psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	9.84	Yes	Yes	1	0	5
2	L:L:?1	R:R:L109	6.28	Yes	No	0	0	8
3	L:L:?1	R:R:F110	19.88	Yes	Yes	1	0	7
4	L:L:?1	R:R:R201	14.32	Yes	No	1	0	5
5	L:L:?1	R:R:R205	25.34	Yes	Yes	1	0	5
6	L:L:?1	R:R:W254	6.2	Yes	Yes	1	0	9
7	L:L:?1	R:R:F257	4.42	Yes	Yes	0	0	7
8	L:L:?1	R:R:Q258	3.62	Yes	Yes	1	0	8
9	L:L:P3	R:R:F257	8.67	No	Yes	0	0	7
10	L:L:P3	R:R:V284	3.53	No	No	0	0	5
11	L:L:R4	L:L:S7	3.95	No	No	0	0	0
12	L:L:R4	R:R:L268	4.86	No	No	0	0	3
13	L:L:G5	R:R:E89	4.91	No	Yes	0	0	4
14	L:L:F6	R:R:E89	15.16	No	Yes	0	0	4
15	L:L:F6	R:R:Y175	7.22	No	No	0	0	3
16	L:L:L12	L:L:S7	6.01	No	No	0	0	0
17	L:L:C8	R:R:L272	4.76	No	No	0	0	3
18	L:L:L11	L:L:S14	4.5	Yes	No	0	0	0
19	L:L:L11	R:R:I169	4.28	Yes	Yes	0	0	1
20	L:L:L11	R:R:Y175	3.52	Yes	No	0	0	3
21	L:L:L12	R:R:F180	4.87	No	Yes	0	0	6
22	L:L:T13	R:R:R190	5.17	No	No	0	0	5
23	R:R:S19	R:R:Y22	6.36	No	No	0	4	2
24	R:R:I282	R:R:Y22	4.84	No	No	0	2	2
25	R:R:L28	R:R:P29	3.28	No	No	0	5	5
26	R:R:S289	R:R:V32	6.46	No	Yes	0	5	5
27	R:R:I82	R:R:L33	5.71	No	No	0	7	7
28	R:R:F292	R:R:L33	4.87	Yes	No	0	7	7
29	R:R:F293	R:R:T36	3.89	No	No	6	5	7
30	R:R:C296	R:R:T36	6.76	No	No	6	8	7
31	R:R:F37	R:R:V41	5.24	Yes	No	0	6	6
32	R:R:F37	R:R:L78	3.65	Yes	No	0	6	8
33	R:R:F37	R:R:P79	10.11	Yes	No	0	6	8
34	R:R:G40	R:R:T75	5.46	No	No	0	8	7
35	R:R:F72	R:R:V41	3.93	No	No	0	7	6
36	R:R:T75	R:R:V41	4.76	No	No	0	7	6
37	R:R:D71	R:R:N44	6.73	Yes	No	7	9	9
38	R:R:F72	R:R:N44	6.04	No	No	0	7	9
39	R:R:N44	R:R:P299	8.15	No	No	7	9	9
40	R:R:A68	R:R:V47	3.39	No	No	0	8	9
41	R:R:V303	R:R:V47	11.22	No	No	8	7	9
42	R:R:F309	R:R:V47	9.18	Yes	No	8	8	9
43	R:R:I48	R:R:L69	5.71	No	No	0	7	6
44	R:R:S316	R:R:W49	3.71	No	No	0	5	4
45	R:R:F309	R:R:V50	10.49	Yes	No	0	8	7
46	R:R:G52	R:R:R57	4.5	No	No	0	4	6
47	R:R:R312	R:R:R54	11.73	Yes	No	9	5	4
48	R:R:H315	R:R:R54	4.51	No	No	9	4	4
49	R:R:R54	R:R:S316	9.22	No	No	0	4	5
50	R:R:F309	R:R:M55	3.73	Yes	No	0	8	5
51	R:R:I62	R:R:R57	3.76	No	No	0	7	6
52	R:R:L65	R:R:R57	3.64	No	No	0	5	6
53	R:R:T58	R:R:T61	7.85	No	No	0	7	7
54	R:R:R137	R:R:V59	18.31	Yes	No	0	7	6
55	R:R:A142	R:R:V59	5.09	No	No	0	7	6
56	R:R:R137	R:R:T60	3.88	Yes	No	0	7	7
57	R:R:C63	R:R:I119	4.91	No	No	0	7	9
58	R:R:R123	R:R:Y64	5.14	Yes	No	0	9	8
59	R:R:V303	R:R:Y64	6.31	No	No	0	7	8
60	R:R:L115	R:R:N66	4.12	No	No	0	8	9
61	R:R:I146	R:R:N66	5.66	No	No	0	7	9
62	R:R:N66	R:R:W150	5.65	No	No	0	9	9
63	R:R:L67	R:R:S112	4.5	No	No	0	9	9
64	R:R:L115	R:R:L67	4.15	No	No	0	8	9
65	R:R:L67	R:R:Y302	3.52	No	Yes	0	9	9
66	R:R:D71	R:R:S112	5.89	Yes	No	0	9	9
67	R:R:D71	R:R:N298	5.39	Yes	No	0	9	9
68	R:R:D71	R:R:P299	4.83	Yes	No	7	9	9
69	R:R:N108	R:R:S73	7.45	No	No	0	8	7
70	R:R:F74	R:R:T75	5.19	Yes	No	0	7	7
71	R:R:F74	R:R:L78	8.53	Yes	No	5	7	8
72	R:R:F292	R:R:F74	15	Yes	Yes	5	7	7
73	R:R:F74	R:R:S295	5.28	Yes	No	0	7	9
74	R:R:I101	R:R:T77	6.08	Yes	No	0	5	7
75	R:R:T77	R:R:V104	4.76	No	No	0	7	5
76	R:R:F292	R:R:L78	3.65	Yes	No	5	7	8
77	R:R:F80	R:R:L97	6.09	No	No	2	6	7
78	R:R:F80	R:R:I101	13.82	No	Yes	2	6	5
79	R:R:L81	R:R:V105	4.47	No	No	0	6	6
80	R:R:S84	R:R:W91	6.18	No	Yes	0	5	9
81	R:R:K90	R:R:M87	5.76	No	No	0	4	4
82	R:R:D173	R:R:K90	12.44	No	No	0	3	4
83	R:R:K90	R:R:Y175	14.33	No	No	0	4	3
84	R:R:F93	R:R:W91	20.04	Yes	Yes	0	7	9
85	R:R:C98	R:R:W91	14.37	Yes	Yes	2	9	9
86	R:R:I101	R:R:W91	7.05	Yes	Yes	2	5	9
87	R:R:C176	R:R:W91	7.84	No	Yes	2	9	9
88	R:R:F93	R:R:L97	7.31	Yes	No	0	7	7
89	R:R:K99	R:R:W95	17.4	No	No	0	7	4
90	R:R:T166	R:R:W95	7.28	Yes	No	0	5	4
91	R:R:I101	R:R:L97	4.28	Yes	No	2	5	7
92	R:R:C98	R:R:H102	4.42	Yes	No	0	9	6
93	R:R:C98	R:R:T166	3.38	Yes	Yes	2	9	5
94	R:R:C176	R:R:C98	7.28	No	Yes	2	9	9
95	R:R:K99	R:R:T165	6.01	No	No	0	7	4
96	R:R:H102	R:R:L164	9	No	No	0	6	5
97	R:R:F161	R:R:I103	11.3	No	No	0	4	5
98	R:R:N108	R:R:V104	4.43	No	No	0	8	5
99	R:R:D106	R:R:F110	8.36	Yes	Yes	1	5	7
100	R:R:D106	R:R:T157	11.56	Yes	Yes	1	5	7
101	R:R:D106	R:R:V160	5.84	Yes	No	1	5	4
102	R:R:I107	R:R:L154	5.71	No	No	0	5	4
103	R:R:I107	R:R:T157	10.64	No	Yes	0	5	7
104	R:R:F110	R:R:F114	8.57	Yes	Yes	1	7	6
105	R:R:F110	R:R:L156	9.74	Yes	No	1	7	5
106	R:R:F114	R:R:V113	3.93	Yes	No	0	6	7
107	R:R:P213	R:R:V113	5.3	No	No	0	9	7
108	R:R:F114	R:R:P149	5.78	Yes	No	0	6	7
109	R:R:F114	R:R:L152	9.74	Yes	No	0	6	4
110	R:R:G117	R:R:I116	3.53	No	Yes	0	7	8
111	R:R:F250	R:R:I116	7.54	No	Yes	0	9	8
112	R:R:I116	R:R:N298	8.5	Yes	No	0	8	9
113	R:R:I116	R:R:Y302	9.67	Yes	Yes	0	8	9
114	R:R:F118	R:R:V145	6.55	No	No	0	7	5
115	R:R:F118	R:R:I146	6.28	No	No	0	7	7
116	R:R:I119	R:R:R123	7.52	No	Yes	4	9	9
117	R:R:I119	R:R:Y302	6.04	No	Yes	4	9	9
118	R:R:A120	R:R:C220	3.61	No	No	0	9	7
119	R:R:A120	R:R:Y221	5.34	No	Yes	0	9	8
120	R:R:I216	R:R:L121	8.56	No	No	0	6	7
121	R:R:C126	R:R:D122	4.67	No	No	10	8	8
122	R:R:D122	R:R:R137	11.91	No	Yes	10	8	7
123	R:R:R123	R:R:Y221	11.32	Yes	Yes	4	9	8
124	R:R:R123	R:R:Y302	8.23	Yes	Yes	4	9	9
125	R:R:C124	R:R:C220	7.28	No	No	0	8	7
126	R:R:C124	R:R:L223	4.76	No	No	0	8	3
127	R:R:A133	R:R:C126	3.61	No	No	0	5	8
128	R:R:C126	R:R:R137	5.57	No	Yes	10	8	7
129	R:R:I224	R:R:V127	10.75	No	No	0	8	8
130	R:R:K227	R:R:V127	6.07	No	No	0	5	8
131	R:R:L128	R:R:L223	6.92	No	No	0	7	3
132	R:R:K227	R:R:P130	3.35	No	No	0	5	8
133	R:R:H136	R:R:W132	21.16	No	No	0	3	5
134	R:R:N135	R:R:Q134	3.96	No	No	0	4	5
135	R:R:L141	R:R:T138	4.42	No	No	0	3	6
136	R:R:K144	R:R:S140	4.59	No	No	0	1	4
137	R:R:G148	R:R:P149	4.06	No	No	0	3	7
138	R:R:G148	R:R:I151	3.53	No	No	0	3	3
139	R:R:I204	R:R:L156	4.28	No	No	1	4	5
140	R:R:I208	R:R:L156	5.71	No	No	1	5	5
141	R:R:T157	R:R:V160	4.76	Yes	No	1	7	4
142	R:R:F161	R:R:T157	6.49	No	Yes	0	4	7
143	R:R:L158	R:R:P159	3.28	No	No	0	4	8
144	R:R:F161	R:R:L158	4.87	No	No	0	4	4
145	R:R:F163	R:R:L162	7.31	Yes	No	3	5	5
146	R:R:L162	R:R:W183	4.56	No	Yes	3	5	4
147	R:R:F163	R:R:F180	9.65	Yes	Yes	3	5	6
148	R:R:F163	R:R:W183	16.04	Yes	Yes	3	5	4
149	R:R:F163	R:R:M197	4.98	Yes	No	3	5	1
150	R:R:F178	R:R:L164	7.31	No	No	0	4	5
151	R:R:N179	R:R:T165	4.39	No	No	0	3	4
152	R:R:C176	R:R:T166	6.76	No	Yes	2	9	5
153	R:R:N179	R:R:V167	5.91	No	No	0	3	1
154	R:R:I169	R:R:P170	3.39	Yes	No	0	1	3
155	R:R:I169	R:R:N171	7.08	Yes	No	0	1	4
156	R:R:D173	R:R:I169	5.6	No	Yes	0	3	1
157	R:R:F178	R:R:M197	6.22	No	No	0	4	1
158	R:R:F178	R:R:R201	8.55	No	No	0	4	5
159	R:R:A181	R:R:N179	4.69	No	No	0	5	3
160	R:R:F180	R:R:V193	10.49	Yes	No	0	6	4
161	R:R:A194	R:R:F180	5.55	No	Yes	0	3	6
162	R:R:F180	R:R:M197	8.71	Yes	No	3	6	1
163	R:R:E189	R:R:G184	8.19	No	No	0	3	3
164	R:R:G185	R:R:R190	4.5	No	No	0	3	5
165	R:R:P187	R:R:T186	5.25	No	No	0	5	6
166	R:R:E189	R:R:T186	7.06	No	No	0	3	6
167	R:R:E188	R:R:P187	11	No	No	0	3	5
168	R:R:P187	R:R:R190	4.32	No	No	0	5	5
169	R:R:F273	R:R:L191	6.09	No	No	0	5	1
170	R:R:K192	R:R:T196	6.01	No	No	0	5	1
171	R:R:I195	R:R:K269	5.82	No	No	0	1	4
172	R:R:L198	R:R:L268	6.92	No	No	0	4	3
173	R:R:R201	R:R:R205	5.33	No	Yes	1	5	5
174	R:R:G202	R:R:T265	5.46	No	No	0	4	4
175	R:R:I204	R:R:I208	4.42	No	No	1	4	5
176	R:R:Q258	R:R:R205	8.18	Yes	Yes	1	8	5
177	R:R:A261	R:R:R205	5.53	No	Yes	0	5	5
178	R:R:F206	R:R:F210	5.36	No	Yes	0	6	9
179	R:R:F206	R:R:L211	6.09	No	No	0	6	4
180	R:R:F206	R:R:L262	19.49	No	No	0	6	5
181	R:R:G209	R:R:P213	4.06	No	No	0	6	9
182	R:R:F210	R:R:M214	7.46	Yes	No	0	9	6
183	R:R:F210	R:R:F255	8.57	Yes	Yes	0	9	6
184	R:R:F210	R:R:Q258	18.74	Yes	Yes	0	9	8
185	R:R:L212	R:R:P213	4.93	No	No	0	5	9
186	R:R:I216	R:R:L212	4.28	No	No	0	6	5
187	R:R:F250	R:R:M214	4.98	No	No	0	9	6
188	R:R:F251	R:R:M214	3.73	No	No	0	6	6
189	R:R:V217	R:R:Y221	7.57	No	Yes	0	8	8
190	R:R:L243	R:R:Y221	10.55	No	Yes	0	8	8
191	R:R:V247	R:R:Y221	3.79	No	Yes	0	8	8
192	R:R:Y221	R:R:Y302	4.96	Yes	Yes	4	8	9
193	R:R:I228	R:R:I234	8.83	No	No	0	8	4
194	R:R:I234	R:R:L240	4.28	No	No	0	4	5
195	R:R:R241	R:R:S237	9.22	No	No	0	5	4
196	R:R:V242	R:R:V305	4.81	No	No	0	8	7
197	R:R:L301	R:R:V246	4.47	No	No	0	8	8
198	R:R:V246	R:R:Y302	3.79	No	Yes	0	8	9
199	R:R:L297	R:R:S249	6.01	No	No	0	6	7
200	R:R:F250	R:R:W254	11.02	No	Yes	0	9	9
201	R:R:F251	R:R:F255	15	No	Yes	0	6	6
202	R:R:C253	R:R:L290	4.76	No	No	0	8	8
203	R:R:C253	R:R:N294	6.3	No	Yes	0	8	9
204	R:R:Q258	R:R:W254	5.48	Yes	Yes	1	8	9
205	R:R:A291	R:R:W254	7.78	No	Yes	0	8	9
206	R:R:N294	R:R:W254	7.91	Yes	Yes	0	9	9
207	R:R:F255	R:R:P256	4.33	Yes	No	0	6	9
208	R:R:F255	R:R:L259	7.31	Yes	No	0	6	5
209	R:R:F257	R:R:T287	7.78	Yes	No	0	7	7
210	R:R:A291	R:R:F257	4.16	No	Yes	0	8	7
211	R:R:L259	R:R:L263	4.15	No	No	0	5	5
212	R:R:L263	R:R:W267	9.11	No	No	0	5	3
213	R:R:G264	R:R:I280	3.53	No	No	0	4	4
214	R:R:V266	R:R:W267	7.36	No	No	0	4	3
215	R:R:W267	R:R:Y277	38.58	No	No	0	3	3
216	R:R:L268	R:R:L272	4.15	No	No	0	3	3
217	R:R:F273	R:R:K269	7.44	No	No	0	5	4
218	R:R:K276	R:R:Y277	14.33	No	No	0	1	3
219	R:R:F292	R:R:S288	3.96	Yes	No	0	7	6
220	R:R:C296	R:R:F293	5.59	No	No	6	8	5
221	R:R:F293	R:R:L297	3.65	No	No	0	5	6
222	R:R:L297	R:R:N294	4.12	No	Yes	0	6	9
223	R:R:N294	R:R:N298	8.17	Yes	No	0	9	9
224	R:R:F304	R:R:M300	3.73	No	No	0	7	7
225	R:R:F309	R:R:V303	7.87	Yes	No	8	8	7
226	R:R:F304	R:R:F309	6.43	No	Yes	0	7	8
227	R:R:H315	R:R:R312	4.51	No	Yes	9	4	5
228	R:R:N285	R:R:P29	3.26	No	No	0	4	5
229	R:R:A68	R:R:I48	3.25	No	No	0	8	7
230	R:R:S140	R:R:T138	3.2	No	No	0	4	6
231	R:R:R238	R:R:R241	3.2	No	No	0	7	5
232	R:R:R238	R:R:R310	3.2	No	No	0	7	8
233	R:R:T77	R:R:V105	3.17	No	No	0	7	6
234	R:R:T287	R:R:V260	3.17	No	No	0	7	5
235	R:R:T56	R:R:T58	3.14	No	No	0	6	7
236	R:R:T58	R:R:T60	3.14	No	No	0	7	7
237	R:R:T168	R:R:T174	3.14	No	No	0	2	5
238	R:R:F273	R:R:Y274	3.09	No	No	0	5	5
239	R:R:F72	R:R:G45	3.01	No	No	0	7	4
240	R:R:F53	R:R:G52	3.01	No	No	0	4	4
241	R:R:F96	R:R:W95	3.01	No	No	0	1	4
242	R:R:L28	R:R:V32	2.98	No	Yes	0	5	5
243	R:R:L39	R:R:V35	2.98	No	No	0	5	5
244	R:R:L313	R:R:V50	2.98	No	No	0	6	7
245	R:R:L100	R:R:V104	2.98	No	No	0	5	5
246	R:R:L283	R:R:V260	2.98	No	No	0	6	5
247	R:R:L262	R:R:T265	2.95	No	No	0	5	4
248	R:R:I279	R:R:I282	2.94	No	No	0	3	2
249	R:R:I62	R:R:M143	2.92	No	No	0	7	4
250	R:R:F93	R:R:P92	2.89	Yes	No	0	7	3
251	R:R:P239	R:R:R238	2.88	No	No	0	7	7
252	L:L:?1	L:L:A2	2.86	Yes	No	0	0	0
253	R:R:I282	R:R:L25	2.85	No	No	0	2	3
254	R:R:I224	R:R:L243	2.85	No	No	0	8	8
255	R:R:L33	R:R:M85	2.83	No	No	0	7	6
256	R:R:D281	R:R:I280	2.8	No	No	0	4	4
257	R:R:L65	R:R:L69	2.77	No	No	0	5	6
258	R:R:D281	R:R:M271	2.77	No	No	0	4	1
259	R:R:F37	R:R:V38	2.62	Yes	No	0	6	5
260	R:R:F93	R:R:V83	2.62	Yes	No	0	7	5
261	R:R:A70	R:R:W150	2.59	No	No	0	8	9
262	R:R:H129	R:R:L128	2.57	No	No	0	6	7
263	R:R:H136	R:R:N135	2.55	No	No	0	3	4
264	R:R:M55	R:R:R312	2.48	No	Yes	0	5	5
265	R:R:S182	R:R:W183	2.47	No	Yes	0	7	4
266	R:R:M271	R:R:Y277	2.39	No	No	0	1	3
267	R:R:I125	R:R:W132	2.35	No	No	0	5	5
268	R:R:Q307	R:R:R310	2.34	No	No	0	5	8
269	R:R:E311	R:R:R312	2.33	No	Yes	0	4	5
270	R:R:A20	R:R:G21	1.95	No	No	0	4	4
271	R:R:A51	R:R:G52	1.95	No	No	0	7	4
272	R:R:A153	R:R:G111	1.95	No	No	0	8	7
273	R:R:A225	R:R:G222	1.95	No	No	0	5	3
274	R:R:G172	R:R:T168	1.82	No	No	0	4	2
275	R:R:P239	R:R:S236	1.78	No	No	0	7	6
276	R:R:P286	R:R:S289	1.78	No	No	0	6	5
277	R:R:G34	R:R:I82	1.76	No	No	0	5	7
278	R:R:G40	R:R:L39	1.71	No	No	0	8	5
279	R:R:G43	R:R:L42	1.71	No	No	0	8	4
280	R:R:G43	R:R:L46	1.71	No	No	0	8	6
281	R:R:A51	R:R:T61	1.68	No	No	0	7	7
282	R:R:L25	R:R:P286	1.64	No	No	0	3	6
283	R:R:E89	R:R:G88	1.64	Yes	No	0	4	3
284	R:R:L240	R:R:P239	1.64	No	No	0	5	7
285	R:R:C253	R:R:I252	1.64	No	No	0	8	6
286	R:R:A86	R:R:M87	1.61	No	No	0	4	4
287	R:R:V31	R:R:V32	1.6	No	Yes	0	6	5
288	R:R:V242	R:R:V246	1.6	No	No	0	8	8
289	R:R:T23	R:R:V24	1.59	No	No	0	2	4
290	R:R:T36	R:R:V32	1.59	No	Yes	0	7	5
291	R:R:A86	R:R:L30	1.58	No	No	0	4	5
292	R:R:A225	R:R:L243	1.58	No	No	0	5	8
293	R:R:T166	R:R:T174	1.57	Yes	No	0	5	5
294	R:R:I219	R:R:S215	1.55	No	No	0	3	3
295	R:R:I151	R:R:V147	1.54	No	No	0	3	4
296	R:R:I151	R:R:V155	1.54	No	No	0	3	4
297	R:R:I203	R:R:V207	1.54	No	No	0	4	4
298	R:R:I208	R:R:V207	1.54	No	No	0	5	4
299	R:R:I27	R:R:T23	1.52	No	No	0	6	2
300	R:R:M143	R:R:V139	1.52	No	No	0	4	3
301	R:R:I195	R:R:T199	1.52	No	No	0	1	3
302	R:R:I203	R:R:T199	1.52	No	No	0	4	3
303	L:L:E15	R:R:A181	1.51	No	No	0	0	5
304	R:R:F304	R:R:G43	1.51	No	No	0	7	8
305	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
306	R:R:F110	R:R:G111	1.51	Yes	No	1	7	7
307	R:R:F114	R:R:G111	1.51	Yes	No	1	6	7
308	R:R:G88	R:R:R26	1.5	No	No	0	3	4
309	R:R:G306	R:R:R310	1.5	No	No	0	8	8
310	L:L:L11	R:R:V167	1.49	Yes	No	0	0	1
311	R:R:L141	R:R:V145	1.49	No	No	0	3	5
312	R:R:N135	R:R:V131	1.48	No	No	0	4	5
313	L:L:L10	L:L:T13	1.47	No	No	0	0	0
314	R:R:I224	R:R:I228	1.47	No	No	0	8	8
315	R:R:I219	R:R:L223	1.43	No	No	0	3	3
316	R:R:E89	R:R:T177	1.41	Yes	No	0	4	3
317	R:R:G184	R:R:W183	1.41	No	Yes	0	3	4
318	L:L:L11	L:L:L9	1.38	Yes	No	0	0	0
319	R:R:E270	R:R:K269	1.35	No	No	0	2	4
320	R:R:H229	R:R:I234	1.33	No	No	0	3	4
321	R:R:D308	R:R:Q307	1.31	No	No	0	6	5
322	R:R:H129	R:R:W132	1.06	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.3067	9	1	0
2	L:L:L11	3.034	5	0	0
3	R:R:V32	3.1575	4	0	5
4	R:R:F37	5.405	4	0	6
5	R:R:D71	5.71	4	7	9
6	R:R:F74	8.5	4	5	7
7	R:R:E89	5.78	4	0	4
8	R:R:W91	11.096	5	2	9
9	R:R:F93	6.874	5	0	7
10	R:R:C98	7.3625	4	2	9
11	R:R:I101	7.8075	4	2	5
12	R:R:D106	8.9	4	1	5
13	R:R:F110	9.612	5	1	7
14	R:R:F114	5.906	5	1	6
15	R:R:I116	7.31	4	0	8
16	R:R:R123	8.0525	4	4	9
17	R:R:R137	9.9175	4	10	7
18	R:R:T157	8.3625	4	1	7
19	R:R:F163	9.495	4	3	5
20	R:R:T166	4.7475	4	2	5
21	R:R:I169	5.0875	4	0	1
22	R:R:F180	7.854	5	3	6
23	R:R:W183	6.12	4	3	4
24	R:R:R205	11.095	4	1	5
25	R:R:F210	10.0325	4	0	9
26	R:R:Y221	7.255	6	4	8
27	R:R:W254	7.678	5	1	9
28	R:R:F255	8.8025	4	0	6
29	R:R:F257	6.2575	4	0	7
30	R:R:Q258	9.005	4	1	8
31	R:R:F292	6.87	4	5	7
32	R:R:N294	6.625	4	0	9
33	R:R:Y302	6.035	6	4	9
34	R:R:F309	7.54	5	8	8
35	R:R:R312	5.2625	4	9	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R201	82.1666	14.32	Yes	No	1	0	5
2	R:R:F178	R:R:R201	90.2167	8.55	No	No	0	4	5
3	R:R:F178	R:R:M197	34.4343	6.22	No	No	0	4	1
4	R:R:F180	R:R:M197	14.2754	8.71	Yes	No	3	6	1
5	L:L:L12	R:R:F180	10.4718	4.87	No	Yes	0	0	6
6	R:R:F178	R:R:L164	66.6827	7.31	No	No	0	4	5
7	R:R:H102	R:R:L164	65.6042	9	No	No	0	6	5
8	R:R:C98	R:R:H102	64.6028	4.42	Yes	No	0	9	6
9	R:R:C98	R:R:T166	42.1425	3.38	Yes	Yes	2	9	5
10	R:R:T166	R:R:W95	39.2537	7.28	Yes	No	0	5	4
11	R:R:K99	R:R:W95	36.4516	17.4	No	No	0	7	4
12	R:R:K99	R:R:T165	35.0361	6.01	No	No	0	7	4
13	R:R:N179	R:R:T165	33.611	4.39	No	No	0	3	4
14	R:R:N179	R:R:V167	29.2778	5.91	No	No	0	3	1
15	L:L:L11	R:R:V167	27.8045	1.49	Yes	No	0	0	1
16	L:L:L11	R:R:Y175	17.2653	3.52	Yes	No	0	0	3
17	R:R:F163	R:R:M197	18.83	4.98	Yes	No	3	5	1
18	R:R:F163	R:R:W183	16.519	16.04	Yes	Yes	3	5	4
19	R:R:G184	R:R:W183	13.6447	1.41	No	Yes	0	3	4
20	R:R:E189	R:R:G184	12.1666	8.19	No	No	0	3	3
21	R:R:E189	R:R:T186	10.6789	7.06	No	No	0	3	6
22	L:L:?1	R:R:W254	92.0414	6.2	Yes	Yes	1	0	9
23	R:R:N294	R:R:W254	38.0019	7.91	Yes	Yes	0	9	9
24	R:R:L297	R:R:N294	24.5258	4.12	No	Yes	0	6	9
25	R:R:F293	R:R:L297	21.7718	3.65	No	No	0	5	6
26	R:R:F293	R:R:T36	18.9167	3.89	No	No	6	5	7
27	R:R:T36	R:R:V32	17.5686	1.59	No	Yes	0	7	5
28	R:R:S289	R:R:V32	10.3707	6.46	No	Yes	0	5	5
29	R:R:N294	R:R:N298	36.2638	8.17	Yes	No	0	9	9
30	R:R:D71	R:R:N298	41.8681	5.39	Yes	No	0	9	9
31	R:R:D71	R:R:N44	48.9023	6.73	Yes	No	7	9	9
32	R:R:F72	R:R:N44	47.2508	6.04	No	No	0	7	9
33	R:R:F72	R:R:V41	43.6688	3.93	No	No	0	7	6
34	R:R:F37	R:R:V41	19.0708	5.24	Yes	No	0	6	6
35	R:R:F37	R:R:L78	13.3943	3.65	Yes	No	0	6	8
36	R:R:F292	R:R:L78	11.4636	3.65	Yes	No	5	7	8
37	R:R:F292	R:R:L33	15.2672	4.87	Yes	No	0	7	7
38	R:R:T75	R:R:V41	22.9032	4.76	No	No	0	7	6
39	R:R:F74	R:R:T75	15.3539	5.19	Yes	No	0	7	7
40	R:R:F292	R:R:F74	11.5214	15	Yes	Yes	5	7	7
41	R:R:F250	R:R:W254	65.9076	11.02	No	Yes	0	9	9
42	R:R:F250	R:R:I116	84.1839	7.54	No	Yes	0	9	8
43	R:R:I116	R:R:Y302	100	9.67	Yes	Yes	0	8	9
44	R:R:R123	R:R:Y302	51.1074	8.23	Yes	Yes	4	9	9
45	R:R:R123	R:R:Y64	57.3134	5.14	Yes	No	0	9	8
46	R:R:V303	R:R:Y64	56.052	6.31	No	No	0	7	8
47	R:R:V303	R:R:V47	32.6192	11.22	No	No	8	7	9
48	R:R:A68	R:R:V47	32.7395	3.39	No	No	0	8	9
49	R:R:F309	R:R:V303	22.1233	7.87	Yes	No	8	8	7
50	R:R:A68	R:R:I48	31.2759	3.25	No	No	0	8	7
51	R:R:I48	R:R:L69	29.7978	5.71	No	No	0	7	6
52	R:R:F309	R:R:M55	11.4203	3.73	Yes	No	0	8	5
53	R:R:L65	R:R:L69	28.3101	2.77	No	No	0	5	6
54	R:R:L65	R:R:R57	26.8127	3.64	No	No	0	5	6
55	R:R:G52	R:R:R57	20.727	4.5	No	No	0	4	6
56	R:R:A51	R:R:G52	17.6264	1.95	No	No	0	7	4
57	R:R:A51	R:R:T61	16.0616	1.68	No	No	0	7	7
58	R:R:T58	R:R:T61	14.4872	7.85	No	No	0	7	7
59	R:R:T58	R:R:T60	11.3096	3.14	No	No	0	7	7
60	R:R:L67	R:R:Y302	27.7419	3.52	No	Yes	0	9	9
61	R:R:L115	R:R:L67	17.4194	4.15	No	No	0	8	9
62	R:R:L115	R:R:N66	15.8835	4.12	No	No	0	8	9
63	R:R:I146	R:R:N66	11.2181	5.66	No	No	0	7	9
64	R:R:D71	R:R:S112	15.2528	5.89	Yes	No	0	9	9
65	R:R:C98	R:R:W91	25.0409	14.37	Yes	Yes	2	9	9
66	R:R:I101	R:R:W91	16.4709	7.05	Yes	Yes	2	5	9
67	R:R:I101	R:R:T77	11.791	6.08	Yes	No	0	5	7
68	L:L:?1	R:R:D106	11.3962	9.84	Yes	Yes	1	0	5
69	L:L:?1	R:R:F110	35.6187	19.88	Yes	Yes	1	0	7
70	R:R:F110	R:R:F114	17.8527	8.57	Yes	Yes	1	7	6
71	R:R:F110	R:R:L156	16.7501	9.74	Yes	No	1	7	5
72	R:R:Y221	R:R:Y302	47.4868	4.96	Yes	Yes	4	8	9
73	R:R:A120	R:R:Y221	22.5084	5.34	No	Yes	0	9	8
74	R:R:A120	R:R:C220	20.9629	3.61	No	No	0	9	7
75	R:R:C124	R:R:C220	19.4078	7.28	No	No	0	8	7
76	R:R:C124	R:R:L223	17.843	4.76	No	No	0	8	3
77	R:R:L243	R:R:Y221	31.2133	10.55	No	Yes	0	8	8
78	R:R:I224	R:R:L243	26.8512	2.85	No	No	0	8	8
79	R:R:L128	R:R:L223	13.091	6.92	No	No	0	7	3
80	R:R:H129	R:R:L128	11.4877	2.57	No	No	0	6	7
81	R:R:I208	R:R:L156	14.0058	5.71	No	No	1	5	5
82	R:R:I208	R:R:V207	12.6914	1.54	No	No	0	5	4
83	R:R:I203	R:R:V207	11.3192	1.54	No	No	0	4	4
84	L:L:?1	R:R:Q258	13.0236	3.62	Yes	Yes	1	0	8
85	R:R:F210	R:R:Q258	25.1131	18.74	Yes	Yes	0	9	8
86	R:R:F250	R:R:M214	21.4877	4.98	No	No	0	9	6
87	R:R:F210	R:R:M214	13.3317	7.46	Yes	No	0	9	6
88	R:R:F210	R:R:F255	23.7073	8.57	Yes	Yes	0	9	6
89	R:R:I224	R:R:I228	20.8377	1.47	No	No	0	8	8
90	R:R:I228	R:R:I234	19.2826	8.83	No	No	0	8	4
91	R:R:I234	R:R:L240	16.1435	4.28	No	No	0	4	5
92	R:R:L240	R:R:P239	14.5595	1.64	No	No	0	5	7
93	R:R:P239	R:R:R238	11.3625	2.88	No	No	0	7	7
94	R:R:F255	R:R:L259	25.3683	7.31	Yes	No	0	6	5
95	R:R:L259	R:R:L263	22.8743	4.15	No	No	0	5	5
96	R:R:L263	R:R:W267	20.3707	9.11	No	No	0	5	3
97	R:R:W267	R:R:Y277	15.3346	38.58	No	No	0	3	3
98	R:R:M271	R:R:Y277	10.26	2.39	No	No	0	1	3
99	R:R:I116	R:R:N298	26.5864	8.5	Yes	No	0	8	9
100	R:R:L67	R:R:S112	14.7328	4.5	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	9.84	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L109	6.28	1	Yes	No	0	8	0	1
L:L:?1	R:R:F110	19.88	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R201	14.32	1	Yes	No	0	5	0	1
L:L:?1	R:R:R205	25.34	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W254	6.2	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F257	4.42	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q258	3.62	1	Yes	Yes	0	8	0	1
L:L:P3	R:R:F257	8.67	0	No	Yes	0	7	0	1
L:L:P3	R:R:V284	3.53	0	No	No	0	5	0	1
L:L:R4	R:R:L268	4.86	0	No	No	0	3	0	1
L:L:G5	R:R:E89	4.91	0	No	Yes	0	4	0	1
L:L:F6	R:R:E89	15.16	0	No	Yes	0	4	0	1
L:L:F6	R:R:Y175	7.22	0	No	No	0	3	0	1
L:L:C8	R:R:L272	4.76	0	No	No	0	3	0	1
L:L:L11	R:R:I169	4.28	0	Yes	Yes	0	1	0	1
L:L:L11	R:R:Y175	3.52	0	Yes	No	0	3	0	1
L:L:L12	R:R:F180	4.87	0	No	Yes	0	6	0	1
L:L:T13	R:R:R190	5.17	0	No	No	0	5	0	1
R:R:D173	R:R:K90	12.44	0	No	No	3	4	2	2
R:R:K90	R:R:Y175	14.33	0	No	No	4	3	2	1
R:R:D106	R:R:F110	8.36	1	Yes	Yes	5	7	1	1
R:R:D106	R:R:T157	11.56	1	Yes	Yes	5	7	1	2
R:R:D106	R:R:V160	5.84	1	Yes	No	5	4	1	2
R:R:F110	R:R:F114	8.57	1	Yes	Yes	7	6	1	2
R:R:F110	R:R:L156	9.74	1	Yes	No	7	5	1	2
R:R:T157	R:R:V160	4.76	1	Yes	No	7	4	2	2
R:R:F163	R:R:F180	9.65	3	Yes	Yes	5	6	2	1
R:R:F163	R:R:M197	4.98	3	Yes	No	5	1	2	2
R:R:N179	R:R:V167	5.91	0	No	No	3	1	2	1
R:R:I169	R:R:P170	3.39	0	Yes	No	1	3	1	2
R:R:I169	R:R:N171	7.08	0	Yes	No	1	4	1	2
R:R:D173	R:R:I169	5.6	0	No	Yes	3	1	2	1
R:R:F178	R:R:M197	6.22	0	No	No	4	1	2	2
R:R:F178	R:R:R201	8.55	0	No	No	4	5	2	1
R:R:A181	R:R:N179	4.69	0	No	No	5	3	1	2
R:R:F180	R:R:V193	10.49	3	Yes	No	6	4	1	2
R:R:A194	R:R:F180	5.55	0	No	Yes	3	6	2	1
R:R:F180	R:R:M197	8.71	3	Yes	No	6	1	1	2
R:R:G185	R:R:R190	4.5	0	No	No	3	5	2	1
R:R:P187	R:R:R190	4.32	0	No	No	5	5	2	1
R:R:L198	R:R:L268	6.92	0	No	No	4	3	2	1
R:R:R201	R:R:R205	5.33	1	No	Yes	5	5	1	1
R:R:Q258	R:R:R205	8.18	1	Yes	Yes	8	5	1	1
R:R:A261	R:R:R205	5.53	0	No	Yes	5	5	2	1
R:R:F210	R:R:Q258	18.74	0	Yes	Yes	9	8	2	1
R:R:F250	R:R:W254	11.02	0	No	Yes	9	9	2	1
R:R:Q258	R:R:W254	5.48	1	Yes	Yes	8	9	1	1
R:R:A291	R:R:W254	7.78	0	No	Yes	8	9	2	1
R:R:N294	R:R:W254	7.91	0	Yes	Yes	9	9	2	1
R:R:F257	R:R:T287	7.78	0	Yes	No	7	7	1	2
R:R:A291	R:R:F257	4.16	0	No	Yes	8	7	2	1
R:R:L268	R:R:L272	4.15	0	No	No	3	3	1	1
R:R:E89	R:R:G88	1.64	0	Yes	No	4	3	1	2
L:L:E15	R:R:A181	1.51	0	No	No	0	5	0	1
R:R:F110	R:R:G111	1.51	1	Yes	No	7	7	1	2
R:R:F114	R:R:G111	1.51	1	Yes	No	6	7	2	2
L:L:L11	R:R:V167	1.49	0	Yes	No	0	1	0	1
R:R:E89	R:R:T177	1.41	0	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WVX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	298
Number of Links	322
Number of Hubs	35
Number of Links mediated by Hubs	131
Number of Communities	10
Number of Nodes involved in Communities	48
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	52249
Length Of Smallest Path	3
Average Path Length	15.092
Length of Longest Path	39
Minimum Path Strength	1.435
Average Path Strength	6.86157
Maximum Path Strength	26.455
Minimum Path Correlation	0.7
Average Path Correlation	0.93751
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	52.8651
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.6949
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• intracellular iron ion homeostasis • inorganic ion homeostasis • cellular homeostasis • chemical homeostasis • homeostatic process • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • multicellular organismal process • regulation of cellular process • negative regulation of biological process • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of biological process • negative regulation of metabolic process • biological regulation • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • regulation of interleukin-18 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • cellular process • macromolecule metabolic process • negative regulation of interleukin-18 production • negative regulation of multicellular organismal process • regulation of metabolic process • interleukin-18 production • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • cellular response to stimulus • positive regulation of response to biotic stimulus • pattern recognition receptor signaling pathway • response to stimulus • regulation of NLRP3 inflammasome complex assembly • regulation of signal transduction • response to biotic stimulus • intracellular signal transduction • cell communication • cellular component biogenesis • immune response-activating signaling pathway • cellular component assembly • inflammasome-mediated signaling pathway • positive regulation of immune response • canonical inflammasome complex assembly • regulation of immune system process • signal transduction • negative regulation of NLRP3 inflammasome complex assembly • positive regulation of immune system process • innate immune response-activating signaling pathway • negative regulation of cellular component organization • immune response • response to other organism • regulation of innate immune response • response to external stimulus • regulation of inflammasome-mediated signaling pathway • negative regulation of protein-containing complex assembly • regulation of response to stimulus • defense response to other organism • regulation of pattern recognition receptor signaling pathway • NLRP3 inflammasome complex assembly • positive regulation of defense response • activation of innate immune response • regulation of immune response • inflammatory response • activation of immune response • cytoplasmic pattern recognition receptor signaling pathway • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of cellular component organization • regulation of response to external stimulus • intracellular receptor signaling pathway • signaling • negative regulation of signaling • negative regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of intracellular signal transduction • positive regulation of biological process • regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of cell communication • positive regulation of response to stimulus • cellular component organization • regulation of protein-containing complex assembly • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of intracellular signal transduction • regulation of response to stress • response to stress • innate immune response • protein-containing complex assembly • response to external biotic stimulus • cellular component organization or biogenesis • regulation of signaling • positive regulation of innate immune response • defense response • negative regulation of response to stimulus • protein-containing complex organization • defense response to symbiont • regulation of cellular component biogenesis • negative regulation of signal transduction • negative regulation of immune system process • immune system process • regulation of cell communication • negative regulation of inflammasome-mediated signaling pathway • negative regulation of inflammatory response • regulation of inflammatory response • negative regulation of response to external stimulus • negative regulation of defense response • regulation of neuroinflammatory response • negative regulation of neuroinflammatory response • neuroinflammatory response • cell-cell signaling • neuron apoptotic process • negative regulation of neuron apoptotic process • regulation of neuron apoptotic process • negative regulation of execution phase of apoptosis • regulation of execution phase of apoptosis • execution phase of apoptosis • response to oxidative stress • regulation of response to oxidative stress • negative regulation of response to oxidative stress • interleukin-1 production • negative regulation of interleukin-1 production • regulation of interleukin-1 production • supramolecular fiber organization • cell chemotaxis • chemotaxis • leukocyte migration • cellular response to chemical stimulus • taxis • response to chemical • cell migration • cell motility • leukocyte chemotaxis • locomotion • organelle organization • mitochondrion organization • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • response to amyloid-beta • negative regulation of amyloid fibril formation • regulation of amyloid fibril formation • amyloid fibril formation • regulation of primary metabolic process • negative regulation of supramolecular fiber organization • protein metabolic process • negative regulation of protein metabolic process • regulation of protein metabolic process • primary metabolic process • regulation of supramolecular fiber organization • membrane-bounded organelle • intracellular organelle • cellular anatomical structure • intracellular anatomical structure • mitochondrion • organelle • cytoplasm • intracellular membrane-bounded organelle • cell projection • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular organelle • cellular anatomical structure • intracellular anatomical structure • mitochondrion • organelle • cytoplasm • intracellular membrane-bounded organelle • cell projection • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • sperm midpiece • extracellular region • perinuclear region of cytoplasm • extracellular space • nucleus • binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • signaling receptor activity • amide binding • amyloid-beta binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • RAGE receptor binding • protein binding • signaling receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • negative regulation of biological process • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • response to chemical • locomotion • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of transport • regulation of phagocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • multicellular organismal process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • anatomical structure development • system development • developmental process • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell migration • cell motility • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • cellular response to chemical stimulus • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell adhesion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • defense response to other organism • positive regulation of defense response • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • periplasmic space • tertiary granule membrane • membrane • intracellular vesicle • endomembrane system • tertiary granule • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • organelle membrane • secretory granule membrane • specific granule membrane • specific granule • cell periphery • plasma membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein-coupled receptor binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cell population proliferation • positive regulation of cell population proliferation • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • regulation of neural precursor cell proliferation • regulation of calcium ion transport • regulation of monoatomic ion transport • metal ion transport • calcium ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • negative regulation of signaling • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of secretion • exocytosis • regulation of exocytosis • negative regulation of apoptotic signaling pathway • apoptotic signaling pathway • regulation of apoptotic signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • dense core granule • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • dendrite • dendritic tree • neuron projection • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FME
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FME
Name	N-Formylmethionine
Synonyms	Formyl-methionine N-Formylmethionine N-formyl-L-methionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid L-N-Formylmethionine
Identifier
Formula	C6 H11 N O3 S
Molecular Weight	177.221
SMILES
PubChem	439750
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>7WVX_nogp_Chain_R S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F L L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WVX_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.