psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	8.72	Yes	No	0	0	8
2	L:L:?1	R:R:V156	11.17	Yes	No	0	0	6
3	L:L:?1	R:R:S159	16.08	Yes	No	0	0	7
4	L:L:?1	R:R:L229	4.45	Yes	No	0	0	4
5	L:L:?1	R:R:S242	3.22	Yes	No	0	0	6
6	L:L:?1	R:R:F339	16.96	Yes	Yes	2	0	7
7	L:L:?1	R:R:F340	10.43	Yes	Yes	2	0	7
8	L:L:?1	R:R:N343	7.35	Yes	No	0	0	7
9	R:R:M132	R:R:T81	6.02	No	No	0	6	6
10	R:R:T81	R:R:W367	10.92	No	Yes	0	6	6
11	R:R:V84	R:R:W367	3.68	No	Yes	0	7	6
12	R:R:I85	R:R:M128	4.37	No	Yes	0	6	8
13	R:R:M128	R:R:T88	6.02	Yes	No	0	8	7
14	R:R:A374	R:R:T88	5.03	No	No	0	6	7
15	R:R:F125	R:R:I89	7.54	No	No	0	4	5
16	R:R:D120	R:R:N92	6.73	Yes	No	0	9	9
17	R:R:M121	R:R:N92	5.61	Yes	No	0	7	9
18	R:R:N92	R:R:P377	6.52	No	No	0	9	9
19	R:R:F391	R:R:L94	3.65	Yes	No	0	6	6
20	R:R:A117	R:R:V95	3.39	No	Yes	0	9	9
21	R:R:P377	R:R:V95	3.53	No	Yes	0	9	9
22	R:R:F391	R:R:V95	3.93	Yes	Yes	0	6	9
23	R:R:V99	R:R:Y387	3.79	No	Yes	0	7	8
24	R:R:A390	R:R:E102	6.03	No	No	0	7	6
25	R:R:E102	R:R:R393	5.82	No	No	0	6	4
26	R:R:K103	R:R:Q106	8.14	No	No	0	6	7
27	R:R:L105	R:R:N110	4.12	No	No	3	8	9
28	R:R:L105	R:R:T386	8.84	No	No	0	8	6
29	R:R:L105	R:R:Y387	17.58	No	Yes	3	8	8
30	R:R:Q106	R:R:Y111	5.64	No	No	0	7	4
31	R:R:N107	R:R:N110	8.17	No	No	0	7	9
32	R:R:N110	R:R:Y387	10.47	No	Yes	3	9	8
33	R:R:F112	R:R:H165	9.05	Yes	Yes	0	8	8
34	R:R:F112	R:R:I169	5.02	Yes	No	0	8	9
35	R:R:F112	R:R:K195	16.13	Yes	No	0	8	6
36	R:R:H165	R:R:S115	6.97	Yes	No	4	8	9
37	R:R:I196	R:R:S115	6.19	No	No	0	8	9
38	R:R:S115	R:R:W200	4.94	No	Yes	4	9	9
39	R:R:D120	R:R:L116	5.43	Yes	No	0	9	9
40	R:R:H165	R:R:L116	7.71	Yes	No	0	8	9
41	R:R:D120	R:R:S162	4.42	Yes	No	0	9	9
42	R:R:D120	R:R:S373	4.42	Yes	No	0	9	9
43	R:R:D120	R:R:N376	6.73	Yes	No	0	9	9
44	R:R:F125	R:R:M121	3.73	No	Yes	0	4	7
45	R:R:F158	R:R:L122	7.31	Yes	No	0	7	7
46	R:R:L123	R:R:V127	4.47	No	No	0	7	8
47	R:R:F158	R:R:L123	9.74	Yes	No	0	7	7
48	R:R:G124	R:R:M128	5.24	No	Yes	0	6	8
49	R:R:L126	R:R:L154	4.15	No	No	0	5	5
50	R:R:V127	R:R:W151	9.81	No	Yes	0	8	5
51	R:R:D155	R:R:V127	7.3	No	No	0	8	8
52	R:R:M128	R:R:Y370	10.78	Yes	Yes	0	8	7
53	R:R:V130	R:R:W141	3.68	No	Yes	1	4	7
54	R:R:V130	R:R:W151	13.48	No	Yes	1	4	5
55	R:R:S131	R:R:W151	3.71	Yes	Yes	1	7	5
56	R:R:S131	R:R:W367	4.94	Yes	Yes	1	7	6
57	R:R:S131	R:R:Y370	3.82	Yes	Yes	1	7	7
58	R:R:I135	R:R:Y139	4.84	No	No	0	5	3
59	R:R:I135	R:R:W367	5.87	No	Yes	0	5	6
60	R:R:P142	R:R:Y137	5.56	No	No	0	3	4
61	R:R:N363	R:R:Y139	16.28	No	No	0	4	3
62	R:R:P142	R:R:W141	5.4	No	Yes	1	3	7
63	R:R:L143	R:R:W141	10.25	No	Yes	1	5	7
64	R:R:W141	R:R:W151	7.5	Yes	Yes	1	7	5
65	R:R:F222	R:R:W141	4.01	Yes	Yes	0	2	7
66	R:R:C227	R:R:W141	14.37	Yes	Yes	1	9	7
67	R:R:L143	R:R:P142	4.93	No	No	1	5	3
68	R:R:L147	R:R:P144	4.93	No	No	0	5	7
69	R:R:D218	R:R:S145	4.42	No	No	0	3	3
70	R:R:C148	R:R:V221	5.12	No	No	0	9	3
71	R:R:C148	R:R:F222	8.38	No	Yes	0	9	2
72	R:R:C148	R:R:C227	7.28	No	Yes	0	9	9
73	R:R:C227	R:R:W151	5.22	Yes	Yes	1	9	5
74	R:R:I152	R:R:I210	4.42	No	Yes	0	5	6
75	R:R:C227	R:R:I152	3.27	Yes	No	0	9	5
76	R:R:I152	R:R:L229	5.71	No	No	0	5	4
77	R:R:S207	R:R:Y153	7.63	No	No	0	7	6
78	R:R:P211	R:R:Y153	9.74	No	No	0	5	6
79	R:R:F158	R:R:L154	4.87	Yes	No	0	7	5
80	R:R:D155	R:R:Y370	6.9	No	Yes	0	8	7
81	R:R:S207	R:R:V156	4.85	No	No	0	7	6
82	R:R:I210	R:R:V156	4.61	Yes	No	0	6	6
83	R:R:F158	R:R:L157	3.65	Yes	No	0	7	6
84	R:R:L157	R:R:S207	4.5	No	No	0	6	7
85	R:R:S203	R:R:T160	6.4	No	No	0	8	7
86	R:R:I206	R:R:T160	6.08	No	No	0	6	7
87	R:R:S242	R:R:T160	4.8	No	No	0	6	7
88	R:R:A161	R:R:W200	3.89	No	Yes	0	8	9
89	R:R:A161	R:R:S203	3.42	No	No	0	8	8
90	R:R:I163	R:R:P246	3.39	No	Yes	0	8	9
91	R:R:I163	R:R:W336	5.87	No	Yes	0	8	8
92	R:R:I202	R:R:M164	4.37	No	No	0	5	6
93	R:R:M164	R:R:P246	3.35	No	Yes	0	6	9
94	R:R:H165	R:R:V199	8.3	Yes	No	0	8	6
95	R:R:H165	R:R:W200	5.29	Yes	Yes	4	8	9
96	R:R:L166	R:R:N376	9.61	No	No	0	8	9
97	R:R:L166	R:R:Y380	4.69	No	Yes	0	8	9
98	R:R:C167	R:R:P246	3.77	No	Yes	0	6	9
99	R:R:C167	R:R:I249	4.91	No	No	0	6	6
100	R:R:I169	R:R:R173	5.01	No	No	0	9	9
101	R:R:M250	R:R:S170	6.13	No	No	0	8	9
102	R:R:S170	R:R:T253	6.4	No	No	0	9	5
103	R:R:I249	R:R:L171	4.28	No	No	0	6	6
104	R:R:D172	R:R:H183	5.04	No	Yes	0	9	7
105	R:R:D172	R:R:K191	4.15	No	No	0	9	6
106	R:R:D172	R:R:K195	6.91	No	No	0	9	6
107	R:R:R173	R:R:Y380	7.2	No	Yes	0	9	9
108	R:R:Q178	R:R:Y174	11.27	No	Yes	0	6	8
109	R:R:L256	R:R:Y174	7.03	No	Yes	0	5	8
110	R:R:T257	R:R:Y174	6.24	No	Yes	0	9	8
111	R:R:A176	R:R:H183	7.32	No	Yes	0	8	7
112	R:R:I177	R:R:T257	4.56	No	No	0	9	9
113	R:R:I177	R:R:L261	5.71	No	Yes	0	9	8
114	R:R:N179	R:R:Q178	9.24	No	No	0	6	6
115	R:R:Q178	R:R:S260	4.33	No	No	0	6	6
116	R:R:F186	R:R:H182	10.18	No	No	0	4	5
117	R:R:H183	R:R:N187	5.1	Yes	No	0	7	6
118	R:R:F186	R:R:R185	7.48	No	No	0	4	4
119	R:R:K191	R:R:N187	6.99	No	No	0	6	6
120	R:R:S188	R:R:T190	4.8	No	No	0	7	5
121	R:R:M208	R:R:P209	3.35	No	No	0	4	7
122	R:R:F234	R:R:P209	7.22	No	No	0	7	7
123	R:R:I210	R:R:P211	3.39	Yes	No	0	6	5
124	R:R:F234	R:R:I210	6.28	No	Yes	0	7	6
125	R:R:F213	R:R:V212	11.8	No	No	0	4	5
126	R:R:F213	R:R:Q216	12.88	No	No	0	4	6
127	R:R:D217	R:R:Q216	9.14	No	No	0	4	6
128	R:R:D217	R:R:K220	4.15	No	No	0	4	3
129	R:R:K223	R:R:L228	7.05	No	No	0	3	4
130	R:R:F234	R:R:L229	3.65	No	No	0	7	4
131	R:R:D232	R:R:V347	7.3	No	No	0	4	5
132	R:R:N343	R:R:V235	4.43	No	No	0	7	6
133	R:R:V235	R:R:V347	4.81	No	No	0	6	5
134	R:R:L236	R:R:V347	5.96	No	No	0	6	5
135	R:R:I344	R:R:S239	4.64	No	No	0	5	6
136	R:R:F240	R:R:I245	3.77	No	No	0	4	5
137	R:R:F243	R:R:F244	9.65	Yes	No	0	8	5
138	R:R:F243	R:R:F332	3.22	Yes	Yes	2	8	9
139	R:R:F243	R:R:W336	4.01	Yes	Yes	2	8	8
140	R:R:F243	R:R:F340	25.72	Yes	Yes	2	8	7
141	R:R:F244	R:R:I344	3.77	No	No	0	5	5
142	R:R:I245	R:R:P246	3.39	No	Yes	0	5	9
143	R:R:F332	R:R:M250	11.2	Yes	No	0	9	8
144	R:R:F329	R:R:V251	3.93	No	No	0	8	5
145	R:R:I258	R:R:Y254	10.88	No	Yes	0	5	9
146	R:R:G326	R:R:Y254	4.35	No	Yes	0	6	9
147	R:R:F329	R:R:Y254	20.63	No	Yes	0	8	9
148	R:R:I258	R:R:Q262	4.12	No	No	0	5	6
149	R:R:C322	R:R:I258	3.27	No	No	0	7	5
150	R:R:E318	R:R:L261	6.63	No	Yes	0	8	8
151	R:R:C322	R:R:L261	4.76	No	Yes	0	7	8
152	R:R:E318	R:R:I315	13.66	No	No	0	8	5
153	R:R:I315	R:R:Q319	4.12	No	No	0	5	5
154	R:R:I327	R:R:K323	8.72	No	No	0	6	7
155	R:R:F383	R:R:V324	10.49	No	No	0	7	8
156	R:R:V328	R:R:Y380	3.79	No	Yes	0	8	9
157	R:R:F329	R:R:V333	5.24	No	No	0	8	6
158	R:R:F330	R:R:V334	7.87	No	No	0	5	5
159	R:R:L331	R:R:V379	4.47	No	No	0	6	8
160	R:R:F332	R:R:W336	7.02	Yes	Yes	2	9	8
161	R:R:L371	R:R:M335	4.24	No	Yes	0	4	8
162	R:R:M335	R:R:S372	10.73	Yes	No	0	8	9
163	R:R:F340	R:R:W336	6.01	Yes	Yes	2	7	8
164	R:R:G369	R:R:W336	5.63	No	Yes	0	7	8
165	R:R:S372	R:R:W336	4.94	No	Yes	0	9	8
166	R:R:F365	R:R:P338	8.67	No	No	0	5	9
167	R:R:F339	R:R:F340	10.72	Yes	Yes	2	7	7
168	R:R:F339	R:R:V366	3.93	Yes	No	0	7	6
169	R:R:L362	R:R:T342	4.42	No	No	0	3	5
170	R:R:F365	R:R:T342	9.08	No	No	0	5	5
171	R:R:C349	R:R:S352	3.44	No	No	0	3	2
172	R:R:C349	R:R:C353	3.64	No	No	0	3	3
173	R:R:E355	R:R:K350	8.1	No	No	0	3	1
174	R:R:E351	R:R:E355	3.81	No	No	0	5	3
175	R:R:N354	R:R:V357	7.39	No	No	0	1	5
176	R:R:F365	R:R:L361	4.87	No	No	0	5	4
177	R:R:V366	R:R:W367	3.68	No	Yes	0	6	6
178	R:R:W367	R:R:Y370	13.5	Yes	Yes	1	6	7
179	R:R:L378	R:R:L382	5.54	No	No	0	6	5
180	R:R:T381	R:R:Y387	8.74	No	Yes	0	7	8
181	R:R:F391	R:R:L382	6.09	Yes	No	0	6	5
182	R:R:N384	R:R:T386	8.77	No	No	0	9	6
183	R:R:K385	R:R:R388	13.61	No	No	0	5	9
184	R:R:S131	R:R:T134	3.2	Yes	No	0	7	5
185	R:R:T381	R:R:V95	3.17	No	Yes	0	7	9
186	R:R:A149	R:R:L215	3.15	No	No	0	6	5
187	R:R:F255	R:R:Y254	3.09	No	Yes	0	1	9
188	R:R:I237	R:R:V241	3.07	No	No	0	4	4
189	R:R:I245	R:R:V241	3.07	No	No	0	5	4
190	R:R:M114	R:R:V99	3.04	No	No	0	5	7
191	R:R:I252	R:R:T248	3.04	No	No	0	5	3
192	R:R:K104	R:R:T386	3	No	No	0	6	6
193	R:R:L79	R:R:V83	2.98	No	No	0	4	4
194	R:R:I118	R:R:I96	2.94	No	No	0	6	6
195	R:R:I344	R:R:I348	2.94	No	No	0	5	4
196	R:R:I93	R:R:M97	2.92	No	No	0	3	4
197	R:R:I93	R:R:M121	2.92	No	Yes	0	3	7
198	R:R:I96	R:R:M121	2.92	No	Yes	0	6	7
199	R:R:I368	R:R:M335	2.92	No	Yes	0	7	8
200	R:R:I341	R:R:M345	2.92	No	No	0	6	4
201	R:R:F213	R:R:P209	2.89	No	No	0	4	7
202	R:R:I252	R:R:L256	2.85	No	No	0	5	5
203	R:R:I327	R:R:L331	2.85	No	No	0	6	6
204	R:R:I358	R:R:L362	2.85	No	No	0	4	3
205	R:R:K146	R:R:L215	2.82	No	No	0	1	5
206	R:R:C337	R:R:F243	2.79	No	Yes	0	6	8
207	R:R:A98	R:R:F391	2.77	No	Yes	0	7	6
208	R:R:A168	R:R:F112	2.77	No	Yes	0	7	8
209	R:R:H183	R:R:V175	2.77	Yes	No	0	7	5
210	R:R:D231	R:R:K220	2.77	No	No	0	5	3
211	R:R:F222	R:R:S145	2.64	Yes	No	0	2	3
212	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
213	R:R:V379	R:R:Y380	2.52	No	Yes	0	8	9
214	R:R:F244	R:R:I341	2.51	No	No	0	5	6
215	R:R:T253	R:R:Y174	2.5	No	Yes	0	5	8
216	R:R:F383	R:R:K323	2.48	No	No	0	7	7
217	R:R:F243	R:R:L247	2.44	Yes	No	2	8	6
218	R:R:F332	R:R:L247	2.44	Yes	No	2	9	6
219	R:R:F339	R:R:L362	2.44	Yes	No	0	7	3
220	R:R:L325	R:R:Y254	2.34	No	Yes	0	8	9
221	R:R:L147	R:R:W141	2.28	No	Yes	0	5	7
222	R:R:A90	R:R:G91	1.95	No	No	0	4	8
223	R:R:A149	R:R:G214	1.95	No	No	0	6	7
224	R:R:G214	R:R:V221	1.84	No	No	0	7	3
225	R:R:G238	R:R:V241	1.84	No	No	0	6	4
226	R:R:A390	R:R:A98	1.79	No	No	0	7	7
227	R:R:A108	R:R:A192	1.79	No	No	0	5	7
228	R:R:M128	R:R:P129	1.68	Yes	No	0	8	8
229	R:R:C353	R:R:I358	1.64	No	No	0	3	4
230	R:R:N179	R:R:P180	1.63	No	No	0	6	8
231	R:R:A346	R:R:I358	1.62	No	No	0	4	4
232	R:R:V375	R:R:V379	1.6	No	No	0	6	8
233	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
234	R:R:A108	R:R:N187	1.56	No	No	0	5	6
235	R:R:I96	R:R:S100	1.55	No	No	0	6	1
236	R:R:I368	R:R:V364	1.54	No	No	0	7	4
237	R:R:K320	R:R:S316	1.53	No	No	0	8	6
238	R:R:I197	R:R:T201	1.52	No	No	0	2	4
239	R:R:M335	R:R:V334	1.52	Yes	No	0	8	5
240	R:R:F222	R:R:G225	1.51	Yes	No	0	2	3
241	R:R:L101	R:R:S100	1.5	No	No	0	5	1
242	R:R:L154	R:R:V150	1.49	No	No	0	5	4
243	R:R:L157	R:R:V204	1.49	No	No	0	6	4
244	R:R:L113	R:R:T109	1.47	No	No	0	8	8
245	R:R:L113	R:R:T381	1.47	No	No	0	8	7
246	R:R:I237	R:R:N233	1.42	No	No	0	4	3
247	R:R:L133	R:R:M132	1.41	No	No	0	4	6
248	R:R:K385	R:R:N384	1.4	No	No	0	5	9
249	R:R:D356	R:R:N354	1.35	No	No	0	2	1
250	R:R:R393	R:R:S389	1.32	No	No	0	4	4
251	R:R:H182	R:R:N179	1.28	No	No	0	5	6
252	R:R:I181	R:R:R185	1.25	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.7975	8	2	0
2	R:R:V95	3.505	4	0	9
3	R:R:F112	8.2425	4	0	8
4	R:R:D120	5.546	5	0	9
5	R:R:M121	3.795	4	0	7
6	R:R:M128	5.618	5	0	8
7	R:R:S131	3.9175	4	1	7
8	R:R:W141	6.78429	7	1	7
9	R:R:W151	7.944	5	1	5
10	R:R:F158	6.3925	4	0	7
11	R:R:H165	7.464	5	4	8
12	R:R:Y174	6.76	4	0	8
13	R:R:H183	5.0575	4	0	7
14	R:R:W200	4.1775	4	4	9
15	R:R:I210	4.675	4	0	6
16	R:R:F222	4.135	4	0	2
17	R:R:C227	7.535	4	1	9
18	R:R:F243	7.97167	6	2	8
19	R:R:P246	3.475	4	0	9
20	R:R:Y254	8.258	5	0	9
21	R:R:L261	4.67	4	0	8
22	R:R:F332	5.97	4	2	9
23	R:R:M335	4.8525	4	0	8
24	R:R:W336	5.58	6	2	8
25	R:R:F339	8.5125	4	2	7
26	R:R:F340	13.22	4	2	7
27	R:R:W367	7.09833	6	1	6
28	R:R:Y370	8.75	4	1	7
29	R:R:Y380	4.55	4	0	9
30	R:R:Y387	10.145	4	3	8
31	R:R:F391	4.11	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	41.1455	8.72	Yes	No	0	0	8
2	R:R:D155	R:R:Y370	17.5949	6.9	No	Yes	0	8	7
3	L:L:?1	R:R:F339	16.0806	16.96	Yes	Yes	2	0	7
4	R:R:F339	R:R:V366	14.2178	3.93	Yes	No	0	7	6
5	R:R:V366	R:R:W367	13.1154	3.68	No	Yes	0	6	6
6	R:R:M128	R:R:Y370	10.0678	10.78	Yes	Yes	0	8	7
7	L:L:?1	R:R:S242	100	3.22	Yes	No	0	0	6
8	R:R:S242	R:R:T160	99.1827	4.8	No	No	0	6	7
9	R:R:S203	R:R:T160	97.51	6.4	No	No	0	8	7
10	R:R:A161	R:R:S203	96.6546	3.42	No	No	0	8	8
11	R:R:A161	R:R:W200	95.7866	3.89	No	Yes	0	8	9
12	R:R:H165	R:R:W200	91.3134	5.29	Yes	Yes	4	8	9
13	R:R:H165	R:R:L116	60.8946	7.71	Yes	No	0	8	9
14	R:R:D120	R:R:L116	59.7352	5.43	Yes	No	0	9	9
15	R:R:D120	R:R:N92	55.7689	6.73	Yes	No	0	9	9
16	R:R:M121	R:R:N92	15.6751	5.61	Yes	No	0	7	9
17	R:R:N92	R:R:P377	41.7031	6.52	No	No	0	9	9
18	R:R:P377	R:R:V95	40.2268	3.53	No	Yes	0	9	9
19	R:R:F391	R:R:V95	15.447	3.93	Yes	Yes	0	6	9
20	R:R:T381	R:R:V95	23.3162	3.17	No	Yes	0	7	9
21	R:R:T381	R:R:Y387	18.596	8.74	No	Yes	0	7	8
22	R:R:L105	R:R:Y387	10.2579	17.58	No	Yes	3	8	8
23	R:R:F112	R:R:H165	37.0589	9.05	Yes	Yes	0	8	8
24	R:R:F112	R:R:I169	15.8969	5.02	Yes	No	0	8	9
25	R:R:F112	R:R:K195	20.0215	16.13	Yes	No	0	8	6
26	R:R:D155	R:R:V127	24.2856	7.3	No	No	0	8	8
27	L:L:?1	R:R:V156	15.8715	11.17	Yes	No	0	0	6
28	R:R:S207	R:R:V156	12.6972	4.85	No	No	0	7	6
29	R:R:V127	R:R:W151	16.2136	9.81	No	Yes	0	8	5
30	R:R:W141	R:R:W151	14.4333	7.5	Yes	Yes	1	7	5
31	L:L:?1	R:R:L229	40.4422	4.45	Yes	No	0	0	4
32	R:R:I152	R:R:L229	28.4293	5.71	No	No	0	5	4
33	R:R:C227	R:R:I152	29.9119	3.27	Yes	No	0	9	5
34	R:R:C227	R:R:W141	14.3129	14.37	Yes	Yes	1	9	7
35	R:R:F222	R:R:W141	11.7341	4.01	Yes	Yes	0	2	7
36	R:R:C148	R:R:C227	15.4153	7.28	No	Yes	0	9	9
37	L:L:?1	R:R:F340	97.2502	10.43	Yes	Yes	2	0	7
38	R:R:F340	R:R:W336	62.4026	6.01	Yes	Yes	2	7	8
39	R:R:I163	R:R:W336	19.0078	5.87	No	Yes	0	8	8
40	R:R:I163	R:R:P246	17.6076	3.39	No	Yes	0	8	9
41	R:R:I169	R:R:R173	14.2622	5.01	No	No	0	9	9
42	R:R:R173	R:R:Y380	13.2104	7.2	No	Yes	0	9	9
43	R:R:F243	R:R:F340	47.6652	25.72	Yes	Yes	2	8	7
44	R:R:F243	R:R:F332	38.9786	3.22	Yes	Yes	2	8	9
45	R:R:F332	R:R:M250	78.838	11.2	Yes	No	0	9	8
46	R:R:F332	R:R:W336	42.0833	7.02	Yes	Yes	2	9	8
47	R:R:M250	R:R:S170	76.8802	6.13	No	No	0	8	9
48	R:R:S170	R:R:T253	74.5676	6.4	No	No	0	9	5
49	R:R:D172	R:R:K195	18.3489	6.91	No	No	0	9	6
50	R:R:D172	R:R:H183	10.1755	5.04	No	Yes	0	9	7
51	R:R:T253	R:R:Y174	72.2423	2.5	No	Yes	0	5	8
52	R:R:Q178	R:R:Y174	21.181	11.27	No	Yes	0	6	8
53	R:R:T257	R:R:Y174	43.3504	6.24	No	Yes	0	9	8
54	R:R:I177	R:R:T257	40.8604	4.56	No	No	0	9	9
55	R:R:I177	R:R:L261	38.3577	5.71	No	Yes	0	9	8
56	R:R:N179	R:R:Q178	15.9602	9.24	No	No	0	6	6
57	R:R:H182	R:R:N179	10.6887	1.28	No	No	0	5	6
58	R:R:F234	R:R:L229	13.863	3.65	No	No	0	7	4
59	R:R:F234	R:R:P209	14.5093	7.22	No	No	0	7	7
60	R:R:F213	R:R:P209	11.1322	2.89	No	No	0	4	7
61	R:R:C322	R:R:L261	26.3511	4.76	No	Yes	0	7	8
62	R:R:C322	R:R:I258	23.7724	3.27	No	No	0	7	5
63	R:R:I258	R:R:Y254	18.577	10.88	No	Yes	0	5	9
64	R:R:V379	R:R:Y380	12.2347	2.52	No	Yes	0	8	9
65	R:R:S372	R:R:W336	10.5937	4.94	No	Yes	0	9	8
66	R:R:F339	R:R:L362	17.3921	2.44	Yes	No	0	7	3
67	R:R:F339	R:R:F340	13.3435	10.72	Yes	Yes	2	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	8.72	2	Yes	No	0	8	0	1
L:L:?1	R:R:V156	11.17	2	Yes	No	0	6	0	1
L:L:?1	R:R:S159	16.08	2	Yes	No	0	7	0	1
L:L:?1	R:R:L229	4.45	2	Yes	No	0	4	0	1
L:L:?1	R:R:S242	3.22	2	Yes	No	0	6	0	1
L:L:?1	R:R:F339	16.96	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	10.43	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:N343	7.35	2	Yes	No	0	7	0	1
R:R:D155	R:R:V127	7.3	0	No	No	8	8	1	2
R:R:I152	R:R:I210	4.42	0	No	Yes	5	6	2	2
R:R:I152	R:R:L229	5.71	0	No	No	5	4	2	1
R:R:D155	R:R:Y370	6.9	0	No	Yes	8	7	1	2
R:R:S207	R:R:V156	4.85	0	No	No	7	6	2	1
R:R:I210	R:R:V156	4.61	0	Yes	No	6	6	2	1
R:R:S242	R:R:T160	4.8	0	No	No	6	7	1	2
R:R:F234	R:R:I210	6.28	0	No	Yes	7	6	2	2
R:R:F234	R:R:L229	3.65	0	No	No	7	4	2	1
R:R:N343	R:R:V235	4.43	0	No	No	7	6	1	2
R:R:F243	R:R:W336	4.01	2	Yes	Yes	8	8	2	2
R:R:F243	R:R:F340	25.72	2	Yes	Yes	8	7	2	1
R:R:F340	R:R:W336	6.01	2	Yes	Yes	7	8	1	2
R:R:F339	R:R:F340	10.72	2	Yes	Yes	7	7	1	1
R:R:F339	R:R:V366	3.93	2	Yes	No	7	6	1	2
R:R:F339	R:R:L362	2.44	2	Yes	No	7	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LL9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	242
Number of Links	252
Number of Hubs	31
Number of Links mediated by Hubs	122
Number of Communities	4
Number of Nodes involved in Communities	22
Number of Links involved in Communities	28

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	34815
Length Of Smallest Path	3
Average Path Length	14.5252
Length of Longest Path	34
Minimum Path Strength	1.455
Average Path Strength	6.38722
Maximum Path Strength	18.22
Minimum Path Correlation	0.7
Average Path Correlation	0.914494
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	45.65
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.4154
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D1 dopamine receptor binding • dopamine receptor binding • cyclase regulator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • hormone-mediated signaling pathway • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • system process • sensory perception • nervous system process • sensory perception of itch • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of chemical stimulus • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • homotypic cell-cell adhesion • platelet aggregation • cell adhesion • cell-cell adhesion • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • nuclear membrane • nucleus • endomembrane system • organelle envelope • nuclear envelope • Golgi apparatus • postsynapse • postsynaptic cytosol • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • ciliary basal body • protein tyrosine kinase activator activity • kinase activator activity • protein kinase activator activity • protein kinase regulator activity • kinase regulator activity • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • Gq/11-coupled serotonin receptor activity • identical protein binding • serotonin binding • amine binding • virus receptor activity • exogenous protein binding • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • response to xenobiotic stimulus • trans-synaptic signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • positive regulation of defense response • regulation of tube diameter • regulation of tube size • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • protein localization to cytoskeleton • protein localization to organelle • glycerophospholipid metabolic process • positive regulation of phosphate metabolic process • phospholipid metabolic process • phosphate-containing compound metabolic process • positive regulation of phosphatidylinositol biosynthetic process • phosphorus metabolic process • regulation of phosphatidylinositol biosynthetic process • phosphatidylinositol metabolic process • positive regulation of phosphorus metabolic process • glycerophospholipid biosynthetic process • positive regulation of phospholipid biosynthetic process • regulation of phospholipid metabolic process • phospholipid biosynthetic process • regulation of phospholipid biosynthetic process • phosphatidylinositol biosynthetic process • positive regulation of phospholipid metabolic process • glycerolipid biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • regulation of phosphorus metabolic process • glycerolipid metabolic process • neuron apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • positive regulation of neuron apoptotic process • programmed cell death • regulation of neuron apoptotic process • behavior • learning or memory • memory • inorganic ion homeostasis • intracellular calcium ion homeostasis • calcium ion homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cell-cell adhesion • regulation of cell-cell adhesion • regulation of homotypic cell-cell adhesion • positive regulation of cell adhesion • regulation of cell adhesion • regulation of platelet aggregation • positive regulation of homotypic cell-cell adhesion • positive regulation of platelet aggregation • ribonucleotide catabolic process • pyridine nucleotide catabolic process • aerobic respiration • oxoacid metabolic process • carbohydrate catabolic process • carbohydrate derivative metabolic process • organophosphate catabolic process • nucleoside phosphate catabolic process • organic acid metabolic process • nucleobase-containing compound metabolic process • glycolytic process • pyridine-containing compound metabolic process • purine ribonucleotide catabolic process • nucleoside phosphate metabolic process • nicotinamide nucleotide metabolic process • pyruvate metabolic process • purine nucleoside diphosphate metabolic process • purine-containing compound catabolic process • nucleotide metabolic process • nucleobase-containing compound catabolic process • nucleoside diphosphate metabolic process • purine nucleoside diphosphate catabolic process • nucleoside diphosphate catabolic process • nucleoside triphosphate metabolic process • monocarboxylic acid metabolic process • purine ribonucleotide metabolic process • pyridine-containing compound catabolic process • ribose phosphate metabolic process • cellular respiration • catabolic process • ATP metabolic process • energy derivation by oxidation of organic compounds • purine nucleotide metabolic process • ribonucleotide metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • ribonucleoside diphosphate metabolic process • ribonucleoside diphosphate catabolic process • nucleotide catabolic process • purine nucleoside triphosphate metabolic process • purine nucleotide catabolic process • carbohydrate metabolic process • carbohydrate derivative catabolic process • ADP catabolic process • carboxylic acid metabolic process • generation of precursor metabolites and energy • purine-containing compound metabolic process • ADP metabolic process • purine ribonucleoside diphosphate metabolic process • purine ribonucleoside diphosphate catabolic process • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of synaptic transmission, glutamatergic • smooth muscle contraction • urinary bladder smooth muscle contraction • urinary tract smooth muscle contraction • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of potassium ion transport • regulation of potassium ion transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of cytosolic calcium ion concentration • regulation of heat generation • positive regulation of heat generation • heat generation • regulation of generation of precursor metabolites and energy • regulation of ATP metabolic process • regulation of purine nucleotide catabolic process • positive regulation of nucleotide catabolic process • regulation of nucleotide metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of carbohydrate catabolic process • regulation of purine nucleotide metabolic process • positive regulation of ATP metabolic process • regulation of nucleotide catabolic process • positive regulation of carbohydrate metabolic process • positive regulation of nucleotide metabolic process • positive regulation of purine nucleotide catabolic process • regulation of carbohydrate metabolic process • positive regulation of glycolytic process • regulation of catabolic process • regulation of glycolytic process • positive regulation of purine nucleotide metabolic process • positive regulation of catabolic process • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • detection of mechanical stimulus involved in sensory perception of pain • response to mechanical stimulus • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • positive regulation of signal transduction • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • learning • nonassociative learning • sensitization • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • dopamine transport • catecholamine transport • dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • positive regulation of cell population proliferation • regulation of cell population proliferation • calcium ion transmembrane import into cytosol • monoatomic ion transmembrane transport • calcium ion transport • monoatomic cation transmembrane transport • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • vascular associated smooth muscle contraction • artery smooth muscle contraction • tonic smooth muscle contraction • regulation of DNA biosynthetic process • positive regulation of macromolecule biosynthetic process • nucleic acid biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of DNA biosynthetic process • regulation of macromolecule metabolic process • DNA metabolic process • nucleobase-containing compound biosynthetic process • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of DNA metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • DNA biosynthetic process • regulation of DNA metabolic process • regulation of immune effector process • cytokine production • regulation of cytokine production • positive regulation of immune effector process • cytokine production involved in immune response • positive regulation of immune system process • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • gene expression • regulation of gene expression • positive regulation of gene expression • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • positive regulation of cytokine production • postsynaptic membrane • plasma membrane region • synaptic membrane • G protein-coupled serotonin receptor complex • receptor complex • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • glutamatergic synapse • dendritic shaft • cell body • neuronal cell body • axon • membrane microdomain • membrane raft • plasma membrane raft • caveola • cell body fiber • cytoplasmic vesicle • intracellular vesicle • polymeric cytoskeletal fiber • neurofilament • intermediate filament cytoskeleton • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9LL9_nogp_Chain_R A L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.54	2025-04-02	10.1038/s41467-025-57956-7
	9AS8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.54	2025-04-02	10.1038/s41467-025-57956-7
	9LL9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.76	2026-01-14	To be published
	9LL9 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.76	2026-01-14	To be published
	9LLA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.27	2026-01-14	To be published
	9LLA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-		3.27	2026-01-14	To be published
	9LLB	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.98	2026-01-14	To be published
	9LLB (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-		2.98	2026-01-14	To be published
	9LL7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	Gi1/β1/γ2	2.84	2026-01-14	To be published
	9LL7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.84	2026-01-14	To be published
	9LL8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	Gi1/β1/γ2	2.62	2026-01-14	To be published
	9LL8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.62	2026-01-14	To be published

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Download 9LL9_nogp.zip

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