psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E89	8.68	Yes	No	0	0	4
2	L:L:?1	R:R:D106	4.04	Yes	No	3	0	5
3	L:L:?1	R:R:F110	2.9	Yes	No	3	0	7
4	L:L:?1	R:R:P170	2.94	Yes	No	0	0	3
5	L:L:?1	R:R:Y175	14.67	Yes	Yes	3	0	3
6	L:L:?1	R:R:T177	7.03	Yes	No	3	0	3
7	L:L:?1	R:R:N179	8.18	Yes	No	0	0	3
8	L:L:?1	R:R:R201	5.79	Yes	No	0	0	5
9	L:L:?1	R:R:R205	9.41	Yes	No	0	0	5
10	R:R:L25	R:R:L28	5.54	No	No	0	3	5
11	R:R:I282	R:R:L25	2.85	Yes	No	0	2	3
12	R:R:I27	R:R:L28	2.85	No	No	0	6	5
13	R:R:L28	R:R:P29	4.93	No	No	0	5	5
14	R:R:P286	R:R:P29	9.74	No	No	0	6	5
15	R:R:P29	R:R:S289	3.56	No	No	0	5	5
16	R:R:I82	R:R:L30	4.28	No	No	0	7	5
17	R:R:L30	R:R:M85	2.83	No	No	0	5	6
18	R:R:S289	R:R:V32	3.23	No	No	0	5	5
19	R:R:I82	R:R:L33	5.71	No	Yes	0	7	7
20	R:R:L33	R:R:M85	4.24	Yes	No	0	7	6
21	R:R:L33	R:R:S289	7.51	Yes	No	0	7	5
22	R:R:F292	R:R:L33	4.87	Yes	Yes	0	7	7
23	R:R:L39	R:R:V35	5.96	No	No	0	5	5
24	R:R:L78	R:R:T36	2.95	Yes	No	0	8	7
25	R:R:F293	R:R:T36	5.19	No	No	0	5	7
26	R:R:F37	R:R:P79	15.89	No	No	0	6	8
27	R:R:C296	R:R:G40	3.92	No	No	0	8	8
28	R:R:F72	R:R:V41	2.62	No	No	0	7	6
29	R:R:F304	R:R:G43	3.01	Yes	No	0	7	8
30	R:R:D71	R:R:N44	9.42	Yes	No	0	9	9
31	R:R:N44	R:R:P299	13.03	No	No	0	9	9
32	R:R:F304	R:R:L46	3.65	Yes	No	0	7	6
33	R:R:A68	R:R:V47	5.09	No	Yes	0	8	9
34	R:R:V303	R:R:V47	6.41	No	Yes	2	7	9
35	R:R:F309	R:R:V47	3.93	Yes	Yes	2	8	9
36	R:R:I48	R:R:L65	4.28	No	No	0	7	5
37	R:R:I48	R:R:L69	4.28	No	No	0	7	6
38	R:R:S316	R:R:W49	4.94	No	No	6	5	4
39	R:R:L317	R:R:W49	6.83	No	No	6	5	4
40	R:R:M55	R:R:V50	3.04	No	Yes	2	5	7
41	R:R:F309	R:R:V50	10.49	Yes	Yes	2	8	7
42	R:R:R312	R:R:V50	2.62	No	Yes	2	5	7
43	R:R:M55	R:R:R312	7.44	No	No	2	5	5
44	R:R:R57	R:R:V139	2.62	No	No	0	6	3
45	R:R:T58	R:R:T61	3.14	No	No	0	7	7
46	R:R:R137	R:R:V59	10.46	Yes	No	0	7	6
47	R:R:A142	R:R:V59	5.09	No	No	0	7	6
48	R:R:T60	R:R:Y64	6.24	No	No	0	7	8
49	R:R:I62	R:R:M143	5.83	No	No	0	7	4
50	R:R:C63	R:R:F118	2.79	Yes	No	0	7	7
51	R:R:C63	R:R:I119	3.27	Yes	No	0	7	9
52	R:R:R123	R:R:Y64	5.14	Yes	No	0	9	8
53	R:R:V303	R:R:Y64	7.57	No	No	0	7	8
54	R:R:L115	R:R:N66	2.75	No	No	7	8	9
55	R:R:I146	R:R:N66	7.08	No	No	7	7	9
56	R:R:D71	R:R:L67	5.43	Yes	No	0	9	9
57	R:R:I116	R:R:L67	5.71	Yes	No	0	8	9
58	R:R:A70	R:R:W150	2.59	No	Yes	0	8	9
59	R:R:D71	R:R:S112	2.94	Yes	No	0	9	9
60	R:R:D71	R:R:S295	4.42	Yes	No	0	9	9
61	R:R:D71	R:R:N298	2.69	Yes	Yes	0	9	9
62	R:R:N108	R:R:S73	10.43	Yes	No	0	8	7
63	R:R:F74	R:R:L78	15.83	Yes	Yes	5	7	8
64	R:R:F74	R:R:V105	2.62	Yes	No	0	7	6
65	R:R:F292	R:R:F74	11.79	Yes	Yes	5	7	7
66	R:R:F74	R:R:S295	6.61	Yes	No	0	7	9
67	R:R:L78	R:R:T75	2.95	Yes	No	0	8	7
68	R:R:I101	R:R:T77	7.6	No	No	0	5	7
69	R:R:T77	R:R:V104	7.93	No	No	0	7	5
70	R:R:T77	R:R:V105	4.76	No	No	0	7	6
71	R:R:F292	R:R:L78	3.65	Yes	Yes	5	7	8
72	R:R:F80	R:R:I101	6.28	No	No	0	6	5
73	R:R:F292	R:R:L81	2.44	Yes	No	0	7	6
74	R:R:P92	R:R:V83	3.53	No	No	8	3	5
75	R:R:F93	R:R:V83	3.93	Yes	No	8	7	5
76	R:R:M85	R:R:N285	4.21	No	No	0	6	4
77	R:R:K90	R:R:M87	10.08	No	No	0	4	4
78	R:R:D173	R:R:K90	19.36	No	No	0	3	4
79	R:R:C98	R:R:W91	11.75	No	No	0	9	9
80	R:R:H102	R:R:W91	11.64	No	No	0	6	9
81	R:R:F93	R:R:P92	8.67	Yes	No	8	7	3
82	R:R:T165	R:R:W95	3.64	No	No	0	4	4
83	R:R:T166	R:R:W95	7.28	No	No	0	5	4
84	R:R:F96	R:R:L97	2.44	No	No	0	1	7
85	R:R:F161	R:R:K99	14.89	No	No	0	4	7
86	R:R:K99	R:R:L164	7.05	No	Yes	0	7	5
87	R:R:H102	R:R:L164	3.86	No	Yes	0	6	5
88	R:R:F161	R:R:I103	15.07	No	No	0	4	5
89	R:R:N108	R:R:V104	4.43	Yes	No	0	8	5
90	R:R:D106	R:R:F110	14.33	No	No	3	5	7
91	R:R:D106	R:R:T157	8.67	No	No	0	5	7
92	R:R:I107	R:R:N108	5.66	No	Yes	0	5	8
93	R:R:A153	R:R:I107	3.25	No	No	0	8	5
94	R:R:I107	R:R:L154	2.85	No	No	0	5	4
95	R:R:L109	R:R:W254	3.42	No	Yes	0	8	9
96	R:R:F292	R:R:L109	2.44	Yes	No	0	7	8
97	R:R:F110	R:R:L156	8.53	No	No	0	7	5
98	R:R:G111	R:R:W150	4.22	No	Yes	0	7	9
99	R:R:P213	R:R:V113	3.53	Yes	No	0	9	7
100	R:R:F250	R:R:V113	2.62	Yes	No	1	9	7
101	R:R:V113	R:R:W254	3.68	No	Yes	1	7	9
102	R:R:F114	R:R:L152	9.74	No	No	0	6	4
103	R:R:F114	R:R:I208	2.51	No	Yes	0	6	5
104	R:R:F114	R:R:P213	2.89	No	Yes	0	6	9
105	R:R:I146	R:R:L115	2.85	No	No	7	7	8
106	R:R:F250	R:R:I116	3.77	Yes	Yes	1	9	8
107	R:R:I116	R:R:N298	8.5	Yes	Yes	1	8	9
108	R:R:I116	R:R:Y302	10.88	Yes	Yes	1	8	9
109	R:R:F118	R:R:V145	2.62	No	No	0	7	5
110	R:R:F118	R:R:I146	5.02	No	No	0	7	7
111	R:R:I119	R:R:R123	5.01	No	Yes	1	9	9
112	R:R:I119	R:R:Y302	3.63	No	Yes	1	9	9
113	R:R:A120	R:R:Y221	4	No	Yes	0	9	8
114	R:R:D122	R:R:R137	8.34	No	Yes	0	8	7
115	R:R:R123	R:R:Y221	7.2	Yes	Yes	1	9	8
116	R:R:R123	R:R:Y302	6.17	Yes	Yes	1	9	9
117	R:R:C124	R:R:L128	3.17	No	Yes	0	8	7
118	R:R:C124	R:R:C220	7.28	No	Yes	0	8	7
119	R:R:C126	R:R:R137	6.96	No	Yes	0	8	7
120	R:R:I224	R:R:V127	7.68	No	No	0	8	8
121	R:R:L128	R:R:L223	4.15	Yes	No	0	7	3
122	R:R:K227	R:R:L128	5.64	No	Yes	0	5	7
123	R:R:H136	R:R:W132	12.7	No	No	0	3	5
124	R:R:A133	R:R:R137	2.77	No	Yes	0	5	7
125	R:R:H136	R:R:N135	5.1	No	No	0	3	4
126	R:R:S140	R:R:T138	4.8	No	No	0	4	6
127	R:R:G148	R:R:P149	4.06	No	No	0	3	7
128	R:R:I204	R:R:L156	2.85	No	No	0	4	5
129	R:R:I208	R:R:L156	2.85	Yes	No	0	5	5
130	R:R:T157	R:R:V160	3.17	No	No	0	7	4
131	R:R:L164	R:R:V160	4.47	Yes	No	0	5	4
132	R:R:F163	R:R:L162	3.65	No	No	0	5	5
133	R:R:F163	R:R:F180	31.08	No	No	0	5	6
134	R:R:F163	R:R:W183	4.01	No	No	0	5	4
135	R:R:F178	R:R:L164	4.87	No	Yes	0	4	5
136	R:R:T168	R:R:T174	6.28	No	No	0	2	5
137	R:R:I169	R:R:P170	3.39	No	No	0	1	3
138	R:R:I169	R:R:N171	4.25	No	No	0	1	4
139	R:R:I169	R:R:Y175	12.09	No	Yes	0	1	3
140	R:R:D173	R:R:T174	2.89	No	No	0	3	5
141	R:R:D173	R:R:Y175	3.45	No	Yes	0	3	3
142	R:R:T177	R:R:Y175	8.74	No	Yes	3	3	3
143	R:R:F178	R:R:R201	4.28	No	No	0	4	5
144	R:R:A194	R:R:F180	2.77	No	No	0	3	6
145	R:R:F180	R:R:M197	4.98	No	No	0	6	1
146	R:R:A181	R:R:R190	2.77	No	No	0	5	5
147	R:R:S182	R:R:W183	9.88	No	No	0	7	4
148	R:R:G184	R:R:R190	9.01	No	No	0	3	5
149	R:R:E189	R:R:T186	2.82	No	No	0	3	6
150	R:R:P187	R:R:R190	12.97	No	No	0	5	5
151	R:R:E189	R:R:V193	7.13	No	No	0	3	4
152	R:R:I195	R:R:L191	4.28	No	No	0	1	1
153	R:R:F273	R:R:L191	3.65	Yes	No	0	5	1
154	R:R:T196	R:R:V193	3.17	No	No	0	1	4
155	R:R:I195	R:R:K269	5.82	No	No	0	1	4
156	R:R:L198	R:R:M197	4.24	No	No	0	4	1
157	R:R:L198	R:R:L268	2.77	No	No	0	4	3
158	R:R:G202	R:R:R201	3	No	No	0	4	5
159	R:R:G202	R:R:T265	5.46	No	No	0	4	4
160	R:R:Q258	R:R:R205	4.67	Yes	No	0	8	5
161	R:R:A261	R:R:R205	4.15	No	No	0	5	5
162	R:R:F206	R:R:S211	2.64	No	No	0	6	4
163	R:R:F206	R:R:L262	18.27	No	No	0	6	5
164	R:R:I208	R:R:V207	3.07	Yes	No	0	5	4
165	R:R:G209	R:R:I208	3.53	No	Yes	0	6	5
166	R:R:G209	R:R:P213	4.06	No	Yes	0	6	9
167	R:R:F210	R:R:M214	2.49	No	No	0	9	6
168	R:R:F210	R:R:F255	6.43	No	Yes	0	9	6
169	R:R:F210	R:R:Q258	15.23	No	Yes	0	9	8
170	R:R:L212	R:R:P213	3.28	No	Yes	0	5	9
171	R:R:F250	R:R:M214	4.98	Yes	No	0	9	6
172	R:R:F251	R:R:M214	8.71	No	No	0	6	6
173	R:R:V217	R:R:Y221	3.79	No	Yes	0	8	8
174	R:R:I224	R:R:Y221	4.84	No	Yes	1	8	8
175	R:R:L243	R:R:Y221	8.21	No	Yes	1	8	8
176	R:R:V246	R:R:Y221	10.09	No	Yes	0	8	8
177	R:R:V247	R:R:Y221	3.79	No	Yes	0	8	8
178	R:R:I224	R:R:L243	2.85	No	No	1	8	8
179	R:R:A225	R:R:L243	3.15	No	No	0	5	8
180	R:R:K227	R:R:K231	5.75	No	No	0	5	5
181	R:R:I228	R:R:I234	4.42	No	No	0	8	4
182	R:R:I228	R:R:P239	3.39	No	No	0	8	7
183	R:R:H229	R:R:I234	3.98	No	No	0	3	4
184	R:R:K231	R:R:M233	4.32	No	No	0	5	3
185	R:R:R238	R:R:S236	3.95	No	No	0	7	6
186	R:R:R241	R:R:S237	6.59	No	No	0	5	4
187	R:R:L301	R:R:V246	2.98	Yes	No	0	8	8
188	R:R:V246	R:R:Y302	5.05	No	Yes	0	8	9
189	R:R:L297	R:R:S249	3	No	No	9	6	7
190	R:R:L301	R:R:S249	3	Yes	No	9	8	7
191	R:R:F250	R:R:W254	4.01	Yes	Yes	1	9	9
192	R:R:F251	R:R:F255	12.86	No	Yes	0	6	6
193	R:R:C253	R:R:N294	9.45	No	No	0	8	9
194	R:R:F257	R:R:W254	4.01	Yes	Yes	1	7	9
195	R:R:Q258	R:R:W254	4.38	Yes	Yes	1	8	9
196	R:R:A291	R:R:W254	6.48	No	Yes	1	8	9
197	R:R:N294	R:R:W254	9.04	No	Yes	0	9	9
198	R:R:F255	R:R:P256	4.33	Yes	No	0	6	9
199	R:R:F255	R:R:L259	2.44	Yes	No	0	6	5
200	R:R:F257	R:R:Q258	5.86	Yes	Yes	1	7	8
201	R:R:F257	R:R:T287	2.59	Yes	No	0	7	7
202	R:R:F257	R:R:S288	6.61	Yes	No	0	7	6
203	R:R:A291	R:R:F257	4.16	No	Yes	1	8	7
204	R:R:L259	R:R:L263	2.77	No	No	0	5	5
205	R:R:T287	R:R:V260	4.76	No	No	0	7	5
206	R:R:L262	R:R:V266	2.98	No	No	0	5	4
207	R:R:L263	R:R:W267	7.97	No	No	0	5	3
208	R:R:G264	R:R:I280	3.53	No	No	0	4	4
209	R:R:V266	R:R:W267	3.68	No	No	0	4	3
210	R:R:W267	R:R:Y277	8.68	No	No	0	3	3
211	R:R:L268	R:R:L272	2.77	No	No	0	3	3
212	R:R:E270	R:R:K269	4.05	No	No	0	2	4
213	R:R:F273	R:R:K269	3.72	Yes	No	0	5	4
214	R:R:E270	R:R:K276	8.1	No	No	0	2	1
215	R:R:F273	R:R:L272	9.74	Yes	No	0	5	3
216	R:R:K276	R:R:Y277	15.53	No	No	0	1	3
217	R:R:I279	R:R:I282	2.94	No	Yes	4	3	2
218	R:R:I279	R:R:L283	4.28	No	No	4	3	6
219	R:R:D281	R:R:I282	4.2	No	Yes	0	4	2
220	R:R:I282	R:R:L283	2.85	Yes	No	4	2	6
221	R:R:N285	R:R:V284	4.43	No	No	0	4	5
222	R:R:F292	R:R:S288	2.64	Yes	No	0	7	6
223	R:R:N294	R:R:N298	9.54	No	Yes	0	9	9
224	R:R:L297	R:R:L301	2.77	No	Yes	9	6	8
225	R:R:N298	R:R:Y302	8.14	Yes	Yes	1	9	9
226	R:R:F309	R:R:V303	7.87	Yes	No	2	8	7
227	R:R:F304	R:R:F309	6.43	Yes	Yes	0	7	8
228	R:R:L317	R:R:S316	3	No	No	6	5	5
229	R:R:I125	R:R:W132	2.35	No	No	0	5	5
230	R:R:N66	R:R:W150	2.26	No	Yes	0	9	9
231	R:R:N108	R:R:W150	2.26	Yes	Yes	0	8	9
232	R:R:F80	R:R:F93	2.14	No	Yes	0	6	7
233	R:R:G184	R:R:G185	2.11	No	No	0	3	3
234	R:R:F273	R:R:Y274	2.06	Yes	No	0	5	5
235	R:R:F53	R:R:W49	2	No	No	0	4	4
236	R:R:A51	R:R:G52	1.95	No	Yes	0	7	4
237	R:R:A225	R:R:G222	1.95	No	No	0	5	3
238	R:R:G148	R:R:V147	1.84	No	No	0	3	4
239	R:R:G306	R:R:V305	1.84	No	No	0	8	7
240	R:R:G40	R:R:T75	1.82	No	No	0	8	7
241	R:R:A120	R:R:C220	1.81	No	Yes	0	9	7
242	L:L:?1	R:R:V167	1.78	Yes	No	0	0	1
243	R:R:P130	R:R:V131	1.77	No	No	0	8	5
244	R:R:G34	R:R:I82	1.76	No	No	0	5	7
245	R:R:G45	R:R:I48	1.76	No	No	0	4	7
246	R:R:G117	R:R:I116	1.76	No	Yes	0	7	8
247	R:R:P187	R:R:T186	1.75	No	No	0	5	6
248	R:R:G232	R:R:M233	1.75	No	No	0	4	3
249	R:R:G264	R:R:M271	1.75	No	No	0	4	1
250	R:R:G40	R:R:L39	1.71	No	No	0	8	5
251	R:R:G43	R:R:L42	1.71	No	No	0	8	4
252	R:R:G52	R:R:L65	1.71	Yes	No	0	4	5
253	R:R:C63	R:R:V59	1.71	Yes	No	0	7	6
254	R:R:G94	R:R:L97	1.71	No	No	0	8	7
255	R:R:A51	R:R:V47	1.7	No	Yes	0	7	9
256	R:R:G172	R:R:N171	1.7	No	No	0	4	4
257	R:R:A51	R:R:T61	1.68	No	No	0	7	7
258	R:R:D308	R:R:G306	1.68	No	No	0	6	8
259	R:R:C63	R:R:I62	1.64	Yes	No	0	7	7
260	R:R:L78	R:R:P79	1.64	Yes	No	0	8	8
261	R:R:E89	R:R:G88	1.64	No	No	0	4	3
262	R:R:L115	R:R:P149	1.64	No	No	0	8	7
263	R:R:L158	R:R:P159	1.64	No	No	0	4	8
264	R:R:C220	R:R:I216	1.64	Yes	No	0	7	6
265	R:R:C253	R:R:I252	1.64	No	No	0	8	6
266	R:R:S236	R:R:S237	1.63	No	No	0	6	4
267	R:R:A226	R:R:K230	1.61	No	No	0	3	4
268	R:R:V242	R:R:V305	1.6	No	No	0	8	7
269	R:R:T75	R:R:V41	1.59	No	No	0	7	6
270	R:R:C220	R:R:L121	1.59	Yes	No	0	7	7
271	R:R:T165	R:R:V167	1.59	No	No	0	4	1
272	R:R:A245	R:R:L301	1.58	No	Yes	0	6	8
273	R:R:A181	R:R:N179	1.56	No	No	0	5	3
274	R:R:I27	R:R:V31	1.54	No	No	0	6	6
275	R:R:I203	R:R:V207	1.54	No	No	0	4	4
276	R:R:I280	R:R:V260	1.54	No	No	0	4	5
277	R:R:H129	R:R:P130	1.53	No	No	0	6	8
278	R:R:K144	R:R:V145	1.52	No	No	0	1	5
279	R:R:I195	R:R:T199	1.52	No	No	0	1	3
280	R:R:F53	R:R:G52	1.51	No	Yes	0	4	4
281	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
282	R:R:F309	R:R:G306	1.51	Yes	No	0	8	8
283	R:R:G52	R:R:R57	1.5	Yes	No	0	4	6
284	R:R:L39	R:R:V38	1.49	No	No	0	5	5
285	R:R:L42	R:R:V38	1.49	No	No	0	4	5
286	R:R:L313	R:R:V50	1.49	No	Yes	0	6	7
287	R:R:L152	R:R:V155	1.49	No	No	0	4	4
288	R:R:N135	R:R:V131	1.48	No	No	0	4	5
289	R:R:L141	R:R:T138	1.47	No	No	0	3	6
290	R:R:P239	R:R:R238	1.44	No	No	0	7	7
291	R:R:I103	R:R:L100	1.43	No	No	0	5	5
292	R:R:I219	R:R:L223	1.43	No	No	0	3	3
293	R:R:E188	R:R:T186	1.41	No	No	0	3	6
294	R:R:A86	R:R:R26	1.38	No	No	0	4	4
295	R:R:L158	R:R:L162	1.38	No	No	0	4	5
296	R:R:E189	R:R:K192	1.35	No	No	0	3	5
297	R:R:R54	R:R:S316	1.32	No	No	0	4	5
298	R:R:R238	R:R:V305	1.31	No	No	0	7	7
299	R:R:H129	R:R:L128	1.29	No	Yes	0	6	7
300	R:R:I27	R:R:R26	1.25	No	No	0	6	4
301	R:R:F304	R:R:M300	1.24	Yes	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.542	10	3	0
2	R:R:L33	5.5825	4	0	7
3	R:R:V47	4.2825	4	2	9
4	R:R:V50	4.41	4	2	7
5	R:R:G52	1.6675	4	0	4
6	R:R:C63	2.3525	4	0	7
7	R:R:D71	4.98	5	0	9
8	R:R:F74	9.2125	4	5	7
9	R:R:L78	5.404	5	5	8
10	R:R:F93	4.0625	4	8	7
11	R:R:N108	5.695	4	0	8
12	R:R:I116	6.124	5	1	8
13	R:R:R123	5.88	4	1	9
14	R:R:L128	3.5625	4	0	7
15	R:R:R137	7.1325	4	0	7
16	R:R:W150	2.8325	4	0	9
17	R:R:L164	5.0625	4	0	5
18	R:R:Y175	9.7375	4	3	3
19	R:R:I208	2.99	4	0	5
20	R:R:P213	3.44	4	0	9
21	R:R:C220	3.08	4	0	7
22	R:R:Y221	5.98857	7	1	8
23	R:R:F250	3.845	4	1	9
24	R:R:W254	5.00286	7	1	9
25	R:R:F255	6.515	4	0	6
26	R:R:F257	4.646	5	1	7
27	R:R:Q258	7.535	4	1	8
28	R:R:F273	4.7925	4	0	5
29	R:R:I282	3.21	4	4	2
30	R:R:F292	4.63833	6	5	7
31	R:R:N298	7.2175	4	1	9
32	R:R:L301	2.5825	4	9	8
33	R:R:Y302	6.774	5	1	9
34	R:R:F304	3.5825	4	0	7
35	R:R:F309	6.046	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R205	96.526	9.41	Yes	No	0	0	5
2	R:R:Q258	R:R:R205	100	4.67	Yes	No	0	8	5
3	R:R:Q258	R:R:W254	88.2644	4.38	Yes	Yes	1	8	9
4	R:R:L109	R:R:W254	56.7074	3.42	No	Yes	0	8	9
5	R:R:F292	R:R:L109	55.3659	2.44	Yes	No	0	7	8
6	R:R:F292	R:R:L33	61.8327	4.87	Yes	Yes	0	7	7
7	R:R:L33	R:R:S289	40.1471	7.51	Yes	No	0	7	5
8	R:R:P29	R:R:S289	34.5222	3.56	No	No	0	5	5
9	R:R:L28	R:R:P29	28.8602	4.93	No	No	0	5	5
10	R:R:L25	R:R:L28	14.5434	5.54	No	No	0	3	5
11	R:R:F257	R:R:Q258	26.848	5.86	Yes	Yes	1	7	8
12	R:R:F257	R:R:S288	27.1302	6.61	Yes	No	0	7	6
13	R:R:F292	R:R:S288	25.8858	2.64	Yes	No	0	7	6
14	R:R:I282	R:R:L25	11.6523	2.85	Yes	No	0	2	3
15	R:R:I27	R:R:L28	11.6523	2.85	No	No	0	6	5
16	R:R:L33	R:R:M85	11.1759	4.24	Yes	No	0	7	6
17	R:R:F292	R:R:L78	17.8786	3.65	Yes	Yes	5	7	8
18	R:R:L78	R:R:T75	17.2495	2.95	Yes	No	0	8	7
19	R:R:G40	R:R:T75	13.0169	1.82	No	No	0	8	7
20	R:R:G40	R:R:L39	10.186	1.71	No	No	0	8	5
21	R:R:F250	R:R:W254	48.2931	4.01	Yes	Yes	1	9	9
22	R:R:F250	R:R:I116	99.2275	3.77	Yes	Yes	1	9	8
23	R:R:I116	R:R:Y302	94.3381	10.88	Yes	Yes	1	8	9
24	R:R:R123	R:R:Y302	96.0635	6.17	Yes	Yes	1	9	9
25	R:R:R123	R:R:Y64	68.0359	5.14	Yes	No	0	9	8
26	R:R:V303	R:R:Y64	65.1725	7.57	No	No	0	7	8
27	R:R:F309	R:R:V303	34.3649	7.87	Yes	No	2	8	7
28	R:R:F304	R:R:F309	10.5791	6.43	Yes	Yes	0	7	8
29	R:R:N294	R:R:W254	51.2397	9.04	No	Yes	0	9	9
30	R:R:N294	R:R:N298	50.976	9.54	No	Yes	0	9	9
31	R:R:N298	R:R:Y302	72.5738	8.14	Yes	Yes	1	9	9
32	R:R:D71	R:R:N298	29.9796	2.69	Yes	Yes	0	9	9
33	R:R:V303	R:R:V47	29.2765	6.41	No	Yes	2	7	9
34	R:R:A51	R:R:V47	28.3375	1.7	No	Yes	0	7	9
35	R:R:A51	R:R:G52	22.7449	1.95	No	Yes	0	7	4
36	R:R:I119	R:R:Y302	25.8257	3.63	No	Yes	1	9	9
37	R:R:C63	R:R:I119	33.2778	3.27	Yes	No	0	7	9
38	R:R:C63	R:R:V59	11.0834	1.71	Yes	No	0	7	6
39	R:R:C63	R:R:F118	18.7621	2.79	Yes	No	0	7	7
40	R:R:F118	R:R:I146	13.9097	5.02	No	No	0	7	7
41	R:R:F292	R:R:F74	35.7989	11.79	Yes	Yes	5	7	7
42	R:R:F74	R:R:V105	29.0175	2.62	Yes	No	0	7	6
43	R:R:T77	R:R:V105	27.4262	4.76	No	No	0	7	6
44	R:R:T77	R:R:V104	13.4379	7.93	No	No	0	7	5
45	R:R:N108	R:R:V104	12.1473	4.43	Yes	No	0	8	5
46	R:R:F74	R:R:S295	25.4371	6.61	Yes	No	0	7	9
47	R:R:D71	R:R:S295	26.0801	4.42	Yes	No	0	9	9
48	R:R:I101	R:R:T77	14.4648	7.6	No	No	0	5	7
49	R:R:F80	R:R:I101	12.6885	6.28	No	No	0	6	5
50	R:R:F80	R:R:F93	10.8983	2.14	No	Yes	0	6	7
51	L:L:?1	R:R:Y175	19.5069	14.67	Yes	Yes	3	0	3
52	R:R:D173	R:R:Y175	11.1435	3.45	No	Yes	0	3	3
53	L:L:?1	R:R:R201	25.525	5.79	Yes	No	0	0	5
54	R:R:F178	R:R:R201	19.0952	4.28	No	No	0	4	5
55	R:R:F178	R:R:L164	17.1986	4.87	No	Yes	0	4	5
56	R:R:F114	R:R:P213	11.384	2.89	No	Yes	0	6	9
57	R:R:P213	R:R:V113	21.9586	3.53	Yes	No	0	9	7
58	R:R:R123	R:R:Y221	48.6308	7.2	Yes	Yes	1	9	8
59	R:R:A120	R:R:Y221	62.6099	4	No	Yes	0	9	8
60	R:R:V246	R:R:Y302	47.3494	5.05	No	Yes	0	8	9
61	R:R:V246	R:R:Y221	40.0777	10.09	No	Yes	0	8	8
62	R:R:A120	R:R:C220	59.6124	1.81	No	Yes	0	9	7
63	R:R:C124	R:R:C220	49.8844	7.28	No	Yes	0	8	7
64	R:R:C124	R:R:L128	46.6232	3.17	No	Yes	0	8	7
65	R:R:K227	R:R:L128	13.498	5.64	No	Yes	0	5	7
66	R:R:H129	R:R:L128	23.5359	1.29	No	Yes	0	6	7
67	R:R:H129	R:R:P130	20.2008	1.53	No	No	0	6	8
68	R:R:P130	R:R:V131	16.8563	1.77	No	No	0	8	5
69	R:R:N135	R:R:V131	13.5026	1.48	No	No	0	4	5
70	R:R:H136	R:R:N135	10.1397	5.1	No	No	0	3	4
71	R:R:F210	R:R:Q258	31.3396	15.23	No	Yes	0	9	8
72	R:R:F210	R:R:F255	51.4617	6.43	No	Yes	0	9	6
73	R:R:F255	R:R:L259	68.3134	2.44	Yes	No	0	6	5
74	R:R:L259	R:R:L263	66.0468	2.77	No	No	0	5	5
75	R:R:L263	R:R:W267	63.7709	7.97	No	No	0	5	3
76	R:R:W267	R:R:Y277	52.2528	8.68	No	No	0	3	3
77	R:R:K276	R:R:Y277	49.9214	15.53	No	No	0	1	3
78	R:R:E270	R:R:K276	47.5807	8.1	No	No	0	2	1
79	R:R:E270	R:R:K269	45.2308	4.05	No	No	0	2	4
80	R:R:F273	R:R:K269	35.896	3.72	Yes	No	0	5	4
81	R:R:F273	R:R:L272	29.0406	9.74	Yes	No	0	5	3
82	R:R:L268	R:R:L272	26.6121	2.77	No	No	0	3	3
83	R:R:L198	R:R:L268	24.165	2.77	No	No	0	4	3
84	R:R:L198	R:R:M197	21.9539	4.24	No	No	0	4	1
85	R:R:F180	R:R:M197	19.4884	4.98	No	No	0	6	1
86	R:R:F163	R:R:F180	14.7886	31.08	No	No	0	5	6
87	L:L:?1	R:R:N179	26.1911	8.18	Yes	No	0	0	3
88	R:R:A181	R:R:N179	24.3177	1.56	No	No	0	5	3
89	R:R:A181	R:R:R190	22.1528	2.77	No	No	0	5	5
90	R:R:P187	R:R:R190	15.6027	12.97	No	No	0	5	5
91	R:R:P187	R:R:T186	13.4009	1.75	No	No	0	5	6
92	R:R:V266	R:R:W267	10.0426	3.68	No	No	0	4	3
93	R:R:F210	R:R:M214	22.7727	2.49	No	No	0	9	6
94	R:R:F251	R:R:M214	22.8282	8.71	No	No	0	6	6
95	R:R:F251	R:R:F255	21.9262	12.86	No	Yes	0	6	6
96	R:R:K227	R:R:K231	10.1397	5.75	No	No	0	5	5
97	R:R:F309	R:R:G306	23.5221	1.51	Yes	No	0	8	8
98	R:R:G306	R:R:V305	19.5717	1.84	No	No	0	8	7
99	R:R:R238	R:R:V305	15.8202	1.31	No	No	0	7	7
100	R:R:F250	R:R:M214	45.4945	4.98	Yes	No	0	9	6
101	R:R:F250	R:R:V113	14.8719	2.62	Yes	No	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:E89	8.68	3	Yes	No	0	4	0	1
L:L:?1	R:R:D106	4.04	3	Yes	No	0	5	0	1
L:L:?1	R:R:F110	2.9	3	Yes	No	0	7	0	1
L:L:?1	R:R:P170	2.94	3	Yes	No	0	3	0	1
L:L:?1	R:R:Y175	14.67	3	Yes	Yes	0	3	0	1
L:L:?1	R:R:T177	7.03	3	Yes	No	0	3	0	1
L:L:?1	R:R:N179	8.18	3	Yes	No	0	3	0	1
L:L:?1	R:R:R201	5.79	3	Yes	No	0	5	0	1
L:L:?1	R:R:R205	9.41	3	Yes	No	0	5	0	1
R:R:D106	R:R:F110	14.33	3	No	No	5	7	1	1
R:R:D106	R:R:T157	8.67	3	No	No	5	7	1	2
R:R:F110	R:R:L156	8.53	3	No	No	7	5	1	2
R:R:I169	R:R:P170	3.39	0	No	No	1	3	2	1
R:R:I169	R:R:Y175	12.09	0	No	Yes	1	3	2	1
R:R:D173	R:R:Y175	3.45	0	No	Yes	3	3	2	1
R:R:T177	R:R:Y175	8.74	3	No	Yes	3	3	1	1
R:R:F178	R:R:R201	4.28	0	No	No	4	5	2	1
R:R:G202	R:R:R201	3	0	No	No	4	5	2	1
R:R:Q258	R:R:R205	4.67	1	Yes	No	8	5	2	1
R:R:A261	R:R:R205	4.15	0	No	No	5	5	2	1
L:L:?1	R:R:V167	1.78	3	Yes	No	0	1	0	1
R:R:E89	R:R:G88	1.64	0	No	No	4	3	1	2
R:R:T165	R:R:V167	1.59	0	No	No	4	1	2	1
R:R:A181	R:R:N179	1.56	0	No	No	5	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JHJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	273
Number of Links	301
Number of Hubs	35
Number of Links mediated by Hubs	140
Number of Communities	9
Number of Nodes involved in Communities	43
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	67095
Length Of Smallest Path	3
Average Path Length	14.4599
Length of Longest Path	36
Minimum Path Strength	1.315
Average Path Strength	5.47726
Maximum Path Strength	18.03
Minimum Path Correlation	0.7
Average Path Correlation	0.93057
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	46.8262
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.2079
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	18C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	18C
Name	N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE
Synonyms	C18-CERAMIDE; N-STEAROYL-D-ERYTHRO-SPHINGOSINE; (2S,3R,4E)-2-STEAROYLAMINOOCTADEC-4-ENE-1,3-DIOL; (2S,3R,4E)-2-STEAROYLAMINO-1,3-OCTADEC-4-ENEDIOL
Identifier
Formula	C36 H71 N O3
Molecular Weight	565.954
SMILES
PubChem	5283565
Formal Charge	0
Total Atoms	111
Total Chiral Atoms	2
Total Bonds	110
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>9JHJ_nogp_Chain_R V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	TC-FPR 43	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	TC-FPR 43	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188
	8ZBW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Quin-C1	-	Gi2/β1/γ2	2.58	2025-09-10	doi.org/10.1038/s41401-025-01525-7
	8ZBW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Quin-C1	-		2.58	2025-09-10	doi.org/10.1038/s41401-025-01525-7

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