
201	R:R:W267	R:R:Y277	15.43	Yes	No	0	3	3
202	R:R:E270	R:R:K269	13.5	No	No	0	2	4
203	R:R:F273	R:R:K269	3.72	Yes	No	0	5	4
204	R:R:I280	R:R:M271	4.37	No	No	0	4	1
205	R:R:K276	R:R:Y277	15.53	No	No	0	1	3
206	L:L:?1	R:R:V284	10.23	Yes	No	0	0	5
207	R:R:F292	R:R:S288	6.61	Yes	No	0	7	6
208	R:R:C296	R:R:F293	8.38	No	No	0	8	5
209	R:R:F293	R:R:L297	6.09	No	No	0	5	6
210	R:R:N294	R:R:N298	5.45	No	Yes	0	9	9
211	R:R:L297	R:R:L301	4.15	No	No	0	6	8
212	R:R:F304	R:R:M300	3.73	No	No	0	7	7
213	R:R:F309	R:R:V303	9.18	Yes	No	1	8	7
214	R:R:F304	R:R:F309	6.43	No	Yes	0	7	8
215	R:R:Q307	R:R:R310	10.51	No	No	0	5	8
216	R:R:E311	R:R:H315	6.15	No	No	0	4	4
217	R:R:A133	R:R:C126	3.61	No	No	0	5	8
218	R:R:P29	R:R:S289	3.56	No	No	0	5	5
219	R:R:P187	R:R:T186	3.5	No	No	0	5	6
220	R:R:P256	R:R:T287	3.5	No	No	0	9	7
221	R:R:A68	R:R:V47	3.39	No	No	0	8	9
222	R:R:C63	R:R:I119	3.27	No	Yes	0	7	9
223	R:R:C63	R:R:I146	3.27	No	Yes	0	7	7
224	R:R:C124	R:R:I224	3.27	No	No	0	8	8
225	R:R:E270	R:R:W267	3.27	No	Yes	0	2	3
226	R:R:S289	R:R:V32	3.23	No	No	0	5	5
227	R:R:R312	R:R:R54	3.2	No	No	0	5	4
228	R:R:S140	R:R:T138	3.2	No	No	0	4	6
229	R:R:T75	R:R:V41	3.17	No	No	0	7	6
230	R:R:T177	R:R:V167	3.17	No	No	0	3	1
231	R:R:A86	R:R:L30	3.15	No	No	0	4	5
232	R:R:A225	R:R:L243	3.15	No	No	0	5	8
233	R:R:A70	R:R:N108	3.13	No	Yes	0	8	8
234	R:R:F273	R:R:Y274	3.09	Yes	No	0	5	5
235	R:R:K144	R:R:S140	3.06	No	No	0	1	4
236	R:R:I203	R:R:T199	3.04	No	No	0	4	3
237	R:R:F72	R:R:G45	3.01	No	No	0	7	4
238	R:R:F53	R:R:G52	3.01	No	No	0	4	4
239	R:R:F110	R:R:G209	3.01	Yes	No	0	7	6
240	R:R:L67	R:R:S112	3	Yes	No	0	9	9
241	R:R:G184	R:R:R190	3	No	No	0	3	5
242	R:R:G185	R:R:R190	3	No	No	0	3	5
243	R:R:L313	R:R:V50	2.98	No	No	0	6	7
244	R:R:L301	R:R:V246	2.98	No	No	0	8	8
245	R:R:L283	R:R:V260	2.98	No	No	0	6	5
246	R:R:I103	R:R:I107	2.94	No	Yes	0	5	5
247	R:R:I228	R:R:M233	2.92	No	No	0	8	3
248	R:R:F114	R:R:P149	2.89	Yes	No	0	6	7
249	R:R:F118	R:R:P149	2.89	No	No	0	7	7
250	R:R:P239	R:R:R238	2.88	No	Yes	0	7	7
251	R:R:I82	R:R:L30	2.85	No	No	0	7	5
252	R:R:I82	R:R:L33	2.85	No	Yes	0	7	7
253	R:R:I48	R:R:L69	2.85	No	No	0	7	6
254	R:R:I107	R:R:L154	2.85	Yes	No	0	5	4
255	R:R:I219	R:R:L223	2.85	No	No	0	3	3
256	R:R:I234	R:R:L240	2.85	No	No	0	4	5
257	R:R:I280	R:R:L263	2.85	No	No	0	4	5
258	R:R:L30	R:R:M85	2.83	No	Yes	0	5	6
259	R:R:L33	R:R:M85	2.83	Yes	Yes	0	7	6
260	R:R:A51	R:R:F309	2.77	No	Yes	0	7	8
261	R:R:A261	R:R:R205	2.77	No	Yes	0	5	5
262	R:R:A261	R:R:F257	2.77	No	Yes	0	5	7
263	R:R:N135	R:R:Q134	2.64	No	No	0	4	5
264	R:R:F93	R:R:V83	2.62	Yes	No	0	7	5
265	R:R:F180	R:R:V193	2.62	Yes	No	0	6	4
266	R:R:D308	R:R:E311	2.6	No	No	0	6	4
267	R:R:I62	R:R:R57	2.51	No	No	0	7	6
268	R:R:F304	R:R:L46	2.44	No	No	0	7	6
269	R:R:F96	R:R:L97	2.44	No	No	0	1	7
270	R:R:F273	R:R:L272	2.44	Yes	No	0	5	3
271	R:R:I279	R:R:Y22	2.42	No	No	0	3	2
272	R:R:I169	R:R:Y175	2.42	No	Yes	0	1	3
273	R:R:I125	R:R:W132	2.35	No	No	0	5	5
274	R:R:L25	R:R:Y22	2.34	No	No	0	3	2
275	R:R:E89	R:R:Y175	2.24	Yes	Yes	2	4	3
276	R:R:A20	R:R:G21	1.95	No	No	0	4	4
277	R:R:A153	R:R:G111	1.95	No	No	0	8	7
278	R:R:A120	R:R:G117	1.95	No	No	0	9	7
279	R:R:A225	R:R:G222	1.95	No	No	0	5	3
280	R:R:G184	R:R:V193	1.84	No	No	0	3	4
281	R:R:G306	R:R:V305	1.84	No	No	0	8	7
282	R:R:P239	R:R:S236	1.78	No	No	0	7	6
283	R:R:G34	R:R:I82	1.76	No	No	0	5	7
284	R:R:G264	R:R:I280	1.76	No	No	0	4	4
285	R:R:G275	R:R:K278	1.74	No	No	0	1	1
286	R:R:G43	R:R:L42	1.71	No	No	0	8	4
287	R:R:I228	R:R:P239	1.69	No	No	0	8	7
288	R:R:D173	R:R:G172	1.68	Yes	No	0	3	4
289	R:R:L25	R:R:P286	1.64	No	No	0	3	6
290	R:R:E89	R:R:G88	1.64	Yes	No	0	4	3
291	R:R:L158	R:R:P159	1.64	No	No	0	4	8
292	R:R:A153	R:R:I107	1.62	No	Yes	0	8	5
293	R:R:A133	R:R:I125	1.62	No	No	0	5	5
294	R:R:A248	R:R:I252	1.62	No	No	0	4	6
295	R:R:A218	R:R:M214	1.61	No	Yes	0	5	6
296	R:R:T165	R:R:V167	1.59	No	No	0	4	1
297	R:R:A245	R:R:L301	1.58	No	No	0	6	8
298	R:R:T199	R:R:T265	1.57	No	No	0	3	4
299	R:R:I216	R:R:S215	1.55	No	No	0	6	3
300	R:R:I27	R:R:V31	1.54	No	No	0	6	6
301	R:R:I146	R:R:V147	1.54	Yes	No	0	7	4
302	R:R:I151	R:R:V155	1.54	No	No	0	3	4
303	R:R:I203	R:R:V207	1.54	No	No	0	4	4
304	R:R:I208	R:R:V207	1.54	No	No	0	5	4
305	R:R:H129	R:R:P130	1.53	No	No	0	6	8
306	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
307	R:R:G88	R:R:R26	1.5	No	No	0	3	4
308	R:R:G306	R:R:R238	1.5	No	Yes	0	8	7
309	R:R:L25	R:R:V24	1.49	No	No	0	3	4
310	R:R:L28	R:R:V24	1.49	No	No	0	5	4
311	R:R:L39	R:R:V35	1.49	No	No	0	5	5
312	R:R:L141	R:R:V145	1.49	No	No	0	3	5
313	R:R:N135	R:R:V131	1.48	No	No	0	4	5
314	R:R:L141	R:R:T138	1.47	No	No	0	3	6
315	R:R:I279	R:R:I282	1.47	No	No	0	3	2
316	R:R:D308	R:R:M55	1.39	No	No	0	6	5
317	R:R:H229	R:R:I234	1.33	No	No	0	3	4
318	R:R:F251	R:R:I252	1.26	Yes	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L33	4.3725	4	0	7
2	R:R:F37	4.3225	4	0	6
3	R:R:Y64	5.5375	4	1	8
4	R:R:L67	4.79	5	1	9
5	R:R:F74	10.26	5	1	7
6	R:R:M85	4.4975	4	2	6
7	R:R:E89	3.985	4	2	4
8	R:R:W91	7.99333	6	1	9
9	R:R:F93	7.285	6	0	7
10	R:R:W95	5.1325	4	0	4
11	R:R:I101	9.1275	4	0	5
12	R:R:H102	6.2675	4	1	6
13	R:R:I107	4.46	5	0	5
14	R:R:N108	5.352	5	0	8
15	R:R:L109	8.1025	4	1	8
16	R:R:F110	9.855	4	0	7
17	R:R:V113	5.15	4	1	7
18	R:R:F114	6.078	5	0	6
19	R:R:I116	6.8675	4	1	8
20	R:R:I119	4.456	5	1	9
21	R:R:R123	7.7375	4	1	9
22	R:R:R137	11.21	4	3	7
23	R:R:I146	5.29	4	0	7
24	R:R:F163	11.215	4	1	5
25	R:R:L164	6.4525	4	1	5
26	R:R:D173	8.2825	4	2	3
27	R:R:Y175	5.565	4	2	3
28	R:R:C176	5.7025	4	1	9
29	R:R:F178	7.316	5	1	4
30	R:R:F180	6.408	5	1	6
31	R:R:R205	8.726	5	1	5
32	R:R:F210	9.8275	4	1	9
33	R:R:M214	8.1775	4	1	6
34	R:R:Y221	6.11125	8	1	8
35	R:R:R238	3.4925	4	0	7
36	R:R:F250	5.8575	4	1	9
37	R:R:F251	7.8525	4	1	6
38	R:R:W254	6.2375	8	1	9
39	R:R:F257	4.49167	6	1	7
40	R:R:Q258	6.462	5	1	8
41	R:R:W267	7.04	4	0	3
42	R:R:F273	4.14	4	0	5
43	R:R:F292	8.4475	4	1	7
44	R:R:N298	7.23	4	1	9
45	R:R:Y302	7.175	4	1	9
46	R:R:F309	6.72167	6	1	8
47	L:L:?1	11.68	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P29	R:R:S289	12.5062	3.56	No	No	0	5	5
2	R:R:L33	R:R:S289	15.5964	4.5	Yes	No	0	7	5
3	R:R:F292	R:R:L33	43.3052	7.31	Yes	Yes	0	7	7
4	R:R:L301	R:R:V246	11.2457	2.98	No	No	0	8	8
5	R:R:V246	R:R:Y221	12.4235	8.83	No	Yes	0	8	8
6	R:R:Y221	R:R:Y302	38.6931	5.96	Yes	Yes	1	8	9
7	R:R:I116	R:R:Y302	76.3871	9.67	Yes	Yes	1	8	9
8	R:R:F250	R:R:I116	100	5.02	Yes	Yes	1	9	8
9	R:R:F250	R:R:W254	69.7204	7.02	Yes	Yes	1	9	9
10	R:R:L109	R:R:W254	37.7833	5.69	Yes	Yes	1	8	9
11	R:R:F292	R:R:L109	45.0918	4.87	Yes	Yes	1	7	8
12	R:R:F74	R:R:L78	11.067	9.74	Yes	No	0	7	8
13	R:R:D71	R:R:N44	19.1034	13.46	No	No	0	9	9
14	R:R:D71	R:R:N298	20.3242	6.73	No	Yes	0	9	9
15	R:R:N294	R:R:N298	29.3036	5.45	No	Yes	0	9	9
16	R:R:N294	R:R:W254	30.2101	7.91	No	Yes	0	9	9
17	R:R:F72	R:R:N44	14.1538	6.04	No	No	0	7	9
18	R:R:I116	R:R:L67	24.0827	4.28	Yes	Yes	1	8	9
19	R:R:I119	R:R:L67	40.4334	4.28	Yes	Yes	1	9	9
20	R:R:I119	R:R:Y64	64.2581	3.63	Yes	Yes	1	9	8
21	R:R:V303	R:R:Y64	48.268	7.57	No	Yes	1	7	8
22	R:R:L67	R:R:N298	19.1563	8.24	Yes	Yes	1	9	9
23	R:R:I119	R:R:Y302	26.6005	4.84	Yes	Yes	1	9	9
24	R:R:R123	R:R:Y302	20.7179	8.23	Yes	Yes	1	9	9
25	R:R:R123	R:R:Y64	24.9198	7.2	Yes	Yes	1	9	8
26	R:R:F309	R:R:V303	40.2283	9.18	Yes	No	1	8	7
27	R:R:F72	R:R:I48	11.6394	3.77	No	No	0	7	7
28	R:R:F309	R:R:M55	19.1266	6.22	Yes	No	0	8	5
29	R:R:T60	R:R:Y64	40.311	3.75	No	Yes	0	7	8
30	R:R:R137	R:R:T60	32.3077	5.17	Yes	No	0	7	7
31	R:R:F114	R:R:P149	10.7395	2.89	Yes	No	0	6	7
32	L:L:?1	R:R:F110	14.1969	16.73	Yes	Yes	0	0	7
33	L:L:?1	R:R:L109	23.3251	8.45	Yes	Yes	1	0	8
34	R:R:F114	R:R:V113	13.5715	5.24	Yes	Yes	0	6	7
35	R:R:I146	R:R:N66	14.9082	11.33	Yes	No	0	7	9
36	L:L:?1	R:R:D106	39.8379	17.61	Yes	No	0	0	5
37	R:R:D106	R:R:T157	12.4202	4.34	No	No	0	5	7
38	R:R:I107	R:R:T157	11.2291	10.64	Yes	No	0	5	7
39	R:R:N108	R:R:W150	14.0017	4.52	Yes	No	0	8	9
40	R:R:N66	R:R:W150	13.9355	5.65	No	No	0	9	9
41	R:R:I101	R:R:W91	12.1654	8.22	Yes	Yes	0	5	9
42	R:R:H102	R:R:W91	15.4376	7.41	Yes	Yes	1	6	9
43	R:R:H102	R:R:L164	19.3449	3.86	Yes	Yes	1	6	5
44	R:R:L164	R:R:V160	27.3714	7.45	Yes	No	1	5	4
45	R:R:D106	R:R:V160	29.3532	4.38	No	No	0	5	4
46	R:R:C176	R:R:W91	15.2721	5.22	Yes	Yes	1	9	9
47	R:R:C176	R:R:L164	40.7146	4.76	Yes	Yes	1	9	5
48	R:R:F178	R:R:L164	34.7163	9.74	Yes	Yes	1	4	5
49	R:R:F178	R:R:R201	50.9711	14.97	Yes	No	1	4	5
50	L:L:?1	R:R:R201	44.7279	9.27	Yes	No	1	0	5
51	R:R:N108	R:R:V104	10.2862	4.43	Yes	No	0	8	5
52	R:R:F93	R:R:W91	19.1464	13.03	Yes	Yes	0	7	9
53	R:R:E89	R:R:M85	15.4508	8.12	Yes	Yes	2	4	6
54	R:R:L33	R:R:M85	21.3565	2.83	Yes	Yes	0	7	6
55	R:R:E89	R:R:Y175	10.9446	2.24	Yes	Yes	2	4	3
56	R:R:C176	R:R:C98	23.507	5.46	Yes	No	1	9	9
57	R:R:C98	R:R:W95	23.9504	3.92	No	Yes	0	9	4
58	R:R:T165	R:R:W95	12.0562	4.85	No	Yes	0	4	4
59	R:R:C126	R:R:R137	21.8065	6.96	No	Yes	3	8	7
60	R:R:I224	R:R:Y221	29.7237	3.63	No	Yes	0	8	8
61	R:R:I224	R:R:V127	20.5624	9.22	No	No	0	8	8
62	R:R:K227	R:R:V127	19.4806	4.55	No	No	0	5	8
63	R:R:H136	R:R:W132	10.9942	17.98	No	No	0	3	5
64	R:R:I125	R:R:W132	13.727	2.35	No	No	0	5	5
65	R:R:A133	R:R:I125	16.4533	1.62	No	No	0	5	5
66	R:R:A133	R:R:C126	19.1729	3.61	No	No	0	5	8
67	R:R:F178	R:R:F180	18.0976	4.29	Yes	Yes	1	4	6
68	R:R:F180	R:R:V193	10.6435	2.62	Yes	No	0	6	4
69	R:R:E270	R:R:K269	10.7163	13.5	No	No	0	2	4
70	R:R:E270	R:R:W267	12.8768	3.27	No	Yes	0	2	3
71	R:R:L263	R:R:W267	21.4524	4.56	No	Yes	0	5	3
72	R:R:L259	R:R:L263	29.5715	4.15	No	No	0	5	5
73	R:R:F255	R:R:L259	31.6725	8.53	No	No	0	6	5
74	R:R:F210	R:R:F255	23.0835	9.65	Yes	No	1	9	6
75	R:R:F210	R:R:Q258	15.8478	9.37	Yes	Yes	1	9	8
76	R:R:Q258	R:R:W254	13.5318	6.57	Yes	Yes	1	8	9
77	R:R:F250	R:R:M214	26.9049	7.46	Yes	Yes	1	9	6
78	R:R:F251	R:R:M214	13.3102	8.71	Yes	Yes	1	6	6
79	R:R:K227	R:R:K231	18.3027	4.31	No	No	0	5	5
80	R:R:I228	R:R:M233	15.9206	2.92	No	No	0	8	3
81	R:R:K231	R:R:M233	17.115	7.2	No	No	0	5	3
82	R:R:I228	R:R:P239	11.0703	1.69	No	No	0	8	7
83	R:R:C63	R:R:I119	20.708	3.27	No	Yes	0	7	9
84	R:R:F74	R:R:L109	14.6865	13.4	Yes	Yes	1	7	8
85	R:R:C63	R:R:I146	19.4409	3.27	No	Yes	0	7	7
86	L:L:?1	R:R:W254	60.9462	6.09	Yes	Yes	1	0	9
87	R:R:F250	R:R:V113	12.9992	3.93	Yes	Yes	1	9	7
88	R:R:F210	R:R:M214	11.732	14.93	Yes	Yes	1	9	6
89	R:R:F251	R:R:F255	10.6799	16.08	Yes	No	1	6	6
90	R:R:Q258	R:R:R205	11.1563	7.01	Yes	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F74	R:R:L109	13.4	1	Yes	Yes	7	8	2	1
R:R:F292	R:R:F74	15	1	Yes	Yes	7	7	2	2
R:R:D106	R:R:T157	4.34	0	No	No	5	7	1	2
R:R:D106	R:R:V160	4.38	0	No	No	5	4	1	2
L:L:?1	R:R:D106	17.61	1	Yes	No	0	5	0	1
R:R:L109	R:R:W254	5.69	1	Yes	Yes	8	9	1	1
R:R:F292	R:R:L109	4.87	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:L109	8.45	1	Yes	Yes	0	8	0	1
R:R:F110	R:R:F114	7.5	0	Yes	Yes	7	6	1	2
R:R:F110	R:R:L156	12.18	0	Yes	No	7	5	1	2
L:L:?1	R:R:F110	16.73	1	Yes	Yes	0	7	0	1
R:R:F114	R:R:V113	5.24	0	Yes	Yes	6	7	2	2
R:R:F250	R:R:V113	3.93	1	Yes	Yes	9	7	2	2
R:R:V113	R:R:W254	6.13	1	Yes	Yes	7	9	2	1
R:R:F178	R:R:V160	3.93	1	Yes	No	4	4	2	2
R:R:F178	R:R:R201	14.97	1	Yes	No	4	5	2	1
R:R:R201	R:R:R205	11.73	1	No	Yes	5	5	1	1
L:L:?1	R:R:R201	9.27	1	Yes	No	0	5	0	1
R:R:G202	R:R:R205	4.5	0	No	Yes	4	5	2	1
R:R:Q258	R:R:R205	7.01	1	Yes	Yes	8	5	2	1
L:L:?1	R:R:R205	17.62	1	Yes	Yes	0	5	0	1
R:R:F250	R:R:W254	7.02	1	Yes	Yes	9	9	2	1
R:R:F257	R:R:W254	4.01	1	Yes	Yes	7	9	1	1
R:R:Q258	R:R:W254	6.57	1	Yes	Yes	8	9	2	1
R:R:A291	R:R:W254	6.48	1	No	Yes	8	9	2	1
R:R:N294	R:R:W254	7.91	0	No	Yes	9	9	2	1
L:L:?1	R:R:W254	6.09	1	Yes	Yes	0	9	0	1
R:R:F257	R:R:Q258	4.68	1	Yes	Yes	7	8	1	2
R:R:F257	R:R:T287	3.89	1	Yes	No	7	7	1	2
R:R:A291	R:R:F257	4.16	1	No	Yes	8	7	2	1
L:L:?1	R:R:F257	7.44	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V284	10.23	1	Yes	No	0	5	0	1
R:R:F110	R:R:G209	3.01	0	Yes	No	7	6	1	2
R:R:A261	R:R:R205	2.77	0	No	Yes	5	5	2	1
R:R:A261	R:R:F257	2.77	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T6S_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	283
Number of Links	318
Number of Hubs	47
Number of Links mediated by Hubs	166
Number of Communities	3
Number of Nodes involved in Communities	49
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	75884
Length Of Smallest Path	3
Average Path Length	12.8388
Length of Longest Path	26
Minimum Path Strength	1.44
Average Path Strength	6.5088
Maximum Path Strength	17.615
Minimum Path Correlation	0.7
Average Path Correlation	0.928214
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	51.8711
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.3015
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • molecular transducer activity • signaling receptor activity • amide binding • amyloid-beta binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • RAGE receptor binding • signaling receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • negative regulation of biological process • response to external stimulus • regulation of inflammatory response • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • locomotion • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of transport • regulation of phagocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • negative regulation of apoptotic process • negative regulation of cellular process • regulation of neuron apoptotic process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell migration • cell motility • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • cell adhesion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • defense response to other organism • positive regulation of defense response • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • tertiary granule membrane • intracellular vesicle • tertiary granule • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule membrane • specific granule • ficolin-1-rich granule membrane • ficolin-1-rich granule • G-protein beta-subunit binding • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FUI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FUI
Name	N-(4-chlorophenyl)-N'-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea
Synonyms
Identifier
Formula	C20 H21 Cl N4 O2
Molecular Weight	384.859
SMILES
PubChem	24776341
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	0
Total Bonds	50
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>7T6S_nogp_Chain_R A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188

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