psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C274	R:R:C28	7.28	No	No	0	5	9
2	R:R:E31	R:R:F29	4.66	No	No	0	5	4
3	R:R:H281	R:R:R30	28.21	No	No	0	4	5
4	R:R:E32	W:W:?1	5.01	No	Yes	0	4	0
5	R:R:N33	R:R:N35	10.9	No	No	0	6	3
6	R:R:N33	R:R:N37	12.26	No	No	0	6	3
7	R:R:A34	R:R:K38	8.03	No	No	0	1	4
8	R:R:F36	R:R:F40	18.22	No	No	0	4	5
9	R:R:L41	R:R:N37	5.49	No	No	0	6	3
10	R:R:F40	R:R:I44	6.28	No	No	0	5	5
11	R:R:F40	R:R:I286	6.28	No	No	0	5	6
12	R:R:L41	R:R:Y45	10.55	No	Yes	0	6	7
13	R:R:L41	R:R:S285	4.5	No	No	0	6	5
14	R:R:P42	R:R:V99	5.3	No	No	0	5	4
15	R:R:L91	R:R:Y45	4.69	Yes	Yes	1	8	7
16	R:R:W94	R:R:Y45	9.65	Yes	Yes	1	7	7
17	R:R:F292	R:R:Y45	4.13	Yes	Yes	1	7	7
18	R:R:F293	R:R:I48	12.56	No	No	0	5	7
19	R:R:F49	R:R:L50	4.87	No	No	0	6	5
20	R:R:F49	R:R:I53	6.28	No	Yes	0	6	5
21	R:R:F49	R:R:P92	10.11	No	No	0	6	9
22	R:R:G52	R:R:V88	3.68	No	No	0	8	6
23	R:R:I53	R:R:L85	7.14	Yes	No	4	5	7
24	R:R:I53	R:R:V88	6.14	Yes	No	0	5	6
25	R:R:I53	R:R:I89	5.89	Yes	No	4	5	4
26	R:R:G55	R:R:P299	4.06	No	No	0	8	9
27	R:R:N56	R:R:S81	8.94	No	No	0	9	9
28	R:R:D84	R:R:N56	5.39	Yes	No	0	9	9
29	R:R:N56	R:R:P299	11.4	No	No	0	9	9
30	R:R:S81	R:R:V59	9.7	No	No	0	9	8
31	R:R:I60	R:R:L85	4.28	No	No	0	7	7
32	R:R:M63	R:R:R70	4.96	No	No	0	6	6
33	R:R:D74	R:R:M63	5.54	No	No	5	8	6
34	R:R:M63	R:R:Y302	4.79	No	Yes	5	6	9
35	R:R:G64	R:R:Y65	4.35	No	No	0	2	5
36	R:R:K67	R:R:R70	3.71	No	No	0	6	6
37	R:R:L78	R:R:R70	3.64	No	No	0	5	6
38	R:R:D74	R:R:S71	8.83	No	No	0	8	7
39	R:R:K75	R:R:M72	8.64	No	Yes	0	6	6
40	R:R:D133	R:R:M72	8.32	No	Yes	0	8	6
41	R:R:A152	R:R:M72	4.83	No	Yes	0	3	6
42	R:R:D74	R:R:Y302	9.2	No	Yes	5	8	9
43	R:R:F129	R:R:Y76	9.28	Yes	Yes	0	5	7
44	R:R:I130	R:R:Y76	4.84	No	Yes	0	8	7
45	R:R:A152	R:R:Y76	4	No	Yes	0	3	7
46	R:R:V156	R:R:Y76	3.79	No	Yes	0	5	7
47	R:R:N298	R:R:R77	13.26	Yes	No	0	9	8
48	R:R:R77	R:R:Y302	31.9	No	Yes	0	8	9
49	R:R:H79	R:R:V156	9.69	Yes	No	6	9	5
50	R:R:H79	R:R:Y157	6.53	Yes	No	6	9	7
51	R:R:H79	R:R:W161	6.35	Yes	Yes	0	9	9
52	R:R:L80	R:R:N298	8.24	No	Yes	0	9	9
53	R:R:N298	R:R:S81	7.45	Yes	No	0	9	9
54	R:R:D84	R:R:N119	6.73	Yes	No	1	9	8
55	R:R:D84	R:R:H294	7.56	Yes	Yes	1	9	9
56	R:R:C295	R:R:D84	10.89	No	Yes	1	9	9
57	R:R:I89	R:R:L85	4.28	No	No	4	4	7
58	R:R:I115	R:R:L86	8.56	No	No	0	5	7
59	R:R:F87	R:R:L91	4.87	Yes	Yes	1	7	8
60	R:R:F87	R:R:W94	4.01	Yes	Yes	1	7	7
61	R:R:F87	R:R:N119	12.08	Yes	No	1	7	8
62	R:R:F292	R:R:F87	12.86	Yes	Yes	1	7	7
63	R:R:I115	R:R:T90	6.08	No	No	0	5	6
64	R:R:L91	R:R:W94	4.56	Yes	Yes	1	8	7
65	R:R:F104	R:R:F93	18.22	Yes	No	1	7	6
66	R:R:F93	R:R:V112	5.24	No	No	0	6	5
67	R:R:W94	R:R:Y116	5.79	Yes	Yes	1	7	6
68	R:R:E288	R:R:W94	5.45	Yes	Yes	1	5	7
69	R:R:F292	R:R:W94	6.01	Yes	Yes	1	7	7
70	R:R:W94	W:W:?1	16.35	Yes	Yes	1	7	0
71	R:R:F104	R:R:V96	6.55	Yes	No	0	7	5
72	R:R:D97	R:R:W102	5.58	No	Yes	0	5	9
73	R:R:D97	W:W:?1	19.49	No	Yes	0	5	0
74	R:R:A100	R:R:Y103	4	No	No	0	5	3
75	R:R:N101	R:R:Y103	9.3	No	No	0	4	3
76	R:R:N101	R:R:R183	4.82	No	No	0	4	3
77	R:R:N101	R:R:Y184	5.81	No	No	0	4	5
78	R:R:F104	R:R:W102	16.04	Yes	Yes	1	7	9
79	R:R:C109	R:R:W102	3.92	No	Yes	1	9	9
80	R:R:V112	R:R:W102	4.9	No	Yes	0	5	9
81	R:R:V177	R:R:W102	4.9	No	Yes	0	4	9
82	R:R:C186	R:R:W102	16.98	No	Yes	1	9	9
83	R:R:N106	R:R:N176	5.45	No	No	0	3	4
84	R:R:N106	R:R:V177	7.39	No	No	0	3	4
85	R:R:C109	R:R:C186	7.28	No	No	1	9	9
86	R:R:K110	R:R:N176	5.6	No	No	0	7	4
87	R:R:D171	R:R:H113	7.56	No	Yes	1	4	6
88	R:R:A175	R:R:H113	5.85	No	Yes	0	4	6
89	R:R:H113	R:R:R188	11.28	Yes	No	1	6	5
90	R:R:H113	W:W:?1	3.89	Yes	Yes	1	6	0
91	R:R:T168	R:R:V114	11.11	No	No	0	6	5
92	R:R:L120	R:R:Y116	11.72	No	Yes	0	7	6
93	R:R:E288	R:R:Y116	5.61	Yes	Yes	1	5	6
94	R:R:Y116	W:W:?1	12.4	Yes	Yes	1	6	0
95	R:R:T117	R:R:Y121	7.49	Yes	Yes	1	5	7
96	R:R:D171	R:R:T117	8.67	No	Yes	1	4	5
97	R:R:H203	R:R:T117	4.11	No	Yes	1	4	5
98	R:R:H294	R:R:N119	3.83	Yes	No	1	9	8
99	R:R:L120	R:R:W252	5.69	No	Yes	0	7	9
100	R:R:L167	R:R:Y121	5.86	No	Yes	0	5	7
101	R:R:H203	R:R:Y121	10.89	No	Yes	1	4	7
102	R:R:V206	R:R:Y121	11.36	No	Yes	0	4	7
103	R:R:S122	R:R:W161	6.18	No	Yes	0	7	9
104	R:R:F248	R:R:S123	3.96	Yes	No	0	9	9
105	R:R:V124	R:R:W125	3.68	No	No	1	7	5
106	R:R:P211	R:R:V124	10.6	No	No	1	9	7
107	R:R:F248	R:R:V124	5.24	Yes	No	1	9	7
108	R:R:A128	R:R:W125	3.89	No	No	0	7	5
109	R:R:P211	R:R:W125	16.21	No	No	1	9	5
110	R:R:I245	R:R:L127	4.28	No	No	0	7	8
111	R:R:F248	R:R:L127	8.53	Yes	No	0	9	8
112	R:R:F129	R:R:L151	7.31	Yes	No	0	5	4
113	R:R:F129	R:R:V155	3.93	Yes	No	0	5	2
114	R:R:F129	R:R:V160	5.24	Yes	No	0	5	7
115	R:R:I215	R:R:S131	7.74	No	No	0	7	9
116	R:R:C218	R:R:S131	6.89	No	No	0	6	9
117	R:R:S131	R:R:Y219	5.09	No	Yes	0	9	8
118	R:R:L132	R:R:V214	4.47	No	No	0	6	6
119	R:R:C218	R:R:L132	4.76	No	No	0	6	6
120	R:R:D133	R:R:R148	14.29	No	Yes	0	8	6
121	R:R:A137	R:R:R134	4.15	No	Yes	0	8	9
122	R:R:A237	R:R:R134	5.53	No	Yes	0	7	9
123	R:R:L238	R:R:R134	4.86	No	Yes	0	5	9
124	R:R:R134	R:R:T241	7.76	Yes	No	0	9	7
125	R:R:L136	R:R:Y135	4.69	No	Yes	0	5	8
126	R:R:V139	R:R:Y135	7.57	No	Yes	7	7	8
127	R:R:H140	R:R:Y135	9.8	No	Yes	7	6	8
128	R:R:I221	R:R:Y135	7.25	No	Yes	0	4	8
129	R:R:L136	R:R:R148	4.86	No	Yes	0	5	6
130	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
131	R:R:I138	R:R:I222	5.89	Yes	No	0	8	8
132	R:R:I138	R:R:L238	4.28	Yes	No	0	8	5
133	R:R:H140	R:R:V139	5.54	No	No	7	6	7
134	R:R:N143	R:R:T142	7.31	No	No	0	5	5
135	R:R:R148	R:R:S144	6.59	Yes	No	0	6	5
136	R:R:P147	R:R:R146	4.32	No	No	0	4	5
137	R:R:E153	R:R:K149	12.15	No	No	0	7	6
138	R:R:V156	R:R:Y157	5.05	No	No	6	5	7
139	R:R:G159	R:R:P163	4.06	No	No	0	3	4
140	R:R:F199	R:R:P170	7.22	No	No	0	5	8
141	R:R:D171	R:R:R188	8.34	No	No	1	4	5
142	R:R:F174	R:R:I173	8.79	No	No	0	4	3
143	R:R:F174	R:R:Y190	15.47	No	Yes	1	4	4
144	R:R:F174	R:R:W195	8.02	No	Yes	1	4	5
145	R:R:V177	R:R:Y184	3.79	No	No	0	4	5
146	R:R:F189	R:R:S178	6.61	No	No	0	3	1
147	R:R:E179	R:R:Y184	4.49	No	No	0	2	5
148	R:R:I185	R:R:R183	6.26	No	No	0	3	3
149	R:R:R183	W:W:?1	6.43	No	Yes	0	3	0
150	R:R:C186	W:W:?1	4.8	No	Yes	1	9	0
151	R:R:D187	R:R:F189	4.78	No	No	0	3	3
152	R:R:D187	W:W:?1	7.18	No	Yes	0	3	0
153	R:R:R188	R:R:Y190	8.23	No	Yes	1	5	4
154	R:R:W195	R:R:Y190	10.61	Yes	Yes	1	5	4
155	R:R:F199	R:R:Y190	12.38	No	Yes	1	5	4
156	R:R:P191	R:R:W195	13.51	No	Yes	0	5	5
157	R:R:L194	R:R:N192	8.24	Yes	No	0	2	1
158	R:R:N192	R:R:W195	5.65	No	Yes	0	1	5
159	R:R:N192	S:S:E268	7.89	No	No	0	1	2
160	R:R:D193	R:R:L194	5.43	No	Yes	0	1	2
161	R:R:D193	S:S:L194	5.43	No	Yes	0	1	2
162	R:R:L194	S:S:D193	9.5	Yes	No	0	2	1
163	R:R:L194	S:S:V197	7.45	Yes	No	0	2	3
164	R:R:F199	R:R:W195	6.01	No	Yes	1	5	5
165	R:R:W195	S:S:L267	17.08	Yes	No	0	5	1
166	R:R:V197	S:S:L194	7.45	No	Yes	0	3	2
167	R:R:I259	R:R:Q200	4.12	Yes	No	0	5	5
168	R:R:F201	S:S:F201	7.5	No	No	0	4	4
169	R:R:M205	S:S:M205	4.33	No	Yes	0	4	4
170	R:R:L208	R:R:Y256	16.41	No	No	0	8	8
171	R:R:L210	S:S:L210	6.92	No	No	0	6	6
172	R:R:I222	R:R:Y219	3.63	No	Yes	0	8	8
173	R:R:T241	R:R:Y219	4.99	No	Yes	0	7	8
174	R:R:V242	R:R:Y219	5.05	No	Yes	0	4	8
175	R:R:I245	R:R:Y219	3.63	No	Yes	0	7	8
176	R:R:K225	R:R:S224	4.59	No	No	0	4	4
177	R:R:H232	R:R:K230	3.93	No	No	0	4	5
178	R:R:I243	R:R:L301	4.28	No	No	0	5	7
179	R:R:F248	R:R:F249	8.57	Yes	No	0	9	4
180	R:R:F248	R:R:W252	9.02	Yes	Yes	1	9	9
181	R:R:F248	R:R:H294	7.92	Yes	Yes	1	9	9
182	R:R:C251	R:R:L297	4.76	No	No	0	8	6
183	R:R:W252	R:R:Y255	6.75	Yes	Yes	0	9	7
184	R:R:W252	R:R:Y256	10.61	Yes	No	0	9	8
185	R:R:A291	R:R:W252	9.08	No	Yes	0	8	9
186	R:R:H294	R:R:W252	13.75	Yes	Yes	1	9	9
187	R:R:I257	R:R:L253	4.28	No	No	0	6	5
188	R:R:I259	R:R:Y255	13.3	Yes	Yes	0	5	7
189	R:R:T287	R:R:Y255	4.99	No	Yes	0	6	7
190	R:R:E288	R:R:Y255	5.61	Yes	Yes	0	5	7
191	R:R:I261	R:R:V280	6.14	No	No	0	5	5
192	R:R:D262	R:R:V280	4.38	No	No	0	5	5
193	R:R:D262	R:R:I284	5.6	No	No	0	5	4
194	R:R:F264	R:R:I269	12.56	No	No	0	4	1
195	R:R:F264	R:R:I270	3.77	No	No	0	4	5
196	R:R:F276	R:R:I265	3.77	No	No	0	1	3
197	R:R:E277	R:R:I265	9.56	No	No	0	2	3
198	R:R:L266	S:S:L194	4.15	No	Yes	0	3	2
199	R:R:L267	S:S:W195	19.36	No	Yes	0	1	5
200	R:R:E268	R:R:K271	10.8	No	No	0	2	3
201	R:R:E268	S:S:N192	11.83	No	No	0	2	1
202	R:R:F276	R:R:Q272	17.57	No	No	0	1	2
203	R:R:F276	R:R:V280	3.93	No	No	0	1	5
204	R:R:K282	R:R:W283	4.64	No	No	0	2	6
205	R:R:E288	R:R:F292	8.16	Yes	Yes	1	5	7
206	R:R:E288	W:W:?1	11.02	Yes	Yes	1	5	0
207	R:R:C295	R:R:H294	8.85	No	Yes	1	9	9
208	R:R:N298	R:R:P299	4.89	Yes	No	0	9	9
209	R:R:A303	R:R:F304	4.16	No	No	0	7	6
210	R:R:F304	R:R:F309	9.65	No	No	0	6	8
211	R:R:H315	R:R:S312	6.97	No	No	0	4	6
212	S:S:C274	S:S:C28	7.28	No	No	0	5	9
213	S:S:N33	S:S:N35	8.17	No	No	0	6	3
214	S:S:A34	S:S:K38	4.82	No	No	0	1	4
215	S:S:F36	S:S:F40	16.08	No	No	0	4	5
216	S:S:L41	S:S:N37	6.87	No	No	0	6	3
217	S:S:K282	S:S:N37	4.2	No	No	0	2	3
218	S:S:F40	S:S:I44	10.05	No	No	0	5	5
219	S:S:F40	S:S:I286	7.54	No	No	0	5	6
220	S:S:L41	S:S:Y45	8.21	No	Yes	0	6	7
221	S:S:P42	S:S:V99	5.3	No	No	0	5	4
222	S:S:W94	S:S:Y45	9.65	Yes	Yes	2	7	7
223	S:S:F292	S:S:Y45	4.13	Yes	Yes	2	7	7
224	S:S:F49	S:S:I53	3.77	No	No	0	6	5
225	S:S:F49	S:S:P92	10.11	No	No	0	6	9
226	S:S:G52	S:S:V88	3.68	No	No	0	8	6
227	S:S:I53	S:S:V54	4.61	No	No	0	5	4
228	S:S:G55	S:S:P299	4.06	No	No	0	8	9
229	S:S:N56	S:S:S81	8.94	No	No	0	9	9
230	S:S:D84	S:S:N56	5.39	Yes	No	0	9	9
231	S:S:N56	S:S:P299	9.77	No	No	0	9	9
232	S:S:S81	S:S:V59	8.08	No	No	0	9	8
233	S:S:V59	S:S:Y302	5.05	No	Yes	0	8	9
234	S:S:I60	S:S:L85	4.28	No	No	0	7	7
235	S:S:M63	S:S:R70	6.2	Yes	No	9	6	6
236	S:S:D74	S:S:M63	5.54	No	Yes	0	8	6
237	S:S:L78	S:S:M63	4.24	No	Yes	9	5	6
238	S:S:K75	S:S:R70	4.95	No	No	0	6	6
239	S:S:L78	S:S:R70	4.86	No	No	9	5	6
240	S:S:D74	S:S:S71	7.36	No	No	0	8	7
241	S:S:K75	S:S:M72	7.2	No	Yes	0	6	6
242	S:S:D133	S:S:M72	9.7	No	Yes	10	8	6
243	S:S:M72	S:S:R148	4.96	Yes	Yes	10	6	6
244	S:S:A152	S:S:M72	4.83	No	Yes	0	3	6
245	S:S:D74	S:S:Y302	8.05	No	Yes	0	8	9
246	S:S:E153	S:S:K75	6.75	No	No	0	7	6
247	S:S:F129	S:S:Y76	8.25	Yes	No	0	5	7
248	S:S:I130	S:S:Y76	4.84	No	No	0	8	7
249	S:S:A152	S:S:Y76	5.34	No	No	0	3	7
250	S:S:N298	S:S:R77	13.26	Yes	No	8	9	8
251	S:S:R77	S:S:Y302	32.92	No	Yes	8	8	9
252	S:S:H79	S:S:I126	3.98	Yes	No	0	9	7
253	S:S:H79	S:S:V156	9.69	Yes	No	12	9	5
254	S:S:H79	S:S:Y157	6.53	Yes	No	12	9	7
255	S:S:H79	S:S:W161	7.41	Yes	Yes	0	9	9
256	S:S:D84	S:S:L80	5.43	Yes	No	0	9	9
257	S:S:L80	S:S:N298	6.87	No	Yes	0	9	9
258	S:S:N298	S:S:S81	5.96	Yes	No	0	9	9
259	S:S:A83	S:S:W161	3.89	No	Yes	0	8	9
260	S:S:D84	S:S:N119	5.39	Yes	No	3	9	8
261	S:S:D84	S:S:H294	5.04	Yes	Yes	3	9	9
262	S:S:C295	S:S:D84	9.34	No	Yes	3	9	9
263	S:S:F87	S:S:L91	8.53	Yes	No	0	7	8
264	S:S:F87	S:S:Y116	4.13	Yes	Yes	0	7	6
265	S:S:F87	S:S:N119	15.71	Yes	No	0	7	8
266	S:S:F292	S:S:F87	11.79	Yes	Yes	0	7	7
267	S:S:I115	S:S:T90	9.12	No	No	0	5	6
268	S:S:L91	S:S:W94	5.69	No	Yes	0	8	7
269	S:S:F104	S:S:F93	16.08	No	No	0	7	6
270	S:S:F93	S:S:L108	3.65	No	No	0	6	5
271	S:S:F93	S:S:V112	3.93	No	No	0	6	5
272	S:S:W94	S:S:Y116	7.72	Yes	Yes	2	7	6
273	S:S:E288	S:S:W94	4.36	Yes	Yes	2	5	7
274	S:S:F292	S:S:W94	5.01	Yes	Yes	2	7	7
275	K:K:?1	S:S:W94	18.94	Yes	Yes	2	0	7
276	S:S:F104	S:S:V96	6.55	No	No	0	7	5
277	S:S:D97	S:S:W102	6.7	No	Yes	2	5	9
278	S:S:D97	S:S:R183	4.76	No	Yes	2	5	3
279	K:K:?1	S:S:D97	22.56	Yes	No	2	0	5
280	S:S:A100	S:S:Y103	4	No	No	0	5	3
281	S:S:N101	S:S:Y103	10.47	No	No	0	4	3
282	S:S:N101	S:S:R183	7.23	No	Yes	0	4	3
283	S:S:N101	S:S:Y184	5.81	No	No	0	4	5
284	S:S:F104	S:S:W102	11.02	No	Yes	0	7	9
285	S:S:C109	S:S:W102	3.92	No	Yes	2	9	9
286	S:S:V112	S:S:W102	3.68	No	Yes	0	5	9
287	S:S:V177	S:S:W102	3.68	No	Yes	0	4	9
288	S:S:C186	S:S:W102	16.98	No	Yes	2	9	9
289	S:S:K110	S:S:N106	4.2	No	No	13	7	3
290	S:S:N106	S:S:N176	8.17	No	No	13	3	4
291	S:S:N106	S:S:V177	4.43	No	No	0	3	4
292	S:S:C109	S:S:C186	7.28	No	No	2	9	9
293	S:S:K110	S:S:N176	5.6	No	No	13	7	4
294	S:S:D171	S:S:H113	6.3	No	Yes	2	4	6
295	S:S:A175	S:S:H113	5.85	No	Yes	0	4	6
296	S:S:H113	S:S:R188	11.28	Yes	No	2	6	5
297	K:K:?1	S:S:H113	4.86	Yes	Yes	2	0	6
298	S:S:T168	S:S:V114	11.11	No	No	0	6	5
299	S:S:L120	S:S:Y116	14.07	No	Yes	0	7	6
300	S:S:E288	S:S:Y116	6.73	Yes	Yes	2	5	6
301	K:K:?1	S:S:Y116	7.97	Yes	Yes	2	0	6
302	S:S:T117	S:S:Y121	6.24	No	Yes	0	5	7
303	S:S:T117	S:S:T168	6.28	No	No	0	5	6
304	S:S:D171	S:S:T117	10.12	No	No	0	4	5
305	S:S:H294	S:S:N119	5.1	Yes	No	3	9	8
306	S:S:L120	S:S:W252	4.56	No	Yes	0	7	9
307	S:S:L167	S:S:Y121	9.38	No	Yes	14	5	7
308	S:S:H203	S:S:Y121	9.8	No	Yes	0	4	7
309	S:S:V206	S:S:Y121	15.14	No	Yes	14	4	7
310	S:S:S122	S:S:W161	6.18	No	Yes	0	7	9
311	S:S:F248	S:S:S123	3.96	Yes	No	0	9	9
312	S:S:V124	S:S:W125	3.68	No	No	3	7	5
313	S:S:P211	S:S:V124	7.07	No	No	3	9	7
314	S:S:F248	S:S:V124	5.24	Yes	No	3	9	7
315	S:S:A128	S:S:W125	3.89	No	No	0	7	5
316	S:S:P211	S:S:W125	16.21	No	No	3	9	5
317	S:S:F248	S:S:L127	9.74	Yes	No	0	9	8
318	S:S:F129	S:S:L151	3.65	Yes	No	11	5	4
319	S:S:F129	S:S:V155	5.24	Yes	No	11	5	2
320	S:S:F129	S:S:V160	5.24	Yes	No	0	5	7
321	S:S:I215	S:S:S131	7.74	No	No	0	7	9
322	S:S:C218	S:S:S131	5.16	No	No	0	6	9
323	S:S:S131	S:S:Y219	3.82	No	No	0	9	8
324	S:S:D133	S:S:R148	15.48	No	Yes	10	8	6
325	S:S:A137	S:S:R134	4.15	No	Yes	0	8	9
326	S:S:I138	S:S:R134	3.76	No	Yes	0	8	9
327	S:S:A237	S:S:R134	4.15	No	Yes	0	7	9
328	S:S:R134	S:S:T241	6.47	Yes	No	0	9	7
329	S:S:L136	S:S:Y135	4.69	No	Yes	0	5	8
330	S:S:V139	S:S:Y135	8.83	No	Yes	15	7	8
331	S:S:H140	S:S:Y135	9.8	No	Yes	15	6	8
332	S:S:I221	S:S:Y135	7.25	No	Yes	0	4	8
333	S:S:L136	S:S:R148	4.86	No	Yes	0	5	6
334	S:S:A137	S:S:R148	6.91	No	Yes	0	8	6
335	S:S:I138	S:S:I222	5.89	No	No	0	8	8
336	S:S:H140	S:S:V139	5.54	No	No	15	6	7
337	S:S:N143	S:S:T142	7.31	No	No	0	5	5
338	S:S:R148	S:S:S144	6.59	Yes	No	0	6	5
339	S:S:K149	S:S:Q145	4.07	No	No	0	6	5
340	S:S:P147	S:S:R146	4.32	No	No	0	4	5
341	S:S:E153	S:S:K149	8.1	No	No	0	7	6
342	S:S:K154	S:S:L150	4.23	No	No	0	3	4
343	S:S:L151	S:S:V155	4.47	No	No	11	4	2
344	S:S:V156	S:S:Y157	5.05	No	No	12	5	7
345	S:S:L167	S:S:V206	4.47	No	No	14	5	4
346	S:S:F199	S:S:P170	5.78	Yes	No	0	5	8
347	S:S:D171	S:S:R188	8.34	No	No	2	4	5
348	S:S:F174	S:S:I173	8.79	Yes	No	0	4	3
349	S:S:F174	S:S:Y190	13.41	Yes	Yes	2	4	4
350	S:S:F174	S:S:W195	8.02	Yes	Yes	2	4	5
351	S:S:F174	S:S:F199	4.29	Yes	Yes	2	4	5
352	S:S:V177	S:S:Y184	3.79	No	No	0	4	5
353	S:S:E179	S:S:Y184	6.73	No	No	0	2	5
354	S:S:I185	S:S:R183	6.26	No	Yes	0	3	3
355	K:K:?1	S:S:R183	6.43	Yes	Yes	2	0	3
356	K:K:?1	S:S:D187	7.18	Yes	No	0	0	3
357	S:S:R188	S:S:Y190	10.29	No	Yes	2	5	4
358	S:S:W195	S:S:Y190	10.61	Yes	Yes	2	5	4
359	S:S:F199	S:S:Y190	11.35	Yes	Yes	2	5	4
360	S:S:P191	S:S:W195	13.51	No	Yes	0	5	5
361	S:S:L194	S:S:N192	5.49	Yes	No	0	2	1
362	S:S:N192	S:S:W195	5.65	No	Yes	0	1	5
363	S:S:F199	S:S:W195	5.01	Yes	Yes	2	5	5
364	S:S:I204	S:S:Q200	8.23	No	No	0	5	5
365	S:S:I259	S:S:Q200	5.49	Yes	No	0	5	5
366	S:S:I209	S:S:M205	5.83	No	Yes	0	4	4
367	S:S:L208	S:S:Y256	18.76	No	No	0	8	8
368	S:S:V242	S:S:Y219	3.79	No	No	0	4	8
369	S:S:I245	S:S:Y219	3.63	No	No	0	7	8
370	S:S:K230	S:S:Q233	8.14	No	No	0	5	5
371	S:S:H232	S:S:K236	5.24	No	No	0	4	8
372	S:S:I243	S:S:L301	4.28	No	No	0	5	7
373	S:S:L244	S:S:L301	5.54	No	No	0	7	7
374	S:S:F248	S:S:F249	9.65	Yes	No	0	9	4
375	S:S:F248	S:S:W252	10.02	Yes	Yes	3	9	9
376	S:S:F248	S:S:H294	6.79	Yes	Yes	3	9	9
377	S:S:C251	S:S:L297	4.76	No	No	0	8	6
378	S:S:W252	S:S:Y255	7.72	Yes	Yes	0	9	7
379	S:S:W252	S:S:Y256	12.54	Yes	No	0	9	8
380	S:S:A291	S:S:W252	7.78	No	Yes	0	8	9
381	S:S:H294	S:S:W252	10.58	Yes	Yes	3	9	9
382	S:S:I257	S:S:L253	4.28	No	No	0	6	5
383	S:S:I259	S:S:Y255	10.88	Yes	Yes	0	5	7
384	S:S:T287	S:S:Y255	4.99	No	Yes	0	6	7
385	S:S:E288	S:S:Y255	8.98	Yes	Yes	0	5	7
386	S:S:I259	S:S:I284	5.89	Yes	No	0	5	4
387	S:S:I261	S:S:V280	4.61	No	Yes	0	5	5
388	S:S:D262	S:S:V280	4.38	No	Yes	0	5	5
389	S:S:D262	S:S:H281	11.35	No	No	0	5	4
390	S:S:D262	S:S:I284	4.2	No	No	0	5	4
391	S:S:F264	S:S:I269	13.82	No	No	0	4	1
392	S:S:F264	S:S:I270	3.77	No	No	0	4	5
393	S:S:F276	S:S:I265	3.77	No	No	16	1	3
394	S:S:E277	S:S:I265	8.2	No	No	0	2	3
395	S:S:I265	S:S:V280	4.61	No	Yes	16	3	5
396	S:S:I269	S:S:L267	4.28	No	No	0	1	1
397	S:S:E268	S:S:K271	12.15	No	No	0	2	3
398	S:S:F276	S:S:Q272	15.23	No	No	0	1	2
399	S:S:F276	S:S:V280	3.93	No	Yes	16	1	5
400	S:S:K282	S:S:W283	6.96	No	No	0	2	6
401	S:S:I286	S:S:W283	8.22	No	No	0	6	6
402	S:S:E288	S:S:F292	7	Yes	Yes	2	5	7
403	K:K:?1	S:S:E288	11.02	Yes	Yes	2	0	5
404	S:S:C296	S:S:F293	5.59	No	No	0	7	5
405	S:S:C295	S:S:H294	7.37	No	Yes	3	9	9
406	S:S:N298	S:S:P299	6.52	Yes	No	0	9	9
407	S:S:N298	S:S:Y302	4.65	Yes	Yes	8	9	9
408	S:S:A303	S:S:F304	4.16	No	No	0	7	6
409	S:S:F304	S:S:F309	9.65	No	No	17	6	8
410	S:S:D187	S:S:F189	3.58	No	No	0	3	3
411	R:R:G258	R:R:I284	3.53	No	No	0	4	4
412	S:S:G258	S:S:I284	3.53	No	No	0	4	4
413	R:R:I286	R:R:W283	3.52	No	No	0	6	6
414	S:S:F199	S:S:Q202	3.51	Yes	No	0	5	3
415	R:R:P254	R:R:T287	3.5	No	No	0	9	6
416	S:S:P254	S:S:T287	3.5	No	No	0	9	6
417	R:R:E32	R:R:R30	3.49	No	No	0	4	5
418	S:S:E32	S:S:R30	3.49	No	No	0	4	5
419	R:R:G64	R:R:L78	3.42	No	No	0	2	5
420	R:R:C295	R:R:V88	3.42	No	No	0	9	6
421	S:S:C295	S:S:V88	3.42	No	No	0	9	6
422	R:R:I162	R:R:P163	3.39	No	No	0	4	4
423	R:R:I169	R:R:P170	3.39	No	No	0	3	8
424	S:S:I162	S:S:P163	3.39	No	No	0	4	4
425	S:S:I169	S:S:P170	3.39	No	No	0	3	8
426	R:R:Q202	R:R:Y121	3.38	No	Yes	0	3	7
427	S:S:C296	S:S:T51	3.38	No	No	0	7	5
428	R:R:L253	R:R:P254	3.28	No	No	0	5	9
429	S:S:L253	S:S:P254	3.28	No	No	0	5	9
430	R:R:C296	R:R:I48	3.27	No	No	0	7	7
431	R:R:A289	R:R:I44	3.25	No	No	0	4	5
432	S:S:A289	S:S:I44	3.25	No	No	0	4	5
433	S:S:V156	S:S:V160	3.21	No	No	0	5	7
434	S:S:C218	S:S:L132	3.17	No	No	0	6	6
435	R:R:A247	R:R:L297	3.15	No	No	0	6	6
436	S:S:A247	S:S:L297	3.15	No	No	0	6	6
437	R:R:T241	R:R:T73	3.14	No	No	0	7	7
438	R:R:T117	R:R:T168	3.14	Yes	No	0	5	6
439	S:S:T241	S:S:T73	3.14	No	No	0	7	7
440	R:R:I138	R:R:S229	3.1	Yes	No	0	8	5
441	R:R:I60	R:R:V82	3.07	No	No	0	7	5
442	S:S:I60	S:S:V82	3.07	No	No	0	7	5
443	R:R:I47	R:R:T51	3.04	No	No	0	4	5
444	R:R:K225	R:R:V139	3.04	No	No	0	4	7
445	R:R:K282	R:R:T279	3	No	No	0	2	2
446	S:S:L41	S:S:S285	3	No	No	0	6	5
447	S:S:L165	S:S:V118	2.98	No	No	0	3	5
448	S:S:L132	S:S:V214	2.98	No	No	0	6	6
449	S:S:L246	S:S:V242	2.98	No	No	0	5	4
450	S:S:C251	S:S:H294	2.95	No	Yes	0	8	9
451	R:R:I204	R:R:I209	2.94	No	No	0	5	4
452	R:R:I209	R:R:I213	2.94	No	No	0	4	3
453	R:R:I259	R:R:I284	2.94	Yes	No	0	5	4
454	R:R:I265	R:R:I270	2.94	No	No	0	3	5
455	S:S:I204	S:S:I209	2.94	No	No	0	5	4
456	R:R:G207	R:R:Y121	2.9	No	Yes	0	5	7
457	S:S:G207	S:S:Y121	2.9	No	Yes	0	5	7
458	R:R:F29	R:R:P27	2.89	No	No	0	4	5
459	R:R:Q314	R:R:S312	2.89	No	No	0	5	6
460	S:S:Q314	S:S:S312	2.89	No	No	0	5	6
461	S:S:K67	S:S:M63	2.88	No	Yes	0	6	6
462	S:S:K308	S:S:K310	2.87	No	No	0	6	8
463	R:R:I48	R:R:L91	2.85	No	Yes	0	7	8
464	R:R:I138	R:R:L226	2.85	Yes	No	0	8	8
465	R:R:I162	R:R:L166	2.85	No	No	0	4	4
466	S:S:I44	S:S:L290	2.85	No	No	0	5	7
467	S:S:I48	S:S:L91	2.85	No	No	0	7	8
468	S:S:I53	S:S:L85	2.85	No	No	0	5	7
469	S:S:I89	S:S:L85	2.85	No	No	0	4	7
470	S:S:I245	S:S:L127	2.85	No	No	0	7	8
471	S:S:I138	S:S:L238	2.85	No	No	0	8	5
472	S:S:I162	S:S:L166	2.85	No	No	0	4	4
473	S:S:I222	S:S:L226	2.85	No	No	0	8	8
474	S:S:I286	S:S:L290	2.85	No	No	0	6	7
475	R:R:L210	R:R:M205	2.83	No	No	0	6	4
476	S:S:L210	S:S:M205	2.83	No	Yes	0	6	4
477	R:R:G105	R:R:W102	2.81	No	Yes	0	8	9
478	R:R:K282	R:R:N37	2.8	No	No	0	2	3
479	S:S:K282	S:S:N33	2.8	No	No	0	2	6
480	S:S:C251	S:S:F293	2.79	No	No	0	8	5
481	R:R:L244	R:R:L80	2.77	No	No	0	7	9
482	R:R:L127	R:R:L244	2.77	No	No	0	8	7
483	R:R:L244	R:R:L301	2.77	No	No	0	7	7
484	R:R:A307	R:R:F304	2.77	No	No	0	5	6
485	S:S:L127	S:S:L244	2.77	No	No	0	8	7
486	S:S:A307	S:S:F304	2.77	No	No	17	5	6
487	S:S:A307	S:S:F309	2.77	No	No	17	5	8
488	R:R:I204	R:R:Q200	2.74	No	No	0	5	5
489	R:R:H315	R:R:T311	2.74	No	No	0	4	4
490	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
491	S:S:A95	S:S:Y45	2.67	No	Yes	0	7	7
492	R:R:H79	R:R:I126	2.65	Yes	No	0	9	7
493	S:S:F189	S:S:S178	2.64	No	No	0	3	1
494	S:S:E31	S:S:N278	2.63	No	No	0	5	3
495	R:R:V198	S:S:F201	2.62	No	No	0	3	4
496	R:R:F201	S:S:V198	2.62	No	No	0	4	3
497	S:S:F172	S:S:V114	2.62	No	No	0	4	5
498	R:R:A83	R:R:W161	2.59	No	Yes	0	8	9
499	R:R:F87	R:R:T90	2.59	Yes	No	0	7	6
500	S:S:R77	S:S:T240	2.59	No	No	0	8	7
501	S:S:F87	S:S:T90	2.59	Yes	No	0	7	6
502	R:R:V196	R:R:Y190	2.52	No	Yes	0	4	4
503	S:S:V196	S:S:Y190	2.52	No	Yes	0	4	4
504	S:S:F293	S:S:I300	2.51	No	No	0	5	6
505	R:R:F201	R:R:M205	2.49	No	No	0	4	4
506	S:S:F201	S:S:M205	2.49	No	Yes	0	4	4
507	R:R:F172	R:R:K110	2.48	No	No	0	4	7
508	R:R:V118	R:R:W161	2.45	No	Yes	0	5	9
509	S:S:V82	S:S:W161	2.45	No	Yes	0	5	9
510	R:R:F93	R:R:L108	2.44	No	Yes	1	6	5
511	R:R:F104	R:R:L108	2.44	Yes	Yes	1	7	5
512	R:R:F107	R:R:L108	2.44	No	Yes	0	1	5
513	S:S:T279	S:S:W283	2.43	No	No	0	2	6
514	S:S:D181	S:S:R30	2.38	No	No	0	2	5
515	R:R:L305	R:R:Y302	2.34	No	Yes	0	6	9
516	S:S:L61	S:S:Y65	2.34	No	No	0	4	5
517	S:S:G159	S:S:P163	2.03	No	No	0	3	4
518	K:K:?1	S:S:E32	2	Yes	No	0	0	4
519	R:R:A95	R:R:P42	1.87	No	No	0	7	5
520	R:R:A98	R:R:P42	1.87	No	No	0	5	5
521	S:S:A95	S:S:P42	1.87	No	No	0	7	5
522	S:S:A98	S:S:P42	1.87	No	No	0	5	5
523	R:R:G55	R:R:V54	1.84	No	No	0	8	4
524	R:R:G159	R:R:V158	1.84	No	No	0	3	4
525	S:S:G159	S:S:V158	1.84	No	No	0	3	4
526	R:R:G52	R:R:T51	1.82	No	No	0	8	5
527	R:R:G57	R:R:I60	1.76	No	No	0	3	7
528	S:S:G57	S:S:I60	1.76	No	No	0	3	7
529	R:R:G231	R:R:K234	1.74	No	No	0	4	7
530	S:S:G231	S:S:K234	1.74	No	No	0	4	7
531	R:R:A95	R:R:S46	1.71	No	No	0	7	5
532	S:S:A95	S:S:S46	1.71	No	No	0	7	5
533	S:S:A164	S:S:S122	1.71	No	No	0	7	7
534	R:R:L136	R:R:P147	1.64	No	No	0	5	4
535	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
536	R:R:C296	R:R:I300	1.64	No	No	0	7	6
537	S:S:L136	S:S:P147	1.64	No	No	0	5	4
538	S:S:G273	S:S:Q272	1.64	No	No	0	5	2
539	S:S:S224	S:S:S227	1.63	No	No	0	4	4
540	R:R:A180	R:R:I185	1.62	No	No	0	1	3
541	S:S:S122	S:S:V118	1.62	No	No	0	7	5
542	S:S:A180	S:S:I185	1.62	No	No	0	1	3
543	R:R:A111	R:R:L108	1.58	No	Yes	0	4	5
544	S:S:A111	S:S:L108	1.58	No	No	0	4	5
545	R:R:A34	R:R:N33	1.56	No	No	0	1	6
546	R:R:I213	R:R:S217	1.55	No	No	0	3	3
547	R:R:I259	R:R:S263	1.55	Yes	No	0	5	5
548	S:S:I213	S:S:S217	1.55	No	No	0	3	3
549	S:S:I223	S:S:S224	1.55	No	No	0	4	4
550	S:S:I259	S:S:S263	1.55	Yes	No	0	5	5
551	R:R:C28	R:R:E277	1.52	No	No	0	9	2
552	R:R:I39	R:R:T43	1.52	No	No	0	5	4
553	R:R:I47	R:R:T43	1.52	No	No	0	4	4
554	R:R:K67	R:R:V62	1.52	No	No	0	6	7
555	S:S:C28	S:S:E277	1.52	No	No	0	9	2
556	S:S:I39	S:S:T43	1.52	No	No	0	5	4
557	S:S:I47	S:S:T43	1.52	No	No	0	4	4
558	S:S:I47	S:S:T51	1.52	No	No	0	4	5
559	S:S:K225	S:S:V139	1.52	No	No	0	4	7
560	S:S:K154	S:S:V155	1.52	No	No	0	3	2
561	S:S:F129	S:S:G159	1.51	Yes	No	0	5	3
562	R:R:L58	R:R:V54	1.49	No	No	0	5	4
563	R:R:L58	R:R:V62	1.49	No	No	0	5	7
564	R:R:L246	R:R:V242	1.49	No	No	0	5	4
565	S:S:L58	S:S:V54	1.49	No	No	0	5	4
566	S:S:L58	S:S:V62	1.49	No	No	0	5	7
567	S:S:L86	S:S:V118	1.49	No	No	0	7	5
568	R:R:C251	R:R:H294	1.47	No	Yes	0	8	9
569	R:R:L317	R:R:T318	1.47	No	No	0	5	4
570	S:S:I209	S:S:I213	1.47	No	No	0	4	3
571	S:S:L317	S:S:T318	1.47	No	No	0	5	4
572	R:R:I243	R:R:K239	1.45	No	No	0	5	6
573	S:S:I243	S:S:K239	1.45	No	No	0	5	6
574	R:R:K149	R:R:M72	1.44	No	Yes	0	6	6
575	R:R:K308	R:R:K310	1.44	No	No	0	6	8
576	S:S:Q233	S:S:S71	1.44	No	No	0	5	7
577	S:S:K230	S:S:K234	1.44	No	No	0	5	7
578	R:R:I44	R:R:L290	1.43	No	No	0	5	7
579	R:R:Q66	R:R:V62	1.43	No	No	0	4	7
580	R:R:I169	R:R:L166	1.43	No	No	0	3	4
581	R:R:I286	R:R:L290	1.43	No	No	0	6	7
582	S:S:Q314	S:S:T318	1.42	No	No	0	5	4
583	R:R:K154	R:R:L150	1.41	No	No	0	3	4
584	S:S:G105	S:S:W102	1.41	No	Yes	0	8	9
585	R:R:H228	R:R:S227	1.39	No	No	0	5	4
586	S:S:A111	S:S:F107	1.39	No	No	0	4	1
587	S:S:H228	S:S:S227	1.39	No	No	0	5	4
588	S:S:H315	S:S:S312	1.39	No	No	0	4	6
589	R:R:L194	S:S:L266	1.38	Yes	No	0	2	3
590	S:S:H315	S:S:T311	1.37	No	No	0	4	4
591	R:R:K149	R:R:Q145	1.36	No	No	0	6	5
592	R:R:K230	R:R:Q233	1.36	No	No	0	5	5
593	S:S:K67	S:S:Q66	1.36	No	No	0	6	4
594	R:R:E153	R:R:K154	1.35	No	No	0	7	3
595	R:R:A164	R:R:Y121	1.33	No	Yes	0	7	7
596	R:R:R77	R:R:T240	1.29	No	No	0	8	7
597	S:S:F49	S:S:L50	1.22	No	No	0	6	5
598	R:R:N278	R:R:R30	1.21	No	No	0	3	5
599	S:S:L305	S:S:Y302	1.17	No	Yes	0	6	9
600	R:R:H232	R:R:R235	1.13	No	No	0	4	5
601	S:S:H232	S:S:R235	1.13	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y45	6.338	5	1	7
2	R:R:I53	6.3625	4	4	5
3	R:R:M72	5.8075	4	0	6
4	R:R:Y76	5.4775	4	0	7
5	R:R:H79	6.305	4	6	9
6	R:R:D84	7.6425	4	1	9
7	R:R:F87	7.282	5	1	7
8	R:R:L91	4.2425	4	1	8
9	R:R:W94	7.40286	7	1	7
10	R:R:W102	7.87571	7	1	9
11	R:R:F104	10.8125	4	1	7
12	R:R:L108	2.225	4	1	5
13	R:R:H113	7.145	4	1	6
14	R:R:Y116	8.88	4	1	6
15	R:R:T117	5.8525	4	1	5
16	R:R:Y121	6.17286	7	1	7
17	R:R:F129	6.44	4	0	5
18	R:R:R134	5.575	4	0	9
19	R:R:Y135	7.3275	4	7	8
20	R:R:I138	4.03	4	0	8
21	R:R:R148	8.1625	4	0	6
22	R:R:W161	4.3925	4	0	9
23	R:R:Y190	9.842	5	1	4
24	R:R:L194	6.4	5	0	2
25	R:R:W195	10.1467	6	1	5
26	R:R:Y219	4.478	5	0	8
27	R:R:F248	7.20667	6	1	9
28	R:R:W252	9.15	6	1	9
29	R:R:Y255	7.6625	4	0	7
30	R:R:I259	5.4775	4	0	5
31	R:R:E288	7.17	5	1	5
32	R:R:F292	7.79	4	1	7
33	R:R:H294	7.23	6	1	9
34	R:R:N298	8.46	4	0	9
35	R:R:Y302	12.0575	4	5	9
36	S:S:Y45	6.165	4	2	7
37	S:S:M63	4.715	4	9	6
38	S:S:M72	6.6725	4	10	6
39	S:S:H79	6.9025	4	12	9
40	S:S:D84	6.118	5	3	9
41	S:S:F87	8.55	5	0	7
42	S:S:W94	8.56167	6	2	7
43	S:S:W102	6.77	7	2	9
44	S:S:H113	7.0725	4	2	6
45	S:S:Y116	8.124	5	2	6
46	S:S:Y121	8.692	5	14	7
47	S:S:F129	4.778	5	11	5
48	S:S:R134	4.6325	4	0	9
49	S:S:Y135	7.6425	4	15	8
50	S:S:R148	7.76	5	10	6
51	S:S:W161	4.9825	4	0	9
52	S:S:F174	8.6275	4	2	4
53	S:S:R183	6.17	4	2	3
54	S:S:Y190	9.636	5	2	4
55	S:S:L194	5.63	4	0	2
56	S:S:W195	10.36	6	2	5
57	S:S:F199	5.988	5	2	5
58	S:S:M205	3.87	4	0	4
59	S:S:F248	7.56667	6	3	9
60	S:S:W252	8.86667	6	3	9
61	S:S:Y255	8.1425	4	0	7
62	S:S:I259	5.9525	4	0	5
63	S:S:V280	4.3825	4	16	5
64	S:S:E288	7.618	5	2	5
65	S:S:F292	6.9825	4	2	7
66	S:S:H294	6.305	6	3	9
67	S:S:N298	7.452	5	8	9
68	S:S:Y302	10.368	5	8	9
69	W:W:?1	9.61889	9	1	0
70	K:K:?1	10.12	8	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I259	R:R:Y255	10.3112	13.3	Yes	Yes	0	5	7
2	R:R:E288	R:R:Y255	40.5622	5.61	Yes	Yes	0	5	7
3	R:R:E288	W:W:?1	37.0086	11.02	Yes	Yes	1	5	0
4	R:R:W94	R:R:Y45	13.2273	9.65	Yes	Yes	1	7	7
5	R:R:L41	R:R:Y45	15.4305	10.55	No	Yes	0	6	7
6	R:R:L41	R:R:N37	13.7403	5.49	No	No	0	6	3
7	R:R:W252	R:R:Y255	33.7809	6.75	Yes	Yes	0	9	7
8	R:R:H294	R:R:W252	13.8151	13.75	Yes	Yes	1	9	9
9	R:R:C295	R:R:H294	17.1115	8.85	No	Yes	1	9	9
10	R:R:C295	R:R:V88	22.0651	3.42	No	No	0	9	6
11	R:R:I53	R:R:V88	13.28	6.14	Yes	No	0	5	6
12	R:R:D84	R:R:N56	14.4205	5.39	Yes	No	0	9	9
13	R:R:F248	R:R:W252	47.2128	9.02	Yes	Yes	1	9	9
14	R:R:F248	R:R:L127	47.5533	8.53	Yes	No	0	9	8
15	R:R:N298	R:R:R77	10.1325	13.26	Yes	No	0	9	8
16	R:R:I245	R:R:L127	43.5722	4.28	No	No	0	7	8
17	R:R:I245	R:R:Y219	42.8058	3.63	No	Yes	0	7	8
18	R:R:T241	R:R:Y219	32.5847	4.99	No	Yes	0	7	8
19	R:R:R134	R:R:T241	31.0136	7.76	Yes	No	0	9	7
20	R:R:A137	R:R:R134	28.7486	4.15	No	Yes	0	8	9
21	R:R:A137	R:R:R148	27.9532	6.91	No	Yes	0	8	6
22	R:R:D133	R:R:R148	19.1024	14.29	No	Yes	0	8	6
23	R:R:D133	R:R:M72	18.2886	8.32	No	Yes	0	8	6
24	R:R:A152	R:R:M72	12.5494	4.83	No	Yes	0	3	6
25	R:R:A152	R:R:Y76	11.7234	4	No	Yes	0	3	7
26	R:R:H294	R:R:N119	11.7983	3.83	Yes	No	1	9	8
27	R:R:F87	R:R:W94	26.3524	4.01	Yes	Yes	1	7	7
28	R:R:H113	W:W:?1	100	3.89	Yes	Yes	1	6	0
29	R:R:H113	R:R:R188	96.8602	11.28	Yes	No	1	6	5
30	R:R:L120	R:R:W252	29.667	5.69	No	Yes	0	7	9
31	R:R:R188	R:R:Y190	99.7008	8.23	No	Yes	1	5	4
32	R:R:W195	R:R:Y190	96.6945	10.61	Yes	Yes	1	5	4
33	R:R:N192	R:R:W195	98.8763	5.65	No	Yes	0	1	5
34	R:R:L194	R:R:N192	98.6908	8.24	Yes	No	0	2	1
35	R:R:D193	R:R:L194	98.4221	5.43	No	Yes	0	1	2
36	R:R:D193	S:S:L194	98.3511	5.43	No	Yes	0	1	2
37	S:S:L194	S:S:N192	98.1289	5.49	Yes	No	0	2	1
38	S:S:N192	S:S:W195	97.893	5.65	No	Yes	0	1	5
39	S:S:W195	S:S:Y190	95.7288	10.61	Yes	Yes	2	5	4
40	S:S:R188	S:S:Y190	96.9105	10.29	No	Yes	2	5	4
41	S:S:H113	S:S:R188	93.5524	11.28	Yes	No	2	6	5
42	K:K:?1	S:S:H113	95.5112	4.86	Yes	Yes	2	0	6
43	K:K:?1	S:S:E288	27.8616	11.02	Yes	Yes	2	0	5
44	S:S:E288	S:S:Y255	29.6662	8.98	Yes	Yes	0	5	7
45	S:S:I259	S:S:Y255	15.6419	10.88	Yes	Yes	0	5	7
46	K:K:?1	S:S:Y116	53.191	7.97	Yes	Yes	2	0	6
47	S:S:F87	S:S:Y116	38.6903	4.13	Yes	Yes	0	7	6
48	S:S:F87	S:S:N119	40.382	15.71	Yes	No	0	7	8
49	S:S:D84	S:S:N119	34.1886	5.39	Yes	No	3	9	8
50	S:S:D84	S:S:L80	35.4009	5.43	Yes	No	0	9	9
51	S:S:L80	S:S:N298	35.0153	6.87	No	Yes	0	9	9
52	S:S:N298	S:S:Y302	34.0115	4.65	Yes	Yes	8	9	9
53	S:S:D74	S:S:Y302	33.4916	8.05	No	Yes	0	8	9
54	S:S:D74	S:S:M63	31.0457	5.54	No	Yes	0	8	6
55	S:S:M63	S:S:R70	29.3365	6.2	Yes	No	9	6	6
56	S:S:K75	S:S:R70	28.9655	4.95	No	No	0	6	6
57	S:S:K75	S:S:M72	27.2738	7.2	No	Yes	0	6	6
58	S:S:A152	S:S:M72	17.9917	4.83	No	Yes	0	3	6
59	S:S:A152	S:S:Y76	17.5329	5.34	No	No	0	3	7
60	S:S:F129	S:S:Y76	16.6107	8.25	Yes	No	0	5	7
61	S:S:F129	S:S:V160	11.9082	5.24	Yes	No	0	5	7
62	S:S:V156	S:S:V160	11.4295	3.21	No	No	0	5	7
63	S:S:H79	S:S:V156	10.4516	9.69	Yes	No	12	9	5
64	S:S:L120	S:S:Y116	15.0015	14.07	No	Yes	0	7	6
65	S:S:L120	S:S:W252	14.735	4.56	No	Yes	0	7	9
66	S:S:H294	S:S:W252	13.3838	10.58	Yes	Yes	3	9	9
67	S:S:W252	S:S:Y255	18.5634	7.72	Yes	Yes	0	9	7
68	K:K:?1	S:S:D97	10.6257	22.56	Yes	No	2	0	5
69	S:S:D97	S:S:W102	10.1883	6.7	No	Yes	2	5	9
70	S:S:F248	S:S:W252	16.9924	10.02	Yes	Yes	3	9	9
71	S:S:F248	S:S:L127	12.7708	9.74	Yes	No	0	9	8
72	S:S:C251	S:S:H294	12.2899	2.95	No	Yes	0	8	9
73	R:R:W94	W:W:?1	32.9992	16.35	Yes	Yes	1	7	0
74	R:R:D84	R:R:N119	19.207	6.73	Yes	No	1	9	8
75	R:R:F87	R:R:N119	31.2488	12.08	Yes	No	1	7	8
76	R:R:L120	R:R:Y116	29.8777	11.72	No	Yes	0	7	6
77	R:R:Y116	W:W:?1	28.6815	12.4	Yes	Yes	1	6	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:W94	S:S:Y45	9.65	2	Yes	Yes	7	7	1	2
S:S:F292	S:S:Y45	4.13	2	Yes	Yes	7	7	2	2
S:S:F87	S:S:L91	8.53	0	Yes	No	7	8	2	2
S:S:F87	S:S:Y116	4.13	0	Yes	Yes	7	6	2	1
S:S:F292	S:S:F87	11.79	2	Yes	Yes	7	7	2	2
S:S:L91	S:S:W94	5.69	0	No	Yes	8	7	2	1
S:S:W94	S:S:Y116	7.72	2	Yes	Yes	7	6	1	1
S:S:E288	S:S:W94	4.36	2	Yes	Yes	5	7	1	1
S:S:F292	S:S:W94	5.01	2	Yes	Yes	7	7	2	1
K:K:?1	S:S:W94	18.94	2	Yes	Yes	0	7	0	1
S:S:D97	S:S:W102	6.7	2	No	Yes	5	9	1	2
S:S:D97	S:S:R183	4.76	2	No	Yes	5	3	1	1
K:K:?1	S:S:D97	22.56	2	Yes	No	0	5	0	1
S:S:N101	S:S:R183	7.23	0	No	Yes	4	3	2	1
S:S:D171	S:S:H113	6.3	2	No	Yes	4	6	2	1
S:S:A175	S:S:H113	5.85	0	No	Yes	4	6	2	1
S:S:H113	S:S:R188	11.28	2	Yes	No	6	5	1	2
K:K:?1	S:S:H113	4.86	2	Yes	Yes	0	6	0	1
S:S:L120	S:S:Y116	14.07	0	No	Yes	7	6	2	1
S:S:E288	S:S:Y116	6.73	2	Yes	Yes	5	6	1	1
K:K:?1	S:S:Y116	7.97	2	Yes	Yes	0	6	0	1
S:S:D171	S:S:R188	8.34	2	No	No	4	5	2	2
S:S:I185	S:S:R183	6.26	0	No	Yes	3	3	2	1
K:K:?1	S:S:R183	6.43	2	Yes	Yes	0	3	0	1
K:K:?1	S:S:D187	7.18	2	Yes	No	0	3	0	1
S:S:E288	S:S:Y255	8.98	2	Yes	Yes	5	7	1	2
S:S:E288	S:S:F292	7	2	Yes	Yes	5	7	1	2
K:K:?1	S:S:E288	11.02	2	Yes	Yes	0	5	0	1
S:S:D187	S:S:F189	3.58	0	No	No	3	3	1	2
S:S:E32	S:S:R30	3.49	0	No	No	4	5	1	2
K:K:?1	S:S:E32	2	2	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E32	W:W:?1	5.01	0	No	Yes	4	0	1	0
R:R:L91	R:R:Y45	4.69	1	Yes	Yes	8	7	2	2
R:R:W94	R:R:Y45	9.65	1	Yes	Yes	7	7	1	2
R:R:F292	R:R:Y45	4.13	1	Yes	Yes	7	7	2	2
R:R:F87	R:R:L91	4.87	1	Yes	Yes	7	8	2	2
R:R:F87	R:R:W94	4.01	1	Yes	Yes	7	7	2	1
R:R:F292	R:R:F87	12.86	1	Yes	Yes	7	7	2	2
R:R:L91	R:R:W94	4.56	1	Yes	Yes	8	7	2	1
R:R:W94	R:R:Y116	5.79	1	Yes	Yes	7	6	1	1
R:R:E288	R:R:W94	5.45	1	Yes	Yes	5	7	1	1
R:R:F292	R:R:W94	6.01	1	Yes	Yes	7	7	2	1
R:R:W94	W:W:?1	16.35	1	Yes	Yes	7	0	1	0
R:R:D97	R:R:W102	5.58	0	No	Yes	5	9	1	2
R:R:D97	W:W:?1	19.49	0	No	Yes	5	0	1	0
R:R:N101	R:R:R183	4.82	0	No	No	4	3	2	1
R:R:C109	R:R:W102	3.92	1	No	Yes	9	9	2	2
R:R:C186	R:R:W102	16.98	1	No	Yes	9	9	1	2
R:R:C109	R:R:C186	7.28	1	No	No	9	9	2	1
R:R:D171	R:R:H113	7.56	1	No	Yes	4	6	2	1
R:R:A175	R:R:H113	5.85	0	No	Yes	4	6	2	1
R:R:H113	R:R:R188	11.28	1	Yes	No	6	5	1	2
R:R:H113	W:W:?1	3.89	1	Yes	Yes	6	0	1	0
R:R:L120	R:R:Y116	11.72	0	No	Yes	7	6	2	1
R:R:E288	R:R:Y116	5.61	1	Yes	Yes	5	6	1	1
R:R:Y116	W:W:?1	12.4	1	Yes	Yes	6	0	1	0
R:R:D171	R:R:R188	8.34	1	No	No	4	5	2	2
R:R:I185	R:R:R183	6.26	0	No	No	3	3	2	1
R:R:R183	W:W:?1	6.43	0	No	Yes	3	0	1	0
R:R:C186	W:W:?1	4.8	1	No	Yes	9	0	1	0
R:R:D187	R:R:F189	4.78	0	No	No	3	3	1	2
R:R:D187	W:W:?1	7.18	0	No	Yes	3	0	1	0
R:R:E288	R:R:Y255	5.61	1	Yes	Yes	5	7	1	2
R:R:E288	R:R:F292	8.16	1	Yes	Yes	5	7	1	2
R:R:E288	W:W:?1	11.02	1	Yes	Yes	5	0	1	0
R:R:E32	R:R:R30	3.49	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	3ODU_poly
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR4
Species	Homo sapiens
Ligand	-
Other Ligand(s)	IT1t
Protein Partners	-
PDB Resolution	2.5
Date	2010-10-27
D.O.I.	10.1126/science.1194396

Net Summary
I_min	3.63
Number of Linked Nodes	551
Number of Links	601
Number of Hubs	70
Number of Links mediated by Hubs	277
Number of Communities	17
Number of Nodes involved in Communities	102
Number of Links involved in Communities	132

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	231879
Length Of Smallest Path	3
Average Path Length	22.7582
Length of Longest Path	60
Minimum Path Strength	1.38
Average Path Strength	7.30339
Maximum Path Strength	22.58
Minimum Path Correlation	0.77
Average Path Correlation	0.985202
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	70.1615
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.6697
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITD
PDB Residues	W:W:?1 K:K:?1
Environment Details	Open EMBL-EBI Page
Code	ITD
Name	(6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Synonyms
Identifier	(6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylcarbamimidothioate
Formula	C21 H34 N4 S2
Molecular Weight	406.651
SMILES	CC1(CN2C(=CSC2=N1)CS/C(=N\C3CCCCC3)/NC4CCCCC4)C
PubChem	25147749
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	64
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>3ODU_poly_Chain_R P C F R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V N L Y S S V W I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K F K T S A Q H A L T S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	2.5	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	-	CVX15	-	2.9	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.2	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/&β;1/&γ;2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/&β;1/&γ;2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/&β;1/&γ;2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	3ODU (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	2.5	2010-10-27	10.1126/science.1194396
	3OE8 (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396

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