psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E89	8.68	Yes	No	0	0	4
2	L:L:?1	R:R:D106	4.04	Yes	No	3	0	5
3	L:L:?1	R:R:F110	2.9	Yes	No	3	0	7
4	L:L:?1	R:R:P170	2.94	Yes	No	0	0	3
5	L:L:?1	R:R:Y175	14.67	Yes	Yes	3	0	3
6	L:L:?1	R:R:T177	7.03	Yes	No	3	0	3
7	L:L:?1	R:R:N179	8.18	Yes	No	0	0	3
8	L:L:?1	R:R:R201	5.79	Yes	No	0	0	5
9	L:L:?1	R:R:R205	9.41	Yes	No	0	0	5
10	R:R:L25	R:R:L28	5.54	No	No	0	3	5
11	R:R:I282	R:R:L25	2.85	Yes	No	0	2	3
12	R:R:I27	R:R:L28	2.85	No	No	0	6	5
13	R:R:L28	R:R:P29	4.93	No	No	0	5	5
14	R:R:P286	R:R:P29	9.74	No	No	0	6	5
15	R:R:P29	R:R:S289	3.56	No	No	0	5	5
16	R:R:I82	R:R:L30	4.28	No	No	0	7	5
17	R:R:L30	R:R:M85	2.83	No	No	0	5	6
18	R:R:S289	R:R:V32	3.23	No	No	0	5	5
19	R:R:I82	R:R:L33	5.71	No	Yes	0	7	7
20	R:R:L33	R:R:M85	4.24	Yes	No	0	7	6
21	R:R:L33	R:R:S289	7.51	Yes	No	0	7	5
22	R:R:F292	R:R:L33	4.87	Yes	Yes	0	7	7
23	R:R:L39	R:R:V35	5.96	No	No	0	5	5
24	R:R:L78	R:R:T36	2.95	Yes	No	0	8	7
25	R:R:F293	R:R:T36	5.19	No	No	0	5	7
26	R:R:F37	R:R:P79	15.89	No	No	0	6	8
27	R:R:C296	R:R:G40	3.92	No	No	0	8	8
28	R:R:F72	R:R:V41	2.62	No	No	0	7	6
29	R:R:F304	R:R:G43	3.01	Yes	No	0	7	8
30	R:R:D71	R:R:N44	9.42	Yes	No	0	9	9
31	R:R:N44	R:R:P299	13.03	No	No	0	9	9
32	R:R:F304	R:R:L46	3.65	Yes	No	0	7	6
33	R:R:A68	R:R:V47	5.09	No	Yes	0	8	9
34	R:R:V303	R:R:V47	6.41	No	Yes	2	7	9
35	R:R:F309	R:R:V47	3.93	Yes	Yes	2	8	9
36	R:R:I48	R:R:L65	4.28	No	No	0	7	5
37	R:R:I48	R:R:L69	4.28	No	No	0	7	6
38	R:R:S316	R:R:W49	4.94	No	No	6	5	4
39	R:R:L317	R:R:W49	6.83	No	No	6	5	4
40	R:R:M55	R:R:V50	3.04	No	Yes	2	5	7
41	R:R:F309	R:R:V50	10.49	Yes	Yes	2	8	7
42	R:R:R312	R:R:V50	2.62	No	Yes	2	5	7
43	R:R:M55	R:R:R312	7.44	No	No	2	5	5
44	R:R:R57	R:R:V139	2.62	No	No	0	6	3
45	R:R:T58	R:R:T61	3.14	No	No	0	7	7
46	R:R:R137	R:R:V59	10.46	Yes	No	0	7	6
47	R:R:A142	R:R:V59	5.09	No	No	0	7	6
48	R:R:T60	R:R:Y64	6.24	No	No	0	7	8
49	R:R:I62	R:R:M143	5.83	No	No	0	7	4
50	R:R:C63	R:R:F118	2.79	Yes	No	0	7	7
51	R:R:C63	R:R:I119	3.27	Yes	No	0	7	9
52	R:R:R123	R:R:Y64	5.14	Yes	No	0	9	8
53	R:R:V303	R:R:Y64	7.57	No	No	0	7	8
54	R:R:L115	R:R:N66	2.75	No	No	7	8	9
55	R:R:I146	R:R:N66	7.08	No	No	7	7	9
56	R:R:D71	R:R:L67	5.43	Yes	No	0	9	9
57	R:R:I116	R:R:L67	5.71	Yes	No	0	8	9
58	R:R:A70	R:R:W150	2.59	No	Yes	0	8	9
59	R:R:D71	R:R:S112	2.94	Yes	No	0	9	9
60	R:R:D71	R:R:S295	4.42	Yes	No	0	9	9
61	R:R:D71	R:R:N298	2.69	Yes	Yes	0	9	9
62	R:R:N108	R:R:S73	10.43	Yes	No	0	8	7
63	R:R:F74	R:R:L78	15.83	Yes	Yes	5	7	8
64	R:R:F74	R:R:V105	2.62	Yes	No	0	7	6
65	R:R:F292	R:R:F74	11.79	Yes	Yes	5	7	7
66	R:R:F74	R:R:S295	6.61	Yes	No	0	7	9
67	R:R:L78	R:R:T75	2.95	Yes	No	0	8	7
68	R:R:I101	R:R:T77	7.6	No	No	0	5	7
69	R:R:T77	R:R:V104	7.93	No	No	0	7	5
70	R:R:T77	R:R:V105	4.76	No	No	0	7	6
71	R:R:F292	R:R:L78	3.65	Yes	Yes	5	7	8
72	R:R:F80	R:R:I101	6.28	No	No	0	6	5
73	R:R:F292	R:R:L81	2.44	Yes	No	0	7	6
74	R:R:P92	R:R:V83	3.53	No	No	8	3	5
75	R:R:F93	R:R:V83	3.93	Yes	No	8	7	5
76	R:R:M85	R:R:N285	4.21	No	No	0	6	4
77	R:R:K90	R:R:M87	10.08	No	No	0	4	4
78	R:R:D173	R:R:K90	19.36	No	No	0	3	4
79	R:R:C98	R:R:W91	11.75	No	No	0	9	9
80	R:R:H102	R:R:W91	11.64	No	No	0	6	9
81	R:R:F93	R:R:P92	8.67	Yes	No	8	7	3
82	R:R:T165	R:R:W95	3.64	No	No	0	4	4
83	R:R:T166	R:R:W95	7.28	No	No	0	5	4
84	R:R:F96	R:R:L97	2.44	No	No	0	1	7
85	R:R:F161	R:R:K99	14.89	No	No	0	4	7
86	R:R:K99	R:R:L164	7.05	No	Yes	0	7	5
87	R:R:H102	R:R:L164	3.86	No	Yes	0	6	5
88	R:R:F161	R:R:I103	15.07	No	No	0	4	5
89	R:R:N108	R:R:V104	4.43	Yes	No	0	8	5
90	R:R:D106	R:R:F110	14.33	No	No	3	5	7
91	R:R:D106	R:R:T157	8.67	No	No	0	5	7
92	R:R:I107	R:R:N108	5.66	No	Yes	0	5	8
93	R:R:A153	R:R:I107	3.25	No	No	0	8	5
94	R:R:I107	R:R:L154	2.85	No	No	0	5	4
95	R:R:L109	R:R:W254	3.42	No	Yes	0	8	9
96	R:R:F292	R:R:L109	2.44	Yes	No	0	7	8
97	R:R:F110	R:R:L156	8.53	No	No	0	7	5
98	R:R:G111	R:R:W150	4.22	No	Yes	0	7	9
99	R:R:P213	R:R:V113	3.53	Yes	No	0	9	7
100	R:R:F250	R:R:V113	2.62	Yes	No	1	9	7
101	R:R:V113	R:R:W254	3.68	No	Yes	1	7	9
102	R:R:F114	R:R:L152	9.74	No	No	0	6	4
103	R:R:F114	R:R:I208	2.51	No	Yes	0	6	5
104	R:R:F114	R:R:P213	2.89	No	Yes	0	6	9
105	R:R:I146	R:R:L115	2.85	No	No	7	7	8
106	R:R:F250	R:R:I116	3.77	Yes	Yes	1	9	8
107	R:R:I116	R:R:N298	8.5	Yes	Yes	1	8	9
108	R:R:I116	R:R:Y302	10.88	Yes	Yes	1	8	9
109	R:R:F118	R:R:V145	2.62	No	No	0	7	5
110	R:R:F118	R:R:I146	5.02	No	No	0	7	7
111	R:R:I119	R:R:R123	5.01	No	Yes	1	9	9
112	R:R:I119	R:R:Y302	3.63	No	Yes	1	9	9
113	R:R:A120	R:R:Y221	4	No	Yes	0	9	8
114	R:R:D122	R:R:R137	8.34	No	Yes	0	8	7
115	R:R:R123	R:R:Y221	7.2	Yes	Yes	1	9	8
116	R:R:R123	R:R:Y302	6.17	Yes	Yes	1	9	9
117	R:R:C124	R:R:L128	3.17	No	Yes	0	8	7
118	R:R:C124	R:R:C220	7.28	No	Yes	0	8	7
119	R:R:C126	R:R:R137	6.96	No	Yes	0	8	7
120	R:R:I224	R:R:V127	7.68	No	No	0	8	8
121	R:R:L128	R:R:L223	4.15	Yes	No	0	7	3
122	R:R:K227	R:R:L128	5.64	No	Yes	0	5	7
123	R:R:H136	R:R:W132	12.7	No	No	0	3	5
124	R:R:A133	R:R:R137	2.77	No	Yes	0	5	7
125	R:R:H136	R:R:N135	5.1	No	No	0	3	4
126	R:R:S140	R:R:T138	4.8	No	No	0	4	6
127	R:R:G148	R:R:P149	4.06	No	No	0	3	7
128	R:R:I204	R:R:L156	2.85	No	No	0	4	5
129	R:R:I208	R:R:L156	2.85	Yes	No	0	5	5
130	R:R:T157	R:R:V160	3.17	No	No	0	7	4
131	R:R:L164	R:R:V160	4.47	Yes	No	0	5	4
132	R:R:F163	R:R:L162	3.65	No	No	0	5	5
133	R:R:F163	R:R:F180	31.08	No	No	0	5	6
134	R:R:F163	R:R:W183	4.01	No	No	0	5	4
135	R:R:F178	R:R:L164	4.87	No	Yes	0	4	5
136	R:R:T168	R:R:T174	6.28	No	No	0	2	5
137	R:R:I169	R:R:P170	3.39	No	No	0	1	3
138	R:R:I169	R:R:N171	4.25	No	No	0	1	4
139	R:R:I169	R:R:Y175	12.09	No	Yes	0	1	3
140	R:R:D173	R:R:T174	2.89	No	No	0	3	5
141	R:R:D173	R:R:Y175	3.45	No	Yes	0	3	3
142	R:R:T177	R:R:Y175	8.74	No	Yes	3	3	3
143	R:R:F178	R:R:R201	4.28	No	No	0	4	5
144	R:R:A194	R:R:F180	2.77	No	No	0	3	6
145	R:R:F180	R:R:M197	4.98	No	No	0	6	1
146	R:R:A181	R:R:R190	2.77	No	No	0	5	5
147	R:R:S182	R:R:W183	9.88	No	No	0	7	4
148	R:R:G184	R:R:R190	9.01	No	No	0	3	5
149	R:R:E189	R:R:T186	2.82	No	No	0	3	6
150	R:R:P187	R:R:R190	12.97	No	No	0	5	5
151	R:R:E189	R:R:V193	7.13	No	No	0	3	4
152	R:R:I195	R:R:L191	4.28	No	No	0	1	1
153	R:R:F273	R:R:L191	3.65	Yes	No	0	5	1
154	R:R:T196	R:R:V193	3.17	No	No	0	1	4
155	R:R:I195	R:R:K269	5.82	No	No	0	1	4
156	R:R:L198	R:R:M197	4.24	No	No	0	4	1
157	R:R:L198	R:R:L268	2.77	No	No	0	4	3
158	R:R:G202	R:R:R201	3	No	No	0	4	5
159	R:R:G202	R:R:T265	5.46	No	No	0	4	4
160	R:R:Q258	R:R:R205	4.67	Yes	No	0	8	5
161	R:R:A261	R:R:R205	4.15	No	No	0	5	5
162	R:R:F206	R:R:S211	2.64	No	No	0	6	4
163	R:R:F206	R:R:L262	18.27	No	No	0	6	5
164	R:R:I208	R:R:V207	3.07	Yes	No	0	5	4
165	R:R:G209	R:R:I208	3.53	No	Yes	0	6	5
166	R:R:G209	R:R:P213	4.06	No	Yes	0	6	9
167	R:R:F210	R:R:M214	2.49	No	No	0	9	6
168	R:R:F210	R:R:F255	6.43	No	Yes	0	9	6
169	R:R:F210	R:R:Q258	15.23	No	Yes	0	9	8
170	R:R:L212	R:R:P213	3.28	No	Yes	0	5	9
171	R:R:F250	R:R:M214	4.98	Yes	No	0	9	6
172	R:R:F251	R:R:M214	8.71	No	No	0	6	6
173	R:R:V217	R:R:Y221	3.79	No	Yes	0	8	8
174	R:R:I224	R:R:Y221	4.84	No	Yes	1	8	8
175	R:R:L243	R:R:Y221	8.21	No	Yes	1	8	8
176	R:R:V246	R:R:Y221	10.09	No	Yes	0	8	8
177	R:R:V247	R:R:Y221	3.79	No	Yes	0	8	8
178	R:R:I224	R:R:L243	2.85	No	No	1	8	8
179	R:R:A225	R:R:L243	3.15	No	No	0	5	8
180	R:R:K227	R:R:K231	5.75	No	No	0	5	5
181	R:R:I228	R:R:I234	4.42	No	No	0	8	4
182	R:R:I228	R:R:P239	3.39	No	No	0	8	7
183	R:R:H229	R:R:I234	3.98	No	No	0	3	4
184	R:R:K231	R:R:M233	4.32	No	No	0	5	3
185	R:R:R238	R:R:S236	3.95	No	No	0	7	6
186	R:R:R241	R:R:S237	6.59	No	No	0	5	4
187	R:R:L301	R:R:V246	2.98	Yes	No	0	8	8
188	R:R:V246	R:R:Y302	5.05	No	Yes	0	8	9
189	R:R:L297	R:R:S249	3	No	No	9	6	7
190	R:R:L301	R:R:S249	3	Yes	No	9	8	7
191	R:R:F250	R:R:W254	4.01	Yes	Yes	1	9	9
192	R:R:F251	R:R:F255	12.86	No	Yes	0	6	6
193	R:R:C253	R:R:N294	9.45	No	No	0	8	9
194	R:R:F257	R:R:W254	4.01	Yes	Yes	1	7	9
195	R:R:Q258	R:R:W254	4.38	Yes	Yes	1	8	9
196	R:R:A291	R:R:W254	6.48	No	Yes	1	8	9
197	R:R:N294	R:R:W254	9.04	No	Yes	0	9	9
198	R:R:F255	R:R:P256	4.33	Yes	No	0	6	9
199	R:R:F255	R:R:L259	2.44	Yes	No	0	6	5
200	R:R:F257	R:R:Q258	5.86	Yes	Yes	1	7	8
201	R:R:F257	R:R:T287	2.59	Yes	No	0	7	7
202	R:R:F257	R:R:S288	6.61	Yes	No	0	7	6
203	R:R:A291	R:R:F257	4.16	No	Yes	1	8	7
204	R:R:L259	R:R:L263	2.77	No	No	0	5	5
205	R:R:T287	R:R:V260	4.76	No	No	0	7	5
206	R:R:L262	R:R:V266	2.98	No	No	0	5	4
207	R:R:L263	R:R:W267	7.97	No	No	0	5	3
208	R:R:G264	R:R:I280	3.53	No	No	0	4	4
209	R:R:V266	R:R:W267	3.68	No	No	0	4	3
210	R:R:W267	R:R:Y277	8.68	No	No	0	3	3
211	R:R:L268	R:R:L272	2.77	No	No	0	3	3
212	R:R:E270	R:R:K269	4.05	No	No	0	2	4
213	R:R:F273	R:R:K269	3.72	Yes	No	0	5	4
214	R:R:E270	R:R:K276	8.1	No	No	0	2	1
215	R:R:F273	R:R:L272	9.74	Yes	No	0	5	3
216	R:R:K276	R:R:Y277	15.53	No	No	0	1	3
217	R:R:I279	R:R:I282	2.94	No	Yes	4	3	2
218	R:R:I279	R:R:L283	4.28	No	No	4	3	6
219	R:R:D281	R:R:I282	4.2	No	Yes	0	4	2
220	R:R:I282	R:R:L283	2.85	Yes	No	4	2	6
221	R:R:N285	R:R:V284	4.43	No	No	0	4	5
222	R:R:F292	R:R:S288	2.64	Yes	No	0	7	6
223	R:R:N294	R:R:N298	9.54	No	Yes	0	9	9
224	R:R:L297	R:R:L301	2.77	No	Yes	9	6	8
225	R:R:N298	R:R:Y302	8.14	Yes	Yes	1	9	9
226	R:R:F309	R:R:V303	7.87	Yes	No	2	8	7
227	R:R:F304	R:R:F309	6.43	Yes	Yes	0	7	8
228	R:R:L317	R:R:S316	3	No	No	6	5	5
229	R:R:I125	R:R:W132	2.35	No	No	0	5	5
230	R:R:N66	R:R:W150	2.26	No	Yes	0	9	9
231	R:R:N108	R:R:W150	2.26	Yes	Yes	0	8	9
232	R:R:F80	R:R:F93	2.14	No	Yes	0	6	7
233	R:R:G184	R:R:G185	2.11	No	No	0	3	3
234	R:R:F273	R:R:Y274	2.06	Yes	No	0	5	5
235	R:R:F53	R:R:W49	2	No	No	0	4	4
236	R:R:A51	R:R:G52	1.95	No	Yes	0	7	4
237	R:R:A225	R:R:G222	1.95	No	No	0	5	3
238	R:R:G148	R:R:V147	1.84	No	No	0	3	4
239	R:R:G306	R:R:V305	1.84	No	No	0	8	7
240	R:R:G40	R:R:T75	1.82	No	No	0	8	7
241	R:R:A120	R:R:C220	1.81	No	Yes	0	9	7
242	L:L:?1	R:R:V167	1.78	Yes	No	0	0	1
243	R:R:P130	R:R:V131	1.77	No	No	0	8	5
244	R:R:G34	R:R:I82	1.76	No	No	0	5	7
245	R:R:G45	R:R:I48	1.76	No	No	0	4	7
246	R:R:G117	R:R:I116	1.76	No	Yes	0	7	8
247	R:R:P187	R:R:T186	1.75	No	No	0	5	6
248	R:R:G232	R:R:M233	1.75	No	No	0	4	3
249	R:R:G264	R:R:M271	1.75	No	No	0	4	1
250	R:R:G40	R:R:L39	1.71	No	No	0	8	5
251	R:R:G43	R:R:L42	1.71	No	No	0	8	4
252	R:R:G52	R:R:L65	1.71	Yes	No	0	4	5
253	R:R:C63	R:R:V59	1.71	Yes	No	0	7	6
254	R:R:G94	R:R:L97	1.71	No	No	0	8	7
255	R:R:A51	R:R:V47	1.7	No	Yes	0	7	9
256	R:R:G172	R:R:N171	1.7	No	No	0	4	4
257	R:R:A51	R:R:T61	1.68	No	No	0	7	7
258	R:R:D308	R:R:G306	1.68	No	No	0	6	8
259	R:R:C63	R:R:I62	1.64	Yes	No	0	7	7
260	R:R:L78	R:R:P79	1.64	Yes	No	0	8	8
261	R:R:E89	R:R:G88	1.64	No	No	0	4	3
262	R:R:L115	R:R:P149	1.64	No	No	0	8	7
263	R:R:L158	R:R:P159	1.64	No	No	0	4	8
264	R:R:C220	R:R:I216	1.64	Yes	No	0	7	6
265	R:R:C253	R:R:I252	1.64	No	No	0	8	6
266	R:R:S236	R:R:S237	1.63	No	No	0	6	4
267	R:R:A226	R:R:K230	1.61	No	No	0	3	4
268	R:R:V242	R:R:V305	1.6	No	No	0	8	7
269	R:R:T75	R:R:V41	1.59	No	No	0	7	6
270	R:R:C220	R:R:L121	1.59	Yes	No	0	7	7
271	R:R:T165	R:R:V167	1.59	No	No	0	4	1
272	R:R:A245	R:R:L301	1.58	No	Yes	0	6	8
273	R:R:A181	R:R:N179	1.56	No	No	0	5	3
274	R:R:I27	R:R:V31	1.54	No	No	0	6	6
275	R:R:I203	R:R:V207	1.54	No	No	0	4	4
276	R:R:I280	R:R:V260	1.54	No	No	0	4	5
277	R:R:H129	R:R:P130	1.53	No	No	0	6	8
278	R:R:K144	R:R:V145	1.52	No	No	0	1	5
279	R:R:I195	R:R:T199	1.52	No	No	0	1	3
280	R:R:F53	R:R:G52	1.51	No	Yes	0	4	4
281	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
282	R:R:F309	R:R:G306	1.51	Yes	No	0	8	8
283	R:R:G52	R:R:R57	1.5	Yes	No	0	4	6
284	R:R:L39	R:R:V38	1.49	No	No	0	5	5
285	R:R:L42	R:R:V38	1.49	No	No	0	4	5
286	R:R:L313	R:R:V50	1.49	No	Yes	0	6	7
287	R:R:L152	R:R:V155	1.49	No	No	0	4	4
288	R:R:N135	R:R:V131	1.48	No	No	0	4	5
289	R:R:L141	R:R:T138	1.47	No	No	0	3	6
290	R:R:P239	R:R:R238	1.44	No	No	0	7	7
291	R:R:I103	R:R:L100	1.43	No	No	0	5	5
292	R:R:I219	R:R:L223	1.43	No	No	0	3	3
293	R:R:E188	R:R:T186	1.41	No	No	0	3	6
294	R:R:A86	R:R:R26	1.38	No	No	0	4	4
295	R:R:L158	R:R:L162	1.38	No	No	0	4	5
296	R:R:E189	R:R:K192	1.35	No	No	0	3	5
297	R:R:R54	R:R:S316	1.32	No	No	0	4	5
298	R:R:R238	R:R:V305	1.31	No	No	0	7	7
299	R:R:H129	R:R:L128	1.29	No	Yes	0	6	7
300	R:R:I27	R:R:R26	1.25	No	No	0	6	4
301	R:R:F304	R:R:M300	1.24	Yes	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.542	10	3	0
2	R:R:L33	5.5825	4	0	7
3	R:R:V47	4.2825	4	2	9
4	R:R:V50	4.41	4	2	7
5	R:R:G52	1.6675	4	0	4
6	R:R:C63	2.3525	4	0	7
7	R:R:D71	4.98	5	0	9
8	R:R:F74	9.2125	4	5	7
9	R:R:L78	5.404	5	5	8
10	R:R:F93	4.0625	4	8	7
11	R:R:N108	5.695	4	0	8
12	R:R:I116	6.124	5	1	8
13	R:R:R123	5.88	4	1	9
14	R:R:L128	3.5625	4	0	7
15	R:R:R137	7.1325	4	0	7
16	R:R:W150	2.8325	4	0	9
17	R:R:L164	5.0625	4	0	5
18	R:R:Y175	9.7375	4	3	3
19	R:R:I208	2.99	4	0	5
20	R:R:P213	3.44	4	0	9
21	R:R:C220	3.08	4	0	7
22	R:R:Y221	5.98857	7	1	8
23	R:R:F250	3.845	4	1	9
24	R:R:W254	5.00286	7	1	9
25	R:R:F255	6.515	4	0	6
26	R:R:F257	4.646	5	1	7
27	R:R:Q258	7.535	4	1	8
28	R:R:F273	4.7925	4	0	5
29	R:R:I282	3.21	4	4	2
30	R:R:F292	4.63833	6	5	7
31	R:R:N298	7.2175	4	1	9
32	R:R:L301	2.5825	4	9	8
33	R:R:Y302	6.774	5	1	9
34	R:R:F304	3.5825	4	0	7
35	R:R:F309	6.046	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R205	96.526	9.41	Yes	No	0	0	5
2	R:R:Q258	R:R:R205	100	4.67	Yes	No	0	8	5
3	R:R:Q258	R:R:W254	88.2644	4.38	Yes	Yes	1	8	9
4	R:R:L109	R:R:W254	56.7074	3.42	No	Yes	0	8	9
5	R:R:F292	R:R:L109	55.3659	2.44	Yes	No	0	7	8
6	R:R:F292	R:R:L33	61.8327	4.87	Yes	Yes	0	7	7
7	R:R:L33	R:R:S289	40.1471	7.51	Yes	No	0	7	5
8	R:R:P29	R:R:S289	34.5222	3.56	No	No	0	5	5
9	R:R:L28	R:R:P29	28.8602	4.93	No	No	0	5	5
10	R:R:L25	R:R:L28	14.5434	5.54	No	No	0	3	5
11	R:R:F257	R:R:Q258	26.848	5.86	Yes	Yes	1	7	8
12	R:R:F257	R:R:S288	27.1302	6.61	Yes	No	0	7	6
13	R:R:F292	R:R:S288	25.8858	2.64	Yes	No	0	7	6
14	R:R:I282	R:R:L25	11.6523	2.85	Yes	No	0	2	3
15	R:R:I27	R:R:L28	11.6523	2.85	No	No	0	6	5
16	R:R:L33	R:R:M85	11.1759	4.24	Yes	No	0	7	6
17	R:R:F292	R:R:L78	17.8786	3.65	Yes	Yes	5	7	8
18	R:R:L78	R:R:T75	17.2495	2.95	Yes	No	0	8	7
19	R:R:G40	R:R:T75	13.0169	1.82	No	No	0	8	7
20	R:R:G40	R:R:L39	10.186	1.71	No	No	0	8	5
21	R:R:F250	R:R:W254	48.2931	4.01	Yes	Yes	1	9	9
22	R:R:F250	R:R:I116	99.2275	3.77	Yes	Yes	1	9	8
23	R:R:I116	R:R:Y302	94.3381	10.88	Yes	Yes	1	8	9
24	R:R:R123	R:R:Y302	96.0635	6.17	Yes	Yes	1	9	9
25	R:R:R123	R:R:Y64	68.0359	5.14	Yes	No	0	9	8
26	R:R:V303	R:R:Y64	65.1725	7.57	No	No	0	7	8
27	R:R:F309	R:R:V303	34.3649	7.87	Yes	No	2	8	7
28	R:R:F304	R:R:F309	10.5791	6.43	Yes	Yes	0	7	8
29	R:R:N294	R:R:W254	51.2397	9.04	No	Yes	0	9	9
30	R:R:N294	R:R:N298	50.976	9.54	No	Yes	0	9	9
31	R:R:N298	R:R:Y302	72.5738	8.14	Yes	Yes	1	9	9
32	R:R:D71	R:R:N298	29.9796	2.69	Yes	Yes	0	9	9
33	R:R:V303	R:R:V47	29.2765	6.41	No	Yes	2	7	9
34	R:R:A51	R:R:V47	28.3375	1.7	No	Yes	0	7	9
35	R:R:A51	R:R:G52	22.7449	1.95	No	Yes	0	7	4
36	R:R:I119	R:R:Y302	25.8257	3.63	No	Yes	1	9	9
37	R:R:C63	R:R:I119	33.2778	3.27	Yes	No	0	7	9
38	R:R:C63	R:R:V59	11.0834	1.71	Yes	No	0	7	6
39	R:R:C63	R:R:F118	18.7621	2.79	Yes	No	0	7	7
40	R:R:F118	R:R:I146	13.9097	5.02	No	No	0	7	7
41	R:R:F292	R:R:F74	35.7989	11.79	Yes	Yes	5	7	7
42	R:R:F74	R:R:V105	29.0175	2.62	Yes	No	0	7	6
43	R:R:T77	R:R:V105	27.4262	4.76	No	No	0	7	6
44	R:R:T77	R:R:V104	13.4379	7.93	No	No	0	7	5
45	R:R:N108	R:R:V104	12.1473	4.43	Yes	No	0	8	5
46	R:R:F74	R:R:S295	25.4371	6.61	Yes	No	0	7	9
47	R:R:D71	R:R:S295	26.0801	4.42	Yes	No	0	9	9
48	R:R:I101	R:R:T77	14.4648	7.6	No	No	0	5	7
49	R:R:F80	R:R:I101	12.6885	6.28	No	No	0	6	5
50	R:R:F80	R:R:F93	10.8983	2.14	No	Yes	0	6	7
51	L:L:?1	R:R:Y175	19.5069	14.67	Yes	Yes	3	0	3
52	R:R:D173	R:R:Y175	11.1435	3.45	No	Yes	0	3	3
53	L:L:?1	R:R:R201	25.525	5.79	Yes	No	0	0	5
54	R:R:F178	R:R:R201	19.0952	4.28	No	No	0	4	5
55	R:R:F178	R:R:L164	17.1986	4.87	No	Yes	0	4	5
56	R:R:F114	R:R:P213	11.384	2.89	No	Yes	0	6	9
57	R:R:P213	R:R:V113	21.9586	3.53	Yes	No	0	9	7
58	R:R:R123	R:R:Y221	48.6308	7.2	Yes	Yes	1	9	8
59	R:R:A120	R:R:Y221	62.6099	4	No	Yes	0	9	8
60	R:R:V246	R:R:Y302	47.3494	5.05	No	Yes	0	8	9
61	R:R:V246	R:R:Y221	40.0777	10.09	No	Yes	0	8	8
62	R:R:A120	R:R:C220	59.6124	1.81	No	Yes	0	9	7
63	R:R:C124	R:R:C220	49.8844	7.28	No	Yes	0	8	7
64	R:R:C124	R:R:L128	46.6232	3.17	No	Yes	0	8	7
65	R:R:K227	R:R:L128	13.498	5.64	No	Yes	0	5	7
66	R:R:H129	R:R:L128	23.5359	1.29	No	Yes	0	6	7
67	R:R:H129	R:R:P130	20.2008	1.53	No	No	0	6	8
68	R:R:P130	R:R:V131	16.8563	1.77	No	No	0	8	5
69	R:R:N135	R:R:V131	13.5026	1.48	No	No	0	4	5
70	R:R:H136	R:R:N135	10.1397	5.1	No	No	0	3	4
71	R:R:F210	R:R:Q258	31.3396	15.23	No	Yes	0	9	8
72	R:R:F210	R:R:F255	51.4617	6.43	No	Yes	0	9	6
73	R:R:F255	R:R:L259	68.3134	2.44	Yes	No	0	6	5
74	R:R:L259	R:R:L263	66.0468	2.77	No	No	0	5	5
75	R:R:L263	R:R:W267	63.7709	7.97	No	No	0	5	3
76	R:R:W267	R:R:Y277	52.2528	8.68	No	No	0	3	3
77	R:R:K276	R:R:Y277	49.9214	15.53	No	No	0	1	3
78	R:R:E270	R:R:K276	47.5807	8.1	No	No	0	2	1
79	R:R:E270	R:R:K269	45.2308	4.05	No	No	0	2	4
80	R:R:F273	R:R:K269	35.896	3.72	Yes	No	0	5	4
81	R:R:F273	R:R:L272	29.0406	9.74	Yes	No	0	5	3
82	R:R:L268	R:R:L272	26.6121	2.77	No	No	0	3	3
83	R:R:L198	R:R:L268	24.165	2.77	No	No	0	4	3
84	R:R:L198	R:R:M197	21.9539	4.24	No	No	0	4	1
85	R:R:F180	R:R:M197	19.4884	4.98	No	No	0	6	1
86	R:R:F163	R:R:F180	14.7886	31.08	No	No	0	5	6
87	L:L:?1	R:R:N179	26.1911	8.18	Yes	No	0	0	3
88	R:R:A181	R:R:N179	24.3177	1.56	No	No	0	5	3
89	R:R:A181	R:R:R190	22.1528	2.77	No	No	0	5	5
90	R:R:P187	R:R:R190	15.6027	12.97	No	No	0	5	5
91	R:R:P187	R:R:T186	13.4009	1.75	No	No	0	5	6
92	R:R:V266	R:R:W267	10.0426	3.68	No	No	0	4	3
93	R:R:F210	R:R:M214	22.7727	2.49	No	No	0	9	6
94	R:R:F251	R:R:M214	22.8282	8.71	No	No	0	6	6
95	R:R:F251	R:R:F255	21.9262	12.86	No	Yes	0	6	6
96	R:R:K227	R:R:K231	10.1397	5.75	No	No	0	5	5
97	R:R:F309	R:R:G306	23.5221	1.51	Yes	No	0	8	8
98	R:R:G306	R:R:V305	19.5717	1.84	No	No	0	8	7
99	R:R:R238	R:R:V305	15.8202	1.31	No	No	0	7	7
100	R:R:F250	R:R:M214	45.4945	4.98	Yes	No	0	9	6
101	R:R:F250	R:R:V113	14.8719	2.62	Yes	No	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:E89	8.68	3	Yes	No	0	4	0	1
L:L:?1	R:R:D106	4.04	3	Yes	No	0	5	0	1
L:L:?1	R:R:F110	2.9	3	Yes	No	0	7	0	1
L:L:?1	R:R:P170	2.94	3	Yes	No	0	3	0	1
L:L:?1	R:R:Y175	14.67	3	Yes	Yes	0	3	0	1
L:L:?1	R:R:T177	7.03	3	Yes	No	0	3	0	1
L:L:?1	R:R:N179	8.18	3	Yes	No	0	3	0	1
L:L:?1	R:R:R201	5.79	3	Yes	No	0	5	0	1
L:L:?1	R:R:R205	9.41	3	Yes	No	0	5	0	1
R:R:D106	R:R:F110	14.33	3	No	No	5	7	1	1
R:R:D106	R:R:T157	8.67	3	No	No	5	7	1	2
R:R:F110	R:R:L156	8.53	3	No	No	7	5	1	2
R:R:I169	R:R:P170	3.39	0	No	No	1	3	2	1
R:R:I169	R:R:Y175	12.09	0	No	Yes	1	3	2	1
R:R:D173	R:R:Y175	3.45	0	No	Yes	3	3	2	1
R:R:T177	R:R:Y175	8.74	3	No	Yes	3	3	1	1
R:R:F178	R:R:R201	4.28	0	No	No	4	5	2	1
R:R:G202	R:R:R201	3	0	No	No	4	5	2	1
R:R:Q258	R:R:R205	4.67	1	Yes	No	8	5	2	1
R:R:A261	R:R:R205	4.15	0	No	No	5	5	2	1
L:L:?1	R:R:V167	1.78	3	Yes	No	0	1	0	1
R:R:E89	R:R:G88	1.64	0	No	No	4	3	1	2
R:R:T165	R:R:V167	1.59	0	No	No	4	1	2	1
R:R:A181	R:R:N179	1.56	0	No	No	5	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JHJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	273
Number of Links	301
Number of Hubs	35
Number of Links mediated by Hubs	140
Number of Communities	9
Number of Nodes involved in Communities	43
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	67095
Length Of Smallest Path	3
Average Path Length	14.4599
Length of Longest Path	36
Minimum Path Strength	1.315
Average Path Strength	5.47726
Maximum Path Strength	18.03
Minimum Path Correlation	0.7
Average Path Correlation	0.93057
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	46.8262
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.2079
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • amide binding • amyloid-beta binding • binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • RAGE receptor binding • protein binding • signaling receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • negative regulation of biological process • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • response to chemical • locomotion • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of transport • regulation of phagocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • multicellular organismal process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • anatomical structure development • system development • developmental process • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell migration • cell motility • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • cellular response to chemical stimulus • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell adhesion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • defense response to other organism • positive regulation of defense response • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule membrane • specific granule • cell periphery • plasma membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	18C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	18C
Name	N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE
Synonyms	C18-CERAMIDE; N-STEAROYL-D-ERYTHRO-SPHINGOSINE; (2S,3R,4E)-2-STEAROYLAMINOOCTADEC-4-ENE-1,3-DIOL; (2S,3R,4E)-2-STEAROYLAMINO-1,3-OCTADEC-4-ENEDIOL
Identifier
Formula	C36 H71 N O3
Molecular Weight	565.954
SMILES
PubChem	5283565
Formal Charge	0
Total Atoms	111
Total Chiral Atoms	2
Total Bonds	110
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>9JHJ_nogp_Chain_R V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188

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