psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H102	3.15	Yes	Yes	1	0	6
2	L:L:?1	R:R:V105	5.47	Yes	Yes	0	0	6
3	L:L:?1	R:R:D106	14.95	Yes	No	1	0	5
4	L:L:?1	R:R:L109	10.16	Yes	No	1	0	8
5	L:L:?1	R:R:F110	21.61	Yes	Yes	0	0	7
6	L:L:?1	R:R:R201	24.53	Yes	Yes	1	0	5
7	L:L:?1	R:R:I204	7.86	Yes	No	0	0	4
8	L:L:?1	R:R:R205	15.61	Yes	Yes	1	0	5
9	L:L:?1	R:R:W254	5.57	Yes	Yes	1	0	9
10	L:L:?1	R:R:Q258	3.26	Yes	Yes	1	0	8
11	L:L:?1	R:R:F292	5.96	Yes	Yes	1	0	7
12	R:R:G21	R:R:V24	3.68	No	No	0	4	4
13	R:R:R26	R:R:T23	5.17	No	No	0	4	2
14	R:R:I27	R:R:T23	4.56	No	No	0	6	2
15	R:R:L25	R:R:P286	3.28	No	No	0	3	6
16	R:R:I27	R:R:L30	5.71	No	No	0	6	5
17	R:R:L28	R:R:P29	4.93	No	Yes	0	5	5
18	R:R:M85	R:R:P29	3.35	Yes	Yes	5	6	5
19	R:R:N285	R:R:P29	3.26	No	Yes	5	4	5
20	R:R:P29	R:R:S289	3.56	Yes	No	0	5	5
21	R:R:L30	R:R:M85	4.24	No	Yes	0	5	6
22	R:R:A86	R:R:L30	3.15	No	No	0	4	5
23	R:R:S289	R:R:V32	6.46	No	No	0	5	5
24	R:R:L33	R:R:L78	5.54	Yes	No	0	7	8
25	R:R:I82	R:R:L33	5.71	No	Yes	0	7	7
26	R:R:L33	R:R:S289	3	Yes	No	0	7	5
27	R:R:F292	R:R:L33	3.65	Yes	Yes	0	7	7
28	R:R:F293	R:R:T36	6.49	No	No	6	5	7
29	R:R:C296	R:R:T36	3.38	No	No	6	8	7
30	R:R:F37	R:R:L78	6.09	Yes	No	0	6	8
31	R:R:F37	R:R:P79	10.11	Yes	No	0	6	8
32	R:R:C296	R:R:L39	4.76	No	No	0	8	5
33	R:R:G40	R:R:T75	3.64	No	No	0	8	7
34	R:R:T75	R:R:V41	3.17	No	No	0	7	6
35	R:R:F304	R:R:G43	3.01	Yes	No	0	7	8
36	R:R:D71	R:R:N44	6.73	Yes	No	0	9	9
37	R:R:F72	R:R:N44	4.83	No	No	0	7	9
38	R:R:N44	R:R:P299	6.52	No	No	0	9	9
39	R:R:F72	R:R:G45	3.01	No	No	0	7	4
40	R:R:A68	R:R:V47	3.39	No	No	0	8	9
41	R:R:V303	R:R:V47	11.22	No	No	0	7	9
42	R:R:F304	R:R:V47	5.24	Yes	No	0	7	9
43	R:R:A68	R:R:I48	3.25	No	No	0	8	7
44	R:R:I48	R:R:L69	5.71	No	No	0	7	6
45	R:R:V50	R:R:W49	3.68	Yes	No	0	7	4
46	R:R:S316	R:R:W49	6.18	No	No	0	5	4
47	R:R:M55	R:R:V50	3.04	No	Yes	0	5	7
48	R:R:F309	R:R:V50	10.49	No	Yes	0	8	7
49	R:R:F53	R:R:G52	3.01	No	No	0	4	4
50	R:R:G52	R:R:L65	3.42	No	Yes	0	4	5
51	R:R:R312	R:R:R54	6.4	No	No	0	5	4
52	R:R:R54	R:R:S316	13.18	No	No	0	4	5
53	R:R:M55	R:R:R312	9.93	No	No	0	5	5
54	R:R:T58	R:R:T60	3.14	No	No	0	7	7
55	R:R:T58	R:R:T61	6.28	No	No	0	7	7
56	R:R:D122	R:R:V59	4.38	No	No	2	8	6
57	R:R:R137	R:R:V59	17	Yes	No	2	7	6
58	R:R:A142	R:R:V59	5.09	No	No	0	7	6
59	R:R:T60	R:R:Y64	6.24	No	Yes	0	7	8
60	R:R:R137	R:R:T60	3.88	Yes	No	0	7	7
61	R:R:I62	R:R:V139	4.61	No	No	0	7	3
62	R:R:I62	R:R:M143	4.37	No	No	0	7	4
63	R:R:C63	R:R:I119	4.91	No	Yes	0	7	9
64	R:R:C63	R:R:I146	3.27	No	No	0	7	7
65	R:R:I119	R:R:Y64	3.63	Yes	Yes	1	9	8
66	R:R:R123	R:R:Y64	5.14	Yes	Yes	1	9	8
67	R:R:V303	R:R:Y64	5.05	No	Yes	0	7	8
68	R:R:L115	R:R:N66	4.12	No	No	7	8	9
69	R:R:I146	R:R:N66	11.33	No	No	0	7	9
70	R:R:N66	R:R:W150	6.78	No	No	7	9	9
71	R:R:I116	R:R:L67	4.28	Yes	No	1	8	9
72	R:R:L67	R:R:N298	4.12	No	Yes	1	9	9
73	R:R:L67	R:R:Y302	3.52	No	Yes	1	9	9
74	R:R:D71	R:R:S112	5.89	Yes	No	0	9	9
75	R:R:D71	R:R:S295	7.36	Yes	No	0	9	9
76	R:R:D71	R:R:N298	8.08	Yes	Yes	0	9	9
77	R:R:N108	R:R:S73	10.43	No	No	0	8	7
78	R:R:F74	R:R:V105	3.93	Yes	Yes	0	7	6
79	R:R:F74	R:R:L109	15.83	Yes	No	1	7	8
80	R:R:F292	R:R:F74	9.65	Yes	Yes	1	7	7
81	R:R:F74	R:R:S295	7.93	Yes	No	0	7	9
82	R:R:I101	R:R:T77	4.56	No	No	0	5	7
83	R:R:T77	R:R:V104	3.17	No	No	0	7	5
84	R:R:T77	R:R:V105	3.17	No	Yes	0	7	6
85	R:R:F80	R:R:F93	12.86	No	Yes	0	6	7
86	R:R:F80	R:R:I101	10.05	No	No	0	6	5
87	R:R:L81	R:R:V105	4.47	No	Yes	0	6	6
88	R:R:F93	R:R:V83	3.93	Yes	No	0	7	5
89	R:R:S84	R:R:W91	4.94	No	Yes	0	5	9
90	R:R:M85	R:R:N285	8.41	Yes	No	5	6	4
91	R:R:M87	R:R:P92	8.39	No	No	0	4	3
92	R:R:D173	R:R:K90	13.83	Yes	No	3	3	4
93	R:R:K90	R:R:Y175	14.33	No	No	3	4	3
94	R:R:P92	R:R:W91	4.05	No	Yes	1	3	9
95	R:R:F93	R:R:W91	22.05	Yes	Yes	1	7	9
96	R:R:C98	R:R:W91	7.84	Yes	Yes	1	9	9
97	R:R:I101	R:R:W91	7.05	No	Yes	0	5	9
98	R:R:H102	R:R:W91	4.23	Yes	Yes	1	6	9
99	R:R:C176	R:R:W91	5.22	Yes	Yes	1	9	9
100	R:R:F93	R:R:P92	10.11	Yes	No	1	7	3
101	R:R:F93	R:R:L97	6.09	Yes	No	0	7	7
102	R:R:K99	R:R:W95	8.12	No	No	0	7	4
103	R:R:T165	R:R:W95	7.28	No	No	0	4	4
104	R:R:C98	R:R:H102	4.42	Yes	Yes	1	9	6
105	R:R:C98	R:R:L164	3.17	Yes	Yes	1	9	5
106	R:R:C98	R:R:T166	3.38	Yes	No	0	9	5
107	R:R:C176	R:R:C98	7.28	Yes	Yes	1	9	9
108	R:R:H102	R:R:L164	3.86	Yes	Yes	1	6	5
109	R:R:C176	R:R:H102	7.37	Yes	Yes	1	9	6
110	R:R:I103	R:R:T157	4.56	No	Yes	1	5	7
111	R:R:I103	R:R:V160	4.61	No	No	1	5	4
112	R:R:F161	R:R:I103	10.05	No	No	1	4	5
113	R:R:N108	R:R:V104	4.43	No	No	0	8	5
114	R:R:D106	R:R:T157	4.34	No	Yes	1	5	7
115	R:R:D106	R:R:V160	4.38	No	No	1	5	4
116	R:R:I107	R:R:T157	10.64	No	Yes	0	5	7
117	R:R:F292	R:R:L109	4.87	Yes	No	1	7	8
118	R:R:F110	R:R:F114	9.65	Yes	Yes	0	7	6
119	R:R:F110	R:R:L156	10.96	Yes	No	0	7	5
120	R:R:F110	R:R:G209	3.01	Yes	No	0	7	6
121	R:R:F114	R:R:G111	3.01	Yes	No	0	6	7
122	R:R:F114	R:R:V113	3.93	Yes	Yes	0	6	7
123	R:R:P213	R:R:V113	5.3	No	Yes	0	9	7
124	R:R:F250	R:R:V113	5.24	Yes	Yes	1	9	7
125	R:R:V113	R:R:W254	3.68	Yes	Yes	1	7	9
126	R:R:F114	R:R:L152	10.96	Yes	No	0	6	4
127	R:R:L115	R:R:P149	4.93	No	No	0	8	7
128	R:R:L115	R:R:W150	3.42	No	No	7	8	9
129	R:R:F250	R:R:I116	5.02	Yes	Yes	1	9	8
130	R:R:I116	R:R:N298	7.08	Yes	Yes	1	8	9
131	R:R:I116	R:R:Y302	6.04	Yes	Yes	1	8	9
132	R:R:F118	R:R:I146	8.79	No	No	0	7	7
133	R:R:F118	R:R:P149	4.33	No	No	0	7	7
134	R:R:I119	R:R:R123	6.26	Yes	Yes	1	9	9
135	R:R:I119	R:R:Y302	3.63	Yes	Yes	1	9	9
136	R:R:A120	R:R:Y221	5.34	No	Yes	0	9	8
137	R:R:I216	R:R:L121	4.28	No	No	0	6	7
138	R:R:C220	R:R:L121	3.17	No	No	0	7	7
139	R:R:C126	R:R:D122	4.67	No	No	2	8	8
140	R:R:D122	R:R:R137	11.91	No	Yes	2	8	7
141	R:R:R123	R:R:Y221	8.23	Yes	Yes	0	9	8
142	R:R:R123	R:R:Y302	6.17	Yes	Yes	1	9	9
143	R:R:C124	R:R:L128	3.17	Yes	No	8	8	7
144	R:R:C124	R:R:C220	7.28	Yes	No	0	8	7
145	R:R:C124	R:R:L223	3.17	Yes	No	8	8	3
146	R:R:C124	R:R:I224	3.27	Yes	No	0	8	8
147	R:R:C126	R:R:R137	6.96	No	Yes	2	8	7
148	R:R:I224	R:R:V127	7.68	No	No	0	8	8
149	R:R:K227	R:R:V127	4.55	No	No	0	5	8
150	R:R:L128	R:R:L223	4.15	No	No	8	7	3
151	R:R:H129	R:R:W132	7.41	No	No	0	6	5
152	R:R:H136	R:R:W132	25.39	No	No	0	3	5
153	R:R:H136	R:R:N135	5.1	No	No	0	3	4
154	R:R:G148	R:R:P149	4.06	No	No	0	3	7
155	R:R:L152	R:R:L156	4.15	No	No	0	4	5
156	R:R:T157	R:R:V160	3.17	Yes	No	1	7	4
157	R:R:F161	R:R:T157	5.19	No	Yes	1	4	7
158	R:R:F161	R:R:L158	4.87	No	No	0	4	4
159	R:R:M197	R:R:P159	3.35	No	No	0	1	8
160	R:R:F163	R:R:L162	8.53	No	No	0	5	5
161	R:R:F163	R:R:F180	6.43	No	Yes	0	5	6
162	R:R:F163	R:R:W183	17.04	No	No	0	5	4
163	R:R:C176	R:R:L164	4.76	Yes	Yes	1	9	5
164	R:R:F178	R:R:L164	9.74	No	Yes	0	4	5
165	R:R:N179	R:R:T165	4.39	No	No	0	3	4
166	R:R:N179	R:R:V167	5.91	No	No	0	3	1
167	R:R:T168	R:R:T174	4.71	No	No	0	2	5
168	R:R:I169	R:R:P170	3.39	No	No	0	1	3
169	R:R:D173	R:R:I169	8.4	Yes	No	3	3	1
170	R:R:I169	R:R:Y175	4.84	No	No	3	1	3
171	R:R:D173	R:R:Y175	11.49	Yes	No	3	3	3
172	R:R:F178	R:R:R201	8.55	No	Yes	0	4	5
173	R:R:A181	R:R:N179	3.13	No	No	0	5	3
174	R:R:E189	R:R:F180	3.5	Yes	Yes	0	3	6
175	R:R:F180	R:R:M197	6.22	Yes	No	0	6	1
176	R:R:S182	R:R:W183	4.94	No	No	0	7	4
177	R:R:E189	R:R:G184	6.55	Yes	No	0	3	3
178	R:R:P187	R:R:T186	5.25	No	No	0	5	6
179	R:R:E188	R:R:L191	17.23	No	No	0	3	1
180	R:R:A194	R:R:R190	4.15	No	No	0	3	5
181	R:R:I195	R:R:K269	7.27	No	No	0	1	4
182	R:R:L198	R:R:L268	5.54	No	No	0	4	3
183	R:R:R201	R:R:R205	3.2	Yes	Yes	1	5	5
184	R:R:G202	R:R:R205	4.5	No	Yes	0	4	5
185	R:R:G202	R:R:T265	5.46	No	No	0	4	4
186	R:R:I203	R:R:T265	3.04	No	No	0	4	4
187	R:R:I204	R:R:I208	4.42	No	No	0	4	5
188	R:R:Q258	R:R:R205	5.84	Yes	Yes	1	8	5
189	R:R:A261	R:R:R205	4.15	No	Yes	0	5	5
190	R:R:F206	R:R:L211	9.74	No	No	0	6	4
191	R:R:F206	R:R:Q258	3.51	No	Yes	0	6	8
192	R:R:F206	R:R:L262	18.27	No	No	0	6	5
193	R:R:I208	R:R:V207	3.07	No	No	0	5	4
194	R:R:F210	R:R:M214	11.2	No	No	0	9	6
195	R:R:F210	R:R:F255	7.5	No	Yes	0	9	6
196	R:R:F210	R:R:Q258	11.71	No	Yes	0	9	8
197	R:R:L212	R:R:P213	4.93	No	No	0	5	9
198	R:R:F250	R:R:M214	6.22	Yes	No	0	9	6
199	R:R:F251	R:R:M214	7.46	No	No	0	6	6
200	R:R:V217	R:R:Y221	3.79	No	Yes	0	8	8
201	R:R:L243	R:R:Y221	4.69	No	Yes	0	8	8
202	R:R:V246	R:R:Y221	5.05	No	Yes	0	8	8
203	R:R:V247	R:R:Y221	3.79	No	Yes	0	8	8
204	R:R:K227	R:R:K231	4.31	No	No	0	5	5
205	R:R:I228	R:R:I234	4.42	No	No	0	8	4
206	R:R:K231	R:R:M233	7.2	No	No	0	5	3
207	R:R:I234	R:R:L240	4.28	No	No	0	4	5
208	R:R:R241	R:R:S237	9.22	No	No	0	5	4
209	R:R:R238	R:R:V242	3.92	No	No	0	7	8
210	R:R:V242	R:R:V305	3.21	No	No	0	8	7
211	R:R:V246	R:R:Y302	6.31	No	Yes	0	8	9
212	R:R:L297	R:R:S249	3	No	No	0	6	7
213	R:R:L301	R:R:S249	7.51	No	No	0	8	7
214	R:R:F250	R:R:W254	10.02	Yes	Yes	1	9	9
215	R:R:F251	R:R:F255	16.08	No	Yes	0	6	6
216	R:R:C253	R:R:N294	11.02	No	No	0	8	9
217	R:R:F257	R:R:W254	3.01	Yes	Yes	1	7	9
218	R:R:Q258	R:R:W254	5.48	Yes	Yes	1	8	9
219	R:R:A291	R:R:W254	5.19	No	Yes	1	8	9
220	R:R:N294	R:R:W254	5.65	No	Yes	0	9	9
221	R:R:F255	R:R:P256	4.33	Yes	No	0	6	9
222	R:R:F255	R:R:L259	7.31	Yes	No	0	6	5
223	R:R:F257	R:R:T287	5.19	Yes	No	0	7	7
224	R:R:F257	R:R:S288	5.28	Yes	No	0	7	6
225	R:R:A291	R:R:F257	4.16	No	Yes	1	8	7
226	R:R:L283	R:R:V260	4.47	No	No	0	6	5
227	R:R:T287	R:R:V260	6.35	No	No	0	7	5
228	R:R:L263	R:R:W267	9.11	No	Yes	0	5	3
229	R:R:I280	R:R:L263	5.71	Yes	No	0	4	5
230	R:R:V266	R:R:W267	7.36	No	Yes	0	4	3
231	R:R:E270	R:R:W267	13.08	No	Yes	4	2	3
232	R:R:W267	R:R:Y277	34.73	Yes	Yes	4	3	3
233	R:R:F273	R:R:K269	4.96	Yes	No	0	5	4
234	R:R:E270	R:R:K276	4.05	No	No	4	2	1
235	R:R:E270	R:R:Y277	8.98	No	Yes	4	2	3
236	R:R:I280	R:R:M271	4.37	Yes	No	0	4	1
237	R:R:F273	R:R:L272	6.09	Yes	No	0	5	3
238	R:R:F273	R:R:Y274	4.13	Yes	No	0	5	5
239	R:R:K276	R:R:Y274	7.17	No	No	0	1	5
240	R:R:G275	R:R:K278	3.49	No	No	0	1	1
241	R:R:K276	R:R:Y277	4.78	No	Yes	4	1	3
242	R:R:I280	R:R:Y277	4.84	Yes	Yes	0	4	3
243	R:R:I279	R:R:L283	5.71	No	No	0	3	6
244	R:R:F292	R:R:S288	3.96	Yes	No	0	7	6
245	R:R:C296	R:R:F293	8.38	No	No	6	8	5
246	R:R:F293	R:R:L297	7.31	No	No	0	5	6
247	R:R:N294	R:R:N298	6.81	No	Yes	0	9	9
248	R:R:N298	R:R:Y302	5.81	Yes	Yes	1	9	9
249	R:R:F304	R:R:P299	4.33	Yes	No	0	7	9
250	R:R:F304	R:R:M300	3.73	Yes	No	0	7	7
251	R:R:L301	R:R:Y302	3.52	No	Yes	0	8	9
252	R:R:F309	R:R:V303	7.87	No	No	0	8	7
253	R:R:F304	R:R:F309	5.36	Yes	No	0	7	8
254	R:R:L313	R:R:L317	5.54	No	No	0	6	5
255	R:R:L39	R:R:V35	2.98	No	No	0	5	5
256	R:R:L313	R:R:V50	2.98	No	Yes	0	6	7
257	R:R:L141	R:R:V145	2.98	No	No	0	3	5
258	R:R:L262	R:R:V266	2.98	No	No	0	5	4
259	R:R:N285	R:R:V284	2.96	No	No	0	4	5
260	R:R:I279	R:R:I282	2.94	No	No	0	3	2
261	R:R:I228	R:R:M233	2.92	No	No	0	8	3
262	R:R:K90	R:R:M87	2.88	No	No	0	4	4
263	R:R:P239	R:R:R238	2.88	No	No	0	7	7
264	R:R:I282	R:R:L25	2.85	No	No	0	2	3
265	R:R:I48	R:R:L65	2.85	No	Yes	0	7	5
266	R:R:I195	R:R:L268	2.85	No	No	0	1	3
267	R:R:I216	R:R:L212	2.85	No	No	0	6	5
268	R:R:I224	R:R:L243	2.85	No	No	0	8	8
269	R:R:A153	R:R:F114	2.77	No	Yes	0	8	6
270	R:R:A194	R:R:F180	2.77	No	Yes	0	3	6
271	R:R:E89	R:R:M85	2.71	No	Yes	0	4	6
272	R:R:H315	R:R:I314	2.65	No	No	0	4	3
273	R:R:F37	R:R:V38	2.62	Yes	No	0	6	5
274	R:R:F37	R:R:V41	2.62	Yes	No	0	6	6
275	R:R:F72	R:R:V41	2.62	No	No	0	7	6
276	R:R:F118	R:R:V145	2.62	No	No	0	7	5
277	R:R:A70	R:R:W150	2.59	No	No	0	8	9
278	R:R:E311	R:R:Q307	2.55	No	No	0	4	5
279	R:R:I62	R:R:R57	2.51	No	No	0	7	6
280	R:R:F251	R:R:I252	2.51	No	No	0	6	6
281	R:R:M197	R:R:R201	2.48	No	Yes	0	1	5
282	R:R:F273	R:R:L191	2.44	Yes	No	0	5	1
283	R:R:L65	R:R:R57	2.43	Yes	No	0	5	6
284	R:R:I125	R:R:W132	2.35	No	No	0	5	5
285	R:R:Q307	R:R:R310	2.34	No	No	0	5	8
286	R:R:G184	R:R:G185	2.11	No	No	0	3	3
287	R:R:F96	R:R:W95	2	No	No	0	1	4
288	R:R:A120	R:R:G117	1.95	No	No	0	9	7
289	R:R:A225	R:R:G222	1.95	No	No	0	5	3
290	R:R:G148	R:R:V147	1.84	No	No	0	3	4
291	R:R:G306	R:R:V305	1.84	No	No	0	8	7
292	R:R:A133	R:R:C126	1.81	No	No	0	5	8
293	R:R:G34	R:R:I82	1.76	No	No	0	5	7
294	R:R:G148	R:R:I151	1.76	No	No	0	3	3
295	R:R:G264	R:R:I280	1.76	No	Yes	0	4	4
296	R:R:G43	R:R:L42	1.71	No	No	0	8	4
297	R:R:G43	R:R:L46	1.71	No	No	0	8	6
298	R:R:I228	R:R:P239	1.69	No	No	0	8	7
299	R:R:K227	R:R:P130	1.67	No	No	0	5	8
300	R:R:E89	R:R:G88	1.64	No	No	0	4	3
301	R:R:L290	R:R:P256	1.64	No	No	0	8	9
302	R:R:V31	R:R:V32	1.6	No	No	0	6	5
303	R:R:S140	R:R:T138	1.6	No	No	0	4	6
304	R:R:T23	R:R:V24	1.59	No	No	0	2	4
305	R:R:T177	R:R:V167	1.59	No	No	0	3	1
306	R:R:A51	R:R:L65	1.58	No	Yes	0	7	5
307	R:R:A225	R:R:L243	1.58	No	No	0	5	8
308	R:R:T166	R:R:T174	1.57	No	No	0	5	5
309	R:R:T199	R:R:T265	1.57	No	No	0	3	4
310	R:R:I219	R:R:S215	1.55	No	No	0	3	3
311	R:R:I151	R:R:V155	1.54	No	No	0	3	4
312	R:R:H129	R:R:P130	1.53	No	No	0	6	8
313	R:R:K144	R:R:S140	1.53	No	No	0	1	4
314	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
315	R:R:A181	R:R:E189	1.51	No	Yes	0	5	3
316	R:R:L100	R:R:V104	1.49	No	No	0	5	5
317	R:R:N135	R:R:V131	1.48	No	No	0	4	5
318	R:R:L141	R:R:T138	1.47	No	No	0	3	6
319	R:R:I219	R:R:L223	1.43	No	No	0	3	3
320	R:R:E189	R:R:T186	1.41	Yes	No	0	3	6
321	R:R:D173	R:R:N171	1.35	Yes	No	0	3	4
322	R:R:H229	R:R:I234	1.33	No	No	0	3	4
323	R:R:R238	R:R:S236	1.32	No	No	0	7	6
324	R:R:F180	R:R:V193	1.31	Yes	No	0	6	4
325	R:R:D308	R:R:Q307	1.31	No	No	0	6	5
326	R:R:R26	R:R:Y22	1.03	No	No	0	4	2
327	L:L:?1	R:R:A200	0.96	Yes	No	0	0	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.92417	12	1	0
2	R:R:P29	3.775	4	5	5
3	R:R:L33	4.475	4	0	7
4	R:R:F37	5.36	4	0	6
5	R:R:V50	5.0475	4	0	7
6	R:R:Y64	5.015	4	1	8
7	R:R:L65	2.57	4	0	5
8	R:R:D71	7.015	4	0	9
9	R:R:F74	9.335	4	1	7
10	R:R:M85	4.6775	4	5	6
11	R:R:W91	7.91143	7	1	9
12	R:R:F93	9.425	6	1	7
13	R:R:C98	5.218	5	1	9
14	R:R:H102	4.606	5	1	6
15	R:R:V105	4.26	4	0	6
16	R:R:F110	11.3075	4	0	7
17	R:R:V113	4.5375	4	1	7
18	R:R:F114	6.064	5	0	6
19	R:R:I116	5.605	4	1	8
20	R:R:I119	4.6075	4	1	9
21	R:R:R123	6.45	4	1	9
22	R:R:C124	4.2225	4	8	8
23	R:R:R137	9.9375	4	2	7
24	R:R:T157	5.58	5	1	7
25	R:R:L164	5.3825	4	1	5
26	R:R:D173	8.7675	4	3	3
27	R:R:C176	6.1575	4	1	9
28	R:R:F180	4.046	5	0	6
29	R:R:E189	3.2425	4	0	3
30	R:R:R201	9.69	4	1	5
31	R:R:R205	6.66	5	1	5
32	R:R:Y221	5.14833	6	0	8
33	R:R:F250	6.625	4	1	9
34	R:R:W254	5.51429	7	1	9
35	R:R:F255	8.805	4	0	6
36	R:R:F257	4.41	4	1	7
37	R:R:Q258	5.96	5	1	8
38	R:R:W267	16.07	4	4	3
39	R:R:F273	4.405	4	0	5
40	R:R:Y277	13.3325	4	4	3
41	R:R:I280	4.17	4	0	4
42	R:R:F292	5.618	5	1	7
43	R:R:N298	6.38	5	1	9
44	R:R:Y302	5	7	1	9
45	R:R:F304	4.334	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F292	35.2858	5.96	Yes	Yes	1	0	7
2	R:R:F292	R:R:L33	37.4422	3.65	Yes	Yes	0	7	7
3	R:R:L33	R:R:S289	30.284	3	Yes	No	0	7	5
4	R:R:P29	R:R:S289	25.3395	3.56	Yes	No	0	5	5
5	R:R:M85	R:R:P29	18.6034	3.35	Yes	Yes	5	6	5
6	R:R:L30	R:R:M85	13.7566	4.24	No	Yes	0	5	6
7	R:R:I27	R:R:L30	10.3512	5.71	No	No	0	6	5
8	L:L:?1	R:R:W254	100	5.57	Yes	Yes	1	0	9
9	R:R:F257	R:R:W254	12.1457	3.01	Yes	Yes	1	7	9
10	R:R:F257	R:R:T287	10.5895	5.19	Yes	No	0	7	7
11	R:R:F250	R:R:W254	67.4448	10.02	Yes	Yes	1	9	9
12	R:R:F250	R:R:I116	78.0257	5.02	Yes	Yes	1	9	8
13	R:R:I116	R:R:Y302	76.5699	6.04	Yes	Yes	1	8	9
14	R:R:L301	R:R:Y302	13.3431	3.52	No	Yes	0	8	9
15	R:R:L301	R:R:S249	11.6949	7.51	No	No	0	8	7
16	R:R:L297	R:R:S249	10.0411	3	No	No	0	6	7
17	R:R:N294	R:R:W254	78.9043	5.65	No	Yes	0	9	9
18	R:R:N294	R:R:N298	79.0536	6.81	No	Yes	0	9	9
19	R:R:N298	R:R:Y302	82.1489	5.81	Yes	Yes	1	9	9
20	L:L:?1	R:R:V105	17.3343	5.47	Yes	Yes	0	0	6
21	R:R:F74	R:R:V105	14.0925	3.93	Yes	Yes	0	7	6
22	R:R:F74	R:R:S295	37.3417	7.93	Yes	No	0	7	9
23	R:R:D71	R:R:S295	36.6296	7.36	Yes	No	0	9	9
24	R:R:D71	R:R:N44	39.9173	6.73	Yes	No	0	9	9
25	R:R:N44	R:R:P299	35.7883	6.52	No	No	0	9	9
26	R:R:F304	R:R:P299	34.6312	4.33	Yes	No	0	7	9
27	R:R:F292	R:R:F74	17.9344	9.65	Yes	Yes	1	7	7
28	R:R:D71	R:R:N298	29.1039	8.08	Yes	Yes	0	9	9
29	R:R:F304	R:R:V47	17.0213	5.24	Yes	No	0	7	9
30	R:R:A68	R:R:V47	34.1718	3.39	No	No	0	8	9
31	R:R:I119	R:R:Y302	51.2476	3.63	Yes	Yes	1	9	9
32	R:R:I119	R:R:Y64	32.8682	3.63	Yes	Yes	1	9	8
33	R:R:V303	R:R:Y64	45.7748	5.05	No	Yes	0	7	8
34	R:R:V303	R:R:V47	24.0848	11.22	No	No	0	7	9
35	R:R:R123	R:R:Y302	66.5001	6.17	Yes	Yes	1	9	9
36	R:R:R123	R:R:Y64	35.6218	5.14	Yes	Yes	1	9	8
37	R:R:A68	R:R:I48	31.0937	3.25	No	No	0	8	7
38	R:R:F304	R:R:F309	14.5376	5.36	Yes	No	0	7	8
39	R:R:F309	R:R:V50	28.0616	10.49	No	Yes	0	8	7
40	R:R:F309	R:R:V303	20.4238	7.87	No	No	0	8	7
41	R:R:I48	R:R:L65	24.9203	2.85	No	Yes	0	7	5
42	R:R:T60	R:R:Y64	23.5105	6.24	No	Yes	0	7	8
43	R:R:R137	R:R:T60	15.6344	3.88	Yes	No	0	7	7
44	R:R:L65	R:R:R57	12.5047	2.43	Yes	No	0	5	6
45	R:R:C63	R:R:I119	23.6828	4.91	No	Yes	0	7	9
46	R:R:C63	R:R:I146	22.4625	3.27	No	No	0	7	7
47	R:R:T77	R:R:V105	13.5355	3.17	No	Yes	0	7	6
48	L:L:?1	R:R:H102	42.981	3.15	Yes	Yes	1	0	6
49	R:R:H102	R:R:W91	31.2602	4.23	Yes	Yes	1	6	9
50	R:R:P92	R:R:W91	19.1489	4.05	No	Yes	1	3	9
51	R:R:M87	R:R:P92	17.3831	8.39	No	No	0	4	3
52	R:R:K90	R:R:M87	15.4794	2.88	No	No	0	4	4
53	L:L:?1	R:R:R201	43.3572	24.53	Yes	Yes	1	0	5
54	R:R:M197	R:R:R201	43.9056	2.48	No	Yes	0	1	5
55	R:R:F180	R:R:M197	40.2561	6.22	Yes	No	0	6	1
56	R:R:E189	R:R:F180	25.2965	3.5	Yes	Yes	0	3	6
57	R:R:A181	R:R:E189	15.7521	1.51	No	Yes	0	5	3
58	R:R:A181	R:R:N179	13.8054	3.13	No	No	0	5	3
59	L:L:?1	R:R:D106	14.3796	14.95	Yes	No	1	0	5
60	R:R:F118	R:R:I146	15.5253	8.79	No	No	0	7	7
61	R:R:R123	R:R:Y221	41.8612	8.23	Yes	Yes	0	9	8
62	R:R:V246	R:R:Y302	36.308	6.31	No	Yes	0	8	9
63	R:R:V246	R:R:Y221	35.1423	5.05	No	Yes	0	8	8
64	R:R:L243	R:R:Y221	65.0587	4.69	No	Yes	0	8	8
65	R:R:I224	R:R:L243	57.9636	2.85	No	No	0	8	8
66	R:R:I224	R:R:V127	53.694	7.68	No	No	0	8	8
67	R:R:K227	R:R:V127	51.3108	4.55	No	No	0	5	8
68	R:R:K227	R:R:P130	18.2215	1.67	No	No	0	5	8
69	R:R:H129	R:R:P130	15.6402	1.53	No	No	0	6	8
70	R:R:H129	R:R:W132	13.0473	7.41	No	No	0	6	5
71	L:L:?1	R:R:Q258	14.9568	3.26	Yes	Yes	1	0	8
72	R:R:F206	R:R:Q258	51.9109	3.51	No	Yes	0	6	8
73	R:R:F206	R:R:L262	49.0166	18.27	No	No	0	6	5
74	R:R:L262	R:R:V266	47.5608	2.98	No	No	0	5	4
75	R:R:V266	R:R:W267	46.0993	7.36	No	Yes	0	4	3
76	R:R:E270	R:R:W267	16.9093	13.08	No	Yes	4	2	3
77	R:R:E270	R:R:K276	15.3817	4.05	No	No	4	2	1
78	R:R:K276	R:R:Y274	27.7773	7.17	No	No	0	1	5
79	R:R:F273	R:R:Y274	24.6676	4.13	Yes	No	0	5	5
80	R:R:W267	R:R:Y277	21.5695	34.73	Yes	Yes	4	3	3
81	R:R:K276	R:R:Y277	15.4966	4.78	No	Yes	4	1	3
82	R:R:F273	R:R:K269	12.3755	4.96	Yes	No	0	5	4
83	R:R:G202	R:R:R205	11.5858	4.5	No	Yes	0	4	5
84	R:R:K227	R:R:K231	31.0535	4.31	No	No	0	5	5
85	R:R:K231	R:R:M233	28.4951	7.2	No	No	0	5	3
86	R:R:I228	R:R:M233	25.931	2.92	No	No	0	8	3
87	R:R:I228	R:R:P239	15.6143	1.69	No	No	0	8	7
88	R:R:P239	R:R:R238	13.0215	2.88	No	No	0	7	7
89	R:R:Q258	R:R:R205	10.3827	5.84	Yes	Yes	1	8	5
90	R:R:Q258	R:R:W254	44.4626	5.48	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H102	3.15	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:V105	5.47	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:D106	14.95	1	Yes	No	0	5	0	1
L:L:?1	R:R:L109	10.16	1	Yes	No	0	8	0	1
L:L:?1	R:R:F110	21.61	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R201	24.53	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I204	7.86	1	Yes	No	0	4	0	1
L:L:?1	R:R:R205	15.61	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W254	5.57	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Q258	3.26	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F292	5.96	1	Yes	Yes	0	7	0	1
R:R:F292	R:R:L33	3.65	1	Yes	Yes	7	7	1	2
R:R:F74	R:R:V105	3.93	1	Yes	Yes	7	6	2	1
R:R:F74	R:R:L109	15.83	1	Yes	No	7	8	2	1
R:R:F292	R:R:F74	9.65	1	Yes	Yes	7	7	1	2
R:R:T77	R:R:V105	3.17	0	No	Yes	7	6	2	1
R:R:L81	R:R:V105	4.47	0	No	Yes	6	6	2	1
R:R:C98	R:R:W91	7.84	1	Yes	Yes	9	9	2	2
R:R:H102	R:R:W91	4.23	1	Yes	Yes	6	9	1	2
R:R:C176	R:R:W91	5.22	1	Yes	Yes	9	9	2	2
R:R:C98	R:R:H102	4.42	1	Yes	Yes	9	6	2	1
R:R:C98	R:R:L164	3.17	1	Yes	Yes	9	5	2	2
R:R:C176	R:R:C98	7.28	1	Yes	Yes	9	9	2	2
R:R:H102	R:R:L164	3.86	1	Yes	Yes	6	5	1	2
R:R:C176	R:R:H102	7.37	1	Yes	Yes	9	6	2	1
R:R:D106	R:R:T157	4.34	1	No	Yes	5	7	1	2
R:R:D106	R:R:V160	4.38	1	No	No	5	4	1	2
R:R:F292	R:R:L109	4.87	1	Yes	No	7	8	1	1
R:R:F110	R:R:F114	9.65	0	Yes	Yes	7	6	1	2
R:R:F110	R:R:L156	10.96	0	Yes	No	7	5	1	2
R:R:F110	R:R:G209	3.01	0	Yes	No	7	6	1	2
R:R:F114	R:R:V113	3.93	0	Yes	Yes	6	7	2	2
R:R:F250	R:R:V113	5.24	1	Yes	Yes	9	7	2	2
R:R:V113	R:R:W254	3.68	1	Yes	Yes	7	9	2	1
R:R:T157	R:R:V160	3.17	1	Yes	No	7	4	2	2
R:R:C176	R:R:L164	4.76	1	Yes	Yes	9	5	2	2
R:R:F178	R:R:L164	9.74	0	No	Yes	4	5	2	2
R:R:F178	R:R:R201	8.55	0	No	Yes	4	5	2	1
R:R:R201	R:R:R205	3.2	1	Yes	Yes	5	5	1	1
R:R:G202	R:R:R205	4.5	0	No	Yes	4	5	2	1
R:R:I204	R:R:I208	4.42	0	No	No	4	5	1	2
R:R:Q258	R:R:R205	5.84	1	Yes	Yes	8	5	1	1
R:R:A261	R:R:R205	4.15	0	No	Yes	5	5	2	1
R:R:F206	R:R:Q258	3.51	0	No	Yes	6	8	2	1
R:R:F210	R:R:Q258	11.71	0	No	Yes	9	8	2	1
R:R:F250	R:R:W254	10.02	1	Yes	Yes	9	9	2	1
R:R:F257	R:R:W254	3.01	1	Yes	Yes	7	9	2	1
R:R:Q258	R:R:W254	5.48	1	Yes	Yes	8	9	1	1
R:R:A291	R:R:W254	5.19	1	No	Yes	8	9	2	1
R:R:N294	R:R:W254	5.65	0	No	Yes	9	9	2	1
R:R:F257	R:R:S288	5.28	1	Yes	No	7	6	2	2
R:R:A291	R:R:F257	4.16	1	No	Yes	8	7	2	2
R:R:F292	R:R:S288	3.96	1	Yes	No	7	6	1	2
R:R:M197	R:R:R201	2.48	0	No	Yes	1	5	2	1
L:L:?1	R:R:A200	0.96	1	Yes	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZBW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	282
Number of Links	327
Number of Hubs	45
Number of Links mediated by Hubs	166
Number of Communities	8
Number of Nodes involved in Communities	55
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	97950
Length Of Smallest Path	3
Average Path Length	13.9946
Length of Longest Path	31
Minimum Path Strength	1.46
Average Path Strength	6.1512
Maximum Path Strength	23.07
Minimum Path Correlation	0.7
Average Path Correlation	0.927915
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	47.4202
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.2597
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • amyloid-beta binding • binding • peptide binding • G protein-coupled receptor activity • transmembrane signaling receptor activity • complement receptor activity • immune receptor activity • cargo receptor activity • RAGE receptor binding • protein binding • signaling receptor binding • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • regulation of cellular process • reactive oxygen species metabolic process • positive regulation of biological process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • cellular process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • positive regulation of cellular process • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • immune system process • regulation of immune response • activation of immune response • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • defense response • negative regulation of response to stimulus • negative regulation of biological process • response to external stimulus • regulation of inflammatory response • response to stress • negative regulation of response to external stimulus • regulation of response to stress • negative regulation of defense response • inflammatory response • positive chemotaxis • chemotaxis • taxis • response to chemical • locomotion • regulation of localization • import into cell • positive regulation of cellular component organization • regulation of cellular component organization • transport • vesicle-mediated transport • cellular component organization • localization • positive regulation of endocytosis • phagocytosis • cellular component organization or biogenesis • regulation of endocytosis • regulation of transport • regulation of phagocytosis • regulation of vesicle-mediated transport • establishment of localization • positive regulation of phagocytosis • positive regulation of transport • endocytosis • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • calcium-mediated signaling • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • neuron apoptotic process • negative regulation of neuron apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of neuron apoptotic process • developmental process • anatomical structure morphogenesis • odontogenesis of dentin-containing tooth • dentinogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • odontogenesis • animal organ development • animal organ morphogenesis • multicellular organismal process • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • system development • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • neuroinflammatory response • positive regulation of monocyte chemotaxis • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • regulation of monocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell migration • cell motility • regulation of mononuclear cell migration • cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • monocyte chemotaxis • leukocyte migration • cellular response to chemical stimulus • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell adhesion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of response to biotic stimulus • regulation of response to biotic stimulus • innate immune response • positive regulation of innate immune response • regulation of innate immune response • defense response to symbiont • defense response to other organism • positive regulation of defense response • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • response to amyloid-beta • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • receptor-mediated endocytosis • membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • tertiary granule membrane • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • tertiary granule • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule membrane • specific granule • cell periphery • plasma membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to nutrient levels • response to nutrient • midbody • dense core granule • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25090
Sequence	>8ZBW_nogp_Chain_R S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T R T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G E K W P F G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H P V W A Q N H R T V S L A M K V I V G P W I L A L V L T L P V F L F L T T V T I P N G D T Y C T F N F A S W G G T P E E R L K V A I T M L T A R G I I R F V I G F L P M S I V A I C Y G L I A A K I H K K G M I K S S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W L K E M L F Y G K Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D F R E R L I H S L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6OMM	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-	Gi1/β1/γ2	3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6OMM (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVX	-		3.17	2020-02-26	doi.org/10.1038/s41467-020-14728-9
	6LW5	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	WKYMVm	-	-	2.8	2020-03-25	doi.org/10.1038/s41467-020-15009-1
	7T6S	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	TC-FPR 43	-	Gi1/β1/γ2	3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6S (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	TC-FPR 43	-		3	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-	Gi1/β1/γ2	2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6U (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	CGEN-855A	-		2.9	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6V (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		3.1	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVV	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-	Gi2/β1/γ2	2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVV (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMLFII	-		2.9	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-	Gi2/β1/γ2	3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	fMYFINILTL	-		3.1	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-	Gi2/β1/γ2	2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVX (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Humanin	-		2.8	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-	Gi2/β1/γ2	3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVY (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Amyloid-β42	-		3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	8Y62	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y62 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C16:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-02-05	doi.org/10.1126/science.ado4188
	8Y63 (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C20:0 Ceramide	-		3.2	2025-02-05	doi.org/10.1126/science.ado4188
	9JHJ	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-	Gi1/β1/γ2	3.2	2025-03-19	doi.org/10.1126/science.ado4188
	9JHJ (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	C18:0 Ceramide	-		3.2	2025-03-19	doi.org/10.1126/science.ado4188
	8ZBW	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Quin-C1	-	Gi2/β1/γ2	2.58	2025-09-10	doi.org/10.1038/s41401-025-01525-7
	8ZBW (No Gprot)	A	Peptide	Formylpeptide	FPR2-ALX	Homo sapiens	Quin-C1	-		2.58	2025-09-10	doi.org/10.1038/s41401-025-01525-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZBW_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.