psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E89	3.49	Yes	No	2	0	4
2	L:L:?1	R:R:F110	5.35	Yes	No	0	0	7
3	L:L:?1	R:R:Y175	5.15	Yes	Yes	2	0	3
4	L:L:?1	R:R:R201	4.27	Yes	Yes	2	0	5
5	L:L:?1	R:R:R205	10.67	Yes	Yes	2	0	5
6	L:L:?1	R:R:F257	3.21	Yes	Yes	0	0	7
7	R:R:L25	R:R:V24	2.98	No	No	0	3	4
8	R:R:L25	R:R:L28	5.54	No	No	0	3	5
9	R:R:I282	R:R:R26	8.77	Yes	No	0	2	4
10	R:R:I27	R:R:V31	6.14	No	No	0	6	6
11	R:R:L30	R:R:P29	4.93	Yes	Yes	4	5	5
12	R:R:M85	R:R:P29	3.35	No	Yes	4	6	5
13	R:R:P286	R:R:P29	5.84	No	Yes	0	6	5
14	R:R:P29	R:R:S289	3.56	Yes	No	0	5	5
15	R:R:L30	R:R:M85	5.65	Yes	No	4	5	6
16	R:R:A86	R:R:L30	3.15	No	Yes	0	4	5
17	R:R:S289	R:R:V32	9.7	No	No	0	5	5
18	R:R:L33	R:R:L78	8.3	No	No	1	7	8
19	R:R:I82	R:R:L33	9.99	No	No	1	7	7
20	R:R:L39	R:R:V35	7.45	No	No	0	5	5
21	R:R:L78	R:R:T36	2.95	No	No	1	8	7
22	R:R:F293	R:R:T36	6.49	No	No	1	5	7
23	R:R:C296	R:R:T36	3.38	No	No	1	8	7
24	R:R:F37	R:R:V41	3.93	No	No	0	6	6
25	R:R:F37	R:R:P79	8.67	No	No	0	6	8
26	R:R:L39	R:R:V38	2.98	No	No	0	5	5
27	R:R:L42	R:R:V38	2.98	No	No	0	4	5
28	R:R:C296	R:R:G40	3.92	No	No	0	8	8
29	R:R:D71	R:R:N44	5.39	Yes	No	0	9	9
30	R:R:F72	R:R:N44	4.83	No	No	0	7	9
31	R:R:N44	R:R:P299	6.52	No	No	0	9	9
32	R:R:L313	R:R:L46	4.15	No	No	0	6	6
33	R:R:A68	R:R:V47	5.09	No	No	0	8	9
34	R:R:V303	R:R:V47	4.81	No	No	5	7	9
35	R:R:F309	R:R:V47	3.93	Yes	No	5	8	9
36	R:R:I48	R:R:L65	2.85	No	No	0	7	5
37	R:R:V50	R:R:W49	4.9	No	Yes	0	7	4
38	R:R:F53	R:R:W49	4.01	No	Yes	0	4	4
39	R:R:R54	R:R:W49	14.99	No	Yes	0	4	4
40	R:R:L317	R:R:W49	7.97	No	Yes	0	5	4
41	R:R:F309	R:R:V50	9.18	Yes	No	0	8	7
42	R:R:L313	R:R:V50	10.43	No	No	0	6	7
43	R:R:A51	R:R:F309	2.77	No	Yes	0	7	8
44	R:R:G52	R:R:L65	5.13	No	No	0	4	5
45	R:R:D308	R:R:M55	4.16	No	Yes	0	6	5
46	R:R:T58	R:R:T61	4.71	No	No	0	7	7
47	R:R:R137	R:R:V59	9.15	No	No	0	7	6
48	R:R:A142	R:R:V59	5.09	No	No	0	7	6
49	R:R:T60	R:R:Y64	7.49	No	No	0	7	8
50	R:R:I62	R:R:M143	2.92	No	No	0	7	4
51	R:R:C63	R:R:F118	2.79	No	No	0	7	7
52	R:R:C63	R:R:I119	4.91	No	Yes	0	7	9
53	R:R:R123	R:R:Y64	5.14	Yes	No	0	9	8
54	R:R:V303	R:R:Y64	6.31	No	No	0	7	8
55	R:R:I146	R:R:N66	7.08	No	No	0	7	9
56	R:R:D71	R:R:L67	6.79	Yes	Yes	1	9	9
57	R:R:L67	R:R:S112	3	Yes	No	1	9	9
58	R:R:L115	R:R:L67	2.77	Yes	Yes	0	8	9
59	R:R:I116	R:R:L67	5.71	No	Yes	1	8	9
60	R:R:I119	R:R:L67	2.85	Yes	Yes	1	9	9
61	R:R:L67	R:R:Y302	3.52	Yes	Yes	1	9	9
62	R:R:D71	R:R:S112	7.36	Yes	No	1	9	9
63	R:R:D71	R:R:S295	10.31	Yes	No	0	9	9
64	R:R:D71	R:R:N298	5.39	Yes	No	0	9	9
65	R:R:N108	R:R:S73	10.43	No	No	0	8	7
66	R:R:F292	R:R:F74	11.79	Yes	No	0	7	7
67	R:R:F74	R:R:S295	7.93	No	No	0	7	9
68	R:R:I101	R:R:T77	6.08	No	No	0	5	7
69	R:R:T77	R:R:V104	7.93	No	No	0	7	5
70	R:R:I82	R:R:L78	5.71	No	No	1	7	8
71	R:R:F80	R:R:I101	5.02	No	No	0	6	5
72	R:R:L81	R:R:S84	4.5	No	No	0	6	5
73	R:R:F292	R:R:L81	3.65	Yes	No	0	7	6
74	R:R:M85	R:R:N285	11.22	No	No	0	6	4
75	R:R:K90	R:R:M87	5.76	No	No	0	4	4
76	R:R:E89	R:R:Y175	24.69	No	Yes	2	4	3
77	R:R:F93	R:R:W91	14.03	Yes	Yes	2	7	9
78	R:R:G94	R:R:W91	4.22	No	Yes	0	8	9
79	R:R:C98	R:R:W91	6.53	Yes	Yes	2	9	9
80	R:R:T166	R:R:W91	20.62	No	Yes	0	5	9
81	R:R:T174	R:R:W91	6.06	Yes	Yes	0	5	9
82	R:R:F93	R:R:L97	9.74	Yes	No	0	7	7
83	R:R:C98	R:R:F93	6.98	Yes	Yes	2	9	7
84	R:R:C176	R:R:F93	4.19	Yes	Yes	2	9	7
85	R:R:F96	R:R:W95	3.01	No	No	0	1	4
86	R:R:T166	R:R:W95	6.06	No	No	0	5	4
87	R:R:F96	R:R:K99	9.93	No	Yes	7	1	7
88	R:R:F96	R:R:L100	7.31	No	No	7	1	5
89	R:R:I101	R:R:L97	8.56	No	No	0	5	7
90	R:R:C98	R:R:H102	2.95	Yes	No	2	9	6
91	R:R:C176	R:R:C98	3.64	Yes	Yes	2	9	9
92	R:R:K99	R:R:L100	4.23	Yes	No	7	7	5
93	R:R:I103	R:R:K99	5.82	No	Yes	0	5	7
94	R:R:F161	R:R:K99	8.69	No	Yes	0	4	7
95	R:R:H102	R:R:L164	6.43	No	No	0	6	5
96	R:R:C176	R:R:H102	5.9	Yes	No	2	9	6
97	R:R:I103	R:R:V160	3.07	No	Yes	0	5	4
98	R:R:N108	R:R:V104	4.43	No	No	0	8	5
99	R:R:D106	R:R:F110	8.36	No	No	0	5	7
100	R:R:D106	R:R:T157	10.12	No	No	8	5	7
101	R:R:D106	R:R:V160	4.38	No	Yes	8	5	4
102	R:R:I107	R:R:N108	4.25	Yes	No	0	5	8
103	R:R:I107	R:R:L154	4.28	Yes	No	0	5	4
104	R:R:I107	R:R:T157	4.56	Yes	No	0	5	7
105	R:R:L109	R:R:W254	5.69	No	Yes	0	8	9
106	R:R:F292	R:R:L109	3.65	Yes	No	0	7	8
107	R:R:P213	R:R:V113	3.53	No	No	0	9	7
108	R:R:V113	R:R:W254	3.68	No	Yes	0	7	9
109	R:R:F114	R:R:L152	7.31	No	No	0	6	4
110	R:R:I146	R:R:L115	2.85	No	Yes	0	7	8
111	R:R:L115	R:R:W150	3.42	Yes	No	0	8	9
112	R:R:I116	R:R:N298	5.66	No	No	0	8	9
113	R:R:I116	R:R:Y302	8.46	No	Yes	1	8	9
114	R:R:F118	R:R:I146	5.02	No	No	0	7	7
115	R:R:I119	R:R:R123	5.01	Yes	Yes	1	9	9
116	R:R:I119	R:R:Y302	3.63	Yes	Yes	1	9	9
117	R:R:A120	R:R:Y221	4	No	Yes	0	9	8
118	R:R:C126	R:R:D122	4.67	No	No	6	8	8
119	R:R:D122	R:R:R137	10.72	No	No	6	8	7
120	R:R:R123	R:R:Y221	8.23	Yes	Yes	1	9	8
121	R:R:R123	R:R:Y302	6.17	Yes	Yes	1	9	9
122	R:R:C124	R:R:L128	3.17	No	Yes	0	8	7
123	R:R:C124	R:R:C220	7.28	No	No	0	8	7
124	R:R:A133	R:R:C126	3.61	No	No	0	5	8
125	R:R:C126	R:R:R137	6.96	No	No	6	8	7
126	R:R:I224	R:R:V127	4.61	Yes	No	0	8	8
127	R:R:L128	R:R:L223	4.15	Yes	No	0	7	3
128	R:R:K227	R:R:L128	4.23	No	Yes	0	5	7
129	R:R:H136	R:R:W132	14.81	No	No	0	3	5
130	R:R:H136	R:R:N135	5.1	No	No	0	3	4
131	R:R:S140	R:R:T138	4.8	No	No	0	4	6
132	R:R:L141	R:R:V145	2.98	No	No	0	3	5
133	R:R:G148	R:R:P149	4.06	No	No	0	3	7
134	R:R:L152	R:R:L156	4.15	No	Yes	0	4	5
135	R:R:I204	R:R:L156	4.28	No	Yes	0	4	5
136	R:R:T157	R:R:V160	4.76	No	Yes	8	7	4
137	R:R:L164	R:R:V160	4.47	No	Yes	0	5	4
138	R:R:F163	R:R:L162	3.65	Yes	No	0	5	5
139	R:R:F163	R:R:F178	4.29	Yes	Yes	2	5	4
140	R:R:F163	R:R:F180	8.57	Yes	Yes	2	5	6
141	R:R:F163	R:R:M197	12.44	Yes	No	0	5	1
142	R:R:F178	R:R:L164	6.09	Yes	No	0	4	5
143	R:R:N179	R:R:T165	11.7	No	No	0	3	4
144	R:R:N179	R:R:V167	4.43	No	No	0	3	1
145	R:R:T168	R:R:T174	6.28	No	Yes	0	2	5
146	R:R:I169	R:R:P170	6.77	No	No	0	1	3
147	R:R:I169	R:R:N171	7.08	No	No	0	1	4
148	R:R:C176	R:R:Y175	5.38	Yes	Yes	2	9	3
149	R:R:T177	R:R:Y175	6.24	No	Yes	0	3	3
150	R:R:F178	R:R:F180	3.22	Yes	Yes	2	4	6
151	R:R:F178	R:R:L198	3.65	Yes	No	0	4	4
152	R:R:F178	R:R:R201	8.55	Yes	Yes	2	4	5
153	R:R:F180	R:R:R190	4.28	Yes	No	0	6	5
154	R:R:A194	R:R:F180	5.55	No	Yes	0	3	6
155	R:R:S182	R:R:W183	3.71	No	No	0	7	4
156	R:R:G184	R:R:R190	4.5	No	No	0	3	5
157	R:R:P187	R:R:T186	3.5	No	No	0	5	6
158	R:R:E188	R:R:T186	2.82	No	No	0	3	6
159	R:R:E189	R:R:T186	9.88	No	No	0	3	6
160	R:R:F273	R:R:L191	6.09	No	No	0	5	1
161	R:R:I195	R:R:T199	3.04	Yes	No	0	1	3
162	R:R:L198	R:R:L268	2.77	No	No	0	4	3
163	R:R:R201	R:R:R205	4.26	Yes	Yes	2	5	5
164	R:R:G202	R:R:T265	5.46	No	No	0	4	4
165	R:R:Q258	R:R:R205	7.01	Yes	Yes	0	8	5
166	R:R:A261	R:R:R205	4.15	No	Yes	0	5	5
167	R:R:F206	R:R:S211	3.96	No	No	0	6	4
168	R:R:F206	R:R:Q258	4.68	No	Yes	0	6	8
169	R:R:F206	R:R:L262	20.7	No	No	0	6	5
170	R:R:I208	R:R:V207	10.75	No	No	0	5	4
171	R:R:G209	R:R:P213	4.06	No	No	0	6	9
172	R:R:F210	R:R:M214	6.22	No	No	0	9	6
173	R:R:F210	R:R:F255	7.5	No	Yes	0	9	6
174	R:R:F210	R:R:Q258	10.54	No	Yes	0	9	8
175	R:R:L212	R:R:P213	3.28	No	No	0	5	9
176	R:R:I216	R:R:L212	2.85	No	No	0	6	5
177	R:R:F250	R:R:M214	6.22	No	No	0	9	6
178	R:R:F251	R:R:M214	9.95	No	No	0	6	6
179	R:R:I216	R:R:S215	4.64	No	No	0	6	3
180	R:R:I224	R:R:Y221	3.63	Yes	Yes	1	8	8
181	R:R:L243	R:R:Y221	9.38	No	Yes	1	8	8
182	R:R:V246	R:R:Y221	6.31	No	Yes	1	8	8
183	R:R:V247	R:R:Y221	3.79	No	Yes	0	8	8
184	R:R:Y221	R:R:Y302	2.98	Yes	Yes	1	8	9
185	R:R:I224	R:R:L243	2.85	Yes	No	1	8	8
186	R:R:A225	R:R:L243	3.15	No	No	0	5	8
187	R:R:I228	R:R:M233	4.37	No	No	0	8	3
188	R:R:I228	R:R:P239	3.39	No	No	0	8	7
189	R:R:K231	R:R:M233	4.32	No	No	0	5	3
190	R:R:G232	R:R:M233	5.24	No	No	0	4	3
191	R:R:S236	R:R:S237	3.26	No	No	0	6	4
192	R:R:R238	R:R:V305	3.92	Yes	No	0	7	7
193	R:R:Q307	R:R:R238	4.67	No	Yes	0	5	7
194	R:R:R241	R:R:V242	3.92	No	No	0	5	8
195	R:R:L301	R:R:V246	2.98	Yes	No	1	8	8
196	R:R:V246	R:R:Y302	5.05	No	Yes	1	8	9
197	R:R:L297	R:R:S249	6.01	No	No	1	6	7
198	R:R:L301	R:R:S249	3	Yes	No	1	8	7
199	R:R:F250	R:R:W254	5.01	No	Yes	0	9	9
200	R:R:F251	R:R:F255	9.65	No	Yes	0	6	6
201	R:R:C253	R:R:L290	4.76	No	No	0	8	8
202	R:R:C253	R:R:N294	3.15	No	No	0	8	9
203	R:R:F257	R:R:W254	4.01	Yes	Yes	0	7	9
204	R:R:Q258	R:R:W254	3.29	Yes	Yes	0	8	9
205	R:R:N294	R:R:W254	7.91	No	Yes	0	9	9
206	R:R:F255	R:R:P256	4.33	Yes	No	0	6	9
207	R:R:F255	R:R:L259	8.53	Yes	No	0	6	5
208	R:R:A291	R:R:F257	5.55	No	Yes	0	8	7
209	R:R:L259	R:R:L263	2.77	No	No	0	5	5
210	R:R:I280	R:R:V260	3.07	Yes	No	0	4	5
211	R:R:T287	R:R:V260	4.76	No	No	0	7	5
212	R:R:I280	R:R:L263	2.85	Yes	No	0	4	5
213	R:R:V266	R:R:W267	6.13	No	No	0	4	3
214	R:R:W267	R:R:Y277	7.72	No	No	0	3	3
215	R:R:L268	R:R:L272	4.15	No	No	0	3	3
216	R:R:E270	R:R:K269	4.05	No	No	0	2	4
217	R:R:F273	R:R:K269	13.65	No	No	0	5	4
218	R:R:L272	R:R:M271	2.83	No	No	0	3	1
219	R:R:D281	R:R:M271	2.77	No	No	0	4	1
220	R:R:F273	R:R:Y274	3.09	No	No	0	5	5
221	R:R:I279	R:R:Y277	10.88	No	No	0	3	3
222	R:R:I280	R:R:Y277	8.46	Yes	No	0	4	3
223	R:R:D281	R:R:K278	12.44	No	No	3	4	1
224	R:R:I282	R:R:K278	13.09	Yes	No	3	2	1
225	R:R:I279	R:R:I282	4.42	No	Yes	3	3	2
226	R:R:I279	R:R:L283	4.28	No	No	3	3	6
227	R:R:D281	R:R:I282	7	No	Yes	3	4	2
228	R:R:I282	R:R:L283	4.28	Yes	No	3	2	6
229	R:R:N285	R:R:S288	2.98	No	No	0	4	6
230	R:R:C296	R:R:F293	2.79	No	No	1	8	5
231	R:R:F293	R:R:L297	3.65	No	No	1	5	6
232	R:R:N294	R:R:N298	12.26	No	No	0	9	9
233	R:R:L297	R:R:L301	2.77	No	Yes	1	6	8
234	R:R:M300	R:R:P299	3.35	No	No	0	7	9
235	R:R:F304	R:R:M300	8.71	No	No	0	7	7
236	R:R:F309	R:R:V303	9.18	Yes	No	5	8	7
237	R:R:F304	R:R:F309	6.43	No	Yes	0	7	8
238	R:R:Q307	R:R:R310	7.01	No	No	0	5	8
239	R:R:E270	R:R:K276	2.7	No	No	0	2	1
240	R:R:R54	R:R:S316	2.64	No	No	0	4	5
241	R:R:R238	R:R:S236	2.64	Yes	No	0	7	6
242	R:R:F257	R:R:S288	2.64	Yes	No	0	7	6
243	R:R:F292	R:R:S288	2.64	Yes	No	0	7	6
244	R:R:F37	R:R:V38	2.62	No	No	0	6	5
245	R:R:F72	R:R:V41	2.62	No	No	0	7	6
246	R:R:F74	R:R:V105	2.62	No	No	0	7	6
247	R:R:F118	R:R:V145	2.62	No	No	0	7	5
248	R:R:D308	R:R:E311	2.6	No	No	0	6	4
249	R:R:A70	R:R:W150	2.59	No	No	0	8	9
250	R:R:F72	R:R:T75	2.59	No	No	0	7	7
251	R:R:V217	R:R:Y221	2.52	No	Yes	0	8	8
252	R:R:F114	R:R:I208	2.51	No	No	0	6	5
253	R:R:M55	R:R:R312	2.48	Yes	No	0	5	5
254	R:R:F110	R:R:L156	2.44	No	Yes	0	7	5
255	R:R:T165	R:R:W95	2.43	No	No	0	4	4
256	R:R:I125	R:R:W132	2.35	No	No	0	5	5
257	R:R:L69	R:R:W150	2.28	No	No	0	6	9
258	R:R:G184	R:R:G185	2.11	No	No	0	3	3
259	R:R:A153	R:R:G111	1.95	No	No	0	8	7
260	R:R:A225	R:R:G222	1.95	No	No	0	5	3
261	R:R:G117	R:R:V217	1.84	No	No	0	7	8
262	R:R:G148	R:R:V147	1.84	No	No	0	3	4
263	R:R:P92	R:R:V83	1.77	No	No	0	3	5
264	R:R:G45	R:R:I48	1.76	No	No	0	4	7
265	R:R:G232	R:R:I234	1.76	No	No	0	4	4
266	R:R:G264	R:R:I280	1.76	No	Yes	0	4	4
267	R:R:G43	R:R:M300	1.75	No	No	0	8	7
268	R:R:G275	R:R:M271	1.75	No	No	0	1	1
269	R:R:A51	R:R:T61	1.68	No	No	0	7	7
270	R:R:M87	R:R:P92	1.68	No	No	0	4	3
271	R:R:L28	R:R:P29	1.64	No	Yes	0	5	5
272	R:R:L115	R:R:P149	1.64	Yes	No	0	8	7
273	R:R:C124	R:R:I224	1.64	No	Yes	0	8	8
274	R:R:L158	R:R:P159	1.64	No	No	0	4	8
275	R:R:C220	R:R:I216	1.64	No	No	0	7	6
276	R:R:C253	R:R:I252	1.64	No	No	0	8	6
277	R:R:A142	R:R:I62	1.62	No	No	0	7	7
278	R:R:A153	R:R:I107	1.62	No	Yes	0	8	5
279	R:R:A133	R:R:I125	1.62	No	No	0	5	5
280	R:R:V242	R:R:V305	1.6	No	No	0	8	7
281	R:R:C220	R:R:L121	1.59	No	No	0	7	7
282	R:R:A245	R:R:L301	1.58	No	Yes	0	6	8
283	R:R:I62	R:R:V139	1.54	No	No	0	7	3
284	R:R:I151	R:R:V147	1.54	No	No	0	3	4
285	R:R:H129	R:R:P130	1.53	No	No	0	6	8
286	R:R:K144	R:R:V145	1.52	No	No	0	1	5
287	R:R:I169	R:R:T174	1.52	No	Yes	0	1	5
288	R:R:M197	R:R:V193	1.52	No	No	0	1	4
289	R:R:I195	R:R:T196	1.52	Yes	No	0	1	1
290	R:R:M55	R:R:T56	1.51	Yes	No	0	5	6
291	R:R:M55	R:R:T61	1.51	Yes	No	0	5	7
292	R:R:G52	R:R:R57	1.5	No	No	0	4	6
293	R:R:K90	R:R:T174	1.5	No	Yes	0	4	5
294	R:R:L141	R:R:S140	1.5	No	No	0	3	4
295	R:R:G202	R:R:R201	1.5	No	Yes	2	4	5
296	R:R:G202	R:R:R205	1.5	No	Yes	2	4	5
297	R:R:L156	R:R:V155	1.49	Yes	No	0	5	4
298	R:R:N135	R:R:V131	1.48	No	No	0	4	5
299	R:R:K227	R:R:K231	1.44	No	No	0	5	5
300	R:R:P239	R:R:R238	1.44	No	Yes	0	7	7
301	R:R:I27	R:R:L28	1.43	No	No	0	6	5
302	R:R:I27	R:R:L30	1.43	No	Yes	0	6	5
303	R:R:I48	R:R:L69	1.43	No	No	0	7	6
304	R:R:I195	R:R:L191	1.43	Yes	No	0	1	1
305	R:R:I195	R:R:L268	1.43	Yes	No	0	1	3
306	R:R:I219	R:R:L223	1.43	No	No	0	3	3
307	R:R:E189	R:R:K192	1.35	No	No	0	3	5
308	L:L:?1	R:R:V284	1.31	Yes	No	0	0	5
309	R:R:R57	R:R:V139	1.31	No	No	0	6	3
310	R:R:H129	R:R:L128	1.29	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	4.77857	7	2	0
2	R:R:P29	3.864	5	4	5
3	R:R:L30	3.79	4	4	5
4	R:R:W49	7.9675	4	0	4
5	R:R:M55	2.415	4	0	5
6	R:R:L67	4.10667	6	1	9
7	R:R:D71	7.048	5	1	9
8	R:R:W91	10.292	5	2	9
9	R:R:F93	8.735	4	2	7
10	R:R:C98	5.025	4	2	9
11	R:R:K99	7.1675	4	7	7
12	R:R:I107	3.6775	4	0	5
13	R:R:L115	2.67	4	0	8
14	R:R:I119	4.1	4	1	9
15	R:R:R123	6.1375	4	1	9
16	R:R:L128	3.21	4	0	7
17	R:R:L156	3.09	4	0	5
18	R:R:V160	4.17	4	8	4
19	R:R:F163	7.2375	4	2	5
20	R:R:T174	3.84	4	0	5
21	R:R:Y175	10.365	4	2	3
22	R:R:C176	4.7775	4	2	9
23	R:R:F178	5.16	5	2	4
24	R:R:F180	5.405	4	2	6
25	R:R:I195	1.855	4	0	1
26	R:R:R201	4.645	4	2	5
27	R:R:R205	5.518	5	2	5
28	R:R:Y221	5.105	8	1	8
29	R:R:I224	3.1825	4	1	8
30	R:R:R238	3.1675	4	0	7
31	R:R:W254	4.93167	6	0	9
32	R:R:F255	7.5025	4	0	6
33	R:R:F257	3.8525	4	0	7
34	R:R:Q258	6.38	4	0	8
35	R:R:I280	4.035	4	0	4
36	R:R:I282	7.512	5	3	2
37	R:R:F292	5.4325	4	0	7
38	R:R:L301	2.5825	4	1	8
39	R:R:Y302	4.96833	6	1	9
40	R:R:F309	6.298	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F257	77.305	3.21	Yes	Yes	0	0	7
2	R:R:F257	R:R:S288	11.3475	2.64	Yes	No	0	7	6
3	R:R:N285	R:R:S288	13.9313	2.98	No	No	0	4	6
4	R:R:M85	R:R:N285	12.8916	11.22	No	No	0	6	4
5	L:L:?1	R:R:R201	24.3146	4.27	Yes	Yes	2	0	5
6	R:R:F178	R:R:R201	44.6557	8.55	Yes	Yes	2	4	5
7	R:R:F178	R:R:L198	30.7449	3.65	Yes	No	0	4	4
8	R:R:L198	R:R:L268	29.0087	2.77	No	No	0	4	3
9	R:R:L268	R:R:L272	11.3166	4.15	No	No	0	3	3
10	R:R:F257	R:R:W254	75.2256	4.01	Yes	Yes	0	7	9
11	R:R:N294	R:R:W254	99.7529	7.91	No	Yes	0	9	9
12	R:R:N294	R:R:N298	100	12.26	No	No	0	9	9
13	R:R:I116	R:R:N298	56.7443	5.66	No	No	0	8	9
14	R:R:I116	R:R:Y302	31.7126	8.46	No	Yes	1	8	9
15	R:R:V246	R:R:Y302	11.2823	5.05	No	Yes	1	8	9
16	R:R:L301	R:R:V246	12.7921	2.98	Yes	No	1	8	8
17	R:R:D71	R:R:N298	43.4718	5.39	Yes	No	0	9	9
18	R:R:D71	R:R:N44	24.6063	5.39	Yes	No	0	9	9
19	R:R:N44	R:R:P299	15.4788	6.52	No	No	0	9	9
20	R:R:M300	R:R:P299	14.5489	3.35	No	No	0	7	9
21	R:R:F304	R:R:M300	12.9293	8.71	No	No	0	7	7
22	R:R:F304	R:R:F309	12.449	6.43	No	Yes	0	7	8
23	R:R:F309	R:R:V50	14.1612	9.18	Yes	No	0	8	7
24	R:R:R123	R:R:Y302	17.1739	6.17	Yes	Yes	1	9	9
25	R:R:R123	R:R:Y64	24.1911	5.14	Yes	No	0	9	8
26	R:R:V303	R:R:Y64	21.8852	6.31	No	No	0	7	8
27	R:R:F309	R:R:V303	18.296	9.18	Yes	No	5	8	7
28	R:R:D71	R:R:L67	35.3601	6.79	Yes	Yes	1	9	9
29	R:R:L115	R:R:L67	53.3576	2.77	Yes	Yes	0	8	9
30	R:R:L115	R:R:W150	35.693	3.42	Yes	No	0	8	9
31	R:R:L69	R:R:W150	32.5361	2.28	No	No	0	6	9
32	R:R:I48	R:R:L69	30.9474	1.43	No	No	0	7	6
33	R:R:I116	R:R:L67	24.7984	5.71	No	Yes	1	8	9
34	R:R:I48	R:R:L65	27.7494	2.85	No	No	0	7	5
35	R:R:A51	R:R:F309	14.0789	2.77	No	Yes	0	7	8
36	R:R:G52	R:R:L65	26.1401	5.13	No	No	0	4	5
37	R:R:A51	R:R:T61	12.4146	1.68	No	No	0	7	7
38	R:R:G52	R:R:R57	24.5239	1.5	No	No	0	4	6
39	R:R:R57	R:R:V139	22.9009	1.31	No	No	0	6	3
40	R:R:I62	R:R:V139	21.271	1.54	No	No	0	7	3
41	R:R:A142	R:R:I62	17.9906	1.62	No	No	0	7	7
42	R:R:A142	R:R:V59	16.3401	5.09	No	No	0	7	6
43	R:R:I119	R:R:L67	13.0529	2.85	Yes	Yes	1	9	9
44	R:R:C63	R:R:I119	15.2524	4.91	No	Yes	0	7	9
45	R:R:I146	R:R:L115	11.5568	2.85	No	Yes	0	7	8
46	R:R:C63	R:R:F118	13.2039	2.79	No	No	0	7	7
47	L:L:?1	R:R:F110	22.5028	5.35	Yes	No	0	0	7
48	R:R:D106	R:R:F110	14.1372	8.36	No	No	0	5	7
49	L:L:?1	R:R:Y175	38.7983	5.15	Yes	Yes	2	0	3
50	R:R:C176	R:R:Y175	37.2405	5.38	Yes	Yes	2	9	3
51	R:R:C176	R:R:F93	20.293	4.19	Yes	Yes	2	9	7
52	R:R:F93	R:R:W91	15.4068	14.03	Yes	Yes	2	7	9
53	R:R:T174	R:R:W91	18.7558	6.06	Yes	Yes	0	5	9
54	R:R:C176	R:R:C98	15.8837	3.64	Yes	Yes	2	9	9
55	R:R:C98	R:R:W91	17.3695	6.53	Yes	Yes	2	9	9
56	R:R:T166	R:R:W91	10.5892	20.62	No	Yes	0	5	9
57	R:R:V113	R:R:W254	19.2979	3.68	No	Yes	0	7	9
58	R:R:P213	R:R:V113	18.1896	3.53	No	No	0	9	7
59	R:R:Y221	R:R:Y302	13.8524	2.98	Yes	Yes	1	8	9
60	R:R:L212	R:R:P213	16.2818	3.28	No	No	0	5	9
61	R:R:I216	R:R:L212	15.7877	2.85	No	No	0	6	5
62	R:R:C220	R:R:I216	15.3416	1.64	No	No	0	7	6
63	R:R:C124	R:R:C220	15.0053	7.28	No	No	0	8	7
64	R:R:C124	R:R:L128	20.5435	3.17	No	Yes	0	8	7
65	R:R:R137	R:R:V59	14.6759	9.15	No	No	0	7	6
66	R:R:C126	R:R:R137	11.6803	6.96	No	No	6	8	7
67	R:R:A133	R:R:C126	10.2083	3.61	No	No	0	5	8
68	R:R:I224	R:R:Y221	12.3494	3.63	Yes	Yes	1	8	8
69	R:R:F118	R:R:V145	17.5342	2.62	No	No	0	7	5
70	R:R:L141	R:R:V145	10.7024	2.98	No	No	0	3	5
71	R:R:I195	R:R:L268	17.1568	1.43	Yes	No	0	1	3
72	R:R:I195	R:R:L191	11.5019	1.43	Yes	No	0	1	1
73	R:R:Q258	R:R:R205	29.3964	7.01	Yes	Yes	0	8	5
74	R:R:F210	R:R:Q258	18.5842	10.54	No	Yes	0	9	8
75	R:R:F210	R:R:F255	16.8411	7.5	No	Yes	0	9	6
76	R:R:K227	R:R:L128	15.5749	4.23	No	Yes	0	5	7
77	R:R:K227	R:R:K231	14.645	1.44	No	No	0	5	5
78	R:R:K231	R:R:M233	13.6259	4.32	No	No	0	5	3
79	R:R:I228	R:R:M233	10.5274	4.37	No	No	0	8	3
80	R:R:F255	R:R:L259	14.3808	8.53	Yes	No	0	6	5
81	R:R:L259	R:R:L263	13.2416	2.77	No	No	0	5	5
82	R:R:I280	R:R:L263	12.1642	2.85	Yes	No	0	4	5
83	R:R:Q258	R:R:W254	39.8929	3.29	Yes	Yes	0	8	9
84	R:R:R201	R:R:R205	21.9504	4.26	Yes	Yes	2	5	5
85	R:R:L67	R:R:Y302	12.37	3.52	Yes	Yes	1	9	9
86	R:R:C124	R:R:I224	10.9117	1.64	No	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:E89	3.49	2	Yes	No	0	4	0	1
L:L:?1	R:R:F110	5.35	2	Yes	No	0	7	0	1
L:L:?1	R:R:Y175	5.15	2	Yes	Yes	0	3	0	1
L:L:?1	R:R:R201	4.27	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:R205	10.67	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:F257	3.21	2	Yes	Yes	0	7	0	1
R:R:E89	R:R:Y175	24.69	2	No	Yes	4	3	1	1
R:R:D106	R:R:F110	8.36	8	No	No	5	7	2	1
R:R:C176	R:R:Y175	5.38	2	Yes	Yes	9	3	2	1
R:R:T177	R:R:Y175	6.24	0	No	Yes	3	3	2	1
R:R:F178	R:R:R201	8.55	2	Yes	Yes	4	5	2	1
R:R:R201	R:R:R205	4.26	2	Yes	Yes	5	5	1	1
R:R:Q258	R:R:R205	7.01	0	Yes	Yes	8	5	2	1
R:R:A261	R:R:R205	4.15	0	No	Yes	5	5	2	1
R:R:F257	R:R:W254	4.01	0	Yes	Yes	7	9	1	2
R:R:Q258	R:R:W254	3.29	0	Yes	Yes	8	9	2	2
R:R:A291	R:R:F257	5.55	0	No	Yes	8	7	2	1
R:R:F257	R:R:S288	2.64	0	Yes	No	7	6	1	2
R:R:F110	R:R:L156	2.44	0	No	Yes	7	5	1	2
R:R:G202	R:R:R201	1.5	2	No	Yes	4	5	2	1
R:R:G202	R:R:R205	1.5	2	No	Yes	4	5	2	1
L:L:?1	R:R:V284	1.31	2	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y62_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	275
Number of Links	310
Number of Hubs	40
Number of Links mediated by Hubs	150
Number of Communities	8
Number of Nodes involved in Communities	54
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	57486
Length Of Smallest Path	3
Average Path Length	14.5216
Length of Longest Path	36
Minimum Path Strength	1.405
Average Path Strength	5.22807
Maximum Path Strength	17.325
Minimum Path Correlation	0.7
Average Path Correlation	0.931513
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	49.1434
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.6287
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • molecular transducer activity • signaling receptor activity • amide binding • amyloid-beta binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • RAGE receptor binding • signaling receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • negative regulation of biological process • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • locomotion • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of transport • regulation of phagocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell migration • cell motility • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • cell adhesion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • defense response to other organism • positive regulation of defense response • cellular response to amyloid-beta • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • tertiary granule membrane • intracellular vesicle • tertiary granule • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule membrane • specific granule • ficolin-1-rich granule membrane • ficolin-1-rich granule • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	16C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	16C
Name	N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE
Synonyms	C16-CERAMIDE; N-PALMITOYL-D-ERYTHRO-SPHINGOSINE; (2S,3R,4E)-2-PALMITOYLAMINOOCTADEC-4-ENE-1,3-DIOL; (2S,3R,4E)-2-PALMITOYLAMINO-1,3-OCTADEC-4-ENEDIOL
Identifier
Formula	C34 H67 N O3
Molecular Weight	537.901
SMILES
PubChem	5283564
Formal Charge	0
Total Atoms	105
Total Chiral Atoms	2
Total Bonds	104
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>8Y62_nogp_Chain_R V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	PubChem 24776341	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188

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