psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	6.89	Yes	No	1	0	8
2	L:L:?1	R:R:V156	6.05	Yes	No	0	0	6
3	L:L:?1	R:R:S159	15.25	Yes	No	0	0	7
4	L:L:?1	R:R:T160	5.99	Yes	Yes	1	0	7
5	L:L:?1	R:R:F234	6.19	Yes	No	0	0	7
6	L:L:?1	R:R:S242	4.58	Yes	No	1	0	6
7	L:L:?1	R:R:F339	14.85	Yes	Yes	1	0	7
8	L:L:?1	R:R:F340	11.14	Yes	Yes	1	0	7
9	L:L:?1	R:R:N343	4.19	Yes	Yes	1	0	7
10	R:R:M132	R:R:T81	6.02	No	No	0	6	6
11	R:R:T81	R:R:W367	12.13	No	No	0	6	6
12	R:R:I85	R:R:M128	4.37	No	Yes	0	6	8
13	R:R:M128	R:R:T88	4.52	Yes	No	0	8	7
14	R:R:A374	R:R:T88	5.03	No	No	0	6	7
15	R:R:D120	R:R:N92	13.46	No	No	0	9	9
16	R:R:M121	R:R:N92	8.41	Yes	No	0	7	9
17	R:R:I93	R:R:M121	4.37	No	Yes	0	3	7
18	R:R:F391	R:R:L94	8.53	Yes	No	0	6	6
19	R:R:F391	R:R:V95	3.93	Yes	No	0	6	9
20	R:R:I96	R:R:M114	5.83	No	No	0	6	5
21	R:R:I96	R:R:M121	2.92	No	Yes	0	6	7
22	R:R:A98	R:R:F391	2.77	No	Yes	0	7	6
23	R:R:M114	R:R:V99	3.04	No	No	0	5	7
24	R:R:V99	R:R:Y387	3.79	No	Yes	0	7	8
25	R:R:L101	R:R:R393	4.86	No	No	0	5	4
26	R:R:E102	R:R:K104	2.7	No	No	3	6	6
27	R:R:E102	R:R:T386	4.23	No	Yes	3	6	6
28	R:R:E102	R:R:R393	4.65	No	No	0	6	4
29	R:R:K103	R:R:Q106	5.42	No	No	0	6	7
30	R:R:K104	R:R:L105	5.64	No	Yes	3	6	8
31	R:R:K104	R:R:T386	6.01	No	Yes	3	6	6
32	R:R:L105	R:R:N110	4.12	Yes	Yes	3	8	9
33	R:R:L105	R:R:T386	10.32	Yes	Yes	3	8	6
34	R:R:L105	R:R:Y387	8.21	Yes	Yes	3	8	8
35	R:R:N107	R:R:N110	6.81	No	Yes	0	7	9
36	R:R:N110	R:R:T109	4.39	Yes	No	0	9	8
37	R:R:N110	R:R:Y387	8.14	Yes	Yes	3	9	8
38	R:R:F112	R:R:H165	10.18	Yes	Yes	2	8	8
39	R:R:A168	R:R:F112	2.77	No	Yes	0	7	8
40	R:R:F112	R:R:I169	5.02	Yes	No	2	8	9
41	R:R:F112	R:R:K195	12.41	Yes	No	0	8	6
42	R:R:F112	R:R:I196	2.51	Yes	No	0	8	8
43	R:R:F112	R:R:V199	2.62	Yes	No	2	8	6
44	R:R:H165	R:R:S115	8.37	Yes	No	2	8	9
45	R:R:I196	R:R:S115	7.74	No	No	0	8	9
46	R:R:S115	R:R:W200	4.94	No	Yes	2	9	9
47	R:R:H165	R:R:L116	6.43	Yes	No	0	8	9
48	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
49	R:R:D120	R:R:P377	3.22	No	No	0	9	9
50	R:R:F125	R:R:M121	4.98	No	Yes	0	4	7
51	R:R:L122	R:R:L126	2.77	No	No	0	7	5
52	R:R:F158	R:R:L122	3.65	No	No	0	7	7
53	R:R:G124	R:R:L123	3.42	No	Yes	0	6	7
54	R:R:L123	R:R:V127	4.47	Yes	Yes	0	7	8
55	R:R:F158	R:R:L123	8.53	No	Yes	0	7	7
56	R:R:L123	R:R:S373	3	Yes	No	0	7	9
57	R:R:G124	R:R:M128	5.24	No	Yes	0	6	8
58	R:R:V127	R:R:W151	7.36	Yes	Yes	1	8	5
59	R:R:D155	R:R:V127	7.3	No	Yes	1	8	8
60	R:R:V127	R:R:Y370	3.79	Yes	No	1	8	7
61	R:R:V130	R:R:W141	3.68	No	Yes	1	4	7
62	R:R:V130	R:R:W151	20.84	No	Yes	1	4	5
63	R:R:S131	R:R:W151	6.18	No	Yes	0	7	5
64	R:R:I135	R:R:Y139	7.25	No	No	0	5	3
65	R:R:L136	R:R:Y137	3.52	No	No	0	5	4
66	R:R:P142	R:R:Y137	5.56	No	No	0	3	4
67	R:R:S226	R:R:Y139	5.09	No	No	0	4	3
68	R:R:N363	R:R:Y139	9.3	No	No	0	4	3
69	R:R:P142	R:R:W141	4.05	No	Yes	0	3	7
70	R:R:L143	R:R:W141	5.69	No	Yes	0	5	7
71	R:R:C148	R:R:W141	9.14	Yes	Yes	1	9	7
72	R:R:W141	R:R:W151	7.5	Yes	Yes	1	7	5
73	R:R:C227	R:R:W141	3.92	No	Yes	1	9	7
74	R:R:L143	R:R:P144	4.93	No	No	0	5	7
75	R:R:L143	R:R:L147	4.15	No	No	0	5	5
76	R:R:C148	R:R:V221	3.42	Yes	No	1	9	3
77	R:R:C148	R:R:F222	4.19	Yes	No	1	9	2
78	R:R:C148	R:R:C227	7.28	Yes	No	1	9	9
79	R:R:C227	R:R:I152	3.27	No	No	0	9	5
80	R:R:I152	R:R:L229	8.56	No	No	0	5	4
81	R:R:L157	R:R:Y153	3.52	No	No	4	6	6
82	R:R:S207	R:R:Y153	7.63	No	No	4	7	6
83	R:R:P211	R:R:Y153	6.95	No	No	0	5	6
84	R:R:F158	R:R:L154	6.09	No	No	0	7	5
85	R:R:D155	R:R:Y370	10.34	No	No	1	8	7
86	R:R:S207	R:R:V156	3.23	No	No	0	7	6
87	R:R:L157	R:R:V204	2.98	No	No	0	6	4
88	R:R:L157	R:R:S207	4.5	No	No	4	6	7
89	R:R:M164	R:R:T160	3.01	No	Yes	0	6	7
90	R:R:I206	R:R:T160	6.08	No	Yes	0	6	7
91	R:R:S242	R:R:T160	6.4	No	Yes	1	6	7
92	R:R:A161	R:R:W200	3.89	No	Yes	0	8	9
93	R:R:A161	R:R:S203	3.42	No	No	0	8	8
94	R:R:I163	R:R:P246	3.39	No	No	0	8	9
95	R:R:M164	R:R:S203	3.07	No	No	0	6	8
96	R:R:M164	R:R:P246	3.35	No	No	0	6	9
97	R:R:H165	R:R:V199	5.54	Yes	No	2	8	6
98	R:R:H165	R:R:W200	5.29	Yes	Yes	2	8	9
99	R:R:L166	R:R:N376	5.49	No	No	0	8	9
100	R:R:L166	R:R:Y380	7.03	No	Yes	0	8	9
101	R:R:C167	R:R:I249	3.27	No	No	0	6	6
102	R:R:I169	R:R:R173	5.01	No	No	2	9	9
103	R:R:I169	R:R:Y380	6.04	No	Yes	2	9	9
104	R:R:S170	R:R:T253	6.4	No	No	0	9	5
105	R:R:I249	R:R:L171	2.85	No	No	0	6	6
106	R:R:L171	R:R:T253	2.95	No	No	0	6	5
107	R:R:D172	R:R:K195	12.44	No	No	0	9	6
108	R:R:R173	R:R:Y380	4.12	No	Yes	2	9	9
109	R:R:Q178	R:R:Y174	9.02	No	Yes	0	6	8
110	R:R:T253	R:R:Y174	2.5	No	Yes	0	5	8
111	R:R:L256	R:R:Y174	4.69	No	Yes	0	5	8
112	R:R:T257	R:R:Y174	6.24	No	Yes	0	9	8
113	R:R:A176	R:R:H183	7.32	No	No	0	8	7
114	R:R:N179	R:R:Q178	5.28	Yes	No	0	6	6
115	R:R:Q178	R:R:S260	8.66	No	No	0	6	6
116	R:R:H182	R:R:N179	2.55	No	Yes	0	5	6
117	R:R:H182	R:R:I181	2.65	No	No	0	5	7
118	R:R:H183	R:R:K191	3.93	No	No	0	7	6
119	R:R:F186	R:R:R185	5.34	No	No	0	4	4
120	R:R:K191	R:R:N187	5.6	No	No	0	6	6
121	R:R:R189	R:R:S188	5.27	No	No	0	4	7
122	R:R:S188	R:R:T190	3.2	No	No	0	7	5
123	R:R:L194	R:R:T190	2.95	No	No	0	3	5
124	R:R:K191	R:R:K195	2.87	No	No	0	6	6
125	R:R:F193	R:R:I197	6.28	No	No	0	4	2
126	R:R:G205	R:R:M208	3.49	No	No	0	4	4
127	R:R:M208	R:R:P209	3.35	No	No	0	4	7
128	R:R:I210	R:R:P211	5.08	No	No	0	6	5
129	R:R:D217	R:R:G214	5.03	No	No	0	4	7
130	R:R:L215	R:R:Q216	3.99	No	No	0	5	6
131	R:R:K220	R:R:S219	9.18	No	No	0	3	3
132	R:R:F222	R:R:V221	2.62	No	No	1	2	3
133	R:R:E224	R:R:K223	5.4	No	No	0	2	3
134	R:R:L228	R:R:S226	4.5	No	No	0	4	4
135	R:R:D231	R:R:N233	4.04	No	No	0	5	3
136	R:R:D231	R:R:F234	5.97	No	No	0	5	7
137	R:R:D232	R:R:N233	10.77	No	No	0	4	3
138	R:R:N343	R:R:V235	4.43	Yes	No	0	7	6
139	R:R:L236	R:R:V347	2.98	No	No	0	6	5
140	R:R:F340	R:R:S239	7.93	Yes	No	0	7	6
141	R:R:F240	R:R:F244	7.5	No	No	0	4	5
142	R:R:F240	R:R:I245	2.51	No	No	0	4	5
143	R:R:F243	R:R:F244	6.43	Yes	No	0	8	5
144	R:R:F243	R:R:F332	3.22	Yes	No	1	8	9
145	R:R:F243	R:R:W336	3.01	Yes	Yes	1	8	8
146	R:R:F243	R:R:F340	17.15	Yes	Yes	1	8	7
147	R:R:I245	R:R:P246	3.39	No	No	0	5	9
148	R:R:F329	R:R:M250	2.49	Yes	No	0	8	8
149	R:R:F332	R:R:M250	8.71	No	No	0	9	8
150	R:R:F255	R:R:V251	2.62	No	No	0	1	5
151	R:R:F329	R:R:V251	2.62	Yes	No	0	8	5
152	R:R:I252	R:R:L256	2.85	No	No	0	5	5
153	R:R:G326	R:R:Y254	4.35	No	No	0	6	9
154	R:R:F329	R:R:Y254	5.16	Yes	No	0	8	9
155	R:R:C322	R:R:I258	3.27	No	No	0	7	5
156	R:R:E318	R:R:L261	6.63	No	No	0	8	8
157	R:R:I315	R:R:Q319	4.12	No	No	0	5	5
158	R:R:K320	R:R:S316	4.59	No	No	0	8	6
159	R:R:K320	R:R:N317	2.8	No	No	0	8	6
160	R:R:F383	R:R:V324	6.55	No	No	0	7	8
161	R:R:V328	R:R:Y380	3.79	No	Yes	0	8	9
162	R:R:F329	R:R:F330	5.36	Yes	No	0	8	5
163	R:R:F329	R:R:V333	5.24	Yes	No	0	8	6
164	R:R:L331	R:R:M335	4.24	No	No	0	6	8
165	R:R:F332	R:R:W336	8.02	No	Yes	1	9	8
166	R:R:M335	R:R:S372	9.2	No	No	0	8	9
167	R:R:M335	R:R:V375	3.04	No	No	0	8	6
168	R:R:F340	R:R:W336	6.01	Yes	Yes	1	7	8
169	R:R:G369	R:R:W336	2.81	No	Yes	0	7	8
170	R:R:S372	R:R:W336	3.71	No	Yes	0	9	8
171	R:R:C337	R:R:I341	3.27	No	No	0	6	6
172	R:R:F365	R:R:P338	8.67	Yes	No	0	5	9
173	R:R:F339	R:R:F340	9.65	Yes	Yes	1	7	7
174	R:R:F339	R:R:N343	3.62	Yes	Yes	1	7	7
175	R:R:F339	R:R:F365	3.22	Yes	Yes	0	7	5
176	R:R:F339	R:R:V366	5.24	Yes	No	0	7	6
177	R:R:L362	R:R:T342	4.42	No	No	0	3	5
178	R:R:F365	R:R:T342	10.38	Yes	No	0	5	5
179	R:R:L362	R:R:N343	4.12	No	Yes	0	3	7
180	R:R:C349	R:R:C353	7.28	No	No	0	3	3
181	R:R:E351	R:R:K350	4.05	No	No	0	5	1
182	R:R:E355	R:R:I358	4.1	No	No	0	3	4
183	R:R:L361	R:R:V357	4.47	No	No	0	4	5
184	R:R:I358	R:R:L361	2.85	No	No	0	4	4
185	R:R:F365	R:R:L361	4.87	Yes	No	0	5	4
186	R:R:F365	R:R:V364	2.62	Yes	No	0	5	4
187	R:R:F365	R:R:I368	2.51	Yes	No	0	5	7
188	R:R:W367	R:R:Y370	4.82	No	No	0	6	7
189	R:R:I368	R:R:L371	2.85	No	No	0	7	4
190	R:R:N376	R:R:S372	2.98	No	No	0	9	9
191	R:R:L378	R:R:L382	4.15	No	No	0	6	5
192	R:R:V379	R:R:Y380	2.52	No	Yes	0	8	9
193	R:R:L382	R:R:T381	4.42	No	No	0	5	7
194	R:R:T381	R:R:Y387	7.49	No	Yes	0	7	8
195	R:R:F391	R:R:L382	4.87	Yes	No	0	6	5
196	R:R:N384	R:R:T386	8.77	No	Yes	0	9	6
197	R:R:K385	R:R:R388	14.85	No	No	0	5	9
198	R:R:K385	R:R:S389	7.65	No	No	0	5	4
199	R:R:F125	R:R:L126	2.44	No	No	0	4	5
200	R:R:F243	R:R:L247	2.44	Yes	No	0	8	6
201	R:R:L325	R:R:R173	2.43	No	No	0	8	9
202	R:R:I135	R:R:W367	2.35	No	No	0	5	6
203	R:R:A90	R:R:G91	1.95	No	No	0	4	8
204	R:R:C337	R:R:P338	1.88	No	No	0	6	9
205	R:R:G205	R:R:V204	1.84	No	No	0	4	4
206	R:R:A390	R:R:A98	1.79	No	No	0	7	7
207	R:R:A108	R:R:A192	1.79	No	No	0	5	7
208	R:R:G238	R:R:I237	1.76	No	No	0	6	4
209	L:L:?1	R:R:G238	1.74	Yes	No	0	0	6
210	R:R:A117	R:R:V95	1.7	No	No	0	9	9
211	R:R:M128	R:R:P129	1.68	Yes	No	0	8	8
212	R:R:N179	R:R:P180	1.63	Yes	No	0	6	8
213	R:R:C167	R:R:M250	1.62	No	No	0	6	8
214	R:R:C349	R:R:M345	1.62	No	No	0	3	4
215	R:R:A78	R:R:M132	1.61	No	No	0	6	6
216	R:R:V235	R:R:V347	1.6	No	No	0	6	5
217	R:R:V324	R:R:V328	1.6	No	No	0	8	8
218	R:R:T88	R:R:V84	1.59	No	No	0	7	7
219	R:R:T134	R:R:V130	1.59	No	No	0	5	4
220	R:R:A149	R:R:L215	1.58	No	No	0	6	5
221	R:R:A321	R:R:L261	1.58	No	No	0	8	8
222	R:R:I202	R:R:S203	1.55	No	No	0	5	8
223	R:R:I315	R:R:S316	1.55	No	No	0	5	6
224	R:R:I206	R:R:V241	1.54	No	No	0	6	4
225	R:R:I237	R:R:V241	1.54	No	No	0	4	4
226	R:R:I177	R:R:T257	1.52	No	No	0	9	9
227	R:R:I252	R:R:T248	1.52	No	No	0	5	3
228	R:R:C353	R:R:E355	1.52	No	No	0	3	3
229	R:R:F222	R:R:G225	1.51	No	No	0	2	3
230	R:R:L101	R:R:S100	1.5	No	No	0	5	1
231	R:R:L166	R:R:S162	1.5	No	No	0	8	9
232	R:R:L87	R:R:V83	1.49	No	No	0	4	4
233	R:R:N179	R:R:V175	1.48	Yes	No	0	6	5
234	R:R:L113	R:R:T381	1.47	No	No	0	8	7
235	R:R:D217	R:R:S219	1.47	No	No	0	4	3
236	R:R:I344	R:R:I348	1.47	No	No	0	5	4
237	R:R:I93	R:R:M97	1.46	No	No	0	3	4
238	R:R:I118	R:R:M114	1.46	No	No	0	6	5
239	R:R:I327	R:R:K323	1.45	No	No	0	6	7
240	R:R:E351	R:R:S352	1.44	No	No	0	5	2
241	R:R:I177	R:R:L261	1.43	No	No	0	9	8
242	R:R:I344	R:R:L236	1.43	No	No	0	5	6
243	R:R:K385	R:R:N384	1.4	No	No	0	5	9
244	R:R:L79	R:R:L80	1.38	No	No	0	4	4
245	R:R:E318	R:R:N317	1.31	No	No	0	8	6
246	R:R:N187	R:R:R189	1.21	No	No	0	6	4
247	R:R:I258	R:R:Y254	1.21	No	No	0	5	9
248	R:R:Q106	R:R:Y111	1.13	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.687	10	1	0
2	R:R:L105	7.0725	4	3	8
3	R:R:N110	5.865	4	3	9
4	R:R:F112	5.91833	6	2	8
5	R:R:M121	5.17	4	0	7
6	R:R:L123	4.855	4	0	7
7	R:R:V127	5.73	4	1	8
8	R:R:M128	3.9525	4	0	8
9	R:R:W141	5.66333	6	1	7
10	R:R:C148	6.0075	4	1	9
11	R:R:W151	10.47	4	1	5
12	R:R:T160	5.37	4	1	7
13	R:R:H165	7.162	5	2	8
14	R:R:Y174	5.6125	4	0	8
15	R:R:N179	2.735	4	0	6
16	R:R:W200	4.1775	4	2	9
17	R:R:F243	6.45	5	1	8
18	R:R:F329	4.174	5	0	8
19	R:R:W336	4.712	5	1	8
20	R:R:F339	7.316	5	1	7
21	R:R:F340	10.376	5	1	7
22	R:R:N343	4.09	4	1	7
23	R:R:F365	5.37833	6	0	5
24	R:R:Y380	4.7	5	2	9
25	R:R:T386	7.3325	4	3	6
26	R:R:Y387	6.9075	4	3	8
27	R:R:F391	5.025	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	100	6.89	Yes	No	1	0	8
2	R:R:D155	R:R:Y370	11.8438	10.34	No	No	1	8	7
3	R:R:W367	R:R:Y370	15.1552	4.82	No	No	0	6	7
4	R:R:D155	R:R:V127	87.5125	7.3	No	Yes	1	8	8
5	R:R:L123	R:R:V127	75.7688	4.47	Yes	Yes	0	7	8
6	R:R:G124	R:R:L123	12.3587	3.42	No	Yes	0	6	7
7	R:R:G124	R:R:M128	10.6351	5.24	No	Yes	0	6	8
8	R:R:F158	R:R:L123	65.663	8.53	No	Yes	0	7	7
9	R:R:F158	R:R:L122	63.2599	3.65	No	No	0	7	7
10	R:R:L122	R:R:L126	62.0369	2.77	No	No	0	7	5
11	R:R:F125	R:R:L126	60.7996	2.44	No	No	0	4	5
12	R:R:F125	R:R:M121	59.548	4.98	No	Yes	0	4	7
13	R:R:I96	R:R:M121	51.7308	2.92	No	Yes	0	6	7
14	R:R:I96	R:R:M114	50.5865	5.83	No	No	0	6	5
15	R:R:M114	R:R:V99	47.8186	3.04	No	No	0	5	7
16	R:R:V99	R:R:Y387	46.3954	3.79	No	Yes	0	7	8
17	R:R:T381	R:R:Y387	17.3723	7.49	No	Yes	0	7	8
18	R:R:L382	R:R:T381	14.0109	4.42	No	No	0	5	7
19	R:R:F391	R:R:L382	10.5779	4.87	Yes	No	0	6	5
20	R:R:L105	R:R:Y387	25.2682	8.21	Yes	Yes	3	8	8
21	R:R:E102	R:R:R393	10.4205	4.65	No	No	0	6	4
22	R:R:L105	R:R:T386	15.427	10.32	Yes	Yes	3	8	6
23	L:L:?1	R:R:T160	32.22	5.99	Yes	Yes	1	0	7
24	R:R:M164	R:R:T160	28.5295	3.01	No	Yes	0	6	7
25	R:R:M164	R:R:S203	25.025	3.07	No	No	0	6	8
26	R:R:A161	R:R:S203	22.2786	3.42	No	No	0	8	8
27	R:R:A161	R:R:W200	20.8983	3.89	No	Yes	0	8	9
28	R:R:H165	R:R:W200	15.5915	5.29	Yes	Yes	2	8	9
29	R:R:F112	R:R:H165	13.9322	10.18	Yes	Yes	2	8	8
30	L:L:?1	R:R:F340	81.5191	11.14	Yes	Yes	1	0	7
31	R:R:F340	R:R:W336	56.4798	6.01	Yes	Yes	1	7	8
32	R:R:S372	R:R:W336	26.2194	3.71	No	Yes	0	9	8
33	R:R:N376	R:R:S372	21.6421	2.98	No	No	0	9	9
34	R:R:L166	R:R:N376	20.4763	5.49	No	No	0	8	9
35	R:R:L166	R:R:Y380	18.1233	7.03	No	Yes	0	8	9
36	R:R:I169	R:R:Y380	10.1345	6.04	No	Yes	2	9	9
37	R:R:F112	R:R:K195	15.5486	12.41	Yes	No	0	8	6
38	R:R:V127	R:R:W151	29.3878	7.36	Yes	Yes	1	8	5
39	R:R:W141	R:R:W151	23.2013	7.5	Yes	Yes	1	7	5
40	L:L:?1	R:R:V156	17.4439	6.05	Yes	No	0	0	6
41	R:R:S207	R:R:V156	15.7631	3.23	No	No	0	7	6
42	R:R:F243	R:R:F340	42.3831	17.15	Yes	Yes	1	8	7
43	R:R:F243	R:R:F332	40.0229	3.22	Yes	No	1	8	9
44	R:R:F332	R:R:M250	85.1953	8.71	No	No	0	9	8
45	R:R:C167	R:R:M250	63.31	1.62	No	No	0	6	8
46	R:R:F332	R:R:W336	47.3037	8.02	No	Yes	1	9	8
47	R:R:C167	R:R:I249	61.0213	3.27	No	No	0	6	6
48	R:R:I249	R:R:L171	58.7184	2.85	No	No	0	6	6
49	R:R:L171	R:R:T253	56.6943	2.95	No	No	0	6	5
50	R:R:T253	R:R:Y174	52.0169	2.5	No	Yes	0	5	8
51	R:R:Q178	R:R:Y174	18.2163	9.02	No	Yes	0	6	8
52	R:R:T257	R:R:Y174	25.2682	6.24	No	Yes	0	9	8
53	R:R:K191	R:R:K195	12.5948	2.87	No	No	0	6	6
54	R:R:N179	R:R:Q178	13.0811	5.28	Yes	No	0	6	6
55	L:L:?1	R:R:N343	11.901	4.19	Yes	Yes	1	0	7
56	R:R:N343	R:R:V235	12.0154	4.43	Yes	No	0	7	6
57	R:R:F329	R:R:M250	23.2513	2.49	Yes	No	0	8	8
58	R:R:F329	R:R:Y254	10.4706	5.16	Yes	No	0	8	9
59	R:R:I177	R:R:T257	22.7507	1.52	No	No	0	9	9
60	R:R:I177	R:R:L261	20.2189	1.43	No	No	0	9	8
61	R:R:E318	R:R:L261	15.3769	6.63	No	No	0	8	8
62	R:R:E318	R:R:N317	13.0811	1.31	No	No	0	8	6
63	R:R:K320	R:R:N317	10.4921	2.8	No	No	0	8	6
64	L:L:?1	R:R:F339	15.9419	14.85	Yes	Yes	1	0	7
65	R:R:F339	R:R:F365	26.5413	3.22	Yes	Yes	0	7	5
66	R:R:F365	R:R:L361	12.7163	4.87	Yes	No	0	5	4
67	R:R:F339	R:R:F340	17.9159	9.65	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	6.89	1	Yes	No	0	8	0	1
L:L:?1	R:R:V156	6.05	1	Yes	No	0	6	0	1
L:L:?1	R:R:S159	15.25	1	Yes	No	0	7	0	1
L:L:?1	R:R:T160	5.99	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F234	6.19	1	Yes	No	0	7	0	1
L:L:?1	R:R:S242	4.58	1	Yes	No	0	6	0	1
L:L:?1	R:R:F339	14.85	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	11.14	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N343	4.19	1	Yes	Yes	0	7	0	1
R:R:D155	R:R:V127	7.3	1	No	Yes	8	8	1	2
R:R:V127	R:R:Y370	3.79	1	Yes	No	8	7	2	2
R:R:D155	R:R:Y370	10.34	1	No	No	8	7	1	2
R:R:S207	R:R:V156	3.23	4	No	No	7	6	2	1
R:R:M164	R:R:T160	3.01	0	No	Yes	6	7	2	1
R:R:I206	R:R:T160	6.08	0	No	Yes	6	7	2	1
R:R:S242	R:R:T160	6.4	1	No	Yes	6	7	1	1
R:R:D231	R:R:F234	5.97	0	No	No	5	7	2	1
R:R:N343	R:R:V235	4.43	1	Yes	No	7	6	1	2
R:R:F340	R:R:S239	7.93	1	Yes	No	7	6	1	2
R:R:F243	R:R:W336	3.01	1	Yes	Yes	8	8	2	2
R:R:F243	R:R:F340	17.15	1	Yes	Yes	8	7	2	1
R:R:F340	R:R:W336	6.01	1	Yes	Yes	7	8	1	2
R:R:F339	R:R:F340	9.65	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	3.62	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:F365	3.22	1	Yes	Yes	7	5	1	2
R:R:F339	R:R:V366	5.24	1	Yes	No	7	6	1	2
R:R:L362	R:R:N343	4.12	0	No	Yes	3	7	2	1
R:R:G238	R:R:I237	1.76	0	No	No	6	4	1	2
L:L:?1	R:R:G238	1.74	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LLA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.49
Number of Linked Nodes	240
Number of Links	248
Number of Hubs	27
Number of Links mediated by Hubs	107
Number of Communities	4
Number of Nodes involved in Communities	36
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	28791
Length Of Smallest Path	3
Average Path Length	14.2689
Length of Longest Path	37
Minimum Path Strength	1.45
Average Path Strength	5.4534
Maximum Path Strength	15.05
Minimum Path Correlation	0.7
Average Path Correlation	0.92087
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	48.4419
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.9405
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein tyrosine kinase activator activity • enzyme regulator activity • kinase activator activity • enzyme activator activity • molecular function activator activity • molecular function regulator activity • protein kinase activator activity • protein kinase regulator activity • kinase regulator activity • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • Gq/11-coupled serotonin receptor activity • protein-containing complex binding • binding • identical protein binding • protein binding • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • virus receptor activity • exogenous protein binding • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • localization • protein localization to cytoskeleton • protein localization to organelle • macromolecule localization • intracellular protein localization • regulation of lipid metabolic process • glycerophospholipid metabolic process • lipid biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • phospholipid metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • positive regulation of lipid metabolic process • positive regulation of phosphatidylinositol biosynthetic process • phosphorus metabolic process • positive regulation of cellular process • regulation of phosphatidylinositol biosynthetic process • regulation of biosynthetic process • phosphatidylinositol metabolic process • positive regulation of phosphorus metabolic process • glycerophospholipid biosynthetic process • positive regulation of phospholipid biosynthetic process • regulation of phospholipid metabolic process • primary metabolic process • phospholipid biosynthetic process • regulation of phospholipid biosynthetic process • phosphatidylinositol biosynthetic process • positive regulation of phospholipid metabolic process • biosynthetic process • positive regulation of lipid biosynthetic process • glycerolipid biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • metabolic process • regulation of phosphorus metabolic process • glycerolipid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • neuron apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • positive regulation of neuron apoptotic process • programmed cell death • regulation of neuron apoptotic process • behavior • learning or memory • nervous system process • cognition • memory • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • regulation of body fluid levels • homotypic cell-cell adhesion • regulation of cell activation • positive regulation of cell-cell adhesion • cell adhesion • cell-cell adhesion • coagulation • regulation of cell-cell adhesion • response to wounding • wound healing • regulation of homotypic cell-cell adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • regulation of platelet activation • regulation of platelet aggregation • positive regulation of homotypic cell-cell adhesion • positive regulation of platelet aggregation • platelet activation • ribonucleotide catabolic process • pyridine nucleotide catabolic process • aerobic respiration • oxoacid metabolic process • carbohydrate catabolic process • carbohydrate derivative metabolic process • organophosphate catabolic process • nucleoside phosphate catabolic process • organic acid metabolic process • nucleobase-containing compound metabolic process • glycolytic process • pyridine-containing compound metabolic process • small molecule metabolic process • purine ribonucleotide catabolic process • nucleoside phosphate metabolic process • nicotinamide nucleotide metabolic process • pyruvate metabolic process • purine nucleoside diphosphate metabolic process • purine-containing compound catabolic process • nucleotide metabolic process • nucleobase-containing compound catabolic process • nucleoside diphosphate metabolic process • purine nucleoside diphosphate catabolic process • nucleoside diphosphate catabolic process • nucleoside triphosphate metabolic process • monocarboxylic acid metabolic process • purine ribonucleotide metabolic process • pyridine-containing compound catabolic process • ribose phosphate metabolic process • cellular respiration • catabolic process • ATP metabolic process • energy derivation by oxidation of organic compounds • purine nucleotide metabolic process • ribonucleotide metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • ribonucleoside diphosphate metabolic process • ribonucleoside diphosphate catabolic process • nucleotide catabolic process • purine nucleoside triphosphate metabolic process • purine nucleotide catabolic process • carbohydrate metabolic process • carbohydrate derivative catabolic process • ADP catabolic process • carboxylic acid metabolic process • generation of precursor metabolites and energy • purine-containing compound metabolic process • ADP metabolic process • purine ribonucleoside diphosphate metabolic process • purine ribonucleoside diphosphate catabolic process • detection of external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • negative regulation of signaling • synaptic transmission, glutamatergic • negative regulation of biological process • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • negative regulation of synaptic transmission, glutamatergic • smooth muscle contraction • urinary bladder smooth muscle contraction • urinary tract smooth muscle contraction • muscle contraction • muscle system process • developmental process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of potassium ion transport • regulation of localization • regulation of potassium ion transport • transport • regulation of transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • negative regulation of transport • establishment of localization • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of cytosolic calcium ion concentration • regulation of heat generation • positive regulation of heat generation • heat generation • multicellular organismal-level homeostasis • temperature homeostasis • regulation of generation of precursor metabolites and energy • regulation of ATP metabolic process • regulation of purine nucleotide catabolic process • positive regulation of nucleotide catabolic process • regulation of small molecule metabolic process • regulation of nucleotide metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of carbohydrate catabolic process • regulation of purine nucleotide metabolic process • positive regulation of ATP metabolic process • regulation of nucleotide catabolic process • positive regulation of carbohydrate metabolic process • positive regulation of nucleotide metabolic process • positive regulation of purine nucleotide catabolic process • regulation of carbohydrate metabolic process • positive regulation of glycolytic process • regulation of catabolic process • regulation of glycolytic process • positive regulation of purine nucleotide metabolic process • positive regulation of catabolic process • positive regulation of small molecule metabolic process • adult behavior • behavioral response to cocaine • response to oxygen-containing compound • response to nitrogen compound • response to cocaine • response to alkaloid • detection of mechanical stimulus involved in sensory perception of pain • response to mechanical stimulus • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • learning • nonassociative learning • sensitization • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • organic hydroxy compound transport • dopamine transport • secretion by cell • regulation of secretion by cell • catecholamine transport • signal release • secretion • export from cell • dopamine secretion • regulation of secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • calcium ion transmembrane import into cytosol • monoatomic ion transmembrane transport • calcium ion transport • monoatomic cation transmembrane transport • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • vascular associated smooth muscle contraction • artery smooth muscle contraction • tonic smooth muscle contraction • regulation of DNA biosynthetic process • positive regulation of macromolecule biosynthetic process • nucleic acid biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of DNA biosynthetic process • regulation of macromolecule metabolic process • DNA metabolic process • nucleobase-containing compound biosynthetic process • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of DNA metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • DNA biosynthetic process • regulation of DNA metabolic process • regulation of immune effector process • cytokine production • regulation of cytokine production • positive regulation of immune effector process • regulation of immune system process • cytokine production involved in immune response • positive regulation of immune system process • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune response • gene expression • immune effector process • regulation of gene expression • positive regulation of gene expression • immune system process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • positive regulation of cytokine production • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • presynapse
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • glutamatergic synapse • dendritic shaft • cell body • neuronal cell body • axon • membrane microdomain • membrane raft • plasma membrane raft • caveola • cell body fiber • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • cytoplasmic vesicle • organelle • intracellular vesicle • cytoplasm • intracellular membrane-bounded organelle • vesicle • polymeric cytoskeletal fiber • neurofilament • intracellular membraneless organelle • intermediate filament cytoskeleton • cytoskeleton • membraneless organelle • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D1 dopamine receptor binding • dopamine receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • response to endogenous stimulus • hormone-mediated signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • system process • sensory perception • nervous system process • sensory perception of itch • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of chemical stimulus • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • homotypic cell-cell adhesion • platelet aggregation • cell adhesion • cell-cell adhesion • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • cellular response to ketone • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • nuclear membrane • nucleus • endomembrane system • organelle envelope • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • postsynaptic cytosol • cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • midbody • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • centrosome • microtubule organizing center • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • photoreceptor disc membrane
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9LLA_nogp_Chain_R S A L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.54	2025-04-02	10.1038/s41467-025-57956-7
	9AS8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.54	2025-04-02	10.1038/s41467-025-57956-7
	9LL9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.76	2026-01-14	To be published
	9LL9 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.76	2026-01-14	To be published
	9LLA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.27	2026-01-14	To be published
	9LLA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-		3.27	2026-01-14	To be published
	9LLB	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.98	2026-01-14	To be published
	9LLB (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-		2.98	2026-01-14	To be published
	9LL7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	Gi1/β1/γ2	2.84	2026-01-14	To be published
	9LL7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.84	2026-01-14	To be published
	9LL8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	Gi1/β1/γ2	2.62	2026-01-14	To be published
	9LL8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.62	2026-01-14	To be published

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