psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	7.38	Yes	No	1	0	5
2	L:L:?1	R:R:L109	6.28	Yes	No	0	0	8
3	L:L:?1	R:R:F110	16.57	Yes	Yes	1	0	7
4	L:L:?1	R:R:R201	13.22	Yes	Yes	1	0	5
5	L:L:?1	R:R:R205	24.23	Yes	Yes	1	0	5
6	L:L:?1	R:R:W254	5.16	Yes	Yes	1	0	9
7	L:L:?1	R:R:F257	6.63	Yes	Yes	1	0	7
8	L:L:?1	R:R:Q258	3.62	Yes	Yes	1	0	8
9	L:L:I4	L:L:Y2	3.63	No	Yes	0	0	0
10	L:L:Y2	R:R:L81	14.07	Yes	No	4	0	6
11	L:L:Y2	R:R:V105	3.79	Yes	Yes	4	0	6
12	L:L:Y2	R:R:F292	4.13	Yes	Yes	0	0	7
13	L:L:F3	R:R:V284	9.18	No	No	0	0	5
14	L:L:I4	R:R:T177	3.04	No	Yes	0	0	3
15	L:L:I4	R:R:F178	8.79	No	Yes	0	0	4
16	L:L:I6	R:R:L198	7.14	No	No	0	0	4
17	L:L:I6	R:R:L272	7.14	No	No	0	0	3
18	L:L:L7	R:R:Y175	9.38	No	No	0	0	3
19	L:L:L7	R:R:T177	4.42	No	Yes	0	0	3
20	R:R:I282	R:R:Y22	4.84	No	No	0	2	2
21	R:R:L28	R:R:P29	3.28	No	No	0	5	5
22	R:R:L28	R:R:V32	2.98	No	No	0	5	5
23	R:R:A86	R:R:L30	3.15	No	No	0	4	5
24	R:R:S289	R:R:V32	4.85	No	No	0	5	5
25	R:R:I82	R:R:L33	5.71	No	No	0	7	7
26	R:R:L33	R:R:M85	4.24	No	No	0	7	6
27	R:R:F292	R:R:L33	6.09	Yes	No	0	7	7
28	R:R:L39	R:R:V35	2.98	No	No	0	5	5
29	R:R:C296	R:R:T36	5.07	No	No	0	8	7
30	R:R:F37	R:R:V41	5.24	No	No	0	6	6
31	R:R:F37	R:R:P79	13	No	No	0	6	8
32	R:R:C296	R:R:G40	3.92	No	No	0	8	8
33	R:R:T75	R:R:V41	4.76	No	No	0	7	6
34	R:R:G43	R:R:L42	3.42	No	No	0	8	4
35	R:R:D71	R:R:N44	6.73	Yes	Yes	1	9	9
36	R:R:F72	R:R:N44	6.04	No	Yes	0	7	9
37	R:R:N44	R:R:P299	6.52	Yes	No	1	9	9
38	R:R:L313	R:R:L46	6.92	No	No	0	6	6
39	R:R:A68	R:R:V47	3.39	No	Yes	0	8	9
40	R:R:V303	R:R:V47	11.22	No	Yes	3	7	9
41	R:R:F304	R:R:V47	3.93	No	Yes	3	7	9
42	R:R:F309	R:R:V47	9.18	Yes	Yes	3	8	9
43	R:R:A68	R:R:I48	3.25	No	No	0	8	7
44	R:R:I48	R:R:L69	4.28	No	No	0	7	6
45	R:R:R54	R:R:W49	3	No	No	5	4	4
46	R:R:S316	R:R:W49	8.65	Yes	No	5	5	4
47	R:R:M55	R:R:V50	3.04	No	No	0	5	7
48	R:R:F309	R:R:V50	9.18	Yes	No	0	8	7
49	R:R:L313	R:R:V50	2.98	No	No	0	6	7
50	R:R:G52	R:R:R57	3	No	No	0	4	6
51	R:R:R54	R:R:S316	5.27	No	Yes	5	4	5
52	R:R:M55	R:R:R312	7.44	No	No	0	5	5
53	R:R:T56	R:R:T58	3.14	No	No	0	6	7
54	R:R:I62	R:R:R57	5.01	Yes	No	0	7	6
55	R:R:T58	R:R:T60	4.71	No	No	0	7	7
56	R:R:T58	R:R:T61	7.85	No	No	0	7	7
57	R:R:R137	R:R:V59	13.08	No	No	0	7	6
58	R:R:A142	R:R:V59	5.09	No	No	0	7	6
59	R:R:T60	R:R:Y64	8.74	No	No	0	7	8
60	R:R:I62	R:R:V139	3.07	Yes	No	0	7	3
61	R:R:I62	R:R:M143	5.83	Yes	No	0	7	4
62	R:R:C63	R:R:I119	4.91	No	No	0	7	9
63	R:R:R123	R:R:Y64	5.14	Yes	No	0	9	8
64	R:R:V303	R:R:Y64	7.57	No	No	0	7	8
65	R:R:L115	R:R:N66	4.12	No	No	0	8	9
66	R:R:I146	R:R:N66	9.91	No	No	0	7	9
67	R:R:D71	R:R:L67	4.07	Yes	No	1	9	9
68	R:R:L67	R:R:S112	3	No	No	1	9	9
69	R:R:L67	R:R:Y302	3.52	No	Yes	1	9	9
70	R:R:D71	R:R:S112	5.89	Yes	No	1	9	9
71	R:R:D71	R:R:P299	4.83	Yes	No	1	9	9
72	R:R:N108	R:R:S73	7.45	No	No	0	8	7
73	R:R:F74	R:R:V105	7.87	Yes	Yes	0	7	6
74	R:R:F74	R:R:N108	6.04	Yes	No	0	7	8
75	R:R:F74	R:R:L109	9.74	Yes	No	0	7	8
76	R:R:F292	R:R:F74	12.86	Yes	Yes	0	7	7
77	R:R:F74	R:R:S295	3.96	Yes	No	0	7	9
78	R:R:I101	R:R:T77	7.6	No	No	0	5	7
79	R:R:T77	R:R:V104	7.93	No	No	0	7	5
80	R:R:T77	R:R:V105	3.17	No	Yes	0	7	6
81	R:R:F292	R:R:L78	3.65	Yes	No	0	7	8
82	R:R:F80	R:R:W91	6.01	No	Yes	2	6	9
83	R:R:F80	R:R:F93	4.29	No	Yes	2	6	7
84	R:R:F80	R:R:I101	17.58	No	No	2	6	5
85	R:R:L81	R:R:V105	4.47	No	Yes	4	6	6
86	R:R:E89	R:R:S84	4.31	No	No	0	4	5
87	R:R:S84	R:R:W91	4.94	No	Yes	0	5	9
88	R:R:E89	R:R:M85	4.06	No	No	0	4	6
89	R:R:K90	R:R:M87	5.76	No	No	0	4	4
90	R:R:M87	R:R:P92	5.03	No	No	0	4	3
91	R:R:D173	R:R:K90	15.21	No	No	0	3	4
92	R:R:K90	R:R:Y175	9.55	No	No	0	4	3
93	R:R:F93	R:R:W91	7.02	Yes	Yes	2	7	9
94	R:R:C98	R:R:W91	11.75	No	Yes	2	9	9
95	R:R:I101	R:R:W91	4.7	No	Yes	2	5	9
96	R:R:C176	R:R:W91	7.84	No	Yes	2	9	9
97	R:R:F93	R:R:P92	4.33	Yes	No	0	7	3
98	R:R:F93	R:R:L97	7.31	Yes	No	0	7	7
99	R:R:K99	R:R:W95	12.76	No	Yes	0	7	4
100	R:R:T165	R:R:W95	7.28	No	Yes	0	4	4
101	R:R:T166	R:R:W95	6.06	No	Yes	0	5	4
102	R:R:C98	R:R:H102	5.9	No	No	0	9	6
103	R:R:C176	R:R:C98	7.28	No	No	2	9	9
104	R:R:H102	R:R:L164	5.14	No	No	0	6	5
105	R:R:I103	R:R:V160	3.07	No	No	0	5	4
106	R:R:F161	R:R:I103	15.07	Yes	No	0	4	5
107	R:R:N108	R:R:V104	4.43	No	No	0	8	5
108	R:R:D106	R:R:F110	8.36	No	Yes	1	5	7
109	R:R:D106	R:R:T157	11.56	No	Yes	1	5	7
110	R:R:I107	R:R:T157	4.56	Yes	Yes	1	5	7
111	R:R:F161	R:R:I107	3.77	Yes	Yes	1	4	5
112	R:R:F110	R:R:F114	7.5	Yes	Yes	1	7	6
113	R:R:F110	R:R:L156	4.87	Yes	No	0	7	5
114	R:R:P213	R:R:V113	3.53	No	No	0	9	7
115	R:R:V113	R:R:W254	3.68	No	Yes	0	7	9
116	R:R:F114	R:R:P149	5.78	Yes	No	0	6	7
117	R:R:F114	R:R:L152	8.53	Yes	No	0	6	4
118	R:R:G117	R:R:I116	3.53	No	Yes	0	7	8
119	R:R:F250	R:R:I116	7.54	No	Yes	1	9	8
120	R:R:I116	R:R:N298	7.08	Yes	No	1	8	9
121	R:R:I116	R:R:Y302	9.67	Yes	Yes	1	8	9
122	R:R:F118	R:R:V145	5.24	No	No	0	7	5
123	R:R:F118	R:R:I146	5.02	No	No	0	7	7
124	R:R:I119	R:R:R123	7.52	No	Yes	1	9	9
125	R:R:I119	R:R:Y302	3.63	No	Yes	1	9	9
126	R:R:A120	R:R:C220	3.61	No	No	0	9	7
127	R:R:A120	R:R:Y221	4	No	Yes	0	9	8
128	R:R:C220	R:R:L121	3.17	No	No	0	7	7
129	R:R:C126	R:R:D122	3.11	No	No	6	8	8
130	R:R:D122	R:R:R137	7.15	No	No	6	8	7
131	R:R:R123	R:R:Y221	8.23	Yes	Yes	1	9	8
132	R:R:R123	R:R:Y302	6.17	Yes	Yes	1	9	9
133	R:R:C124	R:R:L128	3.17	No	No	7	8	7
134	R:R:C124	R:R:C220	7.28	No	No	0	8	7
135	R:R:C124	R:R:L223	3.17	No	No	7	8	3
136	R:R:A133	R:R:C126	3.61	No	No	0	5	8
137	R:R:C126	R:R:R137	5.57	No	No	6	8	7
138	R:R:I224	R:R:V127	13.83	No	No	0	8	8
139	R:R:K227	R:R:V127	4.55	Yes	No	0	5	8
140	R:R:L128	R:R:L223	8.3	No	No	7	7	3
141	R:R:H129	R:R:V131	4.15	No	No	0	6	5
142	R:R:H129	R:R:W132	10.58	No	No	0	6	5
143	R:R:K227	R:R:P130	3.35	Yes	No	0	5	8
144	R:R:N135	R:R:V131	4.43	No	No	0	4	5
145	R:R:H136	R:R:W132	19.04	No	No	0	3	5
146	R:R:N135	R:R:Q134	3.96	No	No	0	4	5
147	R:R:S140	R:R:T138	4.8	No	No	0	4	6
148	R:R:K144	R:R:S140	3.06	No	No	0	1	4
149	R:R:L141	R:R:V145	2.98	No	No	0	3	5
150	R:R:G148	R:R:P149	4.06	No	No	0	3	7
151	R:R:G148	R:R:I151	3.53	No	No	0	3	3
152	R:R:I204	R:R:L156	4.28	No	No	0	4	5
153	R:R:T157	R:R:V160	4.76	Yes	No	0	7	4
154	R:R:F161	R:R:T157	7.78	Yes	Yes	1	4	7
155	R:R:F161	R:R:L158	3.65	Yes	No	0	4	4
156	R:R:R201	R:R:V160	3.92	Yes	No	0	5	4
157	R:R:F163	R:R:L162	3.65	Yes	No	0	5	5
158	R:R:F163	R:R:F180	5.36	Yes	No	0	5	6
159	R:R:F163	R:R:W183	14.03	Yes	No	0	5	4
160	R:R:F163	R:R:M197	11.2	Yes	No	0	5	1
161	R:R:F178	R:R:L164	7.31	Yes	No	0	4	5
162	R:R:N179	R:R:T165	4.39	Yes	No	0	3	4
163	R:R:C176	R:R:T166	5.07	No	No	0	9	5
164	R:R:T177	R:R:V167	3.17	Yes	No	0	3	1
165	R:R:N179	R:R:V167	4.43	Yes	No	0	3	1
166	R:R:T168	R:R:T174	3.14	No	No	0	2	5
167	R:R:I169	R:R:P170	3.39	No	No	0	1	3
168	R:R:I169	R:R:N171	7.08	No	No	0	1	4
169	R:R:D173	R:R:I169	5.6	No	No	0	3	1
170	R:R:F178	R:R:F180	4.29	Yes	No	0	4	6
171	R:R:F178	R:R:M197	4.98	Yes	No	0	4	1
172	R:R:F178	R:R:R201	4.28	Yes	Yes	0	4	5
173	R:R:A181	R:R:N179	4.69	No	Yes	0	5	3
174	R:R:A194	R:R:F180	8.32	No	No	0	3	6
175	R:R:S182	R:R:W183	3.71	No	No	0	7	4
176	R:R:E189	R:R:G184	4.91	No	No	0	3	3
177	R:R:E189	R:R:G185	3.27	No	No	0	3	3
178	R:R:P187	R:R:T186	3.5	No	No	0	5	6
179	R:R:E188	R:R:T186	8.47	No	No	0	3	6
180	R:R:E189	R:R:T186	9.88	No	No	0	3	6
181	R:R:E188	R:R:K192	5.4	No	No	0	3	5
182	R:R:I195	R:R:L191	4.28	Yes	No	0	1	1
183	R:R:F273	R:R:L191	6.09	No	No	0	5	1
184	R:R:I195	R:R:L268	4.28	Yes	No	0	1	3
185	R:R:I195	R:R:K269	4.36	Yes	No	0	1	4
186	R:R:T196	R:R:T199	3.14	No	No	0	1	3
187	R:R:L198	R:R:L268	4.15	No	No	0	4	3
188	R:R:R201	R:R:R205	3.2	Yes	Yes	1	5	5
189	R:R:G202	R:R:R205	3	No	Yes	0	4	5
190	R:R:G202	R:R:T265	3.64	No	No	0	4	4
191	R:R:Q258	R:R:R205	7.01	Yes	Yes	1	8	5
192	R:R:A261	R:R:R205	5.53	No	Yes	0	5	5
193	R:R:F206	R:R:F210	5.36	No	Yes	0	6	9
194	R:R:F206	R:R:L211	8.53	No	No	0	6	4
195	R:R:F206	R:R:L262	12.18	No	No	0	6	5
196	R:R:I208	R:R:V207	4.61	No	No	0	5	4
197	R:R:F210	R:R:M214	6.22	Yes	No	0	9	6
198	R:R:F210	R:R:F255	6.43	Yes	Yes	0	9	6
199	R:R:F210	R:R:Q258	17.57	Yes	Yes	0	9	8
200	R:R:L212	R:R:P213	4.93	No	No	0	5	9
201	R:R:I216	R:R:L212	4.28	No	No	0	6	5
202	R:R:F251	R:R:M214	4.98	No	No	0	6	6
203	R:R:V217	R:R:Y221	3.79	No	Yes	0	8	8
204	R:R:L243	R:R:Y221	10.55	No	Yes	0	8	8
205	R:R:V247	R:R:Y221	3.79	No	Yes	0	8	8
206	R:R:Y221	R:R:Y302	5.96	Yes	Yes	1	8	9
207	R:R:K227	R:R:K231	5.75	Yes	No	0	5	5
208	R:R:I228	R:R:M233	5.83	No	No	0	8	3
209	R:R:I228	R:R:I234	4.42	No	No	0	8	4
210	R:R:K230	R:R:K231	5.75	No	No	0	4	5
211	R:R:R238	R:R:V242	3.92	Yes	No	0	7	8
212	R:R:R238	R:R:R310	5.33	Yes	No	0	7	8
213	R:R:L301	R:R:V246	5.96	No	No	0	8	8
214	R:R:V246	R:R:Y302	3.79	No	Yes	0	8	9
215	R:R:L297	R:R:S249	4.5	No	No	0	6	7
216	R:R:F250	R:R:W254	14.03	No	Yes	1	9	9
217	R:R:F250	R:R:N294	4.83	No	Yes	1	9	9
218	R:R:F251	R:R:F255	13.93	No	Yes	0	6	6
219	R:R:C253	R:R:W254	5.22	No	Yes	1	8	9
220	R:R:C253	R:R:L290	4.76	No	No	0	8	8
221	R:R:C253	R:R:N294	11.02	No	Yes	1	8	9
222	R:R:F257	R:R:W254	3.01	Yes	Yes	1	7	9
223	R:R:Q258	R:R:W254	5.48	Yes	Yes	1	8	9
224	R:R:A291	R:R:W254	5.19	No	Yes	0	8	9
225	R:R:N294	R:R:W254	7.91	Yes	Yes	1	9	9
226	R:R:F255	R:R:L259	3.65	Yes	No	0	6	5
227	R:R:F257	R:R:T287	9.08	Yes	No	0	7	7
228	R:R:F257	R:R:S288	5.28	Yes	No	0	7	6
229	R:R:T287	R:R:V260	3.17	No	No	0	7	5
230	R:R:L262	R:R:T265	4.42	No	No	0	5	4
231	R:R:L262	R:R:V266	2.98	No	No	0	5	4
232	R:R:L263	R:R:W267	13.67	No	Yes	0	5	3
233	R:R:V266	R:R:W267	7.36	No	Yes	0	4	3
234	R:R:E270	R:R:W267	5.45	No	Yes	0	2	3
235	R:R:W267	R:R:Y277	13.5	Yes	No	8	3	3
236	R:R:I280	R:R:W267	4.7	Yes	Yes	8	4	3
237	R:R:L268	R:R:L272	5.54	No	No	0	3	3
238	R:R:F273	R:R:K269	9.93	No	No	0	5	4
239	R:R:I280	R:R:M271	5.83	Yes	No	0	4	1
240	R:R:F273	R:R:Y274	3.09	No	No	0	5	5
241	R:R:I280	R:R:Y277	3.63	Yes	No	8	4	3
242	R:R:F293	R:R:L297	7.31	No	No	0	5	6
243	R:R:L297	R:R:N294	4.12	No	Yes	0	6	9
244	R:R:N294	R:R:N298	9.54	Yes	No	1	9	9
245	R:R:N298	R:R:Y302	3.49	No	Yes	1	9	9
246	R:R:F304	R:R:M300	6.22	No	No	0	7	7
247	R:R:F309	R:R:V303	7.87	Yes	No	3	8	7
248	R:R:F304	R:R:F309	7.5	No	Yes	3	7	8
249	R:R:D308	R:R:Q307	5.22	No	No	0	6	5
250	R:R:Q307	R:R:R310	4.67	No	No	0	5	8
251	R:R:L313	R:R:S316	4.5	No	Yes	0	6	5
252	R:R:L78	R:R:T36	2.95	No	No	0	8	7
253	R:R:I204	R:R:I208	2.94	No	No	0	4	5
254	R:R:I279	R:R:I280	2.94	No	Yes	0	3	4
255	L:L:N5	R:R:T177	2.92	No	Yes	0	0	3
256	R:R:N44	R:R:T75	2.92	Yes	No	0	9	7
257	R:R:F255	R:R:P256	2.89	Yes	No	0	6	9
258	R:R:P187	R:R:R190	2.88	No	No	0	5	5
259	R:R:P239	R:R:R238	2.88	No	Yes	0	7	7
260	R:R:I107	R:R:L154	2.85	Yes	No	0	5	4
261	R:R:I234	R:R:L240	2.85	No	No	0	4	5
262	R:R:I279	R:R:L283	2.85	No	No	0	3	6
263	R:R:L198	R:R:M197	2.83	No	No	0	4	1
264	R:R:K227	R:R:L128	2.82	Yes	No	0	5	7
265	R:R:M85	R:R:N285	2.8	No	No	0	6	4
266	R:R:C63	R:R:F118	2.79	No	No	0	7	7
267	R:R:D308	R:R:E311	2.6	No	No	0	6	4
268	R:R:A70	R:R:W150	2.59	No	No	0	8	9
269	R:R:E311	R:R:H315	2.46	No	No	0	4	4
270	R:R:L65	R:R:R57	2.43	No	No	0	5	6
271	R:R:N179	R:R:R190	2.41	Yes	No	0	3	5
272	R:R:K276	R:R:Y274	2.39	No	No	0	1	5
273	R:R:K276	R:R:Y277	2.39	No	No	0	1	3
274	R:R:I107	R:R:W150	2.35	Yes	No	0	5	9
275	R:R:I125	R:R:W132	2.35	No	No	0	5	5
276	R:R:I146	R:R:W150	2.35	No	No	0	7	9
277	L:L:F3	R:R:F257	2.14	No	Yes	0	0	7
278	R:R:F96	R:R:W95	2	No	Yes	0	1	4
279	R:R:A20	R:R:G21	1.95	No	No	0	4	4
280	R:R:A51	R:R:G52	1.95	No	No	0	7	4
281	R:R:G21	R:R:S19	1.86	No	No	0	4	4
282	R:R:G306	R:R:V305	1.84	No	No	0	8	7
283	R:R:P286	R:R:S289	1.78	No	No	0	6	5
284	R:R:G34	R:R:I82	1.76	No	No	0	5	7
285	R:R:G209	R:R:I208	1.76	No	No	0	6	5
286	R:R:G264	R:R:I280	1.76	No	Yes	0	4	4
287	R:R:G43	R:R:L46	1.71	No	No	0	8	6
288	R:R:A51	R:R:T61	1.68	No	No	0	7	7
289	R:R:L25	R:R:P286	1.64	No	No	0	3	6
290	R:R:E89	R:R:G88	1.64	No	No	0	4	3
291	R:R:L158	R:R:P159	1.64	No	No	0	4	8
292	R:R:L283	R:R:P286	1.64	No	No	0	6	6
293	R:R:G306	R:R:Q307	1.64	No	No	0	8	5
294	R:R:S236	R:R:S237	1.63	No	No	0	6	4
295	R:R:A142	R:R:I62	1.62	No	Yes	0	7	7
296	R:R:A218	R:R:M214	1.61	No	No	0	5	6
297	R:R:V31	R:R:V32	1.6	No	No	0	6	5
298	R:R:V242	R:R:V246	1.6	No	No	0	8	8
299	R:R:T36	R:R:V35	1.59	No	No	0	7	5
300	R:R:C296	R:R:L39	1.59	No	No	0	8	5
301	R:R:T196	R:R:V193	1.59	No	No	0	1	4
302	R:R:A225	R:R:L240	1.58	No	No	0	5	5
303	R:R:A225	R:R:L243	1.58	No	No	0	5	8
304	R:R:A245	R:R:L301	1.58	No	No	0	6	8
305	R:R:I216	R:R:S215	1.55	No	No	0	6	3
306	R:R:I151	R:R:V147	1.54	No	No	0	3	4
307	R:R:I203	R:R:V207	1.54	No	No	0	4	4
308	R:R:H129	R:R:P130	1.53	No	No	0	6	8
309	R:R:I27	R:R:T23	1.52	No	No	0	6	2
310	R:R:I195	R:R:T199	1.52	Yes	No	0	1	3
311	R:R:F53	R:R:G52	1.51	No	No	0	4	4
312	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
313	R:R:F110	R:R:G111	1.51	Yes	No	1	7	7
314	R:R:F114	R:R:G111	1.51	Yes	No	1	6	7
315	R:R:L317	R:R:S316	1.5	No	Yes	0	5	5
316	R:R:L100	R:R:V104	1.49	No	No	0	5	5
317	R:R:L141	R:R:T138	1.47	No	No	0	3	6
318	R:R:I282	R:R:L25	1.43	No	No	0	2	3
319	R:R:I82	R:R:L30	1.43	No	No	0	7	5
320	R:R:I219	R:R:L223	1.43	No	No	0	3	3
321	R:R:A153	R:R:F110	1.39	No	Yes	1	8	7
322	R:R:A153	R:R:F114	1.39	No	Yes	1	8	6
323	R:R:D281	R:R:M271	1.39	No	No	0	4	1
324	R:R:H229	R:R:I234	1.33	No	No	0	3	4
325	R:R:H315	R:R:I314	1.33	No	No	0	4	3
326	R:R:R238	R:R:S236	1.32	Yes	No	0	7	6
327	R:R:F37	R:R:V38	1.31	No	No	0	6	5
328	R:R:F93	R:R:V83	1.31	Yes	No	0	7	5
329	R:R:R241	R:R:V242	1.31	No	No	0	5	8
330	R:R:S19	R:R:Y22	1.27	No	No	0	4	2
331	R:R:F251	R:R:I252	1.26	No	No	0	6	6
332	R:R:I27	R:R:R26	1.25	No	No	0	6	4
333	R:R:T174	R:R:W91	1.21	No	Yes	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.3862	8	1	0
2	L:L:Y2	6.405	4	4	0
3	R:R:N44	5.5525	4	1	9
4	R:R:V47	6.93	4	3	9
5	R:R:I62	3.8825	4	0	7
6	R:R:D71	5.38	4	1	9
7	R:R:F74	8.094	5	0	7
8	R:R:W91	6.21	7	2	9
9	R:R:F93	4.295	6	2	7
10	R:R:W95	7.025	4	0	4
11	R:R:V105	4.825	4	4	6
12	R:R:I107	3.3825	4	1	5
13	R:R:F110	6.7	6	1	7
14	R:R:F114	4.942	5	1	6
15	R:R:I116	6.955	4	1	8
16	R:R:R123	6.765	4	1	9
17	R:R:T157	7.165	4	1	7
18	R:R:F161	7.5675	4	1	4
19	R:R:F163	8.56	4	0	5
20	R:R:T177	3.3875	4	0	3
21	R:R:F178	5.93	5	0	4
22	R:R:N179	3.98	4	0	3
23	R:R:I195	3.61	4	0	1
24	R:R:R201	6.155	4	1	5
25	R:R:R205	8.594	5	1	5
26	R:R:F210	8.895	4	0	9
27	R:R:Y221	6.05333	6	1	8
28	R:R:K227	4.1175	4	0	5
29	R:R:R238	3.3625	4	0	7
30	R:R:W254	6.21	8	1	9
31	R:R:F255	6.725	4	0	6
32	R:R:F257	5.228	5	1	7
33	R:R:Q258	8.42	4	1	8
34	R:R:W267	8.936	5	8	3
35	R:R:I280	3.772	5	8	4
36	R:R:F292	6.6825	4	0	7
37	R:R:N294	7.484	5	1	9
38	R:R:Y302	5.17571	7	1	9
39	R:R:F309	8.4325	4	3	8
40	R:R:S316	4.98	4	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R201	59.5361	13.22	Yes	Yes	1	0	5
2	R:R:F178	R:R:R201	70.7462	4.28	Yes	Yes	0	4	5
3	L:L:I4	R:R:F178	33.6494	8.79	No	Yes	0	0	4
4	L:L:?1	R:R:L109	45.1671	6.28	Yes	No	0	0	8
5	R:R:F74	R:R:L109	44.2444	9.74	Yes	No	0	7	8
6	R:R:F74	R:R:V105	19.1587	7.87	Yes	Yes	0	7	6
7	R:R:F292	R:R:F74	21.302	12.86	Yes	Yes	0	7	7
8	L:L:I4	R:R:T177	30.4168	3.04	No	Yes	0	0	3
9	R:R:F178	R:R:M197	23.3332	4.98	Yes	No	0	4	1
10	R:R:L198	R:R:M197	17.89	2.83	No	No	0	4	1
11	R:R:L198	R:R:L268	14.6349	4.15	No	No	0	4	3
12	L:L:L7	R:R:T177	10.1496	4.42	No	Yes	0	0	3
13	R:R:G202	R:R:R205	15.9453	3	No	Yes	0	4	5
14	R:R:G202	R:R:T265	14.0679	3.64	No	No	0	4	4
15	R:R:L262	R:R:T265	12.2609	4.42	No	No	0	5	4
16	R:R:L262	R:R:V266	37.4652	2.98	No	No	0	5	4
17	R:R:V266	R:R:W267	36.0587	7.36	No	Yes	0	4	3
18	R:R:I280	R:R:W267	27.5847	4.7	Yes	Yes	8	4	3
19	R:R:I279	R:R:I280	23.1026	2.94	No	Yes	0	3	4
20	R:R:I279	R:R:L283	21.4846	2.85	No	No	0	3	6
21	R:R:L283	R:R:P286	19.8603	1.64	No	No	0	6	6
22	L:L:?1	R:R:Q258	12.0943	3.62	Yes	Yes	1	0	8
23	R:R:F210	R:R:Q258	43.5011	17.57	Yes	Yes	0	9	8
24	R:R:F206	R:R:F210	29.5005	5.36	No	Yes	0	6	9
25	R:R:F206	R:R:L262	26.7132	12.18	No	No	0	6	5
26	R:R:F292	R:R:L33	12.6518	6.09	Yes	No	0	7	7
27	R:R:F292	R:R:L78	10.3803	3.65	Yes	No	0	7	8
28	L:L:?1	R:R:W254	100	5.16	Yes	Yes	1	0	9
29	R:R:F250	R:R:W254	67.2156	14.03	No	Yes	1	9	9
30	R:R:F250	R:R:I116	66.9625	7.54	No	Yes	1	9	8
31	R:R:I116	R:R:Y302	66.3057	9.67	Yes	Yes	1	8	9
32	R:R:L67	R:R:Y302	18.1175	3.52	No	Yes	1	9	9
33	R:R:D71	R:R:L67	14.8752	4.07	Yes	No	1	9	9
34	R:R:D71	R:R:N44	11.6138	6.73	Yes	Yes	1	9	9
35	R:R:N294	R:R:W254	68.4138	7.91	Yes	Yes	1	9	9
36	R:R:N294	R:R:N298	68.0069	9.54	Yes	No	1	9	9
37	R:R:N298	R:R:Y302	67.6641	3.49	No	Yes	1	9	9
38	R:R:R123	R:R:Y302	56.3003	6.17	Yes	Yes	1	9	9
39	R:R:R123	R:R:Y64	61.5224	5.14	Yes	No	0	9	8
40	R:R:V303	R:R:Y64	33.7039	7.57	No	No	0	7	8
41	R:R:F309	R:R:V303	22.5131	7.87	Yes	No	3	8	7
42	R:R:F309	R:R:V50	17.9348	9.18	Yes	No	0	8	7
43	R:R:L313	R:R:V50	13.1195	2.98	No	No	0	6	7
44	R:R:T60	R:R:Y64	28.9367	8.74	No	No	0	7	8
45	R:R:T58	R:R:T60	27.3764	4.71	No	No	0	7	7
46	R:R:T58	R:R:T61	24.2367	7.85	No	No	0	7	7
47	R:R:A51	R:R:T61	22.6572	1.68	No	No	0	7	7
48	R:R:A51	R:R:G52	21.0713	1.95	No	No	0	7	4
49	R:R:G52	R:R:R57	17.8804	3	No	No	0	4	6
50	R:R:I62	R:R:R57	14.6638	5.01	Yes	No	0	7	6
51	R:R:C63	R:R:I119	10.8609	4.91	No	No	0	7	9
52	R:R:I107	R:R:T157	10.0311	4.56	Yes	Yes	1	5	7
53	R:R:I107	R:R:W150	10.9153	2.35	Yes	No	0	5	9
54	R:R:I146	R:R:W150	10.2746	2.35	No	No	0	7	9
55	R:R:T77	R:R:V105	16.8167	3.17	No	Yes	0	7	6
56	R:R:I101	R:R:T77	15.7947	7.6	No	No	0	5	7
57	R:R:F178	R:R:L164	20.0077	7.31	Yes	No	0	4	5
58	R:R:H102	R:R:L164	18.787	5.14	No	No	0	6	5
59	R:R:C98	R:R:H102	17.7875	5.9	No	No	0	9	6
60	R:R:C98	R:R:W91	11.0979	11.75	No	Yes	2	9	9
61	R:R:F93	R:R:W91	11.3542	7.02	Yes	Yes	2	7	9
62	R:R:T177	R:R:V167	18.755	3.17	Yes	No	0	3	1
63	R:R:N179	R:R:V167	17.5376	4.43	Yes	No	0	3	1
64	L:L:?1	R:R:F110	20.0365	16.57	Yes	Yes	1	0	7
65	R:R:Y221	R:R:Y302	43.437	5.96	Yes	Yes	1	8	9
66	R:R:A120	R:R:Y221	33.5725	4	No	Yes	0	9	8
67	R:R:A120	R:R:C220	31.9546	3.61	No	No	0	9	7
68	R:R:C124	R:R:C220	28.6996	7.28	No	No	0	8	7
69	R:R:C124	R:R:L128	23.6792	3.17	No	No	7	8	7
70	R:R:K227	R:R:L128	22.103	2.82	Yes	No	0	5	7
71	R:R:K227	R:R:P130	13.7283	3.35	Yes	No	0	5	8
72	R:R:H129	R:R:P130	12.0399	1.53	No	No	0	6	8
73	R:R:N179	R:R:R190	10.6782	2.41	Yes	No	0	3	5
74	R:R:I195	R:R:L268	12.7383	4.28	Yes	No	0	1	3
75	R:R:L243	R:R:Y221	11.9021	10.55	No	Yes	0	8	8
76	R:R:A225	R:R:L243	10.3322	1.58	No	No	0	5	8
77	R:R:V246	R:R:Y302	27.5142	3.79	No	Yes	0	8	9
78	R:R:V242	R:R:V246	22.8366	1.6	No	No	0	8	8
79	R:R:R238	R:R:V242	19.6328	3.92	Yes	No	0	7	8
80	R:R:R238	R:R:R310	13.1484	5.33	Yes	No	0	7	8
81	R:R:Q307	R:R:R310	11.6362	4.67	No	No	0	5	8
82	R:R:R201	R:R:R205	10.3579	3.2	Yes	Yes	1	5	5
83	R:R:Q258	R:R:W254	32.5954	5.48	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	7.38	1	Yes	No	0	5	0	1
L:L:?1	R:R:L109	6.28	1	Yes	No	0	8	0	1
L:L:?1	R:R:F110	16.57	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R201	13.22	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R205	24.23	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W254	5.16	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F257	6.63	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q258	3.62	1	Yes	Yes	0	8	0	1
L:L:Y2	R:R:L81	14.07	4	Yes	No	0	6	0	1
L:L:Y2	R:R:V105	3.79	4	Yes	Yes	0	6	0	1
L:L:Y2	R:R:F292	4.13	4	Yes	Yes	0	7	0	1
L:L:F3	R:R:V284	9.18	0	No	No	0	5	0	1
L:L:I4	R:R:T177	3.04	0	No	Yes	0	3	0	1
L:L:I4	R:R:F178	8.79	0	No	Yes	0	4	0	1
L:L:I6	R:R:L198	7.14	0	No	No	0	4	0	1
L:L:I6	R:R:L272	7.14	0	No	No	0	3	0	1
L:L:L7	R:R:Y175	9.38	0	No	No	0	3	0	1
L:L:L7	R:R:T177	4.42	0	No	Yes	0	3	0	1
R:R:F292	R:R:L33	6.09	0	Yes	No	7	7	1	2
R:R:F74	R:R:V105	7.87	0	Yes	Yes	7	6	2	1
R:R:F74	R:R:L109	9.74	0	Yes	No	7	8	2	1
R:R:F292	R:R:F74	12.86	0	Yes	Yes	7	7	1	2
R:R:T77	R:R:V105	3.17	0	No	Yes	7	6	2	1
R:R:F292	R:R:L78	3.65	0	Yes	No	7	8	1	2
R:R:L81	R:R:V105	4.47	4	No	Yes	6	6	1	1
R:R:K90	R:R:Y175	9.55	0	No	No	4	3	2	1
R:R:D106	R:R:F110	8.36	1	No	Yes	5	7	1	1
R:R:D106	R:R:T157	11.56	1	No	Yes	5	7	1	2
R:R:F110	R:R:F114	7.5	1	Yes	Yes	7	6	1	2
R:R:F110	R:R:L156	4.87	1	Yes	No	7	5	1	2
R:R:V113	R:R:W254	3.68	0	No	Yes	7	9	2	1
R:R:T157	R:R:V160	4.76	1	Yes	No	7	4	2	2
R:R:R201	R:R:V160	3.92	1	Yes	No	5	4	1	2
R:R:F178	R:R:L164	7.31	0	Yes	No	4	5	1	2
R:R:T177	R:R:V167	3.17	0	Yes	No	3	1	1	2
R:R:F178	R:R:F180	4.29	0	Yes	No	4	6	1	2
R:R:F178	R:R:M197	4.98	0	Yes	No	4	1	1	2
R:R:F178	R:R:R201	4.28	0	Yes	Yes	4	5	1	1
R:R:L198	R:R:L268	4.15	0	No	No	4	3	1	2
R:R:R201	R:R:R205	3.2	1	Yes	Yes	5	5	1	1
R:R:G202	R:R:R205	3	0	No	Yes	4	5	2	1
R:R:Q258	R:R:R205	7.01	1	Yes	Yes	8	5	1	1
R:R:A261	R:R:R205	5.53	0	No	Yes	5	5	2	1
R:R:F210	R:R:Q258	17.57	0	Yes	Yes	9	8	2	1
R:R:F250	R:R:W254	14.03	1	No	Yes	9	9	2	1
R:R:F250	R:R:N294	4.83	1	No	Yes	9	9	2	2
R:R:C253	R:R:W254	5.22	1	No	Yes	8	9	2	1
R:R:C253	R:R:N294	11.02	1	No	Yes	8	9	2	2
R:R:F257	R:R:W254	3.01	1	Yes	Yes	7	9	1	1
R:R:Q258	R:R:W254	5.48	1	Yes	Yes	8	9	1	1
R:R:A291	R:R:W254	5.19	0	No	Yes	8	9	2	1
R:R:N294	R:R:W254	7.91	1	Yes	Yes	9	9	2	1
R:R:F257	R:R:T287	9.08	1	Yes	No	7	7	1	2
R:R:F257	R:R:S288	5.28	1	Yes	No	7	6	1	2
R:R:L268	R:R:L272	5.54	0	No	No	3	3	2	1
L:L:N5	R:R:T177	2.92	0	No	Yes	0	3	0	1
R:R:L198	R:R:M197	2.83	0	No	No	4	1	1	2
L:L:F3	R:R:F257	2.14	0	No	Yes	0	7	0	1
R:R:F110	R:R:G111	1.51	1	Yes	No	7	7	1	2
R:R:F114	R:R:G111	1.51	1	Yes	No	6	7	2	2
R:R:A153	R:R:F110	1.39	1	No	Yes	8	7	2	1
R:R:A153	R:R:F114	1.39	1	No	Yes	8	6	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WVW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	292
Number of Links	333
Number of Hubs	40
Number of Links mediated by Hubs	158
Number of Communities	8
Number of Nodes involved in Communities	53
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	74944
Length Of Smallest Path	3
Average Path Length	13.9139
Length of Longest Path	34
Minimum Path Strength	1.385
Average Path Strength	6.17167
Maximum Path Strength	20.4
Minimum Path Correlation	0.7
Average Path Correlation	0.933335
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	49.9127
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.5432
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to nutrient levels • response to nutrient • midbody • dense core granule • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • molecular transducer activity • signaling receptor activity • amyloid-beta binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • RAGE receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • electron transport chain • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • cellular component organization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of phagocytosis • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • neuron apoptotic process • negative regulation of neuron apoptotic process • regulation of neuron apoptotic process • anatomical structure morphogenesis • odontogenesis of dentin-containing tooth • dentinogenesis • anatomical structure formation involved in morphogenesis • odontogenesis • animal organ morphogenesis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of chemotaxis • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • myeloid leukocyte migration • positive regulation of mononuclear cell migration • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • mononuclear cell migration • leukocyte chemotaxis • cell adhesion • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • defense response to other organism • positive regulation of defense response • cellular response to amyloid-beta • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • periplasmic space • tertiary granule membrane • tertiary granule • cytoplasmic vesicle membrane • vesicle membrane • secretory granule membrane • specific granule membrane • specific granule • ficolin-1-rich granule membrane • ficolin-1-rich granule
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FME
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FME
Name	N-Formylmethionine
Synonyms	L-N-Formylmethionine N-formyl-L-methionine Formyl-methionine N-Formylmethionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid
Identifier
Formula	C6 H11 N O3 S
Molecular Weight	177.221
SMILES
PubChem	439750
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>7WVW_nogp_Chain_R S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F L L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	TC-FPR 43	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	TC-FPR 43	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188
	8ZBW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Quin-C1	-	Gi2/β1/γ2	2.58	2025-09-10	doi.org/10.1038/s41401-025-01525-7
	8ZBW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Quin-C1	-		2.58	2025-09-10	doi.org/10.1038/s41401-025-01525-7

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