psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P286	R:R:P29	7.79	No	No	0	6	5
2	R:R:L30	R:R:M85	4.24	No	No	0	5	6
3	R:R:A86	R:R:L30	4.73	No	No	0	4	5
4	R:R:S289	R:R:V32	4.85	No	No	0	5	5
5	R:R:L33	R:R:L78	5.54	Yes	No	0	7	8
6	R:R:I82	R:R:L33	5.71	No	Yes	0	7	7
7	R:R:L33	R:R:S289	7.51	Yes	No	0	7	5
8	R:R:F292	R:R:L33	3.65	Yes	Yes	0	7	7
9	R:R:F293	R:R:T36	3.89	No	No	2	5	7
10	R:R:C296	R:R:T36	10.14	No	No	2	8	7
11	R:R:F37	R:R:V41	3.93	Yes	No	0	6	6
12	R:R:F37	R:R:L78	6.09	Yes	No	0	6	8
13	R:R:F37	R:R:P79	10.11	Yes	No	0	6	8
14	R:R:C296	R:R:L39	6.35	No	No	0	8	5
15	R:R:L39	R:R:M300	5.65	No	No	0	5	7
16	R:R:G40	R:R:T75	3.64	No	No	0	8	7
17	R:R:D71	R:R:N44	16.16	No	Yes	0	9	9
18	R:R:F72	R:R:N44	4.83	No	Yes	0	7	9
19	R:R:N44	R:R:T75	4.39	Yes	No	0	9	7
20	R:R:N44	R:R:P299	6.52	Yes	No	0	9	9
21	R:R:F304	R:R:L46	3.65	No	No	0	7	6
22	R:R:L313	R:R:L46	6.92	No	No	0	6	6
23	R:R:P299	R:R:V47	5.3	No	No	0	9	9
24	R:R:V303	R:R:V47	4.81	No	No	1	7	9
25	R:R:F309	R:R:V47	5.24	Yes	No	1	8	9
26	R:R:A68	R:R:I48	4.87	No	No	0	8	7
27	R:R:V50	R:R:W49	3.68	No	No	0	7	4
28	R:R:R54	R:R:W49	11	Yes	No	0	4	4
29	R:R:L317	R:R:W49	5.69	No	No	0	5	4
30	R:R:F309	R:R:V50	6.55	Yes	No	0	8	7
31	R:R:G52	R:R:L65	5.13	No	No	0	4	5
32	R:R:R312	R:R:R54	5.33	No	Yes	0	5	4
33	R:R:R54	R:R:S316	5.27	Yes	No	0	4	5
34	R:R:M55	R:R:T61	4.52	No	No	0	5	7
35	R:R:M55	R:R:R312	6.2	No	No	0	5	5
36	R:R:L65	R:R:R57	3.64	No	No	0	5	6
37	R:R:T58	R:R:T61	4.71	No	No	0	7	7
38	R:R:R137	R:R:V59	14.38	Yes	No	0	7	6
39	R:R:A142	R:R:V59	5.09	No	No	0	7	6
40	R:R:T60	R:R:Y64	6.24	No	Yes	0	7	8
41	R:R:R137	R:R:T60	3.88	Yes	No	0	7	7
42	R:R:I62	R:R:M143	4.37	No	No	0	7	4
43	R:R:I119	R:R:Y64	3.63	Yes	Yes	1	9	8
44	R:R:R123	R:R:Y64	5.14	Yes	Yes	1	9	8
45	R:R:V303	R:R:Y64	13.88	No	Yes	1	7	8
46	R:R:L115	R:R:N66	5.49	No	Yes	0	8	9
47	R:R:I146	R:R:N66	8.5	No	Yes	0	7	9
48	R:R:N66	R:R:W150	12.43	Yes	No	0	9	9
49	R:R:L115	R:R:L67	4.15	No	No	0	8	9
50	R:R:D71	R:R:S295	5.89	No	No	0	9	9
51	R:R:N108	R:R:S73	10.43	No	No	0	8	7
52	R:R:F74	R:R:N108	3.62	Yes	No	0	7	8
53	R:R:F74	R:R:L109	6.09	Yes	Yes	1	7	8
54	R:R:F292	R:R:F74	10.72	Yes	Yes	1	7	7
55	R:R:F74	R:R:S295	6.61	Yes	No	0	7	9
56	R:R:I101	R:R:T77	7.6	Yes	No	0	5	7
57	R:R:T77	R:R:V104	4.76	No	No	0	7	5
58	R:R:F80	R:R:F93	12.86	No	Yes	0	6	7
59	R:R:F80	R:R:I101	8.79	No	Yes	0	6	5
60	R:R:P92	R:R:V83	3.53	No	No	0	3	5
61	R:R:S84	R:R:W91	4.94	No	Yes	0	5	9
62	R:R:M85	R:R:N285	11.22	No	Yes	0	6	4
63	R:R:M87	R:R:P92	6.71	No	No	0	4	3
64	R:R:E89	R:R:Y175	4.49	No	No	0	4	3
65	L:L:K5	R:R:E89	8.1	No	No	0	0	4
66	R:R:D173	R:R:K90	5.53	No	No	0	3	4
67	R:R:F93	R:R:W91	12.03	Yes	Yes	0	7	9
68	R:R:C98	R:R:W91	14.37	No	Yes	0	9	9
69	R:R:I101	R:R:W91	5.87	Yes	Yes	0	5	9
70	R:R:F93	R:R:P92	5.78	Yes	No	0	7	3
71	R:R:F93	R:R:L97	6.09	Yes	No	0	7	7
72	R:R:T165	R:R:W95	4.85	No	No	0	4	4
73	R:R:T166	R:R:W95	3.64	No	No	0	5	4
74	R:R:I101	R:R:L97	4.28	Yes	No	0	5	7
75	R:R:C176	R:R:C98	7.28	No	No	0	9	9
76	R:R:H102	R:R:L164	9	No	No	1	6	5
77	L:L:Y6	R:R:H102	8.71	Yes	No	1	0	6
78	R:R:I103	R:R:V160	4.61	No	No	0	5	4
79	R:R:F161	R:R:I103	13.82	No	No	0	4	5
80	R:R:N108	R:R:V104	4.43	No	No	0	8	5
81	R:R:D106	R:R:V160	7.3	No	No	0	5	4
82	L:L:?9	R:R:D106	10.71	Yes	No	0	0	5
83	R:R:I107	R:R:T157	10.64	No	No	0	5	7
84	R:R:L109	R:R:W254	5.69	Yes	Yes	1	8	9
85	R:R:F292	R:R:L109	7.31	Yes	Yes	1	7	8
86	L:L:?9	R:R:L109	3.64	Yes	Yes	1	0	8
87	R:R:F110	R:R:F114	4.29	Yes	No	0	7	6
88	R:R:F110	R:R:L156	15.83	Yes	No	0	7	5
89	L:L:?9	R:R:F110	18.15	Yes	Yes	0	0	7
90	R:R:P213	R:R:V113	3.53	No	No	0	9	7
91	R:R:F250	R:R:V113	3.93	Yes	No	1	9	7
92	R:R:V113	R:R:W254	6.13	No	Yes	1	7	9
93	R:R:F114	R:R:L152	9.74	No	No	0	6	4
94	R:R:F114	R:R:I208	3.77	No	No	0	6	5
95	R:R:F250	R:R:I116	8.79	Yes	No	1	9	8
96	R:R:I116	R:R:N298	5.66	No	No	1	8	9
97	R:R:I116	R:R:Y302	8.46	No	Yes	1	8	9
98	R:R:F118	R:R:I146	5.02	No	No	0	7	7
99	R:R:I119	R:R:R123	5.01	Yes	Yes	1	9	9
100	R:R:I119	R:R:Y302	4.84	Yes	Yes	1	9	9
101	R:R:A120	R:R:Y221	5.34	No	Yes	0	9	8
102	R:R:D122	R:R:R137	11.91	No	Yes	0	8	7
103	R:R:R123	R:R:Y221	9.26	Yes	Yes	0	9	8
104	R:R:R123	R:R:Y302	8.23	Yes	Yes	1	9	9
105	R:R:C124	R:R:C220	7.28	No	No	0	8	7
106	R:R:I125	R:R:W132	3.52	No	No	0	5	5
107	R:R:C126	R:R:R137	6.96	No	Yes	0	8	7
108	R:R:I224	R:R:V127	9.22	No	No	0	8	8
109	R:R:L128	R:R:L223	6.92	No	No	0	7	3
110	R:R:K227	R:R:L128	4.23	Yes	No	0	5	7
111	R:R:H136	R:R:W132	22.22	No	No	0	3	5
112	R:R:H136	R:R:N135	3.83	No	No	0	3	4
113	R:R:K144	R:R:S140	4.59	No	No	0	1	4
114	R:R:G148	R:R:P149	4.06	No	No	0	3	7
115	R:R:I208	R:R:L156	4.28	No	No	0	5	5
116	R:R:F161	R:R:T157	7.78	No	No	0	4	7
117	R:R:R201	R:R:V160	3.92	Yes	No	0	5	4
118	R:R:F163	R:R:L162	7.31	No	No	0	5	5
119	R:R:L162	R:R:W183	9.11	No	No	0	5	4
120	R:R:F163	R:R:M197	18.66	No	No	0	5	1
121	L:L:Y6	R:R:L164	4.69	Yes	No	1	0	5
122	R:R:N179	R:R:T165	7.31	No	No	0	3	4
123	R:R:C176	R:R:T166	10.14	No	No	0	9	5
124	R:R:I169	R:R:N171	4.25	Yes	No	0	1	4
125	R:R:D173	R:R:I169	4.2	No	Yes	4	3	1
126	R:R:I169	R:R:Y175	3.63	Yes	No	4	1	3
127	R:R:D173	R:R:Y175	9.2	No	No	4	3	3
128	R:R:F178	R:R:T177	5.19	Yes	No	1	4	3
129	L:L:W4	R:R:T177	3.64	Yes	No	1	0	3
130	L:L:Y6	R:R:T177	6.24	Yes	No	1	0	3
131	R:R:F178	R:R:M197	3.73	Yes	No	0	4	1
132	R:R:F178	R:R:R201	4.28	Yes	Yes	1	4	5
133	L:L:W4	R:R:F178	4.01	Yes	Yes	1	0	4
134	L:L:Y6	R:R:F178	5.16	Yes	Yes	1	0	4
135	R:R:F180	R:R:R190	8.55	Yes	Yes	0	6	5
136	R:R:A194	R:R:F180	8.32	No	Yes	0	3	6
137	R:R:P187	R:R:R190	7.21	No	Yes	0	5	5
138	R:R:F273	R:R:L191	3.65	No	No	0	5	1
139	R:R:L198	R:R:L268	4.15	No	No	0	4	3
140	L:L:W4	R:R:L198	5.69	Yes	No	0	0	4
141	R:R:R201	R:R:R205	6.4	Yes	Yes	1	5	5
142	L:L:Y6	R:R:R201	5.14	Yes	Yes	1	0	5
143	L:L:?9	R:R:R201	9.59	Yes	Yes	1	0	5
144	R:R:G202	R:R:T265	5.46	No	No	0	4	4
145	R:R:Q258	R:R:R205	7.01	No	Yes	1	8	5
146	L:L:M7	R:R:R205	7.44	No	Yes	0	0	5
147	L:L:?9	R:R:R205	23.43	Yes	Yes	1	0	5
148	R:R:F206	R:R:F210	4.29	Yes	Yes	1	6	9
149	R:R:F206	R:R:S211	10.57	Yes	No	0	6	4
150	R:R:F206	R:R:Q258	7.03	Yes	No	1	6	8
151	R:R:F206	R:R:L262	7.31	Yes	No	0	6	5
152	R:R:G209	R:R:P213	4.06	No	No	0	6	9
153	R:R:F210	R:R:M214	9.95	Yes	Yes	0	9	6
154	R:R:F210	R:R:F255	8.57	Yes	Yes	0	9	6
155	R:R:F210	R:R:Q258	10.54	Yes	No	1	9	8
156	R:R:L212	R:R:P213	4.93	No	No	0	5	9
157	R:R:I216	R:R:L212	5.71	No	No	0	6	5
158	R:R:F250	R:R:M214	7.46	Yes	Yes	0	9	6
159	R:R:F251	R:R:M214	8.71	No	Yes	0	6	6
160	R:R:I224	R:R:Y221	3.63	No	Yes	0	8	8
161	R:R:L243	R:R:Y221	3.52	No	Yes	0	8	8
162	R:R:V246	R:R:Y221	6.31	Yes	Yes	0	8	8
163	R:R:A225	R:R:L243	4.73	No	No	0	5	8
164	R:R:H229	R:R:I234	3.98	No	Yes	0	3	4
165	R:R:K231	R:R:M233	5.76	No	No	0	5	3
166	R:R:I234	R:R:L240	5.71	Yes	No	0	4	5
167	R:R:V242	R:R:V305	8.02	No	No	0	8	7
168	R:R:L301	R:R:V246	8.94	No	Yes	0	8	8
169	R:R:V246	R:R:Y302	5.05	Yes	Yes	0	8	9
170	R:R:N294	R:R:S249	4.47	Yes	No	0	9	7
171	R:R:F250	R:R:W254	7.02	Yes	Yes	1	9	9
172	R:R:F250	R:R:N294	6.04	Yes	Yes	1	9	9
173	R:R:F251	R:R:F255	9.65	No	Yes	0	6	6
174	R:R:C253	R:R:N294	7.87	No	Yes	0	8	9
175	R:R:A291	R:R:W254	5.19	No	Yes	0	8	9
176	R:R:N294	R:R:W254	9.04	Yes	Yes	1	9	9
177	R:R:F255	R:R:P256	4.33	Yes	No	0	6	9
178	R:R:F255	R:R:L259	6.09	Yes	No	0	6	5
179	R:R:F257	R:R:T287	7.78	No	No	0	7	7
180	R:R:F257	R:R:S288	3.96	No	No	0	7	6
181	R:R:A291	R:R:F257	4.16	No	No	0	8	7
182	R:R:T287	R:R:V260	6.35	No	No	0	7	5
183	R:R:V266	R:R:W267	3.68	No	No	0	4	3
184	R:R:W267	R:R:Y277	15.43	No	No	0	3	3
185	R:R:L268	R:R:L272	6.92	No	No	0	3	3
186	R:R:F273	R:R:K269	4.96	No	No	0	5	4
187	R:R:E270	R:R:Y277	5.61	No	No	0	2	3
188	R:R:D281	R:R:M271	4.16	No	No	0	4	1
189	R:R:K276	R:R:Y277	3.58	No	No	0	1	3
190	R:R:N285	R:R:V284	4.43	Yes	No	3	4	5
191	L:L:K5	R:R:V284	4.55	No	No	3	0	5
192	L:L:M7	R:R:V284	4.56	No	No	0	0	5
193	L:L:K5	R:R:N285	8.39	No	Yes	3	0	4
194	R:R:F292	R:R:S288	5.28	Yes	No	0	7	6
195	R:R:C296	R:R:F293	4.19	No	No	2	8	5
196	R:R:F293	R:R:L297	7.31	No	No	0	5	6
197	R:R:N294	R:R:N298	9.54	Yes	No	1	9	9
198	R:R:N298	R:R:Y302	5.81	No	Yes	1	9	9
199	R:R:F309	R:R:V303	9.18	Yes	No	1	8	7
200	R:R:F304	R:R:F309	11.79	No	Yes	0	7	8
201	L:L:?9	L:L:V8	5.22	Yes	No	0	0	0
202	L:L:W4	R:R:M271	3.49	Yes	No	0	0	1
203	R:R:A120	R:R:V217	3.39	No	No	0	9	8
204	R:R:I169	R:R:P170	3.39	Yes	No	0	1	3
205	R:R:I234	R:R:P239	3.39	Yes	No	0	4	7
206	R:R:L25	R:R:P286	3.28	No	No	0	3	6
207	R:R:L115	R:R:P149	3.28	No	No	0	8	7
208	R:R:L290	R:R:P256	3.28	No	No	0	8	9
209	R:R:C63	R:R:I119	3.27	No	Yes	0	7	9
210	R:R:N285	R:R:P29	3.26	Yes	No	0	4	5
211	R:R:F163	R:R:F180	3.22	No	Yes	0	5	6
212	R:R:F178	R:R:F180	3.22	Yes	Yes	0	4	6
213	R:R:T77	R:R:V105	3.17	No	No	0	7	6
214	R:R:C124	R:R:L128	3.17	No	No	0	8	7
215	R:R:H129	R:R:W132	3.17	No	No	0	6	5
216	R:R:T199	R:R:T265	3.14	No	No	0	3	4
217	R:R:A181	R:R:N179	3.13	No	No	0	5	3
218	R:R:I151	R:R:V147	3.07	No	No	0	3	4
219	R:R:I27	R:R:T23	3.04	No	No	0	6	2
220	R:R:K227	R:R:V127	3.04	Yes	No	0	5	8
221	R:R:F72	R:R:G45	3.01	No	No	0	7	4
222	R:R:K192	R:R:T196	3	No	No	0	5	1
223	R:R:L297	R:R:S249	3	No	No	0	6	7
224	R:R:L100	R:R:V104	2.98	No	No	0	5	5
225	R:R:L141	R:R:V145	2.98	No	No	0	3	5
226	R:R:L283	R:R:V260	2.98	No	No	0	6	5
227	R:R:I228	R:R:I234	2.94	No	Yes	0	8	4
228	R:R:I228	R:R:M233	2.92	No	No	0	8	3
229	R:R:I195	R:R:K192	2.91	No	No	0	1	5
230	R:R:I195	R:R:K269	2.91	No	No	0	1	4
231	R:R:P159	R:R:R201	2.88	No	Yes	0	8	5
232	R:R:P239	R:R:R238	2.88	No	Yes	0	7	7
233	R:R:K227	R:R:K231	2.87	Yes	No	0	5	5
234	R:R:I119	R:R:L67	2.85	Yes	No	0	9	9
235	R:R:I107	R:R:L154	2.85	No	No	0	5	4
236	R:R:I125	R:R:L121	2.85	No	No	0	5	7
237	R:R:I216	R:R:L121	2.85	No	No	0	6	7
238	R:R:E189	R:R:T186	2.82	No	No	0	3	6
239	R:R:A51	R:R:F309	2.77	No	Yes	0	7	8
240	R:R:H129	R:R:V131	2.77	No	No	0	6	5
241	R:R:A261	R:R:R205	2.77	No	Yes	0	5	5
242	R:R:L259	R:R:L263	2.77	No	No	0	5	5
243	R:R:L69	R:R:N66	2.75	No	Yes	0	6	9
244	R:R:F118	R:R:V145	2.62	No	No	0	7	5
245	R:R:A70	R:R:W150	2.59	No	No	0	8	9
246	R:R:V247	R:R:Y221	2.52	No	Yes	0	8	8
247	R:R:I282	R:R:R26	2.51	No	No	0	2	4
248	R:R:F251	R:R:I252	2.51	No	No	0	6	6
249	R:R:F292	R:R:L81	2.44	Yes	No	0	7	6
250	R:R:F96	R:R:L100	2.44	No	No	0	1	5
251	R:R:H315	R:R:R312	2.26	No	No	0	4	5
252	R:R:G184	R:R:G185	2.11	No	No	0	3	3
253	R:R:A153	R:R:G111	1.95	No	No	0	8	7
254	R:R:G21	R:R:V24	1.84	No	No	0	4	4
255	R:R:G117	R:R:V217	1.84	No	No	0	7	8
256	R:R:A133	R:R:C126	1.81	No	No	0	5	8
257	R:R:P239	R:R:S236	1.78	No	No	0	7	6
258	R:R:G34	R:R:I82	1.76	No	No	0	5	7
259	R:R:G45	R:R:I48	1.76	No	No	0	4	7
260	R:R:G264	R:R:I280	1.76	No	No	0	4	4
261	R:R:G88	R:R:M87	1.75	No	No	0	3	4
262	R:R:P187	R:R:T186	1.75	No	No	0	5	6
263	R:R:G264	R:R:M271	1.75	No	No	0	4	1
264	R:R:G43	R:R:L42	1.71	No	No	0	8	4
265	R:R:A70	R:R:S112	1.71	No	No	0	8	9
266	R:R:G94	R:R:L97	1.71	No	No	0	8	7
267	R:R:L28	R:R:P29	1.64	No	No	0	5	5
268	R:R:L158	R:R:P159	1.64	No	No	0	4	8
269	R:R:C220	R:R:I219	1.64	No	No	0	7	3
270	R:R:A142	R:R:I62	1.62	No	No	0	7	7
271	R:R:A200	R:R:I204	1.62	No	No	0	1	4
272	R:R:A218	R:R:M214	1.61	No	Yes	0	5	6
273	R:R:V32	R:R:V35	1.6	No	No	0	5	5
274	R:R:V139	R:R:V59	1.6	No	No	0	3	6
275	R:R:S140	R:R:T138	1.6	No	No	0	4	6
276	R:R:V242	R:R:V246	1.6	No	Yes	0	8	8
277	R:R:T23	R:R:V24	1.59	No	No	0	2	4
278	R:R:A245	R:R:L301	1.58	No	No	0	6	8
279	R:R:T56	R:R:T58	1.57	No	No	0	6	7
280	R:R:I216	R:R:S215	1.55	No	No	0	6	3
281	R:R:I27	R:R:V31	1.54	No	No	0	6	6
282	R:R:I146	R:R:V147	1.54	No	No	0	7	4
283	R:R:I169	R:R:V167	1.54	Yes	No	0	1	1
284	R:R:I203	R:R:V207	1.54	No	No	0	4	4
285	R:R:H129	R:R:P130	1.53	No	No	0	6	8
286	R:R:I203	R:R:T199	1.52	No	No	0	4	3
287	R:R:K90	R:R:T174	1.5	No	No	0	4	5
288	R:R:K99	R:R:T165	1.5	No	No	0	7	4
289	R:R:G184	R:R:R190	1.5	No	Yes	0	3	5
290	R:R:G202	R:R:R201	1.5	No	Yes	1	4	5
291	R:R:G202	R:R:R205	1.5	No	Yes	1	4	5
292	R:R:G306	R:R:R238	1.5	No	Yes	0	8	7
293	R:R:L141	R:R:T138	1.47	No	No	0	3	6
294	R:R:G275	R:R:Y274	1.45	No	No	0	1	5
295	R:R:K227	R:R:K230	1.44	Yes	No	0	5	4
296	R:R:I48	R:R:L65	1.43	No	No	0	7	5
297	R:R:I204	R:R:L156	1.43	No	No	0	4	5
298	R:R:I195	R:R:L272	1.43	No	No	0	1	3
299	R:R:A153	R:R:F110	1.39	No	Yes	0	8	7
300	R:R:E270	R:R:K269	1.35	No	No	0	2	4
301	R:R:R241	R:R:S237	1.32	No	No	0	5	4
302	R:R:F37	R:R:V38	1.31	Yes	No	0	6	5
303	R:R:R190	R:R:V193	1.31	Yes	No	0	5	4
304	R:R:D308	R:R:Q307	1.31	No	No	0	6	5
305	R:R:E311	R:R:H315	1.23	No	No	0	4	4
306	R:R:Q307	R:R:R238	1.17	No	Yes	0	5	7
307	R:R:E270	R:R:Y274	1.12	No	No	0	2	5
308	R:R:F53	R:R:R54	1.07	No	Yes	0	4	4
309	R:R:R238	R:R:R310	1.07	Yes	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L33	5.6025	4	0	7
2	R:R:F37	5.36	4	0	6
3	R:R:N44	7.975	4	0	9
4	R:R:R54	5.6675	4	0	4
5	R:R:Y64	7.2225	4	1	8
6	R:R:N66	7.2925	4	0	9
7	R:R:F74	6.76	4	1	7
8	R:R:W91	9.3025	4	0	9
9	R:R:F93	9.19	4	0	7
10	R:R:I101	6.635	4	0	5
11	R:R:L109	5.6825	4	1	8
12	R:R:F110	9.915	4	0	7
13	R:R:I119	3.92	5	1	9
14	R:R:R123	6.91	4	1	9
15	R:R:R137	9.2825	4	0	7
16	R:R:I169	3.402	5	4	1
17	R:R:F178	4.265	6	1	4
18	R:R:F180	5.8275	4	0	6
19	R:R:R190	4.6425	4	0	5
20	R:R:R201	4.81571	7	1	5
21	R:R:R205	8.09167	6	1	5
22	R:R:F206	7.3	4	1	6
23	R:R:F210	8.3375	4	1	9
24	R:R:M214	6.9325	4	0	6
25	R:R:Y221	5.09667	6	0	8
26	R:R:K227	2.895	4	0	5
27	R:R:I234	4.005	4	0	4
28	R:R:R238	1.655	4	0	7
29	R:R:V246	5.475	4	0	8
30	R:R:F250	6.648	5	1	9
31	R:R:W254	6.614	5	1	9
32	R:R:F255	7.16	4	0	6
33	R:R:N285	6.825	4	3	4
34	R:R:F292	5.88	5	1	7
35	R:R:N294	7.392	5	1	9
36	R:R:Y302	6.478	5	1	9
37	R:R:F309	7.106	5	1	8
38	L:L:W4	4.2075	4	1	0
39	L:L:Y6	5.988	5	1	0
40	L:L:?9	11.79	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N285	R:R:V284	10.6797	4.43	Yes	No	3	4	5
2	L:L:M7	R:R:V284	25.4591	4.56	No	No	0	0	5
3	L:L:M7	R:R:R205	26.7542	7.44	No	Yes	0	0	5
4	L:L:?9	R:R:R205	26.0901	23.43	Yes	Yes	1	0	5
5	L:L:?9	R:R:L109	89.1977	3.64	Yes	Yes	1	0	8
6	R:R:F292	R:R:L109	14.2022	7.31	Yes	Yes	1	7	8
7	R:R:F292	R:R:L33	12.6133	3.65	Yes	Yes	0	7	7
8	R:R:N294	R:R:W254	49.4444	9.04	Yes	Yes	1	9	9
9	R:R:L109	R:R:W254	100	5.69	Yes	Yes	1	8	9
10	R:R:D71	R:R:N44	15.5636	16.16	No	Yes	0	9	9
11	R:R:D71	R:R:S295	15.8599	5.89	No	No	0	9	9
12	R:R:F74	R:R:S295	16.5981	6.61	Yes	No	0	7	9
13	R:R:F74	R:R:L109	45.6282	6.09	Yes	Yes	1	7	8
14	R:R:N44	R:R:P299	12.7283	6.52	Yes	No	0	9	9
15	R:R:P299	R:R:V47	12.5495	5.3	No	No	0	9	9
16	R:R:Q258	R:R:R205	12.9275	7.01	No	Yes	1	8	5
17	R:R:F210	R:R:Q258	11.7857	10.54	Yes	No	1	9	8
18	R:R:F210	R:R:M214	14.1357	9.95	Yes	Yes	0	9	6
19	R:R:F250	R:R:M214	18.9532	7.46	Yes	Yes	0	9	6
20	R:R:F250	R:R:I116	65.5777	8.79	Yes	No	1	9	8
21	R:R:I116	R:R:Y302	65.2507	8.46	No	Yes	1	8	9
22	R:R:I119	R:R:Y302	35.6995	4.84	Yes	Yes	1	9	9
23	R:R:I119	R:R:Y64	17.3644	3.63	Yes	Yes	1	9	8
24	R:R:V303	R:R:Y64	14.7207	13.88	No	Yes	1	7	8
25	R:R:F250	R:R:W254	48.5198	7.02	Yes	Yes	1	9	9
26	R:R:N294	R:R:N298	48.6577	9.54	Yes	No	1	9	9
27	R:R:N298	R:R:Y302	48.4763	5.81	No	Yes	1	9	9
28	R:R:R123	R:R:Y302	44.9284	8.23	Yes	Yes	1	9	9
29	R:R:R123	R:R:Y64	18.9583	5.14	Yes	Yes	1	9	8
30	R:R:F309	R:R:V50	12.2736	6.55	Yes	No	0	8	7
31	R:R:V50	R:R:W49	11.3975	3.68	No	No	0	7	4
32	R:R:T60	R:R:Y64	23.4489	6.24	No	Yes	0	7	8
33	R:R:R137	R:R:T60	21.0938	3.88	Yes	No	0	7	7
34	R:R:R137	R:R:V59	11.9364	14.38	Yes	No	0	7	6
35	R:R:L115	R:R:L67	20.8843	4.15	No	No	0	8	9
36	R:R:I119	R:R:L67	22.067	2.85	Yes	No	0	9	9
37	R:R:L115	R:R:N66	17.3057	5.49	No	Yes	0	8	9
38	R:R:I146	R:R:N66	11.2391	8.5	No	Yes	0	7	9
39	R:R:F74	R:R:N108	39.5157	3.62	Yes	No	0	7	8
40	R:R:I101	R:R:T77	32.2741	7.6	Yes	No	0	5	7
41	R:R:T77	R:R:V104	34.3687	4.76	No	No	0	7	5
42	R:R:N108	R:R:V104	37.4722	4.43	No	No	0	8	5
43	R:R:I101	R:R:W91	16.8817	5.87	Yes	Yes	0	5	9
44	R:R:F93	R:R:P92	13.5533	5.78	Yes	No	0	7	3
45	L:L:K5	R:R:E89	12.4345	8.1	No	No	0	0	4
46	R:R:E89	R:R:Y175	11.2366	4.49	No	No	0	4	3
47	R:R:I103	R:R:V160	10.1254	4.61	No	No	0	5	4
48	L:L:?9	R:R:F110	11.5431	18.15	Yes	Yes	0	0	7
49	R:R:P213	R:R:V113	12.1178	3.53	No	No	0	9	7
50	R:R:R123	R:R:Y221	34.1873	9.26	Yes	Yes	0	9	8
51	R:R:V246	R:R:Y221	29.7658	6.31	Yes	Yes	0	8	8
52	R:R:V246	R:R:Y302	35.1605	5.05	Yes	Yes	0	8	9
53	R:R:K227	R:R:L128	11.377	4.23	Yes	No	0	5	7
54	R:R:K227	R:R:V127	43.9781	3.04	Yes	No	0	5	8
55	R:R:I224	R:R:V127	46.1749	9.22	No	No	0	8	8
56	R:R:I224	R:R:Y221	48.3563	3.63	No	Yes	0	8	8
57	R:R:L212	R:R:P213	10.3093	4.93	No	No	0	5	9
58	R:R:F178	R:R:R201	39.5821	4.28	Yes	Yes	1	4	5
59	R:R:F178	R:R:F180	12.8049	3.22	Yes	Yes	0	4	6
60	L:L:W4	R:R:F178	22.6315	4.01	Yes	Yes	1	0	4
61	R:R:I195	R:R:K269	11.2314	2.91	No	No	0	1	4
62	R:R:I195	R:R:L272	14.5036	1.43	No	No	0	1	3
63	R:R:L268	R:R:L272	15.5866	6.92	No	No	0	3	3
64	R:R:L198	R:R:L268	16.6594	4.15	No	No	0	4	3
65	L:L:W4	R:R:L198	17.7042	5.69	Yes	No	0	0	4
66	R:R:I228	R:R:I234	21.8269	2.94	No	Yes	0	8	4
67	R:R:I228	R:R:M233	24.0645	2.92	No	No	0	8	3
68	R:R:K231	R:R:M233	26.297	5.76	No	No	0	5	3
69	R:R:K227	R:R:K231	28.5244	2.87	Yes	No	0	5	5
70	R:R:I234	R:R:P239	15.0834	3.39	Yes	No	0	4	7
71	R:R:P239	R:R:R238	10.5622	2.88	No	Yes	0	7	7
72	L:L:K5	R:R:V284	13.4435	4.55	No	No	3	0	5
73	L:L:?9	R:R:R201	49.8889	9.59	Yes	Yes	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F74	R:R:L109	6.09	1	Yes	Yes	7	8	2	1
R:R:F292	R:R:F74	10.72	1	Yes	Yes	7	7	2	2
R:R:M85	R:R:N285	11.22	0	No	Yes	6	4	2	1
R:R:E89	R:R:Y175	4.49	0	No	No	4	3	1	2
L:L:K5	R:R:E89	8.1	3	No	No	0	4	0	1
R:R:H102	R:R:L164	9	1	No	No	6	5	1	1
L:L:Y6	R:R:H102	8.71	1	Yes	No	0	6	0	1
R:R:D106	R:R:V160	7.3	0	No	No	5	4	1	2
L:L:?9	R:R:D106	10.71	1	Yes	No	0	5	0	1
R:R:L109	R:R:W254	5.69	1	Yes	Yes	8	9	1	2
R:R:F292	R:R:L109	7.31	1	Yes	Yes	7	8	2	1
L:L:?9	R:R:L109	3.64	1	Yes	Yes	0	8	0	1
R:R:F110	R:R:F114	4.29	0	Yes	No	7	6	1	2
R:R:F110	R:R:L156	15.83	0	Yes	No	7	5	1	2
L:L:?9	R:R:F110	18.15	1	Yes	Yes	0	7	0	1
R:R:R201	R:R:V160	3.92	1	Yes	No	5	4	1	2
L:L:Y6	R:R:L164	4.69	1	Yes	No	0	5	0	1
R:R:F178	R:R:T177	5.19	1	Yes	No	4	3	1	1
L:L:W4	R:R:T177	3.64	1	Yes	No	0	3	0	1
L:L:Y6	R:R:T177	6.24	1	Yes	No	0	3	0	1
R:R:F178	R:R:M197	3.73	1	Yes	No	4	1	1	2
R:R:F178	R:R:R201	4.28	1	Yes	Yes	4	5	1	1
L:L:W4	R:R:F178	4.01	1	Yes	Yes	0	4	0	1
L:L:Y6	R:R:F178	5.16	1	Yes	Yes	0	4	0	1
R:R:L198	R:R:L268	4.15	0	No	No	4	3	1	2
L:L:W4	R:R:L198	5.69	1	Yes	No	0	4	0	1
R:R:R201	R:R:R205	6.4	1	Yes	Yes	5	5	1	1
L:L:Y6	R:R:R201	5.14	1	Yes	Yes	0	5	0	1
L:L:?9	R:R:R201	9.59	1	Yes	Yes	0	5	0	1
R:R:Q258	R:R:R205	7.01	1	No	Yes	8	5	2	1
L:L:M7	R:R:R205	7.44	0	No	Yes	0	5	0	1
L:L:?9	R:R:R205	23.43	1	Yes	Yes	0	5	0	1
R:R:D281	R:R:M271	4.16	0	No	No	4	1	2	1
R:R:N285	R:R:V284	4.43	3	Yes	No	4	5	1	1
L:L:K5	R:R:V284	4.55	3	No	No	0	5	0	1
L:L:M7	R:R:V284	4.56	0	No	No	0	5	0	1
L:L:K5	R:R:N285	8.39	3	No	Yes	0	4	0	1
L:L:W4	R:R:M271	3.49	1	Yes	No	0	1	0	1
R:R:N285	R:R:P29	3.26	3	Yes	No	4	5	1	2
R:R:F178	R:R:F180	3.22	1	Yes	Yes	4	6	1	2
R:R:P159	R:R:R201	2.88	0	No	Yes	8	5	2	1
R:R:A261	R:R:R205	2.77	0	No	Yes	5	5	2	1
R:R:G264	R:R:M271	1.75	0	No	No	4	1	2	1
R:R:G202	R:R:R201	1.5	1	No	Yes	4	5	2	1
R:R:G202	R:R:R205	1.5	1	No	Yes	4	5	2	1
R:R:A153	R:R:F110	1.39	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OMM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	286
Number of Links	309
Number of Hubs	40
Number of Links mediated by Hubs	147
Number of Communities	4
Number of Nodes involved in Communities	38
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	76207
Length Of Smallest Path	3
Average Path Length	14.4822
Length of Longest Path	31
Minimum Path Strength	1.18333
Average Path Strength	6.24097
Maximum Path Strength	20.79
Minimum Path Correlation	0.7
Average Path Correlation	0.92827
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.4139
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.1309
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • amide binding • amyloid-beta binding • binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • protein binding • signaling receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • negative regulation of biological process • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • response to chemical • locomotion • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of transport • regulation of phagocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • biological process involved in interspecies interaction between organisms • response to other organism • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to bacterium • response to external biotic stimulus • multicellular organismal process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • anatomical structure development • system development • developmental process • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell migration • cell motility • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • cellular response to chemical stimulus • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell adhesion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • positive regulation of defense response • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule membrane • specific granule • cell periphery • plasma membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	QXV
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	QXV
Name	D-methioninamide
Synonyms
Identifier
Formula	C5 H12 N2 O S
Molecular Weight	148.227
SMILES
PubChem	11571827
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>6OMM_nogp_Chain_R G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	To be published
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	To be published
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	To be published
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	To be published
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	10.1038/s41467-022-29361-x
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	10.1038/s41467-022-29361-x
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	10.1038/s41467-022-28586-0
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-	Gi1/β1/γ2	3	2022-03-30	10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-		3	2022-03-30	10.1038/s41467-022-28586-0
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	10.1038/s41467-020-15009-1
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	10.1038/s41467-020-14728-9

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