psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H29	3.79	Yes	No	1	0	4
2	L:L:?1	R:R:E90	3.91	Yes	No	1	0	6
3	L:L:?1	R:R:G94	10.08	Yes	No	0	0	5
4	L:L:?1	R:R:F106	3.59	Yes	No	0	0	7
5	L:L:?1	R:R:D110	23.01	Yes	No	1	0	8
6	L:L:?1	R:R:V111	14.27	Yes	No	0	0	8
7	L:L:?1	R:R:C114	8.19	Yes	No	0	0	7
8	L:L:?1	R:R:S192	4.43	Yes	No	0	0	8
9	L:L:?1	R:R:F345	23.34	Yes	Yes	1	0	8
10	L:L:?1	R:R:F346	8.98	Yes	Yes	1	0	7
11	L:L:?1	R:R:T369	5.43	Yes	No	0	0	6
12	L:L:?1	R:R:Y373	4.32	Yes	Yes	1	0	8
13	R:R:E90	R:R:H29	9.85	No	No	1	6	4
14	R:R:E90	R:R:Y32	6.73	No	No	0	6	5
15	R:R:S366	R:R:Y32	5.09	No	No	0	6	5
16	R:R:S35	R:R:W370	8.65	No	Yes	0	4	8
17	R:R:M83	R:R:Y36	4.79	Yes	Yes	1	8	7
18	R:R:V86	R:R:Y36	3.79	No	Yes	1	8	7
19	R:R:T369	R:R:Y36	3.75	No	Yes	0	6	7
20	R:R:W370	R:R:Y36	12.54	Yes	Yes	1	8	7
21	R:R:Y36	R:R:Y373	4.96	Yes	Yes	1	7	8
22	R:R:L39	R:R:W370	10.25	No	Yes	1	7	8
23	R:R:L39	R:R:V374	4.47	No	No	1	7	5
24	R:R:I40	R:R:M83	5.83	No	Yes	0	7	8
25	R:R:I43	R:R:N47	4.25	No	Yes	0	8	9
26	R:R:A79	R:R:I43	4.87	No	No	0	8	8
27	R:R:F45	R:R:G46	4.52	No	No	0	5	9
28	R:R:A72	R:R:N47	4.69	No	Yes	0	9	9
29	R:R:D75	R:R:N47	4.04	Yes	Yes	0	9	9
30	R:R:L76	R:R:N47	8.24	No	Yes	0	8	9
31	R:R:N47	R:R:P380	6.52	Yes	No	0	9	9
32	R:R:F394	R:R:L49	8.53	Yes	No	0	9	7
33	R:R:T384	R:R:V50	6.35	Yes	No	0	8	9
34	R:R:I397	R:R:M52	4.37	Yes	No	0	7	5
35	R:R:L60	R:R:V54	4.47	Yes	No	0	9	8
36	R:R:V54	R:R:V69	4.81	No	No	0	8	7
37	R:R:A59	R:R:E57	4.53	No	Yes	0	6	8
38	R:R:E57	R:R:L60	13.25	Yes	Yes	0	8	9
39	R:R:E57	R:R:K392	8.1	Yes	No	0	8	6
40	R:R:Q61	R:R:R58	9.35	No	No	0	8	7
41	R:R:L60	R:R:N65	4.12	Yes	No	2	9	9
42	R:R:E389	R:R:L60	6.63	No	Yes	0	7	9
43	R:R:F390	R:R:L60	12.18	Yes	Yes	2	9	9
44	R:R:N65	R:R:T62	5.85	No	No	0	9	7
45	R:R:S146	R:R:T63	7.99	Yes	No	0	8	6
46	R:R:T63	R:R:V150	4.76	No	No	0	6	7
47	R:R:D127	R:R:T64	4.34	No	No	4	9	8
48	R:R:T64	R:R:Y138	3.75	No	Yes	4	8	8
49	R:R:F390	R:R:N65	7.25	Yes	No	2	9	9
50	R:R:I124	R:R:L67	4.28	No	No	0	9	7
51	R:R:D127	R:R:L67	5.43	No	No	0	9	7
52	R:R:N120	R:R:S70	7.45	No	No	0	9	9
53	R:R:I154	R:R:S70	6.19	No	No	0	8	9
54	R:R:S70	R:R:W158	4.94	No	No	0	9	9
55	R:R:D75	R:R:L71	4.07	Yes	No	1	9	9
56	R:R:L71	R:R:N120	5.49	No	No	0	9	9
57	R:R:L71	R:R:N379	6.87	No	Yes	1	9	9
58	R:R:D75	R:R:S117	4.42	Yes	No	0	9	9
59	R:R:D75	R:R:S376	8.83	Yes	No	0	9	9
60	R:R:D75	R:R:N379	4.04	Yes	Yes	1	9	9
61	R:R:L77	R:R:M113	5.65	No	No	0	6	5
62	R:R:S376	R:R:V78	6.46	No	No	0	9	8
63	R:R:L81	R:R:T80	4.42	No	No	0	6	5
64	R:R:D110	R:R:V82	5.84	No	No	0	8	8
65	R:R:M83	R:R:Y373	10.78	Yes	Yes	1	8	8
66	R:R:C102	R:R:W85	5.22	No	No	0	4	7
67	R:R:F106	R:R:W85	14.03	No	No	0	7	7
68	R:R:V86	R:R:Y373	3.79	No	Yes	1	8	8
69	R:R:T92	R:R:Y88	11.24	No	Yes	0	5	6
70	R:R:F98	R:R:Y88	9.28	No	Yes	0	6	6
71	R:R:L89	R:R:W96	4.56	No	Yes	0	5	9
72	R:R:T92	R:R:V95	4.76	No	No	0	5	3
73	R:R:F98	R:R:W96	4.01	No	Yes	3	6	9
74	R:R:C102	R:R:W96	7.84	No	Yes	3	4	9
75	R:R:C103	R:R:W96	6.53	Yes	Yes	3	9	9
76	R:R:C181	R:R:W96	9.14	No	Yes	3	9	9
77	R:R:C102	R:R:F98	5.59	No	No	3	4	6
78	R:R:I101	R:R:S99	4.64	No	No	0	4	7
79	R:R:C103	R:R:R100	8.36	Yes	No	0	9	3
80	R:R:R100	R:R:T175	10.35	No	No	0	3	4
81	R:R:C103	R:R:C181	7.28	Yes	No	3	9	9
82	R:R:D104	R:R:N173	8.08	No	No	0	6	5
83	R:R:L168	R:R:V107	4.47	No	No	0	7	7
84	R:R:I183	R:R:V107	4.61	No	No	0	7	7
85	R:R:S165	R:R:T108	4.8	No	No	0	8	7
86	R:R:L169	R:R:T108	7.37	No	No	0	7	7
87	R:R:D110	R:R:Y373	5.75	No	Yes	1	8	8
88	R:R:S165	R:R:V111	6.46	No	No	0	8	8
89	R:R:M112	R:R:M113	4.33	No	No	0	7	5
90	R:R:F162	R:R:M112	3.73	No	No	0	6	7
91	R:R:C114	R:R:W342	5.22	No	Yes	0	7	8
92	R:R:S196	R:R:T115	9.59	Yes	No	0	8	8
93	R:R:A116	R:R:W158	5.19	No	No	0	8	9
94	R:R:F338	R:R:I118	7.54	Yes	No	1	9	9
95	R:R:I118	R:R:W342	17.62	No	Yes	1	9	8
96	R:R:C122	R:R:W119	5.22	No	Yes	5	7	7
97	R:R:V157	R:R:W119	3.68	No	Yes	0	7	7
98	R:R:L160	R:R:W119	12.53	No	Yes	0	5	7
99	R:R:P200	R:R:W119	24.32	No	Yes	5	9	7
100	R:R:N120	R:R:V157	5.91	No	No	0	9	7
101	R:R:F338	R:R:L121	4.87	Yes	No	1	9	8
102	R:R:L121	R:R:N379	6.87	No	Yes	1	8	9
103	R:R:L121	R:R:Y383	7.03	No	Yes	1	8	9
104	R:R:C122	R:R:P200	3.77	No	No	5	7	9
105	R:R:I124	R:R:R128	5.01	No	No	1	9	9
106	R:R:I124	R:R:Y383	12.09	No	Yes	1	9	9
107	R:R:I126	R:R:S125	4.64	No	Yes	6	6	9
108	R:R:S125	R:R:T204	9.59	Yes	No	0	9	8
109	R:R:S125	R:R:V207	4.85	Yes	No	6	9	7
110	R:R:S125	R:R:Y208	5.09	Yes	Yes	0	9	9
111	R:R:I126	R:R:V207	4.61	No	No	6	6	7
112	R:R:D127	R:R:Y138	10.34	No	Yes	4	9	8
113	R:R:R128	R:R:Y208	8.23	No	Yes	0	9	9
114	R:R:R128	R:R:Y383	4.12	No	Yes	1	9	9
115	R:R:V133	R:R:Y129	8.83	No	Yes	0	7	9
116	R:R:V207	R:R:Y129	3.79	No	Yes	0	7	9
117	R:R:R210	R:R:Y129	8.23	No	Yes	0	6	9
118	R:R:I211	R:R:Y129	6.04	No	Yes	0	9	9
119	R:R:R149	R:R:T130	14.23	Yes	No	0	7	5
120	R:R:A131	R:R:Y138	9.34	No	Yes	0	8	8
121	R:R:H137	R:R:M134	7.88	No	No	0	5	6
122	R:R:G141	R:R:Y138	5.79	No	Yes	0	4	8
123	R:R:R149	R:R:Y138	4.12	Yes	Yes	0	7	8
124	R:R:H140	R:R:Q139	6.18	No	No	0	5	6
125	R:R:H140	R:R:T142	8.21	No	No	0	5	6
126	R:R:G141	R:R:S146	3.71	No	Yes	0	4	8
127	R:R:R149	R:R:S146	3.95	Yes	Yes	0	7	8
128	R:R:M153	R:R:R149	3.72	No	Yes	0	6	7
129	R:R:C166	R:R:F162	8.38	No	No	0	6	6
130	R:R:C166	R:R:P167	3.77	No	No	0	6	7
131	R:R:F188	R:R:P167	4.33	Yes	No	0	7	7
132	R:R:F188	R:R:L168	13.4	Yes	No	0	7	7
133	R:R:F172	R:R:N185	7.25	No	Yes	7	6	6
134	R:R:F172	R:R:F188	6.43	No	Yes	7	6	7
135	R:R:N185	R:R:T174	5.85	Yes	No	0	6	5
136	R:R:G176	R:R:T175	3.64	No	No	0	3	4
137	R:R:D177	R:R:P178	6.44	No	No	0	4	4
138	R:R:D177	R:R:T179	5.78	No	No	0	4	2
139	R:R:N185	R:R:P186	4.89	Yes	No	0	6	4
140	R:R:F188	R:R:N185	3.62	Yes	Yes	7	7	6
141	R:R:P186	R:R:T353	5.25	No	No	0	4	6
142	R:R:F188	R:R:S192	10.57	Yes	No	0	7	8
143	R:R:H349	R:R:V189	6.92	No	No	0	8	7
144	R:R:T353	R:R:V189	11.11	No	No	0	6	7
145	R:R:I190	R:R:Y191	3.63	No	No	0	6	6
146	R:R:F346	R:R:S193	5.28	Yes	No	0	7	8
147	R:R:F197	R:R:Y198	11.35	Yes	Yes	0	9	6
148	R:R:F197	R:R:F201	8.57	Yes	Yes	0	9	6
149	R:R:F197	R:R:W342	4.01	Yes	Yes	1	9	8
150	R:R:F197	R:R:L343	3.65	Yes	No	0	9	7
151	R:R:F197	R:R:F346	20.36	Yes	Yes	1	9	7
152	R:R:V350	R:R:Y198	3.79	No	Yes	0	6	6
153	R:R:F201	R:R:V205	3.93	Yes	No	0	6	5
154	R:R:F201	R:R:F338	9.65	Yes	Yes	0	6	9
155	R:R:F201	R:R:I339	7.54	Yes	No	0	6	5
156	R:R:L335	R:R:V205	7.45	No	No	0	8	5
157	R:R:V331	R:R:Y208	10.09	No	Yes	0	8	9
158	R:R:V334	R:R:Y208	6.31	No	Yes	0	8	9
159	R:R:R210	R:R:V214	7.85	No	No	0	6	7
160	R:R:K216	R:R:Y212	5.97	No	No	0	6	6
161	R:R:T328	R:R:Y212	3.75	No	No	0	8	6
162	R:R:K216	R:R:R220	4.95	No	No	0	6	6
163	R:R:K325	R:R:K326	10.06	No	Yes	0	7	8
164	R:R:K326	R:R:M330	8.64	Yes	Yes	8	8	8
165	R:R:F386	R:R:K326	3.72	No	Yes	8	7	8
166	R:R:M330	R:R:Q329	5.44	Yes	No	0	8	7
167	R:R:F386	R:R:M330	9.95	No	Yes	8	7	8
168	R:R:I333	R:R:I382	8.83	No	Yes	0	8	8
169	R:R:V334	R:R:Y383	5.05	No	Yes	0	8	9
170	R:R:F338	R:R:W342	7.02	Yes	Yes	1	9	8
171	R:R:I339	R:R:L343	5.71	No	No	0	5	7
172	R:R:C341	R:R:N375	9.45	No	No	0	8	9
173	R:R:F346	R:R:W342	4.01	Yes	Yes	1	7	8
174	R:R:G372	R:R:W342	5.63	No	Yes	0	7	8
175	R:R:N375	R:R:W342	10.17	No	Yes	0	9	8
176	R:R:F345	R:R:F346	12.86	Yes	Yes	1	8	7
177	R:R:F345	R:R:H349	6.79	Yes	No	0	8	8
178	R:R:F345	R:R:T368	5.19	Yes	No	0	8	6
179	R:R:L364	R:R:T348	4.42	No	No	0	5	6
180	R:R:T348	R:R:T368	6.28	No	No	0	6	6
181	R:R:H349	R:R:Y365	4.36	No	No	0	8	4
182	R:R:N352	R:R:V360	13.3	No	No	0	5	5
183	R:R:C355	R:R:Q356	4.58	No	No	0	5	3
184	R:R:C355	R:R:C358	7.28	No	No	0	5	4
185	R:R:E363	R:R:S361	11.5	No	No	0	1	5
186	R:R:V374	R:R:W370	7.36	No	Yes	1	5	8
187	R:R:N375	R:R:N379	8.17	No	Yes	0	9	9
188	R:R:I382	R:R:L378	4.28	Yes	No	0	8	7
189	R:R:N379	R:R:Y383	4.65	Yes	Yes	1	9	9
190	R:R:T385	R:R:V381	6.35	No	No	0	6	6
191	R:R:I382	R:R:Y383	3.63	Yes	Yes	0	8	9
192	R:R:F390	R:R:T384	9.08	Yes	Yes	2	9	8
193	R:R:F394	R:R:T384	5.19	Yes	Yes	2	9	8
194	R:R:E389	R:R:N387	13.15	No	No	0	7	9
195	R:R:F390	R:R:N387	10.87	Yes	No	0	9	9
196	R:R:I388	R:R:R391	3.76	No	No	0	5	9
197	R:R:F390	R:R:F394	8.57	Yes	Yes	2	9	9
198	R:R:I397	R:R:K396	5.82	Yes	No	0	7	6
199	R:R:N97	R:R:Y88	3.49	No	Yes	0	4	6
200	R:R:C37	R:R:V87	3.42	No	No	0	3	6
201	R:R:C122	R:R:V203	3.42	No	No	0	7	7
202	R:R:C341	R:R:V340	3.42	No	No	0	8	4
203	R:R:A72	R:R:V50	3.39	No	No	0	9	9
204	R:R:A161	R:R:T115	3.36	No	No	0	8	8
205	L:L:?1	R:R:S196	3.32	Yes	Yes	1	0	8
206	R:R:L199	R:R:P200	3.28	No	No	0	7	9
207	R:R:L343	R:R:P344	3.28	No	No	0	7	9
208	R:R:A377	R:R:I43	3.25	No	No	0	6	8
209	R:R:V132	R:R:V133	3.21	No	No	0	8	7
210	R:R:V164	R:R:V195	3.21	No	No	1	7	4
211	R:R:T179	R:R:V95	3.17	No	No	0	2	3
212	R:R:E363	R:R:P362	3.14	No	No	0	1	2
213	R:R:T384	R:R:T385	3.14	Yes	No	0	8	6
214	R:R:C103	R:R:D104	3.11	Yes	No	0	9	6
215	R:R:I190	R:R:V350	3.07	No	No	0	6	6
216	R:R:A393	R:R:E57	3.02	No	Yes	0	8	8
217	R:R:M134	R:R:T130	3.01	No	No	0	6	5
218	R:R:L76	R:R:V44	2.98	No	No	0	8	6
219	R:R:L77	R:R:V73	2.98	No	No	0	6	6
220	R:R:L109	R:R:V105	2.98	No	No	0	4	5
221	R:R:L215	R:R:V132	2.98	No	No	0	8	8
222	R:R:L77	R:R:T80	2.95	No	No	0	6	5
223	R:R:I333	R:R:M330	2.92	No	Yes	0	8	8
224	R:R:I397	R:R:K56	2.91	Yes	No	0	7	5
225	R:R:Q217	R:R:V213	2.87	No	No	0	5	5
226	R:R:I397	R:R:L49	2.85	Yes	No	0	7	7
227	R:R:I397	R:R:L398	2.85	Yes	No	0	7	7
228	R:R:E324	R:R:T328	2.82	No	No	0	8	8
229	R:R:D104	R:R:I101	2.8	No	No	0	6	4
230	R:R:H359	R:R:S361	2.79	No	No	0	2	5
231	R:R:A53	R:R:F394	2.77	No	Yes	0	9	9
232	R:R:L109	R:R:L81	2.77	No	No	0	4	6
233	R:R:R148	R:R:S145	2.64	No	No	0	5	7
234	R:R:R210	R:R:V213	2.62	No	No	0	6	5
235	R:R:A74	R:R:W158	2.59	No	No	0	8	9
236	R:R:L347	R:R:Y198	2.34	No	Yes	0	6	6
237	R:R:Q217	R:R:R220	2.34	No	No	0	5	6
238	R:R:E324	R:R:R219	2.33	No	No	0	8	5
239	R:R:G93	R:R:G94	2.11	No	No	0	4	5
240	R:R:G143	R:R:T142	1.82	No	No	0	3	6
241	R:R:A72	R:R:C51	1.81	No	No	0	9	7
242	R:R:G336	R:R:I339	1.76	No	No	0	6	5
243	R:R:C400	R:R:S399	1.72	No	No	0	9	4
244	R:R:G46	R:R:L49	1.71	No	No	0	9	7
245	R:R:C358	R:R:V360	1.71	No	No	0	4	5
246	R:R:A123	R:R:V157	1.7	No	No	0	7	7
247	R:R:G171	R:R:N173	1.7	No	No	0	5	5
248	R:R:C147	R:R:T63	1.69	No	No	0	4	6
249	R:R:M83	R:R:P84	1.68	Yes	No	0	8	9
250	R:R:M134	R:R:P135	1.68	No	No	0	6	8
251	R:R:L371	R:R:P344	1.64	No	No	0	8	9
252	R:R:S182	R:R:S184	1.63	No	No	0	4	5
253	R:R:S196	R:R:V164	1.62	Yes	No	1	8	7
254	R:R:S182	R:R:V180	1.62	No	No	0	4	4
255	R:R:S196	R:R:V195	1.62	Yes	No	1	8	4
256	R:R:A337	R:R:I382	1.62	No	Yes	0	6	8
257	R:R:D187	R:R:P186	1.61	No	No	0	4	4
258	R:R:V50	R:R:V68	1.6	No	No	0	9	8
259	R:R:T155	R:R:V159	1.59	No	No	0	4	5
260	R:R:T175	R:R:V180	1.59	No	No	0	4	4
261	R:R:A33	R:R:L34	1.58	No	No	0	7	6
262	R:R:A327	R:R:L215	1.58	No	No	0	8	8
263	R:R:I40	R:R:V87	1.54	No	No	0	7	6
264	R:R:F201	R:R:G202	1.51	Yes	No	0	6	4
265	R:R:L364	R:R:S361	1.5	No	No	0	5	5
266	R:R:L364	R:R:V360	1.49	No	No	0	5	5
267	R:R:Q139	R:R:S146	1.44	No	Yes	0	6	8
268	R:R:Q356	R:R:T357	1.42	No	No	0	3	4
269	R:R:I388	R:R:N387	1.42	No	No	0	5	9
270	R:R:H137	R:R:S145	1.39	No	No	0	5	7
271	R:R:H354	R:R:T353	1.37	No	No	0	4	6
272	R:R:V150	R:R:Y66	1.26	No	No	0	7	5
273	R:R:V91	R:R:Y88	1.26	No	Yes	0	5	6
274	R:R:V194	R:R:Y198	1.26	No	Yes	0	5	6
275	R:R:K221	R:R:R218	1.24	No	No	0	4	7
276	R:R:K326	R:R:R323	1.24	Yes	No	0	8	7
277	R:R:F170	R:R:L169	1.22	No	No	0	5	7
278	R:R:Q61	R:R:Y66	1.13	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.97385	13	1	0
2	R:R:Y36	5.966	5	1	7
3	R:R:N47	5.548	5	0	9
4	R:R:E57	7.225	4	0	8
5	R:R:L60	8.13	5	2	9
6	R:R:D75	5.08	5	1	9
7	R:R:M83	5.77	4	1	8
8	R:R:Y88	6.3175	4	0	6
9	R:R:W96	6.416	5	3	9
10	R:R:C103	6.32	4	3	9
11	R:R:W119	11.4375	4	5	7
12	R:R:S125	6.0425	4	6	9
13	R:R:Y129	6.7225	4	0	9
14	R:R:Y138	6.668	5	4	8
15	R:R:S146	4.2725	4	0	8
16	R:R:R149	6.505	4	0	7
17	R:R:N185	5.4025	4	7	6
18	R:R:F188	7.67	5	7	7
19	R:R:S196	4.0375	4	1	8
20	R:R:F197	9.588	5	1	9
21	R:R:Y198	4.685	4	0	6
22	R:R:F201	6.24	5	0	6
23	R:R:Y208	7.43	4	0	9
24	R:R:K326	5.915	4	8	8
25	R:R:M330	6.7375	4	8	8
26	R:R:F338	7.27	4	1	9
27	R:R:W342	7.66857	7	1	8
28	R:R:F345	12.045	4	1	8
29	R:R:F346	10.298	5	1	7
30	R:R:W370	9.7	4	1	8
31	R:R:Y373	5.92	5	1	8
32	R:R:N379	6.12	5	1	9
33	R:R:I382	4.59	4	0	8
34	R:R:Y383	6.095	6	1	9
35	R:R:T384	5.94	4	2	8
36	R:R:F390	9.59	5	2	9
37	R:R:F394	6.265	4	2	9
38	R:R:I397	3.76	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:T369	11.3447	5.43	Yes	No	0	0	6
2	R:R:W370	R:R:Y36	15.6226	12.54	Yes	Yes	1	8	7
3	L:L:?1	R:R:Y373	22.7115	4.32	Yes	Yes	1	0	8
4	L:L:?1	R:R:C114	67.4641	8.19	Yes	No	0	0	7
5	R:R:C114	R:R:W342	68.0716	5.22	No	Yes	0	7	8
6	R:R:N375	R:R:W342	100	10.17	No	Yes	0	9	8
7	R:R:N375	R:R:N379	99.3578	8.17	No	Yes	0	9	9
8	R:R:D75	R:R:N379	41.9447	4.04	Yes	Yes	1	9	9
9	R:R:D75	R:R:N47	40.3236	4.04	Yes	Yes	0	9	9
10	L:L:?1	R:R:F346	72.4345	8.98	Yes	Yes	1	0	7
11	R:R:F346	R:R:W342	85.3091	4.01	Yes	Yes	1	7	8
12	R:R:A72	R:R:N47	33.6911	4.69	No	Yes	0	9	9
13	R:R:A72	R:R:V50	31.7395	3.39	No	No	0	9	9
14	R:R:T384	R:R:V50	29.7312	6.35	Yes	No	0	8	9
15	R:R:F394	R:R:T384	10.6554	5.19	Yes	Yes	2	9	8
16	R:R:F390	R:R:T384	16.1326	9.08	Yes	Yes	2	9	8
17	R:R:F338	R:R:W342	61.3573	7.02	Yes	Yes	1	9	8
18	R:R:F338	R:R:L121	68.3203	4.87	Yes	No	1	9	8
19	R:R:L121	R:R:Y383	66.3939	7.03	No	Yes	1	8	9
20	R:R:I124	R:R:Y383	58.858	12.09	No	Yes	1	9	9
21	R:R:I124	R:R:L67	60.0762	4.28	No	No	0	9	7
22	R:R:D127	R:R:L67	58.5023	5.43	No	No	0	9	7
23	R:R:D127	R:R:Y138	55.2537	10.34	No	Yes	4	9	8
24	R:R:G141	R:R:Y138	20.3066	5.79	No	Yes	0	4	8
25	R:R:G141	R:R:S146	18.6508	3.71	No	Yes	0	4	8
26	R:R:S146	R:R:T63	20.5364	7.99	Yes	No	0	8	6
27	R:R:T63	R:R:V150	13.7214	4.76	No	No	0	6	7
28	R:R:V150	R:R:Y66	10.2997	1.26	No	No	0	7	5
29	R:R:N379	R:R:Y383	78.0377	4.65	Yes	Yes	1	9	9
30	R:R:R149	R:R:Y138	31.9158	4.12	Yes	Yes	0	7	8
31	R:R:R149	R:R:S146	18.8838	3.95	Yes	Yes	0	7	8
32	R:R:L71	R:R:N379	14.8231	6.87	No	Yes	1	9	9
33	R:R:L71	R:R:N120	15.7737	5.49	No	No	0	9	9
34	L:L:?1	R:R:S192	39.8798	4.43	Yes	No	0	0	8
35	R:R:F188	R:R:S192	38.1768	10.57	Yes	No	0	7	8
36	R:R:F188	R:R:P167	21.6035	4.33	Yes	No	0	7	7
37	R:R:C166	R:R:P167	19.6707	3.77	No	No	0	6	7
38	R:R:C166	R:R:F162	17.7317	8.38	No	No	0	6	6
39	R:R:F162	R:R:M112	15.7863	3.73	No	No	0	6	7
40	R:R:M112	R:R:M113	13.8347	4.33	No	No	0	7	5
41	R:R:L77	R:R:M113	11.8767	5.65	No	No	0	6	5
42	L:L:?1	R:R:F106	51.1899	3.59	Yes	No	0	0	7
43	R:R:F106	R:R:W85	49.6002	14.03	No	No	0	7	7
44	R:R:C102	R:R:W85	47.7556	5.22	No	No	0	4	7
45	R:R:C102	R:R:F98	17.3036	5.59	No	No	3	4	6
46	R:R:F98	R:R:Y88	15.7832	9.28	No	Yes	0	6	6
47	R:R:C102	R:R:W96	28.6043	7.84	No	Yes	3	4	9
48	R:R:C103	R:R:W96	23.2498	6.53	Yes	Yes	3	9	9
49	R:R:C103	R:R:R100	11.8767	8.36	Yes	No	0	9	3
50	R:R:R128	R:R:Y383	35.5358	4.12	No	Yes	1	9	9
51	R:R:R128	R:R:Y208	36.7508	8.23	No	Yes	0	9	9
52	R:R:S125	R:R:Y208	65.2543	5.09	Yes	Yes	0	9	9
53	R:R:V334	R:R:Y383	36.0583	5.05	No	Yes	0	8	9
54	R:R:V334	R:R:Y208	34.4183	6.31	No	Yes	0	8	9
55	R:R:S125	R:R:V207	55.3985	4.85	Yes	No	6	9	7
56	R:R:V207	R:R:Y129	52.172	3.79	No	Yes	0	7	9
57	R:R:V133	R:R:Y129	12.6857	8.83	No	Yes	0	7	9
58	R:R:R210	R:R:Y129	33.134	8.23	No	Yes	0	6	9
59	R:R:R149	R:R:T130	10.4161	14.23	Yes	No	0	7	5
60	R:R:Q139	R:R:S146	13.7214	1.44	No	Yes	0	6	8
61	R:R:H140	R:R:Q139	10.2997	6.18	No	No	0	5	6
62	R:R:R210	R:R:V213	26.4858	2.62	No	No	0	6	5
63	R:R:Q217	R:R:V213	23.1491	2.87	No	No	0	5	5
64	R:R:Q217	R:R:R220	19.8061	2.34	No	No	0	5	6
65	R:R:K216	R:R:R220	16.4568	4.95	No	No	0	6	6
66	R:R:K216	R:R:Y212	13.1012	5.97	No	No	0	6	6
67	R:R:I382	R:R:Y383	18.0937	3.63	Yes	Yes	0	8	9
68	R:R:I333	R:R:I382	12.7078	8.83	No	Yes	0	8	8
69	R:R:I333	R:R:M330	11.0237	2.92	No	Yes	0	8	8
70	R:R:F345	R:R:T368	14.7444	5.19	Yes	No	0	8	6
71	R:R:T348	R:R:T368	13.6269	6.28	No	No	0	6	6
72	R:R:L364	R:R:T348	12.5	4.42	No	No	0	5	6
73	R:R:F345	R:R:F346	17.8922	12.86	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H29	3.79	1	Yes	No	0	4	0	1
L:L:?1	R:R:E90	3.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:G94	10.08	1	Yes	No	0	5	0	1
L:L:?1	R:R:F106	3.59	1	Yes	No	0	7	0	1
L:L:?1	R:R:D110	23.01	1	Yes	No	0	8	0	1
L:L:?1	R:R:V111	14.27	1	Yes	No	0	8	0	1
L:L:?1	R:R:C114	8.19	1	Yes	No	0	7	0	1
L:L:?1	R:R:S192	4.43	1	Yes	No	0	8	0	1
L:L:?1	R:R:F345	23.34	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F346	8.98	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T369	5.43	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y373	4.32	1	Yes	Yes	0	8	0	1
R:R:E90	R:R:H29	9.85	1	No	No	6	4	1	1
R:R:E90	R:R:Y32	6.73	1	No	No	6	5	1	2
R:R:M83	R:R:Y36	4.79	1	Yes	Yes	8	7	2	2
R:R:V86	R:R:Y36	3.79	1	No	Yes	8	7	2	2
R:R:T369	R:R:Y36	3.75	0	No	Yes	6	7	1	2
R:R:Y36	R:R:Y373	4.96	1	Yes	Yes	7	8	2	1
R:R:D110	R:R:V82	5.84	1	No	No	8	8	1	2
R:R:M83	R:R:Y373	10.78	1	Yes	Yes	8	8	2	1
R:R:F106	R:R:W85	14.03	0	No	No	7	7	1	2
R:R:V86	R:R:Y373	3.79	1	No	Yes	8	8	2	1
R:R:D110	R:R:Y373	5.75	1	No	Yes	8	8	1	1
R:R:S165	R:R:V111	6.46	0	No	No	8	8	2	1
R:R:C114	R:R:W342	5.22	0	No	Yes	7	8	1	2
R:R:S196	R:R:T115	9.59	1	Yes	No	8	8	1	2
R:R:F188	R:R:S192	10.57	7	Yes	No	7	8	2	1
R:R:F346	R:R:S193	5.28	1	Yes	No	7	8	1	2
R:R:F197	R:R:W342	4.01	1	Yes	Yes	9	8	2	2
R:R:F197	R:R:F346	20.36	1	Yes	Yes	9	7	2	1
R:R:F346	R:R:W342	4.01	1	Yes	Yes	7	8	1	2
R:R:F345	R:R:F346	12.86	1	Yes	Yes	8	7	1	1
R:R:F345	R:R:H349	6.79	1	Yes	No	8	8	1	2
R:R:F345	R:R:T368	5.19	1	Yes	No	8	6	1	2
L:L:?1	R:R:S196	3.32	1	Yes	Yes	0	8	0	1
R:R:V164	R:R:V195	3.21	1	No	No	7	4	2	2
R:R:G93	R:R:G94	2.11	0	No	No	4	5	2	1
R:R:S196	R:R:V164	1.62	1	Yes	No	8	7	1	2
R:R:S196	R:R:V195	1.62	1	Yes	No	8	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9F33_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	253
Number of Links	278
Number of Hubs	38
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	52
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	71875
Length Of Smallest Path	3
Average Path Length	14.6072
Length of Longest Path	32
Minimum Path Strength	1.195
Average Path Strength	6.41057
Maximum Path Strength	18.425
Minimum Path Correlation	0.7
Average Path Correlation	0.920779
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	40.0257
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8996
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1H
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1H
Name	Molidustat
Synonyms	Molidustat sodium Molidustat
Identifier
Formula	C13 H14 N8 O2
Molecular Weight	314.303
SMILES
PubChem	59603622
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	0
Total Bonds	40
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35462
Sequence	>9F33_nogp_Chain_R H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E R A L Q T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G G V W N F S R I C C D V F V T L D V M M C T A S I N L C A I S I D R Y T A V V M P V H Y Q H G T G Q S S C R R V A L M I T A V W V L A F A V S C P L L F G F N T T G D P T V C S I S N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C Q T C H V S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F R K A F L K I L S C W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9F34	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go1/β1/γ2	3.05	2024-09-18	10.1038/s41467-024-51993-4
	9F34 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	10.1038/s41467-024-51993-4
	9F33	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-	Go1/β1/γ2	3.05	2024-09-18	10.1038/s41467-024-51993-4
	9F33 (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	FOB02-04A	-		3.05	2024-09-18	10.1038/s41467-024-51993-4
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/β1/γ2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol		3.15	2024-03-13	10.1101/2024.02.09.579708
	8JD3	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	HZR; PEF	Gi1/β1/γ2	3.3	2023-06-21	10.1038/s41422-023-00830-2
	8JD3 (No Gprot)	C	Aminoacid	Metabotropic Glutamate	mGlu2; mGlu3	Homo sapiens	Glutamate	HZR; PEF		3.3	2023-06-21	10.1038/s41422-023-00830-2
	8IRT	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-	Gi1/β1/γ2	2.7	2023-06-07	10.1038/s41422-023-00808-0
	8IRT (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Rotigotine	-		2.7	2023-06-07	10.1038/s41422-023-00808-0
	8ID3	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-	Gi1/β1/γ2	3.1	2023-03-15	10.1126/science.add6220
	8ID3 (No Gprot)	A	Lipid	Free Fatty Acid	FFA4	Homo sapiens	9-Hydroxystearic acid	-		3.1	2023-03-15	10.1126/science.add6220
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	-	3.31	2025-02-26	To be published
	7TD3	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-	Gi1/β1/γ2	3	2022-02-09	10.1038/s41467-022-28417-2
	7TD3 (No Gprot)	A	Lipid	Lysophospholipid	S1P₁	Homo sapiens	S1P	-		3	2022-02-09	10.1038/s41467-022-28417-2
	7LD3	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	PubChem 25263603	Gi2/β1/γ2	3.2	2021-09-08	10.1038/s41586-021-03897-2
	7LD3 (No Gprot)	A	Nucleotide	Adenosine	A₁	Homo sapiens	Adenosine	PubChem 25263603		3.2	2021-09-08	10.1038/s41586-021-03897-2
	7CMV	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-	Gi1/β1/γ2	2.7	2021-03-10	10.1016/j.molcel.2021.01.003
	7CMV (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	PD128907	-		2.7	2021-03-10	10.1016/j.molcel.2021.01.003
	7CMU	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-	Gi1/β1/γ2	3	2021-03-10	10.1016/j.molcel.2021.01.003
	7CMU (No Gprot)	A	Amine	Dopamine	D₃	Homo sapiens	Pramipexole	-		3	2021-03-10	10.1016/j.molcel.2021.01.003
	7AD3	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-	Gi1/STE4/γ2	3.3	2020-12-09	10.1038/s41586-020-2994-1
	7AD3 (No Gprot)	D1	Ste2-like	STE2	STE2	Saccharomyces cerevisiae	α-factor mating pheromone	-		3.3	2020-12-09	10.1038/s41586-020-2994-1
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	10.1016/j.bbrc.2020.08.042
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	3PBL	A	Amine	Dopamine	D₃	Homo sapiens	Eticlopride	-	-	2.89	2010-11-03	10.1126/science.1197410

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9F33_nogp.zip

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