psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H29	3.79	Yes	No	1	0	4
2	L:L:?1	R:R:E90	3.91	Yes	No	1	0	6
3	L:L:?1	R:R:G94	10.08	Yes	No	0	0	5
4	L:L:?1	R:R:F106	3.59	Yes	No	0	0	7
5	L:L:?1	R:R:D110	23.01	Yes	No	1	0	8
6	L:L:?1	R:R:V111	14.27	Yes	No	0	0	8
7	L:L:?1	R:R:C114	8.19	Yes	No	0	0	7
8	L:L:?1	R:R:S192	4.43	Yes	No	0	0	8
9	L:L:?1	R:R:F345	23.34	Yes	Yes	1	0	8
10	L:L:?1	R:R:F346	8.98	Yes	Yes	1	0	7
11	L:L:?1	R:R:T369	5.43	Yes	No	0	0	6
12	L:L:?1	R:R:Y373	4.32	Yes	Yes	1	0	8
13	R:R:E90	R:R:H29	9.85	No	No	1	6	4
14	R:R:E90	R:R:Y32	6.73	No	No	0	6	5
15	R:R:S366	R:R:Y32	5.09	No	No	0	6	5
16	R:R:S35	R:R:W370	8.65	No	Yes	0	4	8
17	R:R:M83	R:R:Y36	4.79	Yes	Yes	1	8	7
18	R:R:V86	R:R:Y36	3.79	No	Yes	1	8	7
19	R:R:T369	R:R:Y36	3.75	No	Yes	0	6	7
20	R:R:W370	R:R:Y36	12.54	Yes	Yes	1	8	7
21	R:R:Y36	R:R:Y373	4.96	Yes	Yes	1	7	8
22	R:R:L39	R:R:W370	10.25	No	Yes	1	7	8
23	R:R:L39	R:R:V374	4.47	No	No	1	7	5
24	R:R:I40	R:R:M83	5.83	No	Yes	0	7	8
25	R:R:I43	R:R:N47	4.25	No	Yes	0	8	9
26	R:R:A79	R:R:I43	4.87	No	No	0	8	8
27	R:R:F45	R:R:G46	4.52	No	No	0	5	9
28	R:R:A72	R:R:N47	4.69	No	Yes	0	9	9
29	R:R:D75	R:R:N47	4.04	Yes	Yes	0	9	9
30	R:R:L76	R:R:N47	8.24	No	Yes	0	8	9
31	R:R:N47	R:R:P380	6.52	Yes	No	0	9	9
32	R:R:F394	R:R:L49	8.53	Yes	No	0	9	7
33	R:R:T384	R:R:V50	6.35	Yes	No	0	8	9
34	R:R:I397	R:R:M52	4.37	Yes	No	0	7	5
35	R:R:L60	R:R:V54	4.47	Yes	No	0	9	8
36	R:R:V54	R:R:V69	4.81	No	No	0	8	7
37	R:R:A59	R:R:E57	4.53	No	Yes	0	6	8
38	R:R:E57	R:R:L60	13.25	Yes	Yes	0	8	9
39	R:R:E57	R:R:K392	8.1	Yes	No	0	8	6
40	R:R:Q61	R:R:R58	9.35	No	No	0	8	7
41	R:R:L60	R:R:N65	4.12	Yes	No	2	9	9
42	R:R:E389	R:R:L60	6.63	No	Yes	0	7	9
43	R:R:F390	R:R:L60	12.18	Yes	Yes	2	9	9
44	R:R:N65	R:R:T62	5.85	No	No	0	9	7
45	R:R:S146	R:R:T63	7.99	Yes	No	0	8	6
46	R:R:T63	R:R:V150	4.76	No	No	0	6	7
47	R:R:D127	R:R:T64	4.34	No	No	4	9	8
48	R:R:T64	R:R:Y138	3.75	No	Yes	4	8	8
49	R:R:F390	R:R:N65	7.25	Yes	No	2	9	9
50	R:R:I124	R:R:L67	4.28	No	No	0	9	7
51	R:R:D127	R:R:L67	5.43	No	No	0	9	7
52	R:R:N120	R:R:S70	7.45	No	No	0	9	9
53	R:R:I154	R:R:S70	6.19	No	No	0	8	9
54	R:R:S70	R:R:W158	4.94	No	No	0	9	9
55	R:R:D75	R:R:L71	4.07	Yes	No	1	9	9
56	R:R:L71	R:R:N120	5.49	No	No	0	9	9
57	R:R:L71	R:R:N379	6.87	No	Yes	1	9	9
58	R:R:D75	R:R:S117	4.42	Yes	No	0	9	9
59	R:R:D75	R:R:S376	8.83	Yes	No	0	9	9
60	R:R:D75	R:R:N379	4.04	Yes	Yes	1	9	9
61	R:R:L77	R:R:M113	5.65	No	No	0	6	5
62	R:R:S376	R:R:V78	6.46	No	No	0	9	8
63	R:R:L81	R:R:T80	4.42	No	No	0	6	5
64	R:R:D110	R:R:V82	5.84	No	No	0	8	8
65	R:R:M83	R:R:Y373	10.78	Yes	Yes	1	8	8
66	R:R:C102	R:R:W85	5.22	No	No	0	4	7
67	R:R:F106	R:R:W85	14.03	No	No	0	7	7
68	R:R:V86	R:R:Y373	3.79	No	Yes	1	8	8
69	R:R:T92	R:R:Y88	11.24	No	Yes	0	5	6
70	R:R:F98	R:R:Y88	9.28	No	Yes	0	6	6
71	R:R:L89	R:R:W96	4.56	No	Yes	0	5	9
72	R:R:T92	R:R:V95	4.76	No	No	0	5	3
73	R:R:F98	R:R:W96	4.01	No	Yes	3	6	9
74	R:R:C102	R:R:W96	7.84	No	Yes	3	4	9
75	R:R:C103	R:R:W96	6.53	Yes	Yes	3	9	9
76	R:R:C181	R:R:W96	9.14	No	Yes	3	9	9
77	R:R:C102	R:R:F98	5.59	No	No	3	4	6
78	R:R:I101	R:R:S99	4.64	No	No	0	4	7
79	R:R:C103	R:R:R100	8.36	Yes	No	0	9	3
80	R:R:R100	R:R:T175	10.35	No	No	0	3	4
81	R:R:C103	R:R:C181	7.28	Yes	No	3	9	9
82	R:R:D104	R:R:N173	8.08	No	No	0	6	5
83	R:R:L168	R:R:V107	4.47	No	No	0	7	7
84	R:R:I183	R:R:V107	4.61	No	No	0	7	7
85	R:R:S165	R:R:T108	4.8	No	No	0	8	7
86	R:R:L169	R:R:T108	7.37	No	No	0	7	7
87	R:R:D110	R:R:Y373	5.75	No	Yes	1	8	8
88	R:R:S165	R:R:V111	6.46	No	No	0	8	8
89	R:R:M112	R:R:M113	4.33	No	No	0	7	5
90	R:R:F162	R:R:M112	3.73	No	No	0	6	7
91	R:R:C114	R:R:W342	5.22	No	Yes	0	7	8
92	R:R:S196	R:R:T115	9.59	Yes	No	0	8	8
93	R:R:A116	R:R:W158	5.19	No	No	0	8	9
94	R:R:F338	R:R:I118	7.54	Yes	No	1	9	9
95	R:R:I118	R:R:W342	17.62	No	Yes	1	9	8
96	R:R:C122	R:R:W119	5.22	No	Yes	5	7	7
97	R:R:V157	R:R:W119	3.68	No	Yes	0	7	7
98	R:R:L160	R:R:W119	12.53	No	Yes	0	5	7
99	R:R:P200	R:R:W119	24.32	No	Yes	5	9	7
100	R:R:N120	R:R:V157	5.91	No	No	0	9	7
101	R:R:F338	R:R:L121	4.87	Yes	No	1	9	8
102	R:R:L121	R:R:N379	6.87	No	Yes	1	8	9
103	R:R:L121	R:R:Y383	7.03	No	Yes	1	8	9
104	R:R:C122	R:R:P200	3.77	No	No	5	7	9
105	R:R:I124	R:R:R128	5.01	No	No	1	9	9
106	R:R:I124	R:R:Y383	12.09	No	Yes	1	9	9
107	R:R:I126	R:R:S125	4.64	No	Yes	6	6	9
108	R:R:S125	R:R:T204	9.59	Yes	No	0	9	8
109	R:R:S125	R:R:V207	4.85	Yes	No	6	9	7
110	R:R:S125	R:R:Y208	5.09	Yes	Yes	0	9	9
111	R:R:I126	R:R:V207	4.61	No	No	6	6	7
112	R:R:D127	R:R:Y138	10.34	No	Yes	4	9	8
113	R:R:R128	R:R:Y208	8.23	No	Yes	0	9	9
114	R:R:R128	R:R:Y383	4.12	No	Yes	1	9	9
115	R:R:V133	R:R:Y129	8.83	No	Yes	0	7	9
116	R:R:V207	R:R:Y129	3.79	No	Yes	0	7	9
117	R:R:R210	R:R:Y129	8.23	No	Yes	0	6	9
118	R:R:I211	R:R:Y129	6.04	No	Yes	0	9	9
119	R:R:R149	R:R:T130	14.23	Yes	No	0	7	5
120	R:R:A131	R:R:Y138	9.34	No	Yes	0	8	8
121	R:R:H137	R:R:M134	7.88	No	No	0	5	6
122	R:R:G141	R:R:Y138	5.79	No	Yes	0	4	8
123	R:R:R149	R:R:Y138	4.12	Yes	Yes	0	7	8
124	R:R:H140	R:R:Q139	6.18	No	No	0	5	6
125	R:R:H140	R:R:T142	8.21	No	No	0	5	6
126	R:R:G141	R:R:S146	3.71	No	Yes	0	4	8
127	R:R:R149	R:R:S146	3.95	Yes	Yes	0	7	8
128	R:R:M153	R:R:R149	3.72	No	Yes	0	6	7
129	R:R:C166	R:R:F162	8.38	No	No	0	6	6
130	R:R:C166	R:R:P167	3.77	No	No	0	6	7
131	R:R:F188	R:R:P167	4.33	Yes	No	0	7	7
132	R:R:F188	R:R:L168	13.4	Yes	No	0	7	7
133	R:R:F172	R:R:N185	7.25	No	Yes	7	6	6
134	R:R:F172	R:R:F188	6.43	No	Yes	7	6	7
135	R:R:N185	R:R:T174	5.85	Yes	No	0	6	5
136	R:R:G176	R:R:T175	3.64	No	No	0	3	4
137	R:R:D177	R:R:P178	6.44	No	No	0	4	4
138	R:R:D177	R:R:T179	5.78	No	No	0	4	2
139	R:R:N185	R:R:P186	4.89	Yes	No	0	6	4
140	R:R:F188	R:R:N185	3.62	Yes	Yes	7	7	6
141	R:R:P186	R:R:T353	5.25	No	No	0	4	6
142	R:R:F188	R:R:S192	10.57	Yes	No	0	7	8
143	R:R:H349	R:R:V189	6.92	No	No	0	8	7
144	R:R:T353	R:R:V189	11.11	No	No	0	6	7
145	R:R:I190	R:R:Y191	3.63	No	No	0	6	6
146	R:R:F346	R:R:S193	5.28	Yes	No	0	7	8
147	R:R:F197	R:R:Y198	11.35	Yes	Yes	0	9	6
148	R:R:F197	R:R:F201	8.57	Yes	Yes	0	9	6
149	R:R:F197	R:R:W342	4.01	Yes	Yes	1	9	8
150	R:R:F197	R:R:L343	3.65	Yes	No	0	9	7
151	R:R:F197	R:R:F346	20.36	Yes	Yes	1	9	7
152	R:R:V350	R:R:Y198	3.79	No	Yes	0	6	6
153	R:R:F201	R:R:V205	3.93	Yes	No	0	6	5
154	R:R:F201	R:R:F338	9.65	Yes	Yes	0	6	9
155	R:R:F201	R:R:I339	7.54	Yes	No	0	6	5
156	R:R:L335	R:R:V205	7.45	No	No	0	8	5
157	R:R:V331	R:R:Y208	10.09	No	Yes	0	8	9
158	R:R:V334	R:R:Y208	6.31	No	Yes	0	8	9
159	R:R:R210	R:R:V214	7.85	No	No	0	6	7
160	R:R:K216	R:R:Y212	5.97	No	No	0	6	6
161	R:R:T328	R:R:Y212	3.75	No	No	0	8	6
162	R:R:K216	R:R:R220	4.95	No	No	0	6	6
163	R:R:K325	R:R:K326	10.06	No	Yes	0	7	8
164	R:R:K326	R:R:M330	8.64	Yes	Yes	8	8	8
165	R:R:F386	R:R:K326	3.72	No	Yes	8	7	8
166	R:R:M330	R:R:Q329	5.44	Yes	No	0	8	7
167	R:R:F386	R:R:M330	9.95	No	Yes	8	7	8
168	R:R:I333	R:R:I382	8.83	No	Yes	0	8	8
169	R:R:V334	R:R:Y383	5.05	No	Yes	0	8	9
170	R:R:F338	R:R:W342	7.02	Yes	Yes	1	9	8
171	R:R:I339	R:R:L343	5.71	No	No	0	5	7
172	R:R:C341	R:R:N375	9.45	No	No	0	8	9
173	R:R:F346	R:R:W342	4.01	Yes	Yes	1	7	8
174	R:R:G372	R:R:W342	5.63	No	Yes	0	7	8
175	R:R:N375	R:R:W342	10.17	No	Yes	0	9	8
176	R:R:F345	R:R:F346	12.86	Yes	Yes	1	8	7
177	R:R:F345	R:R:H349	6.79	Yes	No	0	8	8
178	R:R:F345	R:R:T368	5.19	Yes	No	0	8	6
179	R:R:L364	R:R:T348	4.42	No	No	0	5	6
180	R:R:T348	R:R:T368	6.28	No	No	0	6	6
181	R:R:H349	R:R:Y365	4.36	No	No	0	8	4
182	R:R:N352	R:R:V360	13.3	No	No	0	5	5
183	R:R:C355	R:R:Q356	4.58	No	No	0	5	3
184	R:R:C355	R:R:C358	7.28	No	No	0	5	4
185	R:R:E363	R:R:S361	11.5	No	No	0	1	5
186	R:R:V374	R:R:W370	7.36	No	Yes	1	5	8
187	R:R:N375	R:R:N379	8.17	No	Yes	0	9	9
188	R:R:I382	R:R:L378	4.28	Yes	No	0	8	7
189	R:R:N379	R:R:Y383	4.65	Yes	Yes	1	9	9
190	R:R:T385	R:R:V381	6.35	No	No	0	6	6
191	R:R:I382	R:R:Y383	3.63	Yes	Yes	0	8	9
192	R:R:F390	R:R:T384	9.08	Yes	Yes	2	9	8
193	R:R:F394	R:R:T384	5.19	Yes	Yes	2	9	8
194	R:R:E389	R:R:N387	13.15	No	No	0	7	9
195	R:R:F390	R:R:N387	10.87	Yes	No	0	9	9
196	R:R:I388	R:R:R391	3.76	No	No	0	5	9
197	R:R:F390	R:R:F394	8.57	Yes	Yes	2	9	9
198	R:R:I397	R:R:K396	5.82	Yes	No	0	7	6
199	R:R:N97	R:R:Y88	3.49	No	Yes	0	4	6
200	R:R:C37	R:R:V87	3.42	No	No	0	3	6
201	R:R:C122	R:R:V203	3.42	No	No	0	7	7
202	R:R:C341	R:R:V340	3.42	No	No	0	8	4
203	R:R:A72	R:R:V50	3.39	No	No	0	9	9
204	R:R:A161	R:R:T115	3.36	No	No	0	8	8
205	L:L:?1	R:R:S196	3.32	Yes	Yes	1	0	8
206	R:R:L199	R:R:P200	3.28	No	No	0	7	9
207	R:R:L343	R:R:P344	3.28	No	No	0	7	9
208	R:R:A377	R:R:I43	3.25	No	No	0	6	8
209	R:R:V132	R:R:V133	3.21	No	No	0	8	7
210	R:R:V164	R:R:V195	3.21	No	No	1	7	4
211	R:R:T179	R:R:V95	3.17	No	No	0	2	3
212	R:R:E363	R:R:P362	3.14	No	No	0	1	2
213	R:R:T384	R:R:T385	3.14	Yes	No	0	8	6
214	R:R:C103	R:R:D104	3.11	Yes	No	0	9	6
215	R:R:I190	R:R:V350	3.07	No	No	0	6	6
216	R:R:A393	R:R:E57	3.02	No	Yes	0	8	8
217	R:R:M134	R:R:T130	3.01	No	No	0	6	5
218	R:R:L76	R:R:V44	2.98	No	No	0	8	6
219	R:R:L77	R:R:V73	2.98	No	No	0	6	6
220	R:R:L109	R:R:V105	2.98	No	No	0	4	5
221	R:R:L215	R:R:V132	2.98	No	No	0	8	8
222	R:R:L77	R:R:T80	2.95	No	No	0	6	5
223	R:R:I333	R:R:M330	2.92	No	Yes	0	8	8
224	R:R:I397	R:R:K56	2.91	Yes	No	0	7	5
225	R:R:Q217	R:R:V213	2.87	No	No	0	5	5
226	R:R:I397	R:R:L49	2.85	Yes	No	0	7	7
227	R:R:I397	R:R:L398	2.85	Yes	No	0	7	7
228	R:R:E324	R:R:T328	2.82	No	No	0	8	8
229	R:R:D104	R:R:I101	2.8	No	No	0	6	4
230	R:R:H359	R:R:S361	2.79	No	No	0	2	5
231	R:R:A53	R:R:F394	2.77	No	Yes	0	9	9
232	R:R:L109	R:R:L81	2.77	No	No	0	4	6
233	R:R:R148	R:R:S145	2.64	No	No	0	5	7
234	R:R:R210	R:R:V213	2.62	No	No	0	6	5
235	R:R:A74	R:R:W158	2.59	No	No	0	8	9
236	R:R:L347	R:R:Y198	2.34	No	Yes	0	6	6
237	R:R:Q217	R:R:R220	2.34	No	No	0	5	6
238	R:R:E324	R:R:R219	2.33	No	No	0	8	5
239	R:R:G93	R:R:G94	2.11	No	No	0	4	5
240	R:R:G143	R:R:T142	1.82	No	No	0	3	6
241	R:R:A72	R:R:C51	1.81	No	No	0	9	7
242	R:R:G336	R:R:I339	1.76	No	No	0	6	5
243	R:R:C400	R:R:S399	1.72	No	No	0	9	4
244	R:R:G46	R:R:L49	1.71	No	No	0	9	7
245	R:R:C358	R:R:V360	1.71	No	No	0	4	5
246	R:R:A123	R:R:V157	1.7	No	No	0	7	7
247	R:R:G171	R:R:N173	1.7	No	No	0	5	5
248	R:R:C147	R:R:T63	1.69	No	No	0	4	6
249	R:R:M83	R:R:P84	1.68	Yes	No	0	8	9
250	R:R:M134	R:R:P135	1.68	No	No	0	6	8
251	R:R:L371	R:R:P344	1.64	No	No	0	8	9
252	R:R:S182	R:R:S184	1.63	No	No	0	4	5
253	R:R:S196	R:R:V164	1.62	Yes	No	1	8	7
254	R:R:S182	R:R:V180	1.62	No	No	0	4	4
255	R:R:S196	R:R:V195	1.62	Yes	No	1	8	4
256	R:R:A337	R:R:I382	1.62	No	Yes	0	6	8
257	R:R:D187	R:R:P186	1.61	No	No	0	4	4
258	R:R:V50	R:R:V68	1.6	No	No	0	9	8
259	R:R:T155	R:R:V159	1.59	No	No	0	4	5
260	R:R:T175	R:R:V180	1.59	No	No	0	4	4
261	R:R:A33	R:R:L34	1.58	No	No	0	7	6
262	R:R:A327	R:R:L215	1.58	No	No	0	8	8
263	R:R:I40	R:R:V87	1.54	No	No	0	7	6
264	R:R:F201	R:R:G202	1.51	Yes	No	0	6	4
265	R:R:L364	R:R:S361	1.5	No	No	0	5	5
266	R:R:L364	R:R:V360	1.49	No	No	0	5	5
267	R:R:Q139	R:R:S146	1.44	No	Yes	0	6	8
268	R:R:Q356	R:R:T357	1.42	No	No	0	3	4
269	R:R:I388	R:R:N387	1.42	No	No	0	5	9
270	R:R:H137	R:R:S145	1.39	No	No	0	5	7
271	R:R:H354	R:R:T353	1.37	No	No	0	4	6
272	R:R:V150	R:R:Y66	1.26	No	No	0	7	5
273	R:R:V91	R:R:Y88	1.26	No	Yes	0	5	6
274	R:R:V194	R:R:Y198	1.26	No	Yes	0	5	6
275	R:R:K221	R:R:R218	1.24	No	No	0	4	7
276	R:R:K326	R:R:R323	1.24	Yes	No	0	8	7
277	R:R:F170	R:R:L169	1.22	No	No	0	5	7
278	R:R:Q61	R:R:Y66	1.13	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.97385	13	1	0
2	R:R:Y36	5.966	5	1	7
3	R:R:N47	5.548	5	0	9
4	R:R:E57	7.225	4	0	8
5	R:R:L60	8.13	5	2	9
6	R:R:D75	5.08	5	1	9
7	R:R:M83	5.77	4	1	8
8	R:R:Y88	6.3175	4	0	6
9	R:R:W96	6.416	5	3	9
10	R:R:C103	6.32	4	3	9
11	R:R:W119	11.4375	4	5	7
12	R:R:S125	6.0425	4	6	9
13	R:R:Y129	6.7225	4	0	9
14	R:R:Y138	6.668	5	4	8
15	R:R:S146	4.2725	4	0	8
16	R:R:R149	6.505	4	0	7
17	R:R:N185	5.4025	4	7	6
18	R:R:F188	7.67	5	7	7
19	R:R:S196	4.0375	4	1	8
20	R:R:F197	9.588	5	1	9
21	R:R:Y198	4.685	4	0	6
22	R:R:F201	6.24	5	0	6
23	R:R:Y208	7.43	4	0	9
24	R:R:K326	5.915	4	8	8
25	R:R:M330	6.7375	4	8	8
26	R:R:F338	7.27	4	1	9
27	R:R:W342	7.66857	7	1	8
28	R:R:F345	12.045	4	1	8
29	R:R:F346	10.298	5	1	7
30	R:R:W370	9.7	4	1	8
31	R:R:Y373	5.92	5	1	8
32	R:R:N379	6.12	5	1	9
33	R:R:I382	4.59	4	0	8
34	R:R:Y383	6.095	6	1	9
35	R:R:T384	5.94	4	2	8
36	R:R:F390	9.59	5	2	9
37	R:R:F394	6.265	4	2	9
38	R:R:I397	3.76	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T369	11.3447	5.43	Yes	No	0	0	6
2	R:R:W370	R:R:Y36	15.6226	12.54	Yes	Yes	1	8	7
3	L:L:?1	R:R:Y373	22.7115	4.32	Yes	Yes	1	0	8
4	L:L:?1	R:R:C114	67.4641	8.19	Yes	No	0	0	7
5	R:R:C114	R:R:W342	68.0716	5.22	No	Yes	0	7	8
6	R:R:N375	R:R:W342	100	10.17	No	Yes	0	9	8
7	R:R:N375	R:R:N379	99.3578	8.17	No	Yes	0	9	9
8	R:R:D75	R:R:N379	41.9447	4.04	Yes	Yes	1	9	9
9	R:R:D75	R:R:N47	40.3236	4.04	Yes	Yes	0	9	9
10	L:L:?1	R:R:F346	72.4345	8.98	Yes	Yes	1	0	7
11	R:R:F346	R:R:W342	85.3091	4.01	Yes	Yes	1	7	8
12	R:R:A72	R:R:N47	33.6911	4.69	No	Yes	0	9	9
13	R:R:A72	R:R:V50	31.7395	3.39	No	No	0	9	9
14	R:R:T384	R:R:V50	29.7312	6.35	Yes	No	0	8	9
15	R:R:F394	R:R:T384	10.6554	5.19	Yes	Yes	2	9	8
16	R:R:F390	R:R:T384	16.1326	9.08	Yes	Yes	2	9	8
17	R:R:F338	R:R:W342	61.3573	7.02	Yes	Yes	1	9	8
18	R:R:F338	R:R:L121	68.3203	4.87	Yes	No	1	9	8
19	R:R:L121	R:R:Y383	66.3939	7.03	No	Yes	1	8	9
20	R:R:I124	R:R:Y383	58.858	12.09	No	Yes	1	9	9
21	R:R:I124	R:R:L67	60.0762	4.28	No	No	0	9	7
22	R:R:D127	R:R:L67	58.5023	5.43	No	No	0	9	7
23	R:R:D127	R:R:Y138	55.2537	10.34	No	Yes	4	9	8
24	R:R:G141	R:R:Y138	20.3066	5.79	No	Yes	0	4	8
25	R:R:G141	R:R:S146	18.6508	3.71	No	Yes	0	4	8
26	R:R:S146	R:R:T63	20.5364	7.99	Yes	No	0	8	6
27	R:R:T63	R:R:V150	13.7214	4.76	No	No	0	6	7
28	R:R:V150	R:R:Y66	10.2997	1.26	No	No	0	7	5
29	R:R:N379	R:R:Y383	78.0377	4.65	Yes	Yes	1	9	9
30	R:R:R149	R:R:Y138	31.9158	4.12	Yes	Yes	0	7	8
31	R:R:R149	R:R:S146	18.8838	3.95	Yes	Yes	0	7	8
32	R:R:L71	R:R:N379	14.8231	6.87	No	Yes	1	9	9
33	R:R:L71	R:R:N120	15.7737	5.49	No	No	0	9	9
34	L:L:?1	R:R:S192	39.8798	4.43	Yes	No	0	0	8
35	R:R:F188	R:R:S192	38.1768	10.57	Yes	No	0	7	8
36	R:R:F188	R:R:P167	21.6035	4.33	Yes	No	0	7	7
37	R:R:C166	R:R:P167	19.6707	3.77	No	No	0	6	7
38	R:R:C166	R:R:F162	17.7317	8.38	No	No	0	6	6
39	R:R:F162	R:R:M112	15.7863	3.73	No	No	0	6	7
40	R:R:M112	R:R:M113	13.8347	4.33	No	No	0	7	5
41	R:R:L77	R:R:M113	11.8767	5.65	No	No	0	6	5
42	L:L:?1	R:R:F106	51.1899	3.59	Yes	No	0	0	7
43	R:R:F106	R:R:W85	49.6002	14.03	No	No	0	7	7
44	R:R:C102	R:R:W85	47.7556	5.22	No	No	0	4	7
45	R:R:C102	R:R:F98	17.3036	5.59	No	No	3	4	6
46	R:R:F98	R:R:Y88	15.7832	9.28	No	Yes	0	6	6
47	R:R:C102	R:R:W96	28.6043	7.84	No	Yes	3	4	9
48	R:R:C103	R:R:W96	23.2498	6.53	Yes	Yes	3	9	9
49	R:R:C103	R:R:R100	11.8767	8.36	Yes	No	0	9	3
50	R:R:R128	R:R:Y383	35.5358	4.12	No	Yes	1	9	9
51	R:R:R128	R:R:Y208	36.7508	8.23	No	Yes	0	9	9
52	R:R:S125	R:R:Y208	65.2543	5.09	Yes	Yes	0	9	9
53	R:R:V334	R:R:Y383	36.0583	5.05	No	Yes	0	8	9
54	R:R:V334	R:R:Y208	34.4183	6.31	No	Yes	0	8	9
55	R:R:S125	R:R:V207	55.3985	4.85	Yes	No	6	9	7
56	R:R:V207	R:R:Y129	52.172	3.79	No	Yes	0	7	9
57	R:R:V133	R:R:Y129	12.6857	8.83	No	Yes	0	7	9
58	R:R:R210	R:R:Y129	33.134	8.23	No	Yes	0	6	9
59	R:R:R149	R:R:T130	10.4161	14.23	Yes	No	0	7	5
60	R:R:Q139	R:R:S146	13.7214	1.44	No	Yes	0	6	8
61	R:R:H140	R:R:Q139	10.2997	6.18	No	No	0	5	6
62	R:R:R210	R:R:V213	26.4858	2.62	No	No	0	6	5
63	R:R:Q217	R:R:V213	23.1491	2.87	No	No	0	5	5
64	R:R:Q217	R:R:R220	19.8061	2.34	No	No	0	5	6
65	R:R:K216	R:R:R220	16.4568	4.95	No	No	0	6	6
66	R:R:K216	R:R:Y212	13.1012	5.97	No	No	0	6	6
67	R:R:I382	R:R:Y383	18.0937	3.63	Yes	Yes	0	8	9
68	R:R:I333	R:R:I382	12.7078	8.83	No	Yes	0	8	8
69	R:R:I333	R:R:M330	11.0237	2.92	No	Yes	0	8	8
70	R:R:F345	R:R:T368	14.7444	5.19	Yes	No	0	8	6
71	R:R:T348	R:R:T368	13.6269	6.28	No	No	0	6	6
72	R:R:L364	R:R:T348	12.5	4.42	No	No	0	5	6
73	R:R:F345	R:R:F346	17.8922	12.86	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H29	3.79	1	Yes	No	0	4	0	1
L:L:?1	R:R:E90	3.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:G94	10.08	1	Yes	No	0	5	0	1
L:L:?1	R:R:F106	3.59	1	Yes	No	0	7	0	1
L:L:?1	R:R:D110	23.01	1	Yes	No	0	8	0	1
L:L:?1	R:R:V111	14.27	1	Yes	No	0	8	0	1
L:L:?1	R:R:C114	8.19	1	Yes	No	0	7	0	1
L:L:?1	R:R:S192	4.43	1	Yes	No	0	8	0	1
L:L:?1	R:R:F345	23.34	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F346	8.98	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T369	5.43	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y373	4.32	1	Yes	Yes	0	8	0	1
R:R:E90	R:R:H29	9.85	1	No	No	6	4	1	1
R:R:E90	R:R:Y32	6.73	1	No	No	6	5	1	2
R:R:M83	R:R:Y36	4.79	1	Yes	Yes	8	7	2	2
R:R:V86	R:R:Y36	3.79	1	No	Yes	8	7	2	2
R:R:T369	R:R:Y36	3.75	0	No	Yes	6	7	1	2
R:R:Y36	R:R:Y373	4.96	1	Yes	Yes	7	8	2	1
R:R:D110	R:R:V82	5.84	1	No	No	8	8	1	2
R:R:M83	R:R:Y373	10.78	1	Yes	Yes	8	8	2	1
R:R:F106	R:R:W85	14.03	0	No	No	7	7	1	2
R:R:V86	R:R:Y373	3.79	1	No	Yes	8	8	2	1
R:R:D110	R:R:Y373	5.75	1	No	Yes	8	8	1	1
R:R:S165	R:R:V111	6.46	0	No	No	8	8	2	1
R:R:C114	R:R:W342	5.22	0	No	Yes	7	8	1	2
R:R:S196	R:R:T115	9.59	1	Yes	No	8	8	1	2
R:R:F188	R:R:S192	10.57	7	Yes	No	7	8	2	1
R:R:F346	R:R:S193	5.28	1	Yes	No	7	8	1	2
R:R:F197	R:R:W342	4.01	1	Yes	Yes	9	8	2	2
R:R:F197	R:R:F346	20.36	1	Yes	Yes	9	7	2	1
R:R:F346	R:R:W342	4.01	1	Yes	Yes	7	8	1	2
R:R:F345	R:R:F346	12.86	1	Yes	Yes	8	7	1	1
R:R:F345	R:R:H349	6.79	1	Yes	No	8	8	1	2
R:R:F345	R:R:T368	5.19	1	Yes	No	8	6	1	2
L:L:?1	R:R:S196	3.32	1	Yes	Yes	0	8	0	1
R:R:V164	R:R:V195	3.21	1	No	No	7	4	2	2
R:R:G93	R:R:G94	2.11	0	No	No	4	5	2	1
R:R:S196	R:R:V164	1.62	1	Yes	No	8	7	1	2
R:R:S196	R:R:V195	1.62	1	Yes	No	8	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9F33_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	253
Number of Links	278
Number of Hubs	38
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	52
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	71875
Length Of Smallest Path	3
Average Path Length	14.6072
Length of Longest Path	32
Minimum Path Strength	1.195
Average Path Strength	6.41057
Maximum Path Strength	18.425
Minimum Path Correlation	0.7
Average Path Correlation	0.920773
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	40.0257
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8996
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • neurotransmitter receptor activity • dopamine neurotransmitter receptor activity • postsynaptic neurotransmitter receptor activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of gliogenesis • regulation of cell development • regulation of nervous system development • neurogenesis • negative regulation of neurogenesis • gliogenesis • cell differentiation • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of nervous system development • negative regulation of cell differentiation • regulation of multicellular organismal development • negative regulation of developmental process • regulation of glial cell differentiation • nervous system development • negative regulation of gliogenesis • negative regulation of cell development • negative regulation of oligodendrocyte differentiation • negative regulation of glial cell differentiation • central nervous system development • oligodendrocyte differentiation • glial cell differentiation • negative regulation of multicellular organismal process • regulation of oligodendrocyte differentiation • response to xenobiotic stimulus • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of transport • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • negative regulation of secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of protein localization • regulation of transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • behavior • locomotory behavior • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • learning • learning or memory • cognition • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • dopamine transport • catecholamine transport • signal release • cell-cell signaling • dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • import into cell • regulation of catecholamine uptake involved in synaptic transmission • cellular localization • catecholamine uptake • dopamine uptake involved in synaptic transmission • synaptic signaling • establishment of localization in cell • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • trans-synaptic signaling • catecholamine uptake involved in synaptic transmission • regulation of neurotransmitter transport • neurotransmitter transport • chemical synaptic transmission • anterograde trans-synaptic signaling • neurotransmitter uptake • synaptic transmission, dopaminergic • dopamine uptake • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to light stimulus • visual learning • visual behavior • associative learning • response to radiation • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of mitotic nuclear division • positive regulation of mitotic nuclear division • mitotic cell cycle • cellular component organization • regulation of mitotic cell cycle • cellular component organization or biogenesis • mitotic nuclear division • organelle fission • positive regulation of nuclear division • regulation of organelle organization • organelle organization • nuclear division • mitotic cell cycle process • regulation of nuclear division • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • response to histamine • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • biogenic amine metabolic process • startle response • regulation of response to external stimulus • neuromuscular process • negative regulation of response to stimulus • prepulse inhibition • response to external stimulus • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of signal transduction • intracellular signal transduction • negative regulation of cell communication • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • negative regulation of signal transduction • regulation of cell communication • phosphatidylinositol 3-kinase/protein kinase B signal transduction • multicellular organismal movement • musculoskeletal movement • reflex • musculoskeletal movement, spinal reflex action • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • regulation of trans-synaptic signaling • negative regulation of synaptic transmission, glutamatergic • response to morphine • response to isoquinoline alkaloid • negative regulation of cytosolic calcium ion concentration • biological process involved in intraspecies interaction between organisms • social behavior • positive regulation of cell communication • positive regulation of signal transduction • regulation of dopamine receptor signaling pathway • positive regulation of response to stimulus • regulation of G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of dopamine receptor signaling pathway • positive regulation of signaling • acid secretion • negative adaptation of signaling pathway • receptor internalization • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • vesicle-mediated transport • G protein-coupled receptor internalization • adaptation of signaling pathway • receptor-mediated endocytosis • endocytosis • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • phospholipase C-activating dopamine receptor signaling pathway • bioluminescence • generation of precursor metabolites and energy
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1H
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1H
Name	Molidustat
Synonyms	Molidustat Molidustat sodium
Identifier
Formula	C13 H14 N8 O2
Molecular Weight	314.303
SMILES
PubChem	59603622
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	0
Total Bonds	40
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35462
Sequence	>9F33_nogp_Chain_R H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E R A L Q T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G G V W N F S R I C C D V F V T L D V M M C T A S I N L C A I S I D R Y T A V V M P V H Y Q H G T G Q S S C R R V A L M I T A V W V L A F A V S C P L L F G F N T T G D P T V C S I S N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C Q T C H V S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F R K A F L K I L S C W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7LD3	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	MIPS521	Gi2/β1/γ2	3.2	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	7LD3 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	MIPS521		3.2	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	Gi1/β1/γ2	3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-		3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	-	3.31	2025-02-26	doi.org/10.1073/pnas.2425795122
	7CMU	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-	Gi1/β1/γ2	3	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMU (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-		3	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	8IRT	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	2.7	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRT (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-		2.7	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	9F33	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go/β1/γ2	3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	9F33 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	9F34	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go/β1/γ2	3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	9F34 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	3PBL	A	Amine	Dopamine	D₃	Homo sapiens	Eticlopride	-	-	2.89	2010-11-03	doi.org/10.1126/science.1197410
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8JD3	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	JNJ-40411813	Gi1/β1/γ2	3.3	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8JD3 (No Gprot)	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	JNJ-40411813		3.3	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1

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