psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q14	R:R:R190	15.19	No	Yes	0	0	5
2	L:L:K15	R:R:I169	4.36	No	Yes	0	0	1
3	L:L:F16	L:L:W19	16.04	No	Yes	0	0	0
4	L:L:F16	R:R:L198	10.96	No	No	0	0	4
5	L:L:S18	R:R:F178	5.28	No	Yes	0	0	4
6	L:L:W19	R:R:R205	4	Yes	Yes	0	0	5
7	L:L:W19	R:R:V284	12.26	Yes	No	0	0	5
8	L:L:F20	R:R:L81	7.31	No	No	0	0	6
9	L:L:F20	R:R:H102	4.53	No	No	0	0	6
10	L:L:F20	R:R:F292	7.5	No	Yes	0	0	7
11	L:L:?21	R:R:D106	16.66	Yes	Yes	1	0	5
12	L:L:?21	R:R:L109	6.07	Yes	Yes	1	0	8
13	L:L:?21	R:R:F110	14.95	Yes	Yes	0	0	7
14	L:L:?21	R:R:R201	14.91	Yes	Yes	1	0	5
15	L:L:?21	R:R:R205	14.91	Yes	Yes	1	0	5
16	L:L:?21	R:R:W254	5.99	Yes	Yes	1	0	9
17	R:R:I282	R:R:L25	4.28	Yes	No	0	2	3
18	R:R:L25	R:R:P286	6.57	No	No	0	3	6
19	R:R:P286	R:R:P29	3.9	No	No	0	6	5
20	R:R:P29	R:R:S289	3.56	No	No	0	5	5
21	R:R:A86	R:R:L30	4.73	No	No	0	4	5
22	R:R:S289	R:R:V32	8.08	No	No	0	5	5
23	R:R:F293	R:R:V32	3.93	Yes	No	0	5	5
24	R:R:L33	R:R:L78	5.54	Yes	No	0	7	8
25	R:R:L33	R:R:S289	3	Yes	No	0	7	5
26	R:R:F292	R:R:L33	4.87	Yes	Yes	0	7	7
27	R:R:F293	R:R:V35	3.93	Yes	No	0	5	5
28	R:R:F293	R:R:T36	3.89	Yes	No	7	5	7
29	R:R:C296	R:R:T36	6.76	No	No	7	8	7
30	R:R:F37	R:R:P79	13	No	No	0	6	8
31	R:R:G40	R:R:T75	5.46	No	No	0	8	7
32	R:R:F72	R:R:V41	5.24	No	Yes	0	7	6
33	R:R:T75	R:R:V41	3.17	No	Yes	0	7	6
34	R:R:G43	R:R:P299	4.06	No	No	0	8	9
35	R:R:D71	R:R:N44	8.08	Yes	No	0	9	9
36	R:R:N44	R:R:P299	11.4	No	No	0	9	9
37	R:R:L313	R:R:L46	4.15	No	No	0	6	6
38	R:R:A68	R:R:V47	3.39	No	No	0	8	9
39	R:R:P299	R:R:V47	3.53	No	No	0	9	9
40	R:R:V303	R:R:V47	11.22	No	No	0	7	9
41	R:R:I48	R:R:L65	4.28	Yes	No	0	7	5
42	R:R:A68	R:R:I48	3.25	No	Yes	0	8	7
43	R:R:I48	R:R:L69	5.71	Yes	No	0	7	6
44	R:R:F72	R:R:I48	3.77	No	Yes	0	7	7
45	R:R:V50	R:R:W49	8.58	Yes	No	4	7	4
46	R:R:S316	R:R:W49	3.71	No	No	4	5	4
47	R:R:R54	R:R:V50	5.23	No	Yes	4	4	7
48	R:R:F309	R:R:V50	5.24	Yes	Yes	0	8	7
49	R:R:L313	R:R:V50	2.98	No	Yes	0	6	7
50	R:R:S316	R:R:V50	3.23	No	Yes	4	5	7
51	R:R:F53	R:R:G52	3.01	No	No	0	4	4
52	R:R:G52	R:R:L65	3.42	No	No	0	4	5
53	R:R:R54	R:R:S316	13.18	No	No	4	4	5
54	R:R:F309	R:R:M55	3.73	Yes	No	0	8	5
55	R:R:M55	R:R:R312	6.2	No	No	0	5	5
56	R:R:T58	R:R:T61	7.85	No	No	0	7	7
57	R:R:D122	R:R:V59	4.38	No	Yes	5	8	6
58	R:R:R137	R:R:V59	17	Yes	Yes	5	7	6
59	R:R:A142	R:R:V59	5.09	No	Yes	0	7	6
60	R:R:T60	R:R:Y64	6.24	No	Yes	0	7	8
61	R:R:R137	R:R:T60	3.88	Yes	No	0	7	7
62	R:R:C63	R:R:I119	3.27	No	Yes	0	7	9
63	R:R:I119	R:R:Y64	3.63	Yes	Yes	2	9	8
64	R:R:R123	R:R:Y64	7.2	Yes	Yes	2	9	8
65	R:R:Y302	R:R:Y64	2.98	Yes	Yes	2	9	8
66	R:R:V303	R:R:Y64	7.57	No	Yes	0	7	8
67	R:R:I146	R:R:N66	8.5	No	No	0	7	9
68	R:R:N66	R:R:W150	5.65	No	Yes	0	9	9
69	R:R:L67	R:R:N298	5.49	No	Yes	0	9	9
70	R:R:D71	R:R:S112	7.36	Yes	No	0	9	9
71	R:R:D71	R:R:S295	10.31	Yes	No	0	9	9
72	R:R:D71	R:R:N298	8.08	Yes	Yes	0	9	9
73	R:R:N108	R:R:S73	8.94	No	No	0	8	7
74	R:R:F74	R:R:L78	7.31	Yes	No	0	7	8
75	R:R:F74	R:R:V105	5.24	Yes	Yes	1	7	6
76	R:R:F74	R:R:L109	9.74	Yes	Yes	1	7	8
77	R:R:F292	R:R:F74	12.86	Yes	Yes	1	7	7
78	R:R:F74	R:R:S295	7.93	Yes	No	0	7	9
79	R:R:I101	R:R:T77	4.56	No	No	0	5	7
80	R:R:T77	R:R:V104	3.17	No	No	0	7	5
81	R:R:T77	R:R:V105	3.17	No	Yes	0	7	6
82	R:R:F80	R:R:F93	10.72	No	Yes	0	6	7
83	R:R:F80	R:R:I101	10.05	No	No	0	6	5
84	R:R:L81	R:R:V105	2.98	No	Yes	0	6	6
85	R:R:S84	R:R:W91	6.18	No	Yes	0	5	9
86	R:R:M85	R:R:N285	15.43	No	No	0	6	4
87	R:R:M87	R:R:P92	10.06	No	No	0	4	3
88	R:R:E89	R:R:N285	6.57	No	No	0	4	4
89	R:R:D173	R:R:K90	11.06	Yes	No	3	3	4
90	R:R:K90	R:R:Y175	3.58	No	No	3	4	3
91	R:R:F93	R:R:W91	12.03	Yes	Yes	0	7	9
92	R:R:C98	R:R:W91	6.53	No	Yes	6	9	9
93	R:R:I101	R:R:W91	3.52	No	Yes	0	5	9
94	R:R:C176	R:R:W91	9.14	No	Yes	6	9	9
95	R:R:F93	R:R:P92	8.67	Yes	No	0	7	3
96	R:R:F93	R:R:L97	4.87	Yes	No	0	7	7
97	R:R:K99	R:R:W95	4.64	No	No	0	7	4
98	R:R:F96	R:R:L100	4.87	No	No	0	1	5
99	R:R:C98	R:R:T166	3.38	No	Yes	6	9	5
100	R:R:C176	R:R:C98	5.46	No	No	6	9	9
101	R:R:L100	R:R:V104	2.98	No	No	0	5	5
102	R:R:H102	R:R:L164	5.14	No	No	0	6	5
103	R:R:F161	R:R:I103	16.33	No	No	0	4	5
104	R:R:L109	R:R:V105	2.98	Yes	Yes	1	8	6
105	R:R:D106	R:R:V160	4.38	Yes	No	1	5	4
106	R:R:D106	R:R:R201	5.96	Yes	Yes	1	5	5
107	R:R:I107	R:R:L154	5.71	Yes	No	0	5	4
108	R:R:I107	R:R:T157	6.08	Yes	No	0	5	7
109	R:R:F292	R:R:L109	7.31	Yes	Yes	1	7	8
110	R:R:F110	R:R:F114	7.5	Yes	No	0	7	6
111	R:R:F110	R:R:L156	7.31	Yes	Yes	0	7	5
112	R:R:F110	R:R:G209	3.01	Yes	No	0	7	6
113	R:R:P213	R:R:V113	5.3	No	No	0	9	7
114	R:R:F250	R:R:V113	3.93	Yes	No	1	9	7
115	R:R:V113	R:R:W254	4.9	No	Yes	1	7	9
116	R:R:F114	R:R:L152	7.31	No	No	0	6	4
117	R:R:L115	R:R:P149	6.57	No	No	0	8	7
118	R:R:L115	R:R:W150	3.42	No	Yes	0	8	9
119	R:R:F250	R:R:I116	3.77	Yes	No	0	9	8
120	R:R:I116	R:R:N298	8.5	No	Yes	0	8	9
121	R:R:I116	R:R:Y302	8.46	No	Yes	0	8	9
122	R:R:F118	R:R:V145	5.24	No	No	0	7	5
123	R:R:F118	R:R:I146	5.02	No	No	0	7	7
124	R:R:I119	R:R:R123	6.26	Yes	Yes	2	9	9
125	R:R:I119	R:R:Y302	7.25	Yes	Yes	2	9	9
126	R:R:A120	R:R:Y221	5.34	No	Yes	0	9	8
127	R:R:I216	R:R:L121	4.28	No	No	0	6	7
128	R:R:C220	R:R:L121	3.17	No	No	0	7	7
129	R:R:C126	R:R:D122	4.67	No	No	5	8	8
130	R:R:D122	R:R:R137	13.1	No	Yes	5	8	7
131	R:R:R123	R:R:Y221	8.23	Yes	Yes	2	9	8
132	R:R:R123	R:R:Y302	8.23	Yes	Yes	2	9	9
133	R:R:C124	R:R:L128	4.76	No	Yes	0	8	7
134	R:R:C124	R:R:C220	5.46	No	No	0	8	7
135	R:R:I125	R:R:W132	3.52	No	Yes	0	5	5
136	R:R:C126	R:R:R137	6.96	No	Yes	5	8	7
137	R:R:L128	R:R:V127	2.98	Yes	No	9	7	8
138	R:R:I224	R:R:V127	4.61	No	No	0	8	8
139	R:R:K227	R:R:V127	3.04	No	No	9	5	8
140	R:R:K227	R:R:L128	5.64	No	Yes	9	5	7
141	R:R:H129	R:R:P130	3.05	No	No	0	6	8
142	R:R:H129	R:R:W132	6.35	No	Yes	0	6	5
143	R:R:H136	R:R:W132	17.98	No	Yes	0	3	5
144	R:R:H136	R:R:N135	5.1	No	No	0	3	4
145	R:R:S140	R:R:T138	4.8	No	No	0	4	6
146	R:R:G148	R:R:P149	4.06	No	No	0	3	7
147	R:R:M197	R:R:P159	3.35	No	No	0	1	8
148	R:R:L164	R:R:V160	4.47	No	No	0	5	4
149	R:R:R201	R:R:V160	3.92	Yes	No	1	5	4
150	R:R:F163	R:R:L162	9.74	Yes	No	0	5	5
151	R:R:F163	R:R:F178	3.22	Yes	Yes	1	5	4
152	R:R:F163	R:R:F180	11.79	Yes	Yes	1	5	6
153	R:R:F163	R:R:W183	16.04	Yes	No	0	5	4
154	R:R:F178	R:R:L164	10.96	Yes	No	0	4	5
155	R:R:T166	R:R:T174	3.14	Yes	No	0	5	5
156	R:R:C176	R:R:T166	3.38	No	Yes	6	9	5
157	R:R:T177	R:R:V167	4.76	No	No	0	3	1
158	R:R:N179	R:R:V167	5.91	No	No	0	3	1
159	R:R:T168	R:R:T174	3.14	No	No	0	2	5
160	R:R:I169	R:R:P170	5.08	Yes	No	0	1	3
161	R:R:D173	R:R:I169	4.2	Yes	Yes	3	3	1
162	R:R:I169	R:R:Y175	6.04	Yes	No	3	1	3
163	R:R:D173	R:R:N171	12.12	Yes	No	0	3	4
164	R:R:D173	R:R:Y175	12.64	Yes	No	3	3	3
165	R:R:F178	R:R:F180	5.36	Yes	Yes	1	4	6
166	R:R:F178	R:R:R201	4.28	Yes	Yes	1	4	5
167	R:R:A194	R:R:F180	4.16	No	Yes	0	3	6
168	R:R:F180	R:R:M197	6.22	Yes	No	0	6	1
169	R:R:A181	R:R:R190	5.53	No	Yes	0	5	5
170	R:R:P187	R:R:T186	3.5	No	No	0	5	6
171	R:R:E189	R:R:T186	14.11	No	No	0	3	6
172	R:R:L191	R:R:R190	3.64	No	Yes	0	1	5
173	R:R:F273	R:R:L191	3.65	No	No	0	5	1
174	R:R:L198	R:R:L268	5.54	No	No	0	4	3
175	R:R:T199	R:R:T265	3.14	No	No	0	3	4
176	R:R:G202	R:R:R205	6	No	Yes	0	4	5
177	R:R:G202	R:R:T265	5.46	No	No	0	4	4
178	R:R:F257	R:R:R205	3.21	Yes	Yes	1	7	5
179	R:R:Q258	R:R:R205	8.18	Yes	Yes	1	8	5
180	R:R:A261	R:R:R205	5.53	No	Yes	0	5	5
181	R:R:F206	R:R:F210	5.36	Yes	No	1	6	9
182	R:R:F206	R:R:Q258	3.51	Yes	Yes	1	6	8
183	R:R:F206	R:R:L262	13.4	Yes	No	0	6	5
184	R:R:F210	R:R:F255	6.43	No	No	0	9	6
185	R:R:F210	R:R:Q258	14.05	No	Yes	1	9	8
186	R:R:L212	R:R:P213	4.93	No	No	0	5	9
187	R:R:F250	R:R:M214	6.22	Yes	No	0	9	6
188	R:R:F251	R:R:M214	4.98	No	No	0	6	6
189	R:R:V217	R:R:Y221	3.79	No	Yes	0	8	8
190	R:R:V217	R:R:V247	3.21	No	No	0	8	8
191	R:R:F250	R:R:V217	6.55	Yes	No	0	9	8
192	R:R:L243	R:R:Y221	3.52	No	Yes	0	8	8
193	R:R:V246	R:R:Y221	5.05	No	Yes	2	8	8
194	R:R:Y221	R:R:Y302	4.96	Yes	Yes	2	8	9
195	R:R:K227	R:R:K231	7.18	No	No	0	5	5
196	R:R:I228	R:R:M233	4.37	No	No	0	8	3
197	R:R:I228	R:R:I234	5.89	No	No	0	8	4
198	R:R:K231	R:R:M233	7.2	No	No	0	5	3
199	R:R:I234	R:R:P239	3.39	No	No	0	4	7
200	R:R:R241	R:R:S237	5.27	No	No	0	5	4
201	R:R:R238	R:R:R310	3.2	Yes	No	0	7	8
202	R:R:V242	R:R:V305	8.02	No	No	10	8	7
203	R:R:V246	R:R:Y302	6.31	No	Yes	2	8	9
204	R:R:N294	R:R:S249	2.98	Yes	No	0	9	7
205	R:R:L297	R:R:S249	4.5	No	No	0	6	7
206	R:R:L301	R:R:S249	3	No	No	0	8	7
207	R:R:F250	R:R:W254	6.01	Yes	Yes	1	9	9
208	R:R:F251	R:R:F255	15	No	No	0	6	6
209	R:R:C253	R:R:N294	7.87	No	Yes	0	8	9
210	R:R:F257	R:R:W254	3.01	Yes	Yes	1	7	9
211	R:R:Q258	R:R:W254	3.29	Yes	Yes	1	8	9
212	R:R:A291	R:R:W254	5.19	No	Yes	1	8	9
213	R:R:N294	R:R:W254	6.78	Yes	Yes	0	9	9
214	R:R:F255	R:R:L259	3.65	No	No	0	6	5
215	R:R:P256	R:R:T287	3.5	No	No	0	9	7
216	R:R:F257	R:R:Q258	8.2	Yes	Yes	1	7	8
217	R:R:F257	R:R:T287	3.89	Yes	No	0	7	7
218	R:R:A291	R:R:F257	4.16	No	Yes	1	8	7
219	R:R:T287	R:R:V260	3.17	No	No	0	7	5
220	R:R:L263	R:R:W267	9.11	No	Yes	0	5	3
221	R:R:V266	R:R:W267	6.13	No	Yes	0	4	3
222	R:R:E270	R:R:W267	13.08	No	Yes	11	2	3
223	R:R:W267	R:R:Y277	27.97	Yes	No	11	3	3
224	R:R:I280	R:R:W267	4.7	No	Yes	0	4	3
225	R:R:L268	R:R:L272	5.54	No	No	0	3	3
226	R:R:F273	R:R:K269	3.72	No	No	0	5	4
227	R:R:E270	R:R:Y277	8.98	No	No	11	2	3
228	R:R:I280	R:R:M271	5.83	No	No	0	4	1
229	R:R:F273	R:R:Y274	11.35	No	No	0	5	5
230	R:R:N285	R:R:V284	2.96	No	No	0	4	5
231	R:R:F292	R:R:S288	3.96	Yes	No	0	7	6
232	R:R:C296	R:R:F293	8.38	No	Yes	7	8	5
233	R:R:F293	R:R:L297	6.09	Yes	No	0	5	6
234	R:R:N294	R:R:N298	9.54	Yes	Yes	0	9	9
235	R:R:F304	R:R:M300	3.73	No	No	0	7	7
236	R:R:F309	R:R:V303	7.87	Yes	No	0	8	7
237	R:R:F304	R:R:F309	5.36	No	Yes	0	7	8
238	R:R:Q307	R:R:R310	7.01	No	No	0	5	8
239	R:R:E311	R:R:H315	7.39	No	No	0	4	4
240	R:R:H315	R:R:I314	6.63	No	No	0	4	3
241	R:R:I103	R:R:I107	2.94	No	Yes	0	5	5
242	R:R:I204	R:R:I208	2.94	No	No	8	4	5
243	R:R:I62	R:R:M143	2.92	No	No	0	7	4
244	R:R:N179	R:R:T165	2.92	No	No	0	3	4
245	R:R:I195	R:R:K269	2.91	No	No	0	1	4
246	R:R:D106	R:R:T157	2.89	Yes	No	0	5	7
247	R:R:F114	R:R:P149	2.89	No	No	0	6	7
248	R:R:K90	R:R:M87	2.88	No	No	0	4	4
249	R:R:I82	R:R:L33	2.85	No	Yes	0	7	7
250	R:R:I204	R:R:L156	2.85	No	Yes	8	4	5
251	R:R:I208	R:R:L156	2.85	No	Yes	8	5	5
252	R:R:I195	R:R:L268	2.85	No	No	0	1	3
253	R:R:I216	R:R:L212	2.85	No	No	0	6	5
254	R:R:I282	R:R:L283	2.85	Yes	No	0	2	6
255	R:R:L30	R:R:M85	2.83	No	No	0	5	6
256	R:R:I107	R:R:N108	2.83	Yes	No	0	5	8
257	L:L:T17	R:R:E89	2.82	No	No	0	0	4
258	L:L:W19	R:R:G264	2.81	Yes	No	0	0	4
259	R:R:G111	R:R:W150	2.81	No	Yes	0	7	9
260	R:R:A51	R:R:F309	2.77	No	Yes	0	7	8
261	R:R:L128	R:R:L223	2.77	Yes	No	0	7	3
262	R:R:A133	R:R:R137	2.77	No	Yes	0	5	7
263	R:R:N135	R:R:Q134	2.64	No	No	0	4	5
264	R:R:F37	R:R:V41	2.62	No	Yes	0	6	6
265	R:R:F93	R:R:V83	2.62	Yes	No	0	7	5
266	R:R:F180	R:R:V193	2.62	Yes	No	0	6	4
267	R:R:R26	R:R:T23	2.59	No	No	0	4	2
268	R:R:A70	R:R:W150	2.59	No	Yes	0	8	9
269	R:R:E188	R:R:E189	2.54	No	No	0	3	3
270	R:R:S182	R:R:W183	2.47	No	No	0	7	4
271	R:R:T165	R:R:W95	2.43	No	No	0	4	4
272	R:R:T166	R:R:W95	2.43	Yes	No	0	5	4
273	R:R:I282	R:R:Y22	2.42	Yes	No	0	2	2
274	R:R:I279	R:R:Y277	2.42	No	No	0	3	3
275	L:L:W19	R:R:I280	2.35	Yes	No	0	0	4
276	R:R:G184	R:R:G185	2.11	No	No	0	3	3
277	R:R:A20	R:R:G21	1.95	No	No	0	4	4
278	R:R:A120	R:R:G117	1.95	No	No	0	9	7
279	R:R:G172	R:R:T168	1.82	No	No	0	4	2
280	R:R:P130	R:R:V131	1.77	No	No	0	8	5
281	R:R:G34	R:R:I82	1.76	No	No	0	5	7
282	R:R:G275	R:R:K276	1.74	No	No	0	1	1
283	R:R:A218	R:R:V247	1.7	No	No	0	5	8
284	R:R:L28	R:R:P29	1.64	No	No	0	5	5
285	R:R:E89	R:R:G88	1.64	No	No	0	4	3
286	R:R:L158	R:R:P159	1.64	No	No	0	4	8
287	R:R:L290	R:R:P256	1.64	No	No	0	8	9
288	R:R:S211	R:R:S215	1.63	No	No	0	4	3
289	R:R:A153	R:R:I107	1.62	No	Yes	0	8	5
290	R:R:V31	R:R:V32	1.6	No	No	0	6	5
291	R:R:V139	R:R:V59	1.6	Yes	Yes	0	3	6
292	R:R:T23	R:R:V24	1.59	No	No	0	2	4
293	R:R:C296	R:R:L39	1.59	No	No	0	8	5
294	R:R:T138	R:R:V139	1.59	No	Yes	0	6	3
295	R:R:T244	R:R:V247	1.59	No	No	0	4	8
296	R:R:A225	R:R:L240	1.58	No	No	0	5	5
297	R:R:A225	R:R:L243	1.58	No	No	0	5	8
298	R:R:A245	R:R:L301	1.58	No	No	0	6	8
299	R:R:T56	R:R:T58	1.57	No	No	0	6	7
300	R:R:I62	R:R:V139	1.54	No	Yes	0	7	3
301	R:R:I146	R:R:V147	1.54	No	No	0	7	4
302	R:R:I151	R:R:V155	1.54	No	No	0	3	4
303	R:R:I203	R:R:V207	1.54	No	No	0	4	4
304	R:R:I208	R:R:V207	1.54	No	No	0	5	4
305	R:R:M55	R:R:T61	1.51	No	No	0	5	7
306	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
307	R:R:G184	R:R:R190	1.5	No	Yes	0	3	5
308	R:R:G306	R:R:R238	1.5	No	Yes	0	8	7
309	R:R:L39	R:R:V38	1.49	No	No	0	5	5
310	R:R:L42	R:R:V41	1.49	No	Yes	0	4	6
311	R:R:L141	R:R:V145	1.49	No	No	0	3	5
312	R:R:L156	R:R:V155	1.49	Yes	No	0	5	4
313	R:R:D281	R:R:V284	1.46	No	No	0	4	5
314	R:R:I282	R:R:K278	1.45	Yes	No	0	2	1
315	R:R:P239	R:R:R238	1.44	No	Yes	0	7	7
316	R:R:I219	R:R:L223	1.43	No	No	0	3	3
317	R:R:H229	R:R:I234	1.33	No	No	0	3	4
318	R:R:F206	R:R:S211	1.32	Yes	No	0	6	4
319	R:R:R238	R:R:S236	1.32	Yes	No	0	7	6
320	R:R:R57	R:R:V139	1.31	No	Yes	0	6	3
321	R:R:R238	R:R:V242	1.31	Yes	No	10	7	8
322	R:R:R238	R:R:V305	1.31	Yes	No	10	7	7
323	R:R:R241	R:R:V242	1.31	No	No	0	5	8
324	R:R:D308	R:R:E311	1.3	No	No	0	6	4
325	R:R:S19	R:R:Y22	1.27	No	No	0	4	2
326	R:R:F251	R:R:I252	1.26	No	No	0	6	6
327	R:R:E311	R:R:R312	1.16	No	No	0	4	5
328	R:R:R137	R:R:W132	1	Yes	Yes	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W19	7.492	5	0	0
2	L:L:?21	12.2483	6	1	0
3	R:R:L33	4.065	4	0	7
4	R:R:V41	3.13	4	0	6
5	R:R:I48	4.2525	4	0	7
6	R:R:V50	5.052	5	4	7
7	R:R:V59	7.0175	4	5	6
8	R:R:Y64	5.524	5	2	8
9	R:R:D71	8.4575	4	0	9
10	R:R:F74	8.616	5	1	7
11	R:R:W91	7.48	5	6	9
12	R:R:F93	6.73667	6	0	7
13	R:R:V105	3.5925	4	1	6
14	R:R:D106	7.4725	4	1	5
15	R:R:I107	3.836	5	0	5
16	R:R:L109	6.525	4	1	8
17	R:R:F110	8.1925	4	0	7
18	R:R:I119	5.1025	4	2	9
19	R:R:R123	7.48	4	2	9
20	R:R:L128	4.0375	4	9	7
21	R:R:W132	7.2125	4	0	5
22	R:R:R137	7.45167	6	5	7
23	R:R:V139	1.51	4	0	3
24	R:R:W150	3.6175	4	0	9
25	R:R:L156	3.625	4	8	5
26	R:R:F163	10.1975	4	1	5
27	R:R:T166	3.0825	4	6	5
28	R:R:I169	4.92	4	3	1
29	R:R:D173	10.005	4	3	3
30	R:R:F178	5.82	5	1	4
31	R:R:F180	6.03	5	1	6
32	R:R:R190	6.465	4	0	5
33	R:R:R201	7.2675	4	1	5
34	R:R:R205	6.97167	6	1	5
35	R:R:F206	5.8975	4	1	6
36	R:R:Y221	5.14833	6	2	8
37	R:R:R238	1.68	6	10	7
38	R:R:F250	5.296	5	1	9
39	R:R:W254	5.02429	7	1	9
40	R:R:F257	4.494	5	1	7
41	R:R:Q258	7.446	5	1	8
42	R:R:W267	12.198	5	11	3
43	R:R:I282	2.75	4	0	2
44	R:R:F292	7.3	5	1	7
45	R:R:F293	5.244	5	7	5
46	R:R:N294	6.7925	4	0	9
47	R:R:N298	7.9025	4	0	9
48	R:R:Y302	6.365	6	2	9
49	R:R:F309	4.994	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D173	R:R:I169	10.0961	4.2	Yes	Yes	3	3	1
2	R:R:D173	R:R:K90	16.9813	11.06	Yes	No	3	3	4
3	R:R:K90	R:R:M87	33.9192	2.88	No	No	0	4	4
4	R:R:M87	R:R:P92	37.3183	10.06	No	No	0	4	3
5	R:R:F93	R:R:P92	40.7078	8.67	Yes	No	0	7	3
6	R:R:F80	R:R:F93	26.1504	10.72	No	Yes	0	6	7
7	R:R:F80	R:R:I101	27.7341	10.05	No	No	0	6	5
8	R:R:I101	R:R:T77	94.5922	4.56	No	No	0	5	7
9	R:R:T77	R:R:V105	99.9807	3.17	No	Yes	0	7	6
10	R:R:L109	R:R:V105	65.8394	2.98	Yes	Yes	1	8	6
11	L:L:?21	R:R:L109	85.6646	6.07	Yes	Yes	1	0	8
12	L:L:?21	R:R:R205	62.5078	14.91	Yes	Yes	1	0	5
13	L:L:W19	R:R:R205	92.9313	4	Yes	Yes	0	0	5
14	L:L:F16	L:L:W19	40.7223	16.04	No	Yes	0	0	0
15	L:L:F16	R:R:L198	38.0957	10.96	No	No	0	0	4
16	R:R:L198	R:R:L268	35.4208	5.54	No	No	0	4	3
17	R:R:I195	R:R:L268	29.8344	2.85	No	No	0	1	3
18	R:R:I195	R:R:K269	26.8939	2.91	No	No	0	1	4
19	R:R:F273	R:R:K269	23.9438	3.72	No	No	0	5	4
20	R:R:F273	R:R:L191	18.0146	3.65	No	No	0	5	1
21	R:R:L191	R:R:R190	15.0355	3.64	No	Yes	0	1	5
22	R:R:I169	R:R:Y175	10.0816	6.04	Yes	No	3	1	3
23	R:R:K90	R:R:Y175	13.5242	3.58	No	No	3	4	3
24	R:R:F93	R:R:W91	28.0865	12.03	Yes	Yes	0	7	9
25	R:R:I101	R:R:W91	65.7042	3.52	No	Yes	0	5	9
26	L:L:?21	R:R:R201	25.1654	14.91	Yes	Yes	1	0	5
27	R:R:F178	R:R:R201	21.0661	4.28	Yes	Yes	1	4	5
28	L:L:W19	R:R:V284	26.131	12.26	Yes	No	0	0	5
29	R:R:F292	R:R:L109	23.0071	7.31	Yes	Yes	1	7	8
30	L:L:?21	R:R:D106	17.7056	16.66	Yes	Yes	1	0	5
31	L:L:?21	R:R:F110	37.975	14.95	Yes	Yes	0	0	7
32	L:L:?21	R:R:W254	100	5.99	Yes	Yes	1	0	9
33	R:R:F257	R:R:R205	29.2695	3.21	Yes	Yes	1	7	5
34	R:R:F257	R:R:W254	31.6209	3.01	Yes	Yes	1	7	9
35	R:R:Q258	R:R:R205	32.0796	8.18	Yes	Yes	1	8	5
36	R:R:Q258	R:R:W254	34.8559	3.29	Yes	Yes	1	8	9
37	R:R:F292	R:R:L33	31.5147	4.87	Yes	Yes	0	7	7
38	R:R:L33	R:R:S289	35.1745	3	Yes	No	0	7	5
39	R:R:P29	R:R:S289	25.1895	3.56	No	No	0	5	5
40	R:R:P286	R:R:P29	19.5983	3.9	No	No	0	6	5
41	R:R:L25	R:R:P286	16.7834	6.57	No	No	0	3	6
42	R:R:I282	R:R:L25	14.2292	4.28	Yes	No	0	2	3
43	R:R:N285	R:R:V284	20.2211	2.96	No	No	0	4	5
44	R:R:S289	R:R:V32	11.4191	8.08	No	No	0	5	5
45	R:R:N294	R:R:W254	34.2523	6.78	Yes	Yes	0	9	9
46	R:R:N294	R:R:S249	18.4346	2.98	Yes	No	0	9	7
47	R:R:L297	R:R:S249	13.529	4.5	No	No	0	6	7
48	R:R:F293	R:R:L297	11.8826	6.09	Yes	No	0	5	6
49	R:R:F74	R:R:L109	10.3423	9.74	Yes	Yes	1	7	8
50	R:R:F74	R:R:L78	12.573	7.31	Yes	No	0	7	8
51	R:R:F74	R:R:S295	41.7556	7.93	Yes	No	0	7	9
52	R:R:D71	R:R:S295	41.3307	10.31	Yes	No	0	9	9
53	R:R:D71	R:R:N44	42.0598	8.08	Yes	No	0	9	9
54	R:R:N44	R:R:P299	40.1236	11.4	No	No	0	9	9
55	R:R:P299	R:R:V47	36.541	3.53	No	No	0	9	9
56	R:R:A68	R:R:V47	41.6107	3.39	No	No	0	8	9
57	R:R:A68	R:R:I48	38.4675	3.25	No	Yes	0	8	7
58	R:R:F72	R:R:I48	22.6063	3.77	No	Yes	0	7	7
59	R:R:F72	R:R:V41	19.4051	5.24	No	Yes	0	7	6
60	R:R:N294	R:R:N298	25.6144	9.54	Yes	Yes	0	9	9
61	R:R:D71	R:R:N298	34.0882	8.08	Yes	Yes	0	9	9
62	R:R:F250	R:R:W254	83.6415	6.01	Yes	Yes	1	9	9
63	R:R:F250	R:R:I116	75.5589	3.77	Yes	No	0	9	8
64	R:R:I116	R:R:Y302	91.2993	8.46	No	Yes	0	8	9
65	R:R:Y302	R:R:Y64	84.1678	2.98	Yes	Yes	2	9	8
66	R:R:V303	R:R:Y64	44.6912	7.57	No	Yes	0	7	8
67	R:R:V303	R:R:V47	29.2405	11.22	No	No	0	7	9
68	R:R:F309	R:R:V303	36.232	7.87	Yes	No	0	8	7
69	R:R:F309	R:R:V50	11.815	5.24	Yes	Yes	0	8	7
70	R:R:F309	R:R:M55	17.5945	3.73	Yes	No	0	8	5
71	R:R:T60	R:R:Y64	48.9788	6.24	No	Yes	0	7	8
72	R:R:R137	R:R:T60	46.724	3.88	Yes	No	0	7	7
73	R:R:R137	R:R:V59	19.2265	17	Yes	Yes	5	7	6
74	R:R:F250	R:R:V217	17.5897	6.55	Yes	No	0	9	8
75	R:R:V217	R:R:Y221	13.8139	3.79	No	Yes	0	8	8
76	R:R:F110	R:R:F114	23.7217	7.5	Yes	No	0	7	6
77	R:R:F114	R:R:P149	20.4481	2.89	No	No	0	6	7
78	R:R:L115	R:R:P149	17.1358	6.57	No	No	0	8	7
79	R:R:L115	R:R:W150	15.4652	3.42	No	Yes	0	8	9
80	R:R:N66	R:R:W150	10.3954	5.65	No	Yes	0	9	9
81	R:R:D106	R:R:T157	13.5918	2.89	Yes	No	0	5	7
82	R:R:I107	R:R:T157	11.926	6.08	Yes	No	0	5	7
83	R:R:C98	R:R:W91	19.2217	6.53	No	Yes	6	9	9
84	R:R:C176	R:R:W91	19.2217	9.14	No	Yes	6	9	9
85	R:R:C98	R:R:T166	17.5221	3.38	No	Yes	6	9	5
86	R:R:T166	R:R:W95	21.1434	2.43	Yes	No	0	5	4
87	R:R:C176	R:R:T166	17.5221	3.38	No	Yes	6	9	5
88	R:R:F110	R:R:L156	12.095	7.31	Yes	Yes	0	7	5
89	R:R:V113	R:R:W254	38.284	4.9	No	Yes	1	7	9
90	R:R:P213	R:R:V113	48.4139	5.3	No	No	0	9	7
91	R:R:L212	R:R:P213	46.7095	4.93	No	No	0	5	9
92	R:R:I216	R:R:L212	44.9954	2.85	No	No	0	6	5
93	R:R:I216	R:R:L121	43.2717	4.28	No	No	0	6	7
94	R:R:C220	R:R:L121	41.7556	3.17	No	No	0	7	7
95	R:R:C124	R:R:C220	40.0126	5.46	No	No	0	8	7
96	R:R:C124	R:R:L128	38.2599	4.76	No	Yes	0	8	7
97	R:R:R137	R:R:W132	19.27	1	Yes	Yes	0	7	5
98	R:R:K227	R:R:L128	29.1777	5.64	No	Yes	9	5	7
99	R:R:V139	R:R:V59	14.5382	1.6	Yes	Yes	0	3	6
100	R:R:F178	R:R:F180	10.4486	5.36	Yes	Yes	1	4	6
101	R:R:T166	R:R:T174	10.6127	3.14	Yes	No	0	5	5
102	R:R:T165	R:R:W95	14.1326	2.43	No	No	0	4	4
103	R:R:N179	R:R:T165	10.6127	2.92	No	No	0	3	4
104	R:R:K227	R:R:K231	27.7099	7.18	No	No	0	5	5
105	R:R:K231	R:R:M233	25.8896	7.2	No	No	0	5	3
106	R:R:I228	R:R:M233	24.0597	4.37	No	No	0	8	3
107	R:R:I228	R:R:I234	22.2201	5.89	No	No	0	8	4
108	R:R:I234	R:R:P239	18.5119	3.39	No	No	0	4	7
109	R:R:P239	R:R:R238	16.6433	1.44	No	Yes	0	7	7
110	L:L:W19	R:R:I280	23.6686	2.35	Yes	No	0	0	4
111	R:R:I280	R:R:W267	18.0146	4.7	No	Yes	0	4	3
112	R:R:F74	R:R:V105	35.4836	5.24	Yes	Yes	1	7	6
113	R:R:F292	R:R:F74	13.1669	12.86	Yes	Yes	1	7	7
114	R:R:L33	R:R:L78	11.2066	5.54	Yes	No	0	7	8
115	R:R:I116	R:R:N298	20.4529	8.5	No	Yes	0	8	9
116	R:R:F250	R:R:V113	11.8198	3.93	Yes	No	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q14	R:R:R190	15.19	0	No	Yes	0	5	0	1
L:L:K15	R:R:I169	4.36	0	No	Yes	0	1	0	1
L:L:F16	R:R:L198	10.96	0	No	No	0	4	0	1
L:L:S18	R:R:F178	5.28	0	No	Yes	0	4	0	1
L:L:W19	R:R:R205	4	0	Yes	Yes	0	5	0	1
L:L:W19	R:R:V284	12.26	0	Yes	No	0	5	0	1
L:L:F20	R:R:L81	7.31	0	No	No	0	6	0	1
L:L:F20	R:R:H102	4.53	0	No	No	0	6	0	1
L:L:F20	R:R:F292	7.5	0	No	Yes	0	7	0	1
L:L:?21	R:R:D106	16.66	1	Yes	Yes	0	5	0	1
L:L:?21	R:R:L109	6.07	1	Yes	Yes	0	8	0	1
L:L:?21	R:R:F110	14.95	1	Yes	Yes	0	7	0	1
L:L:?21	R:R:R201	14.91	1	Yes	Yes	0	5	0	1
L:L:?21	R:R:R205	14.91	1	Yes	Yes	0	5	0	1
L:L:?21	R:R:W254	5.99	1	Yes	Yes	0	9	0	1
R:R:F292	R:R:L33	4.87	1	Yes	Yes	7	7	1	2
R:R:F74	R:R:V105	5.24	1	Yes	Yes	7	6	2	2
R:R:F74	R:R:L109	9.74	1	Yes	Yes	7	8	2	1
R:R:F292	R:R:F74	12.86	1	Yes	Yes	7	7	1	2
R:R:L81	R:R:V105	2.98	0	No	Yes	6	6	1	2
R:R:E89	R:R:N285	6.57	0	No	No	4	4	1	2
R:R:H102	R:R:L164	5.14	0	No	No	6	5	1	2
R:R:L109	R:R:V105	2.98	1	Yes	Yes	8	6	1	2
R:R:D106	R:R:V160	4.38	1	Yes	No	5	4	1	2
R:R:D106	R:R:R201	5.96	1	Yes	Yes	5	5	1	1
R:R:F292	R:R:L109	7.31	1	Yes	Yes	7	8	1	1
R:R:F110	R:R:F114	7.5	0	Yes	No	7	6	1	2
R:R:F110	R:R:L156	7.31	0	Yes	Yes	7	5	1	2
R:R:F110	R:R:G209	3.01	0	Yes	No	7	6	1	2
R:R:F250	R:R:V113	3.93	1	Yes	No	9	7	2	2
R:R:V113	R:R:W254	4.9	1	No	Yes	7	9	2	1
R:R:L164	R:R:V160	4.47	0	No	No	5	4	2	2
R:R:R201	R:R:V160	3.92	1	Yes	No	5	4	1	2
R:R:F163	R:R:F178	3.22	1	Yes	Yes	5	4	2	1
R:R:F163	R:R:F180	11.79	1	Yes	Yes	5	6	2	2
R:R:F178	R:R:L164	10.96	1	Yes	No	4	5	1	2
R:R:I169	R:R:P170	5.08	3	Yes	No	1	3	1	2
R:R:D173	R:R:I169	4.2	3	Yes	Yes	3	1	2	1
R:R:I169	R:R:Y175	6.04	3	Yes	No	1	3	1	2
R:R:D173	R:R:Y175	12.64	3	Yes	No	3	3	2	2
R:R:F178	R:R:F180	5.36	1	Yes	Yes	4	6	1	2
R:R:F178	R:R:R201	4.28	1	Yes	Yes	4	5	1	1
R:R:A181	R:R:R190	5.53	0	No	Yes	5	5	2	1
R:R:L191	R:R:R190	3.64	0	No	Yes	1	5	2	1
R:R:L198	R:R:L268	5.54	0	No	No	4	3	1	2
R:R:G202	R:R:R205	6	0	No	Yes	4	5	2	1
R:R:F257	R:R:R205	3.21	1	Yes	Yes	7	5	2	1
R:R:Q258	R:R:R205	8.18	1	Yes	Yes	8	5	2	1
R:R:A261	R:R:R205	5.53	0	No	Yes	5	5	2	1
R:R:F250	R:R:W254	6.01	1	Yes	Yes	9	9	2	1
R:R:F257	R:R:W254	3.01	1	Yes	Yes	7	9	2	1
R:R:Q258	R:R:W254	3.29	1	Yes	Yes	8	9	2	1
R:R:A291	R:R:W254	5.19	1	No	Yes	8	9	2	1
R:R:N294	R:R:W254	6.78	0	Yes	Yes	9	9	2	1
R:R:F257	R:R:Q258	8.2	1	Yes	Yes	7	8	2	2
R:R:A291	R:R:F257	4.16	1	No	Yes	8	7	2	2
R:R:I280	R:R:W267	4.7	0	No	Yes	4	3	1	2
R:R:I280	R:R:M271	5.83	0	No	No	4	1	1	2
R:R:N285	R:R:V284	2.96	0	No	No	4	5	2	1
R:R:F292	R:R:S288	3.96	1	Yes	No	7	6	1	2
R:R:D106	R:R:T157	2.89	1	Yes	No	5	7	1	2
L:L:T17	R:R:E89	2.82	0	No	No	0	4	0	1
L:L:W19	R:R:G264	2.81	0	Yes	No	0	4	0	1
L:L:W19	R:R:I280	2.35	0	Yes	No	0	4	0	1
R:R:E89	R:R:G88	1.64	0	No	No	4	3	1	2
R:R:G184	R:R:R190	1.5	0	No	Yes	3	5	2	1
R:R:D281	R:R:V284	1.46	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T6U_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.96
Number of Linked Nodes	293
Number of Links	328
Number of Hubs	49
Number of Links mediated by Hubs	185
Number of Communities	11
Number of Nodes involved in Communities	57
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	117
Number Of Links MetaPath	116
Number of Shortest Paths	70736
Length Of Smallest Path	3
Average Path Length	13.6289
Length of Longest Path	32
Minimum Path Strength	1.23
Average Path Strength	6.00434
Maximum Path Strength	18.54
Minimum Path Correlation	0.7
Average Path Correlation	0.928557
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	52.3845
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.4301
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • amide binding • amyloid-beta binding • binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • RAGE receptor binding • protein binding • signaling receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • negative regulation of biological process • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • response to chemical • locomotion • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of transport • regulation of phagocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • multicellular organismal process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • anatomical structure development • system development • developmental process • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell migration • cell motility • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • cellular response to chemical stimulus • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell adhesion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • defense response to other organism • positive regulation of defense response • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule membrane • specific granule • cell periphery • plasma membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	QXV
PDB Residues	L:L:?21
Environment Details	Open EMBL-EBI Page
Code	QXV
Name	D-methioninamide
Synonyms
Identifier
Formula	C5 H12 N2 O S
Molecular Weight	148.227
SMILES
PubChem	11571827
Formal Charge	0
Total Atoms	21
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>7T6U_nogp_Chain_R S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7T6U_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.