psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I40	R:R:L35	4.28	No	Yes	0	3	3
2	R:R:L300	R:R:L35	5.54	No	Yes	0	2	3
3	R:R:M39	R:R:P36	3.35	No	No	0	4	4
4	R:R:I40	R:R:L102	4.28	No	No	0	3	4
5	R:R:A44	R:R:F98	2.77	No	Yes	0	5	6
6	R:R:L94	R:R:Y47	4.69	Yes	No	6	7	7
7	R:R:F98	R:R:Y47	9.28	Yes	No	0	6	7
8	R:R:H306	R:R:Y47	6.53	Yes	No	6	6	7
9	R:R:L307	R:R:V50	2.98	No	No	0	5	7
10	R:R:I51	R:R:L94	7.14	No	Yes	0	7	7
11	R:R:L87	R:R:V55	2.98	No	No	0	8	7
12	R:R:G57	R:R:S56	3.71	No	No	0	8	5
13	R:R:N58	R:R:S83	2.98	No	No	0	9	9
14	R:R:D86	R:R:N58	13.46	No	No	0	9	9
15	R:R:L87	R:R:N58	6.87	No	No	0	8	9
16	R:R:I63	R:R:L59	2.85	No	No	0	3	4
17	R:R:I65	R:R:L61	4.28	Yes	Yes	2	7	9
18	R:R:I79	R:R:L61	2.85	No	Yes	2	8	9
19	R:R:L61	R:R:S83	4.5	Yes	No	0	9	9
20	R:R:G321	R:R:L61	3.42	No	Yes	0	7	9
21	R:R:I62	R:R:L66	2.85	No	No	0	7	4
22	R:R:I62	R:R:V80	4.61	No	No	0	7	5
23	R:R:D330	R:R:I64	5.6	No	No	0	5	7
24	R:R:I64	R:R:L331	4.28	No	No	0	7	5
25	R:R:I65	R:R:I79	2.94	Yes	No	2	7	8
26	R:R:I65	R:R:V80	4.61	Yes	No	0	7	5
27	R:R:F327	R:R:I65	7.54	Yes	Yes	0	8	7
28	R:R:D330	R:R:K67	11.06	No	No	0	5	5
29	R:R:F327	R:R:Q68	7.03	Yes	No	0	8	5
30	R:R:D330	R:R:Q68	7.83	No	No	0	5	5
31	R:R:E70	R:R:R72	3.49	No	No	0	5	6
32	R:R:E70	R:R:N73	13.15	No	No	0	5	8
33	R:R:I77	R:R:M71	2.92	Yes	No	0	5	7
34	R:R:N73	R:R:N76	13.62	No	No	0	8	8
35	R:R:E137	R:R:T75	7.06	No	No	0	8	7
36	R:R:F327	R:R:N76	4.83	Yes	No	0	8	8
37	R:R:I77	R:R:N152	2.83	Yes	No	7	5	2
38	R:R:I77	R:R:Y156	4.84	Yes	No	7	5	3
39	R:R:L133	R:R:L78	4.15	No	No	0	7	7
40	R:R:I134	R:R:L78	5.71	No	No	0	8	7
41	R:R:I79	R:R:Y320	3.63	No	Yes	2	8	9
42	R:R:N81	R:R:S130	2.98	No	No	0	9	8
43	R:R:I159	R:R:N81	8.5	No	No	0	7	9
44	R:R:N81	R:R:W163	6.78	No	No	0	9	9
45	R:R:L82	R:R:S127	3	Yes	No	0	9	9
46	R:R:L82	R:R:S130	7.51	Yes	No	0	9	8
47	R:R:L131	R:R:L82	4.15	No	Yes	2	8	9
48	R:R:L82	R:R:N316	12.36	Yes	No	2	9	9
49	R:R:S85	R:R:V126	4.85	No	No	0	8	7
50	R:R:S127	R:R:S85	4.89	No	No	0	9	8
51	R:R:D86	R:R:T313	10.12	No	No	0	9	8
52	R:R:D86	R:R:N316	8.08	No	No	0	9	9
53	R:R:L88	R:R:M92	2.83	No	No	0	7	5
54	R:R:L88	R:R:S123	4.5	No	No	0	7	8
55	R:R:C93	R:R:V89	5.12	No	No	0	7	7
56	R:R:S123	R:R:V89	3.23	No	No	0	8	7
57	R:R:I124	R:R:V89	3.07	Yes	No	0	7	7
58	R:R:I91	R:R:M92	4.37	No	No	0	5	5
59	R:R:C93	R:R:Q120	9.16	No	No	0	7	6
60	R:R:H306	R:R:L94	3.86	Yes	Yes	6	6	7
61	R:R:L94	R:R:M310	11.31	Yes	No	6	7	7
62	R:R:F96	R:R:P95	4.33	No	No	0	6	8
63	R:R:F96	R:R:N116	10.87	No	No	0	6	5
64	R:R:H306	R:R:T97	5.48	Yes	No	0	6	6
65	L:L:P34	R:R:T97	6.99	No	No	0	0	6
66	R:R:F98	R:R:L102	13.4	Yes	No	0	6	4
67	R:R:M103	R:R:V99	3.04	No	No	0	3	4
68	R:R:F108	R:R:V99	7.87	Yes	No	0	7	4
69	R:R:W106	R:R:Y100	5.79	Yes	No	0	8	6
70	L:L:P34	R:R:Y100	5.56	No	No	0	0	6
71	R:R:N299	R:R:T101	4.39	Yes	No	8	4	4
72	R:R:F302	R:R:T101	2.59	No	No	0	5	4
73	R:R:L303	R:R:T101	7.37	No	No	8	4	4
74	R:R:H105	R:R:M103	6.57	No	No	0	5	3
75	R:R:D104	R:R:H105	7.56	No	No	9	4	5
76	R:R:D104	R:R:K195	5.53	No	No	9	4	3
77	L:L:I28	R:R:D104	2.8	No	No	0	0	4
78	R:R:H105	R:R:K195	24.89	No	No	9	5	3
79	R:R:F108	R:R:W106	7.02	Yes	Yes	0	7	8
80	R:R:C113	R:R:W106	6.53	No	Yes	5	9	8
81	R:R:M179	R:R:W106	4.65	Yes	Yes	5	4	8
82	R:R:W106	R:R:Y196	2.89	Yes	No	5	8	5
83	R:R:C198	R:R:W106	3.92	Yes	Yes	5	9	8
84	R:R:F108	R:R:V107	2.62	Yes	No	0	7	2
85	R:R:F108	R:R:M112	3.73	Yes	No	0	7	6
86	R:R:G109	R:R:M112	3.49	No	No	0	8	6
87	R:R:E110	R:R:M179	6.77	No	Yes	0	3	4
88	R:R:C113	R:R:C198	3.64	No	Yes	5	9	9
89	R:R:K114	R:R:L174	2.82	No	No	0	7	5
90	R:R:K114	R:R:Q177	9.49	No	No	0	7	5
91	R:R:N116	R:R:Q120	6.6	No	No	0	5	6
92	R:R:F118	R:R:V167	2.62	Yes	No	0	6	4
93	R:R:F118	R:R:S170	2.64	Yes	Yes	0	6	7
94	R:R:F118	R:R:L171	4.87	Yes	No	0	6	4
95	R:R:F118	R:R:L174	13.4	Yes	No	0	6	5
96	R:R:C121	R:R:S170	6.89	No	Yes	0	4	7
97	R:R:C121	R:R:F173	2.79	No	Yes	0	4	5
98	R:R:V122	R:R:V167	3.21	No	No	0	5	4
99	R:R:S170	R:R:V122	4.85	Yes	No	0	7	5
100	R:R:I124	R:R:Q219	4.12	Yes	Yes	1	7	6
101	R:R:I124	R:R:W276	5.87	Yes	No	0	7	8
102	L:L:Y36	R:R:I124	4.84	No	Yes	1	0	7
103	R:R:F129	R:R:T125	2.59	Yes	Yes	0	7	6
104	R:R:A166	R:R:T125	3.36	No	Yes	0	8	6
105	R:R:S169	R:R:T125	3.2	No	Yes	0	5	6
106	R:R:Q219	R:R:T125	4.25	Yes	Yes	0	6	6
107	R:R:V126	R:R:W163	12.26	No	No	0	7	9
108	R:R:I128	R:R:Q219	4.12	No	Yes	0	7	6
109	R:R:I128	R:R:P223	3.39	No	No	0	7	9
110	R:R:F129	R:R:I162	2.51	Yes	No	0	7	7
111	R:R:L131	R:R:N316	4.12	No	No	2	8	9
112	R:R:L131	R:R:Y320	4.69	No	Yes	2	8	9
113	R:R:P223	R:R:V132	3.53	No	No	0	9	7
114	R:R:I162	R:R:L133	2.85	No	No	0	7	7
115	R:R:I134	R:R:R138	3.76	No	No	2	8	9
116	R:R:I134	R:R:Y320	6.04	No	Yes	2	8	9
117	R:R:A135	R:R:I227	4.87	No	No	3	9	8
118	R:R:A135	R:R:Y231	4	No	Yes	3	9	9
119	R:R:F226	R:R:V136	3.93	No	No	0	6	6
120	R:R:E137	R:R:L141	3.98	No	No	0	8	8
121	R:R:R138	R:R:Y320	4.12	No	Yes	2	9	9
122	R:R:H139	R:R:I143	14.58	Yes	Yes	3	7	6
123	R:R:C230	R:R:H139	7.37	No	Yes	0	7	7
124	R:R:H139	R:R:K233	10.48	Yes	No	0	7	4
125	R:R:H139	R:R:I234	3.98	Yes	Yes	3	7	8
126	R:R:N144	R:R:Q140	5.28	No	No	0	6	4
127	R:R:L141	R:R:R149	3.64	No	No	0	8	5
128	R:R:I142	R:R:I234	4.42	No	Yes	0	8	8
129	R:R:I143	R:R:N144	4.25	Yes	No	0	6	6
130	R:R:I143	R:R:I234	2.94	Yes	Yes	3	6	8
131	R:R:I143	R:R:R237	2.51	Yes	No	0	6	5
132	R:R:P145	R:R:R146	2.88	No	No	0	8	6
133	R:R:P150	R:R:W148	9.46	No	No	0	6	5
134	R:R:H154	R:R:W148	7.41	No	No	0	4	5
135	R:R:P150	R:R:R149	2.88	No	No	0	6	5
136	R:R:H154	R:R:N151	3.83	No	No	0	4	7
137	R:R:N152	R:R:Y156	3.49	No	No	7	2	3
138	R:R:S169	R:R:S170	3.26	No	Yes	0	5	7
139	R:R:I175	R:R:L171	5.71	No	No	0	4	4
140	R:R:P172	R:R:Y211	9.74	No	No	0	8	6
141	R:R:D200	R:R:F173	8.36	No	Yes	1	4	5
142	R:R:F173	R:R:F202	5.36	Yes	Yes	1	5	5
143	R:R:F173	R:R:Y211	15.47	Yes	No	1	5	6
144	L:L:R35	R:R:F173	4.28	Yes	Yes	1	0	5
145	R:R:F202	R:R:Y176	4.13	Yes	No	0	5	5
146	R:R:P203	R:R:Y176	13.91	No	No	0	5	5
147	R:R:C198	R:R:Q177	6.1	Yes	No	0	9	5
148	R:R:T180	R:R:V178	4.76	Yes	No	4	3	5
149	R:R:F199	R:R:V178	5.24	Yes	No	4	3	5
150	R:R:Q201	R:R:V178	4.3	No	No	4	3	5
151	R:R:M179	R:R:Y196	5.99	Yes	No	5	4	5
152	R:R:C198	R:R:M179	4.86	Yes	Yes	5	9	4
153	R:R:E182	R:R:T180	4.23	No	Yes	4	1	3
154	R:R:P183	R:R:T180	6.99	No	Yes	4	1	3
155	R:R:F199	R:R:T180	3.89	Yes	Yes	4	3	3
156	R:R:D181	R:R:D194	3.99	No	No	0	1	5
157	R:R:D181	R:R:Y196	12.64	No	No	0	1	5
158	R:R:E182	R:R:P183	17.29	No	No	4	1	1
159	R:R:F199	R:R:P183	2.89	Yes	No	4	3	1
160	R:R:F184	R:R:K193	4.96	Yes	No	0	1	2
161	R:R:F184	R:R:K195	8.69	Yes	No	0	1	3
162	R:R:F184	R:R:V197	3.93	Yes	No	0	1	4
163	L:L:I28	R:R:F184	6.28	No	Yes	0	0	1
164	R:R:L189	R:R:Q185	6.65	No	No	0	5	2
165	R:R:D194	R:R:Q185	3.92	No	No	0	5	2
166	R:R:N186	R:R:V187	8.87	No	No	0	1	2
167	L:L:K4	R:R:N186	6.99	No	No	0	0	1
168	R:R:T188	R:R:V187	6.35	No	No	0	3	2
169	L:L:P8	R:R:V187	3.53	No	No	0	0	2
170	L:L:Y20	R:R:T188	7.49	Yes	No	0	0	3
171	L:L:L24	R:R:L189	2.77	No	No	0	0	5
172	R:R:F199	R:R:V197	5.24	Yes	No	0	3	4
173	R:R:F199	R:R:Q201	7.03	Yes	No	4	3	3
174	L:L:Y1	R:R:F199	5.16	No	Yes	0	0	3
175	R:R:D200	R:R:F202	15.52	No	Yes	1	4	5
176	R:R:F202	R:R:R208	8.55	Yes	No	0	5	4
177	R:R:F202	R:R:Y211	3.09	Yes	No	1	5	6
178	R:R:S204	R:R:S206	4.89	No	No	0	3	1
179	R:R:H207	R:R:S204	11.16	No	No	0	3	3
180	R:R:D205	R:R:R208	9.53	No	No	0	1	4
181	R:R:D205	R:R:L209	4.07	No	No	0	1	3
182	L:L:Y1	R:R:R208	8.23	No	No	0	0	4
183	R:R:L209	R:R:W288	13.67	No	No	0	3	4
184	R:R:D287	R:R:T212	8.67	Yes	No	1	4	5
185	L:L:R35	R:R:T212	5.17	Yes	No	1	0	5
186	R:R:L216	R:R:T213	4.42	No	No	0	6	5
187	R:R:L215	R:R:Q219	3.99	No	Yes	0	5	6
188	L:L:Y36	R:R:Q219	7.89	No	Yes	1	0	6
189	R:R:F221	R:R:Y220	6.19	No	Yes	0	5	8
190	R:R:L224	R:R:Y220	3.52	No	Yes	0	6	8
191	R:R:L277	R:R:Y220	7.03	No	Yes	0	6	8
192	R:R:T280	R:R:Y220	3.75	No	Yes	0	8	8
193	R:R:G222	R:R:P223	4.06	No	No	0	5	9
194	R:R:F272	R:R:L224	4.87	No	No	0	9	6
195	R:R:C230	R:R:F226	4.19	No	No	0	7	6
196	R:R:I227	R:R:Y231	9.67	No	Yes	3	8	9
197	R:R:L265	R:R:Y231	8.21	No	Yes	0	8	9
198	R:R:I268	R:R:Y231	4.84	No	Yes	0	7	9
199	R:R:V269	R:R:Y231	2.52	No	Yes	0	8	9
200	R:R:F232	R:R:I236	12.56	No	No	0	4	3
201	R:R:I236	R:R:Y235	3.63	No	No	0	3	5
202	R:R:K239	R:R:Y235	7.17	No	No	0	4	5
203	R:R:N262	R:R:Y235	9.3	No	No	0	6	5
204	R:R:R237	R:R:R240	7.46	No	No	0	5	4
205	R:R:R237	R:R:R241	4.26	No	No	0	5	6
206	R:R:L238	R:R:R241	3.64	No	No	0	8	6
207	R:R:I261	R:R:L238	4.28	No	No	0	7	8
208	R:R:R241	R:R:R254	12.79	No	Yes	0	6	4
209	R:R:N242	R:R:T258	5.85	No	No	0	3	7
210	R:R:M245	R:R:M248	5.78	No	No	10	5	4
211	R:R:M245	R:R:R254	6.2	No	Yes	0	5	4
212	R:R:D246	R:R:D250	5.32	No	No	0	4	3
213	R:R:N251	R:R:Y253	3.49	No	No	0	3	3
214	R:R:E257	R:R:Y253	12.35	No	No	0	6	3
215	R:R:I268	R:R:M264	2.92	No	No	0	7	8
216	R:R:L266	R:R:V270	2.98	No	No	0	5	5
217	R:R:F319	R:R:S267	7.93	Yes	No	0	8	5
218	R:R:F319	R:R:I268	6.28	Yes	No	0	8	7
219	R:R:A271	R:R:F319	2.77	No	Yes	0	7	8
220	R:R:F272	R:R:W276	7.02	No	No	0	9	8
221	R:R:C275	R:R:S312	3.44	No	No	0	8	9
222	R:R:S312	R:R:W276	7.41	No	No	0	9	8
223	R:R:L277	R:R:P278	3.28	No	No	0	6	9
224	R:R:P278	R:R:T308	6.99	No	No	0	9	7
225	R:R:L279	R:R:N283	2.75	No	No	0	7	5
226	R:R:A309	R:R:L279	3.15	No	No	0	8	7
227	R:R:F282	R:R:F302	12.86	No	No	0	5	5
228	R:R:C305	R:R:F282	4.19	No	No	0	6	5
229	L:L:R33	R:R:N283	3.62	No	No	0	0	5
230	L:L:R35	R:R:N283	9.64	Yes	No	0	0	5
231	R:R:D287	R:R:F286	3.58	Yes	No	0	4	4
232	L:L:P2	R:R:F286	2.89	Yes	No	0	0	4
233	L:L:R33	R:R:F286	12.83	No	No	0	0	4
234	R:R:D287	R:R:W288	3.35	Yes	No	0	4	4
235	L:L:R35	R:R:D287	4.76	Yes	Yes	1	0	4
236	R:R:N289	R:R:Q291	3.96	No	No	11	4	2
237	R:R:I292	R:R:N289	7.08	No	No	11	4	4
238	R:R:H290	R:R:Q291	4.95	No	No	0	4	2
239	L:L:P2	R:R:H290	3.05	Yes	No	0	0	4
240	R:R:I292	R:R:Q291	2.74	No	No	11	4	2
241	L:L:H26	R:R:A294	2.93	No	No	0	0	1
242	R:R:N297	R:R:T295	7.31	No	No	0	3	1
243	L:L:R25	R:R:C296	2.79	No	No	0	0	2
244	R:R:H298	R:R:N299	3.83	Yes	Yes	0	3	4
245	L:L:N29	R:R:H298	3.83	No	Yes	0	0	3
246	L:L:L30	R:R:H298	3.86	No	Yes	0	0	3
247	R:R:L303	R:R:N299	2.75	No	Yes	8	4	4
248	L:L:T32	R:R:N299	2.92	No	Yes	0	0	4
249	L:L:R33	R:R:F302	18.17	No	No	0	0	5
250	R:R:H306	R:R:M310	10.51	Yes	No	6	6	7
251	R:R:I311	R:R:L307	2.85	No	No	0	6	5
252	R:R:I318	R:R:V315	4.61	No	No	0	6	6
253	R:R:F319	R:R:I318	5.02	Yes	No	0	8	6
254	R:R:F322	R:R:I318	3.77	No	No	0	6	6
255	R:R:F327	R:R:N324	12.08	Yes	No	0	8	8
256	R:R:K325	R:R:Q328	2.71	Yes	No	0	5	8
257	R:R:Q328	R:R:Q332	3.84	No	No	0	8	4
258	R:R:Q332	R:R:R329	3.5	No	No	0	4	5
259	L:L:P2	L:L:Y1	6.95	Yes	No	0	0	0
260	L:L:P2	L:L:Y27	2.78	Yes	No	0	0	0
261	L:L:L30	L:L:P2	6.57	No	Yes	0	0	0
262	L:L:K4	L:L:P5	5.02	No	No	0	0	0
263	L:L:N7	L:L:P5	9.77	No	No	0	0	0
264	L:L:N7	L:L:Y20	4.65	No	Yes	0	0	0
265	L:L:A23	L:L:N7	4.69	No	No	0	0	0
266	L:L:P8	L:L:Y20	12.52	No	Yes	0	0	0
267	L:L:D16	L:L:R19	9.53	No	No	0	0	0
268	L:L:A18	L:L:R19	4.15	No	No	0	0	0
269	L:L:R19	L:L:S22	2.64	No	No	0	0	0
270	L:L:I28	L:L:L24	4.28	No	No	0	0	0
271	L:L:N29	L:L:R25	3.62	No	No	0	0	0
272	L:L:L31	L:L:Y27	10.55	No	No	0	0	0
273	L:L:N29	L:L:T32	2.92	No	No	0	0	0
274	L:L:R35	L:L:Y36	6.17	Yes	No	1	0	0
275	R:R:F98	R:R:L43	2.44	Yes	No	0	6	7
276	R:R:F129	R:R:L165	2.44	Yes	No	0	7	5
277	R:R:F129	R:R:L218	2.44	Yes	No	0	7	5
278	R:R:F282	R:R:L301	2.44	No	No	0	5	6
279	R:R:F322	R:R:L331	2.44	No	No	0	6	5
280	R:R:I234	R:R:Y231	2.42	Yes	Yes	3	8	9
281	R:R:N251	R:R:R254	2.41	No	Yes	0	3	4
282	R:R:G158	R:R:V161	1.84	No	No	0	5	4
283	R:R:P150	R:R:V74	1.77	No	No	0	6	6
284	R:R:G48	R:R:I51	1.76	No	No	0	5	7
285	R:R:G54	R:R:L53	1.71	No	No	0	7	5
286	L:L:A23	L:L:S22	1.71	No	No	0	0	0
287	R:R:A155	R:R:V74	1.7	No	No	0	7	6
288	R:R:A90	R:R:T313	1.68	No	No	0	7	8
289	R:R:L35	R:R:P36	1.64	Yes	No	0	3	4
290	R:R:L61	R:R:P317	1.64	Yes	No	0	9	9
291	R:R:C230	R:R:I229	1.64	No	No	0	7	4
292	R:R:C275	R:R:I311	1.64	No	No	0	8	6
293	R:R:N116	R:R:P117	1.63	No	No	0	5	6
294	R:R:N144	R:R:P145	1.63	No	No	0	6	8
295	R:R:S123	R:R:V119	1.62	No	No	0	8	5
296	R:R:V157	R:R:V161	1.6	No	No	0	3	4
297	R:R:S255	R:R:T258	1.6	No	No	0	4	7
298	R:R:V270	R:R:V274	1.6	No	No	0	5	6
299	R:R:A46	R:R:L307	1.58	No	No	0	6	5
300	R:R:A155	R:R:L78	1.58	No	No	0	7	7
301	R:R:A273	R:R:L224	1.58	No	No	0	6	6
302	R:R:T280	R:R:T284	1.57	No	No	0	8	6
303	R:R:I52	R:R:V55	1.54	No	No	0	5	7
304	R:R:A191	R:R:D190	1.54	No	No	0	3	1
305	R:R:I293	R:R:V285	1.54	No	No	0	3	4
306	R:R:K252	R:R:S255	1.53	No	No	0	2	4
307	R:R:I293	R:R:T295	1.52	No	No	0	3	1
308	R:R:L216	R:R:V217	1.49	No	No	0	6	5
309	R:R:I62	R:R:I63	1.47	No	No	0	7	3
310	R:R:I159	R:R:I77	1.47	No	Yes	0	7	5
311	R:R:L216	R:R:T284	1.47	No	No	0	6	6
312	L:L:H26	R:R:C296	1.47	No	No	0	0	2
313	R:R:I52	R:R:L53	1.43	No	No	0	5	5
314	R:R:I261	R:R:N262	1.42	No	No	0	7	6
315	R:R:K259	R:R:N262	1.4	No	No	0	6	6
316	R:R:K325	R:R:N324	1.4	Yes	No	0	5	8
317	R:R:K325	R:R:N326	1.4	Yes	No	0	5	6
318	R:R:L304	R:R:L43	1.38	No	No	0	6	7
319	R:R:L115	R:R:L174	1.38	No	No	0	5	5
320	R:R:L301	R:R:L304	1.38	No	No	0	6	6
321	R:R:H298	R:R:T295	1.37	Yes	No	0	3	1
322	R:R:D246	R:R:N242	1.35	No	No	0	4	3
323	R:R:D246	R:R:N243	1.35	No	No	0	4	4
324	R:R:H34	R:R:L35	1.29	No	Yes	0	2	3
325	R:R:R254	R:R:T258	1.29	Yes	No	0	4	7
326	R:R:M245	R:R:R249	1.24	No	No	10	5	4
327	R:R:M248	R:R:R249	1.24	No	No	10	4	4
328	R:R:K325	R:R:R260	1.24	Yes	No	0	5	7
329	R:R:F322	R:R:L323	1.22	No	No	0	6	6
330	R:R:N152	R:R:R153	1.21	No	No	0	2	5
331	L:L:M17	L:L:Y20	1.2	No	Yes	0	0	0
332	R:R:D194	R:R:Y192	1.15	No	No	0	5	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L35	3.1875	4	0	3
2	R:R:L61	3.338	5	2	9
3	R:R:I65	4.8425	4	2	7
4	R:R:I77	3.015	4	7	5
5	R:R:L82	6.755	4	2	9
6	R:R:L94	6.75	4	6	7
7	R:R:F98	6.9725	4	0	6
8	R:R:W106	5.13333	6	5	8
9	R:R:F108	5.31	4	0	7
10	R:R:F118	5.8825	4	0	6
11	R:R:I124	4.475	4	1	7
12	R:R:T125	3.35	4	0	6
13	R:R:F129	2.495	4	0	7
14	R:R:H139	9.1025	4	3	7
15	R:R:I143	6.07	4	3	6
16	R:R:S170	4.41	4	0	7
17	R:R:F173	7.252	5	1	5
18	R:R:M179	5.5675	4	5	4
19	R:R:T180	4.9675	4	4	3
20	R:R:F184	5.965	4	0	1
21	R:R:C198	4.63	4	5	9
22	R:R:F199	4.90833	6	4	3
23	R:R:F202	7.33	5	1	5
24	R:R:Q219	4.874	5	1	6
25	R:R:Y220	5.1225	4	0	8
26	R:R:Y231	5.27667	6	3	9
27	R:R:I234	3.44	4	3	8
28	R:R:R254	5.6725	4	0	4
29	R:R:D287	5.09	4	1	4
30	R:R:H298	3.2225	4	0	3
31	R:R:N299	3.4725	4	8	4
32	R:R:H306	6.595	4	6	6
33	R:R:F319	5.5	4	0	8
34	R:R:Y320	4.62	4	2	9
35	R:R:K325	1.6875	4	0	5
36	R:R:F327	7.87	4	0	8
37	L:L:P2	4.448	5	0	0
38	L:L:Y20	6.465	4	0	0
39	L:L:R35	6.004	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F98	R:R:L43	13.6337	2.44	Yes	No	0	6	7
2	R:R:L304	R:R:L43	14.3883	1.38	No	No	0	6	7
3	R:R:L301	R:R:L304	15.1759	1.38	No	No	0	6	6
4	R:R:F282	R:R:L301	15.9784	2.44	No	No	0	5	6
5	R:R:F282	R:R:F302	17.6126	12.86	No	No	0	5	5
6	L:L:R33	R:R:F302	19.9242	18.17	No	No	0	0	5
7	L:L:R33	R:R:N283	18.3157	3.62	No	No	0	0	5
8	L:L:R35	R:R:N283	19.7328	9.64	Yes	No	0	0	5
9	L:L:R35	L:L:Y36	62.5331	6.17	Yes	No	1	0	0
10	L:L:Y36	R:R:I124	12.9932	4.84	No	Yes	1	0	7
11	R:R:I124	R:R:W276	21.345	5.87	Yes	No	0	7	8
12	L:L:Y36	R:R:Q219	49.7534	7.89	No	Yes	1	0	6
13	R:R:Q219	R:R:T125	71.0431	4.25	Yes	Yes	0	6	6
14	R:R:F129	R:R:T125	100	2.59	Yes	Yes	0	7	6
15	R:R:F129	R:R:I162	99.0614	2.51	Yes	No	0	7	7
16	R:R:I162	R:R:L133	98.7338	2.85	No	No	0	7	7
17	R:R:L133	R:R:L78	98.3988	4.15	No	No	0	7	7
18	R:R:I134	R:R:L78	94.2874	5.71	No	No	0	8	7
19	R:R:I134	R:R:Y320	93.0249	6.04	No	Yes	2	8	9
20	R:R:I79	R:R:Y320	77.0465	3.63	No	Yes	2	8	9
21	R:R:L87	R:R:N58	10.2842	6.87	No	No	0	8	9
22	R:R:L131	R:R:Y320	24.6908	4.69	No	Yes	2	8	9
23	R:R:I65	R:R:I79	67.7746	2.94	Yes	No	2	7	8
24	R:R:D330	R:R:Q68	57.1996	7.83	No	No	0	5	5
25	R:R:F327	R:R:Q68	58.0131	7.03	Yes	No	0	8	5
26	R:R:F327	R:R:I65	67.1673	7.54	Yes	Yes	0	8	7
27	R:R:D330	R:R:I64	55.5506	5.6	No	No	0	5	7
28	R:R:I64	R:R:L331	54.7151	4.28	No	No	0	7	5
29	R:R:L131	R:R:L82	14.8299	4.15	No	Yes	2	8	9
30	R:R:L82	R:R:S130	10.6964	7.51	Yes	No	0	9	8
31	R:R:A155	R:R:V74	10.8731	1.7	No	No	0	7	6
32	R:R:A155	R:R:L78	12.0546	1.58	No	No	0	7	7
33	R:R:I124	R:R:V89	13.1589	3.07	Yes	No	0	7	7
34	R:R:C198	R:R:W106	14.9735	3.92	Yes	Yes	5	9	8
35	R:R:C198	R:R:Q177	21.9155	6.1	Yes	No	0	9	5
36	R:R:K114	R:R:Q177	22.6332	9.49	No	No	0	7	5
37	R:R:K114	R:R:L174	23.3804	2.82	No	No	0	7	5
38	R:R:F118	R:R:L174	24.8896	13.4	Yes	No	0	6	5
39	L:L:R35	R:R:F173	21.1536	4.28	Yes	Yes	1	0	5
40	R:R:C121	R:R:F173	18.4224	2.79	No	Yes	0	4	5
41	R:R:C121	R:R:S170	18.566	6.89	No	Yes	0	4	7
42	R:R:S169	R:R:S170	39.4803	3.26	No	Yes	0	5	7
43	R:R:S169	R:R:T125	39.7747	3.2	No	Yes	0	5	6
44	R:R:I268	R:R:Y231	45.9401	4.84	No	Yes	0	7	9
45	R:R:F319	R:R:I268	47.7658	6.28	Yes	No	0	8	7
46	R:R:F319	R:R:I318	50.427	5.02	Yes	No	0	8	6
47	R:R:F322	R:R:I318	52.1643	3.77	No	No	0	6	6
48	R:R:F322	R:R:L331	53.8722	2.44	No	No	0	6	5
49	R:R:I234	R:R:Y231	41.2839	2.42	Yes	Yes	3	8	9
50	R:R:I143	R:R:I234	32.8438	2.94	Yes	Yes	3	6	8
51	R:R:I143	R:R:R237	28.3643	2.51	Yes	No	0	6	5
52	R:R:F173	R:R:F202	28.6293	5.36	Yes	Yes	1	5	5
53	L:L:P2	R:R:F286	27.5324	2.89	Yes	No	0	0	4
54	L:L:P2	L:L:Y1	18.415	6.95	Yes	No	0	0	0
55	L:L:Y1	R:R:F199	36.7307	5.16	No	Yes	0	0	3
56	R:R:F184	R:R:V197	21.448	3.93	Yes	No	0	1	4
57	R:R:F199	R:R:V197	23.3657	5.24	Yes	No	0	3	4
58	L:L:Y1	R:R:R208	24.0099	8.23	No	No	0	0	4
59	R:R:D287	R:R:F286	25.957	3.58	Yes	No	0	4	4
60	R:R:F272	R:R:W276	14.2079	7.02	No	No	0	9	8
61	R:R:F272	R:R:L224	13.1589	4.87	No	No	0	9	6
62	R:R:L224	R:R:Y220	11.0387	3.52	No	Yes	0	6	8
63	R:R:R237	R:R:R241	26.2588	4.26	No	No	0	5	6
64	R:R:R241	R:R:R254	16.4605	12.79	No	Yes	0	6	4
65	L:L:L30	R:R:H298	10.7148	3.86	No	Yes	0	0	3
66	L:L:L30	L:L:P2	11.5798	6.57	No	Yes	0	0	0
67	R:R:F118	R:R:S170	27.7827	2.64	Yes	Yes	0	6	7
68	R:R:I124	R:R:Q219	20.6456	4.12	Yes	Yes	1	7	6
69	R:R:F202	R:R:R208	25.7251	8.55	Yes	No	0	5	4
70	L:L:R35	R:R:D287	27.7532	4.76	Yes	Yes	1	0	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I124	R:R:V89	3.07	1	Yes	No	7	7	1	2
R:R:H306	R:R:T97	5.48	6	Yes	No	6	6	2	1
L:L:P34	R:R:T97	6.99	0	No	No	0	6	0	1
R:R:W106	R:R:Y100	5.79	5	Yes	No	8	6	2	1
L:L:P34	R:R:Y100	5.56	0	No	No	0	6	0	1
R:R:N299	R:R:T101	4.39	8	Yes	No	4	4	1	2
R:R:F302	R:R:T101	2.59	0	No	No	5	4	1	2
R:R:L303	R:R:T101	7.37	8	No	No	4	4	2	2
R:R:D104	R:R:H105	7.56	9	No	No	4	5	1	2
R:R:D104	R:R:K195	5.53	9	No	No	4	3	1	2
L:L:I28	R:R:D104	2.8	0	No	No	0	4	0	1
R:R:H105	R:R:K195	24.89	9	No	No	5	3	2	2
R:R:C121	R:R:F173	2.79	0	No	Yes	4	5	2	1
R:R:I124	R:R:Q219	4.12	1	Yes	Yes	7	6	1	1
R:R:I124	R:R:W276	5.87	1	Yes	No	7	8	1	2
L:L:Y36	R:R:I124	4.84	1	No	Yes	0	7	0	1
R:R:Q219	R:R:T125	4.25	1	Yes	Yes	6	6	1	2
R:R:I128	R:R:Q219	4.12	0	No	Yes	7	6	2	1
R:R:D200	R:R:F173	8.36	1	No	Yes	4	5	2	1
R:R:F173	R:R:F202	5.36	1	Yes	Yes	5	5	1	2
R:R:F173	R:R:Y211	15.47	1	Yes	No	5	6	1	2
L:L:R35	R:R:F173	4.28	1	Yes	Yes	0	5	0	1
R:R:T180	R:R:V178	4.76	4	Yes	No	3	5	2	2
R:R:F199	R:R:V178	5.24	4	Yes	No	3	5	1	2
R:R:Q201	R:R:V178	4.3	4	No	No	3	5	2	2
R:R:P183	R:R:T180	6.99	4	No	Yes	1	3	2	2
R:R:F199	R:R:T180	3.89	4	Yes	Yes	3	3	1	2
R:R:F199	R:R:P183	2.89	4	Yes	No	3	1	1	2
R:R:F184	R:R:K193	4.96	0	Yes	No	1	2	1	2
R:R:F184	R:R:K195	8.69	0	Yes	No	1	3	1	2
R:R:F184	R:R:V197	3.93	0	Yes	No	1	4	1	2
L:L:I28	R:R:F184	6.28	0	No	Yes	0	1	0	1
R:R:L189	R:R:Q185	6.65	0	No	No	5	2	1	2
R:R:N186	R:R:V187	8.87	0	No	No	1	2	1	1
L:L:K4	R:R:N186	6.99	0	No	No	0	1	0	1
R:R:T188	R:R:V187	6.35	0	No	No	3	2	1	1
L:L:P8	R:R:V187	3.53	0	No	No	0	2	0	1
L:L:Y20	R:R:T188	7.49	0	Yes	No	0	3	0	1
L:L:L24	R:R:L189	2.77	0	No	No	0	5	0	1
R:R:F199	R:R:V197	5.24	4	Yes	No	3	4	1	2
R:R:F199	R:R:Q201	7.03	4	Yes	No	3	3	1	2
L:L:Y1	R:R:F199	5.16	0	No	Yes	0	3	0	1
R:R:D200	R:R:F202	15.52	1	No	Yes	4	5	2	2
R:R:F202	R:R:R208	8.55	1	Yes	No	5	4	2	1
R:R:F202	R:R:Y211	3.09	1	Yes	No	5	6	2	2
R:R:D205	R:R:R208	9.53	0	No	No	1	4	2	1
L:L:Y1	R:R:R208	8.23	0	No	No	0	4	0	1
R:R:D287	R:R:T212	8.67	1	Yes	No	4	5	1	1
L:L:R35	R:R:T212	5.17	1	Yes	No	0	5	0	1
R:R:L215	R:R:Q219	3.99	0	No	Yes	5	6	2	1
L:L:Y36	R:R:Q219	7.89	1	No	Yes	0	6	0	1
R:R:L279	R:R:N283	2.75	0	No	No	7	5	2	1
R:R:F282	R:R:F302	12.86	0	No	No	5	5	2	1
L:L:R33	R:R:N283	3.62	0	No	No	0	5	0	1
L:L:R35	R:R:N283	9.64	1	Yes	No	0	5	0	1
R:R:D287	R:R:F286	3.58	1	Yes	No	4	4	1	1
L:L:P2	R:R:F286	2.89	0	Yes	No	0	4	0	1
L:L:R33	R:R:F286	12.83	0	No	No	0	4	0	1
R:R:D287	R:R:W288	3.35	1	Yes	No	4	4	1	2
L:L:R35	R:R:D287	4.76	1	Yes	Yes	0	4	0	1
R:R:H290	R:R:Q291	4.95	0	No	No	4	2	1	2
L:L:P2	R:R:H290	3.05	0	Yes	No	0	4	0	1
L:L:H26	R:R:A294	2.93	0	No	No	0	1	0	1
L:L:R25	R:R:C296	2.79	0	No	No	0	2	0	1
R:R:H298	R:R:N299	3.83	0	Yes	Yes	3	4	1	1
L:L:N29	R:R:H298	3.83	0	No	Yes	0	3	0	1
L:L:L30	R:R:H298	3.86	0	No	Yes	0	3	0	1
R:R:L303	R:R:N299	2.75	8	No	Yes	4	4	2	1
L:L:T32	R:R:N299	2.92	0	No	Yes	0	4	0	1
L:L:R33	R:R:F302	18.17	0	No	No	0	5	0	1
L:L:H26	R:R:C296	1.47	0	No	No	0	2	0	1
R:R:H298	R:R:T295	1.37	0	Yes	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8K6O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.51
Number of Linked Nodes	301
Number of Links	332
Number of Hubs	39
Number of Links mediated by Hubs	148
Number of Communities	11
Number of Nodes involved in Communities	55
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	48710
Length Of Smallest Path	3
Average Path Length	18.7064
Length of Longest Path	45
Minimum Path Strength	1.32
Average Path Strength	5.06377
Maximum Path Strength	16.79
Minimum Path Correlation	0.7
Average Path Correlation	0.938099
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	48.9308
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.4423
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • pancreatic polypeptide receptor activity • peptide receptor activity • molecular transducer activity • neuropeptide Y receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • neuropeptide binding • peptide binding • peptide YY receptor activity • behavior • locomotory behavior • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • sensory perception of pain • feeding behavior • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • multicellular organism growth • regulation of multicellular organismal process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • heart development • heart morphogenesis • circulatory system development • anatomical structure morphogenesis • outflow tract morphogenesis • animal organ morphogenesis • signaling receptor binding • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide Y receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • transporter regulator activity • neuropeptide signaling pathway • nerve growth factor production • regulation of nerve growth factor production • neurotrophin production • regulation of neurotrophin production • cellular developmental process • central nervous system neuron development • cell development • nervous system development • generation of neurons • central nervous system neuron differentiation • neurogenesis • central nervous system development • neuron differentiation • cell differentiation • neuron development • response to light stimulus • photoperiodism • response to radiation • response to abiotic stimulus • short-day photoperiodism • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • cell adhesion • positive regulation of cell-substrate adhesion • epithelium development • digestive system development • intestinal epithelial cell differentiation • tube development • tissue development • digestive tract development • epithelial cell differentiation • columnar/cuboidal epithelial cell differentiation • regulation of amine metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • positive regulation of dopamine metabolic process • regulation of primary metabolic process • amine metabolic process • positive regulation of metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • positive regulation of amine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response to antigenic stimulus • response to stress • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • acute inflammatory response • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • regulation of acute inflammatory response • inflammatory response • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • positive regulation of cell population proliferation • regulation of cell population proliferation • head development • forebrain development • brain development • pallium development • cerebral cortex development • telencephalon development • monocyte activation • cell activation • myeloid leukocyte activation • leukocyte activation • synaptic signaling via neuropeptide • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of localization • cellular localization • regulated exocytosis • transport • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • localization • regulation of secretion by cell • secretion by cell • signal release • establishment of localization in cell • neurotransmitter secretion • regulation of transport • secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • export from cell • neurotransmitter transport • regulation of vesicle-mediated transport • establishment of localization • regulation of secretion • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • regulation of exocytosis • adult feeding behavior • adult behavior • plasma membrane bounded cell projection organization • cell projection organization • neuron projection development • cellular component organization • cellular component organization or biogenesis • negative regulation of blood pressure • perikaryon • neuronal cell body • axon • axon terminus • presynapse • distal axon • terminal bouton • neuron projection terminus • GABA-ergic synapse • Golgi apparatus • perinuclear region of cytoplasm
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25929
Sequence	>8K6O_nogp_Chain_R H L P L A M I F T L A L A Y G A V I I L G V S G N L A L I I I I L K Q K E M R N V T N I L I V N L S F S D L L V A I M C L P F T F V Y T L M D H W V F G E A M C K L N P F V Q C V S I T V S I F S L V L I A V E R H Q L I I N P R G W R P N N R H A Y V G I A V I W V L A V A S S L P F L I Y Q V M T D E P F Q N V T L D A Y K D K Y V C F D Q F P S D S H R L S Y T T L L L V L Q Y F G P L C F I F I C Y F K I Y I R L K R R N N M M D K M R D N K Y R S S E T K R I N I M L L S I V V A F A V C W L P L T I F N T V F D W N H Q I I A T C N H N L L F L L C H L T A M I S T C V N P I F Y G F L N K N F Q R D L Q F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published
	7VGX	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.2	2022-02-23	doi.org/10.1038/s41467-022-28510-6
	7VGX (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-		3.2	2022-02-23	doi.org/10.1038/s41467-022-28510-6
	5ZBH	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	BMS-193885	-	-	3	2018-04-25	doi.org/10.1038/s41586-018-0046-x
	5ZBQ	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	UR-MK-299	-	-	2.7	2018-04-25	doi.org/10.1038/s41586-018-0046-x
	7X9A	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.2	2022-05-18	doi.org/10.1126/sciadv.abm1232
	7X9A (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-		3.2	2022-05-18	doi.org/10.1126/sciadv.abm1232
	8K6M	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-	Gi2/β1/γ1	3.3	2024-07-31	doi.org/10.1002/mco2.565
	8K6M (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-		3.3	2024-07-31	doi.org/10.1002/mco2.565
	8K6O	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Pro-neuropeptide-Y	-	Gi2/β1/γ1	3.3	2024-07-31	doi.org/10.1002/mco2.565
	8K6O (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Pro-neuropeptide-Y	-		3.3	2024-07-31	doi.org/10.1002/mco2.565
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y12	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	Gi1/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y12 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-		3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y13	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y14	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	-	3.2	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-		2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-		3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009

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