psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y31	R:R:Y32	10.92	No	Yes	0	4	5
2	R:R:S35	R:R:Y31	5.09	No	No	0	4	4
3	R:R:S366	R:R:Y32	5.09	No	Yes	0	6	5
4	R:R:W370	R:R:Y32	7.72	Yes	Yes	0	8	5
5	R:R:S35	R:R:W370	4.94	No	Yes	0	4	8
6	R:R:V86	R:R:Y36	8.83	No	Yes	0	8	7
7	R:R:E90	R:R:Y36	8.98	No	Yes	0	6	7
8	R:R:W370	R:R:Y36	7.72	Yes	Yes	0	8	7
9	R:R:L39	R:R:W370	7.97	No	Yes	0	7	8
10	R:R:I40	R:R:M83	5.83	No	No	0	7	8
11	R:R:A79	R:R:I43	4.87	No	No	0	8	8
12	R:R:I43	R:R:S376	4.64	No	No	0	8	9
13	R:R:L76	R:R:V44	4.47	No	No	0	8	6
14	R:R:F45	R:R:L49	8.53	No	No	0	5	7
15	R:R:A72	R:R:N47	4.69	No	Yes	0	9	9
16	R:R:D75	R:R:N47	13.46	Yes	Yes	0	9	9
17	R:R:N47	R:R:P380	11.4	Yes	No	0	9	9
18	R:R:T384	R:R:V50	6.35	No	No	0	8	9
19	R:R:I397	R:R:M52	8.75	No	No	0	7	5
20	R:R:V54	R:R:V69	4.81	No	No	0	8	7
21	R:R:E57	R:R:L60	7.95	No	No	0	8	9
22	R:R:A393	R:R:E57	4.53	No	No	0	8	8
23	R:R:Q61	R:R:R58	7.01	No	No	0	8	7
24	R:R:L60	R:R:N65	5.49	No	Yes	2	9	9
25	R:R:F390	R:R:L60	14.61	Yes	No	2	9	9
26	R:R:T62	R:R:T64	10.99	No	No	2	7	8
27	R:R:N65	R:R:T62	7.31	Yes	No	2	9	7
28	R:R:S146	R:R:T63	9.59	No	No	0	8	6
29	R:R:T63	R:R:V150	9.52	No	Yes	0	6	7
30	R:R:N65	R:R:T64	7.31	Yes	No	2	9	8
31	R:R:T64	R:R:Y138	7.49	No	No	0	8	8
32	R:R:F390	R:R:N65	12.08	Yes	Yes	2	9	9
33	R:R:D127	R:R:L67	5.43	No	Yes	0	9	7
34	R:R:L67	R:R:V150	8.94	Yes	Yes	4	7	7
35	R:R:L67	R:R:M153	5.65	Yes	No	4	7	6
36	R:R:I154	R:R:L67	5.71	No	Yes	0	8	7
37	R:R:N120	R:R:S70	8.94	No	No	0	9	9
38	R:R:I154	R:R:S70	10.84	No	No	0	8	9
39	R:R:S70	R:R:W158	6.18	No	Yes	0	9	9
40	R:R:L71	R:R:N120	5.49	No	No	0	9	9
41	R:R:L71	R:R:N379	12.36	No	No	0	9	9
42	R:R:L71	R:R:Y383	4.69	No	Yes	0	9	9
43	R:R:D75	R:R:S117	5.89	Yes	No	0	9	9
44	R:R:D75	R:R:S376	11.78	Yes	No	0	9	9
45	R:R:D75	R:R:N379	10.77	Yes	No	0	9	9
46	R:R:L77	R:R:M113	9.9	No	No	0	6	5
47	R:R:S376	R:R:V78	4.85	No	No	0	9	8
48	R:R:L81	R:R:T80	4.42	No	No	0	6	5
49	R:R:D110	R:R:V82	5.84	Yes	No	0	8	8
50	R:R:M83	R:R:Y373	10.78	No	Yes	0	8	8
51	R:R:W85	R:R:W96	5.62	No	Yes	3	7	9
52	R:R:F106	R:R:W85	18.04	No	No	3	7	7
53	R:R:V86	R:R:Y373	7.57	No	Yes	0	8	8
54	R:R:F98	R:R:W96	12.03	No	Yes	0	6	9
55	R:R:C103	R:R:W96	5.22	No	Yes	3	9	9
56	R:R:F106	R:R:W96	8.02	No	Yes	3	7	9
57	R:R:C181	R:R:W96	15.67	No	Yes	3	9	9
58	R:R:I101	R:R:S99	6.19	No	No	0	4	7
59	R:R:C103	R:R:R100	5.57	No	No	0	9	3
60	R:R:R100	R:R:T175	9.06	No	No	0	3	4
61	R:R:P178	R:R:R100	11.53	No	No	0	4	3
62	R:R:C103	R:R:C181	7.28	No	No	3	9	9
63	R:R:D104	R:R:N173	8.08	No	Yes	0	6	5
64	R:R:L168	R:R:V107	5.96	Yes	No	6	7	7
65	R:R:N173	R:R:V107	10.35	Yes	No	6	5	7
66	R:R:L169	R:R:T108	10.32	No	No	0	7	7
67	R:R:C114	R:R:D110	4.67	No	Yes	1	7	8
68	R:R:D110	R:R:Y373	9.2	Yes	Yes	1	8	8
69	L:L:?1	R:R:D110	17.64	Yes	Yes	1	0	8
70	R:R:L168	R:R:V111	4.47	Yes	No	0	7	8
71	L:L:?1	R:R:V111	12.59	Yes	No	0	0	8
72	R:R:M112	R:R:M113	7.22	No	No	0	7	5
73	R:R:F162	R:R:M112	6.22	No	No	0	6	7
74	R:R:M112	R:R:S165	6.13	No	No	0	7	8
75	R:R:C114	R:R:W342	5.22	No	Yes	0	7	8
76	L:L:?1	R:R:C114	5.16	Yes	No	1	0	7
77	R:R:S196	R:R:T115	9.59	No	No	0	8	8
78	R:R:A116	R:R:W158	7.78	No	Yes	0	8	9
79	R:R:I118	R:R:W342	16.44	No	Yes	0	9	8
80	R:R:L119	R:R:V157	4.47	No	Yes	0	7	7
81	R:R:L119	R:R:L160	5.54	No	No	0	7	5
82	R:R:N120	R:R:V157	8.87	No	Yes	0	9	7
83	R:R:F338	R:R:L121	6.09	Yes	No	0	9	8
84	R:R:L121	R:R:Y383	7.03	No	Yes	0	8	9
85	R:R:C122	R:R:T204	5.07	No	No	0	7	8
86	R:R:I124	R:R:R128	6.26	No	No	5	9	9
87	R:R:I124	R:R:Y383	7.25	No	Yes	5	9	9
88	R:R:S125	R:R:T204	6.4	No	No	0	9	8
89	R:R:S125	R:R:V207	8.08	No	No	0	9	7
90	R:R:S125	R:R:Y208	8.9	No	Yes	0	9	9
91	R:R:D127	R:R:Y138	11.49	No	No	0	9	8
92	R:R:D127	R:R:R149	8.34	No	No	0	9	7
93	R:R:R128	R:R:Y208	10.29	No	Yes	0	9	9
94	R:R:R128	R:R:Y383	6.17	No	Yes	5	9	9
95	R:R:V133	R:R:Y129	16.4	No	No	0	7	9
96	R:R:R149	R:R:T130	11.64	No	No	0	7	5
97	R:R:A131	R:R:Y138	9.34	No	No	0	8	8
98	R:R:L215	R:R:V132	4.47	No	No	0	8	8
99	R:R:H137	R:R:M134	5.25	No	No	0	5	6
100	R:R:H137	R:R:S145	6.97	No	No	0	5	7
101	R:R:H137	R:R:R149	5.64	No	No	0	5	7
102	R:R:M153	R:R:V150	4.56	No	Yes	4	6	7
103	R:R:V157	R:R:W158	4.9	Yes	Yes	0	7	9
104	R:R:L160	R:R:V195	4.47	No	No	0	5	4
105	R:R:C166	R:R:F162	9.78	No	No	0	6	6
106	R:R:S196	R:R:V164	4.85	No	No	0	8	7
107	R:R:C166	R:R:P167	5.65	No	No	0	6	7
108	R:R:F172	R:R:P167	5.78	No	No	0	6	7
109	R:R:F188	R:R:P167	4.33	Yes	No	0	7	7
110	R:R:L168	R:R:N173	5.49	Yes	Yes	6	7	5
111	R:R:F188	R:R:L168	13.4	Yes	Yes	0	7	7
112	R:R:N173	R:R:T175	5.85	Yes	No	0	5	4
113	R:R:N185	R:R:T174	10.24	No	No	0	6	5
114	R:R:D177	R:R:P178	8.05	No	No	0	4	4
115	R:R:D177	R:R:T179	11.56	No	No	0	4	2
116	R:R:P186	R:R:T353	5.25	No	No	0	4	6
117	R:R:F188	R:R:S192	13.21	Yes	No	0	7	8
118	R:R:H349	R:R:V189	12.45	Yes	No	0	8	7
119	R:R:T353	R:R:V189	14.28	No	No	0	6	7
120	R:R:H354	R:R:I190	9.28	No	No	0	4	6
121	L:L:?1	R:R:S192	6.83	Yes	No	0	0	8
122	R:R:F346	R:R:S193	5.28	Yes	No	0	7	8
123	R:R:F197	R:R:Y198	11.35	Yes	No	0	9	6
124	R:R:F197	R:R:F201	16.08	Yes	Yes	1	9	6
125	R:R:F197	R:R:F338	5.36	Yes	Yes	1	9	9
126	R:R:F197	R:R:L343	4.87	Yes	No	0	9	7
127	R:R:F197	R:R:F346	25.72	Yes	Yes	1	9	7
128	R:R:F201	R:R:V205	5.24	Yes	No	0	6	5
129	R:R:F201	R:R:F338	8.57	Yes	Yes	1	6	9
130	R:R:F338	R:R:T204	7.78	Yes	No	0	9	8
131	R:R:L335	R:R:V205	5.96	No	No	0	8	5
132	R:R:V331	R:R:Y208	5.05	No	Yes	0	8	9
133	R:R:V334	R:R:Y208	8.83	No	Yes	0	8	9
134	R:R:L335	R:R:Y208	7.03	No	Yes	0	8	9
135	R:R:R210	R:R:V214	7.85	No	No	0	6	7
136	R:R:K216	R:R:Y212	5.97	No	No	0	6	6
137	R:R:T328	R:R:Y212	7.49	No	No	0	8	6
138	R:R:K216	R:R:R220	11.14	No	No	0	6	6
139	R:R:P321	R:R:R219	5.76	No	No	8	5	5
140	R:R:E324	R:R:R219	6.98	No	No	8	8	5
141	R:R:E324	R:R:R222	11.63	No	No	0	8	5
142	R:R:E324	R:R:P321	12.58	No	No	8	8	5
143	R:R:F386	R:R:M330	9.95	No	No	0	7	8
144	R:R:F386	R:R:I333	5.02	No	No	0	7	8
145	R:R:V334	R:R:Y383	7.57	No	Yes	0	8	9
146	R:R:F338	R:R:W342	6.01	Yes	Yes	0	9	8
147	R:R:F346	R:R:W342	6.01	Yes	Yes	0	7	8
148	R:R:G372	R:R:W342	5.63	No	Yes	0	7	8
149	R:R:N375	R:R:W342	13.56	No	Yes	0	9	8
150	R:R:L343	R:R:L347	6.92	No	No	0	7	6
151	R:R:L371	R:R:P344	4.93	No	No	0	8	9
152	R:R:F345	R:R:F346	10.72	Yes	Yes	1	8	7
153	R:R:F345	R:R:H349	11.31	Yes	Yes	1	8	8
154	R:R:F345	R:R:Y365	8.25	Yes	No	1	8	4
155	R:R:F345	R:R:T369	5.19	Yes	No	1	8	6
156	L:L:?1	R:R:F345	18.21	Yes	Yes	1	0	8
157	L:L:?1	R:R:F346	10.29	Yes	Yes	1	0	7
158	R:R:L364	R:R:T348	7.37	No	No	0	5	6
159	R:R:T348	R:R:T368	10.99	No	No	0	6	6
160	R:R:H349	R:R:Y365	8.71	Yes	No	1	8	4
161	L:L:?1	R:R:H349	11.7	Yes	Yes	1	0	8
162	R:R:N352	R:R:V360	8.87	No	No	0	5	5
163	R:R:N352	R:R:Y365	5.81	No	No	0	5	4
164	R:R:C355	R:R:C358	7.28	No	No	9	5	4
165	R:R:T369	R:R:Y373	4.99	No	Yes	1	6	8
166	L:L:?1	R:R:T369	7.66	Yes	No	1	0	6
167	R:R:V374	R:R:W370	7.36	No	Yes	0	5	8
168	L:L:?1	R:R:Y373	16.76	Yes	Yes	1	0	8
169	R:R:N375	R:R:N379	12.26	No	No	0	9	9
170	R:R:I382	R:R:Y383	9.67	No	Yes	0	8	9
171	R:R:F390	R:R:T384	16.86	Yes	No	2	9	8
172	R:R:F394	R:R:T384	6.49	No	No	2	9	8
173	R:R:E389	R:R:N387	13.15	No	No	0	7	9
174	R:R:F390	R:R:N387	8.46	Yes	No	0	9	9
175	R:R:I388	R:R:K392	5.82	No	No	0	5	6
176	R:R:F390	R:R:F394	10.72	Yes	No	2	9	9
177	R:R:F170	R:R:F172	4.29	No	No	0	5	6
178	R:R:I183	R:R:L168	4.28	No	Yes	0	7	7
179	R:R:L109	R:R:L81	4.15	No	No	0	4	6
180	R:R:I333	R:R:Q329	4.12	No	No	0	8	7
181	R:R:G46	R:R:P380	4.06	No	No	0	9	9
182	R:R:C102	R:R:W85	3.92	No	No	3	4	7
183	R:R:C102	R:R:W96	3.92	No	Yes	3	4	9
184	L:L:?1	R:R:S196	3.9	Yes	No	0	0	8
185	R:R:F386	R:R:T385	3.89	No	No	0	7	6
186	R:R:V207	R:R:Y129	3.79	No	No	0	7	9
187	R:R:V195	R:R:Y191	3.79	No	No	0	4	6
188	R:R:C122	R:R:P200	3.77	No	No	0	7	9
189	R:R:F201	R:R:I339	3.77	Yes	No	0	6	5
190	R:R:I388	R:R:R391	3.76	No	No	0	5	9
191	R:R:V73	R:R:W158	3.68	No	Yes	0	6	9
192	R:R:G141	R:R:T62	3.64	No	No	0	4	7
193	R:R:I211	R:R:Y129	3.63	No	No	0	9	9
194	R:R:F98	R:R:N97	3.62	No	No	0	6	4
195	R:R:F188	R:R:N185	3.62	Yes	No	0	7	6
196	R:R:P362	R:R:S361	3.56	No	No	0	2	5
197	R:R:C37	R:R:V87	3.42	No	Yes	0	3	6
198	R:R:G48	R:R:L76	3.42	No	No	0	5	8
199	R:R:A74	R:R:S117	3.42	No	No	0	8	9
200	R:R:G94	R:R:L89	3.42	No	No	0	5	5
201	R:R:C122	R:R:V203	3.42	No	No	0	7	7
202	R:R:C341	R:R:V374	3.42	No	No	0	8	5
203	R:R:C358	R:R:V360	3.42	No	No	0	4	5
204	R:R:Q61	R:R:Y66	3.38	No	No	0	8	5
205	R:R:C147	R:R:T63	3.38	No	No	0	4	6
206	R:R:A161	R:R:T115	3.36	No	No	0	8	8
207	R:R:L199	R:R:P200	3.28	No	No	0	7	9
208	R:R:A337	R:R:I382	3.25	No	No	0	6	8
209	R:R:S193	R:R:V350	3.23	No	No	0	8	6
210	R:R:V132	R:R:V133	3.21	No	No	7	8	7
211	R:R:V132	R:R:V214	3.21	No	No	7	8	7
212	R:R:V133	R:R:V214	3.21	No	No	7	7	7
213	R:R:T92	R:R:V95	3.17	No	No	0	5	3
214	R:R:C355	R:R:L351	3.17	No	No	9	5	6
215	R:R:C358	R:R:L351	3.17	No	No	9	4	6
216	R:R:T385	R:R:V381	3.17	No	No	0	6	6
217	R:R:I190	R:R:V350	3.07	No	No	0	6	6
218	R:R:A59	R:R:E57	3.02	No	No	0	6	8
219	R:R:F45	R:R:G46	3.01	No	No	0	5	9
220	R:R:F201	R:R:G202	3.01	Yes	No	0	6	4
221	R:R:L109	R:R:V105	2.98	No	No	0	4	5
222	R:R:L378	R:R:V374	2.98	No	No	0	7	5
223	R:R:I333	R:R:I382	2.94	No	No	0	8	8
224	R:R:I126	R:R:M153	2.92	No	No	0	6	6
225	R:R:I397	R:R:K56	2.91	No	No	0	7	5
226	R:R:Q139	R:R:V136	2.87	No	No	0	6	6
227	R:R:I397	R:R:L49	2.85	No	No	0	7	7
228	R:R:A53	R:R:F390	2.77	No	Yes	2	9	9
229	R:R:A53	R:R:F394	2.77	No	No	2	9	9
230	R:R:L77	R:R:L81	2.77	No	No	0	6	6
231	R:R:L76	R:R:N47	2.75	No	Yes	0	8	9
232	R:R:A367	R:R:Y32	2.67	No	Yes	0	5	5
233	R:R:F390	R:R:V54	2.62	Yes	No	0	9	8
234	R:R:F345	R:R:T368	2.59	Yes	No	0	8	6
235	R:R:V87	R:R:Y36	2.52	Yes	Yes	0	6	7
236	R:R:V54	R:R:Y66	2.52	No	No	0	8	5
237	R:R:V150	R:R:Y66	2.52	Yes	No	0	7	5
238	R:R:V68	R:R:Y383	2.52	No	Yes	0	8	9
239	R:R:V87	R:R:Y88	2.52	Yes	No	0	6	6
240	R:R:F162	R:R:L169	2.44	No	No	0	6	7
241	R:R:G93	R:R:G94	2.11	No	No	0	4	5
242	R:R:G143	R:R:S146	1.86	No	No	0	3	8
243	R:R:G94	R:R:T92	1.82	No	No	0	5	5
244	R:R:G141	R:R:T142	1.82	No	No	0	4	6
245	R:R:A72	R:R:C51	1.81	No	No	0	9	7
246	L:L:?1	R:R:L89	1.8	Yes	No	0	0	5
247	R:R:P344	R:R:T368	1.75	No	No	0	9	6
248	R:R:C102	R:R:S99	1.72	No	No	0	4	7
249	R:R:A33	R:R:V91	1.7	No	No	0	7	5
250	R:R:A123	R:R:V157	1.7	No	Yes	0	7	7
251	R:R:I40	R:R:P84	1.69	No	No	0	7	9
252	R:R:A377	R:R:I43	1.62	No	No	0	6	8
253	R:R:S182	R:R:V180	1.62	No	No	0	4	4
254	R:R:C400	R:R:K396	1.62	No	No	0	9	6
255	R:R:D187	R:R:P186	1.61	No	No	0	4	4
256	R:R:V87	R:R:V91	1.6	Yes	No	0	6	5
257	R:R:S182	R:R:T175	1.6	No	No	0	4	4
258	R:R:T155	R:R:V159	1.59	No	No	0	4	5
259	R:R:A163	R:R:L160	1.58	No	No	0	5	5
260	R:R:A327	R:R:L215	1.58	No	No	0	8	8
261	R:R:I190	R:R:V194	1.54	No	No	0	6	5
262	R:R:C147	R:R:Q144	1.53	No	No	0	4	5
263	R:R:F170	R:R:G171	1.51	No	No	0	5	5
264	R:R:L364	R:R:S361	1.5	No	No	0	5	5
265	R:R:L206	R:R:V207	1.49	No	No	0	4	7
266	R:R:L371	R:R:V340	1.49	No	No	0	8	4
267	R:R:K326	R:R:M330	1.44	No	No	0	8	8
268	R:R:E363	R:R:S361	1.44	No	No	0	1	5
269	R:R:E363	R:R:S366	1.44	No	No	0	1	6
270	R:R:Q217	R:R:V213	1.43	No	No	0	5	5
271	R:R:Q356	R:R:T357	1.42	No	No	0	3	4
272	R:R:L395	R:R:L398	1.38	No	No	0	5	7
273	R:R:E389	R:R:I388	1.37	No	No	0	7	5
274	R:R:R210	R:R:V213	1.31	No	No	0	6	5
275	R:R:V213	R:R:Y212	1.26	No	No	0	5	6
276	R:R:H140	R:R:Q139	1.24	No	No	0	5	6
277	R:R:Q144	R:R:R148	1.17	No	No	0	5	5
278	R:R:R218	R:R:R222	1.07	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y32	6.6	4	0	5
2	R:R:Y36	7.0125	4	0	7
3	R:R:N47	8.075	4	0	9
4	R:R:N65	8.0475	4	2	9
5	R:R:L67	6.4325	4	4	7
6	R:R:D75	10.475	4	0	9
7	R:R:V87	2.515	4	0	6
8	R:R:W96	8.41333	6	3	9
9	R:R:D110	9.3375	4	1	8
10	R:R:V150	6.385	4	4	7
11	R:R:V157	4.985	4	0	7
12	R:R:W158	5.635	4	0	9
13	R:R:L168	6.72	5	6	7
14	R:R:N173	7.4425	4	6	5
15	R:R:F188	8.64	4	0	7
16	R:R:F197	12.676	5	1	9
17	R:R:F201	7.334	5	1	6
18	R:R:Y208	8.02	5	0	9
19	R:R:F338	6.762	5	1	9
20	R:R:W342	8.81167	6	0	8
21	R:R:F345	9.37833	6	1	8
22	R:R:F346	11.604	5	1	7
23	R:R:H349	11.0425	4	1	8
24	R:R:W370	7.142	5	0	8
25	R:R:Y373	9.86	5	1	8
26	R:R:Y383	6.41429	7	5	9
27	R:R:F390	9.73143	7	2	9
28	L:L:?1	10.2309	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W370	R:R:Y32	11.0117	7.72	Yes	Yes	0	8	5
2	R:R:V86	R:R:Y36	48.7012	8.83	No	Yes	0	8	7
3	R:R:W370	R:R:Y36	30.0586	7.72	Yes	Yes	0	8	7
4	R:R:V86	R:R:Y373	51.0663	7.57	No	Yes	0	8	8
5	R:R:D75	R:R:N379	39.6452	10.77	Yes	No	0	9	9
6	R:R:N375	R:R:N379	99.2015	12.26	No	No	0	9	9
7	R:R:N375	R:R:W342	100	13.56	No	Yes	0	9	8
8	R:R:C114	R:R:W342	69.9565	5.22	No	Yes	0	7	8
9	R:R:C114	R:R:D110	16.3483	4.67	No	Yes	1	7	8
10	R:R:D110	R:R:Y373	15.2365	9.2	Yes	Yes	1	8	8
11	L:L:?1	R:R:C114	53.5577	5.16	Yes	No	1	0	7
12	L:L:?1	R:R:Y373	45.0323	16.76	Yes	Yes	1	0	8
13	R:R:F346	R:R:W342	72.4581	6.01	Yes	Yes	0	7	8
14	L:L:?1	R:R:F346	76.7688	10.29	Yes	Yes	1	0	7
15	R:R:D75	R:R:N47	24.9293	13.46	Yes	Yes	0	9	9
16	R:R:G46	R:R:P380	11.5221	4.06	No	No	0	9	9
17	R:R:N47	R:R:P380	13.4678	11.4	Yes	No	0	9	9
18	R:R:F390	R:R:V54	24.9899	2.62	Yes	No	0	9	8
19	R:R:V54	R:R:Y66	28.4011	2.52	No	No	0	8	5
20	R:R:V150	R:R:Y66	33.4496	2.52	Yes	No	0	7	5
21	R:R:L67	R:R:V150	44.8302	8.94	Yes	Yes	4	7	7
22	R:R:I154	R:R:L67	77.7694	5.71	No	Yes	0	8	7
23	R:R:I154	R:R:S70	79.2349	10.84	No	No	0	8	9
24	R:R:N120	R:R:S70	83.0857	8.94	No	No	0	9	9
25	R:R:L71	R:R:N120	98.7518	5.49	No	No	0	9	9
26	R:R:L71	R:R:N379	83.682	12.36	No	No	0	9	9
27	R:R:E57	R:R:L60	10.8197	7.95	No	No	0	8	9
28	R:R:T64	R:R:Y138	16.3079	7.49	No	No	0	8	8
29	R:R:D127	R:R:Y138	19.7089	11.49	No	No	0	9	8
30	R:R:D127	R:R:L67	29.4522	5.43	No	Yes	0	9	7
31	R:R:T63	R:R:V150	11.3756	9.52	No	Yes	0	6	7
32	R:R:N120	R:R:V157	17.7633	8.87	No	Yes	0	9	7
33	R:R:F338	R:R:W342	48.1453	6.01	Yes	Yes	0	9	8
34	R:R:F338	R:R:L121	30.5337	6.09	Yes	No	0	9	8
35	R:R:L121	R:R:Y383	29.1844	7.03	No	Yes	0	8	9
36	R:R:F197	R:R:F346	29.0479	25.72	Yes	Yes	1	9	7
37	R:R:F197	R:R:F338	24.8484	5.36	Yes	Yes	1	9	9
38	R:R:L77	R:R:M113	10.5316	9.9	No	No	0	6	5
39	R:R:M112	R:R:M113	12.6087	7.22	No	No	0	7	5
40	R:R:F162	R:R:M112	16.7324	6.22	No	No	0	6	7
41	R:R:C166	R:R:F162	22.8421	9.78	No	No	0	6	6
42	R:R:C166	R:R:P167	24.8585	5.65	No	No	0	6	7
43	R:R:F188	R:R:P167	32.8229	4.33	Yes	No	0	7	7
44	R:R:F188	R:R:S192	36.5929	13.21	Yes	No	0	7	8
45	L:L:?1	R:R:S192	38.1999	6.83	Yes	No	0	0	8
46	R:R:C103	R:R:W96	16.4999	5.22	No	Yes	3	9	9
47	R:R:C103	R:R:R100	20.6236	5.57	No	No	0	9	3
48	R:R:R100	R:R:T175	28.6689	9.06	No	No	0	3	4
49	R:R:N173	R:R:T175	34.5967	5.85	Yes	No	0	5	4
50	R:R:L168	R:R:N173	38.4021	5.49	Yes	Yes	6	7	5
51	R:R:L168	R:R:V111	41.7829	4.47	Yes	No	0	7	8
52	L:L:?1	R:R:V111	43.5112	12.59	Yes	No	0	0	8
53	R:R:L119	R:R:V157	10.5822	4.47	No	Yes	0	7	7
54	R:R:F338	R:R:T204	45.381	7.78	Yes	No	0	9	8
55	R:R:R128	R:R:Y383	11.9214	6.17	No	Yes	5	9	9
56	R:R:S125	R:R:T204	34.8191	6.4	No	No	0	9	8
57	R:R:S125	R:R:V207	45.2598	8.08	No	No	0	9	7
58	R:R:S125	R:R:Y208	20.3861	8.9	No	Yes	0	9	9
59	R:R:V133	R:R:Y129	33.9802	16.4	No	No	0	7	9
60	R:R:V207	R:R:Y129	39.6402	3.79	No	No	0	7	9
61	R:R:H349	R:R:V189	12.1235	12.45	Yes	No	0	8	7
62	L:L:?1	R:R:H349	12.169	11.7	Yes	Yes	1	0	8
63	R:R:V334	R:R:Y383	12.1336	7.57	No	Yes	0	8	9
64	R:R:R210	R:R:V214	20.2598	7.85	No	No	0	6	7
65	R:R:V133	R:R:V214	22.827	3.21	No	No	7	7	7
66	R:R:V213	R:R:Y212	11.5423	1.26	No	No	0	5	6
67	R:R:R210	R:R:V213	17.3641	1.31	No	No	0	6	5
68	R:R:F386	R:R:I333	12.2397	5.02	No	No	0	7	8
69	R:R:I333	R:R:I382	17.0002	2.94	No	No	0	8	8
70	R:R:I382	R:R:Y383	21.7607	9.67	No	Yes	0	8	9
71	R:R:V87	R:R:Y36	14.1197	2.52	Yes	Yes	0	6	7
72	L:L:?1	R:R:L89	10.3598	1.8	Yes	No	0	0	5
73	R:R:F345	R:R:T368	13.5739	2.59	Yes	No	0	8	6
74	R:R:F345	R:R:F346	21.4322	10.72	Yes	Yes	1	8	7
75	R:R:L71	R:R:Y383	28.4415	4.69	No	Yes	0	9	9
76	R:R:R128	R:R:Y208	10.1425	10.29	No	Yes	0	9	9
77	R:R:V334	R:R:Y208	10.0768	8.83	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D110	R:R:V82	5.84	1	Yes	No	8	8	1	2
R:R:M83	R:R:Y373	10.78	0	No	Yes	8	8	2	1
R:R:V86	R:R:Y373	7.57	0	No	Yes	8	8	2	1
R:R:C114	R:R:D110	4.67	1	No	Yes	7	8	1	1
R:R:D110	R:R:Y373	9.2	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D110	17.64	1	Yes	Yes	0	8	0	1
R:R:L168	R:R:V111	4.47	6	Yes	No	7	8	2	1
L:L:?1	R:R:V111	12.59	1	Yes	No	0	8	0	1
R:R:C114	R:R:W342	5.22	1	No	Yes	7	8	1	2
L:L:?1	R:R:C114	5.16	1	Yes	No	0	7	0	1
R:R:S196	R:R:T115	9.59	0	No	No	8	8	1	2
R:R:S196	R:R:V164	4.85	0	No	No	8	7	1	2
R:R:F188	R:R:L168	13.4	0	Yes	Yes	7	7	2	2
R:R:F188	R:R:S192	13.21	0	Yes	No	7	8	2	1
R:R:H349	R:R:V189	12.45	1	Yes	No	8	7	1	2
L:L:?1	R:R:S192	6.83	1	Yes	No	0	8	0	1
R:R:F346	R:R:S193	5.28	1	Yes	No	7	8	1	2
R:R:F197	R:R:F346	25.72	1	Yes	Yes	9	7	2	1
R:R:F346	R:R:W342	6.01	1	Yes	Yes	7	8	1	2
R:R:F345	R:R:F346	10.72	1	Yes	Yes	8	7	1	1
R:R:F345	R:R:H349	11.31	1	Yes	Yes	8	8	1	1
R:R:F345	R:R:Y365	8.25	1	Yes	No	8	4	1	2
R:R:F345	R:R:T369	5.19	1	Yes	No	8	6	1	1
L:L:?1	R:R:F345	18.21	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F346	10.29	1	Yes	Yes	0	7	0	1
R:R:H349	R:R:Y365	8.71	1	Yes	No	8	4	1	2
L:L:?1	R:R:H349	11.7	1	Yes	Yes	0	8	0	1
R:R:T369	R:R:Y373	4.99	1	No	Yes	6	8	1	1
L:L:?1	R:R:T369	7.66	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y373	16.76	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S196	3.9	1	Yes	No	0	8	0	1
R:R:G94	R:R:L89	3.42	0	No	No	5	5	2	1
R:R:F345	R:R:T368	2.59	1	Yes	No	8	6	1	2
L:L:?1	R:R:L89	1.8	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IRT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.32
Number of Linked Nodes	253
Number of Links	278
Number of Hubs	28
Number of Links mediated by Hubs	116
Number of Communities	9
Number of Nodes involved in Communities	44
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	51719
Length Of Smallest Path	3
Average Path Length	13.2889
Length of Longest Path	29
Minimum Path Strength	1.285
Average Path Strength	7.81602
Maximum Path Strength	20.9
Minimum Path Correlation	0.7
Average Path Correlation	0.925351
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	51.2544
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.7179
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • electron transport chain • metabolic process • generation of precursor metabolites and energy • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of gliogenesis • regulation of cell development • regulation of nervous system development • neurogenesis • negative regulation of neurogenesis • gliogenesis • cell differentiation • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of nervous system development • negative regulation of cell differentiation • regulation of multicellular organismal development • negative regulation of developmental process • regulation of glial cell differentiation • nervous system development • negative regulation of gliogenesis • negative regulation of cell development • negative regulation of oligodendrocyte differentiation • negative regulation of glial cell differentiation • central nervous system development • oligodendrocyte differentiation • glial cell differentiation • negative regulation of multicellular organismal process • regulation of oligodendrocyte differentiation • response to xenobiotic stimulus • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • negative regulation of protein transport • protein localization • regulation of localization • establishment of protein localization • cellular localization • nitrogen compound transport • regulation of protein localization • negative regulation of transport • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • negative regulation of secretion • cellular macromolecule localization • negative regulation of secretion by cell • negative regulation of protein localization • regulation of transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • regulation of cellular localization • behavior • locomotory behavior • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • learning • learning or memory • cognition • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • dopamine transport • catecholamine transport • signal release • dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • import into cell • regulation of catecholamine uptake involved in synaptic transmission • catecholamine uptake • dopamine uptake involved in synaptic transmission • establishment of localization in cell • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • trans-synaptic signaling • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • chemical synaptic transmission • anterograde trans-synaptic signaling • neurotransmitter uptake • synaptic transmission, dopaminergic • dopamine uptake • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to light stimulus • visual learning • visual behavior • associative learning • response to radiation • response to abiotic stimulus • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of mitotic nuclear division • positive regulation of mitotic nuclear division • mitotic cell cycle • cellular component organization • regulation of mitotic cell cycle • cellular component organization or biogenesis • mitotic nuclear division • organelle fission • positive regulation of nuclear division • regulation of organelle organization • organelle organization • nuclear division • mitotic cell cycle process • regulation of nuclear division • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of metabolic process • response to histamine • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • biogenic amine metabolic process • startle response • regulation of response to external stimulus • neuromuscular process • negative regulation of response to stimulus • prepulse inhibition • response to external stimulus • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of signal transduction • negative regulation of cell communication • regulation of intracellular signal transduction • regulation of signaling • negative regulation of signal transduction • regulation of cell communication • phosphatidylinositol 3-kinase/protein kinase B signal transduction • multicellular organismal movement • musculoskeletal movement • reflex • musculoskeletal movement, spinal reflex action • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • regulation of trans-synaptic signaling • negative regulation of synaptic transmission, glutamatergic • response to morphine • response to isoquinoline alkaloid • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • biological process involved in intraspecies interaction between organisms • social behavior • positive regulation of cell communication • positive regulation of signal transduction • regulation of dopamine receptor signaling pathway • positive regulation of response to stimulus • regulation of G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of dopamine receptor signaling pathway • positive regulation of signaling • acid secretion • negative adaptation of signaling pathway • receptor internalization • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • vesicle-mediated transport • G protein-coupled receptor internalization • adaptation of signaling pathway • receptor-mediated endocytosis • endocytosis • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • phospholipase C-activating dopamine receptor signaling pathway • periplasmic space
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	R5F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	R5F
Name	Rotigotine
Synonyms	(6~{S})-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
Identifier
Formula	C19 H25 N O S
Molecular Weight	315.473
SMILES
PubChem	59227
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	1
Total Bonds	49
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35462
Sequence	>8IRT_nogp_Chain_R Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E R A L Q T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G G V W N F S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M P V H Y Q H G T G Q S S C R R V A L M I T A V W V L A F A V S C P L L F G F N T T G D P T V C S I S N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C Q T C H V S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F R K A F L K I L S C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9F34	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go1/β1/γ2	3.05	2024-09-18	10.1038/s41467-024-51993-4
	9F34 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	10.1038/s41467-024-51993-4
	9F33	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go1/β1/γ2	3.05	2024-09-18	10.1038/s41467-024-51993-4
	9F33 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	10.1038/s41467-024-51993-4
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/β1/γ2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol		3.15	2024-03-13	10.1101/2024.02.09.579708
	8JD3	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	HZR; PEF	Gi1/β1/γ2	3.3	2023-06-21	10.1038/s41422-023-00830-2
	8JD3 (No Gprot)	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	HZR; PEF		3.3	2023-06-21	10.1038/s41422-023-00830-2
	8IRT	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	2.7	2023-06-07	10.1038/s41422-023-00808-0
	8IRT (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-		2.7	2023-06-07	10.1038/s41422-023-00808-0
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	-	3.31	2025-02-26	To be published
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	10.1038/s41467-022-28417-2
	7LD3	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	PubChem 25263603	Gi2/β1/γ2	3.2	2021-09-08	10.1038/s41586-021-03897-2
	7LD3 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	PubChem 25263603		3.2	2021-09-08	10.1038/s41586-021-03897-2
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	10.1016/j.molcel.2021.01.003
	7CMU	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-	Gi1/β1/γ2	3	2021-03-10	10.1016/j.molcel.2021.01.003
	7CMU (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-		3	2021-03-10	10.1016/j.molcel.2021.01.003
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	10.1038/s41586-020-2994-1
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	3PBL	A	Amine	Dopamine	D₃	Homo sapiens	Eticlopride	-	-	2.89	2010-11-03	10.1126/science.1197410

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Download 8IRT_nogp.zip

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