psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P286	R:R:P29	7.79	No	No	0	6	5
2	R:R:L30	R:R:M85	4.24	No	No	0	5	6
3	R:R:A86	R:R:L30	4.73	No	No	0	4	5
4	R:R:S289	R:R:V32	4.85	No	No	0	5	5
5	R:R:L33	R:R:L78	5.54	Yes	No	0	7	8
6	R:R:I82	R:R:L33	5.71	No	Yes	0	7	7
7	R:R:L33	R:R:S289	7.51	Yes	No	0	7	5
8	R:R:F292	R:R:L33	3.65	Yes	Yes	0	7	7
9	R:R:F293	R:R:T36	3.89	No	No	2	5	7
10	R:R:C296	R:R:T36	10.14	No	No	2	8	7
11	R:R:F37	R:R:V41	3.93	Yes	No	0	6	6
12	R:R:F37	R:R:L78	6.09	Yes	No	0	6	8
13	R:R:F37	R:R:P79	10.11	Yes	No	0	6	8
14	R:R:C296	R:R:L39	6.35	No	No	0	8	5
15	R:R:L39	R:R:M300	5.65	No	No	0	5	7
16	R:R:G40	R:R:T75	3.64	No	No	0	8	7
17	R:R:D71	R:R:N44	16.16	No	Yes	0	9	9
18	R:R:F72	R:R:N44	4.83	No	Yes	0	7	9
19	R:R:N44	R:R:T75	4.39	Yes	No	0	9	7
20	R:R:N44	R:R:P299	6.52	Yes	No	0	9	9
21	R:R:F304	R:R:L46	3.65	No	No	0	7	6
22	R:R:L313	R:R:L46	6.92	No	No	0	6	6
23	R:R:P299	R:R:V47	5.3	No	No	0	9	9
24	R:R:V303	R:R:V47	4.81	No	No	1	7	9
25	R:R:F309	R:R:V47	5.24	Yes	No	1	8	9
26	R:R:A68	R:R:I48	4.87	No	No	0	8	7
27	R:R:V50	R:R:W49	3.68	No	No	0	7	4
28	R:R:R54	R:R:W49	11	Yes	No	0	4	4
29	R:R:L317	R:R:W49	5.69	No	No	0	5	4
30	R:R:F309	R:R:V50	6.55	Yes	No	0	8	7
31	R:R:G52	R:R:L65	5.13	No	No	0	4	5
32	R:R:R312	R:R:R54	5.33	No	Yes	0	5	4
33	R:R:R54	R:R:S316	5.27	Yes	No	0	4	5
34	R:R:M55	R:R:T61	4.52	No	No	0	5	7
35	R:R:M55	R:R:R312	6.2	No	No	0	5	5
36	R:R:L65	R:R:R57	3.64	No	No	0	5	6
37	R:R:T58	R:R:T61	4.71	No	No	0	7	7
38	R:R:R137	R:R:V59	14.38	Yes	No	0	7	6
39	R:R:A142	R:R:V59	5.09	No	No	0	7	6
40	R:R:T60	R:R:Y64	6.24	No	Yes	0	7	8
41	R:R:R137	R:R:T60	3.88	Yes	No	0	7	7
42	R:R:I62	R:R:M143	4.37	No	No	0	7	4
43	R:R:I119	R:R:Y64	3.63	Yes	Yes	1	9	8
44	R:R:R123	R:R:Y64	5.14	Yes	Yes	1	9	8
45	R:R:V303	R:R:Y64	13.88	No	Yes	1	7	8
46	R:R:L115	R:R:N66	5.49	No	Yes	0	8	9
47	R:R:I146	R:R:N66	8.5	No	Yes	0	7	9
48	R:R:N66	R:R:W150	12.43	Yes	No	0	9	9
49	R:R:L115	R:R:L67	4.15	No	No	0	8	9
50	R:R:D71	R:R:S295	5.89	No	No	0	9	9
51	R:R:N108	R:R:S73	10.43	No	No	0	8	7
52	R:R:F74	R:R:N108	3.62	Yes	No	0	7	8
53	R:R:F74	R:R:L109	6.09	Yes	Yes	1	7	8
54	R:R:F292	R:R:F74	10.72	Yes	Yes	1	7	7
55	R:R:F74	R:R:S295	6.61	Yes	No	0	7	9
56	R:R:I101	R:R:T77	7.6	Yes	No	0	5	7
57	R:R:T77	R:R:V104	4.76	No	No	0	7	5
58	R:R:F80	R:R:F93	12.86	No	Yes	0	6	7
59	R:R:F80	R:R:I101	8.79	No	Yes	0	6	5
60	R:R:P92	R:R:V83	3.53	No	No	0	3	5
61	R:R:S84	R:R:W91	4.94	No	Yes	0	5	9
62	R:R:M85	R:R:N285	11.22	No	Yes	0	6	4
63	R:R:M87	R:R:P92	6.71	No	No	0	4	3
64	R:R:E89	R:R:Y175	4.49	No	No	0	4	3
65	L:L:K5	R:R:E89	8.1	No	No	0	0	4
66	R:R:D173	R:R:K90	5.53	No	No	0	3	4
67	R:R:F93	R:R:W91	12.03	Yes	Yes	0	7	9
68	R:R:C98	R:R:W91	14.37	No	Yes	0	9	9
69	R:R:I101	R:R:W91	5.87	Yes	Yes	0	5	9
70	R:R:F93	R:R:P92	5.78	Yes	No	0	7	3
71	R:R:F93	R:R:L97	6.09	Yes	No	0	7	7
72	R:R:T165	R:R:W95	4.85	No	No	0	4	4
73	R:R:T166	R:R:W95	3.64	No	No	0	5	4
74	R:R:I101	R:R:L97	4.28	Yes	No	0	5	7
75	R:R:C176	R:R:C98	7.28	No	No	0	9	9
76	R:R:H102	R:R:L164	9	No	No	1	6	5
77	L:L:Y6	R:R:H102	8.71	Yes	No	1	0	6
78	R:R:I103	R:R:V160	4.61	No	No	0	5	4
79	R:R:F161	R:R:I103	13.82	No	No	0	4	5
80	R:R:N108	R:R:V104	4.43	No	No	0	8	5
81	R:R:D106	R:R:V160	7.3	No	No	0	5	4
82	L:L:?9	R:R:D106	10.71	Yes	No	0	0	5
83	R:R:I107	R:R:T157	10.64	No	No	0	5	7
84	R:R:L109	R:R:W254	5.69	Yes	Yes	1	8	9
85	R:R:F292	R:R:L109	7.31	Yes	Yes	1	7	8
86	L:L:?9	R:R:L109	3.64	Yes	Yes	1	0	8
87	R:R:F110	R:R:F114	4.29	Yes	No	0	7	6
88	R:R:F110	R:R:L156	15.83	Yes	No	0	7	5
89	L:L:?9	R:R:F110	18.15	Yes	Yes	0	0	7
90	R:R:P213	R:R:V113	3.53	No	No	0	9	7
91	R:R:F250	R:R:V113	3.93	Yes	No	1	9	7
92	R:R:V113	R:R:W254	6.13	No	Yes	1	7	9
93	R:R:F114	R:R:L152	9.74	No	No	0	6	4
94	R:R:F114	R:R:I208	3.77	No	No	0	6	5
95	R:R:F250	R:R:I116	8.79	Yes	No	1	9	8
96	R:R:I116	R:R:N298	5.66	No	No	1	8	9
97	R:R:I116	R:R:Y302	8.46	No	Yes	1	8	9
98	R:R:F118	R:R:I146	5.02	No	No	0	7	7
99	R:R:I119	R:R:R123	5.01	Yes	Yes	1	9	9
100	R:R:I119	R:R:Y302	4.84	Yes	Yes	1	9	9
101	R:R:A120	R:R:Y221	5.34	No	Yes	0	9	8
102	R:R:D122	R:R:R137	11.91	No	Yes	0	8	7
103	R:R:R123	R:R:Y221	9.26	Yes	Yes	0	9	8
104	R:R:R123	R:R:Y302	8.23	Yes	Yes	1	9	9
105	R:R:C124	R:R:C220	7.28	No	No	0	8	7
106	R:R:I125	R:R:W132	3.52	No	No	0	5	5
107	R:R:C126	R:R:R137	6.96	No	Yes	0	8	7
108	R:R:I224	R:R:V127	9.22	No	No	0	8	8
109	R:R:L128	R:R:L223	6.92	No	No	0	7	3
110	R:R:K227	R:R:L128	4.23	Yes	No	0	5	7
111	R:R:H136	R:R:W132	22.22	No	No	0	3	5
112	R:R:H136	R:R:N135	3.83	No	No	0	3	4
113	R:R:K144	R:R:S140	4.59	No	No	0	1	4
114	R:R:G148	R:R:P149	4.06	No	No	0	3	7
115	R:R:I208	R:R:L156	4.28	No	No	0	5	5
116	R:R:F161	R:R:T157	7.78	No	No	0	4	7
117	R:R:R201	R:R:V160	3.92	Yes	No	0	5	4
118	R:R:F163	R:R:L162	7.31	No	No	0	5	5
119	R:R:L162	R:R:W183	9.11	No	No	0	5	4
120	R:R:F163	R:R:M197	18.66	No	No	0	5	1
121	L:L:Y6	R:R:L164	4.69	Yes	No	1	0	5
122	R:R:N179	R:R:T165	7.31	No	No	0	3	4
123	R:R:C176	R:R:T166	10.14	No	No	0	9	5
124	R:R:I169	R:R:N171	4.25	Yes	No	0	1	4
125	R:R:D173	R:R:I169	4.2	No	Yes	4	3	1
126	R:R:I169	R:R:Y175	3.63	Yes	No	4	1	3
127	R:R:D173	R:R:Y175	9.2	No	No	4	3	3
128	R:R:F178	R:R:T177	5.19	Yes	No	1	4	3
129	L:L:W4	R:R:T177	3.64	Yes	No	1	0	3
130	L:L:Y6	R:R:T177	6.24	Yes	No	1	0	3
131	R:R:F178	R:R:M197	3.73	Yes	No	0	4	1
132	R:R:F178	R:R:R201	4.28	Yes	Yes	1	4	5
133	L:L:W4	R:R:F178	4.01	Yes	Yes	1	0	4
134	L:L:Y6	R:R:F178	5.16	Yes	Yes	1	0	4
135	R:R:F180	R:R:R190	8.55	Yes	Yes	0	6	5
136	R:R:A194	R:R:F180	8.32	No	Yes	0	3	6
137	R:R:P187	R:R:R190	7.21	No	Yes	0	5	5
138	R:R:F273	R:R:L191	3.65	No	No	0	5	1
139	R:R:L198	R:R:L268	4.15	No	No	0	4	3
140	L:L:W4	R:R:L198	5.69	Yes	No	0	0	4
141	R:R:R201	R:R:R205	6.4	Yes	Yes	1	5	5
142	L:L:Y6	R:R:R201	5.14	Yes	Yes	1	0	5
143	L:L:?9	R:R:R201	9.59	Yes	Yes	1	0	5
144	R:R:G202	R:R:T265	5.46	No	No	0	4	4
145	R:R:Q258	R:R:R205	7.01	No	Yes	1	8	5
146	L:L:M7	R:R:R205	7.44	No	Yes	0	0	5
147	L:L:?9	R:R:R205	23.43	Yes	Yes	1	0	5
148	R:R:F206	R:R:F210	4.29	Yes	Yes	1	6	9
149	R:R:F206	R:R:S211	10.57	Yes	No	0	6	4
150	R:R:F206	R:R:Q258	7.03	Yes	No	1	6	8
151	R:R:F206	R:R:L262	7.31	Yes	No	0	6	5
152	R:R:G209	R:R:P213	4.06	No	No	0	6	9
153	R:R:F210	R:R:M214	9.95	Yes	Yes	0	9	6
154	R:R:F210	R:R:F255	8.57	Yes	Yes	0	9	6
155	R:R:F210	R:R:Q258	10.54	Yes	No	1	9	8
156	R:R:L212	R:R:P213	4.93	No	No	0	5	9
157	R:R:I216	R:R:L212	5.71	No	No	0	6	5
158	R:R:F250	R:R:M214	7.46	Yes	Yes	0	9	6
159	R:R:F251	R:R:M214	8.71	No	Yes	0	6	6
160	R:R:I224	R:R:Y221	3.63	No	Yes	0	8	8
161	R:R:L243	R:R:Y221	3.52	No	Yes	0	8	8
162	R:R:V246	R:R:Y221	6.31	Yes	Yes	0	8	8
163	R:R:A225	R:R:L243	4.73	No	No	0	5	8
164	R:R:H229	R:R:I234	3.98	No	Yes	0	3	4
165	R:R:K231	R:R:M233	5.76	No	No	0	5	3
166	R:R:I234	R:R:L240	5.71	Yes	No	0	4	5
167	R:R:V242	R:R:V305	8.02	No	No	0	8	7
168	R:R:L301	R:R:V246	8.94	No	Yes	0	8	8
169	R:R:V246	R:R:Y302	5.05	Yes	Yes	0	8	9
170	R:R:N294	R:R:S249	4.47	Yes	No	0	9	7
171	R:R:F250	R:R:W254	7.02	Yes	Yes	1	9	9
172	R:R:F250	R:R:N294	6.04	Yes	Yes	1	9	9
173	R:R:F251	R:R:F255	9.65	No	Yes	0	6	6
174	R:R:C253	R:R:N294	7.87	No	Yes	0	8	9
175	R:R:A291	R:R:W254	5.19	No	Yes	0	8	9
176	R:R:N294	R:R:W254	9.04	Yes	Yes	1	9	9
177	R:R:F255	R:R:P256	4.33	Yes	No	0	6	9
178	R:R:F255	R:R:L259	6.09	Yes	No	0	6	5
179	R:R:F257	R:R:T287	7.78	No	No	0	7	7
180	R:R:F257	R:R:S288	3.96	No	No	0	7	6
181	R:R:A291	R:R:F257	4.16	No	No	0	8	7
182	R:R:T287	R:R:V260	6.35	No	No	0	7	5
183	R:R:V266	R:R:W267	3.68	No	No	0	4	3
184	R:R:W267	R:R:Y277	15.43	No	No	0	3	3
185	R:R:L268	R:R:L272	6.92	No	No	0	3	3
186	R:R:F273	R:R:K269	4.96	No	No	0	5	4
187	R:R:E270	R:R:Y277	5.61	No	No	0	2	3
188	R:R:D281	R:R:M271	4.16	No	No	0	4	1
189	R:R:K276	R:R:Y277	3.58	No	No	0	1	3
190	R:R:N285	R:R:V284	4.43	Yes	No	3	4	5
191	L:L:K5	R:R:V284	4.55	No	No	3	0	5
192	L:L:M7	R:R:V284	4.56	No	No	0	0	5
193	L:L:K5	R:R:N285	8.39	No	Yes	3	0	4
194	R:R:F292	R:R:S288	5.28	Yes	No	0	7	6
195	R:R:C296	R:R:F293	4.19	No	No	2	8	5
196	R:R:F293	R:R:L297	7.31	No	No	0	5	6
197	R:R:N294	R:R:N298	9.54	Yes	No	1	9	9
198	R:R:N298	R:R:Y302	5.81	No	Yes	1	9	9
199	R:R:F309	R:R:V303	9.18	Yes	No	1	8	7
200	R:R:F304	R:R:F309	11.79	No	Yes	0	7	8
201	L:L:?9	L:L:V8	5.22	Yes	No	0	0	0
202	L:L:W4	R:R:M271	3.49	Yes	No	0	0	1
203	R:R:A120	R:R:V217	3.39	No	No	0	9	8
204	R:R:I169	R:R:P170	3.39	Yes	No	0	1	3
205	R:R:I234	R:R:P239	3.39	Yes	No	0	4	7
206	R:R:L25	R:R:P286	3.28	No	No	0	3	6
207	R:R:L115	R:R:P149	3.28	No	No	0	8	7
208	R:R:L290	R:R:P256	3.28	No	No	0	8	9
209	R:R:C63	R:R:I119	3.27	No	Yes	0	7	9
210	R:R:N285	R:R:P29	3.26	Yes	No	0	4	5
211	R:R:F163	R:R:F180	3.22	No	Yes	0	5	6
212	R:R:F178	R:R:F180	3.22	Yes	Yes	0	4	6
213	R:R:T77	R:R:V105	3.17	No	No	0	7	6
214	R:R:C124	R:R:L128	3.17	No	No	0	8	7
215	R:R:H129	R:R:W132	3.17	No	No	0	6	5
216	R:R:T199	R:R:T265	3.14	No	No	0	3	4
217	R:R:A181	R:R:N179	3.13	No	No	0	5	3
218	R:R:I151	R:R:V147	3.07	No	No	0	3	4
219	R:R:I27	R:R:T23	3.04	No	No	0	6	2
220	R:R:K227	R:R:V127	3.04	Yes	No	0	5	8
221	R:R:F72	R:R:G45	3.01	No	No	0	7	4
222	R:R:K192	R:R:T196	3	No	No	0	5	1
223	R:R:L297	R:R:S249	3	No	No	0	6	7
224	R:R:L100	R:R:V104	2.98	No	No	0	5	5
225	R:R:L141	R:R:V145	2.98	No	No	0	3	5
226	R:R:L283	R:R:V260	2.98	No	No	0	6	5
227	R:R:I228	R:R:I234	2.94	No	Yes	0	8	4
228	R:R:I228	R:R:M233	2.92	No	No	0	8	3
229	R:R:I195	R:R:K192	2.91	No	No	0	1	5
230	R:R:I195	R:R:K269	2.91	No	No	0	1	4
231	R:R:P159	R:R:R201	2.88	No	Yes	0	8	5
232	R:R:P239	R:R:R238	2.88	No	Yes	0	7	7
233	R:R:K227	R:R:K231	2.87	Yes	No	0	5	5
234	R:R:I119	R:R:L67	2.85	Yes	No	0	9	9
235	R:R:I107	R:R:L154	2.85	No	No	0	5	4
236	R:R:I125	R:R:L121	2.85	No	No	0	5	7
237	R:R:I216	R:R:L121	2.85	No	No	0	6	7
238	R:R:E189	R:R:T186	2.82	No	No	0	3	6
239	R:R:A51	R:R:F309	2.77	No	Yes	0	7	8
240	R:R:H129	R:R:V131	2.77	No	No	0	6	5
241	R:R:A261	R:R:R205	2.77	No	Yes	0	5	5
242	R:R:L259	R:R:L263	2.77	No	No	0	5	5
243	R:R:L69	R:R:N66	2.75	No	Yes	0	6	9
244	R:R:F118	R:R:V145	2.62	No	No	0	7	5
245	R:R:A70	R:R:W150	2.59	No	No	0	8	9
246	R:R:V247	R:R:Y221	2.52	No	Yes	0	8	8
247	R:R:I282	R:R:R26	2.51	No	No	0	2	4
248	R:R:F251	R:R:I252	2.51	No	No	0	6	6
249	R:R:F292	R:R:L81	2.44	Yes	No	0	7	6
250	R:R:F96	R:R:L100	2.44	No	No	0	1	5
251	R:R:H315	R:R:R312	2.26	No	No	0	4	5
252	R:R:G184	R:R:G185	2.11	No	No	0	3	3
253	R:R:A153	R:R:G111	1.95	No	No	0	8	7
254	R:R:G21	R:R:V24	1.84	No	No	0	4	4
255	R:R:G117	R:R:V217	1.84	No	No	0	7	8
256	R:R:A133	R:R:C126	1.81	No	No	0	5	8
257	R:R:P239	R:R:S236	1.78	No	No	0	7	6
258	R:R:G34	R:R:I82	1.76	No	No	0	5	7
259	R:R:G45	R:R:I48	1.76	No	No	0	4	7
260	R:R:G264	R:R:I280	1.76	No	No	0	4	4
261	R:R:G88	R:R:M87	1.75	No	No	0	3	4
262	R:R:P187	R:R:T186	1.75	No	No	0	5	6
263	R:R:G264	R:R:M271	1.75	No	No	0	4	1
264	R:R:G43	R:R:L42	1.71	No	No	0	8	4
265	R:R:A70	R:R:S112	1.71	No	No	0	8	9
266	R:R:G94	R:R:L97	1.71	No	No	0	8	7
267	R:R:L28	R:R:P29	1.64	No	No	0	5	5
268	R:R:L158	R:R:P159	1.64	No	No	0	4	8
269	R:R:C220	R:R:I219	1.64	No	No	0	7	3
270	R:R:A142	R:R:I62	1.62	No	No	0	7	7
271	R:R:A200	R:R:I204	1.62	No	No	0	1	4
272	R:R:A218	R:R:M214	1.61	No	Yes	0	5	6
273	R:R:V32	R:R:V35	1.6	No	No	0	5	5
274	R:R:V139	R:R:V59	1.6	No	No	0	3	6
275	R:R:S140	R:R:T138	1.6	No	No	0	4	6
276	R:R:V242	R:R:V246	1.6	No	Yes	0	8	8
277	R:R:T23	R:R:V24	1.59	No	No	0	2	4
278	R:R:A245	R:R:L301	1.58	No	No	0	6	8
279	R:R:T56	R:R:T58	1.57	No	No	0	6	7
280	R:R:I216	R:R:S215	1.55	No	No	0	6	3
281	R:R:I27	R:R:V31	1.54	No	No	0	6	6
282	R:R:I146	R:R:V147	1.54	No	No	0	7	4
283	R:R:I169	R:R:V167	1.54	Yes	No	0	1	1
284	R:R:I203	R:R:V207	1.54	No	No	0	4	4
285	R:R:H129	R:R:P130	1.53	No	No	0	6	8
286	R:R:I203	R:R:T199	1.52	No	No	0	4	3
287	R:R:K90	R:R:T174	1.5	No	No	0	4	5
288	R:R:K99	R:R:T165	1.5	No	No	0	7	4
289	R:R:G184	R:R:R190	1.5	No	Yes	0	3	5
290	R:R:G202	R:R:R201	1.5	No	Yes	1	4	5
291	R:R:G202	R:R:R205	1.5	No	Yes	1	4	5
292	R:R:G306	R:R:R238	1.5	No	Yes	0	8	7
293	R:R:L141	R:R:T138	1.47	No	No	0	3	6
294	R:R:G275	R:R:Y274	1.45	No	No	0	1	5
295	R:R:K227	R:R:K230	1.44	Yes	No	0	5	4
296	R:R:I48	R:R:L65	1.43	No	No	0	7	5
297	R:R:I204	R:R:L156	1.43	No	No	0	4	5
298	R:R:I195	R:R:L272	1.43	No	No	0	1	3
299	R:R:A153	R:R:F110	1.39	No	Yes	0	8	7
300	R:R:E270	R:R:K269	1.35	No	No	0	2	4
301	R:R:R241	R:R:S237	1.32	No	No	0	5	4
302	R:R:F37	R:R:V38	1.31	Yes	No	0	6	5
303	R:R:R190	R:R:V193	1.31	Yes	No	0	5	4
304	R:R:D308	R:R:Q307	1.31	No	No	0	6	5
305	R:R:E311	R:R:H315	1.23	No	No	0	4	4
306	R:R:Q307	R:R:R238	1.17	No	Yes	0	5	7
307	R:R:E270	R:R:Y274	1.12	No	No	0	2	5
308	R:R:F53	R:R:R54	1.07	No	Yes	0	4	4
309	R:R:R238	R:R:R310	1.07	Yes	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L33	5.6025	4	0	7
2	R:R:F37	5.36	4	0	6
3	R:R:N44	7.975	4	0	9
4	R:R:R54	5.6675	4	0	4
5	R:R:Y64	7.2225	4	1	8
6	R:R:N66	7.2925	4	0	9
7	R:R:F74	6.76	4	1	7
8	R:R:W91	9.3025	4	0	9
9	R:R:F93	9.19	4	0	7
10	R:R:I101	6.635	4	0	5
11	R:R:L109	5.6825	4	1	8
12	R:R:F110	9.915	4	0	7
13	R:R:I119	3.92	5	1	9
14	R:R:R123	6.91	4	1	9
15	R:R:R137	9.2825	4	0	7
16	R:R:I169	3.402	5	4	1
17	R:R:F178	4.265	6	1	4
18	R:R:F180	5.8275	4	0	6
19	R:R:R190	4.6425	4	0	5
20	R:R:R201	4.81571	7	1	5
21	R:R:R205	8.09167	6	1	5
22	R:R:F206	7.3	4	1	6
23	R:R:F210	8.3375	4	1	9
24	R:R:M214	6.9325	4	0	6
25	R:R:Y221	5.09667	6	0	8
26	R:R:K227	2.895	4	0	5
27	R:R:I234	4.005	4	0	4
28	R:R:R238	1.655	4	0	7
29	R:R:V246	5.475	4	0	8
30	R:R:F250	6.648	5	1	9
31	R:R:W254	6.614	5	1	9
32	R:R:F255	7.16	4	0	6
33	R:R:N285	6.825	4	3	4
34	R:R:F292	5.88	5	1	7
35	R:R:N294	7.392	5	1	9
36	R:R:Y302	6.478	5	1	9
37	R:R:F309	7.106	5	1	8
38	L:L:W4	4.2075	4	1	0
39	L:L:Y6	5.988	5	1	0
40	L:L:?9	11.79	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N285	R:R:V284	10.6797	4.43	Yes	No	3	4	5
2	L:L:M7	R:R:V284	25.4591	4.56	No	No	0	0	5
3	L:L:M7	R:R:R205	26.7542	7.44	No	Yes	0	0	5
4	L:L:?9	R:R:R205	26.0901	23.43	Yes	Yes	1	0	5
5	L:L:?9	R:R:L109	89.1977	3.64	Yes	Yes	1	0	8
6	R:R:F292	R:R:L109	14.2022	7.31	Yes	Yes	1	7	8
7	R:R:F292	R:R:L33	12.6133	3.65	Yes	Yes	0	7	7
8	R:R:N294	R:R:W254	49.4444	9.04	Yes	Yes	1	9	9
9	R:R:L109	R:R:W254	100	5.69	Yes	Yes	1	8	9
10	R:R:D71	R:R:N44	15.5636	16.16	No	Yes	0	9	9
11	R:R:D71	R:R:S295	15.8599	5.89	No	No	0	9	9
12	R:R:F74	R:R:S295	16.5981	6.61	Yes	No	0	7	9
13	R:R:F74	R:R:L109	45.6282	6.09	Yes	Yes	1	7	8
14	R:R:N44	R:R:P299	12.7283	6.52	Yes	No	0	9	9
15	R:R:P299	R:R:V47	12.5495	5.3	No	No	0	9	9
16	R:R:Q258	R:R:R205	12.9275	7.01	No	Yes	1	8	5
17	R:R:F210	R:R:Q258	11.7857	10.54	Yes	No	1	9	8
18	R:R:F210	R:R:M214	14.1357	9.95	Yes	Yes	0	9	6
19	R:R:F250	R:R:M214	18.9532	7.46	Yes	Yes	0	9	6
20	R:R:F250	R:R:I116	65.5777	8.79	Yes	No	1	9	8
21	R:R:I116	R:R:Y302	65.2507	8.46	No	Yes	1	8	9
22	R:R:I119	R:R:Y302	35.6995	4.84	Yes	Yes	1	9	9
23	R:R:I119	R:R:Y64	17.3644	3.63	Yes	Yes	1	9	8
24	R:R:V303	R:R:Y64	14.7207	13.88	No	Yes	1	7	8
25	R:R:F250	R:R:W254	48.5198	7.02	Yes	Yes	1	9	9
26	R:R:N294	R:R:N298	48.6577	9.54	Yes	No	1	9	9
27	R:R:N298	R:R:Y302	48.4763	5.81	No	Yes	1	9	9
28	R:R:R123	R:R:Y302	44.9284	8.23	Yes	Yes	1	9	9
29	R:R:R123	R:R:Y64	18.9583	5.14	Yes	Yes	1	9	8
30	R:R:F309	R:R:V50	12.2736	6.55	Yes	No	0	8	7
31	R:R:V50	R:R:W49	11.3975	3.68	No	No	0	7	4
32	R:R:T60	R:R:Y64	23.4489	6.24	No	Yes	0	7	8
33	R:R:R137	R:R:T60	21.0938	3.88	Yes	No	0	7	7
34	R:R:R137	R:R:V59	11.9364	14.38	Yes	No	0	7	6
35	R:R:L115	R:R:L67	20.8843	4.15	No	No	0	8	9
36	R:R:I119	R:R:L67	22.067	2.85	Yes	No	0	9	9
37	R:R:L115	R:R:N66	17.3057	5.49	No	Yes	0	8	9
38	R:R:I146	R:R:N66	11.2391	8.5	No	Yes	0	7	9
39	R:R:F74	R:R:N108	39.5157	3.62	Yes	No	0	7	8
40	R:R:I101	R:R:T77	32.2741	7.6	Yes	No	0	5	7
41	R:R:T77	R:R:V104	34.3687	4.76	No	No	0	7	5
42	R:R:N108	R:R:V104	37.4722	4.43	No	No	0	8	5
43	R:R:I101	R:R:W91	16.8817	5.87	Yes	Yes	0	5	9
44	R:R:F93	R:R:P92	13.5533	5.78	Yes	No	0	7	3
45	L:L:K5	R:R:E89	12.4345	8.1	No	No	0	0	4
46	R:R:E89	R:R:Y175	11.2366	4.49	No	No	0	4	3
47	R:R:I103	R:R:V160	10.1254	4.61	No	No	0	5	4
48	L:L:?9	R:R:F110	11.5431	18.15	Yes	Yes	0	0	7
49	R:R:P213	R:R:V113	12.1178	3.53	No	No	0	9	7
50	R:R:R123	R:R:Y221	34.1873	9.26	Yes	Yes	0	9	8
51	R:R:V246	R:R:Y221	29.7658	6.31	Yes	Yes	0	8	8
52	R:R:V246	R:R:Y302	35.1605	5.05	Yes	Yes	0	8	9
53	R:R:K227	R:R:L128	11.377	4.23	Yes	No	0	5	7
54	R:R:K227	R:R:V127	43.9781	3.04	Yes	No	0	5	8
55	R:R:I224	R:R:V127	46.1749	9.22	No	No	0	8	8
56	R:R:I224	R:R:Y221	48.3563	3.63	No	Yes	0	8	8
57	R:R:L212	R:R:P213	10.3093	4.93	No	No	0	5	9
58	R:R:F178	R:R:R201	39.5821	4.28	Yes	Yes	1	4	5
59	R:R:F178	R:R:F180	12.8049	3.22	Yes	Yes	0	4	6
60	L:L:W4	R:R:F178	22.6315	4.01	Yes	Yes	1	0	4
61	R:R:I195	R:R:K269	11.2314	2.91	No	No	0	1	4
62	R:R:I195	R:R:L272	14.5036	1.43	No	No	0	1	3
63	R:R:L268	R:R:L272	15.5866	6.92	No	No	0	3	3
64	R:R:L198	R:R:L268	16.6594	4.15	No	No	0	4	3
65	L:L:W4	R:R:L198	17.7042	5.69	Yes	No	0	0	4
66	R:R:I228	R:R:I234	21.8269	2.94	No	Yes	0	8	4
67	R:R:I228	R:R:M233	24.0645	2.92	No	No	0	8	3
68	R:R:K231	R:R:M233	26.297	5.76	No	No	0	5	3
69	R:R:K227	R:R:K231	28.5244	2.87	Yes	No	0	5	5
70	R:R:I234	R:R:P239	15.0834	3.39	Yes	No	0	4	7
71	R:R:P239	R:R:R238	10.5622	2.88	No	Yes	0	7	7
72	L:L:K5	R:R:V284	13.4435	4.55	No	No	3	0	5
73	L:L:?9	R:R:R201	49.8889	9.59	Yes	Yes	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F74	R:R:L109	6.09	1	Yes	Yes	7	8	2	1
R:R:F292	R:R:F74	10.72	1	Yes	Yes	7	7	2	2
R:R:M85	R:R:N285	11.22	0	No	Yes	6	4	2	1
R:R:E89	R:R:Y175	4.49	0	No	No	4	3	1	2
L:L:K5	R:R:E89	8.1	3	No	No	0	4	0	1
R:R:H102	R:R:L164	9	1	No	No	6	5	1	1
L:L:Y6	R:R:H102	8.71	1	Yes	No	0	6	0	1
R:R:D106	R:R:V160	7.3	0	No	No	5	4	1	2
L:L:?9	R:R:D106	10.71	1	Yes	No	0	5	0	1
R:R:L109	R:R:W254	5.69	1	Yes	Yes	8	9	1	2
R:R:F292	R:R:L109	7.31	1	Yes	Yes	7	8	2	1
L:L:?9	R:R:L109	3.64	1	Yes	Yes	0	8	0	1
R:R:F110	R:R:F114	4.29	0	Yes	No	7	6	1	2
R:R:F110	R:R:L156	15.83	0	Yes	No	7	5	1	2
L:L:?9	R:R:F110	18.15	1	Yes	Yes	0	7	0	1
R:R:R201	R:R:V160	3.92	1	Yes	No	5	4	1	2
L:L:Y6	R:R:L164	4.69	1	Yes	No	0	5	0	1
R:R:F178	R:R:T177	5.19	1	Yes	No	4	3	1	1
L:L:W4	R:R:T177	3.64	1	Yes	No	0	3	0	1
L:L:Y6	R:R:T177	6.24	1	Yes	No	0	3	0	1
R:R:F178	R:R:M197	3.73	1	Yes	No	4	1	1	2
R:R:F178	R:R:R201	4.28	1	Yes	Yes	4	5	1	1
L:L:W4	R:R:F178	4.01	1	Yes	Yes	0	4	0	1
L:L:Y6	R:R:F178	5.16	1	Yes	Yes	0	4	0	1
R:R:L198	R:R:L268	4.15	0	No	No	4	3	1	2
L:L:W4	R:R:L198	5.69	1	Yes	No	0	4	0	1
R:R:R201	R:R:R205	6.4	1	Yes	Yes	5	5	1	1
L:L:Y6	R:R:R201	5.14	1	Yes	Yes	0	5	0	1
L:L:?9	R:R:R201	9.59	1	Yes	Yes	0	5	0	1
R:R:Q258	R:R:R205	7.01	1	No	Yes	8	5	2	1
L:L:M7	R:R:R205	7.44	0	No	Yes	0	5	0	1
L:L:?9	R:R:R205	23.43	1	Yes	Yes	0	5	0	1
R:R:D281	R:R:M271	4.16	0	No	No	4	1	2	1
R:R:N285	R:R:V284	4.43	3	Yes	No	4	5	1	1
L:L:K5	R:R:V284	4.55	3	No	No	0	5	0	1
L:L:M7	R:R:V284	4.56	0	No	No	0	5	0	1
L:L:K5	R:R:N285	8.39	3	No	Yes	0	4	0	1
L:L:W4	R:R:M271	3.49	1	Yes	No	0	1	0	1
R:R:N285	R:R:P29	3.26	3	Yes	No	4	5	1	2
R:R:F178	R:R:F180	3.22	1	Yes	Yes	4	6	1	2
R:R:P159	R:R:R201	2.88	0	No	Yes	8	5	2	1
R:R:A261	R:R:R205	2.77	0	No	Yes	5	5	2	1
R:R:G264	R:R:M271	1.75	0	No	No	4	1	2	1
R:R:G202	R:R:R201	1.5	1	No	Yes	4	5	2	1
R:R:G202	R:R:R205	1.5	1	No	Yes	4	5	2	1
R:R:A153	R:R:F110	1.39	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OMM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	286
Number of Links	309
Number of Hubs	40
Number of Links mediated by Hubs	147
Number of Communities	4
Number of Nodes involved in Communities	38
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	76207
Length Of Smallest Path	3
Average Path Length	14.4822
Length of Longest Path	31
Minimum Path Strength	1.18333
Average Path Strength	6.24097
Maximum Path Strength	20.79
Minimum Path Correlation	0.7
Average Path Correlation	0.92827
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.3716
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.1309
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	QXV
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	QXV
Name	D-methioninamide
Synonyms
Identifier
Formula	C5 H12 N2 O S
Molecular Weight	148.227
SMILES
PubChem	11571827
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>6OMM_nogp_Chain_R G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188

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