psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	15.17	Yes	Yes	1	0	8
2	L:L:?1	R:R:V156	10.59	Yes	No	0	0	6
3	L:L:?1	R:R:S159	9.15	Yes	No	1	0	7
4	L:L:?1	R:R:T160	2.99	Yes	Yes	1	0	7
5	L:L:?1	R:R:L229	4.22	Yes	No	0	0	4
6	L:L:?1	R:R:F234	4.95	Yes	Yes	0	0	7
7	L:L:?1	R:R:G238	3.48	Yes	No	0	0	6
8	L:L:?1	R:R:S239	3.05	Yes	No	1	0	6
9	L:L:?1	R:R:S242	9.15	Yes	No	1	0	6
10	L:L:?1	R:R:F339	14.85	Yes	Yes	1	0	7
11	L:L:?1	R:R:F340	9.9	Yes	Yes	1	0	7
12	R:R:M132	R:R:T81	7.53	No	No	0	6	6
13	R:R:T81	R:R:W367	13.34	No	Yes	0	6	6
14	R:R:L87	R:R:V83	2.98	No	No	0	4	4
15	R:R:V84	R:R:W367	3.68	No	Yes	0	7	6
16	R:R:I85	R:R:M128	4.37	No	Yes	0	6	8
17	R:R:I86	R:R:L87	2.85	No	No	0	4	4
18	R:R:N92	R:R:T88	2.92	Yes	No	0	9	7
19	R:R:M128	R:R:T88	4.52	Yes	No	0	8	7
20	R:R:A374	R:R:T88	3.36	No	No	0	6	7
21	R:R:I89	R:R:I93	2.94	No	No	0	5	3
22	R:R:D120	R:R:N92	6.73	Yes	Yes	0	9	9
23	R:R:M121	R:R:N92	4.21	No	Yes	0	7	9
24	R:R:N92	R:R:P377	6.52	Yes	No	0	9	9
25	R:R:I93	R:R:M97	2.92	No	No	0	3	4
26	R:R:F391	R:R:L94	3.65	No	No	0	6	6
27	R:R:A117	R:R:V95	3.39	No	No	0	9	9
28	R:R:T381	R:R:V95	4.76	No	No	0	7	9
29	R:R:A117	R:R:I96	3.25	No	No	0	9	6
30	R:R:A98	R:R:F391	4.16	No	No	0	7	6
31	R:R:V99	R:R:Y387	3.79	No	Yes	0	7	8
32	R:R:E102	R:R:R393	4.65	No	No	0	6	4
33	R:R:L105	R:R:N110	8.24	No	No	5	8	9
34	R:R:L105	R:R:T386	2.95	No	No	0	8	6
35	R:R:L105	R:R:Y387	5.86	No	Yes	5	8	8
36	R:R:Q106	R:R:Y111	9.02	No	No	0	7	4
37	R:R:N107	R:R:N110	6.81	No	No	0	7	9
38	R:R:N110	R:R:Y387	8.14	No	Yes	5	9	8
39	R:R:F112	R:R:H165	10.18	Yes	Yes	2	8	8
40	R:R:F112	R:R:I169	5.02	Yes	No	0	8	9
41	R:R:F112	R:R:K195	13.65	Yes	No	0	8	6
42	R:R:F112	R:R:V199	5.24	Yes	No	2	8	6
43	R:R:H165	R:R:S115	8.37	Yes	No	2	8	9
44	R:R:I196	R:R:S115	6.19	No	No	0	8	9
45	R:R:S115	R:R:W200	4.94	No	Yes	2	9	9
46	R:R:D120	R:R:L116	5.43	Yes	No	0	9	9
47	R:R:H165	R:R:L116	7.71	Yes	No	0	8	9
48	R:R:D120	R:R:S162	4.42	Yes	No	0	9	9
49	R:R:D120	R:R:S373	7.36	Yes	No	0	9	9
50	R:R:D120	R:R:N376	6.73	Yes	No	0	9	9
51	R:R:F158	R:R:L122	9.74	Yes	No	0	7	7
52	R:R:L123	R:R:V127	4.47	Yes	No	0	7	8
53	R:R:L123	R:R:M128	2.83	Yes	Yes	0	7	8
54	R:R:F158	R:R:L123	6.09	Yes	Yes	0	7	7
55	R:R:L123	R:R:S373	3	Yes	No	0	7	9
56	R:R:G124	R:R:M128	6.99	No	Yes	0	6	8
57	R:R:F125	R:R:L126	4.87	No	No	0	4	5
58	R:R:V127	R:R:W151	8.58	No	Yes	0	8	5
59	R:R:D155	R:R:V127	5.84	Yes	No	0	8	8
60	R:R:M128	R:R:Y370	10.78	Yes	Yes	0	8	7
61	R:R:V130	R:R:W151	11.03	No	Yes	0	4	5
62	R:R:S131	R:R:W151	4.94	No	Yes	0	7	5
63	R:R:S131	R:R:W367	6.18	No	Yes	0	7	6
64	R:R:L133	R:R:Y137	4.69	No	No	6	4	4
65	R:R:L133	R:R:P142	3.28	No	No	6	4	3
66	R:R:I135	R:R:Y139	3.63	No	Yes	0	5	3
67	R:R:I135	R:R:W367	5.87	No	Yes	0	5	6
68	R:R:P142	R:R:Y137	16.69	No	No	6	3	4
69	R:R:N363	R:R:Y139	16.28	No	Yes	0	4	3
70	R:R:P142	R:R:W141	5.4	No	Yes	0	3	7
71	R:R:L143	R:R:W141	6.83	No	Yes	0	5	7
72	R:R:W141	R:R:W151	7.5	Yes	Yes	0	7	5
73	R:R:C227	R:R:W141	13.06	No	Yes	0	9	7
74	R:R:L143	R:R:P144	4.93	No	No	0	5	7
75	R:R:K146	R:R:S145	3.06	No	No	0	1	3
76	R:R:F222	R:R:S145	3.96	Yes	No	0	2	3
77	R:R:K146	R:R:L215	2.82	No	No	0	1	5
78	R:R:C148	R:R:V221	3.42	No	No	3	9	3
79	R:R:C148	R:R:F222	6.98	No	Yes	3	9	2
80	R:R:C148	R:R:C227	7.28	No	No	3	9	9
81	R:R:L154	R:R:V150	2.98	Yes	No	0	5	4
82	R:R:I152	R:R:I210	2.94	No	Yes	0	5	6
83	R:R:I152	R:R:V221	3.07	No	No	0	5	3
84	R:R:I152	R:R:L229	4.28	No	No	0	5	4
85	R:R:L154	R:R:Y153	3.52	Yes	Yes	0	5	6
86	R:R:L157	R:R:Y153	3.52	Yes	Yes	7	6	6
87	R:R:S207	R:R:Y153	3.82	No	Yes	7	7	6
88	R:R:P211	R:R:Y153	9.74	No	Yes	0	5	6
89	R:R:F158	R:R:L154	3.65	Yes	Yes	0	7	5
90	R:R:D155	R:R:S159	2.94	Yes	No	1	8	7
91	R:R:D155	R:R:Y370	5.75	Yes	Yes	0	8	7
92	R:R:S207	R:R:V156	4.85	No	No	0	7	6
93	R:R:I210	R:R:V156	4.61	Yes	No	0	6	6
94	R:R:F158	R:R:L157	4.87	Yes	Yes	0	7	6
95	R:R:L157	R:R:S207	6.01	Yes	No	7	6	7
96	R:R:F158	R:R:W200	4.01	Yes	Yes	0	7	9
97	R:R:M164	R:R:T160	3.01	No	Yes	0	6	7
98	R:R:S203	R:R:T160	3.2	No	Yes	0	8	7
99	R:R:S242	R:R:T160	7.99	No	Yes	1	6	7
100	R:R:A161	R:R:W200	3.89	No	Yes	0	8	9
101	R:R:A161	R:R:S203	3.42	No	No	0	8	8
102	R:R:I163	R:R:P246	3.39	No	Yes	0	8	9
103	R:R:F332	R:R:I163	3.77	Yes	No	0	9	8
104	R:R:M164	R:R:V199	3.04	No	No	0	6	6
105	R:R:M164	R:R:P246	3.35	No	Yes	0	6	9
106	R:R:H165	R:R:V199	8.3	Yes	No	2	8	6
107	R:R:H165	R:R:W200	4.23	Yes	Yes	2	8	9
108	R:R:L166	R:R:N376	6.87	No	No	0	8	9
109	R:R:L166	R:R:Y380	8.21	No	No	0	8	9
110	R:R:C167	R:R:P246	3.77	No	Yes	0	6	9
111	R:R:C167	R:R:I249	4.91	No	No	0	6	6
112	R:R:I169	R:R:R173	6.26	No	No	0	9	9
113	R:R:S170	R:R:T253	3.2	No	No	0	9	5
114	R:R:I249	R:R:L171	4.28	No	No	0	6	6
115	R:R:L171	R:R:T253	5.9	No	No	0	6	5
116	R:R:D172	R:R:H183	7.56	No	Yes	4	9	7
117	R:R:D172	R:R:K191	6.91	No	Yes	4	9	6
118	R:R:D172	R:R:K195	6.91	No	No	0	9	6
119	R:R:Q178	R:R:Y174	7.89	No	No	0	6	8
120	R:R:T257	R:R:Y174	6.24	No	No	0	9	8
121	R:R:H183	R:R:V175	4.15	Yes	No	0	7	5
122	R:R:A176	R:R:H183	5.85	No	Yes	0	8	7
123	R:R:I177	R:R:T257	4.56	No	No	0	9	9
124	R:R:I177	R:R:L261	4.28	No	No	0	9	8
125	R:R:Q178	R:R:S260	7.22	No	No	0	6	6
126	R:R:H183	R:R:N187	3.83	Yes	No	4	7	6
127	R:R:H183	R:R:K191	3.93	Yes	Yes	4	7	6
128	R:R:F186	R:R:R185	7.48	No	No	0	4	4
129	R:R:K191	R:R:N187	5.6	Yes	No	4	6	6
130	R:R:S188	R:R:T190	3.2	No	No	0	7	5
131	R:R:F193	R:R:R189	8.55	No	No	0	4	4
132	R:R:I202	R:R:I206	2.94	No	No	0	5	6
133	R:R:M208	R:R:P209	3.35	No	No	0	4	7
134	R:R:F234	R:R:P209	7.22	Yes	No	0	7	7
135	R:R:I210	R:R:P211	3.39	Yes	No	0	6	5
136	R:R:F234	R:R:I210	5.02	Yes	Yes	0	7	6
137	R:R:F213	R:R:V212	3.93	No	No	0	4	5
138	R:R:F213	R:R:Q216	10.54	No	No	0	4	6
139	R:R:D217	R:R:Q216	7.83	No	No	0	4	6
140	R:R:D217	R:R:K220	20.74	No	No	0	4	3
141	R:R:F222	R:R:V221	3.93	Yes	No	3	2	3
142	R:R:C227	R:R:F222	2.79	No	Yes	3	9	2
143	R:R:K223	R:R:L228	5.64	No	No	0	3	4
144	R:R:E224	R:R:G225	3.27	No	No	0	2	3
145	R:R:D232	R:R:V347	7.3	No	No	0	4	5
146	R:R:N343	R:R:V235	4.43	No	No	0	7	6
147	R:R:V235	R:R:V347	3.21	No	No	0	6	5
148	R:R:I344	R:R:L236	2.85	No	No	0	5	6
149	R:R:L236	R:R:V347	4.47	No	No	0	6	5
150	R:R:F340	R:R:S239	5.28	Yes	No	1	7	6
151	R:R:I344	R:R:S239	3.1	No	No	0	5	6
152	R:R:F240	R:R:I245	7.54	No	No	0	4	5
153	R:R:F243	R:R:F244	6.43	Yes	No	0	8	5
154	R:R:F243	R:R:F332	7.5	Yes	Yes	1	8	9
155	R:R:F243	R:R:W336	4.01	Yes	Yes	1	8	8
156	R:R:C337	R:R:F243	2.79	No	Yes	0	6	8
157	R:R:F243	R:R:F340	22.51	Yes	Yes	1	8	7
158	R:R:I245	R:R:P246	3.39	No	Yes	0	5	9
159	R:R:F332	R:R:M250	13.68	Yes	No	0	9	8
160	R:R:F329	R:R:V251	3.93	Yes	No	0	8	5
161	R:R:F255	R:R:Y254	4.13	No	Yes	0	1	9
162	R:R:I258	R:R:Y254	10.88	Yes	Yes	0	5	9
163	R:R:G326	R:R:Y254	4.35	No	Yes	0	6	9
164	R:R:F329	R:R:Y254	13.41	Yes	Yes	0	8	9
165	R:R:L325	R:R:T257	2.95	No	No	0	8	9
166	R:R:C322	R:R:I258	4.91	No	Yes	0	7	5
167	R:R:I258	R:R:L325	2.85	Yes	No	0	5	8
168	R:R:E318	R:R:L261	5.3	No	No	0	8	8
169	R:R:I315	R:R:N317	7.08	No	No	0	5	6
170	R:R:E318	R:R:I315	9.56	No	No	0	8	5
171	R:R:K320	R:R:K323	2.87	No	No	0	8	7
172	R:R:F383	R:R:V324	9.18	No	No	0	7	8
173	R:R:V328	R:R:Y380	6.31	No	No	0	8	9
174	R:R:F329	R:R:F330	10.72	Yes	No	0	8	5
175	R:R:F329	R:R:V333	5.24	Yes	No	0	8	6
176	R:R:L331	R:R:V379	2.98	No	No	0	6	8
177	R:R:C337	R:R:V333	3.42	No	No	0	6	6
178	R:R:M335	R:R:S372	7.67	No	No	0	8	9
179	R:R:F339	R:R:W336	5.01	Yes	Yes	1	7	8
180	R:R:F340	R:R:W336	4.01	Yes	Yes	1	7	8
181	R:R:G369	R:R:W336	8.44	No	Yes	0	7	8
182	R:R:F365	R:R:P338	8.67	Yes	No	0	5	9
183	R:R:F339	R:R:F340	12.86	Yes	Yes	1	7	7
184	R:R:F339	R:R:N343	3.62	Yes	No	0	7	7
185	R:R:I358	R:R:T342	3.04	Yes	No	0	4	5
186	R:R:L362	R:R:T342	4.42	No	No	0	3	5
187	R:R:F365	R:R:T342	9.08	Yes	No	0	5	5
188	R:R:I344	R:R:I348	2.94	No	No	0	5	4
189	R:R:I358	R:R:M345	2.92	Yes	No	0	4	4
190	R:R:A346	R:R:I358	3.25	No	Yes	0	4	4
191	R:R:N354	R:R:V357	7.39	No	No	0	1	5
192	R:R:F365	R:R:L361	7.31	Yes	No	0	5	4
193	R:R:V366	R:R:Y370	6.31	No	Yes	0	6	7
194	R:R:W367	R:R:Y370	7.72	Yes	Yes	0	6	7
195	R:R:L378	R:R:L382	4.15	No	No	0	6	5
196	R:R:V379	R:R:Y380	3.79	No	No	0	8	9
197	R:R:T381	R:R:Y387	13.73	No	Yes	0	7	8
198	R:R:N384	R:R:T386	2.92	No	No	0	9	6
199	R:R:N384	R:R:Y387	5.81	No	Yes	0	9	8
200	R:R:K385	R:R:R388	9.9	No	No	0	5	9
201	R:R:A168	R:R:F112	2.77	No	Yes	0	7	8
202	R:R:L362	R:R:N343	2.75	No	No	0	3	7
203	R:R:E355	R:R:I358	2.73	No	Yes	0	3	4
204	R:R:K103	R:R:Q106	2.71	No	No	0	6	7
205	R:R:A98	R:R:Y387	2.67	No	Yes	0	7	8
206	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
207	R:R:F365	R:R:I368	2.51	Yes	No	0	5	7
208	R:R:F243	R:R:L247	2.44	Yes	No	1	8	6
209	R:R:F332	R:R:L247	2.44	Yes	No	1	9	6
210	R:R:F391	R:R:L382	2.44	No	No	0	6	5
211	R:R:T134	R:R:W141	2.43	No	Yes	0	5	7
212	R:R:D231	R:R:F234	2.39	No	Yes	0	5	7
213	R:R:L113	R:R:Y387	2.34	No	Yes	0	8	8
214	R:R:L136	R:R:Y137	2.34	No	No	0	5	4
215	R:R:L256	R:R:Y174	2.34	No	No	0	5	8
216	R:R:H182	R:R:R185	2.26	No	No	0	5	4
217	R:R:A90	R:R:G91	1.95	No	No	0	4	8
218	R:R:G225	R:R:S226	1.86	No	No	0	3	4
219	R:R:G369	R:R:S372	1.86	No	No	0	7	9
220	R:R:A390	R:R:A98	1.79	No	No	0	7	7
221	R:R:A108	R:R:A192	1.79	No	No	0	5	7
222	R:R:P377	R:R:V95	1.77	No	No	0	9	9
223	R:R:P211	R:R:V212	1.77	No	No	0	5	5
224	R:R:G359	R:R:I358	1.76	No	Yes	0	2	4
225	R:R:G91	R:R:L94	1.71	No	No	0	8	6
226	R:R:M128	R:R:P129	1.68	Yes	No	0	8	8
227	R:R:L147	R:R:P144	1.64	No	No	0	5	7
228	R:R:C337	R:R:I341	1.64	No	No	0	6	6
229	R:R:C349	R:R:I348	1.64	No	No	0	3	4
230	R:R:N179	R:R:P180	1.63	No	No	0	6	8
231	R:R:A82	R:R:M132	1.61	No	No	0	3	6
232	R:R:V375	R:R:V379	1.6	No	No	0	6	8
233	R:R:S389	R:R:T386	1.6	No	No	0	4	6
234	R:R:A149	R:R:L215	1.58	No	No	0	6	5
235	R:R:A321	R:R:L261	1.58	No	No	0	8	8
236	R:R:I96	R:R:S100	1.55	No	No	0	6	1
237	R:R:I206	R:R:V241	1.54	No	No	0	6	4
238	R:R:I237	R:R:V241	1.54	No	No	0	4	4
239	R:R:I368	R:R:V364	1.54	No	No	0	7	4
240	R:R:K191	R:R:S188	1.53	Yes	No	0	6	7
241	R:R:M114	R:R:V99	1.52	No	No	0	5	7
242	R:R:I206	R:R:T160	1.52	No	Yes	0	6	7
243	R:R:I197	R:R:T201	1.52	No	No	0	2	4
244	R:R:I252	R:R:T248	1.52	No	No	0	5	3
245	R:R:A390	R:R:E102	1.51	No	No	0	7	6
246	R:R:L371	R:R:V84	1.49	No	No	0	4	7
247	R:R:L157	R:R:V204	1.49	Yes	No	0	6	4
248	R:R:N317	R:R:S316	1.49	No	No	0	6	6
249	R:R:L361	R:R:V357	1.49	No	No	0	4	5
250	R:R:L371	R:R:V375	1.49	No	No	0	4	6
251	R:R:I85	R:R:I89	1.47	No	No	0	6	5
252	R:R:I118	R:R:I96	1.47	No	No	0	6	6
253	R:R:L194	R:R:T190	1.47	No	No	0	3	5
254	R:R:D218	R:R:S219	1.47	No	No	0	3	3
255	R:R:N107	R:R:T109	1.46	No	No	0	7	8
256	R:R:G138	R:R:Y139	1.45	No	Yes	0	5	3
257	R:R:I252	R:R:L256	1.43	No	No	0	5	5
258	R:R:I327	R:R:L331	1.43	No	No	0	6	6
259	R:R:L101	R:R:M97	1.41	No	No	0	5	4
260	R:R:L126	R:R:L154	1.38	No	Yes	0	5	5
261	R:R:I258	R:R:Q262	1.37	Yes	No	0	5	6
262	R:R:K320	R:R:Q319	1.36	No	No	0	8	5
263	R:R:D356	R:R:N354	1.35	No	No	0	2	1
264	R:R:N179	R:R:Q178	1.32	No	No	0	6	6
265	R:R:R189	R:R:T190	1.29	No	No	0	4	5
266	R:R:H182	R:R:N179	1.28	No	No	0	5	6
267	R:R:S226	R:R:Y139	1.27	No	Yes	0	4	3
268	R:R:I181	R:R:R185	1.25	No	No	0	7	4
269	R:R:L382	R:R:R388	1.21	No	No	0	5	9
270	R:R:M114	R:R:Y111	1.2	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.95455	11	1	0
2	R:R:N92	5.095	4	0	9
3	R:R:F112	7.372	5	2	8
4	R:R:D120	6.134	5	0	9
5	R:R:L123	4.0975	4	0	7
6	R:R:M128	5.195	6	0	8
7	R:R:Y139	5.6575	4	0	3
8	R:R:W141	7.044	5	0	7
9	R:R:W151	8.0125	4	0	5
10	R:R:Y153	5.15	4	7	6
11	R:R:L154	2.8825	4	0	5
12	R:R:D155	7.425	4	1	8
13	R:R:L157	3.9725	4	7	6
14	R:R:F158	5.672	5	0	7
15	R:R:T160	3.742	5	1	7
16	R:R:H165	7.758	5	2	8
17	R:R:H183	5.064	5	4	7
18	R:R:K191	4.4925	4	4	6
19	R:R:W200	3.932	5	2	9
20	R:R:I210	3.99	4	0	6
21	R:R:F222	4.415	4	3	2
22	R:R:F234	4.895	4	0	7
23	R:R:F243	7.61333	6	1	8
24	R:R:P246	3.475	4	0	9
25	R:R:Y254	8.1925	4	0	9
26	R:R:I258	5.0025	4	0	5
27	R:R:F329	8.325	4	0	8
28	R:R:F332	6.8475	4	1	9
29	R:R:W336	5.3675	4	1	8
30	R:R:F339	9.085	4	1	7
31	R:R:F340	10.912	5	1	7
32	R:R:I358	2.74	5	0	4
33	R:R:F365	6.8925	4	0	5
34	R:R:W367	7.358	5	0	6
35	R:R:Y370	7.64	4	0	7
36	R:R:Y387	6.04857	7	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	100	15.17	Yes	Yes	1	0	8
2	R:R:D155	R:R:Y370	76.3612	5.75	Yes	Yes	0	8	7
3	R:R:W367	R:R:Y370	39.7204	7.72	Yes	Yes	0	6	7
4	R:R:V84	R:R:W367	14.6731	3.68	No	Yes	0	7	6
5	R:R:M128	R:R:Y370	61.7511	10.78	Yes	Yes	0	8	7
6	R:R:I85	R:R:M128	13.1806	4.37	No	Yes	0	6	8
7	R:R:M128	R:R:T88	66.544	4.52	Yes	No	0	8	7
8	R:R:N92	R:R:T88	64.3998	2.92	Yes	No	0	9	7
9	R:R:I85	R:R:I89	10.5844	1.47	No	No	0	6	5
10	R:R:D155	R:R:V127	25.6464	5.84	Yes	No	0	8	8
11	R:R:L123	R:R:V127	33.9815	4.47	Yes	No	0	7	8
12	R:R:L123	R:R:S373	29.094	3	Yes	No	0	7	9
13	R:R:D120	R:R:S373	28.1059	7.36	Yes	No	0	9	9
14	R:R:N92	R:R:P377	94.9233	6.52	Yes	No	0	9	9
15	R:R:P377	R:R:V95	92.4637	1.77	No	No	0	9	9
16	R:R:T381	R:R:V95	80.0715	4.76	No	No	0	7	9
17	R:R:T381	R:R:Y387	77.8747	13.73	No	Yes	0	7	8
18	R:R:A98	R:R:Y387	35.4951	2.67	No	Yes	0	7	8
19	R:R:A98	R:R:F391	23.8806	4.16	No	No	0	7	6
20	R:R:A117	R:R:V95	12.2346	3.39	No	No	0	9	9
21	R:R:V99	R:R:Y387	15.2407	3.79	No	Yes	0	7	8
22	R:R:M114	R:R:V99	12.2661	1.52	No	No	0	5	7
23	L:L:?1	R:R:T160	50.9985	2.99	Yes	Yes	1	0	7
24	R:R:M164	R:R:T160	39.2264	3.01	No	Yes	0	6	7
25	R:R:M164	R:R:V199	45.0704	3.04	No	No	0	6	6
26	R:R:F112	R:R:V199	27.7381	5.24	Yes	No	2	8	6
27	R:R:H165	R:R:V199	16.5335	8.3	Yes	No	2	8	6
28	R:R:F112	R:R:K195	37.8074	13.65	Yes	No	0	8	6
29	R:R:H165	R:R:L116	23.3551	7.71	Yes	No	0	8	9
30	R:R:D120	R:R:N376	14.2842	6.73	Yes	No	0	9	9
31	R:R:F158	R:R:L123	38.869	6.09	Yes	Yes	0	7	7
32	L:L:?1	R:R:V156	21.6103	10.59	Yes	No	0	0	6
33	R:R:S207	R:R:V156	10.9733	4.85	No	No	0	7	6
34	R:R:F158	R:R:L157	16.8594	4.87	Yes	Yes	0	7	6
35	R:R:L154	R:R:Y153	14.4839	3.52	Yes	Yes	0	5	6
36	R:R:V127	R:R:W151	38.1017	8.58	No	Yes	0	8	5
37	R:R:W141	R:R:W151	35.4846	7.5	Yes	Yes	0	7	5
38	R:R:P142	R:R:W141	12.2241	5.4	No	Yes	0	3	7
39	R:R:I135	R:R:W367	18.8564	5.87	No	Yes	0	5	6
40	R:R:I135	R:R:Y139	16.502	3.63	No	Yes	0	5	3
41	R:R:C227	R:R:W141	13.9374	13.06	No	Yes	0	9	7
42	L:L:?1	R:R:L229	15.2933	4.22	Yes	No	0	0	4
43	R:R:I152	R:R:L229	13.601	4.28	No	No	0	5	4
44	R:R:I152	R:R:V221	15.2617	3.07	No	No	0	5	3
45	R:R:F222	R:R:S145	11.6565	3.96	Yes	No	0	2	3
46	R:R:I210	R:R:V156	10.3637	4.61	Yes	No	0	6	6
47	R:R:I210	R:R:P211	19.1928	3.39	Yes	No	0	6	5
48	L:L:?1	R:R:F234	18.1207	4.95	Yes	Yes	0	0	7
49	R:R:F234	R:R:I210	10.7736	5.02	Yes	Yes	0	7	6
50	R:R:M164	R:R:P246	28.4528	3.35	No	Yes	0	6	9
51	R:R:I163	R:R:P246	15.6296	3.39	No	Yes	0	8	9
52	L:L:?1	R:R:F340	76.235	9.9	Yes	Yes	1	0	7
53	R:R:F243	R:R:F340	78.5474	22.51	Yes	Yes	1	8	7
54	R:R:F243	R:R:F332	17.7738	7.5	Yes	Yes	1	8	9
55	R:R:F332	R:R:I163	15.535	3.77	Yes	No	0	9	8
56	R:R:L166	R:R:N376	11.5829	6.87	No	No	0	8	9
57	R:R:L371	R:R:V84	12.0034	1.49	No	No	0	4	7
58	R:R:C167	R:R:P246	12.6235	3.77	No	Yes	0	6	9
59	R:R:C167	R:R:I249	10.0799	4.91	No	No	0	6	6
60	R:R:D172	R:R:K195	35.0536	6.91	No	No	0	9	6
61	R:R:D172	R:R:H183	11.7091	7.56	No	Yes	4	9	7
62	R:R:D172	R:R:K191	20.7799	6.91	No	Yes	4	9	6
63	R:R:C337	R:R:F243	88.827	2.79	No	Yes	0	6	8
64	R:R:C337	R:R:V333	83.992	3.42	No	No	0	6	6
65	R:R:F329	R:R:V333	81.543	5.24	Yes	No	0	8	6
66	R:R:F329	R:R:Y254	74.3641	13.41	Yes	Yes	0	8	9
67	R:R:I258	R:R:Y254	67.0696	10.88	Yes	Yes	0	5	9
68	R:R:I258	R:R:L325	59.2075	2.85	Yes	No	0	5	8
69	R:R:L325	R:R:T257	56.9056	2.95	No	No	0	8	9
70	R:R:T257	R:R:Y174	35.5581	6.24	No	No	0	9	8
71	R:R:Q178	R:R:Y174	24.0383	7.89	No	No	0	6	8
72	R:R:I177	R:R:T257	20.433	4.56	No	No	0	9	9
73	R:R:I177	R:R:L261	17.4795	4.28	No	No	0	9	8
74	R:R:N179	R:R:Q178	18.1522	1.32	No	No	0	6	6
75	R:R:H182	R:R:N179	12.182	1.28	No	No	0	5	6
76	R:R:K191	R:R:S188	15.3878	1.53	Yes	No	0	6	7
77	R:R:S188	R:R:T190	12.3502	3.2	No	No	0	7	5
78	R:R:I206	R:R:T160	12.182	1.52	No	Yes	0	6	7
79	R:R:P211	R:R:V212	28.2636	1.77	No	No	0	5	5
80	R:R:F213	R:R:V212	22.6508	3.93	No	No	0	4	5
81	R:R:F213	R:R:Q216	17.017	10.54	No	No	0	4	6
82	R:R:D217	R:R:Q216	11.3622	7.83	No	No	0	4	6
83	L:L:?1	R:R:S239	13.6851	3.05	Yes	No	1	0	6
84	R:R:I344	R:R:S239	14.9149	3.1	No	No	0	5	6
85	L:L:?1	R:R:F339	45.2596	14.85	Yes	Yes	1	0	7
86	R:R:F339	R:R:N343	53.3004	3.62	Yes	No	0	7	7
87	R:R:F339	R:R:W336	16.1341	5.01	Yes	Yes	1	7	8
88	R:R:E318	R:R:L261	11.8352	5.3	No	No	0	8	8
89	R:R:G369	R:R:W336	13.1701	8.44	No	Yes	0	7	8
90	R:R:L362	R:R:N343	43.704	2.75	No	No	0	3	7
91	R:R:L362	R:R:T342	41.2865	4.42	No	No	0	3	5
92	R:R:F365	R:R:T342	24.0593	9.08	Yes	No	0	5	5
93	R:R:I358	R:R:T342	15.1776	3.04	Yes	No	0	4	5
94	R:R:F365	R:R:L361	12.1926	7.31	Yes	No	0	5	4
95	R:R:F391	R:R:L382	12.2766	2.44	No	No	0	6	5
96	R:R:F158	R:R:W200	17.7002	4.01	Yes	Yes	0	7	9
97	R:R:H165	R:R:W200	16.1551	4.23	Yes	Yes	2	8	9
98	R:R:D120	R:R:L116	22.5983	5.43	Yes	No	0	9	9
99	R:R:F158	R:R:L154	17.1326	3.65	Yes	Yes	0	7	5
100	R:R:D120	R:R:N92	39.3841	6.73	Yes	Yes	0	9	9
101	R:R:P211	R:R:Y153	18.1207	9.74	No	Yes	0	5	6
102	R:R:L157	R:R:Y153	10.1535	3.52	Yes	Yes	7	6	6
103	R:R:F243	R:R:W336	10.0378	4.01	Yes	Yes	1	8	8
104	R:R:L123	R:R:M128	30.0925	2.83	Yes	Yes	0	7	8
105	R:R:F112	R:R:H165	20.843	10.18	Yes	Yes	2	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	15.17	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V156	10.59	1	Yes	No	0	6	0	1
L:L:?1	R:R:S159	9.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:T160	2.99	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L229	4.22	1	Yes	No	0	4	0	1
L:L:?1	R:R:F234	4.95	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:G238	3.48	1	Yes	No	0	6	0	1
L:L:?1	R:R:S239	3.05	1	Yes	No	0	6	0	1
L:L:?1	R:R:S242	9.15	1	Yes	No	0	6	0	1
L:L:?1	R:R:F339	14.85	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	9.9	1	Yes	Yes	0	7	0	1
R:R:D155	R:R:V127	5.84	1	Yes	No	8	8	1	2
R:R:I152	R:R:I210	2.94	0	No	Yes	5	6	2	2
R:R:I152	R:R:L229	4.28	0	No	No	5	4	2	1
R:R:D155	R:R:S159	2.94	1	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	5.75	1	Yes	Yes	8	7	1	2
R:R:S207	R:R:V156	4.85	7	No	No	7	6	2	1
R:R:I210	R:R:V156	4.61	0	Yes	No	6	6	2	1
R:R:M164	R:R:T160	3.01	0	No	Yes	6	7	2	1
R:R:S203	R:R:T160	3.2	0	No	Yes	8	7	2	1
R:R:S242	R:R:T160	7.99	1	No	Yes	6	7	1	1
R:R:F234	R:R:P209	7.22	0	Yes	No	7	7	1	2
R:R:F234	R:R:I210	5.02	0	Yes	Yes	7	6	1	2
R:R:F340	R:R:S239	5.28	1	Yes	No	7	6	1	1
R:R:I344	R:R:S239	3.1	0	No	No	5	6	2	1
R:R:F243	R:R:W336	4.01	1	Yes	Yes	8	8	2	2
R:R:F243	R:R:F340	22.51	1	Yes	Yes	8	7	2	1
R:R:F339	R:R:W336	5.01	1	Yes	Yes	7	8	1	2
R:R:F340	R:R:W336	4.01	1	Yes	Yes	7	8	1	2
R:R:F339	R:R:F340	12.86	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	3.62	1	Yes	No	7	7	1	2
R:R:D231	R:R:F234	2.39	0	No	Yes	5	7	2	1
R:R:I206	R:R:T160	1.52	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LL8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.79
Number of Linked Nodes	246
Number of Links	270
Number of Hubs	36
Number of Links mediated by Hubs	140
Number of Communities	7
Number of Nodes involved in Communities	34
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	34241
Length Of Smallest Path	3
Average Path Length	12.0261
Length of Longest Path	30
Minimum Path Strength	1.3
Average Path Strength	6.04762
Maximum Path Strength	17.685
Minimum Path Correlation	0.7
Average Path Correlation	0.917877
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.5497
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.5996
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • protein tyrosine kinase activator activity • kinase activator activity • enzyme activator activity • molecular function activator activity • protein kinase activator activity • protein kinase regulator activity • kinase regulator activity • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • Gq/11-coupled serotonin receptor activity • identical protein binding • serotonin binding • amine binding • virus receptor activity • exogenous protein binding • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • response to xenobiotic stimulus • phospholipase C-activating serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of defense response • regulation of response to external stimulus • defense response • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • regulation of tube diameter • regulation of tube size • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • blood vessel diameter maintenance • vasoconstriction • blood circulation • regulation of anatomical structure size • protein localization to cytoskeleton • protein localization to organelle • glycerophospholipid metabolic process • positive regulation of phosphate metabolic process • phospholipid metabolic process • phosphate-containing compound metabolic process • positive regulation of phosphatidylinositol biosynthetic process • phosphorus metabolic process • regulation of phosphatidylinositol biosynthetic process • phosphatidylinositol metabolic process • positive regulation of phosphorus metabolic process • glycerophospholipid biosynthetic process • positive regulation of phospholipid biosynthetic process • regulation of phospholipid metabolic process • phospholipid biosynthetic process • regulation of phospholipid biosynthetic process • phosphatidylinositol biosynthetic process • positive regulation of phospholipid metabolic process • glycerolipid biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • regulation of phosphorus metabolic process • glycerolipid metabolic process • neuron apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • positive regulation of neuron apoptotic process • programmed cell death • regulation of neuron apoptotic process • behavior • learning or memory • nervous system process • cognition • memory • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • regulation of body fluid levels • homotypic cell-cell adhesion • regulation of cell activation • positive regulation of cell-cell adhesion • cell adhesion • cell-cell adhesion • coagulation • regulation of cell-cell adhesion • response to wounding • wound healing • regulation of homotypic cell-cell adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • regulation of platelet activation • regulation of platelet aggregation • positive regulation of homotypic cell-cell adhesion • positive regulation of platelet aggregation • platelet activation • ribonucleotide catabolic process • pyridine nucleotide catabolic process • aerobic respiration • oxoacid metabolic process • carbohydrate catabolic process • carbohydrate derivative metabolic process • organophosphate catabolic process • nucleoside phosphate catabolic process • organic acid metabolic process • nucleobase-containing compound metabolic process • glycolytic process • pyridine-containing compound metabolic process • purine ribonucleotide catabolic process • nucleoside phosphate metabolic process • nicotinamide nucleotide metabolic process • pyruvate metabolic process • purine nucleoside diphosphate metabolic process • purine-containing compound catabolic process • nucleotide metabolic process • nucleobase-containing compound catabolic process • nucleoside diphosphate metabolic process • purine nucleoside diphosphate catabolic process • nucleoside diphosphate catabolic process • nucleoside triphosphate metabolic process • monocarboxylic acid metabolic process • purine ribonucleotide metabolic process • pyridine-containing compound catabolic process • ribose phosphate metabolic process • cellular respiration • catabolic process • ATP metabolic process • energy derivation by oxidation of organic compounds • purine nucleotide metabolic process • ribonucleotide metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • ribonucleoside diphosphate metabolic process • ribonucleoside diphosphate catabolic process • nucleotide catabolic process • purine nucleoside triphosphate metabolic process • purine nucleotide catabolic process • carbohydrate metabolic process • carbohydrate derivative catabolic process • ADP catabolic process • carboxylic acid metabolic process • generation of precursor metabolites and energy • purine-containing compound metabolic process • ADP metabolic process • purine ribonucleoside diphosphate metabolic process • purine ribonucleoside diphosphate catabolic process • detection of external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of synaptic transmission, glutamatergic • smooth muscle contraction • urinary bladder smooth muscle contraction • urinary tract smooth muscle contraction • muscle contraction • developmental process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of potassium ion transport • regulation of potassium ion transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of cytosolic calcium ion concentration • regulation of heat generation • positive regulation of heat generation • heat generation • multicellular organismal-level homeostasis • temperature homeostasis • regulation of generation of precursor metabolites and energy • regulation of ATP metabolic process • regulation of purine nucleotide catabolic process • positive regulation of nucleotide catabolic process • regulation of nucleotide metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of carbohydrate catabolic process • regulation of purine nucleotide metabolic process • positive regulation of ATP metabolic process • regulation of nucleotide catabolic process • positive regulation of carbohydrate metabolic process • positive regulation of nucleotide metabolic process • positive regulation of purine nucleotide catabolic process • regulation of carbohydrate metabolic process • positive regulation of glycolytic process • regulation of catabolic process • regulation of glycolytic process • positive regulation of purine nucleotide metabolic process • positive regulation of catabolic process • adult behavior • behavioral response to cocaine • response to cocaine • response to alkaloid • detection of mechanical stimulus involved in sensory perception of pain • response to mechanical stimulus • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • learning • nonassociative learning • sensitization • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • dopamine transport • catecholamine transport • dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • calcium ion transmembrane import into cytosol • monoatomic ion transmembrane transport • calcium ion transport • monoatomic cation transmembrane transport • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • vascular associated smooth muscle contraction • artery smooth muscle contraction • tonic smooth muscle contraction • regulation of DNA biosynthetic process • positive regulation of macromolecule biosynthetic process • nucleic acid biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of DNA biosynthetic process • regulation of macromolecule metabolic process • DNA metabolic process • nucleobase-containing compound biosynthetic process • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of DNA metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • DNA biosynthetic process • regulation of DNA metabolic process • regulation of immune effector process • cytokine production • regulation of cytokine production • positive regulation of immune effector process • regulation of immune system process • cytokine production involved in immune response • positive regulation of immune system process • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune response • gene expression • immune effector process • regulation of gene expression • positive regulation of gene expression • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • positive regulation of cytokine production • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • G protein-coupled serotonin receptor complex • receptor complex • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • glutamatergic synapse • dendritic shaft • cell body • neuronal cell body • axon • membrane microdomain • membrane raft • plasma membrane raft • caveola • cell body fiber • cytoplasmic vesicle • intracellular vesicle • polymeric cytoskeletal fiber • neurofilament • intermediate filament cytoskeleton • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	91Q
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	91Q
Name	3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol
Synonyms
Identifier
Formula	C12 H16 N2 O
Molecular Weight	204.268
SMILES
PubChem	4980
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	0
Total Bonds	32
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9LL8_nogp_Chain_R L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.54	2025-04-02	10.1038/s41467-025-57956-7
	9AS8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.54	2025-04-02	10.1038/s41467-025-57956-7
	9LL9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.76	2026-01-14	To be published
	9LL9 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.76	2026-01-14	To be published
	9LLA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.27	2026-01-14	To be published
	9LLA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Ariadne	-		3.27	2026-01-14	To be published
	9LLB	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.98	2026-01-14	To be published
	9LLB (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI-NBOMe	-		2.98	2026-01-14	To be published
	9LL7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-	Gi1/β1/γ2	2.84	2026-01-14	To be published
	9LL7 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DOI	-		2.84	2026-01-14	To be published
	9LL8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	Gi1/β1/γ2	2.62	2026-01-14	To be published
	9LL8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-		2.62	2026-01-14	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LL8_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.