psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	7.27	Yes	No	0	0	8
2	L:L:?1	R:R:S159	12.86	Yes	No	0	0	7
3	L:L:?1	R:R:T160	4.74	Yes	Yes	1	0	7
4	L:L:?1	R:R:S242	4.82	Yes	No	1	0	6
5	L:L:?1	R:R:F339	13.04	Yes	Yes	1	0	7
6	L:L:?1	R:R:F340	9.13	Yes	Yes	1	0	7
7	R:R:M132	R:R:T81	6.02	No	No	0	6	6
8	R:R:T81	R:R:W367	12.13	No	No	0	6	6
9	R:R:M128	R:R:T88	7.53	Yes	No	0	8	7
10	R:R:A374	R:R:T88	3.36	Yes	No	0	6	7
11	R:R:F125	R:R:I89	10.05	No	No	0	4	5
12	R:R:A117	R:R:N92	3.13	No	No	0	9	9
13	R:R:D120	R:R:N92	6.73	No	No	0	9	9
14	R:R:N92	R:R:P377	8.15	No	No	0	9	9
15	R:R:I93	R:R:M97	2.92	No	No	0	3	4
16	R:R:I93	R:R:M121	2.92	No	No	0	3	7
17	R:R:A117	R:R:V95	3.39	No	No	0	9	9
18	R:R:T381	R:R:V95	3.17	Yes	No	0	7	9
19	R:R:I96	R:R:M114	4.37	No	No	0	6	5
20	R:R:A117	R:R:I96	3.25	No	No	0	9	6
21	R:R:M114	R:R:V99	4.56	No	No	0	5	7
22	R:R:E102	R:R:L105	3.98	No	Yes	0	6	8
23	R:R:E102	R:R:R393	3.49	No	No	0	6	4
24	R:R:L105	R:R:T386	5.9	Yes	No	0	8	6
25	R:R:L105	R:R:Y387	9.38	Yes	Yes	0	8	8
26	R:R:Q106	R:R:Y111	6.76	No	No	0	7	4
27	R:R:N107	R:R:T109	4.39	No	No	3	7	8
28	R:R:N107	R:R:N110	6.81	No	No	3	7	9
29	R:R:N110	R:R:T109	4.39	No	No	3	9	8
30	R:R:N110	R:R:Y387	11.63	No	Yes	0	9	8
31	R:R:F112	R:R:H165	5.66	Yes	Yes	0	8	8
32	R:R:F112	R:R:I169	3.77	Yes	No	0	8	9
33	R:R:F112	R:R:K195	12.41	Yes	No	0	8	6
34	R:R:H165	R:R:S115	6.97	Yes	No	4	8	9
35	R:R:I196	R:R:S115	7.74	No	No	0	8	9
36	R:R:S115	R:R:W200	3.71	No	Yes	4	9	9
37	R:R:D120	R:R:L116	9.5	No	No	0	9	9
38	R:R:H165	R:R:L116	9	Yes	No	0	8	9
39	R:R:I118	R:R:L122	2.85	No	No	0	6	7
40	R:R:D120	R:R:S373	2.94	No	No	0	9	9
41	R:R:L122	R:R:M121	2.83	No	No	0	7	7
42	R:R:F125	R:R:M121	7.46	No	No	0	4	7
43	R:R:F158	R:R:L122	6.09	Yes	No	0	7	7
44	R:R:L123	R:R:V127	4.47	Yes	Yes	0	7	8
45	R:R:L123	R:R:M128	2.83	Yes	Yes	0	7	8
46	R:R:F158	R:R:L123	8.53	Yes	Yes	0	7	7
47	R:R:L123	R:R:S373	3	Yes	No	0	7	9
48	R:R:G124	R:R:M128	5.24	No	Yes	0	6	8
49	R:R:V127	R:R:W151	6.13	Yes	No	0	8	5
50	R:R:D155	R:R:V127	5.84	No	Yes	0	8	8
51	R:R:M128	R:R:Y370	8.38	Yes	Yes	0	8	7
52	R:R:L143	R:R:V130	2.98	Yes	No	0	5	4
53	R:R:V130	R:R:W151	7.36	No	No	0	4	5
54	R:R:S131	R:R:W151	3.71	No	No	0	7	5
55	R:R:L133	R:R:Y137	3.52	No	No	2	4	4
56	R:R:L133	R:R:P142	3.28	No	Yes	2	4	3
57	R:R:I135	R:R:W367	4.7	No	No	0	5	6
58	R:R:P142	R:R:Y137	11.13	Yes	No	2	3	4
59	R:R:N363	R:R:Y139	3.49	No	No	0	4	3
60	R:R:P142	R:R:W141	4.05	Yes	Yes	2	3	7
61	R:R:L143	R:R:W141	17.08	Yes	Yes	2	5	7
62	R:R:L147	R:R:W141	4.56	No	Yes	0	5	7
63	R:R:C148	R:R:W141	10.45	Yes	Yes	2	9	7
64	R:R:C227	R:R:W141	16.98	No	Yes	2	9	7
65	R:R:L143	R:R:P142	3.28	Yes	Yes	2	5	3
66	R:R:L143	R:R:P144	3.28	Yes	No	0	5	7
67	R:R:L147	R:R:V150	2.98	No	No	0	5	4
68	R:R:C148	R:R:V221	3.42	Yes	No	0	9	3
69	R:R:C148	R:R:F222	4.19	Yes	No	0	9	2
70	R:R:C148	R:R:C227	7.28	Yes	No	2	9	9
71	R:R:A149	R:R:L215	3.15	No	No	0	6	5
72	R:R:L154	R:R:V150	2.98	No	No	0	5	4
73	R:R:I152	R:R:I210	2.94	No	No	0	5	6
74	R:R:L154	R:R:Y153	3.52	No	Yes	0	5	6
75	R:R:L157	R:R:Y153	3.52	No	Yes	6	6	6
76	R:R:S207	R:R:Y153	5.09	No	Yes	6	7	6
77	R:R:P211	R:R:Y153	6.95	No	Yes	0	5	6
78	R:R:F158	R:R:L154	3.65	Yes	No	0	7	5
79	R:R:D155	R:R:Y370	4.6	No	Yes	0	8	7
80	R:R:S207	R:R:V156	3.23	No	No	0	7	6
81	R:R:L157	R:R:V204	2.98	No	No	0	6	4
82	R:R:L157	R:R:S207	7.51	No	No	6	6	7
83	R:R:F158	R:R:W200	3.01	Yes	Yes	0	7	9
84	R:R:M164	R:R:T160	3.01	No	Yes	0	6	7
85	R:R:S242	R:R:T160	6.4	No	Yes	1	6	7
86	R:R:A161	R:R:W200	5.19	No	Yes	0	8	9
87	R:R:A161	R:R:S203	3.42	No	No	0	8	8
88	R:R:I163	R:R:P246	3.39	No	No	0	8	9
89	R:R:I163	R:R:W336	3.52	No	Yes	0	8	8
90	R:R:M164	R:R:V199	3.04	No	No	0	6	6
91	R:R:M164	R:R:P246	3.35	No	No	0	6	9
92	R:R:H165	R:R:V199	6.92	Yes	No	0	8	6
93	R:R:H165	R:R:W200	4.23	Yes	Yes	4	8	9
94	R:R:F332	R:R:L166	4.87	Yes	No	0	9	8
95	R:R:L166	R:R:N376	6.87	No	No	0	8	9
96	R:R:L166	R:R:Y380	3.52	No	Yes	0	8	9
97	R:R:C167	R:R:I249	3.27	No	No	0	6	6
98	R:R:I169	R:R:R173	5.01	No	No	5	9	9
99	R:R:I169	R:R:Y380	7.25	No	Yes	5	9	9
100	R:R:S170	R:R:T253	3.2	No	No	0	9	5
101	R:R:I249	R:R:L171	4.28	No	No	0	6	6
102	R:R:L171	R:R:T253	4.42	No	No	0	6	5
103	R:R:D172	R:R:H183	6.3	No	No	0	9	7
104	R:R:D172	R:R:K195	5.53	No	No	0	9	6
105	R:R:R173	R:R:Y380	4.12	No	Yes	5	9	9
106	R:R:Q178	R:R:Y174	9.02	No	Yes	0	6	8
107	R:R:L256	R:R:Y174	5.86	No	Yes	0	5	8
108	R:R:T257	R:R:Y174	6.24	No	Yes	0	9	8
109	R:R:A176	R:R:H183	7.32	No	No	0	8	7
110	R:R:N179	R:R:Q178	5.28	No	No	0	6	6
111	R:R:Q178	R:R:S260	7.22	No	No	0	6	6
112	R:R:H183	R:R:N187	6.38	No	No	0	7	6
113	R:R:F186	R:R:R185	8.55	No	No	0	4	4
114	R:R:K191	R:R:N187	4.2	No	No	0	6	6
115	R:R:S188	R:R:T190	3.2	No	No	0	7	5
116	R:R:F193	R:R:R189	9.62	No	No	0	4	4
117	R:R:K191	R:R:K195	4.31	No	No	0	6	6
118	R:R:I202	R:R:I206	2.94	No	No	0	5	6
119	R:R:I210	R:R:P211	5.08	No	No	0	6	5
120	R:R:F234	R:R:I210	5.02	No	No	0	7	6
121	R:R:F213	R:R:V212	5.24	No	No	0	4	5
122	R:R:E224	R:R:K223	10.8	No	No	0	2	3
123	R:R:L228	R:R:S226	4.5	No	No	0	4	4
124	R:R:F234	R:R:L229	3.65	No	No	0	7	4
125	R:R:D231	R:R:F234	3.58	No	No	0	5	7
126	R:R:D232	R:R:V347	7.3	No	No	0	4	5
127	R:R:N343	R:R:V235	4.43	No	No	0	7	6
128	R:R:V235	R:R:V347	3.21	No	No	0	6	5
129	R:R:F240	R:R:L236	3.65	No	No	7	4	6
130	R:R:I344	R:R:L236	2.85	No	No	7	5	6
131	R:R:N343	R:R:S239	4.47	No	No	0	7	6
132	R:R:F240	R:R:F244	5.36	No	No	0	4	5
133	R:R:F240	R:R:I344	3.77	No	No	7	4	5
134	R:R:F243	R:R:F244	8.57	Yes	No	0	8	5
135	R:R:F243	R:R:F332	5.36	Yes	Yes	1	8	9
136	R:R:F243	R:R:W336	3.01	Yes	Yes	1	8	8
137	R:R:C337	R:R:F243	4.19	No	Yes	0	6	8
138	R:R:F243	R:R:F340	20.36	Yes	Yes	1	8	7
139	R:R:I245	R:R:P246	5.08	No	No	0	5	9
140	R:R:I252	R:R:T248	3.04	No	No	0	5	3
141	R:R:F332	R:R:M250	12.44	Yes	No	0	9	8
142	R:R:F329	R:R:V251	3.93	Yes	No	0	8	5
143	R:R:I252	R:R:L256	2.85	No	No	0	5	5
144	R:R:F255	R:R:Y254	4.13	No	Yes	0	1	9
145	R:R:I258	R:R:Y254	8.46	No	Yes	0	5	9
146	R:R:G326	R:R:Y254	2.9	No	Yes	0	6	9
147	R:R:F329	R:R:Y254	5.16	Yes	Yes	0	8	9
148	R:R:L325	R:R:T257	2.95	No	No	0	8	9
149	R:R:C322	R:R:I258	3.27	No	No	0	7	5
150	R:R:I315	R:R:N317	2.83	No	No	0	5	6
151	R:R:E318	R:R:I315	4.1	No	No	0	8	5
152	R:R:Q319	R:R:S316	5.78	No	No	0	5	6
153	R:R:E318	R:R:Q319	5.1	No	No	0	8	5
154	R:R:F383	R:R:V324	3.93	No	No	0	7	8
155	R:R:F329	R:R:V333	6.55	Yes	No	0	8	6
156	R:R:F330	R:R:V334	3.93	No	No	0	5	5
157	R:R:L331	R:R:V379	4.47	No	Yes	0	6	8
158	R:R:F332	R:R:W336	5.01	Yes	Yes	1	9	8
159	R:R:I368	R:R:M335	2.92	No	No	0	7	8
160	R:R:M335	R:R:S372	4.6	No	No	0	8	9
161	R:R:F340	R:R:W336	3.01	Yes	Yes	1	7	8
162	R:R:G369	R:R:W336	5.63	No	Yes	0	7	8
163	R:R:S372	R:R:W336	4.94	No	Yes	0	9	8
164	R:R:C337	R:R:I341	3.27	No	No	0	6	6
165	R:R:F365	R:R:P338	4.33	Yes	No	0	5	9
166	R:R:F339	R:R:F340	10.72	Yes	Yes	1	7	7
167	R:R:F339	R:R:L362	4.87	Yes	No	0	7	3
168	R:R:I341	R:R:M345	2.92	No	No	0	6	4
169	R:R:F365	R:R:T342	3.89	Yes	No	0	5	5
170	R:R:E355	R:R:K350	5.4	No	No	0	3	1
171	R:R:D356	R:R:N354	13.46	No	No	0	2	1
172	R:R:N354	R:R:V357	7.39	No	No	0	1	5
173	R:R:E355	R:R:I358	8.2	No	Yes	0	3	4
174	R:R:I358	R:R:V357	3.07	Yes	No	0	4	5
175	R:R:V366	R:R:Y370	5.05	No	Yes	0	6	7
176	R:R:W367	R:R:Y370	13.5	No	Yes	0	6	7
177	R:R:N376	R:R:S372	4.47	No	No	0	9	9
178	R:R:T381	R:R:Y387	13.73	Yes	Yes	0	7	8
179	R:R:F391	R:R:T381	3.89	No	Yes	0	6	7
180	R:R:N384	R:R:T386	8.77	No	No	0	9	6
181	R:R:N384	R:R:Y387	5.81	No	Yes	0	9	8
182	R:R:K385	R:R:R388	13.61	No	No	0	5	9
183	R:R:K223	R:R:L228	2.82	No	No	0	3	4
184	R:R:A168	R:R:F112	2.77	No	Yes	0	7	8
185	R:R:D217	R:R:K220	2.77	No	No	0	4	3
186	R:R:D231	R:R:K220	2.77	No	No	0	5	3
187	R:R:F340	R:R:S239	2.64	Yes	No	0	7	6
188	R:R:F365	R:R:V364	2.62	Yes	No	0	5	4
189	R:R:D217	R:R:Q216	2.61	No	No	0	4	6
190	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
191	R:R:V99	R:R:Y111	2.52	No	No	0	7	4
192	R:R:V379	R:R:Y380	2.52	Yes	Yes	0	8	9
193	R:R:T253	R:R:Y174	2.5	No	Yes	0	5	8
194	R:R:F329	R:R:M250	2.49	Yes	No	0	8	8
195	R:R:F243	R:R:L247	2.44	Yes	No	1	8	6
196	R:R:F332	R:R:L247	2.44	Yes	No	1	9	6
197	R:R:F365	R:R:L361	2.44	Yes	No	0	5	4
198	R:R:F391	R:R:L382	2.44	No	No	0	6	5
199	R:R:T134	R:R:W141	2.43	No	Yes	0	5	7
200	R:R:D218	R:R:F222	2.39	No	No	0	3	2
201	R:R:L325	R:R:Y254	2.34	No	Yes	0	8	9
202	R:R:F339	R:R:F365	2.14	Yes	Yes	0	7	5
203	R:R:A90	R:R:G91	1.95	No	No	0	4	8
204	R:R:A149	R:R:G214	1.95	No	No	0	6	7
205	R:R:G225	R:R:S226	1.86	No	No	0	3	4
206	R:R:G205	R:R:V204	1.84	No	No	0	4	4
207	R:R:G238	R:R:V241	1.84	No	No	0	6	4
208	L:L:?1	R:R:G238	1.83	Yes	No	0	0	6
209	R:R:C349	R:R:C353	1.82	No	No	0	3	3
210	R:R:A390	R:R:A98	1.79	No	No	0	7	7
211	R:R:A108	R:R:A192	1.79	No	No	0	5	7
212	R:R:A374	R:R:V84	1.7	Yes	No	0	6	7
213	R:R:M128	R:R:P129	1.68	Yes	No	0	8	8
214	R:R:M208	R:R:P209	1.68	No	No	0	4	7
215	R:R:C349	R:R:I348	1.64	No	No	0	3	4
216	R:R:C353	R:R:I358	1.64	No	Yes	0	3	4
217	R:R:E355	R:R:G359	1.64	No	No	0	3	2
218	R:R:N179	R:R:P180	1.63	No	No	0	6	8
219	R:R:A346	R:R:I358	1.62	No	Yes	0	4	4
220	R:R:A230	R:R:K223	1.61	No	No	0	3	3
221	R:R:V83	R:R:V84	1.6	No	No	0	4	7
222	R:R:V324	R:R:V328	1.6	No	No	0	8	8
223	R:R:V328	R:R:V379	1.6	No	Yes	0	8	8
224	R:R:V375	R:R:V379	1.6	No	Yes	0	6	8
225	R:R:A374	R:R:L87	1.58	Yes	No	0	6	4
226	R:R:A98	R:R:L105	1.58	No	Yes	0	7	8
227	R:R:A321	R:R:L261	1.58	No	No	0	8	8
228	R:R:A374	R:R:L371	1.58	Yes	No	0	6	4
229	R:R:A108	R:R:N187	1.56	No	No	0	5	6
230	R:R:I96	R:R:S100	1.55	No	No	0	6	1
231	R:R:I163	R:R:S162	1.55	No	No	0	8	9
232	R:R:I348	R:R:V347	1.54	No	No	0	4	5
233	R:R:I206	R:R:T160	1.52	No	Yes	0	6	7
234	R:R:I177	R:R:T257	1.52	No	No	0	9	9
235	R:R:I197	R:R:T201	1.52	No	No	0	2	4
236	R:R:M208	R:R:V204	1.52	No	No	0	4	4
237	R:R:M335	R:R:V334	1.52	No	No	0	8	5
238	R:R:K104	R:R:T386	1.5	No	No	0	6	6
239	R:R:L126	R:R:V127	1.49	No	Yes	0	5	8
240	R:R:I85	R:R:I89	1.47	No	No	0	6	5
241	R:R:L113	R:R:T381	1.47	No	Yes	0	8	7
242	R:R:L194	R:R:T190	1.47	No	No	0	3	5
243	R:R:E351	R:R:S352	1.44	No	No	0	5	2
244	R:R:I177	R:R:L261	1.43	No	No	0	9	8
245	R:R:I327	R:R:L331	1.43	No	No	0	6	6
246	R:R:L94	R:R:M97	1.41	No	No	0	6	4
247	R:R:L101	R:R:M97	1.41	No	No	0	5	4
248	R:R:K385	R:R:N384	1.4	No	No	0	5	9
249	R:R:D231	R:R:N233	1.35	No	No	0	5	3
250	R:R:E318	R:R:L261	1.33	No	No	0	8	8
251	R:R:F222	R:R:S145	1.32	No	No	0	2	3
252	R:R:H182	R:R:N179	1.28	No	No	0	5	6
253	R:R:V175	R:R:Y174	1.26	No	Yes	0	5	8
254	R:R:T134	R:R:Y139	1.25	No	No	0	5	3
255	R:R:I181	R:R:R185	1.25	No	No	0	7	4
256	R:R:F186	R:R:K191	1.24	No	No	0	4	6
257	R:R:F213	R:R:Q216	1.17	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.67	7	1	0
2	R:R:L105	5.21	4	0	8
3	R:R:F112	6.1525	4	0	8
4	R:R:L123	4.7075	4	0	7
5	R:R:V127	4.4825	4	0	8
6	R:R:M128	5.132	5	0	8
7	R:R:W141	9.25833	6	2	7
8	R:R:P142	5.435	4	2	3
9	R:R:L143	6.655	4	2	5
10	R:R:C148	6.335	4	2	9
11	R:R:Y153	4.77	4	6	6
12	R:R:F158	5.32	4	0	7
13	R:R:T160	3.9175	4	1	7
14	R:R:H165	6.556	5	4	8
15	R:R:Y174	4.976	5	0	8
16	R:R:W200	3.746	5	4	9
17	R:R:F243	7.32167	6	1	8
18	R:R:Y254	4.598	5	0	9
19	R:R:F329	4.5325	4	0	8
20	R:R:F332	6.024	5	1	9
21	R:R:W336	4.18667	6	1	8
22	R:R:F339	7.6925	4	1	7
23	R:R:F340	9.172	5	1	7
24	R:R:I358	3.6325	4	0	4
25	R:R:F365	3.084	5	0	5
26	R:R:Y370	7.8825	4	0	7
27	R:R:A374	2.055	4	0	6
28	R:R:V379	2.5475	4	0	8
29	R:R:Y380	4.3525	4	5	9
30	R:R:T381	5.565	4	0	7
31	R:R:Y387	10.1375	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	95.2265	7.27	Yes	No	0	0	8
2	R:R:D155	R:R:Y370	18.7433	4.6	No	Yes	0	8	7
3	R:R:M128	R:R:Y370	15.48	8.38	Yes	Yes	0	8	7
4	R:R:M128	R:R:T88	14.2844	7.53	Yes	No	0	8	7
5	R:R:A374	R:R:T88	11.9471	3.36	Yes	No	0	6	7
6	R:R:D155	R:R:V127	78.2632	5.84	No	Yes	0	8	8
7	R:R:L123	R:R:V127	63.6012	4.47	Yes	Yes	0	7	8
8	R:R:F158	R:R:L123	63.3855	8.53	Yes	Yes	0	7	7
9	R:R:F158	R:R:L122	26.0608	6.09	Yes	No	0	7	7
10	R:R:L122	R:R:M121	20.9907	2.83	No	No	0	7	7
11	R:R:L123	R:R:S373	36.5696	3	Yes	No	0	7	9
12	R:R:D120	R:R:S373	35.2931	2.94	No	No	0	9	9
13	R:R:D120	R:R:N92	57.9737	6.73	No	No	0	9	9
14	R:R:A117	R:R:N92	54.5397	3.13	No	No	0	9	9
15	R:R:I93	R:R:M121	10.6347	2.92	No	No	0	3	7
16	R:R:A117	R:R:V95	42.1072	3.39	No	No	0	9	9
17	R:R:T381	R:R:V95	40.2014	3.17	Yes	No	0	7	9
18	R:R:A117	R:R:I96	12.8731	3.25	No	No	0	9	6
19	R:R:T381	R:R:Y387	32.9198	13.73	Yes	Yes	0	7	8
20	R:R:L105	R:R:Y387	14.7789	9.38	Yes	Yes	0	8	8
21	R:R:N384	R:R:Y387	10.5448	5.81	No	Yes	0	9	8
22	L:L:?1	R:R:T160	13.4304	4.74	Yes	Yes	1	0	7
23	R:R:M164	R:R:T160	11.165	3.01	No	Yes	0	6	7
24	R:R:M164	R:R:V199	17.3409	3.04	No	No	0	6	6
25	R:R:H165	R:R:V199	17.5027	6.92	Yes	No	0	8	6
26	R:R:F112	R:R:H165	53.8116	5.66	Yes	Yes	0	8	8
27	R:R:F112	R:R:I169	47.5998	3.77	Yes	No	0	8	9
28	L:L:?1	R:R:F340	94.0309	9.13	Yes	Yes	1	0	7
29	R:R:F243	R:R:F340	51.0428	20.36	Yes	Yes	1	8	7
30	R:R:F243	R:R:F332	43.7972	5.36	Yes	Yes	1	8	9
31	R:R:F332	R:R:L166	46.8087	4.87	Yes	No	0	9	8
32	R:R:L166	R:R:Y380	49.3168	3.52	No	Yes	0	8	9
33	R:R:I169	R:R:Y380	46.4042	7.25	No	Yes	5	9	9
34	R:R:F340	R:R:W336	49.8382	3.01	Yes	Yes	1	7	8
35	R:R:F332	R:R:W336	44.0399	5.01	Yes	Yes	1	9	8
36	R:R:F112	R:R:K195	23.8403	12.41	Yes	No	0	8	6
37	R:R:F158	R:R:W200	35.0683	3.01	Yes	Yes	0	7	9
38	R:R:H165	R:R:W200	35.8234	4.23	Yes	Yes	4	8	9
39	R:R:H165	R:R:L116	26.6451	9	Yes	No	0	8	9
40	R:R:V127	R:R:W151	32.4164	6.13	Yes	No	0	8	5
41	R:R:V130	R:R:W151	28.3531	7.36	No	No	0	4	5
42	R:R:L143	R:R:V130	26.3484	2.98	Yes	No	0	5	4
43	R:R:L143	R:R:W141	18.5095	17.08	Yes	Yes	2	5	7
44	R:R:F158	R:R:L154	62.6753	3.65	Yes	No	0	7	5
45	R:R:L154	R:R:V150	17.4667	2.98	No	No	0	5	4
46	R:R:L147	R:R:V150	15.1205	2.98	No	No	0	5	4
47	R:R:L147	R:R:W141	13.8529	4.56	No	Yes	0	5	7
48	R:R:C148	R:R:W141	13.1877	10.45	Yes	Yes	2	9	7
49	R:R:L154	R:R:Y153	49.5325	3.52	No	Yes	0	5	6
50	R:R:P211	R:R:Y153	30.3308	6.95	No	Yes	0	5	6
51	R:R:I210	R:R:P211	27.8497	5.08	No	No	0	6	5
52	R:R:L157	R:R:Y153	13.1158	3.52	No	Yes	6	6	6
53	R:R:L157	R:R:V204	10.5987	2.98	No	No	0	6	4
54	R:R:S372	R:R:W336	11.0122	4.94	No	Yes	0	9	8
55	R:R:F332	R:R:M250	100	12.44	Yes	No	0	9	8
56	R:R:F329	R:R:M250	97.3211	2.49	Yes	No	0	8	8
57	R:R:F329	R:R:Y254	89.1226	5.16	Yes	Yes	0	8	9
58	R:R:L325	R:R:Y254	75.5034	2.34	No	Yes	0	8	9
59	R:R:L325	R:R:T257	72.9684	2.95	No	No	0	8	9
60	R:R:T257	R:R:Y174	47.1863	6.24	No	Yes	0	9	8
61	R:R:T253	R:R:Y174	16.1722	2.5	No	Yes	0	5	8
62	R:R:Q178	R:R:Y174	16.1722	9.02	No	Yes	0	6	8
63	R:R:K191	R:R:K195	15.3722	4.31	No	No	0	6	6
64	R:R:F234	R:R:I210	22.8065	5.02	No	No	0	7	6
65	R:R:D231	R:R:F234	18.3657	3.58	No	No	0	5	7
66	R:R:D231	R:R:K220	13.2057	2.77	No	No	0	5	3
67	R:R:D217	R:R:K220	10.5987	2.77	No	No	0	4	3
68	R:R:F340	R:R:S239	41.1273	2.64	Yes	No	0	7	6
69	R:R:N343	R:R:S239	38.6911	4.47	No	No	0	7	6
70	R:R:N343	R:R:V235	36.228	4.43	No	No	0	7	6
71	R:R:V235	R:R:V347	33.7469	3.21	No	No	0	6	5
72	R:R:I177	R:R:T257	25.0809	1.52	No	No	0	9	9
73	R:R:I177	R:R:L261	22.2132	1.43	No	No	0	9	8
74	R:R:E318	R:R:L261	15.8666	1.33	No	No	0	8	8
75	R:R:V379	R:R:Y380	16.8375	2.52	Yes	Yes	0	8	9
76	R:R:M335	R:R:S372	10.5268	4.6	No	No	0	8	9
77	R:R:F339	R:R:F365	11.9471	2.14	Yes	Yes	0	7	5
78	R:R:I348	R:R:V347	28.7666	1.54	No	No	0	4	5
79	R:R:C349	R:R:I348	26.2406	1.64	No	No	0	3	4
80	R:R:C349	R:R:C353	23.6965	1.82	No	No	0	3	3
81	R:R:C353	R:R:I358	21.1345	1.64	No	Yes	0	3	4
82	R:R:D120	R:R:L116	25.4764	9.5	No	No	0	9	9
83	R:R:L123	R:R:M128	15.1564	2.83	Yes	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	7.27	1	Yes	No	0	8	0	1
L:L:?1	R:R:S159	12.86	1	Yes	No	0	7	0	1
L:L:?1	R:R:T160	4.74	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S242	4.82	1	Yes	No	0	6	0	1
L:L:?1	R:R:F339	13.04	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	9.13	1	Yes	Yes	0	7	0	1
R:R:D155	R:R:V127	5.84	0	No	Yes	8	8	1	2
R:R:D155	R:R:Y370	4.6	0	No	Yes	8	7	1	2
R:R:M164	R:R:T160	3.01	0	No	Yes	6	7	2	1
R:R:S242	R:R:T160	6.4	1	No	Yes	6	7	1	1
R:R:F243	R:R:W336	3.01	1	Yes	Yes	8	8	2	2
R:R:F243	R:R:F340	20.36	1	Yes	Yes	8	7	2	1
R:R:F340	R:R:W336	3.01	1	Yes	Yes	7	8	1	2
R:R:F339	R:R:F340	10.72	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:L362	4.87	1	Yes	No	7	3	1	2
R:R:F340	R:R:S239	2.64	1	Yes	No	7	6	1	2
R:R:F339	R:R:F365	2.14	1	Yes	Yes	7	5	1	2
R:R:G238	R:R:V241	1.84	0	No	No	6	4	1	2
L:L:?1	R:R:G238	1.83	1	Yes	No	0	6	0	1
R:R:I206	R:R:T160	1.52	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LL7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	243
Number of Links	257
Number of Hubs	31
Number of Links mediated by Hubs	116
Number of Communities	7
Number of Nodes involved in Communities	31
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	31949
Length Of Smallest Path	3
Average Path Length	12.9474
Length of Longest Path	29
Minimum Path Strength	1.38
Average Path Strength	5.35164
Maximum Path Strength	17.03
Minimum Path Correlation	0.7
Average Path Correlation	0.919655
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	46.9401
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.0471
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9LL7_nogp_Chain_R L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.54	2025-04-02	10.1038/s41467-025-57956-7
	9AS8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.54	2025-04-02	10.1038/s41467-025-57956-7
	9LL9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.76	2026-01-14	To be published
	9LL9 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.76	2026-01-14	To be published
	9LLA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.27	2026-01-14	To be published
	9LLA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-		3.27	2026-01-14	To be published
	9LLB	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.98	2026-01-14	To be published
	9LLB (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-		2.98	2026-01-14	To be published
	9LL7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	Gi1/β1/γ2	2.84	2026-01-14	To be published
	9LL7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.84	2026-01-14	To be published
	9LL8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	Gi1/β1/γ2	2.62	2026-01-14	To be published
	9LL8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.62	2026-01-14	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LL7_nogp.zip

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