Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I48 3.1375407
2R:R:I62 3.955477
3R:R:Y64 4.07528
4R:R:D71 5.422569
5R:R:F72 3.895407
6R:R:F74 9.4475407
7R:R:W91 9.22639
8R:R:F93 8.27407
9R:R:I101 6.095435
10R:R:V105 5.37416
11R:R:D106 8.2575415
12R:R:F114 5.415406
13R:R:I116 6.155408
14R:R:I119 6.125429
15R:R:R123 6.395429
16R:R:W132 3.8225405
17R:R:R137 8.68447
18R:R:F178 6.59167614
19R:R:F180 5.2375406
20R:R:R201 8.7575415
21R:R:R205 7.32333615
22R:R:F210 6.7275489
23R:R:Y221 4.78857728
24R:R:I234 4.87404
25R:R:F250 4.495489
26R:R:W254 6.91409
27R:R:F292 6.87457
28R:R:C296 3.6225408
29R:R:Y302 6.638529
30R:R:F309 8.6325408
31L:L:?1 13.6817610
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:N285 R:R:P29 12.1263.26NoNo045
2R:R:N285 R:R:V284 16.76182.96NoNo045
3L:L:F3 R:R:V284 19.15546.55NoNo005
4L:L:F3 R:R:R205 23.67434.28NoYes005
5L:L:?1 R:R:R205 28.874116.52YesYes105
6L:L:?1 R:R:L109 31.10946.28YesNo008
7R:R:F74 R:R:L109 31.563410.96YesNo078
8R:R:F74 R:R:S295 67.25363.96YesNo079
9R:R:D71 R:R:S295 67.06798.83YesNo099
10R:R:D71 R:R:N44 28.13126.73YesNo699
11R:R:F72 R:R:N44 38.21453.62YesNo079
12R:R:F72 R:R:V41 43.68253.93YesNo076
13R:R:T75 R:R:V41 33.70934.76NoNo076
14R:R:G40 R:R:T75 31.38463.64NoNo087
15R:R:C296 R:R:G40 29.0463.92YesNo088
16R:R:C296 R:R:F293 19.63684.19YesNo085
17R:R:F292 R:R:F74 25.641415YesYes077
18R:R:F292 R:R:L33 18.75644.87YesNo577
19R:R:I82 R:R:L33 16.50734.28NoNo077
20R:R:F37 R:R:P79 27.684210.11NoNo068
21R:R:F80 R:R:P79 28.00064.33NoNo068
22R:R:F80 R:R:I101 22.58068.79NoYes065
23R:R:I101 R:R:T77 38.8614.56YesNo057
24R:R:T77 R:R:V105 48.10514.76NoYes076
25R:R:D106 R:R:V105 34.10144.38YesYes156
26R:R:D106 R:R:R201 19.21734.76YesYes155
27R:R:R201 R:R:R205 45.50528.53YesYes155
28R:R:H102 R:R:I101 12.14663.98NoYes365
29L:L:I4 R:R:H102 30.90315.3NoNo006
30L:L:I4 R:R:F178 31.98987.54NoYes004
31R:R:F178 R:R:R201 83.16949.62YesYes145
32L:L:?1 R:R:D106 17.20218.46YesYes105
33R:R:D71 R:R:P299 39.83083.22YesNo699
34R:R:A68 R:R:V47 15.86773.39NoNo089
35R:R:P299 R:R:V47 50.12723.53NoNo099
36R:R:Q258 R:R:R205 67.37055.84NoYes085
37R:R:F210 R:R:Q258 69.40648.2YesNo098
38R:R:F210 R:R:F250 64.91513.22YesYes899
39R:R:F250 R:R:I116 85.31545.02YesYes098
40R:R:I116 R:R:Y302 1009.67YesYes089
41R:R:I119 R:R:Y302 48.94426.04YesYes299
42R:R:I119 R:R:Y64 27.19583.63YesYes298
43R:R:V303 R:R:Y64 56.26255.05NoYes078
44R:R:R123 R:R:Y302 27.9737.2YesYes299
45R:R:R123 R:R:Y64 34.66545.14YesYes298
46R:R:V303 R:R:V47 62.10888.02NoNo079
47R:R:F72 R:R:I48 21.70715.02YesYes077
48R:R:F309 R:R:V303 49.62519.18YesNo087
49R:R:F309 R:R:V50 25.249311.8YesNo087
50R:R:V50 R:R:W49 12.73133.68NoNo074
51R:R:F309 R:R:M55 19.01784.98YesNo085
52R:R:I62 R:R:R57 47.54113.76YesNo076
53R:R:R57 R:R:T61 50.44362.59NoNo067
54R:R:T58 R:R:T61 53.33243.14NoNo077
55R:R:T58 R:R:T60 56.20744.71NoNo077
56R:R:T60 R:R:Y64 59.06872.5NoYes078
57R:R:A142 R:R:V59 36.10985.09NoNo076
58R:R:A142 R:R:I62 38.75091.62NoYes077
59R:R:C63 R:R:I119 22.6159.82NoYes279
60R:R:F118 R:R:I146 23.45425.02NoNo077
61R:R:C63 R:R:F118 38.18012.79NoNo077
62R:R:I146 R:R:N66 10.55788.5NoNo079
63R:R:I116 R:R:N298 27.0177.08YesNo089
64R:R:T77 R:R:V104 15.79896.35NoNo075
65R:R:N108 R:R:V104 10.58534.43NoNo085
66R:R:F93 R:R:W91 11.857815.03YesYes079
67R:R:H102 R:R:W91 19.03167.41NoYes369
68R:R:F93 R:R:P92 10.578410.11YesNo073
69R:R:D173 R:R:T174 14.99427.23NoNo035
70R:R:T166 R:R:T174 24.92614.71NoNo055
71R:R:C98 R:R:T166 14.93233.38NoNo395
72R:R:C98 R:R:W91 17.3749.14NoYes399
73R:R:C176 R:R:T166 14.93233.38NoNo395
74R:R:C176 R:R:W91 17.37411.75NoYes399
75R:R:D173 R:R:K90 10.00768.3NoNo034
76R:R:K99 R:R:L164 19.74695.64NoNo075
77R:R:F178 R:R:L164 21.90666.09YesNo145
78R:R:K99 R:R:W95 17.32586.96NoNo074
79L:L:?1 R:R:F110 28.846523.19YesNo007
80R:R:F110 R:R:F114 28.13126.43NoYes076
81R:R:F114 R:R:V113 29.28673.93YesNo067
82R:R:P213 R:R:V113 40.34673.53NoNo097
83R:R:F250 R:R:W254 26.32926.01YesYes099
84R:R:F114 R:R:L152 10.00768.53YesNo064
85R:R:Y221 R:R:Y302 21.83093.97YesYes289
86R:R:I216 R:R:L212 33.45484.28NoNo065
87R:R:L212 R:R:P213 35.76594.93NoNo059
88R:R:C220 R:R:L121 28.97043.17NoNo077
89R:R:I216 R:R:L121 31.13018.56NoNo067
90R:R:R137 R:R:V59 27.168313.08YesNo476
91R:R:C124 R:R:C220 26.61817.28NoNo087
92R:R:C124 R:R:L128 24.2526.35NoNo087
93R:R:L128 R:R:V127 14.63652.98NoNo078
94R:R:A133 R:R:W132 18.48131.3NoYes055
95R:R:A133 R:R:R137 21.51452.77NoYes057
96R:R:F118 R:R:V145 12.94452.62NoNo075
97R:R:L141 R:R:V145 10.55782.98NoNo035
98R:R:I146 R:R:V147 10.55781.54NoNo074
99R:R:F163 R:R:F180 14.82915.36NoYes056
100R:R:F178 R:R:F180 38.15267.5YesYes046
101R:R:T165 R:R:W95 12.44242.43NoNo044
102R:R:F178 R:R:L198 14.62274.87YesNo044
103R:R:E189 R:R:V193 17.32582.85NoNo034
104R:R:F180 R:R:V193 19.51993.93YesNo064
105R:R:E189 R:R:G185 14.8914.91NoNo033
106R:R:G184 R:R:G185 12.44242.11NoNo033
107R:R:K276 R:R:Y277 11.67217.17NoNo013
108R:R:W267 R:R:Y277 14.003724.12NoNo033
109R:R:V266 R:R:W267 18.62583.68NoNo043
110R:R:L262 R:R:V266 20.91622.98NoNo054
111R:R:F206 R:R:L262 23.192812.18NoNo065
112R:R:F206 R:R:Q258 27.70484.68NoNo068
113R:R:L198 R:R:L268 12.23614.15NoNo043
114R:R:G202 R:R:R205 12.30486NoYes045
115R:R:V246 R:R:Y302 10.92236.31NoYes289
116R:R:I234 R:R:L240 11.13565.71YesNo045
117R:R:A225 R:R:L240 13.31591.58NoNo055
118R:R:A225 R:R:L243 17.64221.58NoNo058
119R:R:L243 R:R:Y221 19.58874.69NoYes088
120R:R:N294 R:R:W254 12.119110.17NoYes099
121L:L:?1 R:R:F257 30.39415.52YesNo007
122R:R:F257 R:R:T287 28.13815.19NoNo077
123R:R:T287 R:R:V260 21.28767.93NoNo075
124R:R:I280 R:R:V260 11.96093.07NoNo045
125R:R:D308 R:R:M55 12.73132.77NoNo065
126R:R:I82 R:R:L30 11.85781.43NoNo075
127R:R:V242 R:R:V246 10.35831.6NoNo088
128R:R:F37 R:R:V41 27.93183.93NoNo066
129R:R:N44 R:R:P299 11.555111.4NoNo699
130R:R:A68 R:R:I48 14.48523.25NoYes087
131R:R:C63 R:R:Y64 18.02054.03NoYes278
132R:R:D71 R:R:N298 37.55425.39YesNo099
133R:R:F74 R:R:V105 41.76357.87YesYes076
134R:R:F80 R:R:F93 12.98584.29NoYes067
135R:R:I101 R:R:W91 28.15197.05YesYes359
136L:L:?1 R:R:R201 29.706312.12YesYes105
137R:R:V113 R:R:W254 33.88823.68NoYes079
138R:R:N294 R:R:N298 12.669412.26NoNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F74 R:R:V105 7.87 0 Yes Yes 7 6 2 1
R:R:F74 R:R:L109 10.96 0 Yes No 7 8 2 1
R:R:I101 R:R:T77 4.56 3 Yes No 5 7 2 2
R:R:T77 R:R:V105 4.76 0 No Yes 7 6 2 1
R:R:I101 R:R:W91 7.05 3 Yes Yes 5 9 2 2
R:R:H102 R:R:W91 7.41 3 No Yes 6 9 1 2
R:R:H102 R:R:I101 3.98 3 No Yes 6 5 1 2
L:L:I4 R:R:H102 5.3 0 No No 0 6 0 1
R:R:D106 R:R:V105 4.38 1 Yes Yes 5 6 1 1
L:L:L2 R:R:V105 4.47 1 No Yes 0 6 0 1
R:R:D106 R:R:R201 4.76 1 Yes Yes 5 5 1 1
L:L:?1 R:R:D106 18.46 1 Yes Yes 0 5 0 1
L:L:L2 R:R:D106 5.43 1 No Yes 0 5 0 1
L:L:?1 R:R:L109 6.28 1 Yes No 0 8 0 1
R:R:F110 R:R:F114 6.43 0 No Yes 7 6 1 2
L:L:?1 R:R:F110 23.19 1 Yes No 0 7 0 1
R:R:L164 R:R:V160 5.96 1 No No 5 4 2 2
R:R:F178 R:R:V160 3.93 1 Yes No 4 4 1 2
R:R:F178 R:R:L164 6.09 1 Yes No 4 5 1 2
R:R:F178 R:R:F180 7.5 1 Yes Yes 4 6 1 2
R:R:F178 R:R:L198 4.87 1 Yes No 4 4 1 2
R:R:F178 R:R:R201 9.62 1 Yes Yes 4 5 1 1
L:L:I4 R:R:F178 7.54 0 No Yes 0 4 0 1
R:R:R201 R:R:R205 8.53 1 Yes Yes 5 5 1 1
L:L:?1 R:R:R201 12.12 1 Yes Yes 0 5 0 1
R:R:G202 R:R:R205 6 0 No Yes 4 5 2 1
R:R:Q258 R:R:R205 5.84 0 No Yes 8 5 2 1
L:L:?1 R:R:R205 16.52 1 Yes Yes 0 5 0 1
L:L:F3 R:R:R205 4.28 0 No Yes 0 5 0 1
R:R:F257 R:R:T287 5.19 0 No No 7 7 1 2
L:L:?1 R:R:F257 5.52 1 Yes No 0 7 0 1
L:L:F3 R:R:V284 6.55 0 No No 0 5 0 1
R:R:N285 R:R:V284 2.96 0 No No 4 5 2 1
L:L:L2 R:R:L81 2.77 1 No No 0 6 0 1
R:R:A261 R:R:R205 2.77 0 No Yes 5 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7T6V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.17
Number of Linked Nodes 281
Number of Links 306
Number of Hubs 31
Number of Links mediated by Hubs 114
Number of Communities 9
Number of Nodes involved in Communities 41
Number of Links involved in Communities 51
Path Summary
Number Of Nodes in MetaPath 139
Number Of Links MetaPath 138
Number of Shortest Paths 52928
Length Of Smallest Path 3
Average Path Length 13.4333
Length of Longest Path 31
Minimum Path Strength 1.18
Average Path Strength 5.98095
Maximum Path Strength 20.825
Minimum Path Correlation 0.7
Average Path Correlation 0.931826
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 54.3336
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.8888
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeFME
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeFME
NameN-Formylmethionine
Synonyms
  • L-N-Formylmethionine
  • N-formyl-L-methionine
  • Formyl-methionine
  • N-Formylmethionine
  • (2S)-2-(formylamino)-4-(methylthio)butanoic acid
Identifier
FormulaC6 H11 N O3 S
Molecular Weight177.221
SMILES
PubChem439750
Formal Charge0
Total Atoms22
Total Chiral Atoms1
Total Bonds21
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP25090
Sequence
>7T6V_nogp_Chain_R
AGYTVLRIL PLVVLGVTF VLGVLGNGL VIWVAGFRM TRTVTTICY 
LNLALADFS FTATLPFLI VSMAMGEKW PFGWFLCKL IHIVVDINL 
FGSVFLIGF IALDRCICV LHPVWAQNH RTVSLAMKV IVGPWILAL 
VLTLPVFLF LTTVTIPNG DTYCTFNFA SWGGTPEER LKVAITMLT 
ARGIIRFVI GFSLPMSIV AICYGLIAA KIHKKGMIK SSRPLRVLT 
AVVASFFIC WFPFQLVAL LGTVWLKEM LFYGKYKII DILVNPTSS 
LAFFNSCLN PMLYVFVGQ DFRERLIHS L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6OMMAPeptideFormylpeptideFPR2-ALXHomo sapiensWKYMVX-Gi1/β1/γ23.172020-02-26doi.org/10.1038/s41467-020-14728-9
6OMM (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensWKYMVX-3.172020-02-26doi.org/10.1038/s41467-020-14728-9
6LW5APeptideFormylpeptideFPR2-ALXHomo sapiensWKYMVm--2.82020-03-25doi.org/10.1038/s41467-020-15009-1
7T6SAPeptideFormylpeptideFPR2-ALXHomo sapiensTC-FPR 43-Gi1/β1/γ232022-03-30doi.org/10.1038/s41467-022-28586-0
7T6S (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensTC-FPR 43-32022-03-30doi.org/10.1038/s41467-022-28586-0
7T6UAPeptideFormylpeptideFPR2-ALXHomo sapiensCGEN-855A-Gi1/β1/γ22.92022-03-30doi.org/10.1038/s41467-022-28586-0
7T6U (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensCGEN-855A-2.92022-03-30doi.org/10.1038/s41467-022-28586-0
7T6VAPeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-Gi1/β1/γ23.12022-03-30doi.org/10.1038/s41467-022-28586-0
7T6V (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-3.12022-03-30doi.org/10.1038/s41467-022-28586-0
7WVVAPeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-Gi2/β1/γ22.92022-04-13doi.org/10.1038/s41467-022-29361-x
7WVV (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-2.92022-04-13doi.org/10.1038/s41467-022-29361-x
7WVWAPeptideFormylpeptideFPR2-ALXHomo sapiensfMYFINILTL-Gi2/β1/γ23.12022-04-13doi.org/10.1038/s41467-022-29361-x
7WVW (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensfMYFINILTL-3.12022-04-13doi.org/10.1038/s41467-022-29361-x
7WVXAPeptideFormylpeptideFPR2-ALXHomo sapiensHumanin-Gi2/β1/γ22.82022-04-13doi.org/10.1038/s41467-022-29361-x
7WVX (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensHumanin-2.82022-04-13doi.org/10.1038/s41467-022-29361-x
7WVYAPeptideFormylpeptideFPR2-ALXHomo sapiensAmyloid-β42-Gi2/β1/γ232022-04-13doi.org/10.1038/s41467-022-29361-x
7WVY (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensAmyloid-β42-32022-04-13doi.org/10.1038/s41467-022-29361-x
8Y62APeptideFormylpeptideFPR2-ALXHomo sapiensC16:0 Ceramide-Gi1/β1/γ23.22025-02-05doi.org/10.1126/science.ado4188
8Y62 (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensC16:0 Ceramide-3.22025-02-05doi.org/10.1126/science.ado4188
8Y63APeptideFormylpeptideFPR2-ALXHomo sapiensC20:0 Ceramide-Gi1/β1/γ23.22025-02-05doi.org/10.1126/science.ado4188
8Y63 (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensC20:0 Ceramide-3.22025-02-05doi.org/10.1126/science.ado4188
9JHJAPeptideFormylpeptideFPR2-ALXHomo sapiensC18:0 Ceramide-Gi1/β1/γ23.22025-03-19doi.org/10.1126/science.ado4188
9JHJ (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensC18:0 Ceramide-3.22025-03-19doi.org/10.1126/science.ado4188
8ZBWAPeptideFormylpeptideFPR2-ALXHomo sapiensQuin-C1-Gi2/β1/γ22.582025-09-10doi.org/10.1038/s41401-025-01525-7
8ZBW (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensQuin-C1-2.582025-09-10doi.org/10.1038/s41401-025-01525-7




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