psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H29	3.45	Yes	No	1	0	4
2	L:L:?1	R:R:E90	3.55	Yes	No	1	0	6
3	L:L:?1	R:R:G94	9.17	Yes	No	0	0	5
4	L:L:?1	R:R:D110	20.91	Yes	No	1	0	8
5	L:L:?1	R:R:V111	12.97	Yes	No	0	0	8
6	L:L:?1	R:R:C114	7.44	Yes	No	0	0	7
7	L:L:?1	R:R:S192	4.02	Yes	No	0	0	8
8	L:L:?1	R:R:F345	21.21	Yes	Yes	1	0	8
9	L:L:?1	R:R:F346	8.16	Yes	Yes	1	0	7
10	L:L:?1	R:R:T369	4.94	Yes	No	0	0	6
11	L:L:?1	R:R:Y373	3.93	Yes	Yes	1	0	8
12	R:R:E90	R:R:H29	9.85	No	No	1	6	4
13	R:R:E90	R:R:Y32	6.73	No	No	0	6	5
14	R:R:S366	R:R:Y32	5.09	No	No	0	6	5
15	R:R:S35	R:R:W370	8.65	No	Yes	0	4	8
16	R:R:M83	R:R:Y36	4.79	Yes	Yes	1	8	7
17	R:R:V86	R:R:Y36	3.79	No	Yes	1	8	7
18	R:R:T369	R:R:Y36	3.75	No	Yes	0	6	7
19	R:R:W370	R:R:Y36	12.54	Yes	Yes	1	8	7
20	R:R:Y36	R:R:Y373	4.96	Yes	Yes	1	7	8
21	R:R:C37	R:R:V87	3.42	No	No	0	3	6
22	R:R:L39	R:R:W370	10.25	No	Yes	1	7	8
23	R:R:L39	R:R:V374	4.47	No	No	1	7	5
24	R:R:I40	R:R:M83	5.83	No	Yes	0	7	8
25	R:R:I43	R:R:N47	4.25	No	Yes	0	8	9
26	R:R:A79	R:R:I43	4.87	No	No	0	8	8
27	R:R:F45	R:R:G46	4.52	No	No	0	5	9
28	R:R:A72	R:R:N47	4.69	No	Yes	0	9	9
29	R:R:D75	R:R:N47	4.04	Yes	Yes	0	9	9
30	R:R:L76	R:R:N47	8.24	No	Yes	0	8	9
31	R:R:N47	R:R:P380	6.52	Yes	No	0	9	9
32	R:R:F394	R:R:L49	8.53	Yes	No	0	9	7
33	R:R:A72	R:R:V50	3.39	No	No	0	9	9
34	R:R:T384	R:R:V50	6.35	Yes	No	0	8	9
35	R:R:I397	R:R:M52	4.37	Yes	No	0	7	5
36	R:R:L60	R:R:V54	4.47	Yes	No	0	9	8
37	R:R:V54	R:R:V69	4.81	No	No	0	8	7
38	R:R:A59	R:R:E57	4.53	No	Yes	0	6	8
39	R:R:E57	R:R:L60	13.25	Yes	Yes	0	8	9
40	R:R:E57	R:R:K392	8.1	Yes	No	0	8	6
41	R:R:Q61	R:R:R58	9.35	No	No	0	8	7
42	R:R:L60	R:R:N65	4.12	Yes	No	2	9	9
43	R:R:E389	R:R:L60	6.63	No	Yes	0	7	9
44	R:R:F390	R:R:L60	12.18	Yes	Yes	2	9	9
45	R:R:N65	R:R:T62	5.85	No	No	0	9	7
46	R:R:S146	R:R:T63	7.99	Yes	No	0	8	6
47	R:R:T63	R:R:V150	4.76	No	No	0	6	7
48	R:R:D127	R:R:T64	4.34	Yes	No	4	9	8
49	R:R:T64	R:R:Y138	3.75	No	Yes	4	8	8
50	R:R:F390	R:R:N65	7.25	Yes	No	2	9	9
51	R:R:I124	R:R:L67	4.28	No	No	0	9	7
52	R:R:D127	R:R:L67	5.43	Yes	No	0	9	7
53	R:R:N120	R:R:S70	7.45	No	No	0	9	9
54	R:R:I154	R:R:S70	6.19	No	No	0	8	9
55	R:R:S70	R:R:W158	4.94	No	No	0	9	9
56	R:R:D75	R:R:L71	4.07	Yes	No	1	9	9
57	R:R:L71	R:R:N120	5.49	No	No	0	9	9
58	R:R:L71	R:R:N379	6.87	No	Yes	1	9	9
59	R:R:D75	R:R:S117	4.42	Yes	No	0	9	9
60	R:R:D75	R:R:S376	8.83	Yes	No	0	9	9
61	R:R:D75	R:R:N379	4.04	Yes	Yes	1	9	9
62	R:R:L77	R:R:M113	5.65	No	No	0	6	5
63	R:R:S376	R:R:V78	6.46	No	No	0	9	8
64	R:R:L81	R:R:T80	4.42	No	No	0	6	5
65	R:R:D110	R:R:V82	5.84	No	No	0	8	8
66	R:R:M83	R:R:Y373	10.78	Yes	Yes	1	8	8
67	R:R:C102	R:R:W85	5.22	No	No	0	4	7
68	R:R:F106	R:R:W85	14.03	No	No	0	7	7
69	R:R:V86	R:R:Y373	3.79	No	Yes	1	8	8
70	R:R:T92	R:R:Y88	11.24	No	Yes	0	5	6
71	R:R:N97	R:R:Y88	3.49	No	Yes	0	4	6
72	R:R:F98	R:R:Y88	9.28	No	Yes	0	6	6
73	R:R:L89	R:R:W96	4.56	No	Yes	0	5	9
74	R:R:T92	R:R:V95	4.76	No	No	0	5	3
75	R:R:F98	R:R:W96	4.01	No	Yes	3	6	9
76	R:R:C102	R:R:W96	7.84	No	Yes	3	4	9
77	R:R:C103	R:R:W96	6.53	Yes	Yes	3	9	9
78	R:R:C181	R:R:W96	9.14	No	Yes	3	9	9
79	R:R:C102	R:R:F98	5.59	No	No	3	4	6
80	R:R:I101	R:R:S99	4.64	No	No	0	4	7
81	R:R:C103	R:R:R100	8.36	Yes	No	0	9	3
82	R:R:R100	R:R:T175	10.35	No	No	0	3	4
83	R:R:C103	R:R:C181	7.28	Yes	No	3	9	9
84	R:R:D104	R:R:N173	8.08	No	No	0	6	5
85	R:R:L168	R:R:V107	4.47	No	No	0	7	7
86	R:R:I183	R:R:V107	4.61	No	No	0	7	7
87	R:R:S165	R:R:T108	4.8	No	No	0	8	7
88	R:R:L169	R:R:T108	7.37	No	No	0	7	7
89	R:R:D110	R:R:Y373	5.75	No	Yes	1	8	8
90	R:R:S165	R:R:V111	6.46	No	No	0	8	8
91	R:R:M112	R:R:M113	4.33	No	No	0	7	5
92	R:R:F162	R:R:M112	3.73	No	No	0	6	7
93	R:R:C114	R:R:W342	5.22	No	Yes	0	7	8
94	R:R:S196	R:R:T115	9.59	Yes	No	0	8	8
95	R:R:A116	R:R:W158	5.19	No	No	0	8	9
96	R:R:I118	R:R:P200	3.39	No	Yes	1	9	9
97	R:R:F338	R:R:I118	7.54	Yes	No	1	9	9
98	R:R:I118	R:R:W342	17.62	No	Yes	1	9	8
99	R:R:C122	R:R:W119	5.22	Yes	Yes	1	7	7
100	R:R:V157	R:R:W119	3.68	No	Yes	0	7	7
101	R:R:L160	R:R:W119	12.53	No	Yes	0	5	7
102	R:R:P200	R:R:W119	24.32	Yes	Yes	1	9	7
103	R:R:N120	R:R:V157	5.91	No	No	0	9	7
104	R:R:F338	R:R:L121	4.87	Yes	No	1	9	8
105	R:R:L121	R:R:N379	6.87	No	Yes	1	8	9
106	R:R:L121	R:R:Y383	7.03	No	Yes	1	8	9
107	R:R:C122	R:R:S125	3.44	Yes	Yes	1	7	9
108	R:R:C122	R:R:P200	3.77	Yes	Yes	1	7	9
109	R:R:C122	R:R:V203	3.42	Yes	No	0	7	7
110	R:R:I124	R:R:R128	5.01	No	No	1	9	9
111	R:R:I124	R:R:Y383	12.09	No	Yes	1	9	9
112	R:R:I126	R:R:S125	4.64	No	Yes	1	6	9
113	R:R:S125	R:R:T204	9.59	Yes	No	0	9	8
114	R:R:S125	R:R:V207	4.85	Yes	No	1	9	7
115	R:R:S125	R:R:Y208	5.09	Yes	Yes	0	9	9
116	R:R:I126	R:R:V207	4.61	No	No	1	6	7
117	R:R:D127	R:R:Y138	10.34	Yes	Yes	4	9	8
118	R:R:D127	R:R:R149	3.57	Yes	Yes	4	9	7
119	R:R:R128	R:R:Y208	8.23	No	Yes	0	9	9
120	R:R:R128	R:R:Y383	4.12	No	Yes	1	9	9
121	R:R:V133	R:R:Y129	8.83	No	Yes	0	7	9
122	R:R:V207	R:R:Y129	3.79	No	Yes	0	7	9
123	R:R:R210	R:R:Y129	8.23	No	Yes	0	6	9
124	R:R:I211	R:R:Y129	6.04	No	Yes	0	9	9
125	R:R:R149	R:R:T130	14.23	Yes	No	0	7	5
126	R:R:A131	R:R:Y138	9.34	No	Yes	0	8	8
127	R:R:H137	R:R:M134	7.88	No	No	0	5	6
128	R:R:G141	R:R:Y138	5.79	No	Yes	0	4	8
129	R:R:R149	R:R:Y138	4.12	Yes	Yes	4	7	8
130	R:R:H140	R:R:Q139	6.18	No	No	0	5	6
131	R:R:H140	R:R:T142	8.21	No	No	0	5	6
132	R:R:G141	R:R:S146	3.71	No	Yes	0	4	8
133	R:R:R149	R:R:S146	3.95	Yes	Yes	0	7	8
134	R:R:M153	R:R:R149	3.72	No	Yes	0	6	7
135	R:R:C166	R:R:F162	8.38	No	No	0	6	6
136	R:R:C166	R:R:P167	3.77	No	No	0	6	7
137	R:R:F188	R:R:P167	4.33	Yes	No	0	7	7
138	R:R:F188	R:R:L168	13.4	Yes	No	0	7	7
139	R:R:F172	R:R:N185	7.25	No	Yes	5	6	6
140	R:R:F172	R:R:F188	6.43	No	Yes	5	6	7
141	R:R:N185	R:R:T174	5.85	Yes	No	0	6	5
142	R:R:G176	R:R:T175	3.64	No	No	0	3	4
143	R:R:D177	R:R:P178	6.44	No	No	0	4	4
144	R:R:D177	R:R:T179	5.78	No	No	0	4	2
145	R:R:N185	R:R:P186	4.89	Yes	No	0	6	4
146	R:R:F188	R:R:N185	3.62	Yes	Yes	5	7	6
147	R:R:P186	R:R:T353	5.25	No	No	0	4	6
148	R:R:F188	R:R:S192	10.57	Yes	No	0	7	8
149	R:R:H349	R:R:V189	6.92	No	No	0	8	7
150	R:R:T353	R:R:V189	11.11	No	No	0	6	7
151	R:R:I190	R:R:Y191	3.63	No	No	0	6	6
152	R:R:F346	R:R:S193	5.28	Yes	No	0	7	8
153	R:R:F197	R:R:Y198	11.35	Yes	Yes	0	9	6
154	R:R:F197	R:R:F201	8.57	Yes	Yes	0	9	6
155	R:R:F197	R:R:W342	4.01	Yes	Yes	1	9	8
156	R:R:F197	R:R:L343	3.65	Yes	No	0	9	7
157	R:R:F197	R:R:F346	20.36	Yes	Yes	1	9	7
158	R:R:V350	R:R:Y198	3.79	No	Yes	0	6	6
159	R:R:F201	R:R:V205	3.93	Yes	No	0	6	5
160	R:R:F201	R:R:F338	9.65	Yes	Yes	0	6	9
161	R:R:F201	R:R:I339	7.54	Yes	No	0	6	5
162	R:R:L335	R:R:V205	7.45	No	No	0	8	5
163	R:R:V331	R:R:Y208	10.09	No	Yes	0	8	9
164	R:R:V334	R:R:Y208	6.31	No	Yes	0	8	9
165	R:R:R210	R:R:V214	7.85	No	No	0	6	7
166	R:R:K216	R:R:Y212	5.97	No	No	0	6	6
167	R:R:T328	R:R:Y212	3.75	No	No	0	8	6
168	R:R:K216	R:R:R220	4.95	No	No	0	6	6
169	R:R:K325	R:R:K326	10.06	No	Yes	0	7	8
170	R:R:K326	R:R:M330	8.64	Yes	Yes	6	8	8
171	R:R:F386	R:R:K326	3.72	No	Yes	6	7	8
172	R:R:M330	R:R:Q329	5.44	Yes	No	0	8	7
173	R:R:F386	R:R:M330	9.95	No	Yes	6	7	8
174	R:R:I333	R:R:I382	8.83	No	Yes	0	8	8
175	R:R:V334	R:R:Y383	5.05	No	Yes	0	8	9
176	R:R:F338	R:R:W342	7.02	Yes	Yes	1	9	8
177	R:R:I339	R:R:L343	5.71	No	No	0	5	7
178	R:R:C341	R:R:V340	3.42	No	No	0	8	4
179	R:R:C341	R:R:N375	9.45	No	No	0	8	9
180	R:R:F346	R:R:W342	4.01	Yes	Yes	1	7	8
181	R:R:G372	R:R:W342	5.63	No	Yes	0	7	8
182	R:R:N375	R:R:W342	10.17	No	Yes	0	9	8
183	R:R:F345	R:R:F346	12.86	Yes	Yes	1	8	7
184	R:R:F345	R:R:H349	6.79	Yes	No	0	8	8
185	R:R:F345	R:R:T368	5.19	Yes	No	0	8	6
186	R:R:L364	R:R:T348	4.42	No	No	0	5	6
187	R:R:T348	R:R:T368	6.28	No	No	0	6	6
188	R:R:H349	R:R:Y365	4.36	No	No	0	8	4
189	R:R:N352	R:R:V360	13.3	No	No	0	5	5
190	R:R:C355	R:R:Q356	4.58	No	No	0	5	3
191	R:R:C355	R:R:C358	7.28	No	No	0	5	4
192	R:R:E363	R:R:S361	11.5	No	No	0	1	5
193	R:R:V374	R:R:W370	7.36	No	Yes	1	5	8
194	R:R:N375	R:R:N379	8.17	No	Yes	0	9	9
195	R:R:I382	R:R:L378	4.28	Yes	No	0	8	7
196	R:R:N379	R:R:Y383	4.65	Yes	Yes	1	9	9
197	R:R:T385	R:R:V381	6.35	No	No	0	6	6
198	R:R:I382	R:R:Y383	3.63	Yes	Yes	0	8	9
199	R:R:F390	R:R:T384	9.08	Yes	Yes	2	9	8
200	R:R:F394	R:R:T384	5.19	Yes	Yes	2	9	8
201	R:R:E389	R:R:N387	13.15	No	No	0	7	9
202	R:R:F390	R:R:N387	10.87	Yes	No	0	9	9
203	R:R:I388	R:R:R391	3.76	No	No	0	5	9
204	R:R:F390	R:R:F394	8.57	Yes	Yes	2	9	9
205	R:R:I397	R:R:K396	5.82	Yes	No	0	7	6
206	R:R:A161	R:R:T115	3.36	No	No	0	8	8
207	R:R:L199	R:R:P200	3.28	No	Yes	0	7	9
208	R:R:L343	R:R:P344	3.28	No	No	0	7	9
209	L:L:?1	R:R:F106	3.26	Yes	No	0	0	7
210	R:R:A377	R:R:I43	3.25	No	No	0	6	8
211	R:R:V132	R:R:V133	3.21	No	No	0	8	7
212	R:R:V164	R:R:V195	3.21	No	No	1	7	4
213	R:R:T179	R:R:V95	3.17	No	No	0	2	3
214	R:R:E363	R:R:P362	3.14	No	No	0	1	2
215	R:R:T384	R:R:T385	3.14	Yes	No	0	8	6
216	R:R:C103	R:R:D104	3.11	Yes	No	0	9	6
217	R:R:I190	R:R:V350	3.07	No	No	0	6	6
218	L:L:?1	R:R:S196	3.02	Yes	Yes	1	0	8
219	R:R:A393	R:R:E57	3.02	No	Yes	0	8	8
220	R:R:M134	R:R:T130	3.01	No	No	0	6	5
221	R:R:L76	R:R:V44	2.98	No	No	0	8	6
222	R:R:L77	R:R:V73	2.98	No	No	0	6	6
223	R:R:L109	R:R:V105	2.98	No	No	0	4	5
224	R:R:L215	R:R:V132	2.98	No	No	0	8	8
225	R:R:L77	R:R:T80	2.95	No	No	0	6	5
226	R:R:I333	R:R:M330	2.92	No	Yes	0	8	8
227	R:R:I397	R:R:K56	2.91	Yes	No	0	7	5
228	R:R:Q217	R:R:V213	2.87	No	No	0	5	5
229	R:R:I397	R:R:L49	2.85	Yes	No	0	7	7
230	R:R:I397	R:R:L398	2.85	Yes	No	0	7	7
231	R:R:E324	R:R:T328	2.82	No	No	0	8	8
232	R:R:D104	R:R:I101	2.8	No	No	0	6	4
233	R:R:H359	R:R:S361	2.79	No	No	0	2	5
234	R:R:A53	R:R:F394	2.77	No	Yes	0	9	9
235	R:R:L109	R:R:L81	2.77	No	No	0	4	6
236	R:R:R148	R:R:S145	2.64	No	No	0	5	7
237	R:R:R210	R:R:V213	2.62	No	No	0	6	5
238	R:R:A74	R:R:W158	2.59	No	No	0	8	9
239	R:R:L347	R:R:Y198	2.34	No	Yes	0	6	6
240	R:R:Q217	R:R:R220	2.34	No	No	0	5	6
241	R:R:E324	R:R:R219	2.33	No	No	0	8	5
242	R:R:G93	R:R:G94	2.11	No	No	0	4	5
243	R:R:G143	R:R:T142	1.82	No	No	0	3	6
244	R:R:A72	R:R:C51	1.81	No	No	0	9	7
245	R:R:G336	R:R:I339	1.76	No	No	0	6	5
246	R:R:C400	R:R:S399	1.72	No	No	0	9	4
247	R:R:G46	R:R:L49	1.71	No	No	0	9	7
248	R:R:C358	R:R:V360	1.71	No	No	0	4	5
249	R:R:A123	R:R:V157	1.7	No	No	0	7	7
250	R:R:G171	R:R:N173	1.7	No	No	0	5	5
251	R:R:C147	R:R:T63	1.69	No	No	0	4	6
252	R:R:M83	R:R:P84	1.68	Yes	No	0	8	9
253	R:R:M134	R:R:P135	1.68	No	No	0	6	8
254	R:R:L371	R:R:P344	1.64	No	No	0	8	9
255	R:R:S182	R:R:S184	1.63	No	No	0	4	5
256	R:R:S196	R:R:V164	1.62	Yes	No	1	8	7
257	R:R:S182	R:R:V180	1.62	No	No	0	4	4
258	R:R:S196	R:R:V195	1.62	Yes	No	1	8	4
259	R:R:A337	R:R:I382	1.62	No	Yes	0	6	8
260	R:R:D187	R:R:P186	1.61	No	No	0	4	4
261	R:R:V50	R:R:V68	1.6	No	No	0	9	8
262	R:R:T155	R:R:V159	1.59	No	No	0	4	5
263	R:R:T175	R:R:V180	1.59	No	No	0	4	4
264	R:R:A33	R:R:L34	1.58	No	No	0	7	6
265	R:R:A327	R:R:L215	1.58	No	No	0	8	8
266	R:R:I40	R:R:V87	1.54	No	No	0	7	6
267	R:R:F201	R:R:G202	1.51	Yes	No	0	6	4
268	R:R:L364	R:R:S361	1.5	No	No	0	5	5
269	R:R:L364	R:R:V360	1.49	No	No	0	5	5
270	R:R:Q139	R:R:S146	1.44	No	Yes	0	6	8
271	R:R:Q356	R:R:T357	1.42	No	No	0	3	4
272	R:R:I388	R:R:N387	1.42	No	No	0	5	9
273	R:R:H137	R:R:S145	1.39	No	No	0	5	7
274	R:R:H354	R:R:T353	1.37	No	No	0	4	6
275	R:R:V150	R:R:Y66	1.26	No	No	0	7	5
276	R:R:V91	R:R:Y88	1.26	No	Yes	0	5	6
277	R:R:V194	R:R:Y198	1.26	No	Yes	0	5	6
278	R:R:K221	R:R:R218	1.24	No	No	0	4	7
279	R:R:K326	R:R:R323	1.24	Yes	No	0	8	7
280	R:R:F170	R:R:L169	1.22	No	No	0	5	7
281	R:R:Q61	R:R:Y66	1.13	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.15615	13	1	0
2	R:R:Y36	5.966	5	1	7
3	R:R:N47	5.548	5	0	9
4	R:R:E57	7.225	4	0	8
5	R:R:L60	8.13	5	2	9
6	R:R:D75	5.08	5	1	9
7	R:R:M83	5.77	4	1	8
8	R:R:Y88	6.3175	4	0	6
9	R:R:W96	6.416	5	3	9
10	R:R:C103	6.32	4	3	9
11	R:R:W119	11.4375	4	1	7
12	R:R:C122	3.9625	4	1	7
13	R:R:S125	5.522	5	1	9
14	R:R:D127	5.92	4	4	9
15	R:R:Y129	6.7225	4	0	9
16	R:R:Y138	6.668	5	4	8
17	R:R:S146	4.2725	4	0	8
18	R:R:R149	5.918	5	4	7
19	R:R:N185	5.4025	4	5	6
20	R:R:F188	7.67	5	5	7
21	R:R:S196	3.9625	4	1	8
22	R:R:F197	9.588	5	1	9
23	R:R:Y198	4.685	4	0	6
24	R:R:P200	8.69	4	1	9
25	R:R:F201	6.24	5	0	6
26	R:R:Y208	7.43	4	0	9
27	R:R:K326	5.915	4	6	8
28	R:R:M330	6.7375	4	6	8
29	R:R:F338	7.27	4	1	9
30	R:R:W342	7.66857	7	1	8
31	R:R:F345	11.5125	4	1	8
32	R:R:F346	10.134	5	1	7
33	R:R:W370	9.7	4	1	8
34	R:R:Y373	5.842	5	1	8
35	R:R:N379	6.12	5	1	9
36	R:R:I382	4.59	4	0	8
37	R:R:Y383	6.095	6	1	9
38	R:R:T384	5.94	4	2	8
39	R:R:F390	9.59	5	2	9
40	R:R:F394	6.265	4	2	9
41	R:R:I397	3.76	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T369	13.3481	4.94	Yes	No	0	0	6
2	R:R:T369	R:R:Y36	11.1752	3.75	No	Yes	0	6	7
3	R:R:W370	R:R:Y36	18.4815	12.54	Yes	Yes	1	8	7
4	L:L:?1	R:R:Y373	26.7312	3.93	Yes	Yes	1	0	8
5	R:R:Y36	R:R:Y373	11.1953	4.96	Yes	Yes	1	7	8
6	R:R:M83	R:R:Y373	11.2154	10.78	Yes	Yes	1	8	8
7	L:L:?1	R:R:C114	73.8659	7.44	Yes	No	0	0	7
8	R:R:C114	R:R:W342	74.433	5.22	No	Yes	0	7	8
9	R:R:N375	R:R:W342	100	10.17	No	Yes	0	9	8
10	R:R:N375	R:R:N379	98.329	8.17	No	Yes	0	9	9
11	R:R:D75	R:R:N379	65.3553	4.04	Yes	Yes	1	9	9
12	R:R:D75	R:R:N47	62.9115	4.04	Yes	Yes	0	9	9
13	L:L:?1	R:R:F346	81.8497	8.16	Yes	Yes	1	0	7
14	R:R:F346	R:R:W342	93.2607	4.01	Yes	Yes	1	7	8
15	R:R:A72	R:R:N47	52.5843	4.69	No	Yes	0	9	9
16	R:R:A72	R:R:V50	49.5434	3.39	No	No	0	9	9
17	R:R:T384	R:R:V50	46.4121	6.35	Yes	No	0	8	9
18	R:R:F394	R:R:T384	16.6349	5.19	Yes	Yes	2	9	8
19	R:R:F394	R:R:L49	14.0807	8.53	Yes	No	0	9	7
20	R:R:F390	R:R:T384	25.1907	9.08	Yes	Yes	2	9	8
21	R:R:F390	R:R:L60	13.9502	12.18	Yes	Yes	2	9	9
22	R:R:F338	R:R:W342	45.8952	7.02	Yes	Yes	1	9	8
23	R:R:F338	R:R:L121	52.233	4.87	Yes	No	1	9	8
24	R:R:L121	R:R:Y383	48.9763	7.03	No	Yes	1	8	9
25	R:R:I124	R:R:Y383	65.265	12.09	No	Yes	1	9	9
26	R:R:I124	R:R:L67	66.655	4.28	No	No	0	9	7
27	R:R:D127	R:R:L67	64.0807	5.43	Yes	No	0	9	7
28	R:R:D127	R:R:R149	50.833	3.57	Yes	Yes	4	9	7
29	R:R:R149	R:R:S146	30.2589	3.95	Yes	Yes	0	7	8
30	R:R:S146	R:R:T63	16.7403	7.99	Yes	No	0	8	6
31	R:R:T63	R:R:V150	11.2154	4.76	No	No	0	6	7
32	R:R:N379	R:R:Y383	65.0492	4.65	Yes	Yes	1	9	9
33	R:R:L71	R:R:N120	11.6168	5.49	No	No	0	9	9
34	L:L:?1	R:R:S192	46.8336	4.02	Yes	No	0	0	8
35	R:R:F188	R:R:S192	44.8816	10.57	Yes	No	0	7	8
36	R:R:F188	R:R:P167	25.6072	4.33	Yes	No	0	7	7
37	R:R:C166	R:R:P167	23.329	3.77	No	No	0	6	7
38	R:R:C166	R:R:F162	21.0407	8.38	No	No	0	6	6
39	R:R:F162	R:R:M112	18.7425	3.73	No	No	0	6	7
40	R:R:M112	R:R:M113	16.4342	4.33	No	No	0	7	5
41	R:R:L77	R:R:M113	14.1158	5.65	No	No	0	6	5
42	L:L:?1	R:R:F106	60.0863	3.26	Yes	No	0	0	7
43	R:R:F106	R:R:W85	58.2748	14.03	No	No	0	7	7
44	R:R:C102	R:R:W85	56.1371	5.22	No	No	0	4	7
45	R:R:C102	R:R:F98	20.3583	5.59	No	No	3	4	6
46	R:R:F98	R:R:Y88	18.7375	9.28	No	Yes	0	6	6
47	R:R:T92	R:R:Y88	11.7874	11.24	No	Yes	0	5	6
48	R:R:C102	R:R:W96	33.6361	7.84	No	Yes	3	4	9
49	R:R:C103	R:R:W96	27.509	6.53	Yes	Yes	3	9	9
50	R:R:C103	R:R:D104	11.4813	3.11	Yes	No	0	9	6
51	R:R:C103	R:R:R100	14.1158	8.36	Yes	No	0	9	3
52	R:R:R100	R:R:T175	11.7874	10.35	No	No	0	3	4
53	L:L:?1	R:R:V111	11.6218	12.97	Yes	No	0	0	8
54	L:L:?1	R:R:S196	11.7122	3.02	Yes	Yes	1	0	8
55	R:R:I118	R:R:W342	32.6074	17.62	No	Yes	1	9	8
56	R:R:I118	R:R:P200	33.4605	3.39	No	Yes	1	9	9
57	R:R:C122	R:R:P200	26.0638	3.77	Yes	Yes	1	7	9
58	R:R:C122	R:R:S125	26.3047	3.44	Yes	Yes	1	7	9
59	R:R:S125	R:R:V207	32.1407	4.85	Yes	No	1	9	7
60	R:R:S125	R:R:Y208	18.2356	5.09	Yes	Yes	0	9	9
61	R:R:V207	R:R:Y129	30.3743	3.79	No	Yes	0	7	9
62	R:R:R210	R:R:Y129	19.445	8.23	No	Yes	0	6	9
63	R:R:R149	R:R:T130	16.6901	14.23	Yes	No	0	7	5
64	R:R:M134	R:R:T130	13.9452	3.01	No	No	0	6	5
65	R:R:Q139	R:R:S146	11.2154	1.44	No	Yes	0	6	8
66	R:R:F197	R:R:Y198	10.1265	11.35	Yes	Yes	0	9	6
67	R:R:V334	R:R:Y383	13.4886	5.05	No	Yes	0	8	9
68	R:R:V334	R:R:Y208	10.9996	6.31	No	Yes	0	8	9
69	R:R:R210	R:R:V213	15.6012	2.62	No	No	0	6	5
70	R:R:Q217	R:R:V213	13.6592	2.87	No	No	0	5	5
71	R:R:Q217	R:R:R220	11.7071	2.34	No	No	0	5	6
72	R:R:I382	R:R:Y383	28.6933	3.63	Yes	Yes	0	8	9
73	R:R:I333	R:R:I382	20.1525	8.83	No	Yes	0	8	8
74	R:R:I333	R:R:M330	17.4829	2.92	No	Yes	0	8	8
75	R:R:F345	R:R:T368	18.3661	5.19	Yes	No	0	8	6
76	R:R:T348	R:R:T368	16.9861	6.28	No	No	0	6	6
77	R:R:L364	R:R:T348	15.5911	4.42	No	No	0	5	6
78	R:R:R128	R:R:Y383	12.7108	4.12	No	Yes	1	9	9
79	R:R:R128	R:R:Y208	14.2864	8.23	No	Yes	0	9	9
80	R:R:F345	R:R:F346	20.2128	12.86	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H29	3.45	1	Yes	No	0	4	0	1
L:L:?1	R:R:E90	3.55	1	Yes	No	0	6	0	1
L:L:?1	R:R:G94	9.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:D110	20.91	1	Yes	No	0	8	0	1
L:L:?1	R:R:V111	12.97	1	Yes	No	0	8	0	1
L:L:?1	R:R:C114	7.44	1	Yes	No	0	7	0	1
L:L:?1	R:R:S192	4.02	1	Yes	No	0	8	0	1
L:L:?1	R:R:F345	21.21	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F346	8.16	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T369	4.94	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y373	3.93	1	Yes	Yes	0	8	0	1
R:R:E90	R:R:H29	9.85	1	No	No	6	4	1	1
R:R:E90	R:R:Y32	6.73	1	No	No	6	5	1	2
R:R:M83	R:R:Y36	4.79	1	Yes	Yes	8	7	2	2
R:R:V86	R:R:Y36	3.79	1	No	Yes	8	7	2	2
R:R:T369	R:R:Y36	3.75	0	No	Yes	6	7	1	2
R:R:Y36	R:R:Y373	4.96	1	Yes	Yes	7	8	2	1
R:R:D110	R:R:V82	5.84	1	No	No	8	8	1	2
R:R:M83	R:R:Y373	10.78	1	Yes	Yes	8	8	2	1
R:R:F106	R:R:W85	14.03	0	No	No	7	7	1	2
R:R:V86	R:R:Y373	3.79	1	No	Yes	8	8	2	1
R:R:D110	R:R:Y373	5.75	1	No	Yes	8	8	1	1
R:R:S165	R:R:V111	6.46	0	No	No	8	8	2	1
R:R:C114	R:R:W342	5.22	0	No	Yes	7	8	1	2
R:R:S196	R:R:T115	9.59	1	Yes	No	8	8	1	2
R:R:F188	R:R:S192	10.57	5	Yes	No	7	8	2	1
R:R:F346	R:R:S193	5.28	1	Yes	No	7	8	1	2
R:R:F197	R:R:W342	4.01	1	Yes	Yes	9	8	2	2
R:R:F197	R:R:F346	20.36	1	Yes	Yes	9	7	2	1
R:R:F346	R:R:W342	4.01	1	Yes	Yes	7	8	1	2
R:R:F345	R:R:F346	12.86	1	Yes	Yes	8	7	1	1
R:R:F345	R:R:H349	6.79	1	Yes	No	8	8	1	2
R:R:F345	R:R:T368	5.19	1	Yes	No	8	6	1	2
L:L:?1	R:R:F106	3.26	1	Yes	No	0	7	0	1
R:R:V164	R:R:V195	3.21	1	No	No	7	4	2	2
L:L:?1	R:R:S196	3.02	1	Yes	Yes	0	8	0	1
R:R:G93	R:R:G94	2.11	0	No	No	4	5	2	1
R:R:S196	R:R:V164	1.62	1	Yes	No	8	7	1	2
R:R:S196	R:R:V195	1.62	1	Yes	No	8	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9F33_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	253
Number of Links	281
Number of Hubs	41
Number of Links mediated by Hubs	157
Number of Communities	6
Number of Nodes involved in Communities	53
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	53712
Length Of Smallest Path	3
Average Path Length	13.0399
Length of Longest Path	30
Minimum Path Strength	1.195
Average Path Strength	6.42611
Maximum Path Strength	18.425
Minimum Path Correlation	0.7
Average Path Correlation	0.91983
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	43.5886
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.9551
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • regulation of cellular process • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of gliogenesis • regulation of cell development • regulation of nervous system development • multicellular organism development • neurogenesis • negative regulation of neurogenesis • gliogenesis • cell differentiation • anatomical structure development • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of nervous system development • negative regulation of cell differentiation • system development • developmental process • regulation of biological process • regulation of multicellular organismal development • negative regulation of developmental process • regulation of glial cell differentiation • biological regulation • nervous system development • negative regulation of gliogenesis • negative regulation of cell development • negative regulation of oligodendrocyte differentiation • negative regulation of glial cell differentiation • central nervous system development • oligodendrocyte differentiation • glial cell differentiation • cellular process • negative regulation of multicellular organismal process • regulation of oligodendrocyte differentiation • response to stimulus • response to chemical • response to xenobiotic stimulus • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • negative regulation of protein transport • regulation of localization • establishment of protein localization • regulation of protein localization • negative regulation of transport • protein localization to extracellular region • regulation of secretion by cell • secretion by cell • negative regulation of secretion • negative regulation of secretion by cell • intracellular protein localization • negative regulation of protein localization • regulation of transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • behavior • locomotory behavior • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • adult behavior • behavioral response to cocaine • response to oxygen-containing compound • response to nitrogen compound • response to cocaine • response to alkaloid • system process • learning • learning or memory • nervous system process • cognition • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • signaling • organic hydroxy compound transport • dopamine transport • cell communication • catecholamine transport • signal release • cell-cell signaling • dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • import into cell • cellular localization • catecholamine uptake • dopamine uptake involved in synaptic transmission • synaptic signaling • establishment of localization in cell • regulation of dopamine uptake involved in synaptic transmission • neurotransmitter reuptake • regulation of neurotransmitter uptake • trans-synaptic signaling • regulation of neurotransmitter transport • neurotransmitter transport • chemical synaptic transmission • anterograde trans-synaptic signaling • neurotransmitter uptake • synaptic transmission, dopaminergic • dopamine uptake • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • adenylate cyclase-inhibiting dopamine receptor signaling pathway • cellular response to stimulus • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • signal transduction • G protein-coupled dopamine receptor signaling pathway • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to light stimulus • visual learning • visual behavior • associative learning • response to radiation • response to abiotic stimulus • positive regulation of organelle organization • regulation of cellular component organization • positive regulation of cellular component organization • regulation of mitotic nuclear division • positive regulation of mitotic nuclear division • mitotic cell cycle • cellular component organization • regulation of mitotic cell cycle • cellular component organization or biogenesis • mitotic nuclear division • organelle fission • positive regulation of nuclear division • regulation of organelle organization • organelle organization • nuclear division • mitotic cell cycle process • regulation of nuclear division • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • response to histamine • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • biogenic amine metabolic process • startle response • regulation of response to external stimulus • neuromuscular process • negative regulation of response to stimulus • prepulse inhibition • response to external stimulus • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of potassium ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of signal transduction • intracellular signal transduction • negative regulation of cell communication • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • negative regulation of signal transduction • regulation of cell communication • phosphatidylinositol 3-kinase/protein kinase B signal transduction • multicellular organismal movement • musculoskeletal movement • reflex • musculoskeletal movement, spinal reflex action • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • regulation of trans-synaptic signaling • negative regulation of synaptic transmission, glutamatergic • response to morphine • response to isoquinoline alkaloid • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • biological process involved in intraspecies interaction between organisms • social behavior • positive regulation of cell communication • positive regulation of signal transduction • regulation of dopamine receptor signaling pathway • positive regulation of response to stimulus • regulation of G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • positive regulation of dopamine receptor signaling pathway • positive regulation of signaling • acid secretion • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative adaptation of signaling pathway • receptor internalization • desensitization of G protein-coupled receptor signaling pathway • negative regulation of G protein-coupled receptor signaling pathway • vesicle-mediated transport • G protein-coupled receptor internalization • adaptation of signaling pathway • receptor-mediated endocytosis • endocytosis • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • phospholipase C-activating dopamine receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • bioluminescence • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • cell body • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • regulation of blood circulation • heart contraction • membrane docking • organelle localization by membrane tethering • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of hormone secretion • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35462
Sequence	>9F33_nogp_Chain_R H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E R A L Q T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G G V W N F S R I C C D V F V T L D V M M C T A S I N L C A I S I D R Y T A V V M P V H Y Q H G T G Q S S C R R V A L M I T A V W V L A F A V S C P L L F G F N T T G D P T V C S I S N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C Q T C H V S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F R K A F L K I L S C W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3PBL	A	Amine	Dopamine	D₃	Homo sapiens	Eticlopride	-	-	2.89	2010-11-03	doi.org/10.1126/science.1197410
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	doi.org/10.1016/j.cell.2018.04.029
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7AD3	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2; STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	doi.org/10.1038/s41586-020-2994-1
	7CMU	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-	Gi1/β1/γ2	3	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMU (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-		3	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	doi.org/10.1016/j.molcel.2021.01.003
	7LD3	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	MIPS521	Gi2/β1/γ2	3.2	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	7LD3 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	MIPS521		3.2	2021-09-08	doi.org/10.1038/s41586-021-03897-2
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	doi.org/10.1038/s41467-022-28417-2
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	doi.org/10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	doi.org/10.1126/science.add6220
	8IRT	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	2.7	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8IRT (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-		2.7	2023-06-07	doi.org/10.1038/s41422-023-00808-0
	8JD3	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	JNJ-40411813	Gi1/β1/γ2	3.3	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	8JD3 (No Gprot)	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	JNJ-40411813		3.3	2023-06-21	doi.org/10.1038/s41422-023-00830-2
	9F33	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go/β1/γ2	3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	9F33 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	9F34	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go/β1/γ2	3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	9F34 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	doi.org/10.1038/s41467-024-51993-4
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	-	3.31	2025-02-26	doi.org/10.1073/pnas.2425795122
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-	Gi1/β1/γ2	3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	-		3.15	2024-03-13	doi.org/10.1101/2024.02.09.579708

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