psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:E32	5.01	Yes	No	0	0	4
2	L:L:?1	R:R:W94	16.35	Yes	Yes	1	0	7
3	L:L:?1	R:R:D97	19.49	Yes	No	1	0	5
4	L:L:?1	R:R:H113	3.89	Yes	Yes	1	0	6
5	L:L:?1	R:R:Y116	12.4	Yes	Yes	1	0	6
6	L:L:?1	R:R:R183	6.43	Yes	Yes	1	0	3
7	L:L:?1	R:R:C186	4.8	Yes	No	1	0	9
8	L:L:?1	R:R:D187	7.18	Yes	No	0	0	3
9	L:L:?1	R:R:E288	11.02	Yes	Yes	1	0	5
10	M:M:?1	S:S:W94	18.94	Yes	Yes	2	0	7
11	M:M:?1	S:S:D97	22.56	Yes	No	2	0	5
12	M:M:?1	S:S:W102	3.44	Yes	Yes	2	0	9
13	M:M:?1	S:S:H113	4.86	Yes	Yes	2	0	6
14	M:M:?1	S:S:Y116	7.97	Yes	Yes	2	0	6
15	M:M:?1	S:S:R183	6.43	Yes	Yes	2	0	3
16	M:M:?1	S:S:C186	3.6	Yes	No	2	0	9
17	M:M:?1	S:S:D187	7.18	Yes	No	0	0	3
18	M:M:?1	S:S:E288	11.02	Yes	Yes	2	0	5
19	R:R:C274	R:R:C28	7.28	No	No	0	5	9
20	R:R:E31	R:R:F29	4.66	No	No	0	5	4
21	R:R:E32	R:R:R30	3.49	No	No	0	4	5
22	R:R:H281	R:R:R30	28.21	No	No	0	4	5
23	R:R:N33	R:R:N35	10.9	No	No	0	6	3
24	R:R:N33	R:R:N37	12.26	No	No	0	6	3
25	R:R:A34	R:R:K38	8.03	No	No	0	1	4
26	R:R:F36	R:R:F40	18.22	No	No	0	4	5
27	R:R:L41	R:R:N37	5.49	No	No	0	6	3
28	R:R:F40	R:R:I44	6.28	No	No	0	5	5
29	R:R:F40	R:R:I286	6.28	No	No	0	5	6
30	R:R:L41	R:R:Y45	10.55	No	Yes	0	6	7
31	R:R:L41	R:R:S285	4.5	No	No	0	6	5
32	R:R:P42	R:R:V99	5.3	No	No	0	5	4
33	R:R:L91	R:R:Y45	4.69	Yes	Yes	1	8	7
34	R:R:W94	R:R:Y45	9.65	Yes	Yes	1	7	7
35	R:R:F292	R:R:Y45	4.13	Yes	Yes	1	7	7
36	R:R:F293	R:R:I48	12.56	No	No	0	5	7
37	R:R:F49	R:R:L50	4.87	No	No	0	6	5
38	R:R:F49	R:R:I53	6.28	No	Yes	0	6	5
39	R:R:F49	R:R:P92	10.11	No	No	0	6	9
40	R:R:G52	R:R:V88	3.68	No	No	0	8	6
41	R:R:I53	R:R:L85	7.14	Yes	No	6	5	7
42	R:R:I53	R:R:V88	6.14	Yes	No	0	5	6
43	R:R:I53	R:R:I89	5.89	Yes	No	6	5	4
44	R:R:G55	R:R:P299	4.06	No	Yes	0	8	9
45	R:R:N56	R:R:S81	8.94	No	Yes	1	9	9
46	R:R:D84	R:R:N56	5.39	Yes	No	1	9	9
47	R:R:N56	R:R:P299	11.4	No	Yes	1	9	9
48	R:R:S81	R:R:V59	9.7	Yes	No	1	9	8
49	R:R:P299	R:R:V59	3.53	Yes	No	1	9	8
50	R:R:I60	R:R:L85	4.28	No	No	0	7	7
51	R:R:M63	R:R:R70	4.96	No	No	0	6	6
52	R:R:D74	R:R:M63	5.54	No	No	7	8	6
53	R:R:M63	R:R:Y302	4.79	No	Yes	7	6	9
54	R:R:G64	R:R:Y65	4.35	No	No	0	2	5
55	R:R:G64	R:R:L78	3.42	No	No	0	2	5
56	R:R:K67	R:R:R70	3.71	No	No	0	6	6
57	R:R:L78	R:R:R70	3.64	No	No	0	5	6
58	R:R:D74	R:R:S71	8.83	No	No	0	8	7
59	R:R:K75	R:R:M72	8.64	No	Yes	0	6	6
60	R:R:D133	R:R:M72	8.32	No	Yes	0	8	6
61	R:R:A152	R:R:M72	4.83	No	Yes	0	3	6
62	R:R:D74	R:R:Y302	9.2	No	Yes	7	8	9
63	R:R:F129	R:R:Y76	9.28	Yes	Yes	0	5	7
64	R:R:I130	R:R:Y76	4.84	No	Yes	0	8	7
65	R:R:D133	R:R:Y76	3.45	No	Yes	0	8	7
66	R:R:A152	R:R:Y76	4	No	Yes	0	3	7
67	R:R:V156	R:R:Y76	3.79	No	Yes	0	5	7
68	R:R:N298	R:R:R77	13.26	Yes	No	0	9	8
69	R:R:R77	R:R:Y302	31.9	No	Yes	0	8	9
70	R:R:H79	R:R:V156	9.69	Yes	No	8	9	5
71	R:R:H79	R:R:Y157	6.53	Yes	No	8	9	7
72	R:R:H79	R:R:W161	6.35	Yes	Yes	0	9	9
73	R:R:L80	R:R:N298	8.24	No	Yes	0	9	9
74	R:R:N298	R:R:S81	7.45	Yes	Yes	1	9	9
75	R:R:P299	R:R:S81	3.56	Yes	Yes	1	9	9
76	R:R:D84	R:R:N119	6.73	Yes	No	1	9	8
77	R:R:D84	R:R:H294	7.56	Yes	Yes	1	9	9
78	R:R:C295	R:R:D84	10.89	No	Yes	1	9	9
79	R:R:I89	R:R:L85	4.28	No	No	6	4	7
80	R:R:I115	R:R:L86	8.56	No	No	0	5	7
81	R:R:F87	R:R:L91	4.87	Yes	Yes	1	7	8
82	R:R:F87	R:R:W94	4.01	Yes	Yes	1	7	7
83	R:R:F87	R:R:N119	12.08	Yes	No	1	7	8
84	R:R:F292	R:R:F87	12.86	Yes	Yes	1	7	7
85	R:R:C295	R:R:V88	3.42	No	No	0	9	6
86	R:R:I115	R:R:T90	6.08	No	No	0	5	6
87	R:R:L91	R:R:W94	4.56	Yes	Yes	1	8	7
88	R:R:F104	R:R:F93	18.22	Yes	No	1	7	6
89	R:R:F93	R:R:V112	5.24	No	No	0	6	5
90	R:R:W94	R:R:Y116	5.79	Yes	Yes	1	7	6
91	R:R:E288	R:R:W94	5.45	Yes	Yes	1	5	7
92	R:R:F292	R:R:W94	6.01	Yes	Yes	1	7	7
93	R:R:F104	R:R:V96	6.55	Yes	No	0	7	5
94	R:R:D97	R:R:W102	5.58	No	Yes	1	5	9
95	R:R:D97	R:R:R183	3.57	No	Yes	1	5	3
96	R:R:A100	R:R:Y103	4	No	No	0	5	3
97	R:R:N101	R:R:Y103	9.3	No	No	0	4	3
98	R:R:N101	R:R:R183	4.82	No	Yes	0	4	3
99	R:R:N101	R:R:Y184	5.81	No	No	0	4	5
100	R:R:F104	R:R:W102	16.04	Yes	Yes	1	7	9
101	R:R:C109	R:R:W102	3.92	No	Yes	1	9	9
102	R:R:V112	R:R:W102	4.9	No	Yes	0	5	9
103	R:R:V177	R:R:W102	4.9	Yes	Yes	1	4	9
104	R:R:C186	R:R:W102	16.98	No	Yes	1	9	9
105	R:R:N106	R:R:N176	5.45	No	No	0	3	4
106	R:R:N106	R:R:V177	7.39	No	Yes	0	3	4
107	R:R:C109	R:R:V177	3.42	No	Yes	1	9	4
108	R:R:C109	R:R:C186	7.28	No	No	1	9	9
109	R:R:K110	R:R:N176	5.6	No	No	0	7	4
110	R:R:D171	R:R:H113	7.56	No	Yes	1	4	6
111	R:R:A175	R:R:H113	5.85	No	Yes	0	4	6
112	R:R:H113	R:R:R188	11.28	Yes	No	1	6	5
113	R:R:T168	R:R:V114	11.11	No	No	0	6	5
114	R:R:L120	R:R:Y116	11.72	No	Yes	0	7	6
115	R:R:E288	R:R:Y116	5.61	Yes	Yes	1	5	6
116	R:R:T117	R:R:Y121	7.49	Yes	Yes	1	5	7
117	R:R:D171	R:R:T117	8.67	No	Yes	1	4	5
118	R:R:H203	R:R:T117	4.11	No	Yes	1	4	5
119	R:R:H294	R:R:N119	3.83	Yes	No	1	9	8
120	R:R:L120	R:R:W252	5.69	No	Yes	0	7	9
121	R:R:L167	R:R:Y121	5.86	No	Yes	0	5	7
122	R:R:H203	R:R:Y121	10.89	No	Yes	1	4	7
123	R:R:V206	R:R:Y121	11.36	No	Yes	0	4	7
124	R:R:S122	R:R:W161	6.18	No	Yes	0	7	9
125	R:R:F248	R:R:S123	3.96	Yes	No	0	9	9
126	R:R:V124	R:R:W125	3.68	No	No	1	7	5
127	R:R:P211	R:R:V124	10.6	No	No	1	9	7
128	R:R:F248	R:R:V124	5.24	Yes	No	1	9	7
129	R:R:A128	R:R:W125	3.89	No	No	0	7	5
130	R:R:P211	R:R:W125	16.21	No	No	1	9	5
131	R:R:I245	R:R:L127	4.28	No	No	0	7	8
132	R:R:F248	R:R:L127	8.53	Yes	No	0	9	8
133	R:R:F129	R:R:L151	7.31	Yes	No	0	5	4
134	R:R:F129	R:R:V155	3.93	Yes	No	0	5	2
135	R:R:F129	R:R:V160	5.24	Yes	No	0	5	7
136	R:R:I215	R:R:S131	7.74	No	No	0	7	9
137	R:R:C218	R:R:S131	6.89	No	No	0	6	9
138	R:R:S131	R:R:Y219	5.09	No	Yes	0	9	8
139	R:R:L132	R:R:V214	4.47	No	No	0	6	6
140	R:R:C218	R:R:L132	4.76	No	No	0	6	6
141	R:R:D133	R:R:R148	14.29	No	Yes	0	8	6
142	R:R:A137	R:R:R134	4.15	No	Yes	0	8	9
143	R:R:A237	R:R:R134	5.53	No	Yes	0	7	9
144	R:R:L238	R:R:R134	4.86	No	Yes	0	5	9
145	R:R:R134	R:R:T241	7.76	Yes	No	0	9	7
146	R:R:L136	R:R:Y135	4.69	No	Yes	0	5	8
147	R:R:V139	R:R:Y135	7.57	No	Yes	9	7	8
148	R:R:H140	R:R:Y135	9.8	No	Yes	9	6	8
149	R:R:I221	R:R:Y135	7.25	No	Yes	0	4	8
150	R:R:L136	R:R:R148	4.86	No	Yes	0	5	6
151	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
152	R:R:I138	R:R:I222	5.89	Yes	No	0	8	8
153	R:R:I138	R:R:L238	4.28	Yes	No	0	8	5
154	R:R:H140	R:R:V139	5.54	No	No	9	6	7
155	R:R:N143	R:R:T142	7.31	No	No	0	5	5
156	R:R:R148	R:R:S144	6.59	Yes	No	0	6	5
157	R:R:P147	R:R:R146	4.32	No	No	0	4	5
158	R:R:E153	R:R:K149	12.15	No	No	0	7	6
159	R:R:V156	R:R:Y157	5.05	No	No	8	5	7
160	R:R:G159	R:R:P163	4.06	No	No	0	3	4
161	R:R:F199	R:R:P170	7.22	No	No	0	5	8
162	R:R:D171	R:R:R188	8.34	No	No	1	4	5
163	R:R:F174	R:R:I173	8.79	No	No	0	4	3
164	R:R:F174	R:R:Y190	15.47	No	Yes	1	4	4
165	R:R:F174	R:R:W195	8.02	No	Yes	1	4	5
166	R:R:V177	R:R:Y184	3.79	Yes	No	0	4	5
167	R:R:F189	R:R:S178	6.61	No	No	0	3	1
168	R:R:E179	R:R:Y184	4.49	No	No	0	2	5
169	R:R:I185	R:R:R183	6.26	No	Yes	0	3	3
170	R:R:D187	R:R:F189	4.78	No	No	0	3	3
171	R:R:R188	R:R:Y190	8.23	No	Yes	1	5	4
172	R:R:W195	R:R:Y190	10.61	Yes	Yes	1	5	4
173	R:R:F199	R:R:Y190	12.38	No	Yes	1	5	4
174	R:R:P191	R:R:W195	13.51	No	Yes	0	5	5
175	R:R:L194	R:R:N192	8.24	Yes	No	0	2	1
176	R:R:N192	R:R:W195	5.65	No	Yes	0	1	5
177	R:R:N192	S:S:E268	7.89	No	No	0	1	2
178	R:R:D193	R:R:L194	5.43	No	Yes	0	1	2
179	R:R:D193	S:S:L194	5.43	No	Yes	0	1	2
180	R:R:L194	S:S:D193	9.5	Yes	No	0	2	1
181	R:R:L194	S:S:V197	7.45	Yes	No	0	2	3
182	R:R:F199	R:R:W195	6.01	No	Yes	1	5	5
183	R:R:W195	S:S:L267	17.08	Yes	No	1	5	1
184	R:R:W195	S:S:I269	3.52	Yes	No	1	5	1
185	R:R:V197	S:S:L194	7.45	No	Yes	0	3	2
186	R:R:I259	R:R:Q200	4.12	Yes	No	0	5	5
187	R:R:F201	S:S:F201	7.5	No	No	0	4	4
188	R:R:M205	S:S:M205	4.33	No	Yes	0	4	4
189	R:R:L208	R:R:Y256	16.41	No	No	0	8	8
190	R:R:L210	S:S:L210	6.92	No	No	0	6	6
191	R:R:I222	R:R:Y219	3.63	No	Yes	0	8	8
192	R:R:T241	R:R:Y219	4.99	No	Yes	0	7	8
193	R:R:V242	R:R:Y219	5.05	No	Yes	0	4	8
194	R:R:I245	R:R:Y219	3.63	No	Yes	0	7	8
195	R:R:K225	R:R:S224	4.59	No	No	0	4	4
196	R:R:H232	R:R:K230	3.93	No	No	0	4	5
197	R:R:I243	R:R:L301	4.28	No	No	0	5	7
198	R:R:F248	R:R:F249	8.57	Yes	No	0	9	4
199	R:R:F248	R:R:W252	9.02	Yes	Yes	1	9	9
200	R:R:F248	R:R:H294	7.92	Yes	Yes	1	9	9
201	R:R:C251	R:R:L297	4.76	No	No	0	8	6
202	R:R:W252	R:R:Y255	6.75	Yes	Yes	0	9	7
203	R:R:W252	R:R:Y256	10.61	Yes	No	0	9	8
204	R:R:A291	R:R:W252	9.08	No	Yes	0	8	9
205	R:R:H294	R:R:W252	13.75	Yes	Yes	1	9	9
206	R:R:I257	R:R:L253	4.28	No	No	0	6	5
207	R:R:P254	R:R:T287	3.5	No	No	0	9	6
208	R:R:I259	R:R:Y255	13.3	Yes	Yes	0	5	7
209	R:R:T287	R:R:Y255	4.99	No	Yes	0	6	7
210	R:R:E288	R:R:Y255	5.61	Yes	Yes	0	5	7
211	R:R:G258	R:R:I284	3.53	No	No	0	4	4
212	R:R:I261	R:R:V280	6.14	No	No	0	5	5
213	R:R:D262	R:R:V280	4.38	No	No	0	5	5
214	R:R:D262	R:R:I284	5.6	No	No	0	5	4
215	R:R:F264	R:R:I269	12.56	No	No	0	4	1
216	R:R:F264	R:R:I270	3.77	No	No	0	4	5
217	R:R:F276	R:R:I265	3.77	No	No	0	1	3
218	R:R:E277	R:R:I265	9.56	No	No	0	2	3
219	R:R:L266	S:S:L194	4.15	No	Yes	0	3	2
220	R:R:L267	S:S:W195	19.36	No	Yes	0	1	5
221	R:R:E268	R:R:K271	10.8	No	No	0	2	3
222	R:R:E268	S:S:N192	11.83	No	No	0	2	1
223	R:R:F276	R:R:Q272	17.57	No	No	0	1	2
224	R:R:F276	R:R:V280	3.93	No	No	0	1	5
225	R:R:K282	R:R:W283	4.64	No	No	0	2	6
226	R:R:I286	R:R:W283	3.52	No	No	0	6	6
227	R:R:E288	R:R:F292	8.16	Yes	Yes	1	5	7
228	R:R:C295	R:R:H294	8.85	No	Yes	1	9	9
229	R:R:N298	R:R:P299	4.89	Yes	Yes	1	9	9
230	R:R:A303	R:R:F304	4.16	No	No	0	7	6
231	R:R:F304	R:R:F309	9.65	No	No	0	6	8
232	R:R:H315	R:R:S312	6.97	Yes	No	0	4	6
233	R:R:G320	R:R:H315	4.77	No	Yes	10	4	4
234	R:R:E324	R:R:H315	8.62	No	Yes	10	6	4
235	R:R:E324	R:R:G320	4.91	No	No	10	6	4
236	R:R:Q328	R:R:V325	7.16	No	No	0	4	2
237	R:R:F327	R:R:L326	13.4	No	No	0	4	3
238	S:S:C274	S:S:C28	7.28	No	No	0	5	9
239	S:S:E32	S:S:R30	3.49	No	No	0	4	5
240	S:S:N33	S:S:N35	8.17	No	No	0	6	3
241	S:S:A34	S:S:K38	4.82	No	No	0	1	4
242	S:S:F36	S:S:N37	3.62	No	No	0	4	3
243	S:S:F36	S:S:F40	16.08	No	No	0	4	5
244	S:S:L41	S:S:N37	6.87	No	No	0	6	3
245	S:S:K282	S:S:N37	4.2	No	No	0	2	3
246	S:S:F40	S:S:I44	10.05	No	No	0	5	5
247	S:S:F40	S:S:I286	7.54	No	No	0	5	6
248	S:S:L41	S:S:Y45	8.21	No	Yes	0	6	7
249	S:S:P42	S:S:V99	5.3	No	No	0	5	4
250	S:S:L91	S:S:Y45	3.52	Yes	Yes	2	8	7
251	S:S:W94	S:S:Y45	9.65	Yes	Yes	2	7	7
252	S:S:F292	S:S:Y45	4.13	Yes	Yes	2	7	7
253	S:S:F49	S:S:I53	3.77	No	No	0	6	5
254	S:S:F49	S:S:P92	10.11	No	No	0	6	9
255	S:S:G52	S:S:V88	3.68	No	No	0	8	6
256	S:S:I53	S:S:V54	4.61	No	No	0	5	4
257	S:S:G55	S:S:P299	4.06	No	Yes	0	8	9
258	S:S:N56	S:S:S81	8.94	No	Yes	3	9	9
259	S:S:D84	S:S:N56	5.39	Yes	No	3	9	9
260	S:S:N56	S:S:P299	9.77	No	Yes	3	9	9
261	S:S:S81	S:S:V59	8.08	Yes	No	3	9	8
262	S:S:P299	S:S:V59	3.53	Yes	No	3	9	8
263	S:S:V59	S:S:Y302	5.05	No	Yes	3	8	9
264	S:S:I60	S:S:L85	4.28	No	No	0	7	7
265	S:S:K67	S:S:M63	5.76	No	Yes	0	6	6
266	S:S:D74	S:S:M63	4.16	No	Yes	3	8	6
267	S:S:M63	S:S:Y302	3.59	Yes	Yes	3	6	9
268	S:S:K75	S:S:R70	4.95	No	No	0	6	6
269	S:S:L78	S:S:R70	4.86	No	No	0	5	6
270	S:S:D74	S:S:S71	7.36	No	No	0	8	7
271	S:S:K75	S:S:M72	7.2	No	Yes	0	6	6
272	S:S:D133	S:S:M72	9.7	Yes	Yes	4	8	6
273	S:S:M72	S:S:R148	4.96	Yes	Yes	4	6	6
274	S:S:A152	S:S:M72	4.83	No	Yes	0	3	6
275	S:S:D74	S:S:Y302	8.05	No	Yes	3	8	9
276	S:S:E153	S:S:K75	6.75	No	No	0	7	6
277	S:S:F129	S:S:Y76	8.25	Yes	Yes	4	5	7
278	S:S:I130	S:S:Y76	4.84	No	Yes	0	8	7
279	S:S:D133	S:S:Y76	3.45	Yes	Yes	4	8	7
280	S:S:L151	S:S:Y76	3.52	No	Yes	4	4	7
281	S:S:A152	S:S:Y76	5.34	No	Yes	0	3	7
282	S:S:N298	S:S:R77	13.26	Yes	No	3	9	8
283	S:S:R77	S:S:Y302	32.92	No	Yes	3	8	9
284	S:S:H79	S:S:I126	3.98	Yes	No	0	9	7
285	S:S:H79	S:S:V156	9.69	Yes	No	5	9	5
286	S:S:H79	S:S:Y157	6.53	Yes	No	5	9	7
287	S:S:H79	S:S:W161	7.41	Yes	Yes	5	9	9
288	S:S:D84	S:S:L80	5.43	Yes	No	0	9	9
289	S:S:L80	S:S:N298	6.87	No	Yes	0	9	9
290	S:S:N298	S:S:S81	5.96	Yes	Yes	3	9	9
291	S:S:P299	S:S:S81	3.56	Yes	Yes	3	9	9
292	S:S:A83	S:S:S122	3.42	No	Yes	5	8	7
293	S:S:A83	S:S:W161	3.89	No	Yes	5	8	9
294	S:S:D84	S:S:N119	5.39	Yes	No	3	9	8
295	S:S:D84	S:S:H294	5.04	Yes	Yes	3	9	9
296	S:S:C295	S:S:D84	9.34	No	Yes	3	9	9
297	S:S:F87	S:S:L91	8.53	Yes	Yes	0	7	8
298	S:S:F87	S:S:Y116	4.13	Yes	Yes	0	7	6
299	S:S:F87	S:S:N119	15.71	Yes	No	0	7	8
300	S:S:F292	S:S:F87	11.79	Yes	Yes	0	7	7
301	S:S:C295	S:S:V88	3.42	No	No	0	9	6
302	S:S:I115	S:S:T90	9.12	No	No	0	5	6
303	S:S:L91	S:S:W94	5.69	Yes	Yes	2	8	7
304	S:S:F104	S:S:F93	16.08	No	No	0	7	6
305	S:S:F93	S:S:L108	3.65	No	No	0	6	5
306	S:S:F93	S:S:V112	3.93	No	No	0	6	5
307	S:S:W94	S:S:Y116	7.72	Yes	Yes	2	7	6
308	S:S:E288	S:S:W94	4.36	Yes	Yes	2	5	7
309	S:S:F292	S:S:W94	5.01	Yes	Yes	2	7	7
310	S:S:F104	S:S:V96	6.55	No	No	0	7	5
311	S:S:D97	S:S:W102	6.7	No	Yes	2	5	9
312	S:S:D97	S:S:R183	4.76	No	Yes	2	5	3
313	S:S:A100	S:S:Y103	4	No	No	0	5	3
314	S:S:N101	S:S:Y103	10.47	No	No	0	4	3
315	S:S:N101	S:S:R183	7.23	No	Yes	0	4	3
316	S:S:N101	S:S:Y184	5.81	No	No	0	4	5
317	S:S:F104	S:S:W102	11.02	No	Yes	0	7	9
318	S:S:C109	S:S:W102	3.92	No	Yes	2	9	9
319	S:S:V112	S:S:W102	3.68	No	Yes	0	5	9
320	S:S:V177	S:S:W102	3.68	Yes	Yes	2	4	9
321	S:S:C186	S:S:W102	16.98	No	Yes	2	9	9
322	S:S:K110	S:S:N106	4.2	No	No	2	7	3
323	S:S:N106	S:S:N176	8.17	No	No	2	3	4
324	S:S:N106	S:S:V177	4.43	No	Yes	2	3	4
325	S:S:C109	S:S:V177	3.42	No	Yes	2	9	4
326	S:S:C109	S:S:C186	7.28	No	No	2	9	9
327	S:S:K110	S:S:N176	5.6	No	No	2	7	4
328	S:S:D171	S:S:H113	6.3	No	Yes	2	4	6
329	S:S:A175	S:S:H113	5.85	No	Yes	0	4	6
330	S:S:H113	S:S:R188	11.28	Yes	No	2	6	5
331	S:S:T168	S:S:V114	11.11	No	No	0	6	5
332	S:S:L120	S:S:Y116	14.07	No	Yes	0	7	6
333	S:S:E288	S:S:Y116	6.73	Yes	Yes	2	5	6
334	S:S:T117	S:S:Y121	6.24	No	Yes	0	5	7
335	S:S:T117	S:S:T168	6.28	No	No	0	5	6
336	S:S:D171	S:S:T117	10.12	No	No	0	4	5
337	S:S:H294	S:S:N119	5.1	Yes	No	3	9	8
338	S:S:L120	S:S:W252	4.56	No	Yes	0	7	9
339	S:S:L167	S:S:Y121	9.38	No	Yes	11	5	7
340	S:S:H203	S:S:Y121	9.8	No	Yes	0	4	7
341	S:S:V206	S:S:Y121	15.14	No	Yes	11	4	7
342	S:S:S122	S:S:W161	6.18	Yes	Yes	5	7	9
343	S:S:F248	S:S:S123	3.96	Yes	No	0	9	9
344	S:S:V124	S:S:W125	3.68	No	No	3	7	5
345	S:S:P211	S:S:V124	7.07	No	No	3	9	7
346	S:S:F248	S:S:V124	5.24	Yes	No	3	9	7
347	S:S:A128	S:S:W125	3.89	No	No	0	7	5
348	S:S:P211	S:S:W125	16.21	No	No	3	9	5
349	S:S:F248	S:S:L127	9.74	Yes	No	0	9	8
350	S:S:F129	S:S:L151	3.65	Yes	No	4	5	4
351	S:S:F129	S:S:V155	5.24	Yes	No	4	5	2
352	S:S:F129	S:S:V160	5.24	Yes	No	0	5	7
353	S:S:I215	S:S:S131	7.74	No	No	0	7	9
354	S:S:C218	S:S:S131	5.16	No	No	0	6	9
355	S:S:S131	S:S:Y219	3.82	No	No	0	9	8
356	S:S:D133	S:S:R134	3.57	Yes	Yes	0	8	9
357	S:S:D133	S:S:R148	15.48	Yes	Yes	4	8	6
358	S:S:A137	S:S:R134	4.15	No	Yes	0	8	9
359	S:S:I138	S:S:R134	3.76	No	Yes	0	8	9
360	S:S:A237	S:S:R134	4.15	No	Yes	0	7	9
361	S:S:R134	S:S:T241	6.47	Yes	No	0	9	7
362	S:S:L136	S:S:Y135	4.69	No	Yes	0	5	8
363	S:S:V139	S:S:Y135	8.83	No	Yes	12	7	8
364	S:S:H140	S:S:Y135	9.8	No	Yes	12	6	8
365	S:S:I221	S:S:Y135	7.25	No	Yes	0	4	8
366	S:S:L136	S:S:R148	4.86	No	Yes	0	5	6
367	S:S:A137	S:S:R148	6.91	No	Yes	0	8	6
368	S:S:I138	S:S:I222	5.89	No	No	0	8	8
369	S:S:H140	S:S:V139	5.54	No	No	12	6	7
370	S:S:N143	S:S:T142	7.31	No	No	0	5	5
371	S:S:R148	S:S:S144	6.59	Yes	No	0	6	5
372	S:S:K149	S:S:Q145	4.07	No	No	0	6	5
373	S:S:P147	S:S:R146	4.32	No	No	0	4	5
374	S:S:E153	S:S:K149	8.1	No	No	0	7	6
375	S:S:K154	S:S:L150	4.23	No	No	0	3	4
376	S:S:L151	S:S:V155	4.47	No	No	4	4	2
377	S:S:V156	S:S:Y157	5.05	No	No	5	5	7
378	S:S:L167	S:S:V206	4.47	No	No	11	5	4
379	S:S:F199	S:S:P170	5.78	Yes	No	0	5	8
380	S:S:D171	S:S:R188	8.34	No	No	2	4	5
381	S:S:F174	S:S:I173	8.79	Yes	No	0	4	3
382	S:S:F174	S:S:Y190	13.41	Yes	Yes	2	4	4
383	S:S:F174	S:S:W195	8.02	Yes	Yes	2	4	5
384	S:S:F174	S:S:F199	4.29	Yes	Yes	2	4	5
385	S:S:V177	S:S:Y184	3.79	Yes	No	0	4	5
386	S:S:E179	S:S:Y184	6.73	No	No	0	2	5
387	S:S:I185	S:S:R183	6.26	No	Yes	0	3	3
388	S:S:D187	S:S:F189	3.58	No	No	0	3	3
389	S:S:R188	S:S:Y190	10.29	No	Yes	2	5	4
390	S:S:W195	S:S:Y190	10.61	Yes	Yes	2	5	4
391	S:S:F199	S:S:Y190	11.35	Yes	Yes	2	5	4
392	S:S:P191	S:S:W195	13.51	No	Yes	0	5	5
393	S:S:L194	S:S:N192	5.49	Yes	No	0	2	1
394	S:S:N192	S:S:W195	5.65	No	Yes	0	1	5
395	S:S:F199	S:S:W195	5.01	Yes	Yes	2	5	5
396	S:S:F199	S:S:Q202	3.51	Yes	No	0	5	3
397	S:S:I204	S:S:Q200	8.23	No	No	0	5	5
398	S:S:I259	S:S:Q200	5.49	Yes	No	0	5	5
399	S:S:I209	S:S:M205	5.83	No	Yes	0	4	4
400	S:S:L208	S:S:Y256	18.76	No	No	0	8	8
401	S:S:V242	S:S:Y219	3.79	No	No	0	4	8
402	S:S:I245	S:S:Y219	3.63	No	No	0	7	8
403	S:S:K230	S:S:Q233	8.14	No	No	0	5	5
404	S:S:H232	S:S:K236	5.24	No	No	0	4	8
405	S:S:I243	S:S:L301	4.28	No	No	0	5	7
406	S:S:L244	S:S:L301	5.54	No	No	0	7	7
407	S:S:F248	S:S:F249	9.65	Yes	No	0	9	4
408	S:S:F248	S:S:W252	10.02	Yes	Yes	3	9	9
409	S:S:F248	S:S:H294	6.79	Yes	Yes	3	9	9
410	S:S:C251	S:S:L297	4.76	No	No	0	8	6
411	S:S:W252	S:S:Y255	7.72	Yes	Yes	0	9	7
412	S:S:W252	S:S:Y256	12.54	Yes	No	0	9	8
413	S:S:A291	S:S:W252	7.78	No	Yes	0	8	9
414	S:S:H294	S:S:W252	10.58	Yes	Yes	3	9	9
415	S:S:I257	S:S:L253	4.28	No	No	0	6	5
416	S:S:P254	S:S:T287	3.5	No	No	0	9	6
417	S:S:I259	S:S:Y255	10.88	Yes	Yes	0	5	7
418	S:S:T287	S:S:Y255	4.99	No	Yes	0	6	7
419	S:S:E288	S:S:Y255	8.98	Yes	Yes	0	5	7
420	S:S:G258	S:S:I284	3.53	No	No	0	4	4
421	S:S:I259	S:S:I284	5.89	Yes	No	0	5	4
422	S:S:I261	S:S:V280	4.61	No	Yes	0	5	5
423	S:S:D262	S:S:V280	4.38	No	Yes	0	5	5
424	S:S:D262	S:S:H281	11.35	No	No	0	5	4
425	S:S:D262	S:S:I284	4.2	No	No	0	5	4
426	S:S:F264	S:S:I269	13.82	No	No	0	4	1
427	S:S:F264	S:S:I270	3.77	No	No	0	4	5
428	S:S:F276	S:S:I265	3.77	No	No	13	1	3
429	S:S:E277	S:S:I265	8.2	No	No	0	2	3
430	S:S:I265	S:S:V280	4.61	No	Yes	13	3	5
431	S:S:I269	S:S:L267	4.28	No	No	1	1	1
432	S:S:E268	S:S:K271	12.15	No	No	0	2	3
433	S:S:F276	S:S:Q272	15.23	No	No	0	1	2
434	S:S:F276	S:S:V280	3.93	No	Yes	13	1	5
435	S:S:K282	S:S:W283	6.96	No	No	0	2	6
436	S:S:I286	S:S:W283	8.22	No	No	0	6	6
437	S:S:E288	S:S:F292	7	Yes	Yes	2	5	7
438	S:S:C296	S:S:F293	5.59	No	No	0	7	5
439	S:S:C295	S:S:H294	7.37	No	Yes	3	9	9
440	S:S:N298	S:S:P299	6.52	Yes	Yes	3	9	9
441	S:S:N298	S:S:Y302	4.65	Yes	Yes	3	9	9
442	S:S:A303	S:S:F304	4.16	No	No	0	7	6
443	S:S:F304	S:S:F309	9.65	No	No	14	6	8
444	R:R:I162	R:R:P163	3.39	No	No	0	4	4
445	R:R:I169	R:R:P170	3.39	No	No	0	3	8
446	S:S:I162	S:S:P163	3.39	No	No	0	4	4
447	S:S:I169	S:S:P170	3.39	No	No	0	3	8
448	R:R:Q202	R:R:Y121	3.38	No	Yes	0	3	7
449	S:S:C296	S:S:T51	3.38	No	No	0	7	5
450	R:R:L253	R:R:P254	3.28	No	No	0	5	9
451	S:S:L253	S:S:P254	3.28	No	No	0	5	9
452	R:R:C296	R:R:I48	3.27	No	No	0	7	7
453	R:R:A289	R:R:I44	3.25	No	No	0	4	5
454	S:S:A289	S:S:I44	3.25	No	No	0	4	5
455	S:S:V156	S:S:V160	3.21	No	No	0	5	7
456	S:S:C218	S:S:L132	3.17	No	No	0	6	6
457	R:R:A247	R:R:L297	3.15	No	No	0	6	6
458	S:S:A247	S:S:L297	3.15	No	No	0	6	6
459	R:R:T241	R:R:T73	3.14	No	No	0	7	7
460	R:R:T117	R:R:T168	3.14	Yes	No	0	5	6
461	S:S:T241	S:S:T73	3.14	No	No	0	7	7
462	R:R:I138	R:R:S229	3.1	Yes	No	0	8	5
463	R:R:I60	R:R:V82	3.07	No	No	0	7	5
464	S:S:I60	S:S:V82	3.07	No	No	0	7	5
465	R:R:I47	R:R:T51	3.04	No	No	0	4	5
466	R:R:K225	R:R:V139	3.04	No	No	0	4	7
467	R:R:K282	R:R:T279	3	No	No	0	2	2
468	S:S:L41	S:S:S285	3	No	No	0	6	5
469	S:S:L165	S:S:V118	2.98	No	No	0	3	5
470	S:S:L132	S:S:V214	2.98	No	No	0	6	6
471	S:S:L246	S:S:V242	2.98	No	No	0	5	4
472	S:S:C251	S:S:H294	2.95	No	Yes	0	8	9
473	R:R:I204	R:R:I209	2.94	No	No	0	5	4
474	R:R:I209	R:R:I213	2.94	No	No	0	4	3
475	R:R:I259	R:R:I284	2.94	Yes	No	0	5	4
476	R:R:I265	R:R:I270	2.94	No	No	0	3	5
477	S:S:I204	S:S:I209	2.94	No	No	0	5	4
478	R:R:G207	R:R:Y121	2.9	No	Yes	0	5	7
479	S:S:G207	S:S:Y121	2.9	No	Yes	0	5	7
480	R:R:F29	R:R:P27	2.89	No	No	0	4	5
481	R:R:Q314	R:R:S312	2.89	No	No	0	5	6
482	S:S:Q314	S:S:S312	2.89	No	No	0	5	6
483	S:S:K308	S:S:K310	2.87	No	No	0	6	8
484	R:R:I48	R:R:L91	2.85	No	Yes	0	7	8
485	R:R:I138	R:R:L226	2.85	Yes	No	0	8	8
486	R:R:I162	R:R:L166	2.85	No	No	0	4	4
487	S:S:I44	S:S:L290	2.85	No	No	0	5	7
488	S:S:I48	S:S:L91	2.85	No	Yes	0	7	8
489	S:S:I53	S:S:L85	2.85	No	No	0	5	7
490	S:S:I89	S:S:L85	2.85	No	No	0	4	7
491	S:S:I245	S:S:L127	2.85	No	No	0	7	8
492	S:S:I138	S:S:L238	2.85	No	No	0	8	5
493	S:S:I162	S:S:L166	2.85	No	No	0	4	4
494	S:S:I222	S:S:L226	2.85	No	No	0	8	8
495	S:S:I286	S:S:L290	2.85	No	No	0	6	7
496	R:R:L210	R:R:M205	2.83	No	No	0	6	4
497	S:S:L78	S:S:M63	2.83	No	Yes	0	5	6
498	S:S:L210	S:S:M205	2.83	No	Yes	0	6	4
499	R:R:G105	R:R:W102	2.81	No	Yes	0	8	9
500	R:R:K282	R:R:N37	2.8	No	No	0	2	3
501	S:S:K282	S:S:N33	2.8	No	No	0	2	6
502	S:S:C251	S:S:F293	2.79	No	No	0	8	5
503	R:R:L244	R:R:L80	2.77	No	No	0	7	9
504	R:R:L127	R:R:L244	2.77	No	No	0	8	7
505	R:R:L244	R:R:L301	2.77	No	No	0	7	7
506	R:R:A307	R:R:F304	2.77	No	No	0	5	6
507	S:S:L127	S:S:L244	2.77	No	No	0	8	7
508	S:S:A307	S:S:F304	2.77	No	No	14	5	6
509	S:S:A307	S:S:F309	2.77	No	No	14	5	8
510	R:R:I204	R:R:Q200	2.74	No	No	0	5	5
511	R:R:H315	R:R:T311	2.74	Yes	No	0	4	4
512	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
513	S:S:A95	S:S:Y45	2.67	No	Yes	0	7	7
514	R:R:H79	R:R:I126	2.65	Yes	No	0	9	7
515	S:S:F189	S:S:S178	2.64	No	No	0	3	1
516	S:S:E31	S:S:N278	2.63	No	No	0	5	3
517	R:R:V198	S:S:F201	2.62	No	No	0	3	4
518	R:R:F201	S:S:V198	2.62	No	No	0	4	3
519	S:S:F172	S:S:V114	2.62	No	No	0	4	5
520	R:R:A83	R:R:W161	2.59	No	Yes	0	8	9
521	R:R:F87	R:R:T90	2.59	Yes	No	0	7	6
522	S:S:R77	S:S:T240	2.59	No	No	0	8	7
523	S:S:F87	S:S:T90	2.59	Yes	No	0	7	6
524	R:R:V196	R:R:Y190	2.52	No	Yes	0	4	4
525	S:S:V196	S:S:Y190	2.52	No	Yes	0	4	4
526	S:S:F293	S:S:I300	2.51	No	No	0	5	6
527	R:R:F201	R:R:M205	2.49	No	No	0	4	4
528	S:S:F201	S:S:M205	2.49	No	Yes	0	4	4
529	R:R:F172	R:R:K110	2.48	No	No	0	4	7
530	R:R:V118	R:R:W161	2.45	No	Yes	0	5	9
531	S:S:V82	S:S:W161	2.45	No	Yes	0	5	9
532	R:R:F93	R:R:L108	2.44	No	Yes	1	6	5
533	R:R:F104	R:R:L108	2.44	Yes	Yes	1	7	5
534	R:R:F107	R:R:L108	2.44	No	Yes	0	1	5
535	S:S:T279	S:S:W283	2.43	No	No	0	2	6
536	S:S:D181	S:S:R30	2.38	No	No	0	2	5
537	R:R:L305	R:R:Y302	2.34	No	Yes	0	6	9
538	S:S:L61	S:S:Y65	2.34	No	No	0	4	5
539	S:S:G159	S:S:P163	2.03	No	No	0	3	4
540	M:M:?1	S:S:E32	2	Yes	No	0	0	4
541	R:R:A95	R:R:P42	1.87	No	No	0	7	5
542	R:R:A98	R:R:P42	1.87	No	No	0	5	5
543	S:S:A95	S:S:P42	1.87	No	No	0	7	5
544	S:S:A98	S:S:P42	1.87	No	No	0	5	5
545	R:R:G55	R:R:V54	1.84	No	No	0	8	4
546	R:R:G159	R:R:V158	1.84	No	No	0	3	4
547	S:S:G159	S:S:V158	1.84	No	No	0	3	4
548	R:R:G52	R:R:T51	1.82	No	No	0	8	5
549	R:R:G320	R:R:T318	1.82	No	No	0	4	4
550	R:R:G57	R:R:I60	1.76	No	No	0	3	7
551	S:S:G57	S:S:I60	1.76	No	No	0	3	7
552	S:S:G64	S:S:M63	1.75	No	Yes	0	2	6
553	R:R:G231	R:R:K234	1.74	No	No	0	4	7
554	S:S:G231	S:S:K234	1.74	No	No	0	4	7
555	R:R:A95	R:R:S46	1.71	No	No	0	7	5
556	S:S:A95	S:S:S46	1.71	No	No	0	7	5
557	S:S:A164	S:S:S122	1.71	No	Yes	0	7	7
558	R:R:L136	R:R:P147	1.64	No	No	0	5	4
559	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
560	R:R:C296	R:R:I300	1.64	No	No	0	7	6
561	S:S:L136	S:S:P147	1.64	No	No	0	5	4
562	S:S:G273	S:S:Q272	1.64	No	No	0	5	2
563	S:S:S224	S:S:S227	1.63	No	No	0	4	4
564	R:R:A180	R:R:I185	1.62	No	No	0	1	3
565	S:S:S122	S:S:V118	1.62	Yes	No	0	7	5
566	S:S:A180	S:S:I185	1.62	No	No	0	1	3
567	R:R:A111	R:R:L108	1.58	No	Yes	0	4	5
568	S:S:A111	S:S:L108	1.58	No	No	0	4	5
569	R:R:A34	R:R:N33	1.56	No	No	0	1	6
570	R:R:I213	R:R:S217	1.55	No	No	0	3	3
571	R:R:I259	R:R:S263	1.55	Yes	No	0	5	5
572	S:S:I213	S:S:S217	1.55	No	No	0	3	3
573	S:S:I223	S:S:S224	1.55	No	No	0	4	4
574	S:S:I259	S:S:S263	1.55	Yes	No	0	5	5
575	R:R:C28	R:R:E277	1.52	No	No	0	9	2
576	R:R:I39	R:R:T43	1.52	No	No	0	5	4
577	R:R:I47	R:R:T43	1.52	No	No	0	4	4
578	R:R:K67	R:R:V62	1.52	No	No	0	6	7
579	S:S:C28	S:S:E277	1.52	No	No	0	9	2
580	S:S:I39	S:S:T43	1.52	No	No	0	5	4
581	S:S:I47	S:S:T43	1.52	No	No	0	4	4
582	S:S:I47	S:S:T51	1.52	No	No	0	4	5
583	S:S:K225	S:S:V139	1.52	No	No	0	4	7
584	S:S:K154	S:S:V155	1.52	No	No	0	3	2
585	S:S:F129	S:S:G159	1.51	Yes	No	0	5	3
586	R:R:L58	R:R:V54	1.49	No	No	0	5	4
587	R:R:L58	R:R:V62	1.49	No	No	0	5	7
588	R:R:L246	R:R:V242	1.49	No	No	0	5	4
589	S:S:L58	S:S:V54	1.49	No	No	0	5	4
590	S:S:L58	S:S:V62	1.49	No	No	0	5	7
591	S:S:L86	S:S:V118	1.49	No	No	0	7	5
592	R:R:C251	R:R:H294	1.47	No	Yes	0	8	9
593	R:R:L317	R:R:T318	1.47	No	No	0	5	4
594	S:S:I209	S:S:I213	1.47	No	No	0	4	3
595	S:S:L317	S:S:T318	1.47	No	No	0	5	4
596	R:R:I243	R:R:K239	1.45	No	No	0	5	6
597	S:S:I243	S:S:K239	1.45	No	No	0	5	6
598	R:R:K149	R:R:M72	1.44	No	Yes	0	6	6
599	R:R:K308	R:R:K310	1.44	No	No	0	6	8
600	R:R:P322	R:R:R321	1.44	No	No	0	2	4
601	S:S:Q233	S:S:S71	1.44	No	No	0	5	7
602	S:S:K230	S:S:K234	1.44	No	No	0	5	7
603	R:R:I44	R:R:L290	1.43	No	No	0	5	7
604	R:R:Q66	R:R:V62	1.43	No	No	0	4	7
605	R:R:I169	R:R:L166	1.43	No	No	0	3	4
606	R:R:I286	R:R:L290	1.43	No	No	0	6	7
607	S:S:Q314	S:S:T318	1.42	No	No	0	5	4
608	R:R:K154	R:R:L150	1.41	No	No	0	3	4
609	S:S:G105	S:S:W102	1.41	No	Yes	0	8	9
610	R:R:H228	R:R:S227	1.39	No	No	0	5	4
611	S:S:A111	S:S:F107	1.39	No	No	0	4	1
612	S:S:H228	S:S:S227	1.39	No	No	0	5	4
613	S:S:H315	S:S:S312	1.39	No	No	0	4	6
614	R:R:L194	S:S:L266	1.38	Yes	No	0	2	3
615	R:R:L323	R:R:L326	1.38	No	No	0	3	3
616	S:S:H315	S:S:T311	1.37	No	No	0	4	4
617	R:R:K149	R:R:Q145	1.36	No	No	0	6	5
618	R:R:K230	R:R:Q233	1.36	No	No	0	5	5
619	S:S:K67	S:S:Q66	1.36	No	No	0	6	4
620	R:R:E153	R:R:K154	1.35	No	No	0	7	3
621	R:R:A164	R:R:Y121	1.33	No	Yes	0	7	7
622	R:R:R77	R:R:T240	1.29	No	No	0	8	7
623	S:S:F49	S:S:L50	1.22	No	No	0	6	5
624	R:R:N278	R:R:R30	1.21	No	No	0	3	5
625	S:S:L305	S:S:Y302	1.17	No	Yes	0	6	9
626	R:R:H232	R:R:R235	1.13	No	No	0	4	5
627	S:S:H232	S:S:R235	1.13	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.61889	9	1	0
2	M:M:?1	8.8	10	2	0
3	R:R:Y45	6.338	5	1	7
4	R:R:I53	6.3625	4	6	5
5	R:R:M72	5.8075	4	0	6
6	R:R:Y76	5.072	5	0	7
7	R:R:H79	6.305	4	8	9
8	R:R:S81	7.4125	4	1	9
9	R:R:D84	7.6425	4	1	9
10	R:R:F87	7.282	5	1	7
11	R:R:L91	4.2425	4	1	8
12	R:R:W94	7.40286	7	1	7
13	R:R:W102	7.87571	7	1	9
14	R:R:F104	10.8125	4	1	7
15	R:R:L108	2.225	4	1	5
16	R:R:H113	7.145	4	1	6
17	R:R:Y116	8.88	4	1	6
18	R:R:T117	5.8525	4	1	5
19	R:R:Y121	6.17286	7	1	7
20	R:R:F129	6.44	4	0	5
21	R:R:R134	5.575	4	0	9
22	R:R:Y135	7.3275	4	9	8
23	R:R:I138	4.03	4	0	8
24	R:R:R148	8.1625	4	0	6
25	R:R:W161	4.3925	4	0	9
26	R:R:V177	4.875	4	1	4
27	R:R:R183	5.27	4	1	3
28	R:R:Y190	9.842	5	1	4
29	R:R:L194	6.4	5	0	2
30	R:R:W195	9.2	7	1	5
31	R:R:Y219	4.478	5	0	8
32	R:R:F248	7.20667	6	1	9
33	R:R:W252	9.15	6	1	9
34	R:R:Y255	7.6625	4	0	7
35	R:R:I259	5.4775	4	0	5
36	R:R:E288	7.17	5	1	5
37	R:R:F292	7.79	4	1	7
38	R:R:H294	7.23	6	1	9
39	R:R:N298	8.46	4	1	9
40	R:R:P299	5.488	5	1	9
41	R:R:Y302	12.0575	4	7	9
42	R:R:H315	5.775	4	10	4
43	S:S:Y45	5.636	5	2	7
44	S:S:M63	3.618	5	3	6
45	S:S:M72	6.6725	4	4	6
46	S:S:Y76	5.08	5	4	7
47	S:S:H79	6.9025	4	5	9
48	S:S:S81	6.635	4	3	9
49	S:S:D84	6.118	5	3	9
50	S:S:F87	8.55	5	0	7
51	S:S:L91	5.1475	4	2	8
52	S:S:W94	8.56167	6	2	7
53	S:S:W102	6.35375	8	2	9
54	S:S:H113	7.0725	4	2	6
55	S:S:Y116	8.124	5	2	6
56	S:S:Y121	8.692	5	11	7
57	S:S:S122	3.2325	4	5	7
58	S:S:F129	4.778	5	4	5
59	S:S:D133	8.05	4	4	8
60	S:S:R134	4.42	5	0	9
61	S:S:Y135	7.6425	4	12	8
62	S:S:R148	7.76	5	4	6
63	S:S:W161	4.9825	4	5	9
64	S:S:F174	8.6275	4	2	4
65	S:S:V177	3.83	4	2	4
66	S:S:R183	6.17	4	2	3
67	S:S:Y190	9.636	5	2	4
68	S:S:L194	5.63	4	0	2
69	S:S:W195	10.36	6	2	5
70	S:S:F199	5.988	5	2	5
71	S:S:M205	3.87	4	0	4
72	S:S:F248	7.56667	6	3	9
73	S:S:W252	8.86667	6	3	9
74	S:S:Y255	8.1425	4	0	7
75	S:S:I259	5.9525	4	0	5
76	S:S:V280	4.3825	4	13	5
77	S:S:E288	7.618	5	2	5
78	S:S:F292	6.9825	4	2	7
79	S:S:H294	6.305	6	3	9
80	S:S:N298	7.452	5	3	9
81	S:S:P299	5.488	5	3	9
82	S:S:Y302	9.23833	6	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H113	99.8895	3.89	Yes	Yes	1	0	6
2	R:R:H113	R:R:R188	97.1801	11.28	Yes	No	1	6	5
3	R:R:R188	R:R:Y190	100	8.23	No	Yes	1	5	4
4	R:R:W195	R:R:Y190	97.4109	10.61	Yes	Yes	1	5	4
5	R:R:N192	R:R:W195	99.7633	5.65	No	Yes	0	1	5
6	R:R:L194	R:R:N192	99.6824	8.24	Yes	No	0	2	1
7	R:R:D193	R:R:L194	99.5562	5.43	No	Yes	0	1	2
8	R:R:D193	S:S:L194	99.5214	5.43	No	Yes	0	1	2
9	S:S:L194	S:S:N192	99.4089	5.49	Yes	No	0	2	1
10	S:S:N192	S:S:W195	99.2847	5.65	No	Yes	0	1	5
11	S:S:W195	S:S:Y190	97.4681	10.61	Yes	Yes	2	5	4
12	S:S:R188	S:S:Y190	98.7278	10.29	No	Yes	2	5	4
13	S:S:H113	S:S:R188	95.8093	11.28	Yes	No	2	6	5
14	M:M:?1	S:S:H113	97.8645	4.86	Yes	Yes	2	0	6
15	M:M:?1	S:S:Y116	60.9042	7.97	Yes	Yes	2	0	6
16	M:M:?1	S:S:E288	24.5526	11.02	Yes	Yes	2	0	5
17	L:L:?1	R:R:E288	36.3555	11.02	Yes	Yes	1	0	5
18	R:R:E288	R:R:Y255	39.3805	5.61	Yes	Yes	0	5	7
19	L:L:?1	R:R:W94	32.4495	16.35	Yes	Yes	1	0	7
20	R:R:W94	R:R:Y45	12.2914	9.65	Yes	Yes	1	7	7
21	R:R:L41	R:R:Y45	14.0232	10.55	No	Yes	0	6	7
22	R:R:L41	R:R:N37	12.486	5.49	No	No	0	6	3
23	R:R:F87	R:R:W94	25.6788	4.01	Yes	Yes	1	7	7
24	R:R:F87	R:R:N119	29.8334	12.08	Yes	No	1	7	8
25	R:R:D84	R:R:N119	18.6768	6.73	Yes	No	1	9	8
26	R:R:C295	R:R:V88	21.114	3.42	No	No	0	9	6
27	R:R:I53	R:R:V88	12.7037	6.14	Yes	No	0	5	6
28	R:R:H294	R:R:N119	10.9134	3.83	Yes	No	1	9	8
29	R:R:C295	R:R:H294	16.4203	8.85	No	Yes	1	9	9
30	L:L:?1	R:R:Y116	28.243	12.4	Yes	Yes	1	0	6
31	R:R:L120	R:R:Y116	29.2561	11.72	No	Yes	0	7	6
32	R:R:L120	R:R:W252	29.0411	5.69	No	Yes	0	7	9
33	R:R:H294	R:R:W252	13.3144	13.75	Yes	Yes	1	9	9
34	R:R:W252	R:R:Y255	32.6349	6.75	Yes	Yes	0	9	7
35	R:R:D84	R:R:N56	14.0035	5.39	Yes	No	1	9	9
36	R:R:F248	R:R:W252	46.0039	9.02	Yes	Yes	1	9	9
37	R:R:F248	R:R:L127	45.8836	8.53	Yes	No	0	9	8
38	R:R:I245	R:R:L127	42.0906	4.28	No	No	0	7	8
39	R:R:I245	R:R:Y219	41.3608	3.63	No	Yes	0	7	8
40	R:R:T241	R:R:Y219	31.6493	4.99	No	Yes	0	7	8
41	R:R:R134	R:R:T241	30.1569	7.76	Yes	No	0	9	7
42	R:R:A137	R:R:R134	27.9997	4.15	No	Yes	0	8	9
43	R:R:A137	R:R:R148	27.2449	6.91	No	Yes	0	8	6
44	R:R:D133	R:R:R148	18.8556	14.29	No	Yes	0	8	6
45	R:R:D133	R:R:Y76	11.8588	3.45	No	Yes	0	8	7
46	L:L:?1	R:R:C186	10.6228	4.8	Yes	No	1	0	9
47	S:S:E288	S:S:Y255	26.2015	8.98	Yes	Yes	0	5	7
48	S:S:I259	S:S:Y255	14.6333	10.88	Yes	Yes	0	5	7
49	S:S:L41	S:S:Y45	11.0422	8.21	No	Yes	0	6	7
50	S:S:F87	S:S:Y116	48.2058	4.13	Yes	Yes	0	7	6
51	S:S:F87	S:S:N119	53.1887	15.71	Yes	No	0	7	8
52	S:S:D84	S:S:N119	47.2071	5.39	Yes	No	3	9	8
53	S:S:D84	S:S:L80	49.8915	5.43	Yes	No	0	9	9
54	S:S:L80	S:S:N298	49.5654	6.87	No	Yes	0	9	9
55	S:S:N298	S:S:Y302	48.7995	4.65	Yes	Yes	3	9	9
56	S:S:M63	S:S:Y302	46.213	3.59	Yes	Yes	3	6	9
57	S:S:L78	S:S:M63	45.2294	2.83	No	Yes	0	5	6
58	S:S:L78	S:S:R70	44.8717	4.86	No	No	0	5	6
59	S:S:K75	S:S:R70	44.5127	4.95	No	No	0	6	6
60	S:S:K75	S:S:M72	43.0637	7.2	No	Yes	0	6	6
61	S:S:D133	S:S:M72	20.7077	9.7	Yes	Yes	4	8	6
62	S:S:D133	S:S:Y76	17.3645	3.45	Yes	Yes	4	8	7
63	S:S:F129	S:S:Y76	28.9859	8.25	Yes	Yes	4	5	7
64	S:S:F129	S:S:V160	21.2383	5.24	Yes	No	0	5	7
65	S:S:V156	S:S:V160	20.3684	3.21	No	No	0	5	7
66	S:S:H79	S:S:V156	18.611	9.69	Yes	No	5	9	5
67	S:S:H79	S:S:W161	16.876	7.41	Yes	Yes	5	9	9
68	S:S:V82	S:S:W161	10.7135	2.45	No	Yes	0	5	9
69	S:S:A152	S:S:M72	17.2645	4.83	No	Yes	0	3	6
70	S:S:A152	S:S:Y76	16.8516	5.34	No	Yes	0	3	7
71	S:S:L120	S:S:Y116	13.2263	14.07	No	Yes	0	7	6
72	S:S:L120	S:S:W252	13.0179	4.56	No	Yes	0	7	9
73	S:S:H294	S:S:W252	12.9443	10.58	Yes	Yes	3	9	9
74	S:S:W252	S:S:Y255	17.373	7.72	Yes	Yes	0	9	7
75	S:S:F248	S:S:W252	14.9798	10.02	Yes	Yes	3	9	9
76	S:S:F248	S:S:L127	11.8549	9.74	Yes	No	0	9	8
77	S:S:C251	S:S:H294	11.2487	2.95	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:W94	18.94	2	Yes	Yes	0	7	0	1
M:M:?1	S:S:D97	22.56	2	Yes	No	0	5	0	1
M:M:?1	S:S:W102	3.44	2	Yes	Yes	0	9	0	1
M:M:?1	S:S:H113	4.86	2	Yes	Yes	0	6	0	1
M:M:?1	S:S:Y116	7.97	2	Yes	Yes	0	6	0	1
M:M:?1	S:S:R183	6.43	2	Yes	Yes	0	3	0	1
M:M:?1	S:S:C186	3.6	2	Yes	No	0	9	0	1
M:M:?1	S:S:D187	7.18	2	Yes	No	0	3	0	1
M:M:?1	S:S:E288	11.02	2	Yes	Yes	0	5	0	1
S:S:E32	S:S:R30	3.49	0	No	No	4	5	1	2
S:S:L91	S:S:Y45	3.52	2	Yes	Yes	8	7	2	2
S:S:W94	S:S:Y45	9.65	2	Yes	Yes	7	7	1	2
S:S:F292	S:S:Y45	4.13	2	Yes	Yes	7	7	2	2
S:S:F87	S:S:L91	8.53	0	Yes	Yes	7	8	2	2
S:S:F87	S:S:Y116	4.13	0	Yes	Yes	7	6	2	1
S:S:F292	S:S:F87	11.79	2	Yes	Yes	7	7	2	2
S:S:L91	S:S:W94	5.69	2	Yes	Yes	8	7	2	1
S:S:W94	S:S:Y116	7.72	2	Yes	Yes	7	6	1	1
S:S:E288	S:S:W94	4.36	2	Yes	Yes	5	7	1	1
S:S:F292	S:S:W94	5.01	2	Yes	Yes	7	7	2	1
S:S:D97	S:S:W102	6.7	2	No	Yes	5	9	1	1
S:S:D97	S:S:R183	4.76	2	No	Yes	5	3	1	1
S:S:N101	S:S:R183	7.23	0	No	Yes	4	3	2	1
S:S:F104	S:S:W102	11.02	0	No	Yes	7	9	2	1
S:S:C109	S:S:W102	3.92	2	No	Yes	9	9	2	1
S:S:V112	S:S:W102	3.68	0	No	Yes	5	9	2	1
S:S:V177	S:S:W102	3.68	2	Yes	Yes	4	9	2	1
S:S:C186	S:S:W102	16.98	2	No	Yes	9	9	1	1
S:S:C109	S:S:V177	3.42	2	No	Yes	9	4	2	2
S:S:C109	S:S:C186	7.28	2	No	No	9	9	2	1
S:S:D171	S:S:H113	6.3	2	No	Yes	4	6	2	1
S:S:A175	S:S:H113	5.85	0	No	Yes	4	6	2	1
S:S:H113	S:S:R188	11.28	2	Yes	No	6	5	1	2
S:S:L120	S:S:Y116	14.07	0	No	Yes	7	6	2	1
S:S:E288	S:S:Y116	6.73	2	Yes	Yes	5	6	1	1
S:S:D171	S:S:R188	8.34	2	No	No	4	5	2	2
S:S:I185	S:S:R183	6.26	0	No	Yes	3	3	2	1
S:S:D187	S:S:F189	3.58	0	No	No	3	3	1	2
S:S:E288	S:S:Y255	8.98	2	Yes	Yes	5	7	1	2
S:S:E288	S:S:F292	7	2	Yes	Yes	5	7	1	2
M:M:?1	S:S:E32	2	2	Yes	No	0	4	0	1
S:S:G105	S:S:W102	1.41	0	No	Yes	8	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:E32	5.01	1	Yes	No	0	4	0	1
L:L:?1	R:R:W94	16.35	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:D97	19.49	1	Yes	No	0	5	0	1
L:L:?1	R:R:H113	3.89	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y116	12.4	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R183	6.43	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:C186	4.8	1	Yes	No	0	9	0	1
L:L:?1	R:R:D187	7.18	1	Yes	No	0	3	0	1
L:L:?1	R:R:E288	11.02	1	Yes	Yes	0	5	0	1
R:R:E32	R:R:R30	3.49	0	No	No	4	5	1	2
R:R:L91	R:R:Y45	4.69	1	Yes	Yes	8	7	2	2
R:R:W94	R:R:Y45	9.65	1	Yes	Yes	7	7	1	2
R:R:F292	R:R:Y45	4.13	1	Yes	Yes	7	7	2	2
R:R:F87	R:R:L91	4.87	1	Yes	Yes	7	8	2	2
R:R:F87	R:R:W94	4.01	1	Yes	Yes	7	7	2	1
R:R:F292	R:R:F87	12.86	1	Yes	Yes	7	7	2	2
R:R:L91	R:R:W94	4.56	1	Yes	Yes	8	7	2	1
R:R:W94	R:R:Y116	5.79	1	Yes	Yes	7	6	1	1
R:R:E288	R:R:W94	5.45	1	Yes	Yes	5	7	1	1
R:R:F292	R:R:W94	6.01	1	Yes	Yes	7	7	2	1
R:R:D97	R:R:W102	5.58	1	No	Yes	5	9	1	2
R:R:D97	R:R:R183	3.57	1	No	Yes	5	3	1	1
R:R:N101	R:R:R183	4.82	0	No	Yes	4	3	2	1
R:R:C109	R:R:W102	3.92	1	No	Yes	9	9	2	2
R:R:C186	R:R:W102	16.98	1	No	Yes	9	9	1	2
R:R:C109	R:R:C186	7.28	1	No	No	9	9	2	1
R:R:D171	R:R:H113	7.56	1	No	Yes	4	6	2	1
R:R:A175	R:R:H113	5.85	0	No	Yes	4	6	2	1
R:R:H113	R:R:R188	11.28	1	Yes	No	6	5	1	2
R:R:L120	R:R:Y116	11.72	0	No	Yes	7	6	2	1
R:R:E288	R:R:Y116	5.61	1	Yes	Yes	5	6	1	1
R:R:D171	R:R:R188	8.34	1	No	No	4	5	2	2
R:R:I185	R:R:R183	6.26	0	No	Yes	3	3	2	1
R:R:D187	R:R:F189	4.78	0	No	No	3	3	1	2
R:R:E288	R:R:Y255	5.61	1	Yes	Yes	5	7	1	2
R:R:E288	R:R:F292	8.16	1	Yes	Yes	5	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	3ODU_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	561
Number of Links	627
Number of Hubs	82
Number of Links mediated by Hubs	317
Number of Communities	14
Number of Nodes involved in Communities	124
Number of Links involved in Communities	175

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	272361
Length Of Smallest Path	3
Average Path Length	23.5631
Length of Longest Path	58
Minimum Path Strength	1.38
Average Path Strength	7.091
Maximum Path Strength	22.58
Minimum Path Correlation	0.76
Average Path Correlation	0.985449
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	70.0279
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.6162
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • coreceptor activity • signaling receptor activity • cytoskeletal protein binding • myosin light chain binding • protein binding • binding • myosin binding • small molecule binding • C-C chemokine binding • chemokine binding • cytokine binding • G protein-coupled chemoattractant receptor activity • C-X-C motif chemokine 12 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • enzyme binding • virus receptor activity • exogenous protein binding • C-C chemokine receptor activity • ubiquitin binding • ubiquitin-like protein binding • actin binding • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion
Gene Ontology	Biological Process	• developmental process • multicellular organism development • multicellular organismal process • head development • central nervous system development • anatomical structure development • animal organ development • brain development • nervous system development • system development • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • biological regulation • cellular process • neuron recognition • cellular developmental process • cell development • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron development • cell recognition • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • response to stimulus • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • response to ultrasound • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • forebrain development • telencephalon cell migration • forebrain cell migration • cell migration • telencephalon development • cell motility • apoptotic process • cell death • programmed cell death • epithelium development • endothelium development • tube development • morphogenesis of an endothelium • endothelial tube morphogenesis • morphogenesis of an epithelium • tissue development • tissue morphogenesis • anatomical structure morphogenesis • tube morphogenesis • epithelial tube morphogenesis • regulation of viral process • viral process • membrane organization • cellular component organization • myelination • myelin maintenance • axon ensheathment • ensheathment of neurons • plasma membrane organization • cellular component organization or biogenesis • endomembrane system organization • cell chemotaxis • cellular response to stimulus • dendritic cell chemotaxis • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • immune system process • mononuclear cell migration • leukocyte chemotaxis • detection of external stimulus • system process • detection of stimulus involved in sensory perception of pain • nervous system process • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • response to decreased oxygen levels • response to hypoxia • response to stress • response to oxygen levels • cellular response to xenobiotic stimulus • response to xenobiotic stimulus • epithelial cell development • epithelial cell differentiation • regulation of growth • developmental growth • cell projection organization • neuron projection development • regulation of cell morphogenesis • positive regulation of developmental process • cell projection morphogenesis • neuron projection morphogenesis • positive regulation of developmental growth • developmental growth involved in morphogenesis • positive regulation of dendrite extension • regulation of cellular component organization • regulation of developmental process • plasma membrane bounded cell projection morphogenesis • cell growth • cell morphogenesis • dendrite extension • positive regulation of cellular process • regulation of anatomical structure morphogenesis • neuron projection extension • regulation of developmental growth • plasma membrane bounded cell projection organization • developmental cell growth • growth • regulation of dendrite extension • positive regulation of cell growth • regulation of cell growth • positive regulation of growth • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • detection of mechanical stimulus involved in sensory perception of pain • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • immune response • cell surface receptor signaling pathway • chemokine (C-X-C motif) ligand 12 signaling pathway • signaling • CXCL12-activated CXCR4 signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • C-X-C chemokine receptor CXCR4 signaling pathway • response to activity • regulation of cell motility • positive regulation of mesenchymal stem cell migration • positive regulation of cell migration • regulation of mesenchymal stem cell migration • mesenchymal stem cell migration • positive regulation of cell motility • regulation of cell migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • endothelial cell differentiation • angiogenesis • regulation of vasculature development • regulation of response to wounding • positive regulation of vascular wound healing • vascular wound healing • regulation of response to stress • regulation of multicellular organismal process • response to wounding • blood vessel development • positive regulation of response to wounding • wound healing • regulation of multicellular organismal development • blood vessel morphogenesis • angiogenesis involved in wound healing • positive regulation of angiogenesis • vasculature development • circulatory system development • positive regulation of vasculature development • positive regulation of wound healing • regulation of angiogenesis • regulation of wound healing • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • regulation of vascular wound healing • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of macrophage migration inhibitory factor signaling pathway • positive regulation of response to cytokine stimulus • macrophage migration inhibitory factor signaling pathway • regulation of signaling • regulation of macrophage migration inhibitory factor signaling pathway • regulation of cytokine-mediated signaling pathway • regulation of response to cytokine stimulus • regulation of cell communication • positive regulation of cytokine-mediated signaling pathway • positive regulation of signaling • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • regulation of programmed cell death • response to tacrolimus • response to oxygen-containing compound • response to nitrogen compound • heart process • circulatory system process • cardiac muscle contraction • heart contraction • muscle contraction • muscle system process • blood circulation • striated muscle contraction • biological process involved in interspecies interaction between organisms • response to other organism • response to external biotic stimulus • response to virus • response to biotic stimulus • defense response • inflammatory response • neuron migration • positive regulation of nervous system development • regulation of neurogenesis • regulation of cell differentiation • regulation of gliogenesis • positive regulation of gliogenesis • regulation of cell development • regulation of nervous system development • gliogenesis • positive regulation of cell differentiation • positive regulation of neurogenesis • positive regulation of oligodendrocyte differentiation • positive regulation of cell development • regulation of glial cell differentiation • positive regulation of glial cell differentiation • oligodendrocyte differentiation • glial cell differentiation • regulation of oligodendrocyte differentiation • defense response to bacterium • defense response to other organism • response to bacterium • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell leading edge • intracellular anatomical structure • cytoplasm • anchoring junction • cell junction • intracellular organelle • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lysosome • protein-containing complex • cytoplasmic vesicle • intracellular vesicle • early endosome • endosome • endomembrane system • late endosome • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITD
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	ITD
Name	(6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Synonyms
Identifier
Formula	C21 H34 N4 S2
Molecular Weight	406.651
SMILES
PubChem	25147749
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	64
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>3ODU_poly_Chain_R P C F R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V N L Y S S V W I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K G H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K F K T S A Q H A L T S G R P L E V L F Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8YU7 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	To be published
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	To be published
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/β1/γ2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol		3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/β1/γ2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol		3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/β1/γ2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol		3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol		2.72	2024-03-13	10.1101/2024.02.09.579708
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	-	3.31	2025-02-26	To be published
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	Cholesterol	-	3.2	2025-02-26	To be published
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	Cholesterol	-	3.01	2025-02-26	To be published
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE8 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	10.1126/science.1194396
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	10.1126/science.1194396
	3ODU (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		2.5	2010-10-27	10.1126/science.1194396

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Download 3ODU_poly.zip

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