psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D114	15.33	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y115	13.24	Yes	Yes	1	0	9
3	L:L:?1	R:R:C118	4.48	Yes	No	1	0	8
4	L:L:?1	R:R:Y167	4.41	Yes	Yes	1	0	8
5	L:L:?1	R:R:Y374	17.65	Yes	Yes	1	0	9
6	L:L:?1	R:R:F398	16.05	Yes	Yes	1	0	7
7	L:L:?1	R:R:L401	7.82	Yes	No	1	0	8
8	L:L:?1	R:R:W402	6.43	Yes	Yes	1	0	8
9	R:R:A31	R:R:T34	5.03	No	No	0	4	5
10	R:R:A32	R:R:W33	3.89	No	No	0	4	3
11	R:R:L37	R:R:W33	4.56	No	No	0	5	3
12	R:R:M41	R:R:W399	13.96	No	No	0	7	9
13	R:R:L44	R:R:W399	4.56	No	No	0	7	9
14	R:R:A406	R:R:L44	4.73	No	No	0	7	7
15	R:R:I45	R:R:I88	5.89	No	Yes	0	7	9
16	R:R:G51	R:R:L54	5.13	No	No	0	9	8
17	R:R:D80	R:R:N52	12.12	No	Yes	2	9	9
18	R:R:F81	R:R:N52	3.62	No	Yes	0	8	9
19	R:R:N52	R:R:P409	8.15	Yes	No	2	9	9
20	R:R:A77	R:R:V55	3.39	No	No	0	9	9
21	R:R:F59	R:R:L65	7.31	No	No	0	8	9
22	R:R:F59	R:R:F71	4.29	No	No	0	8	6
23	R:R:F59	R:R:L74	13.4	No	No	0	8	8
24	R:R:D62	R:R:R421	8.34	No	No	0	8	6
25	R:R:A422	R:R:D62	4.63	No	No	0	9	8
26	R:R:R421	R:R:S64	3.95	No	No	0	6	7
27	R:R:L65	R:R:N70	10.98	No	Yes	0	9	9
28	R:R:F71	R:R:R66	3.21	No	No	0	6	8
29	R:R:N70	R:R:T67	11.7	Yes	No	0	9	8
30	R:R:F72	R:R:Q68	10.54	Yes	No	0	9	8
31	R:R:A152	R:R:Q68	6.06	No	No	0	8	8
32	R:R:D131	R:R:N69	12.12	No	No	4	9	8
33	R:R:N69	R:R:Y142	5.81	No	Yes	4	8	9
34	R:R:C415	R:R:N70	3.15	No	Yes	0	8	9
35	R:R:H416	R:R:N70	7.65	No	Yes	0	9	9
36	R:R:F71	R:R:T149	5.19	No	No	0	6	6
37	R:R:F72	R:R:L127	13.4	Yes	No	0	9	8
38	R:R:D131	R:R:F72	4.78	No	Yes	0	9	9
39	R:R:F72	R:R:M156	4.98	Yes	No	0	9	9
40	R:R:I128	R:R:L73	4.28	No	No	0	9	8
41	R:R:L73	R:R:P413	3.28	No	No	0	8	9
42	R:R:C415	R:R:L73	3.17	No	No	0	8	8
43	R:R:N124	R:R:N75	6.81	No	No	0	8	9
44	R:R:M156	R:R:N75	11.22	No	No	0	9	9
45	R:R:N75	R:R:W160	4.52	No	No	0	9	9
46	R:R:L76	R:R:N124	4.12	No	No	0	9	8
47	R:R:L76	R:R:N408	5.49	No	No	2	9	9
48	R:R:L76	R:R:P413	6.57	No	No	2	9	9
49	R:R:S120	R:R:S79	4.89	No	No	0	8	8
50	R:R:S121	R:R:S79	4.89	No	No	0	9	8
51	R:R:D80	R:R:S405	4.42	No	No	0	9	9
52	R:R:D80	R:R:P409	6.44	No	No	2	9	9
53	R:R:A85	R:R:F81	4.16	No	No	0	6	8
54	R:R:F86	R:R:L82	7.31	No	No	0	6	6
55	R:R:L117	R:R:L82	8.3	No	No	0	7	6
56	R:R:L117	R:R:V83	7.45	No	No	0	7	9
57	R:R:G84	R:R:I88	3.53	No	Yes	0	9	9
58	R:R:C87	R:R:I88	3.27	Yes	Yes	1	9	9
59	R:R:C87	R:R:W110	3.92	Yes	Yes	1	9	6
60	R:R:C87	R:R:D114	10.89	Yes	Yes	1	9	9
61	R:R:C87	R:R:W402	9.14	Yes	Yes	1	9	8
62	R:R:I88	R:R:P89	3.39	Yes	No	0	9	9
63	R:R:I88	R:R:W402	15.27	Yes	Yes	1	9	8
64	R:R:L90	R:R:W110	5.69	No	Yes	0	6	6
65	R:R:Y91	R:R:Y94	9.93	Yes	No	0	8	6
66	R:R:V95	R:R:Y91	5.05	No	Yes	0	6	8
67	R:R:W110	R:R:Y91	12.54	Yes	Yes	1	6	8
68	R:R:F398	R:R:Y91	8.25	Yes	Yes	1	7	8
69	R:R:W402	R:R:Y91	6.75	Yes	Yes	1	8	8
70	R:R:P93	R:R:V92	3.53	No	No	0	7	7
71	R:R:P93	R:R:T101	3.5	No	No	0	7	5
72	R:R:W100	R:R:Y94	9.65	Yes	No	0	9	6
73	R:R:T101	R:R:T97	4.71	No	No	0	5	5
74	R:R:E185	R:R:R99	17.45	Yes	No	0	1	4
75	R:R:F102	R:R:W100	8.02	No	Yes	5	8	9
76	R:R:L106	R:R:W100	3.42	No	Yes	5	5	9
77	R:R:C107	R:R:W100	9.14	No	Yes	0	9	9
78	R:R:F102	R:R:L106	8.53	No	No	5	8	5
79	R:R:E175	R:R:R104	10.47	No	No	0	5	4
80	R:R:R104	R:R:S181	9.22	No	No	0	4	4
81	R:R:G105	R:R:K108	6.97	No	No	0	5	7
82	R:R:C107	R:R:C188	7.28	No	No	0	9	9
83	R:R:L111	R:R:W110	6.83	No	Yes	0	7	6
84	R:R:D114	R:R:W110	3.35	Yes	Yes	1	9	6
85	R:R:F398	R:R:W110	4.01	Yes	Yes	1	7	6
86	R:R:L111	R:R:Y115	4.69	No	Yes	0	7	9
87	R:R:I171	R:R:V112	4.61	Yes	No	0	7	8
88	R:R:C118	R:R:D114	3.11	No	Yes	1	8	9
89	R:R:D114	R:R:W402	5.58	Yes	Yes	1	9	8
90	R:R:Y115	R:R:Y167	25.81	Yes	Yes	1	9	8
91	R:R:I171	R:R:Y115	3.63	Yes	Yes	1	7	9
92	R:R:F164	R:R:L116	7.31	No	No	0	7	8
93	R:R:A163	R:R:T119	3.36	No	No	0	8	9
94	R:R:T119	R:R:Y167	4.99	No	Yes	0	9	8
95	R:R:N124	R:R:S120	4.47	No	No	0	8	8
96	R:R:S120	R:R:W160	9.88	No	No	0	8	9
97	R:R:F367	R:R:I125	5.02	Yes	No	0	9	8
98	R:R:I125	R:R:Y412	6.04	No	Yes	0	8	9
99	R:R:P210	R:R:V126	3.53	No	No	0	9	8
100	R:R:K155	R:R:L127	5.64	No	No	0	7	8
101	R:R:I128	R:R:R132	6.26	No	No	0	9	9
102	R:R:I128	R:R:Y412	7.25	No	Yes	0	9	9
103	R:R:S129	R:R:V214	6.46	No	No	0	9	9
104	R:R:S129	R:R:Y412	5.09	No	Yes	0	9	9
105	R:R:L134	R:R:Y130	12.89	No	No	0	5	7
106	R:R:F217	R:R:Y130	9.28	Yes	No	0	8	7
107	R:R:D131	R:R:Y142	9.2	No	Yes	4	9	9
108	R:R:F133	R:R:T137	9.08	No	No	0	9	8
109	R:R:F133	R:R:F217	12.86	No	Yes	0	9	8
110	R:R:F133	R:R:S220	3.96	No	No	0	9	8
111	R:R:S135	R:R:Y142	8.9	No	Yes	0	9	9
112	R:R:I221	R:R:V136	6.14	No	No	0	9	8
113	R:R:Q145	R:R:S141	4.33	No	No	0	6	5
114	R:R:N146	R:R:Y142	12.79	No	Yes	0	8	9
115	R:R:D148	R:R:R151	3.57	No	No	0	8	7
116	R:R:R151	R:R:R154	6.4	No	No	0	7	3
117	R:R:K155	R:R:R154	11.14	No	No	0	7	3
118	R:R:L158	R:R:L162	4.15	No	No	0	4	6
119	R:R:F164	R:R:L165	6.09	No	No	0	7	5
120	R:R:I171	R:R:Y167	4.84	Yes	Yes	1	7	8
121	R:R:G168	R:R:P169	4.06	No	No	0	6	8
122	R:R:E191	R:R:I171	4.1	No	Yes	0	8	7
123	R:R:L177	R:R:W174	4.56	No	No	0	4	5
124	R:R:S178	R:R:W174	4.94	No	No	0	3	5
125	R:R:F192	R:R:W174	25.05	No	No	0	7	5
126	R:R:E175	R:R:E191	10.15	No	No	0	5	8
127	R:R:G179	R:R:S178	3.71	No	No	0	5	3
128	R:R:I183	R:R:S182	3.1	Yes	No	0	4	5
129	R:R:H187	R:R:S182	4.18	No	No	0	3	5
130	R:R:I183	R:R:P184	3.39	Yes	No	3	4	3
131	R:R:E185	R:R:I183	6.83	Yes	Yes	3	1	4
132	R:R:G186	R:R:I183	3.53	No	Yes	3	3	4
133	R:R:E185	R:R:P184	9.43	Yes	No	3	1	3
134	R:R:E185	R:R:G186	3.27	Yes	No	3	1	3
135	R:R:Y189	R:R:Y394	13.9	No	Yes	0	4	4
136	R:R:F398	R:R:Y189	8.25	Yes	No	0	7	4
137	R:R:F192	R:R:N195	19.33	No	No	0	7	6
138	R:R:F193	R:R:Y194	16.5	No	No	1	5	6
139	R:R:F193	R:R:R381	20.31	No	Yes	1	5	4
140	R:R:F193	R:R:Y394	8.25	No	Yes	1	5	4
141	R:R:R381	R:R:Y194	7.2	Yes	No	1	4	6
142	R:R:H385	R:R:Y194	9.8	No	No	0	4	6
143	R:R:N195	R:R:Y197	6.98	No	No	0	6	5
144	R:R:I200	R:R:W196	4.7	No	No	0	7	5
145	R:R:A382	R:R:W196	3.89	No	No	0	7	5
146	R:R:F198	R:R:L199	3.65	No	No	0	7	8
147	R:R:L199	R:R:M378	4.24	No	No	0	8	8
148	R:R:I200	R:R:I379	5.89	No	No	0	7	6
149	R:R:M378	R:R:S203	3.07	No	No	0	8	8
150	R:R:I379	R:R:S203	4.64	No	No	0	6	8
151	R:R:L205	R:R:T204	4.42	No	No	0	6	6
152	R:R:F208	R:R:T204	5.19	No	No	0	7	6
153	R:R:E206	R:R:T375	5.64	No	No	0	8	8
154	R:R:F207	R:R:F208	5.36	Yes	No	0	9	7
155	R:R:F207	R:R:F211	8.57	Yes	No	1	9	8
156	R:R:F207	R:R:F367	6.43	Yes	Yes	1	9	9
157	R:R:F207	R:R:W371	4.01	Yes	Yes	1	9	8
158	R:R:A372	R:R:F207	4.16	No	Yes	0	7	9
159	R:R:F207	R:R:T375	11.67	Yes	No	0	9	8
160	R:R:P210	R:R:T209	3.5	No	No	0	9	7
161	R:R:F211	R:R:T215	3.89	No	No	0	8	6
162	R:R:F211	R:R:F367	4.29	No	Yes	1	8	9
163	R:R:N218	R:R:V214	4.43	No	No	0	9	9
164	R:R:V214	R:R:V364	4.81	No	No	0	9	8
165	R:R:F216	R:R:F217	4.29	No	Yes	0	5	8
166	R:R:F216	R:R:S220	7.93	No	No	0	5	8
167	R:R:L360	R:R:N218	15.1	No	No	0	8	9
168	R:R:L219	R:R:L223	5.54	No	No	0	4	5
169	R:R:R354	R:R:Y222	4.12	No	No	0	7	7
170	R:R:Q226	R:R:R227	5.84	No	No	6	7	5
171	R:R:Q226	R:R:R230	11.68	No	No	6	7	6
172	R:R:R227	R:R:R230	4.26	No	No	6	5	6
173	R:R:R349	R:R:T229	5.17	Yes	No	0	6	6
174	R:R:D353	R:R:T229	8.67	No	No	0	9	6
175	R:R:D234	R:R:R230	4.76	No	No	0	4	6
176	R:R:R232	R:R:R349	10.66	No	Yes	0	5	6
177	R:R:L233	R:R:R347	3.64	No	No	0	5	5
178	R:R:R347	R:R:R349	4.26	No	Yes	0	5	6
179	R:R:F348	R:R:R352	4.28	No	No	0	4	8
180	R:R:R349	R:R:R352	8.53	Yes	No	0	6	8
181	R:R:D353	R:R:L350	4.07	No	No	0	9	6
182	R:R:L350	R:R:R354	6.07	No	No	0	6	7
183	R:R:K355	R:R:R352	6.19	No	No	0	8	8
184	R:R:L360	R:R:V356	4.47	No	No	0	8	8
185	R:R:I363	R:R:L411	5.71	No	No	0	8	9
186	R:R:I363	R:R:Y412	9.67	No	Yes	0	8	9
187	R:R:I366	R:R:L411	4.28	No	No	0	7	9
188	R:R:F367	R:R:W371	10.02	Yes	Yes	1	9	8
189	R:R:C370	R:R:L400	4.76	No	No	0	8	9
190	R:R:C370	R:R:N404	7.87	No	No	0	8	9
191	R:R:L401	R:R:W371	18.22	No	Yes	1	8	8
192	R:R:N404	R:R:W371	10.17	No	Yes	0	9	8
193	R:R:L400	R:R:P373	4.93	No	No	0	9	9
194	R:R:M378	R:R:Y374	4.79	No	Yes	0	8	9
195	R:R:Y374	R:R:Y394	5.96	Yes	Yes	1	9	4
196	R:R:S397	R:R:Y374	5.09	No	Yes	0	7	9
197	R:R:F398	R:R:Y374	9.28	Yes	Yes	1	7	9
198	R:R:L401	R:R:Y374	4.69	No	Yes	1	8	9
199	R:R:L377	R:R:Y394	3.52	No	Yes	0	7	4
200	R:R:R381	R:R:V389	7.85	Yes	No	0	4	5
201	R:R:R381	R:R:Y394	7.2	Yes	Yes	1	4	4
202	R:R:C384	R:R:H387	4.42	No	No	0	7	4
203	R:R:C384	R:R:C388	7.28	No	No	0	7	8
204	R:R:G386	R:R:V389	3.68	No	No	0	3	5
205	R:R:P390	R:R:V389	3.53	No	No	0	7	5
206	R:R:P390	R:R:W393	9.46	No	No	0	7	6
207	R:R:D391	R:R:Y392	11.49	No	No	0	2	3
208	R:R:E395	R:R:Y392	6.73	No	No	0	6	3
209	R:R:F398	R:R:W402	6.01	Yes	Yes	1	7	8
210	R:R:W399	R:R:W402	7.5	No	Yes	0	9	8
211	R:R:N408	R:R:P409	3.26	No	No	2	9	9
212	R:R:N408	R:R:P413	9.77	No	No	2	9	9
213	R:R:R421	R:R:S418	6.59	No	No	0	6	8
214	R:R:F419	R:R:F423	11.79	Yes	No	0	9	9
215	R:R:F423	R:R:R420	5.34	No	No	0	9	9
216	R:R:M56	R:R:V60	3.04	No	No	0	7	5
217	R:R:M156	R:R:V153	3.04	No	No	0	9	5
218	R:R:F207	R:R:G368	3.01	Yes	No	1	9	7
219	R:R:F367	R:R:G368	3.01	Yes	No	1	9	7
220	R:R:L65	R:R:S418	3	No	No	0	9	8
221	R:R:L117	R:R:S79	3	No	No	0	7	8
222	R:R:L50	R:R:V46	2.98	No	No	0	5	5
223	R:R:L96	R:R:V92	2.98	No	No	0	7	7
224	R:R:L109	R:R:V113	2.98	No	No	0	6	6
225	R:R:L157	R:R:V153	2.98	No	No	0	5	5
226	R:R:L411	R:R:V362	2.98	No	No	0	9	8
227	R:R:N224	R:R:V136	2.96	No	No	0	7	8
228	R:R:L212	R:R:T215	2.95	No	No	0	5	6
229	R:R:N52	R:R:T48	2.92	Yes	No	0	9	9
230	R:R:W196	R:R:Y197	2.89	No	No	0	5	5
231	R:R:P184	R:R:R104	2.88	No	No	0	3	4
232	R:R:I221	R:R:L360	2.85	No	No	0	9	8
233	R:R:I380	R:R:L377	2.85	No	No	0	7	7
234	R:R:K108	R:R:L172	2.82	No	No	0	7	5
235	R:R:D353	R:R:I225	2.8	No	No	0	9	8
236	R:R:C415	R:R:F419	2.79	No	Yes	0	8	9
237	R:R:A58	R:R:F419	2.77	No	Yes	0	9	9
238	R:R:D234	R:R:L233	2.71	No	No	0	4	5
239	R:R:E175	R:R:K108	2.7	No	No	0	5	7
240	R:R:A357	R:R:Y222	2.67	No	No	0	8	7
241	R:R:L223	R:R:Q226	2.66	No	No	0	5	7
242	R:R:F217	R:R:S129	2.64	Yes	No	0	8	9
243	R:R:R138	R:R:S141	2.64	No	No	0	6	5
244	R:R:F217	R:R:S213	2.64	Yes	No	0	8	8
245	R:R:F81	R:R:V49	2.62	No	No	0	8	7
246	R:R:F123	R:R:V159	2.62	No	No	0	7	8
247	R:R:R99	R:R:T97	2.59	No	No	0	4	5
248	R:R:F123	R:R:T119	2.59	No	No	0	7	9
249	R:R:L134	R:R:R138	2.43	No	No	0	5	6
250	R:R:N224	R:R:R227	2.41	No	No	0	7	5
251	R:R:G179	R:R:G180	2.11	No	No	0	5	2
252	R:R:G168	R:R:V112	1.84	No	No	0	6	8
253	R:R:G51	R:R:L50	1.71	No	No	0	9	5
254	R:R:G168	R:R:L116	1.71	No	No	0	6	8
255	R:R:G147	R:R:N146	1.7	No	No	0	6	8
256	R:R:D234	R:R:G235	1.68	No	No	0	4	4
257	R:R:C388	R:R:I380	1.64	No	No	0	8	7
258	R:R:S365	R:R:V364	1.62	No	No	0	6	8
259	R:R:V112	R:R:V113	1.6	No	No	0	8	6
260	R:R:S213	R:R:T209	1.6	No	No	0	8	7
261	R:R:A38	R:R:L96	1.58	No	No	0	6	7
262	R:R:A190	R:R:L111	1.58	No	No	0	7	7
263	R:R:A403	R:R:L400	1.58	No	No	0	7	9
264	R:R:A77	R:R:N52	1.56	No	Yes	0	9	9
265	R:R:A61	R:R:D62	1.54	No	No	0	7	8
266	R:R:I366	R:R:V407	1.54	No	No	0	7	7
267	R:R:I200	R:R:T201	1.52	No	No	0	7	6
268	R:R:F102	R:R:G103	1.51	No	No	0	8	8
269	R:R:L369	R:R:S365	1.5	No	No	0	5	6
270	R:R:L162	R:R:V161	1.49	No	No	0	6	5
271	R:R:L376	R:R:T375	1.47	No	No	0	7	8
272	R:R:I78	R:R:M56	1.46	No	No	0	8	7
273	R:R:I78	R:R:L74	1.43	No	No	0	8	8
274	R:R:I78	R:R:L82	1.43	No	No	0	8	6
275	R:R:K155	R:R:L158	1.41	No	No	0	7	4
276	R:R:L37	R:R:L40	1.38	No	No	0	5	5
277	R:R:A122	R:R:W371	1.3	No	Yes	0	9	8
278	R:R:F419	R:R:L414	1.22	Yes	No	0	9	7
279	R:R:L231	R:R:R228	1.21	No	No	0	5	8
280	R:R:T396	R:R:W393	1.21	No	No	0	5	6
281	R:R:E395	R:R:Y394	1.12	No	Yes	0	6	4
282	R:R:R228	R:R:R349	1.07	No	Yes	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.6763	8	1	0
2	R:R:N52	5.674	5	2	9
3	R:R:N70	8.37	4	0	9
4	R:R:F72	8.425	4	0	9
5	R:R:C87	6.805	4	1	9
6	R:R:I88	6.27	5	1	9
7	R:R:Y91	8.504	5	1	8
8	R:R:W100	7.5575	4	5	9
9	R:R:W110	6.05667	6	1	6
10	R:R:D114	7.652	5	1	9
11	R:R:Y115	11.8425	4	1	9
12	R:R:Y142	9.175	4	4	9
13	R:R:Y167	10.0125	4	1	8
14	R:R:I171	4.295	4	1	7
15	R:R:I183	4.2125	4	3	4
16	R:R:E185	9.245	4	3	1
17	R:R:F207	6.17286	7	1	9
18	R:R:F217	6.342	5	0	8
19	R:R:R349	5.938	5	0	6
20	R:R:F367	5.754	5	1	9
21	R:R:W371	8.744	5	1	8
22	R:R:Y374	7.91	6	1	9
23	R:R:R381	10.64	4	1	4
24	R:R:Y394	6.65833	6	1	4
25	R:R:F398	8.64167	6	1	7
26	R:R:W402	8.09714	7	1	8
27	R:R:Y412	7.0125	4	0	9
28	R:R:F419	4.6425	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W402	18.6893	6.43	Yes	Yes	1	0	8
2	L:L:?1	R:R:L401	66.6653	7.82	Yes	No	1	0	8
3	R:R:L401	R:R:W371	100	18.22	No	Yes	1	8	8
4	R:R:F367	R:R:W371	91.3792	10.02	Yes	Yes	1	9	8
5	R:R:F367	R:R:I125	94.8325	5.02	Yes	No	0	9	8
6	R:R:I125	R:R:Y412	94.6192	6.04	No	Yes	0	8	9
7	R:R:I128	R:R:Y412	70.541	7.25	No	Yes	0	9	9
8	R:R:I128	R:R:L73	69.1875	4.28	No	No	0	9	8
9	R:R:L73	R:R:P413	46.3807	3.28	No	No	0	8	9
10	R:R:N408	R:R:P413	11.7705	9.77	No	No	2	9	9
11	R:R:N408	R:R:P409	12.1765	3.26	No	No	2	9	9
12	R:R:C415	R:R:L73	28.6265	3.17	No	No	0	8	8
13	R:R:C415	R:R:N70	22.3639	3.15	No	Yes	0	8	9
14	R:R:L65	R:R:N70	19.1158	10.98	No	Yes	0	9	9
15	R:R:F59	R:R:L65	11.3645	7.31	No	No	0	8	9
16	R:R:L76	R:R:P413	33.7161	6.57	No	No	2	9	9
17	R:R:L76	R:R:N124	34.3231	4.12	No	No	0	9	8
18	R:R:N124	R:R:N75	25.8992	6.81	No	No	0	8	9
19	R:R:M156	R:R:N75	25.0051	11.22	No	No	0	9	9
20	R:R:F72	R:R:M156	21.4617	4.98	Yes	No	0	9	9
21	R:R:F72	R:R:L127	10.3966	13.4	Yes	No	0	9	8
22	R:R:N124	R:R:S120	10.0357	4.47	No	No	0	8	8
23	L:L:?1	R:R:F398	11.2209	16.05	Yes	Yes	1	0	7
24	R:R:F398	R:R:Y91	16.0317	8.25	Yes	Yes	1	7	8
25	R:R:Y91	R:R:Y94	20.4077	9.93	Yes	No	0	8	6
26	L:L:?1	R:R:Y115	30.2711	13.24	Yes	Yes	1	0	9
27	R:R:I171	R:R:Y115	29.5657	3.63	Yes	Yes	1	7	9
28	R:R:E191	R:R:I171	41.3157	4.1	No	Yes	0	8	7
29	R:R:E175	R:R:E191	39.4168	10.15	No	No	0	5	8
30	R:R:E175	R:R:R104	31.8501	10.47	No	No	0	5	4
31	R:R:P184	R:R:R104	28.04	2.88	No	No	0	3	4
32	R:R:E185	R:R:P184	18.029	9.43	Yes	No	3	1	3
33	R:R:E185	R:R:R99	14.1451	17.45	Yes	No	0	1	4
34	R:R:R99	R:R:T97	12.1355	2.59	No	No	0	4	5
35	R:R:T101	R:R:T97	10.1177	4.71	No	No	0	5	5
36	L:L:?1	R:R:Y167	32.4242	4.41	Yes	Yes	1	0	8
37	R:R:I171	R:R:Y167	28.3476	4.84	Yes	Yes	1	7	8
38	R:R:W100	R:R:Y94	17.5163	9.65	Yes	No	0	9	6
39	R:R:I171	R:R:V112	16.249	4.61	Yes	No	0	7	8
40	R:R:G168	R:R:V112	10.2284	1.84	No	No	0	6	8
41	R:R:S129	R:R:Y412	51.9378	5.09	No	Yes	0	9	9
42	R:R:F217	R:R:S129	18.0823	2.64	Yes	No	0	8	9
43	R:R:S129	R:R:V214	37.0422	6.46	No	No	0	9	9
44	R:R:N218	R:R:V214	32.9902	4.43	No	No	0	9	9
45	R:R:L360	R:R:N218	31.9567	15.1	No	No	0	8	9
46	R:R:I221	R:R:L360	29.9471	2.85	No	No	0	9	8
47	R:R:I221	R:R:V136	28.889	6.14	No	No	0	9	8
48	L:L:?1	R:R:Y374	12.9804	17.65	Yes	Yes	1	0	9
49	R:R:M378	R:R:Y374	19.8663	4.79	No	Yes	0	8	9
50	R:R:M378	R:R:S203	16.532	3.07	No	No	0	8	8
51	R:R:I379	R:R:S203	15.4042	4.64	No	No	0	6	8
52	R:R:I200	R:R:I379	14.2681	5.89	No	No	0	7	6
53	R:R:I200	R:R:W196	11.9715	4.7	No	No	0	7	5
54	R:R:Y374	R:R:Y394	23.3851	5.96	Yes	Yes	1	9	4
55	R:R:R381	R:R:Y394	10.2038	7.2	Yes	Yes	1	4	4
56	R:R:N224	R:R:V136	27.9293	2.96	No	No	0	7	8
57	R:R:N224	R:R:R227	26.8589	2.41	No	No	0	7	5
58	R:R:R227	R:R:R230	22.245	4.26	No	No	6	5	6
59	R:R:D234	R:R:R230	21.3632	4.76	No	No	0	4	6
60	R:R:D234	R:R:L233	19.1076	2.71	No	No	0	4	5
61	R:R:L233	R:R:R347	17.9551	3.64	No	No	0	5	5
62	R:R:R347	R:R:R349	16.9216	4.26	No	Yes	0	5	6
63	R:R:F398	R:R:Y374	12.1601	9.28	Yes	Yes	1	7	9
64	R:R:L401	R:R:Y374	33.3552	4.69	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D114	15.33	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y115	13.24	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:C118	4.48	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y167	4.41	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y374	17.65	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F398	16.05	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L401	7.82	1	Yes	No	0	8	0	1
L:L:?1	R:R:W402	6.43	1	Yes	Yes	0	8	0	1
R:R:C87	R:R:I88	3.27	1	Yes	Yes	9	9	2	2
R:R:C87	R:R:W110	3.92	1	Yes	Yes	9	6	2	2
R:R:C87	R:R:D114	10.89	1	Yes	Yes	9	9	2	1
R:R:C87	R:R:W402	9.14	1	Yes	Yes	9	8	2	1
R:R:I88	R:R:W402	15.27	1	Yes	Yes	9	8	2	1
R:R:W110	R:R:Y91	12.54	1	Yes	Yes	6	8	2	2
R:R:F398	R:R:Y91	8.25	1	Yes	Yes	7	8	1	2
R:R:W402	R:R:Y91	6.75	1	Yes	Yes	8	8	1	2
R:R:L111	R:R:W110	6.83	0	No	Yes	7	6	2	2
R:R:D114	R:R:W110	3.35	1	Yes	Yes	9	6	1	2
R:R:F398	R:R:W110	4.01	1	Yes	Yes	7	6	1	2
R:R:L111	R:R:Y115	4.69	0	No	Yes	7	9	2	1
R:R:C118	R:R:D114	3.11	1	No	Yes	8	9	1	1
R:R:D114	R:R:W402	5.58	1	Yes	Yes	9	8	1	1
R:R:Y115	R:R:Y167	25.81	1	Yes	Yes	9	8	1	1
R:R:I171	R:R:Y115	3.63	1	Yes	Yes	7	9	2	1
R:R:T119	R:R:Y167	4.99	0	No	Yes	9	8	2	1
R:R:I171	R:R:Y167	4.84	1	Yes	Yes	7	8	2	1
R:R:Y189	R:R:Y394	13.9	0	No	Yes	4	4	2	2
R:R:F398	R:R:Y189	8.25	1	Yes	No	7	4	1	2
R:R:L401	R:R:W371	18.22	1	No	Yes	8	8	1	2
R:R:M378	R:R:Y374	4.79	0	No	Yes	8	9	2	1
R:R:Y374	R:R:Y394	5.96	1	Yes	Yes	9	4	1	2
R:R:S397	R:R:Y374	5.09	0	No	Yes	7	9	2	1
R:R:F398	R:R:Y374	9.28	1	Yes	Yes	7	9	1	1
R:R:L401	R:R:Y374	4.69	1	No	Yes	8	9	1	1
R:R:F398	R:R:W402	6.01	1	Yes	Yes	7	8	1	1
R:R:W399	R:R:W402	7.5	0	No	Yes	9	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JEQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	256
Number of Links	282
Number of Hubs	28
Number of Links mediated by Hubs	110
Number of Communities	6
Number of Nodes involved in Communities	42
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	44702
Length Of Smallest Path	3
Average Path Length	14.6346
Length of Longest Path	39
Minimum Path Strength	1.14
Average Path Strength	6.81808
Maximum Path Strength	22.19
Minimum Path Correlation	0.7
Average Path Correlation	0.932827
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	50.9897
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.416
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HSM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HSM
Name	Histamine
Synonyms	beta-aminoethylglyoxaline
Identifier
Formula	C5 H9 N3
Molecular Weight	111.145
SMILES
PubChem	774
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5N1
Sequence	>9JEQ_nogp_Chain_R A A W T A V L A A L M A L L I V A T V L G N A L V M L A F V A D S S L R T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R W T F G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R A V S Y R A Q N G D T R R A V R K M L L V W V L A F L L Y G P A I L S W E Y L S G G S S I P E G H C Y A E F F Y N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C H G H C V P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F R R A F T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F61	A	Amine	Histamine	H₃	Homo sapiens	PF-03654746	-	-	2.6	2022-10-26	doi.org/10.1038/s41467-022-33880-y
	8UH3	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-	Gi1/β1/γ1	3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8UH3 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1E	Homo sapiens	Setiptiline	-		3.31	2024-05-01	doi.org/10.1126/sciadv.adk4855
	8TH3	A	Peptide	Angiotensin	AT₁	Homo sapiens	-	AT118-H Nanobody	-	3	2024-05-22	doi.org/10.1038/s41589-024-01620-6
	8YUU	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ1	2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUU (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-	Gi1/β1/γ2	3	2024-06-05	doi.org/10.1002/advs.202310120
	8YUV (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immepip	-		3	2024-06-05	doi.org/10.1002/advs.202310120
	8YN5	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN5 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		2.7	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-	Gi1/β1/γ2	2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN6 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Imetit	-		2.77	2024-10-09	doi.org/10.1038/s41467-024-52585-y
	8YN7	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN7 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Immethridine	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-	Go/β1/γ2	2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YN8 (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Proxyfan	-		2.77	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-	Gi1/β1/γ2	2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	8YNA (No Gprot)	A	Amine	Histamine	H₄	Homo sapiens	Immepip	-		2.63	2024-10-16	doi.org/10.2210/pdb8YN7/pdb
	9JEQ	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-	Gi1/β1/γ2	3.05	2025-09-24	doi.org/10.1038/s41401-025-01633-4
	9JEQ (No Gprot)	A	Amine	Histamine	H₃	Homo sapiens	Histamine	-		3.05	2025-09-24	doi.org/10.1038/s41401-025-01633-4
	8YH3	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-	Gi1/β1/γ2	3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	8YH3 (No Gprot)	A	Nucleotide	Adenosine	A_3A	Homo sapiens	N-methyladenosine	-		3.4	2024-11-06	doi.org/10.1038/s41467-024-53473-1
	9JH3	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-	Gi1/β1/γ2	2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9JH3 (No Gprot)	A	Peptide	Apelin	Apelin; Apelin	Homo sapiens	CMF-019	-		2.93	2025-04-23	doi.org/10.1073/pnas.2423432122
	9H37	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 175670646	Na	-	1.71	2025-06-18	doi.org/10.1038/s41467-025-60629-0

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.