Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.51110
2R:R:Y32 4.662515
3R:R:Y36 6.676517
4R:R:L39 4.955417
5R:R:I43 4.795408
6R:R:E57 5.17408
7R:R:L60 4.82439
8R:R:D75 7.5075409
9R:R:M83 5.565408
10R:R:W96 6.52714729
11R:R:C102 4.44424
12R:R:W119 9.826567
13R:R:C122 3.6375467
14R:R:S125 5.66409
15R:R:D127 5.818549
16R:R:Y129 6.165409
17R:R:Y138 7.516548
18R:R:N185 4.4325456
19R:R:F188 7.182557
20R:R:F197 8.8519
21R:R:F201 7.014506
22R:R:Y208 5.715409
23R:R:F338 6.866519
24R:R:W342 7.59571718
25R:R:F345 9.1275418
26R:R:F346 10.37517
27R:R:W370 7.51518
28R:R:Y373 7.05667618
29R:R:N379 6.975419
30R:R:I382 4.2225408
31R:R:Y383 5.89333619
32R:R:F390 7.28286739
33R:R:F394 5.87833639
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:T369 15.94912.84YesNo106
2R:R:T369 R:R:Y36 15.01694.99NoYes167
3L:L:?1 R:R:Y373 31.53110.99YesYes108
4R:R:M83 R:R:Y373 24.758711.97YesYes088
5R:R:L39 R:R:M83 18.39894.24YesYes078
6R:R:I43 R:R:L39 15.96554.28YesYes087
7R:R:D75 R:R:I43 11.70918.4YesYes098
8L:L:?1 R:R:C114 49.063811.69YesNo007
9R:R:C114 R:R:W342 49.20815.22NoYes078
10R:R:F338 R:R:W342 1006.01YesYes198
11R:R:F338 R:R:L121 84.40164.87YesNo198
12R:R:L121 R:R:Y383 81.22587.03NoYes189
13R:R:I124 R:R:Y383 77.55518.46NoYes199
14R:R:I124 R:R:L67 83.71695.71NoNo097
15R:R:D127 R:R:L67 70.5565.43YesNo097
16R:R:D127 R:R:T64 56.28564.34YesNo498
17R:R:T62 R:R:T64 56.71863.14NoNo078
18R:R:N65 R:R:T62 55.55977.31NoNo097
19R:R:F390 R:R:N65 38.9264.83YesNo399
20R:R:F390 R:R:F394 27.6549.65YesYes399
21L:L:?1 R:R:F346 56.54137.34YesYes107
22R:R:F346 R:R:W342 53.72436.01YesYes178
23R:R:L60 R:R:N65 15.42114.12YesNo399
24R:R:I154 R:R:L67 18.48144.28NoNo087
25R:R:I154 R:R:V150 10.23673.07NoNo087
26L:L:?1 R:R:V111 29.196610.98YesNo008
27R:R:S165 R:R:V111 16.1476.46NoNo088
28R:R:M112 R:R:S165 10.38933.07NoNo078
29L:L:?1 R:R:L89 42.48547.42YesNo005
30R:R:L89 R:R:W96 41.46666.83NoYes059
31R:R:F98 R:R:W96 14.11787.02NoYes269
32R:R:F98 R:R:Y88 12.983619.6NoNo066
33R:R:N97 R:R:Y88 11.58953.49NoNo046
34R:R:N97 R:R:V95 10.19144.43NoNo043
35R:R:C103 R:R:W96 14.26217.84NoYes299
36R:R:C103 R:R:R100 12.8978.36NoNo093
37R:R:R100 R:R:T175 11.50293.88NoNo034
38R:R:F338 R:R:T204 24.47415.19YesNo098
39R:R:S125 R:R:T204 23.48437.99YesNo098
40R:R:C122 R:R:S125 10.56263.44YesYes079
41R:R:S125 R:R:V207 17.44624.85YesNo097
42R:R:V207 R:R:Y129 16.00263.79NoYes079
43R:R:L168 R:R:V111 13.04554.47NoNo078
44R:R:F394 R:R:T385 17.13272.59YesNo096
45R:R:F386 R:R:T385 14.26212.59NoNo076
46R:R:F386 R:R:M330 12.80627.46NoNo078
47R:R:K326 R:R:M330 10.09248.64NoNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L89 7.42 1 Yes No 0 5 0 1
L:L:?1 R:R:D110 15.46 1 Yes No 0 8 0 1
L:L:?1 R:R:V111 10.98 1 Yes No 0 8 0 1
L:L:?1 R:R:C114 11.69 1 Yes No 0 7 0 1
L:L:?1 R:R:S196 4.02 1 Yes No 0 8 0 1
L:L:?1 R:R:F345 13.87 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F346 7.34 1 Yes Yes 0 7 0 1
L:L:?1 R:R:P362 4.4 1 Yes No 0 2 0 1
L:L:?1 R:R:Y365 16.49 1 Yes No 0 4 0 1
L:L:?1 R:R:T369 12.84 1 Yes No 0 6 0 1
L:L:?1 R:R:Y373 10.99 1 Yes Yes 0 8 0 1
R:R:V86 R:R:Y36 6.31 0 No Yes 8 7 2 2
R:R:T369 R:R:Y36 4.99 1 No Yes 6 7 1 2
R:R:D110 R:R:V82 7.3 1 No No 8 8 1 2
R:R:V82 R:R:Y373 3.79 1 No Yes 8 8 2 1
R:R:M83 R:R:Y373 11.97 0 Yes Yes 8 8 2 1
R:R:V86 R:R:Y373 3.79 0 No Yes 8 8 2 1
R:R:L89 R:R:W96 6.83 0 No Yes 5 9 1 2
R:R:D110 R:R:Y373 8.05 1 No Yes 8 8 1 1
R:R:S165 R:R:V111 6.46 0 No No 8 8 2 1
R:R:L168 R:R:V111 4.47 0 No No 7 8 2 1
R:R:C114 R:R:W342 5.22 0 No Yes 7 8 1 2
R:R:S196 R:R:T115 7.99 0 No No 8 8 1 2
R:R:F346 R:R:S193 5.28 1 Yes No 7 8 1 2
R:R:F197 R:R:W342 4.01 1 Yes Yes 9 8 2 2
R:R:F197 R:R:F346 21.43 1 Yes Yes 9 7 2 1
R:R:F346 R:R:W342 6.01 1 Yes Yes 7 8 1 2
R:R:F345 R:R:F346 11.79 1 Yes Yes 8 7 1 1
R:R:F345 R:R:H349 5.66 1 Yes No 8 8 1 2
R:R:F345 R:R:T368 5.19 1 Yes No 8 6 1 2
R:R:E363 R:R:P362 6.29 0 No No 1 2 2 1
R:R:T369 R:R:Y373 3.75 1 No Yes 6 8 1 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9F34_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.49
Number of Linked Nodes 249
Number of Links 278
Number of Hubs 33
Number of Links mediated by Hubs 136
Number of Communities 6
Number of Nodes involved in Communities 46
Number of Links involved in Communities 63
Path Summary
Number Of Nodes in MetaPath 48
Number Of Links MetaPath 47
Number of Shortest Paths 43273
Length Of Smallest Path 3
Average Path Length 13.2135
Length of Longest Path 32
Minimum Path Strength 1.195
Average Path Strength 6.45724
Maximum Path Strength 19.1
Minimum Path Correlation 0.7
Average Path Correlation 0.923436
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 45.4334
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.5962
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • regulation of cellular process   • cellular developmental process   • regulation of developmental process   • negative regulation of biological process   • cell development   • regulation of cell differentiation   • regulation of neurogenesis   • regulation of gliogenesis   • regulation of cell development   • regulation of nervous system development   • multicellular organism development   • neurogenesis   • negative regulation of neurogenesis   • gliogenesis   • cell differentiation   • anatomical structure development   • negative regulation of cellular process   • regulation of multicellular organismal process   • negative regulation of nervous system development   • negative regulation of cell differentiation   • system development   • developmental process   • regulation of biological process   • regulation of multicellular organismal development   • negative regulation of developmental process   • regulation of glial cell differentiation   • biological regulation   • nervous system development   • negative regulation of gliogenesis   • negative regulation of cell development   • negative regulation of oligodendrocyte differentiation   • negative regulation of glial cell differentiation   • central nervous system development   • oligodendrocyte differentiation   • glial cell differentiation   • cellular process   • negative regulation of multicellular organismal process   • regulation of oligodendrocyte differentiation   • response to stimulus   • response to chemical   • response to xenobiotic stimulus   • organic anion transport   • carboxylic acid transport   • secretion   • transport   • arachidonate transport   • lipid localization   • lipid transport   • establishment of localization   • organic acid transport   • localization   • arachidonate secretion   • monocarboxylic acid transport   • fatty acid transport   • icosanoid transport   • macromolecule localization   • icosanoid secretion   • long-chain fatty acid transport   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • regulation of protein localization   • negative regulation of transport   • protein localization to extracellular region   • regulation of secretion by cell   • secretion by cell   • negative regulation of secretion   • negative regulation of secretion by cell   • intracellular protein localization   • negative regulation of protein localization   • regulation of transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • protein transport   • behavior   • locomotory behavior   • regulation of cytokinesis   • positive regulation of cell division   • regulation of cell cycle process   • positive regulation of biological process   • cytokinesis   • positive regulation of cell cycle   • regulation of cell division   • positive regulation of cytokinesis   • positive regulation of cell cycle process   • cell division   • cell cycle   • regulation of cell cycle   • positive regulation of cellular process   • cell cycle process   • adult behavior   • behavioral response to cocaine   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • system process   • learning   • learning or memory   • nervous system process   • cognition   • monoamine transport   • nitrogen compound transport   • regulation of catecholamine secretion   • signaling   • organic hydroxy compound transport   • dopamine transport   • cell communication   • catecholamine transport   • signal release   • cell-cell signaling   • dopamine secretion   • catecholamine secretion   • amine transport   • regulation of amine transport   • regulation of dopamine secretion   • import into cell   • cellular localization   • catecholamine uptake   • dopamine uptake involved in synaptic transmission   • synaptic signaling   • establishment of localization in cell   • regulation of dopamine uptake involved in synaptic transmission   • neurotransmitter reuptake   • regulation of neurotransmitter uptake   • trans-synaptic signaling   • regulation of neurotransmitter transport   • neurotransmitter transport   • chemical synaptic transmission   • anterograde trans-synaptic signaling   • neurotransmitter uptake   • synaptic transmission, dopaminergic   • dopamine uptake   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • adenylate cyclase-inhibiting dopamine receptor signaling pathway   • cellular response to stimulus   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • signal transduction   • G protein-coupled dopamine receptor signaling pathway   • cellular response to oxygen-containing compound   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to light stimulus   • visual learning   • visual behavior   • associative learning   • response to radiation   • response to abiotic stimulus   • positive regulation of organelle organization   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of mitotic nuclear division   • positive regulation of mitotic nuclear division   • mitotic cell cycle   • cellular component organization   • regulation of mitotic cell cycle   • cellular component organization or biogenesis   • mitotic nuclear division   • organelle fission   • positive regulation of nuclear division   • regulation of organelle organization   • organelle organization   • nuclear division   • mitotic cell cycle process   • regulation of nuclear division   • regulation of biosynthetic process   • rhythmic process   • circadian regulation of gene expression   • circadian rhythm   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • response to histamine   • amine metabolic process   • catecholamine metabolic process   • phenol-containing compound metabolic process   • dopamine metabolic process   • catechol-containing compound metabolic process   • biogenic amine metabolic process   • startle response   • regulation of response to external stimulus   • neuromuscular process   • negative regulation of response to stimulus   • prepulse inhibition   • response to external stimulus   • regulation of response to stimulus   • negative regulation of response to external stimulus   • regulation of potassium ion transport   • regulation of monoatomic ion transport   • metal ion transport   • monoatomic ion transport   • potassium ion transport   • monoatomic cation transport   • regulation of metal ion transport   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • negative regulation of signaling   • negative regulation of intracellular signal transduction   • negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • regulation of signal transduction   • intracellular signal transduction   • negative regulation of cell communication   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • negative regulation of signal transduction   • regulation of cell communication   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • multicellular organismal movement   • musculoskeletal movement   • reflex   • musculoskeletal movement, spinal reflex action   • modulation of chemical synaptic transmission   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • negative regulation of synaptic transmission   • regulation of trans-synaptic signaling   • negative regulation of synaptic transmission, glutamatergic   • response to morphine   • response to isoquinoline alkaloid   • regulation of biological quality   • negative regulation of cytosolic calcium ion concentration   • biological process involved in intraspecies interaction between organisms   • social behavior   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of dopamine receptor signaling pathway   • positive regulation of response to stimulus   • regulation of G protein-coupled receptor signaling pathway   • positive regulation of G protein-coupled receptor signaling pathway   • positive regulation of dopamine receptor signaling pathway   • positive regulation of signaling   • acid secretion   • adenylate cyclase-activating dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • negative adaptation of signaling pathway   • receptor internalization   • desensitization of G protein-coupled receptor signaling pathway   • negative regulation of G protein-coupled receptor signaling pathway   • vesicle-mediated transport   • G protein-coupled receptor internalization   • adaptation of signaling pathway   • receptor-mediated endocytosis   • endocytosis   • circulatory system process   • regulation of blood pressure   • negative regulation of blood pressure   • blood circulation   • phospholipase C-activating dopamine receptor signaling pathway   • phospholipase C-activating G protein-coupled receptor signaling pathway   • bioluminescence   • generation of precursor metabolites and energy   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to stress   • response to oxygen levels   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • cell body   • mu-type opioid receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • cation binding   • metal ion binding   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • heart process   • regulation of heart contraction   • regulation of system process   • regulation of blood circulation   • heart contraction   • membrane docking   • organelle localization by membrane tethering   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • negative regulation of hormone secretion   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • regulation of hormone secretion   • regulation of peptide secretion   • hormone secretion   • negative regulation of peptide secretion   • peptide secretion   • regulation of peptide transport   • peptide transport   • negative regulation of insulin secretion   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • insulin secretion   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • postsynapse   • postsynaptic membrane   • synaptic membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • GABA-ergic synapse   • glutamatergic synapse
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP35462
Sequence
>9F34_nogp_Chain_R
YALSYCALI LAIVFGNGL VCMAVLKER ALQTTTNYL VVSLAVADL 
LVATLVMPW VVYLEVTGG VWNFSRICC DVFVTLDVM MCTASINLC 
AISIDRYTA VVMPVHYQH GTGQSSCRR VALMITAVW VLAFAVSCP 
LLFGFNTTG DPTVCSISN PDFVIYSSV VSFYLPFGV TVLVYARIY 
VVLKQRRRK RIREKKATQ MVAIVLGAF IVCWLPFFL THVLNTHCQ 
TCHVSPELY SATTWLGYV NSALNPVIY TTFNIEFRK AFLKILSCW


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3PBLAAmineDopamineD3Homo sapiensEticlopride--2.892010-11-03doi.org/10.1126/science.1197410
6D32FProteinFrizzledSMOXenopus laevisCyclopamineCyclopamine-3.752018-05-23doi.org/10.1016/j.cell.2018.04.029
6D35FProteinFrizzledSMOXenopus laevis-Cholesterol-3.92018-05-23doi.org/10.1016/j.cell.2018.04.029
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7AD3D1Ste2-likeSTE2STE2; STE2Saccharomyces cerevisiaeα-factor mating pheromone-Gi1/STE4/γ23.32020-12-09doi.org/10.1038/s41586-020-2994-1
7AD3 (No Gprot) D1Ste2-likeSTE2STE2; STE2Saccharomyces cerevisiaeα-factor mating pheromone-3.32020-12-09doi.org/10.1038/s41586-020-2994-1
7CMUAAmineDopamineD3Homo sapiensPramipexole-Gi1/β1/γ232021-03-10doi.org/10.1016/j.molcel.2021.01.003
7CMU (No Gprot) AAmineDopamineD3Homo sapiensPramipexole-32021-03-10doi.org/10.1016/j.molcel.2021.01.003
7CMVAAmineDopamineD3Homo sapiensPD128907-Gi1/β1/γ22.72021-03-10doi.org/10.1016/j.molcel.2021.01.003
7CMV (No Gprot) AAmineDopamineD3Homo sapiensPD128907-2.72021-03-10doi.org/10.1016/j.molcel.2021.01.003
7LD3ANucleotideAdenosineA1Homo sapiensAdenosineMIPS521Gi2/β1/γ23.22021-09-08doi.org/10.1038/s41586-021-03897-2
7LD3 (No Gprot) ANucleotideAdenosineA1Homo sapiensAdenosineMIPS5213.22021-09-08doi.org/10.1038/s41586-021-03897-2
7TD3ALipidLysophospholipidS1P1Homo sapiensS1P-Gi1/β1/γ232022-02-09doi.org/10.1038/s41467-022-28417-2
7TD3 (No Gprot) ALipidLysophospholipidS1P1Homo sapiensS1P-32022-02-09doi.org/10.1038/s41467-022-28417-2
8ID3ALipidFree Fatty AcidFFA4Homo sapiens9-Hydroxystearic acid-Gi1/β1/γ23.12023-03-15doi.org/10.1126/science.add6220
8ID3 (No Gprot) ALipidFree Fatty AcidFFA4Homo sapiens9-Hydroxystearic acid-3.12023-03-15doi.org/10.1126/science.add6220
8IRTAAmineDopamineD3Homo sapiensRotigotine-Gi1/β1/γ22.72023-06-07doi.org/10.1038/s41422-023-00808-0
8IRT (No Gprot) AAmineDopamineD3Homo sapiensRotigotine-2.72023-06-07doi.org/10.1038/s41422-023-00808-0
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateJNJ-40411813Gi1/β1/γ23.32023-06-21doi.org/10.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateJNJ-404118133.32023-06-21doi.org/10.1038/s41422-023-00830-2
9F33AAmineDopamineD3Homo sapiensFOB02-04A-Go/β1/γ23.052024-09-18doi.org/10.1038/s41467-024-51993-4
9F33 (No Gprot) AAmineDopamineD3Homo sapiensFOB02-04A-3.052024-09-18doi.org/10.1038/s41467-024-51993-4
9F34AAmineDopamineD3Homo sapiensFOB02-04A-Go/β1/γ23.052024-09-18doi.org/10.1038/s41467-024-51993-4
9F34 (No Gprot) AAmineDopamineD3Homo sapiensFOB02-04A-3.052024-09-18doi.org/10.1038/s41467-024-51993-4
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100--3.312025-02-26doi.org/10.1073/pnas.2425795122
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100-3.152024-03-13doi.org/10.1101/2024.02.09.579708




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