Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.3862810
2L:L:Y2 6.405440
3R:R:N44 5.5525419
4R:R:V47 6.93439
5R:R:I62 3.8825407
6R:R:D71 5.38419
7R:R:F74 8.094507
8R:R:W91 6.21729
9R:R:F93 4.295627
10R:R:W95 7.025404
11R:R:V105 4.825446
12R:R:I107 3.3825415
13R:R:F110 6.7617
14R:R:F114 4.942516
15R:R:I116 6.955418
16R:R:R123 6.765419
17R:R:T157 7.165417
18R:R:F161 7.5675414
19R:R:F163 8.56405
20R:R:T177 3.3875403
21R:R:F178 5.93504
22R:R:N179 3.98403
23R:R:I195 3.61401
24R:R:R201 6.155415
25R:R:R205 8.594515
26R:R:F210 8.895409
27R:R:Y221 6.05333618
28R:R:K227 4.1175405
29R:R:R238 3.3625407
30R:R:W254 6.21819
31R:R:F255 6.725406
32R:R:F257 5.228517
33R:R:Q258 8.42418
34R:R:W267 8.936583
35R:R:I280 3.772584
36R:R:F292 6.6825407
37R:R:N294 7.484519
38R:R:Y302 5.17571719
39R:R:F309 8.4325438
40R:R:S316 4.98455
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:R201 59.536113.22YesYes105
2R:R:F178 R:R:R201 70.74624.28YesYes045
3L:L:I4 R:R:F178 33.64948.79NoYes004
4L:L:?1 R:R:L109 45.16716.28YesNo008
5R:R:F74 R:R:L109 44.24449.74YesNo078
6R:R:F74 R:R:V105 19.15877.87YesYes076
7R:R:F292 R:R:F74 21.30212.86YesYes077
8L:L:I4 R:R:T177 30.41683.04NoYes003
9R:R:F178 R:R:M197 23.33324.98YesNo041
10R:R:L198 R:R:M197 17.892.83NoNo041
11R:R:L198 R:R:L268 14.63494.15NoNo043
12L:L:L7 R:R:T177 10.14964.42NoYes003
13R:R:G202 R:R:R205 15.94533NoYes045
14R:R:G202 R:R:T265 14.06793.64NoNo044
15R:R:L262 R:R:T265 12.26094.42NoNo054
16R:R:L262 R:R:V266 37.46522.98NoNo054
17R:R:V266 R:R:W267 36.05877.36NoYes043
18R:R:I280 R:R:W267 27.58474.7YesYes843
19R:R:I279 R:R:I280 23.10262.94NoYes034
20R:R:I279 R:R:L283 21.48462.85NoNo036
21R:R:L283 R:R:P286 19.86031.64NoNo066
22L:L:?1 R:R:Q258 12.09433.62YesYes108
23R:R:F210 R:R:Q258 43.501117.57YesYes098
24R:R:F206 R:R:F210 29.50055.36NoYes069
25R:R:F206 R:R:L262 26.713212.18NoNo065
26R:R:F292 R:R:L33 12.65186.09YesNo077
27R:R:F292 R:R:L78 10.38033.65YesNo078
28L:L:?1 R:R:W254 1005.16YesYes109
29R:R:F250 R:R:W254 67.215614.03NoYes199
30R:R:F250 R:R:I116 66.96257.54NoYes198
31R:R:I116 R:R:Y302 66.30579.67YesYes189
32R:R:L67 R:R:Y302 18.11753.52NoYes199
33R:R:D71 R:R:L67 14.87524.07YesNo199
34R:R:D71 R:R:N44 11.61386.73YesYes199
35R:R:N294 R:R:W254 68.41387.91YesYes199
36R:R:N294 R:R:N298 68.00699.54YesNo199
37R:R:N298 R:R:Y302 67.66413.49NoYes199
38R:R:R123 R:R:Y302 56.30036.17YesYes199
39R:R:R123 R:R:Y64 61.52245.14YesNo098
40R:R:V303 R:R:Y64 33.70397.57NoNo078
41R:R:F309 R:R:V303 22.51317.87YesNo387
42R:R:F309 R:R:V50 17.93489.18YesNo087
43R:R:L313 R:R:V50 13.11952.98NoNo067
44R:R:T60 R:R:Y64 28.93678.74NoNo078
45R:R:T58 R:R:T60 27.37644.71NoNo077
46R:R:T58 R:R:T61 24.23677.85NoNo077
47R:R:A51 R:R:T61 22.65721.68NoNo077
48R:R:A51 R:R:G52 21.07131.95NoNo074
49R:R:G52 R:R:R57 17.88043NoNo046
50R:R:I62 R:R:R57 14.66385.01YesNo076
51R:R:C63 R:R:I119 10.86094.91NoNo079
52R:R:I107 R:R:T157 10.03114.56YesYes157
53R:R:I107 R:R:W150 10.91532.35YesNo059
54R:R:I146 R:R:W150 10.27462.35NoNo079
55R:R:T77 R:R:V105 16.81673.17NoYes076
56R:R:I101 R:R:T77 15.79477.6NoNo057
57R:R:F178 R:R:L164 20.00777.31YesNo045
58R:R:H102 R:R:L164 18.7875.14NoNo065
59R:R:C98 R:R:H102 17.78755.9NoNo096
60R:R:C98 R:R:W91 11.097911.75NoYes299
61R:R:F93 R:R:W91 11.35427.02YesYes279
62R:R:T177 R:R:V167 18.7553.17YesNo031
63R:R:N179 R:R:V167 17.53764.43YesNo031
64L:L:?1 R:R:F110 20.036516.57YesYes107
65R:R:Y221 R:R:Y302 43.4375.96YesYes189
66R:R:A120 R:R:Y221 33.57254NoYes098
67R:R:A120 R:R:C220 31.95463.61NoNo097
68R:R:C124 R:R:C220 28.69967.28NoNo087
69R:R:C124 R:R:L128 23.67923.17NoNo787
70R:R:K227 R:R:L128 22.1032.82YesNo057
71R:R:K227 R:R:P130 13.72833.35YesNo058
72R:R:H129 R:R:P130 12.03991.53NoNo068
73R:R:N179 R:R:R190 10.67822.41YesNo035
74R:R:I195 R:R:L268 12.73834.28YesNo013
75R:R:L243 R:R:Y221 11.902110.55NoYes088
76R:R:A225 R:R:L243 10.33221.58NoNo058
77R:R:V246 R:R:Y302 27.51423.79NoYes089
78R:R:V242 R:R:V246 22.83661.6NoNo088
79R:R:R238 R:R:V242 19.63283.92YesNo078
80R:R:R238 R:R:R310 13.14845.33YesNo078
81R:R:Q307 R:R:R310 11.63624.67NoNo058
82R:R:R201 R:R:R205 10.35793.2YesYes155
83R:R:Q258 R:R:W254 32.59545.48YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D106 7.38 1 Yes No 0 5 0 1
L:L:?1 R:R:L109 6.28 1 Yes No 0 8 0 1
L:L:?1 R:R:F110 16.57 1 Yes Yes 0 7 0 1
L:L:?1 R:R:R201 13.22 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R205 24.23 1 Yes Yes 0 5 0 1
L:L:?1 R:R:W254 5.16 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F257 6.63 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Q258 3.62 1 Yes Yes 0 8 0 1
L:L:Y2 R:R:L81 14.07 4 Yes No 0 6 0 1
L:L:Y2 R:R:V105 3.79 4 Yes Yes 0 6 0 1
L:L:Y2 R:R:F292 4.13 4 Yes Yes 0 7 0 1
L:L:F3 R:R:V284 9.18 0 No No 0 5 0 1
L:L:I4 R:R:T177 3.04 0 No Yes 0 3 0 1
L:L:I4 R:R:F178 8.79 0 No Yes 0 4 0 1
L:L:I6 R:R:L198 7.14 0 No No 0 4 0 1
L:L:I6 R:R:L272 7.14 0 No No 0 3 0 1
L:L:L7 R:R:Y175 9.38 0 No No 0 3 0 1
L:L:L7 R:R:T177 4.42 0 No Yes 0 3 0 1
R:R:F292 R:R:L33 6.09 0 Yes No 7 7 1 2
R:R:F74 R:R:V105 7.87 0 Yes Yes 7 6 2 1
R:R:F74 R:R:L109 9.74 0 Yes No 7 8 2 1
R:R:F292 R:R:F74 12.86 0 Yes Yes 7 7 1 2
R:R:T77 R:R:V105 3.17 0 No Yes 7 6 2 1
R:R:F292 R:R:L78 3.65 0 Yes No 7 8 1 2
R:R:L81 R:R:V105 4.47 4 No Yes 6 6 1 1
R:R:K90 R:R:Y175 9.55 0 No No 4 3 2 1
R:R:D106 R:R:F110 8.36 1 No Yes 5 7 1 1
R:R:D106 R:R:T157 11.56 1 No Yes 5 7 1 2
R:R:F110 R:R:F114 7.5 1 Yes Yes 7 6 1 2
R:R:F110 R:R:L156 4.87 1 Yes No 7 5 1 2
R:R:V113 R:R:W254 3.68 0 No Yes 7 9 2 1
R:R:T157 R:R:V160 4.76 1 Yes No 7 4 2 2
R:R:R201 R:R:V160 3.92 1 Yes No 5 4 1 2
R:R:F178 R:R:L164 7.31 0 Yes No 4 5 1 2
R:R:T177 R:R:V167 3.17 0 Yes No 3 1 1 2
R:R:F178 R:R:F180 4.29 0 Yes No 4 6 1 2
R:R:F178 R:R:M197 4.98 0 Yes No 4 1 1 2
R:R:F178 R:R:R201 4.28 0 Yes Yes 4 5 1 1
R:R:L198 R:R:L268 4.15 0 No No 4 3 1 2
R:R:R201 R:R:R205 3.2 1 Yes Yes 5 5 1 1
R:R:G202 R:R:R205 3 0 No Yes 4 5 2 1
R:R:Q258 R:R:R205 7.01 1 Yes Yes 8 5 1 1
R:R:A261 R:R:R205 5.53 0 No Yes 5 5 2 1
R:R:F210 R:R:Q258 17.57 0 Yes Yes 9 8 2 1
R:R:F250 R:R:W254 14.03 1 No Yes 9 9 2 1
R:R:F250 R:R:N294 4.83 1 No Yes 9 9 2 2
R:R:C253 R:R:W254 5.22 1 No Yes 8 9 2 1
R:R:C253 R:R:N294 11.02 1 No Yes 8 9 2 2
R:R:F257 R:R:W254 3.01 1 Yes Yes 7 9 1 1
R:R:Q258 R:R:W254 5.48 1 Yes Yes 8 9 1 1
R:R:A291 R:R:W254 5.19 0 No Yes 8 9 2 1
R:R:N294 R:R:W254 7.91 1 Yes Yes 9 9 2 1
R:R:F257 R:R:T287 9.08 1 Yes No 7 7 1 2
R:R:F257 R:R:S288 5.28 1 Yes No 7 6 1 2
R:R:L268 R:R:L272 5.54 0 No No 3 3 2 1
L:L:N5 R:R:T177 2.92 0 No Yes 0 3 0 1
R:R:L198 R:R:M197 2.83 0 No No 4 1 1 2
L:L:F3 R:R:F257 2.14 0 No Yes 0 7 0 1
R:R:F110 R:R:G111 1.51 1 Yes No 7 7 1 2
R:R:F114 R:R:G111 1.51 1 Yes No 6 7 2 2
R:R:A153 R:R:F110 1.39 1 No Yes 8 7 2 1
R:R:A153 R:R:F114 1.39 1 No Yes 8 6 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7WVW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.98
Number of Linked Nodes 292
Number of Links 333
Number of Hubs 40
Number of Links mediated by Hubs 158
Number of Communities 8
Number of Nodes involved in Communities 53
Number of Links involved in Communities 71
Path Summary
Number Of Nodes in MetaPath 84
Number Of Links MetaPath 83
Number of Shortest Paths 74944
Length Of Smallest Path 3
Average Path Length 13.9139
Length of Longest Path 34
Minimum Path Strength 1.385
Average Path Strength 6.17167
Maximum Path Strength 20.4
Minimum Path Correlation 0.7
Average Path Correlation 0.933331
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 49.9127
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.5432
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeFME
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeFME
NameN-Formylmethionine
Synonyms
  • N-Formylmethionine
  • Formyl-methionine
  • (2S)-2-(formylamino)-4-(methylthio)butanoic acid
  • L-N-Formylmethionine
  • N-formyl-L-methionine
Identifier
FormulaC6 H11 N O3 S
Molecular Weight177.221
SMILES
PubChem439750
Formal Charge0
Total Atoms22
Total Chiral Atoms1
Total Bonds21
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP25090
Sequence
>7WVW_nogp_Chain_R
SAGYTVLRI LPLVVLGVT FVLGVLGNG LVIWVAGFR MTRTVTTIC 
YLNLALADF SFTATLPFL IVSMAMGEK WPFGWFLCK LIHIVVDIN 
LFGSVFLIG FIALDRCIC VLHPVWAQN HRTVSLAMK VIVGPWILA 
LVLTLPVFL FLTTVTIPN GDTYCTFNF ASWGGTPEE RLKVAITML 
TARGIIRFV IGFLLPMSI VAICYGLIA AKIHKKGMI KSSRPLRVL 
TAVVASFFI CWFPFQLVA LLGTVWLKE MLFYGKYKI IDILVNPTS 
SLAFFNSCL NPMLYVFVG QDFRERLIH SL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y63APeptideFormylpeptideFPR2-ALXHomo sapiensC20:0 Ceramide-Gi1/β1/γ23.22025-02-05To be published
8Y63 (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensC20:0 Ceramide-3.22025-02-05To be published
8Y62APeptideFormylpeptideFPR2-ALXHomo sapiensC16:0 Ceramide-Gi1/β1/γ23.22025-02-05To be published
8Y62 (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensC16:0 Ceramide-3.22025-02-05To be published
7WVYAPeptideFormylpeptideFPR2-ALXHomo sapiensAmyloid-β42-Gi2/β1/γ232022-04-1310.1038/s41467-022-29361-x
7WVY (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensAmyloid-β42-32022-04-1310.1038/s41467-022-29361-x
7WVXAPeptideFormylpeptideFPR2-ALXHomo sapiensHumanin-Gi2/β1/γ22.82022-04-1310.1038/s41467-022-29361-x
7WVX (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensHumanin-2.82022-04-1310.1038/s41467-022-29361-x
7WVWAPeptideFormylpeptideFPR2-ALXHomo sapiensfMYFINILTL-Gi2/β1/γ23.12022-04-1310.1038/s41467-022-29361-x
7WVW (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensfMYFINILTL-3.12022-04-1310.1038/s41467-022-29361-x
7WVVAPeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-Gi2/β1/γ22.92022-04-1310.1038/s41467-022-29361-x
7WVV (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-2.92022-04-1310.1038/s41467-022-29361-x
7T6VAPeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-Gi1/β1/γ23.12022-03-3010.1038/s41467-022-28586-0
7T6V (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensfMLFII-3.12022-03-3010.1038/s41467-022-28586-0
7T6UAPeptideFormylpeptideFPR2-ALXHomo sapiensCGEN-855A-Gi1/β1/γ22.92022-03-3010.1038/s41467-022-28586-0
7T6U (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensCGEN-855A-2.92022-03-3010.1038/s41467-022-28586-0
7T6SAPeptideFormylpeptideFPR2-ALXHomo sapiensPubChem 24776341-Gi1/β1/γ232022-03-3010.1038/s41467-022-28586-0
7T6S (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensPubChem 24776341-32022-03-3010.1038/s41467-022-28586-0
6LW5APeptideFormylpeptideFPR2-ALXHomo sapiensWKYMVm--2.82020-03-2510.1038/s41467-020-15009-1
6OMMAPeptideFormylpeptideFPR2-ALXHomo sapiensWKYMVX-Gi1/β1/γ23.172020-02-2610.1038/s41467-020-14728-9
6OMM (No Gprot) APeptideFormylpeptideFPR2-ALXHomo sapiensWKYMVX-3.172020-02-2610.1038/s41467-020-14728-9




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WVW_nogp.zip



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