psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:Y1	13.91	Yes	Yes	1	0	0
2	L:L:Y1	R:R:F199	6.19	Yes	Yes	1	0	3
3	L:L:Y1	R:R:D200	4.6	Yes	No	1	0	4
4	L:L:Y1	R:R:R208	11.32	Yes	Yes	1	0	4
5	L:L:P2	L:L:Y27	2.78	Yes	Yes	1	0	0
6	L:L:L30	L:L:P2	4.93	No	Yes	1	0	0
7	L:L:I31	L:L:P2	3.39	Yes	Yes	1	0	0
8	L:L:P2	R:R:F286	5.78	Yes	Yes	1	0	4
9	L:L:P2	R:R:H290	3.05	Yes	No	0	0	4
10	L:L:K4	L:L:Y27	4.78	No	Yes	0	0	0
11	L:L:P5	L:L:Y20	2.78	No	No	0	0	0
12	L:L:Y20	L:L:Y21	7.94	No	No	0	0	0
13	L:L:H26	L:L:S22	2.79	No	No	0	0	0
14	L:L:I28	L:L:L24	4.28	No	No	0	0	0
15	L:L:N29	L:L:R25	4.82	No	No	0	0	0
16	L:L:R25	R:R:D104	4.76	No	No	0	0	4
17	L:L:I31	L:L:Y27	13.3	Yes	Yes	1	0	0
18	L:L:Y27	R:R:P183	2.78	Yes	Yes	1	0	1
19	L:L:I28	R:R:F184	3.77	No	No	0	0	1
20	L:L:L30	R:R:F286	2.44	No	Yes	1	0	4
21	L:L:I31	R:R:V197	3.07	Yes	Yes	1	0	4
22	L:L:I31	R:R:F199	6.28	Yes	Yes	1	0	3
23	L:L:T32	R:R:Y100	6.24	No	No	0	0	6
24	L:L:R33	R:R:F282	4.28	Yes	Yes	1	0	5
25	L:L:R33	R:R:N283	3.62	Yes	No	0	0	5
26	L:L:R33	R:R:F286	13.9	Yes	Yes	1	0	4
27	L:L:R33	R:R:H298	7.9	Yes	Yes	1	0	3
28	L:L:R33	R:R:F302	19.24	Yes	Yes	1	0	5
29	L:L:?36	L:L:Q34	2.25	Yes	Yes	1	0	0
30	L:L:Q34	R:R:T97	4.25	Yes	Yes	1	0	6
31	L:L:Q34	R:R:Y100	10.15	Yes	No	0	0	6
32	L:L:Q34	R:R:N116	2.64	Yes	Yes	1	0	5
33	L:L:Q34	R:R:Q120	2.56	Yes	Yes	1	0	6
34	L:L:?36	L:L:R35	10.27	Yes	Yes	1	0	0
35	L:L:R35	R:R:F173	4.28	Yes	No	0	0	5
36	L:L:R35	R:R:R208	6.4	Yes	Yes	1	0	4
37	L:L:R35	R:R:T212	5.17	Yes	No	1	0	5
38	L:L:R35	R:R:N283	8.44	Yes	No	0	0	5
39	L:L:R35	R:R:D287	11.91	Yes	Yes	1	0	4
40	L:L:?36	R:R:C93	5.36	Yes	No	1	0	7
41	L:L:?36	R:R:T97	2.49	Yes	Yes	1	0	6
42	L:L:?36	R:R:Q120	11.25	Yes	Yes	1	0	6
43	L:L:?36	R:R:C121	6.71	Yes	No	0	0	4
44	L:L:?36	R:R:I124	4.82	Yes	Yes	1	0	7
45	L:L:?36	R:R:L215	2.34	Yes	No	0	0	5
46	L:L:?36	R:R:Q219	11.25	Yes	No	1	0	6
47	L:L:?36	R:R:H306	6.52	Yes	Yes	1	0	6
48	R:R:L35	R:R:P36	4.93	No	No	4	3	4
49	R:R:L35	R:R:M39	7.07	No	Yes	4	3	4
50	R:R:I40	R:R:L35	4.28	No	No	0	3	3
51	R:R:M39	R:R:P36	13.42	Yes	No	4	4	4
52	R:R:L303	R:R:L43	4.15	No	No	0	4	7
53	R:R:L94	R:R:Y47	2.34	Yes	Yes	0	7	7
54	R:R:F98	R:R:Y47	8.25	No	Yes	0	6	7
55	R:R:L303	R:R:Y47	5.86	No	Yes	0	4	7
56	R:R:L307	R:R:Y47	8.21	No	Yes	0	5	7
57	R:R:G48	R:R:I51	1.76	No	Yes	0	5	7
58	R:R:C314	R:R:V50	1.71	No	No	0	8	7
59	R:R:I51	R:R:L94	2.85	Yes	Yes	1	7	7
60	R:R:I51	R:R:P95	1.69	Yes	No	1	7	8
61	R:R:G54	R:R:L53	1.71	No	No	0	7	5
62	R:R:G54	R:R:N58	1.7	No	Yes	0	7	9
63	R:R:C314	R:R:G54	1.96	No	No	0	8	7
64	R:R:G57	R:R:S56	1.86	No	No	0	8	5
65	R:R:D86	R:R:N58	4.04	Yes	Yes	0	9	9
66	R:R:L87	R:R:N58	5.49	No	Yes	0	8	9
67	R:R:N58	R:R:P317	4.89	Yes	No	0	9	9
68	R:R:G321	R:R:L61	3.42	No	No	0	7	9
69	R:R:F327	R:R:L61	2.44	Yes	No	0	8	9
70	R:R:I62	R:R:L66	2.85	No	No	0	7	4
71	R:R:I62	R:R:S83	6.19	No	No	0	7	9
72	R:R:I64	R:R:R329	7.52	No	No	0	7	5
73	R:R:I65	R:R:L66	2.85	No	No	0	7	4
74	R:R:I65	R:R:N76	8.5	No	No	0	7	8
75	R:R:I65	R:R:V80	6.14	No	No	0	7	5
76	R:R:K67	R:R:R329	2.48	No	No	0	5	5
77	R:R:F327	R:R:Q68	3.51	Yes	No	0	8	5
78	R:R:E70	R:R:R72	8.14	No	No	0	5	6
79	R:R:N73	R:R:T75	5.85	No	No	0	8	7
80	R:R:N73	R:R:N76	13.62	No	No	6	8	8
81	R:R:L78	R:R:V74	2.98	No	No	0	7	6
82	R:R:A155	R:R:V74	1.7	No	No	0	7	6
83	R:R:I79	R:R:T75	3.04	No	No	0	8	7
84	R:R:E137	R:R:T75	8.47	No	No	0	8	7
85	R:R:I77	R:R:Y156	4.84	No	No	0	5	3
86	R:R:I134	R:R:L78	4.28	No	No	0	8	7
87	R:R:N81	R:R:S130	2.98	No	No	0	9	8
88	R:R:I159	R:R:N81	2.83	No	No	7	7	9
89	R:R:N81	R:R:W163	4.52	No	Yes	7	9	9
90	R:R:D86	R:R:L82	2.71	Yes	Yes	2	9	9
91	R:R:L82	R:R:S130	9.01	Yes	No	0	9	8
92	R:R:L131	R:R:L82	4.15	No	Yes	2	8	9
93	R:R:L82	R:R:N316	4.12	Yes	Yes	2	9	9
94	R:R:F84	R:R:W163	3.01	No	Yes	0	6	9
95	R:R:S85	R:R:V126	3.23	No	No	0	8	7
96	R:R:S127	R:R:S85	4.89	No	No	0	9	8
97	R:R:D86	R:R:S127	4.42	Yes	No	0	9	9
98	R:R:D86	R:R:N316	6.73	Yes	Yes	2	9	9
99	R:R:S123	R:R:V89	4.85	No	No	0	8	7
100	R:R:M92	R:R:V119	7.61	No	No	0	5	5
101	R:R:C93	R:R:Q120	12.21	No	Yes	1	7	6
102	R:R:L94	R:R:P95	3.28	Yes	No	1	7	8
103	R:R:H306	R:R:L94	2.57	Yes	Yes	1	6	7
104	R:R:L94	R:R:M310	2.83	Yes	No	1	7	7
105	R:R:F108	R:R:F96	8.57	Yes	No	0	7	6
106	R:R:F96	R:R:M112	2.49	No	No	0	6	6
107	R:R:F96	R:R:N116	7.25	No	Yes	0	6	5
108	R:R:F302	R:R:T97	2.59	Yes	Yes	1	5	6
109	R:R:H306	R:R:T97	9.58	Yes	Yes	1	6	6
110	R:R:F98	R:R:L102	2.44	No	No	0	6	4
111	R:R:M103	R:R:V99	3.04	No	No	0	3	4
112	R:R:F108	R:R:V99	6.55	Yes	No	0	7	4
113	R:R:W106	R:R:Y100	6.75	Yes	No	0	8	6
114	R:R:N299	R:R:T101	2.92	No	No	0	4	4
115	R:R:F302	R:R:T101	3.89	Yes	No	0	5	4
116	R:R:M103	R:R:V107	3.04	No	No	0	3	2
117	R:R:H105	R:R:V107	2.77	No	No	0	5	2
118	R:R:H105	R:R:K195	10.48	No	No	0	5	3
119	R:R:F108	R:R:W106	6.01	Yes	Yes	0	7	8
120	R:R:C113	R:R:W106	6.53	No	Yes	3	9	8
121	R:R:C198	R:R:W106	3.92	No	Yes	3	9	8
122	R:R:F108	R:R:V107	2.62	Yes	No	0	7	2
123	R:R:E110	R:R:M179	13.53	No	No	0	3	4
124	R:R:C113	R:R:Q177	7.63	No	Yes	3	9	5
125	R:R:C113	R:R:C198	7.28	No	No	3	9	9
126	R:R:K114	R:R:Q177	9.49	No	Yes	0	7	5
127	R:R:N116	R:R:P117	3.26	Yes	No	0	5	6
128	R:R:N116	R:R:Q120	7.92	Yes	Yes	1	5	6
129	R:R:P117	R:R:Q177	3.16	No	Yes	0	6	5
130	R:R:F118	R:R:S170	2.64	No	No	0	6	7
131	R:R:F118	R:R:L174	3.65	No	No	0	6	5
132	R:R:C121	R:R:T125	1.69	No	No	0	4	6
133	R:R:C121	R:R:S170	6.89	No	No	0	4	7
134	R:R:A166	R:R:V122	1.7	No	No	0	8	5
135	R:R:I124	R:R:Q219	4.12	Yes	No	1	7	6
136	R:R:I124	R:R:W276	3.52	Yes	Yes	1	7	8
137	R:R:F129	R:R:T125	5.19	Yes	No	0	7	6
138	R:R:A166	R:R:T125	3.36	No	No	0	8	6
139	R:R:V126	R:R:W163	9.81	No	Yes	0	7	9
140	R:R:A166	R:R:V126	1.7	No	No	0	8	7
141	R:R:I128	R:R:P223	3.39	No	Yes	1	7	9
142	R:R:F272	R:R:I128	3.77	Yes	No	1	9	7
143	R:R:F129	R:R:I162	8.79	Yes	No	0	7	7
144	R:R:F129	R:R:L165	2.44	Yes	No	0	7	5
145	R:R:L131	R:R:N316	4.12	No	Yes	2	8	9
146	R:R:P223	R:R:V132	3.53	Yes	No	0	9	7
147	R:R:F226	R:R:V132	2.62	No	No	0	6	7
148	R:R:I162	R:R:L133	8.56	No	No	0	7	7
149	R:R:I134	R:R:R138	3.76	No	No	2	8	9
150	R:R:I134	R:R:Y320	4.84	No	Yes	2	8	9
151	R:R:F226	R:R:V136	2.62	No	No	0	6	6
152	R:R:E137	R:R:L141	5.3	No	No	0	8	8
153	R:R:R138	R:R:Y231	2.06	No	Yes	0	9	9
154	R:R:R138	R:R:Y320	7.2	No	Yes	2	9	9
155	R:R:H139	R:R:I143	10.61	No	No	0	7	6
156	R:R:C230	R:R:H139	2.95	No	No	0	7	7
157	R:R:H139	R:R:K233	5.24	No	No	0	7	4
158	R:R:N144	R:R:Q140	10.56	No	No	0	6	4
159	R:R:Q140	R:R:W148	6.57	No	No	0	4	5
160	R:R:P150	R:R:Q140	3.16	No	No	0	6	4
161	R:R:L141	R:R:R149	7.29	No	No	0	8	5
162	R:R:L141	R:R:P150	3.28	No	No	0	8	6
163	R:R:I142	R:R:I234	10.3	No	No	0	8	8
164	R:R:I143	R:R:R237	2.51	No	No	0	6	5
165	R:R:H154	R:R:W148	7.41	No	No	0	4	5
166	R:R:H154	R:R:N151	2.55	No	No	0	4	7
167	R:R:N152	R:R:Y156	5.81	No	No	0	2	3
168	R:R:H154	R:R:R153	10.16	No	No	0	4	5
169	R:R:G158	R:R:V157	1.84	No	No	0	5	3
170	R:R:G158	R:R:V161	1.84	No	No	0	5	4
171	R:R:I159	R:R:W163	2.35	No	Yes	7	7	9
172	R:R:P172	R:R:Y211	16.69	No	Yes	0	8	6
173	R:R:D200	R:R:F173	2.39	No	No	0	4	5
174	R:R:F173	R:R:Y211	7.22	No	Yes	0	5	6
175	R:R:I175	R:R:Y176	4.84	No	No	0	4	5
176	R:R:F202	R:R:Y176	7.22	Yes	No	1	5	5
177	R:R:P203	R:R:Y176	11.13	Yes	No	1	5	5
178	R:R:C198	R:R:Q177	6.1	No	Yes	3	9	5
179	R:R:D181	R:R:V178	11.69	No	No	0	1	5
180	R:R:Q201	R:R:V178	5.73	No	No	0	3	5
181	R:R:M179	R:R:T180	4.52	No	No	8	4	3
182	R:R:M179	R:R:Y196	3.59	No	No	8	4	5
183	R:R:T180	R:R:Y196	13.73	No	No	8	3	5
184	R:R:D181	R:R:F199	8.36	No	Yes	0	1	3
185	R:R:F184	R:R:P183	8.67	No	Yes	1	1	1
186	R:R:P183	R:R:V197	5.3	Yes	Yes	1	1	4
187	R:R:F184	R:R:V197	2.62	No	Yes	1	1	4
188	R:R:F199	R:R:V197	3.93	Yes	Yes	1	3	4
189	R:R:D200	R:R:R208	10.72	No	Yes	1	4	4
190	R:R:F202	R:R:P203	4.33	Yes	Yes	1	5	5
191	R:R:F202	R:R:R208	12.83	Yes	Yes	1	5	4
192	R:R:F202	R:R:Y211	5.16	Yes	Yes	0	5	6
193	R:R:P203	R:R:S204	1.78	Yes	No	1	5	3
194	R:R:H207	R:R:P203	6.1	No	Yes	1	3	5
195	R:R:H207	R:R:S204	11.16	No	No	1	3	3
196	R:R:R208	R:R:T212	2.59	Yes	No	1	4	5
197	R:R:D287	R:R:R208	7.15	Yes	Yes	1	4	4
198	R:R:L209	R:R:W288	17.08	No	No	0	3	4
199	R:R:L215	R:R:Y211	4.69	No	Yes	0	5	6
200	R:R:D287	R:R:T212	8.67	Yes	No	1	4	5
201	R:R:L216	R:R:T280	2.95	No	No	0	6	8
202	R:R:L216	R:R:T284	2.95	No	No	0	6	6
203	R:R:F221	R:R:Y220	5.16	No	Yes	0	5	8
204	R:R:W276	R:R:Y220	1.93	Yes	Yes	0	8	8
205	R:R:L277	R:R:Y220	5.86	No	Yes	0	6	8
206	R:R:T280	R:R:Y220	3.75	No	Yes	0	8	8
207	R:R:G222	R:R:P223	4.06	No	Yes	0	5	9
208	R:R:F272	R:R:P223	2.89	Yes	Yes	1	9	9
209	R:R:F272	R:R:L224	3.65	Yes	No	0	9	6
210	R:R:C230	R:R:F226	4.19	No	No	0	7	6
211	R:R:I227	R:R:Y231	2.42	No	Yes	0	8	9
212	R:R:F228	R:R:I229	2.51	No	No	0	5	4
213	R:R:I234	R:R:Y231	2.42	No	Yes	0	8	9
214	R:R:L265	R:R:Y231	2.34	No	Yes	0	8	9
215	R:R:I268	R:R:Y231	2.42	Yes	Yes	0	7	9
216	R:R:V269	R:R:Y231	5.05	No	Yes	0	8	9
217	R:R:K239	R:R:Y235	2.39	No	No	0	4	5
218	R:R:N262	R:R:Y235	11.63	No	No	0	6	5
219	R:R:R237	R:R:R241	2.13	No	No	0	5	6
220	R:R:N242	R:R:R241	2.41	No	No	0	3	6
221	R:R:M245	R:R:R241	2.48	No	No	0	5	6
222	R:R:N242	R:R:R254	7.23	No	No	0	3	4
223	R:R:N242	R:R:T258	7.31	No	No	0	3	7
224	R:R:E257	R:R:R260	3.49	No	No	0	6	7
225	R:R:N262	R:R:T258	4.39	No	No	0	6	7
226	R:R:I261	R:R:R260	2.51	No	No	0	7	7
227	R:R:M264	R:R:R260	2.48	No	No	0	8	7
228	R:R:L323	R:R:M264	7.07	No	No	0	6	8
229	R:R:L266	R:R:V270	2.98	No	No	0	5	5
230	R:R:F319	R:R:S267	7.93	Yes	No	0	8	5
231	R:R:F319	R:R:I268	5.02	Yes	Yes	0	8	7
232	R:R:I268	R:R:Y320	3.63	Yes	Yes	0	7	9
233	R:R:F272	R:R:W276	3.01	Yes	Yes	1	9	8
234	R:R:C275	R:R:S312	3.44	No	No	0	8	9
235	R:R:L279	R:R:W276	2.28	No	Yes	1	7	8
236	R:R:A309	R:R:W276	2.59	No	Yes	1	8	8
237	R:R:S312	R:R:W276	3.71	No	Yes	0	9	8
238	R:R:I281	R:R:L277	2.85	No	No	0	5	6
239	R:R:C305	R:R:P278	3.77	No	No	0	6	9
240	R:R:P278	R:R:T308	3.5	No	No	0	9	7
241	R:R:L279	R:R:N283	2.75	No	No	0	7	5
242	R:R:A309	R:R:L279	3.15	No	No	1	8	7
243	R:R:F282	R:R:I293	7.54	Yes	No	1	5	3
244	R:R:F282	R:R:H298	5.66	Yes	Yes	1	5	3
245	R:R:F282	R:R:F302	8.57	Yes	Yes	1	5	5
246	R:R:T284	R:R:W288	2.43	No	No	0	6	4
247	R:R:I293	R:R:V285	4.61	No	No	0	3	4
248	R:R:D287	R:R:F286	4.78	Yes	Yes	1	4	4
249	R:R:N289	R:R:Q291	6.6	No	No	0	4	2
250	R:R:I292	R:R:N289	2.83	No	No	0	4	4
251	R:R:H290	R:R:Q291	2.47	No	No	0	4	2
252	R:R:H298	R:R:I293	3.98	Yes	No	1	3	3
253	R:R:L300	R:R:N297	4.12	No	No	0	2	3
254	R:R:H298	R:R:N299	2.55	Yes	No	0	3	4
255	R:R:F302	R:R:H298	2.26	Yes	Yes	1	5	3
256	R:R:H306	R:R:M310	9.19	Yes	No	1	6	7
257	R:R:I311	R:R:L307	4.28	No	No	0	6	5
258	R:R:N316	R:R:Y320	2.33	Yes	Yes	2	9	9
259	R:R:F319	R:R:I318	5.02	Yes	No	0	8	6
260	R:R:N324	R:R:N326	4.09	No	No	5	8	6
261	R:R:F327	R:R:N324	7.25	Yes	No	5	8	8
262	R:R:F327	R:R:N326	2.42	Yes	No	5	8	6
263	R:R:A90	R:R:T313	1.68	No	No	0	7	8
264	L:L:K4	L:L:P5	1.67	No	No	0	0	0
265	R:R:L171	R:R:P172	1.64	No	No	0	4	8
266	R:R:L277	R:R:P278	1.64	No	No	0	6	9
267	R:R:N144	R:R:P145	1.63	No	No	0	6	8
268	R:R:S206	R:R:S210	1.63	No	No	0	1	4
269	R:R:A155	R:R:I77	1.62	No	No	0	7	5
270	R:R:A135	R:R:I227	1.62	No	No	0	9	8
271	R:R:V119	R:R:V122	1.6	No	No	0	5	5
272	R:R:V122	R:R:V167	1.6	No	No	0	5	4
273	R:R:V270	R:R:V274	1.6	No	No	0	5	6
274	R:R:T313	R:R:V89	1.59	No	No	0	8	7
275	R:R:T213	R:R:V217	1.59	No	No	0	5	5
276	L:L:L30	R:R:A294	1.58	No	No	0	0	1
277	R:R:A273	R:R:L224	1.58	No	No	0	6	6
278	R:R:E182	R:R:P183	1.57	No	Yes	0	1	1
279	R:R:I52	R:R:S56	1.55	No	No	0	5	5
280	R:R:I124	R:R:S123	1.55	Yes	No	0	7	8
281	R:R:I51	R:R:V55	1.54	Yes	No	0	7	7
282	R:R:I311	R:R:V315	1.54	No	No	0	6	6
283	R:R:M39	R:R:T42	1.51	Yes	No	0	4	5
284	R:R:F108	R:R:G109	1.51	Yes	No	0	7	8
285	R:R:A111	R:R:E110	1.51	No	No	0	1	3
286	R:R:L61	R:R:S83	1.5	No	No	0	9	9
287	R:R:L88	R:R:S123	1.5	No	No	0	7	8
288	R:R:L215	R:R:S169	1.5	No	No	0	5	5
289	R:R:L59	R:R:V55	1.49	No	No	0	4	7
290	R:R:N58	R:R:S83	1.49	Yes	No	0	9	9
291	L:L:H26	R:R:C296	1.47	No	No	0	0	2
292	R:R:L43	R:R:T42	1.47	No	No	0	7	5
293	R:R:I91	R:R:M92	1.46	No	No	0	5	5
294	R:R:I268	R:R:M264	1.46	Yes	No	0	7	8
295	R:R:N297	R:R:T295	1.46	No	No	0	3	1
296	R:R:P145	R:R:R146	1.44	No	No	0	8	6
297	R:R:I52	R:R:L53	1.43	No	No	0	5	5
298	R:R:I63	R:R:L59	1.43	No	No	0	3	4
299	R:R:I261	R:R:L238	1.43	No	No	0	7	8
300	R:R:L300	R:R:M39	1.41	No	Yes	0	2	4
301	R:R:L66	R:R:M71	1.41	No	No	0	4	7
302	R:R:K114	R:R:L115	1.41	No	No	0	7	5
303	R:R:A44	R:R:F98	1.39	No	No	0	5	6
304	R:R:A271	R:R:F319	1.39	No	Yes	0	7	8
305	R:R:I64	R:R:Q68	1.37	No	No	0	7	5
306	R:R:E70	R:R:N73	1.31	No	No	6	5	8
307	R:R:E70	R:R:N76	1.31	No	No	6	5	8
308	R:R:F41	R:R:L45	1.22	No	No	0	6	5
309	R:R:F129	R:R:L218	1.22	Yes	No	0	7	5
310	R:R:F282	R:R:L301	1.22	Yes	No	0	5	6
311	R:R:T213	R:R:W288	1.21	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	9.005	4	1	0
2	L:L:P2	5.64	6	1	0
3	L:L:Y27	5.91	4	1	0
4	L:L:I31	6.51	4	1	0
5	L:L:R33	9.788	5	1	0
6	L:L:Q34	4.37	5	1	0
7	L:L:R35	7.745	6	1	0
8	L:L:?36	6.326	10	1	0
9	R:R:M39	5.8525	4	4	4
10	R:R:Y47	6.165	4	0	7
11	R:R:I51	1.96	4	1	7
12	R:R:N58	3.522	5	0	9
13	R:R:L82	4.9975	4	2	9
14	R:R:D86	4.475	4	2	9
15	R:R:L94	2.774	5	1	7
16	R:R:T97	4.7275	4	1	6
17	R:R:W106	5.8025	4	3	8
18	R:R:F108	5.052	5	0	7
19	R:R:N116	5.2675	4	1	5
20	R:R:Q120	8.485	4	1	6
21	R:R:I124	3.5025	4	1	7
22	R:R:F129	4.41	4	0	7
23	R:R:W163	4.9225	4	7	9
24	R:R:Q177	6.595	4	3	5
25	R:R:P183	4.58	4	1	1
26	R:R:V197	3.73	4	1	4
27	R:R:F199	6.19	4	1	3
28	R:R:F202	7.385	4	1	5
29	R:R:P203	5.835	4	1	5
30	R:R:R208	8.50167	6	1	4
31	R:R:Y211	8.44	4	0	6
32	R:R:Y220	4.175	4	0	8
33	R:R:P223	3.4675	4	1	9
34	R:R:Y231	2.785	6	0	9
35	R:R:I268	3.1325	4	0	7
36	R:R:F272	3.33	4	1	9
37	R:R:W276	2.84	6	1	8
38	R:R:F282	5.454	5	1	5
39	R:R:F286	6.725	4	1	4
40	R:R:D287	8.1275	4	1	4
41	R:R:H298	4.47	5	1	3
42	R:R:F302	7.31	5	1	5
43	R:R:H306	6.965	4	1	6
44	R:R:N316	4.325	4	2	9
45	R:R:F319	4.84	4	0	8
46	R:R:Y320	4.5	4	2	9
47	R:R:F327	3.905	4	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:Y1	13.3259	13.91	Yes	Yes	1	0	0
2	L:L:Y1	R:R:F199	14.058	6.19	Yes	Yes	1	0	3
3	L:L:Y1	R:R:R208	26.8974	11.32	Yes	Yes	1	0	4
4	L:L:P2	L:L:Y27	17.7416	2.78	Yes	Yes	1	0	0
5	L:L:R35	R:R:R208	35.4972	6.4	Yes	Yes	1	0	4
6	L:L:?36	L:L:R35	53.072	10.27	Yes	Yes	1	0	0
7	L:L:?36	L:L:Q34	33.0692	2.25	Yes	Yes	1	0	0
8	L:L:Q34	R:R:Y100	18.3486	10.15	Yes	No	0	0	6
9	L:L:P2	R:R:F286	20.3688	5.78	Yes	Yes	1	0	4
10	L:L:R33	R:R:F286	10.5875	13.9	Yes	Yes	1	0	4
11	R:R:F302	R:R:T97	14.3546	2.59	Yes	Yes	1	5	6
12	L:L:R35	R:R:D287	15.1979	11.91	Yes	Yes	1	0	4
13	R:R:D287	R:R:F286	14.8411	4.78	Yes	Yes	1	4	4
14	L:L:Q34	R:R:N116	20.8553	2.64	Yes	Yes	1	0	5
15	L:L:?36	R:R:Q120	18.3857	11.25	Yes	Yes	1	0	6
16	R:R:N116	R:R:Q120	17.32	7.92	Yes	Yes	1	5	6
17	L:L:?36	R:R:C121	100	6.71	Yes	No	0	0	4
18	L:L:?36	R:R:I124	47.8454	4.82	Yes	Yes	1	0	7
19	R:R:L215	R:R:Y211	10.3003	4.69	No	Yes	0	5	6
20	L:L:?36	R:R:L215	12.4131	2.34	Yes	No	0	0	5
21	L:L:?36	R:R:H306	32.5225	6.52	Yes	Yes	1	0	6
22	R:R:H306	R:R:L94	36.5814	2.57	Yes	Yes	1	6	7
23	R:R:L94	R:R:Y47	26.5406	2.34	Yes	Yes	0	7	7
24	R:R:L303	R:R:Y47	15.9346	5.86	No	Yes	0	4	7
25	R:R:L303	R:R:L43	14.3777	4.15	No	No	0	4	7
26	R:R:L43	R:R:T42	12.8162	1.47	No	No	0	7	5
27	R:R:M39	R:R:T42	11.2455	1.51	Yes	No	0	4	5
28	R:R:C121	R:R:T125	98.1837	1.69	No	No	0	4	6
29	R:R:A166	R:R:T125	95.1812	3.36	No	No	0	8	6
30	R:R:A166	R:R:V126	91.8451	1.7	No	No	0	8	7
31	R:R:S85	R:R:V126	84.6029	3.23	No	No	0	8	7
32	R:R:S127	R:R:S85	83.9542	4.89	No	No	0	9	8
33	R:R:D86	R:R:S127	83.3055	4.42	Yes	No	0	9	9
34	R:R:D86	R:R:N58	52.7801	4.04	Yes	Yes	0	9	9
35	R:R:N58	R:R:S83	41.9377	1.49	Yes	No	0	9	9
36	R:R:L61	R:R:S83	12.2509	1.5	No	No	0	9	9
37	R:R:I62	R:R:S83	30.4652	6.19	No	No	0	7	9
38	R:R:I62	R:R:L66	29.2373	2.85	No	No	0	7	4
39	R:R:I65	R:R:L66	26.7538	2.85	No	No	0	7	4
40	R:R:I65	R:R:N76	24.2332	8.5	No	No	0	7	8
41	R:R:N73	R:R:N76	20.2437	13.62	No	No	6	8	8
42	R:R:N73	R:R:T75	19.0807	5.85	No	No	0	8	7
43	R:R:D86	R:R:N316	43.337	6.73	Yes	Yes	2	9	9
44	R:R:N316	R:R:Y320	42.1416	2.33	Yes	Yes	2	9	9
45	R:R:E137	R:R:T75	16.4489	8.47	No	No	0	8	7
46	R:R:W106	R:R:Y100	15.8141	6.75	Yes	No	0	8	6
47	R:R:F108	R:R:W106	11.7969	6.01	Yes	Yes	0	7	8
48	R:R:F96	R:R:N116	25.7344	7.25	No	Yes	0	6	5
49	R:R:F108	R:R:F96	20.6098	8.57	Yes	No	0	7	6
50	R:R:F108	R:R:V107	16.3377	2.62	Yes	No	0	7	2
51	R:R:N116	R:R:P117	10.2261	3.26	Yes	No	0	5	6
52	R:R:L279	R:R:N283	11.542	2.75	No	No	0	7	5
53	R:R:L279	R:R:W276	11.1945	2.28	No	Yes	1	7	8
54	R:R:F272	R:R:W276	30.0158	3.01	Yes	Yes	1	9	8
55	R:R:F272	R:R:P223	24.7058	2.89	Yes	Yes	1	9	9
56	R:R:P223	R:R:V132	22.1203	3.53	Yes	No	0	9	7
57	R:R:F226	R:R:V132	20.7719	2.62	No	No	0	6	7
58	R:R:E137	R:R:L141	15.2349	5.3	No	No	0	8	8
59	R:R:I268	R:R:Y320	22.7829	3.63	Yes	Yes	0	7	9
60	R:R:C230	R:R:F226	18.0474	4.19	No	No	0	7	6
61	R:R:C230	R:R:H139	16.6713	2.95	No	No	0	7	7
62	R:R:H139	R:R:I143	13.8912	10.61	No	No	0	7	6
63	R:R:L141	R:R:P150	12.5429	3.28	No	No	0	8	6
64	R:R:P150	R:R:Q140	11.1806	3.16	No	No	0	6	4
65	R:R:W276	R:R:Y220	19.975	1.93	Yes	Yes	0	8	8
66	R:R:T280	R:R:Y220	10.2122	3.75	No	Yes	0	8	8
67	R:R:I143	R:R:R237	12.4734	2.51	No	No	0	6	5
68	R:R:R237	R:R:R241	11.1899	2.13	No	No	0	5	6
69	L:L:P2	R:R:H290	10.0222	3.05	Yes	No	0	0	4
70	R:R:I124	R:R:W276	41.9748	3.52	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:F199	6.19	1	Yes	Yes	0	3	0	1
L:L:Y1	R:R:D200	4.6	1	Yes	No	0	4	0	1
L:L:Y1	R:R:R208	11.32	1	Yes	Yes	0	4	0	1
L:L:P2	R:R:F286	5.78	1	Yes	Yes	0	4	0	1
L:L:P2	R:R:H290	3.05	1	Yes	No	0	4	0	1
L:L:R25	R:R:D104	4.76	0	No	No	0	4	0	1
L:L:Y27	R:R:P183	2.78	1	Yes	Yes	0	1	0	1
L:L:I28	R:R:F184	3.77	0	No	No	0	1	0	1
L:L:L30	R:R:F286	2.44	1	No	Yes	0	4	0	1
L:L:I31	R:R:V197	3.07	1	Yes	Yes	0	4	0	1
L:L:I31	R:R:F199	6.28	1	Yes	Yes	0	3	0	1
L:L:T32	R:R:Y100	6.24	0	No	No	0	6	0	1
L:L:R33	R:R:F282	4.28	1	Yes	Yes	0	5	0	1
L:L:R33	R:R:N283	3.62	1	Yes	No	0	5	0	1
L:L:R33	R:R:F286	13.9	1	Yes	Yes	0	4	0	1
L:L:R33	R:R:H298	7.9	1	Yes	Yes	0	3	0	1
L:L:R33	R:R:F302	19.24	1	Yes	Yes	0	5	0	1
L:L:Q34	R:R:T97	4.25	1	Yes	Yes	0	6	0	1
L:L:Q34	R:R:Y100	10.15	1	Yes	No	0	6	0	1
L:L:Q34	R:R:N116	2.64	1	Yes	Yes	0	5	0	1
L:L:Q34	R:R:Q120	2.56	1	Yes	Yes	0	6	0	1
L:L:R35	R:R:F173	4.28	1	Yes	No	0	5	0	1
L:L:R35	R:R:R208	6.4	1	Yes	Yes	0	4	0	1
L:L:R35	R:R:T212	5.17	1	Yes	No	0	5	0	1
L:L:R35	R:R:N283	8.44	1	Yes	No	0	5	0	1
L:L:R35	R:R:D287	11.91	1	Yes	Yes	0	4	0	1
L:L:?36	R:R:C93	5.36	1	Yes	No	0	7	0	1
L:L:?36	R:R:T97	2.49	1	Yes	Yes	0	6	0	1
L:L:?36	R:R:Q120	11.25	1	Yes	Yes	0	6	0	1
L:L:?36	R:R:C121	6.71	1	Yes	No	0	4	0	1
L:L:?36	R:R:I124	4.82	1	Yes	Yes	0	7	0	1
L:L:?36	R:R:L215	2.34	1	Yes	No	0	5	0	1
L:L:?36	R:R:Q219	11.25	1	Yes	No	0	6	0	1
L:L:?36	R:R:H306	6.52	1	Yes	Yes	0	6	0	1
R:R:C93	R:R:Q120	12.21	1	No	Yes	7	6	1	1
R:R:H306	R:R:L94	2.57	1	Yes	Yes	6	7	1	2
R:R:L94	R:R:M310	2.83	1	Yes	No	7	7	2	2
R:R:F96	R:R:N116	7.25	0	No	Yes	6	5	2	1
R:R:F302	R:R:T97	2.59	1	Yes	Yes	5	6	1	1
R:R:H306	R:R:T97	9.58	1	Yes	Yes	6	6	1	1
R:R:W106	R:R:Y100	6.75	3	Yes	No	8	6	2	1
R:R:N299	R:R:T101	2.92	0	No	No	4	4	2	2
R:R:F302	R:R:T101	3.89	1	Yes	No	5	4	1	2
R:R:N116	R:R:P117	3.26	1	Yes	No	5	6	1	2
R:R:N116	R:R:Q120	7.92	1	Yes	Yes	5	6	1	1
R:R:C121	R:R:T125	1.69	0	No	No	4	6	1	2
R:R:C121	R:R:S170	6.89	0	No	No	4	7	1	2
R:R:I124	R:R:Q219	4.12	1	Yes	No	7	6	1	1
R:R:I124	R:R:W276	3.52	1	Yes	Yes	7	8	1	2
R:R:D200	R:R:F173	2.39	1	No	No	4	5	1	1
R:R:F173	R:R:Y211	7.22	0	No	Yes	5	6	1	2
R:R:D181	R:R:F199	8.36	0	No	Yes	1	3	2	1
R:R:F184	R:R:P183	8.67	1	No	Yes	1	1	1	1
R:R:P183	R:R:V197	5.3	1	Yes	Yes	1	4	1	1
R:R:F184	R:R:V197	2.62	1	No	Yes	1	4	1	1
R:R:F199	R:R:V197	3.93	1	Yes	Yes	3	4	1	1
R:R:D200	R:R:R208	10.72	1	No	Yes	4	4	1	1
R:R:F202	R:R:R208	12.83	1	Yes	Yes	5	4	2	1
R:R:F202	R:R:Y211	5.16	1	Yes	Yes	5	6	2	2
R:R:R208	R:R:T212	2.59	1	Yes	No	4	5	1	1
R:R:D287	R:R:R208	7.15	1	Yes	Yes	4	4	1	1
R:R:L215	R:R:Y211	4.69	0	No	Yes	5	6	1	2
R:R:D287	R:R:T212	8.67	1	Yes	No	4	5	1	1
R:R:L279	R:R:W276	2.28	1	No	Yes	7	8	2	2
R:R:L279	R:R:N283	2.75	1	No	No	7	5	2	1
R:R:F282	R:R:I293	7.54	1	Yes	No	5	3	1	2
R:R:F282	R:R:H298	5.66	1	Yes	Yes	5	3	1	1
R:R:F282	R:R:F302	8.57	1	Yes	Yes	5	5	1	1
R:R:D287	R:R:F286	4.78	1	Yes	Yes	4	4	1	1
R:R:H290	R:R:Q291	2.47	0	No	No	4	2	1	2
R:R:H298	R:R:I293	3.98	1	Yes	No	3	3	1	2
R:R:H298	R:R:N299	2.55	1	Yes	No	3	4	1	2
R:R:F302	R:R:H298	2.26	1	Yes	Yes	5	3	1	1
R:R:H306	R:R:M310	9.19	1	Yes	No	6	7	1	2
L:L:L30	R:R:A294	1.58	1	No	No	0	1	0	1
R:R:E182	R:R:P183	1.57	0	No	Yes	1	1	2	1
R:R:I124	R:R:S123	1.55	1	Yes	No	7	8	1	2
R:R:L215	R:R:S169	1.5	0	No	No	5	5	1	2
L:L:H26	R:R:C296	1.47	0	No	No	0	2	0	1
R:R:F282	R:R:L301	1.22	1	Yes	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VGX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.69
Number of Linked Nodes	271
Number of Links	311
Number of Hubs	47
Number of Links mediated by Hubs	158
Number of Communities	8
Number of Nodes involved in Communities	70
Number of Links involved in Communities	100

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	46705
Length Of Smallest Path	3
Average Path Length	13.5215
Length of Longest Path	39
Minimum Path Strength	1.4
Average Path Strength	4.76069
Maximum Path Strength	13.2075
Minimum Path Correlation	0.7
Average Path Correlation	0.923611
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	51.3842
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.151
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• behavior • multicellular organismal process • locomotory behavior • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • sensory perception • nervous system process • sensory perception of pain • feeding behavior • regulation of multicellular organism growth • developmental process • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • multicellular organism growth • regulation of multicellular organismal process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • monosaccharide metabolic process • carbohydrate metabolic process • hexose metabolic process • small molecule metabolic process • metabolic process • primary metabolic process • glucose metabolic process • heart development • heart morphogenesis • animal organ development • circulatory system development • multicellular organism development • anatomical structure morphogenesis • anatomical structure development • outflow tract morphogenesis • animal organ morphogenesis • system development • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide Y receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • transporter regulator activity • neuropeptide signaling pathway • nerve growth factor production • regulation of nerve growth factor production • neurotrophin production • regulation of neurotrophin production • cellular developmental process • central nervous system neuron development • cell development • nervous system development • generation of neurons • central nervous system neuron differentiation • neurogenesis • central nervous system development • neuron differentiation • cell differentiation • neuron development • response to light stimulus • photoperiodism • response to radiation • response to abiotic stimulus • short-day photoperiodism • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • cell adhesion • positive regulation of cell-substrate adhesion • epithelium development • digestive system development • intestinal epithelial cell differentiation • tube development • tissue development • digestive tract development • epithelial cell differentiation • columnar/cuboidal epithelial cell differentiation • regulation of amine metabolic process • dopamine metabolic process • catechol-containing compound metabolic process • positive regulation of dopamine metabolic process • regulation of primary metabolic process • amine metabolic process • positive regulation of metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • regulation of catecholamine metabolic process • positive regulation of amine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response to antigenic stimulus • response to stress • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • acute inflammatory response • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • regulation of acute inflammatory response • inflammatory response • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • response to chemical • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • head development • forebrain development • brain development • pallium development • cerebral cortex development • telencephalon development • monocyte activation • cell activation • myeloid leukocyte activation • leukocyte activation • synaptic signaling • cell-cell signaling • synaptic signaling via neuropeptide • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of localization • cellular localization • regulated exocytosis • transport • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • localization • regulation of secretion by cell • secretion by cell • signal release • establishment of localization in cell • neurotransmitter secretion • regulation of transport • secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • export from cell • neurotransmitter transport • regulation of vesicle-mediated transport • establishment of localization • regulation of secretion • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • regulation of exocytosis • adult feeding behavior • adult behavior • plasma membrane bounded cell projection organization • cell projection organization • neuron projection development • cellular component organization • cellular component organization or biogenesis • negative regulation of blood pressure • somatodendritic compartment • cell body • perikaryon • neuronal cell body • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • axon • synapse • axon terminus • presynapse • distal axon • terminal bouton • cell junction • neuron projection terminus • GABA-ergic synapse • Golgi apparatus • extracellular region • perinuclear region of cytoplasm • extracellular space • D2 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • cilium • ciliary basal body • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYC
PDB Residues	L:L:?36
Environment Details	Open EMBL-EBI Page
Code	TYC
Name	L-tyrosinamide
Synonyms	L-tyrosinamide (2S)-2-amino-3-(4-hydroxyphenyl)propanamide L-Tyrosine amide Tyrosinamide Tyrosine amide
Identifier
Formula	C9 H12 N2 O2
Molecular Weight	180.204
SMILES
PubChem	151243
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25929
Sequence	>7VGX_nogp_Chain_R L P L A M I F T L A L A Y G A V I I L G V S G N L A L I I I I L K Q K E M R N V T N I L I V N L S F S D L L V A I M C L P F T F V Y T L M D H W V F G E A M C K L N P F V Q C V S I T V S I F S L V L I A V E R H Q L I I N P R G W R P N N R H A Y V G I A V I W V L A V A S S L P F L I Y Q V M T D E P F D K Y V C F D Q F P S D S H R L S Y T T L L L V L Q Y F G P L C F I F I C Y F K I Y I R L K R R N N M M D Y R S S E T K R I N I M L L S I V V A F A V C W L P L T I F N T V F D W N H Q I I A T C N H N L L F L L C H L T A M I S T C V N P I F Y G F L N K N F Q R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9AUC	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-	Gs/β1/γ2; RAMP1	2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	9AUC (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin gene-related peptide-1	-		2.4	2024-04-24	doi.org/10.1021/acs.biochem.4c00114
	7TYF	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP1	2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYF (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Amylin	-		2.2	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP1	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	9BLW	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-	Gs/β1/γ2; RAMP1	3.2	2025-04-16	To be published
	9BLW (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide backbone (non-acylated)	-		3.2	2025-04-16	To be published
	9BP3	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP1	2.2	2025-04-23	To be published
	9BP3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY1)	Homo sapiens	Cagrilintide	-		2.2	2025-04-23	To be published
	7VGX	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.2	2022-02-23	doi.org/10.1038/s41467-022-28510-6
	7VGX (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-		3.2	2022-02-23	doi.org/10.1038/s41467-022-28510-6
	5ZBH	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	BMS-193885	-	-	3	2018-04-25	doi.org/10.1038/s41586-018-0046-x
	5ZBQ	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	UR-MK-299	-	-	2.7	2018-04-25	doi.org/10.1038/s41586-018-0046-x
	7X9A	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.2	2022-05-18	doi.org/10.1126/sciadv.abm1232
	7X9A (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-		3.2	2022-05-18	doi.org/10.1126/sciadv.abm1232
	8K6M	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-	Gi2/β1/γ1	3.3	2024-07-31	doi.org/10.1002/mco2.565
	8K6M (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Neuropeptide-Y	-		3.3	2024-07-31	doi.org/10.1002/mco2.565
	8K6O	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Pro-neuropeptide-Y	-	Gi2/β1/γ1	3.3	2024-07-31	doi.org/10.1002/mco2.565
	8K6O (No Gprot)	A	Peptide	Neuropeptide Y	Y₁	Homo sapiens	Pro-neuropeptide-Y	-		3.3	2024-07-31	doi.org/10.1002/mco2.565
	7Y1F	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-	Gi1/β1/γ2	3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y1F (No Gprot)	A	Peptide	Opioid	κ	Homo sapiens	Dynorphin	-		3.3	2023-05-24	doi.org/10.1093/procel/pwac033
	7Y12	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	Gi1/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y12 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-		3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y13	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	-	3.1	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y14	A	Orphan	Orphan	MRGPRD	Homo sapiens	β-Alanine	-	-	3.2	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-	Gi1/β1/γ2	2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	7Y15 (No Gprot)	A	Orphan	Orphan	MRGPRD	Homo sapiens	-	-		2.9	2022-07-20	doi.org/10.1038/s42003-022-03668-3
	8KGG	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-	chim(NtGi2-G13)/β1/γ2	3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	8KGG (No Gprot)	A	Nucleotide	P2Y	P2Y10	Homo sapiens	LPS	-		3.06	2024-07-31	doi.org/10.1016/j.chembiol.2024.08.005
	6D27	A	Lipid	Prostanoid	DP₂	Homo sapiens	CAY10471	-	-	2.74	2018-10-03	doi.org/10.1016/j.molcel.2018.08.009

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