psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:Y1	5.56	No	No	0	0	0
2	L:L:Y1	R:R:E188	5.61	No	Yes	1	0	4
3	L:L:Y1	R:R:K206	5.97	No	No	1	0	3
4	L:L:P2	L:L:Y27	9.74	No	No	0	0	0
5	L:L:I31	L:L:P2	6.77	Yes	No	0	0	0
6	L:L:K4	L:L:P5	3.35	Yes	Yes	1	0	0
7	L:L:K4	L:L:Y27	11.94	Yes	No	1	0	0
8	L:L:K4	R:R:I192	4.36	Yes	No	1	0	2
9	L:L:K4	R:R:I194	4.36	Yes	No	1	0	1
10	L:L:P5	L:L:Y20	6.95	Yes	Yes	1	0	0
11	L:L:L24	L:L:P5	4.93	Yes	Yes	1	0	0
12	L:L:M17	L:L:Y20	3.59	No	Yes	1	0	0
13	L:L:M17	L:L:Y21	3.59	No	No	1	0	0
14	L:L:Y20	L:L:Y21	2.98	Yes	No	1	0	0
15	L:L:L24	L:L:Y20	3.52	Yes	Yes	1	0	0
16	L:L:Y21	R:R:L40	5.86	No	No	0	0	7
17	L:L:I28	L:L:L24	4.28	No	Yes	0	0	0
18	L:L:R25	R:R:S43	3.95	No	No	0	0	5
19	L:L:R25	R:R:L300	13.36	No	No	0	0	1
20	L:L:H26	R:R:V297	4.15	No	No	0	0	6
21	L:L:Y27	R:R:I192	9.67	No	No	1	0	2
22	L:L:N29	R:R:V297	4.43	No	No	2	0	6
23	L:L:N29	R:R:Y303	3.49	No	Yes	2	0	4
24	L:L:I31	L:L:T32	3.04	Yes	No	0	0	0
25	L:L:I31	R:R:I192	4.42	Yes	No	1	0	2
26	L:L:I31	R:R:A202	3.25	Yes	No	1	0	4
27	L:L:I31	R:R:T204	4.56	Yes	No	1	0	4
28	L:L:T32	R:R:Y110	11.24	No	No	0	0	5
29	L:L:R33	L:L:R35	8.53	Yes	Yes	2	0	0
30	L:L:R33	R:R:E205	3.49	Yes	No	0	0	4
31	L:L:R33	R:R:Q288	3.5	Yes	No	2	0	5
32	L:L:R33	R:R:V291	10.46	Yes	No	2	0	4
33	L:L:R33	R:R:D292	11.91	Yes	No	2	0	5
34	L:L:Q34	R:R:T107	7.09	Yes	No	0	0	6
35	L:L:Q34	R:R:Y110	12.4	Yes	No	0	0	5
36	L:L:Q34	R:R:T111	4.25	Yes	No	0	0	4
37	L:L:Q34	R:R:F307	4.68	Yes	No	0	0	4
38	L:L:R35	L:L:Y36	3.09	Yes	Yes	0	0	0
39	L:L:R35	R:R:Y219	11.32	Yes	Yes	0	0	6
40	L:L:R35	R:R:Q288	5.84	Yes	No	2	0	5
41	L:L:R35	R:R:D292	7.15	Yes	No	2	0	5
42	L:L:Y36	R:R:Q130	3.38	Yes	No	0	0	6
43	L:L:Y36	R:R:S223	3.82	Yes	No	0	0	5
44	L:L:Y36	R:R:H285	6.53	Yes	No	0	0	7
45	R:R:E39	R:R:I41	15.03	No	No	0	3	3
46	R:R:K301	R:R:T44	3	No	No	0	3	4
47	R:R:K304	R:R:K45	4.31	No	No	0	4	3
48	R:R:E48	R:R:L46	9.28	No	No	0	2	2
49	R:R:I47	R:R:V51	3.07	No	No	0	2	6
50	R:R:I54	R:R:Q50	5.49	No	No	0	6	4
51	R:R:L112	R:R:Q50	3.99	No	No	0	4	4
52	R:R:L55	R:R:V51	2.98	No	No	0	6	6
53	R:R:L53	R:R:T308	7.37	No	No	0	5	3
54	R:R:L108	R:R:Y57	8.21	No	Yes	0	6	7
55	R:R:T308	R:R:Y57	6.24	No	Yes	0	3	7
56	R:R:H311	R:R:Y57	4.36	Yes	Yes	0	5	7
57	R:R:I312	R:R:Y57	7.25	No	Yes	0	5	7
58	R:R:I312	R:R:I60	7.36	No	No	0	5	7
59	R:R:F319	R:R:I60	6.28	No	No	0	7	7
60	R:R:I61	R:R:N100	9.91	No	Yes	0	6	6
61	R:R:F319	R:R:L63	3.65	No	No	0	7	6
62	R:R:L97	R:R:V65	2.98	No	No	0	7	6
63	R:R:N100	R:R:V65	4.43	Yes	No	0	6	6
64	R:R:A93	R:R:N68	3.13	No	Yes	0	9	9
65	R:R:D96	R:R:N68	6.73	No	Yes	0	9	9
66	R:R:L97	R:R:N68	8.24	No	Yes	0	7	9
67	R:R:N68	R:R:P322	6.52	Yes	No	0	9	9
68	R:R:F336	R:R:L70	7.31	No	No	0	6	7
69	R:R:A93	R:R:V71	3.39	No	No	0	9	9
70	R:R:A93	R:R:I72	3.25	No	No	0	9	7
71	R:R:I72	R:R:V94	3.07	No	No	0	7	6
72	R:R:H73	R:R:K77	3.93	No	No	0	4	5
73	R:R:F336	R:R:V74	9.18	No	No	0	6	7
74	R:R:A90	R:R:V75	5.09	No	No	0	6	7
75	R:R:V75	R:R:Y332	5.05	No	Yes	0	7	8
76	R:R:F78	R:R:K77	12.41	Yes	No	0	5	5
77	R:R:A335	R:R:F78	4.16	No	Yes	0	6	5
78	R:R:K79	R:R:R82	9.9	No	No	0	6	6
79	R:R:M81	R:R:N86	9.82	No	No	7	8	8
80	R:R:M81	R:R:Y332	5.99	No	Yes	7	8	8
81	R:R:F87	R:R:R82	7.48	No	No	0	5	6
82	R:R:N86	R:R:T83	8.77	No	No	0	8	7
83	R:R:F88	R:R:V84	5.24	Yes	No	3	7	6
84	R:R:S165	R:R:V84	6.46	No	No	3	7	6
85	R:R:D147	R:R:T85	7.23	No	No	0	8	8
86	R:R:N86	R:R:Y332	10.47	No	Yes	7	8	8
87	R:R:F88	R:R:V143	6.55	Yes	No	0	7	7
88	R:R:F88	R:R:I144	5.02	Yes	Yes	3	7	9
89	R:R:D147	R:R:F88	4.78	No	Yes	0	8	7
90	R:R:F88	R:R:S165	5.28	Yes	No	3	7	7
91	R:R:I89	R:R:Y332	13.3	No	Yes	0	8	8
92	R:R:N91	R:R:T140	13.16	No	No	0	9	8
93	R:R:N91	R:R:W173	5.65	No	Yes	0	9	9
94	R:R:L92	R:R:T140	7.37	No	No	0	9	8
95	R:R:L141	R:R:L92	5.54	No	No	0	8	9
96	R:R:L92	R:R:N321	4.12	No	No	0	9	9
97	R:R:A95	R:R:V136	3.39	No	No	0	8	7
98	R:R:D96	R:R:S137	4.42	No	No	0	9	9
99	R:R:D96	R:R:N321	6.73	No	No	0	9	9
100	R:R:M315	R:R:V99	3.04	Yes	No	0	7	7
101	R:R:L104	R:R:N100	4.12	No	Yes	0	7	6
102	R:R:N100	R:R:T318	4.39	Yes	No	0	6	9
103	R:R:C103	R:R:H311	4.42	No	Yes	6	6	5
104	R:R:C103	R:R:M315	4.86	No	Yes	6	6	7
105	R:R:L104	R:R:P105	3.28	No	No	0	7	8
106	R:R:L104	R:R:M315	4.24	No	Yes	0	7	7
107	R:R:F106	R:R:V126	10.49	No	No	0	5	5
108	R:R:H311	R:R:T107	6.85	Yes	No	0	5	6
109	R:R:L108	R:R:L112	6.92	No	No	0	6	4
110	R:R:W116	R:R:Y110	9.65	Yes	No	0	8	5
111	R:R:K304	R:R:T111	3	No	No	0	4	4
112	R:R:E115	R:R:E199	3.81	No	No	0	5	4
113	R:R:E115	R:R:I200	8.2	No	No	0	5	3
114	R:R:M118	R:R:W116	13.96	No	Yes	0	7	8
115	R:R:C123	R:R:W116	6.53	No	Yes	8	9	8
116	R:R:C203	R:R:W116	9.14	No	Yes	8	9	8
117	R:R:L122	R:R:M118	5.65	No	No	0	6	7
118	R:R:G119	R:R:P120	4.06	No	No	0	8	3
119	R:R:H124	R:R:P120	3.05	No	No	0	7	3
120	R:R:P120	R:R:Y189	11.13	No	No	0	3	5
121	R:R:L122	R:R:V121	2.98	No	No	0	6	2
122	R:R:C123	R:R:C203	7.28	No	No	8	9	9
123	R:R:H124	R:R:R187	4.51	No	No	0	7	6
124	R:R:P127	R:R:V126	3.53	Yes	No	0	5	5
125	R:R:P127	R:R:Q130	4.74	Yes	No	0	5	6
126	R:R:L183	R:R:P127	6.57	No	Yes	0	5	5
127	R:R:P127	R:R:R187	5.76	Yes	No	0	5	6
128	R:R:L132	R:R:Y128	3.52	Yes	No	0	5	6
129	R:R:A180	R:R:Y128	4	No	No	0	7	6
130	R:R:L132	R:R:W173	4.56	Yes	Yes	0	5	9
131	R:R:L132	R:R:S176	3	Yes	No	0	5	8
132	R:R:Q135	R:R:S176	8.66	No	No	0	6	8
133	R:R:L179	R:R:Q135	11.98	No	No	0	5	6
134	R:R:L227	R:R:Q135	5.32	No	No	0	6	6
135	R:R:V136	R:R:W173	11.03	No	Yes	0	7	9
136	R:R:S176	R:R:V136	3.23	No	No	0	8	7
137	R:R:L227	R:R:T138	4.42	No	No	0	6	8
138	R:R:P231	R:R:T138	3.5	No	No	0	9	8
139	R:R:A172	R:R:I139	4.87	No	No	0	7	5
140	R:R:L141	R:R:Y325	5.86	No	Yes	0	8	9
141	R:R:I234	R:R:T142	3.04	No	No	0	6	7
142	R:R:I144	R:R:R148	3.76	Yes	No	3	9	9
143	R:R:I144	R:R:Y325	4.84	Yes	Yes	3	9	9
144	R:R:A145	R:R:Y239	4	No	Yes	0	9	9
145	R:R:R148	R:R:Y239	9.26	No	Yes	0	9	9
146	R:R:R148	R:R:Y325	5.14	No	Yes	3	9	9
147	R:R:H149	R:R:V153	19.37	No	No	9	8	7
148	R:R:H149	R:R:S238	8.37	No	No	0	8	7
149	R:R:H149	R:R:R241	7.9	No	No	9	8	4
150	R:R:I160	R:R:R150	5.01	No	No	0	5	4
151	R:R:C151	R:R:K159	3.23	No	No	0	8	5
152	R:R:I152	R:R:I242	7.36	No	No	0	8	8
153	R:R:V153	R:R:Y154	7.57	No	No	0	7	7
154	R:R:R241	R:R:V153	3.92	No	No	9	4	7
155	R:R:E157	R:R:Y154	4.49	No	No	0	4	7
156	R:R:H155	R:R:L156	6.43	No	No	0	8	5
157	R:R:H155	R:R:K245	7.86	No	No	0	8	5
158	R:R:E157	R:R:L156	3.98	No	No	0	4	5
159	R:R:I160	R:R:I164	4.42	No	No	0	5	5
160	R:R:R163	R:R:S161	14.5	No	No	10	5	6
161	R:R:I164	R:R:S161	3.1	No	No	10	5	6
162	R:R:I164	R:R:R163	3.76	No	No	10	5	5
163	R:R:G170	R:R:I169	3.53	No	No	0	4	7
164	R:R:P182	R:R:S181	3.56	No	No	0	8	4
165	R:R:I185	R:R:S181	4.64	No	No	0	4	4
166	R:R:L183	R:R:Y219	7.03	No	Yes	0	5	6
167	R:R:F186	R:R:I185	7.54	No	No	0	5	4
168	R:R:F186	R:R:W207	10.02	No	Yes	4	5	5
169	R:R:F186	R:R:P208	4.33	No	No	4	5	4
170	R:R:C203	R:R:R187	4.18	No	No	0	9	6
171	R:R:E188	R:R:T204	4.23	Yes	No	1	4	4
172	R:R:E188	R:R:K206	13.5	Yes	No	1	4	3
173	R:R:V201	R:R:Y189	12.62	No	No	0	4	5
174	R:R:E199	R:R:L191	5.3	No	No	0	4	3
175	R:R:L191	R:R:V201	2.98	No	No	0	3	4
176	R:R:I194	R:R:P196	3.39	No	No	1	1	3
177	R:R:F198	R:R:I194	7.54	No	No	1	1	1
178	R:R:I195	R:R:P196	5.08	No	No	0	2	3
179	R:R:F198	R:R:P196	8.67	No	No	1	1	3
180	R:R:A202	R:R:T204	3.36	No	No	1	4	4
181	R:R:E205	R:R:W207	6.54	No	Yes	0	4	5
182	R:R:P208	R:R:W207	6.76	No	Yes	4	4	5
183	R:R:W207	R:R:Y215	4.82	Yes	No	4	5	3
184	R:R:W207	R:R:Y219	3.86	Yes	Yes	0	5	6
185	R:R:P208	R:R:Y215	4.17	No	No	4	4	3
186	R:R:E210	R:R:E211	3.81	No	No	0	1	2
187	R:R:S213	R:R:Y215	6.36	No	No	0	2	3
188	R:R:L289	R:R:S220	6.01	No	No	0	5	4
189	R:R:D292	R:R:S220	7.36	No	No	0	5	4
190	R:R:L225	R:R:V229	2.98	No	No	0	5	4
191	R:R:L232	R:R:Y228	3.52	Yes	No	0	5	8
192	R:R:L282	R:R:Y228	3.52	No	No	0	5	8
193	R:R:L230	R:R:P231	3.28	No	No	0	6	9
194	R:R:I235	R:R:Y239	4.84	No	Yes	0	8	9
195	R:R:F237	R:R:R241	9.62	No	No	0	4	4
196	R:R:L270	R:R:Y239	5.86	No	Yes	0	8	9
197	R:R:K247	R:R:W243	10.44	No	Yes	5	6	5
198	R:R:R263	R:R:W243	5	Yes	Yes	5	7	5
199	R:R:T267	R:R:W243	7.28	No	Yes	5	6	5
200	R:R:N248	R:R:S244	2.98	No	No	0	4	4
201	R:R:L246	R:R:R263	13.36	No	Yes	0	8	7
202	R:R:K247	R:R:R263	7.43	No	Yes	5	6	7
203	R:R:H249	R:R:Y259	15.24	No	No	0	6	4
204	R:R:P252	R:R:S251	3.56	No	No	11	4	4
205	R:R:N256	R:R:S251	10.43	No	No	11	4	4
206	R:R:N256	R:R:P252	8.15	No	No	11	4	4
207	R:R:H258	R:R:Q261	4.95	No	No	0	4	4
208	R:R:H258	R:R:R262	14.67	No	No	0	4	5
209	R:R:H260	R:R:Y259	3.27	No	No	0	4	4
210	R:R:R263	R:R:T266	10.35	Yes	No	0	7	8
211	R:R:R263	R:R:T267	10.35	Yes	No	5	7	6
212	R:R:K268	R:R:Q264	5.42	No	No	0	6	5
213	R:R:K265	R:R:M328	4.32	No	No	0	8	7
214	R:R:K268	R:R:T267	3	No	No	0	6	6
215	R:R:M269	R:R:M328	11.55	No	No	0	8	7
216	R:R:L324	R:R:V273	5.96	No	No	0	8	8
217	R:R:V273	R:R:Y325	6.31	No	Yes	0	8	9
218	R:R:L324	R:R:V276	4.47	No	No	0	8	6
219	R:R:S280	R:R:S317	4.89	No	No	0	8	9
220	R:R:H285	R:R:W281	5.29	No	Yes	0	7	8
221	R:R:A314	R:R:W281	3.89	No	Yes	0	7	8
222	R:R:S317	R:R:W281	4.94	No	Yes	0	9	8
223	R:R:L282	R:R:P283	4.93	No	No	0	5	9
224	R:R:F310	R:R:P283	10.11	No	No	0	6	9
225	R:R:H311	R:R:L284	3.86	Yes	No	0	5	6
226	R:R:A314	R:R:L284	4.73	No	No	0	7	6
227	R:R:F287	R:R:V291	5.24	Yes	No	2	4	4
228	R:R:F287	R:R:Y303	9.28	Yes	Yes	2	4	4
229	R:R:F287	R:R:I306	3.77	Yes	No	0	4	5
230	R:R:F287	R:R:F307	4.29	Yes	No	0	4	4
231	R:R:F287	R:R:F310	3.22	Yes	No	0	4	6
232	R:R:F307	R:R:Q288	4.68	No	No	0	4	5
233	R:R:V291	R:R:Y303	6.31	No	Yes	2	4	4
234	R:R:D294	R:R:Q296	9.14	No	No	0	2	5
235	R:R:L298	R:R:Q296	11.98	No	No	0	1	5
236	R:R:V297	R:R:Y303	5.05	No	Yes	2	6	4
237	R:R:E302	R:R:L305	6.63	No	No	0	3	1
238	R:R:H311	R:R:M315	10.51	Yes	Yes	6	5	7
239	R:R:C316	R:R:F319	6.98	No	No	0	5	7
240	R:R:G326	R:R:Y332	4.35	No	Yes	0	7	8
241	R:R:R333	R:R:W327	9	No	No	0	8	6
242	R:R:N329	R:R:Y332	9.3	No	Yes	0	8	8
243	R:R:I144	R:R:I89	2.94	Yes	No	0	9	8
244	L:L:L24	R:R:I41	2.85	Yes	No	0	0	3
245	R:R:I47	R:R:L46	2.85	No	No	0	2	2
246	R:R:I234	R:R:L146	2.85	No	No	0	6	6
247	R:R:I175	R:R:L171	2.85	No	No	0	4	3
248	R:R:I293	R:R:L289	2.85	No	No	0	4	5
249	R:R:I169	R:R:N91	2.83	No	No	0	7	9
250	R:R:D42	R:R:K45	2.77	No	No	0	3	3
251	R:R:L221	R:R:L225	2.77	No	No	0	4	5
252	R:R:L224	R:R:L225	2.77	No	No	0	5	5
253	R:R:L224	R:R:L289	2.77	No	No	0	5	5
254	L:L:N29	R:R:L300	2.75	No	No	0	0	1
255	L:L:L30	R:R:E205	2.65	No	No	0	0	4
256	R:R:F78	R:R:S338	2.64	Yes	No	0	5	4
257	R:R:F87	R:R:S165	2.64	No	No	0	5	7
258	R:R:F78	R:R:V74	2.62	Yes	No	0	5	7
259	R:R:D299	R:R:E302	2.6	No	No	0	1	3
260	R:R:E193	R:R:E199	2.54	No	No	0	2	4
261	R:R:S238	R:R:Y239	2.54	No	Yes	0	7	9
262	R:R:V74	R:R:Y332	2.52	No	Yes	0	7	8
263	R:R:V274	R:R:Y239	2.52	No	Yes	0	8	9
264	R:R:F88	R:R:I168	2.51	Yes	No	0	7	5
265	R:R:M328	R:R:R333	2.48	No	No	0	7	8
266	R:R:V134	R:R:W281	2.45	No	Yes	0	7	8
267	R:R:F277	R:R:L141	2.44	No	No	0	9	8
268	R:R:F277	R:R:L232	2.44	No	Yes	0	9	5
269	R:R:I242	R:R:Y239	2.42	No	Yes	0	8	9
270	R:R:L246	R:R:Y259	2.34	No	No	0	8	4
271	R:R:L98	R:R:W173	2.28	No	Yes	0	7	9
272	R:R:F166	R:R:F87	2.14	No	No	0	4	5
273	R:R:A177	R:R:G174	1.95	No	No	0	4	4
274	L:L:A23	L:L:P5	1.87	No	Yes	0	0	0
275	R:R:G67	R:R:I66	1.76	No	No	0	8	4
276	L:L:G9	L:L:M17	1.75	No	No	0	0	0
277	R:R:G114	R:R:M113	1.75	No	No	0	5	4
278	R:R:P231	R:R:T142	1.75	No	No	0	9	7
279	R:R:G64	R:R:L63	1.71	No	No	0	7	6
280	R:R:G131	R:R:L183	1.71	No	No	0	4	5
281	R:R:G233	R:R:L232	1.71	No	Yes	0	3	5
282	R:R:A339	R:R:S338	1.71	No	No	0	4	4
283	R:R:A133	R:R:V99	1.7	No	No	0	7	7
284	R:R:A320	R:R:V276	1.7	No	No	0	6	6
285	R:R:I313	R:R:P283	1.69	No	No	0	7	9
286	R:R:C58	R:R:I54	1.64	No	No	0	4	6
287	L:L:N7	L:L:P8	1.63	No	No	0	0	0
288	R:R:S69	R:R:V65	1.62	No	No	0	4	6
289	R:R:S222	R:R:V218	1.62	No	No	0	3	4
290	R:R:C272	R:R:M269	1.62	No	No	0	6	8
291	R:R:S236	R:R:T240	1.6	No	No	0	5	3
292	R:R:V271	R:R:V275	1.6	No	No	0	6	4
293	R:R:V275	R:R:V279	1.6	No	No	0	4	6
294	R:R:A129	R:R:L102	1.58	No	No	0	5	5
295	R:R:A177	R:R:L132	1.58	No	Yes	0	4	5
296	R:R:A278	R:R:L232	1.58	No	Yes	0	5	5
297	R:R:C151	R:R:D147	1.56	No	No	0	8	8
298	R:R:I139	R:R:V143	1.54	No	No	0	5	7
299	R:R:K301	R:R:S43	1.53	No	No	0	3	5
300	R:R:I293	R:R:T217	1.52	No	No	0	4	3
301	R:R:L63	R:R:S59	1.5	No	No	0	6	5
302	R:R:L46	R:R:V49	1.49	No	No	0	2	4
303	R:R:L53	R:R:V49	1.49	No	No	0	5	4
304	R:R:L305	R:R:V49	1.49	No	No	0	1	4
305	R:R:L53	R:R:V52	1.49	No	No	0	5	5
306	R:R:I72	R:R:I76	1.47	No	No	0	7	3
307	R:R:L270	R:R:T266	1.47	No	No	0	8	8
308	R:R:G216	R:R:Y219	1.45	No	Yes	0	4	6
309	R:R:E188	R:R:S190	1.44	Yes	No	0	4	1
310	R:R:I175	R:R:L178	1.43	No	No	0	4	4
311	R:R:I226	R:R:L227	1.43	No	No	0	4	6
312	R:R:I226	R:R:L230	1.43	No	No	0	4	6
313	R:R:L112	R:R:M113	1.41	No	No	0	4	4
314	R:R:L324	R:R:M269	1.41	No	No	0	8	8
315	R:R:M81	R:R:N331	1.4	No	No	0	8	6
316	R:R:D294	R:R:I293	1.4	No	No	0	2	4
317	L:L:D6	L:L:N7	1.35	No	No	0	0	0
318	R:R:E210	R:R:K212	1.35	No	No	0	1	3
319	R:R:A184	R:R:Y128	1.33	No	No	0	5	6
320	R:R:D257	R:R:Q261	1.31	No	No	0	4	4
321	R:R:F310	R:R:V309	1.31	No	No	0	6	6
322	R:R:F106	R:R:T109	1.3	No	No	0	5	4
323	R:R:H124	R:R:L125	1.29	No	No	0	7	5
324	R:R:S244	R:R:W243	1.24	No	Yes	0	4	5
325	R:R:F106	R:R:L102	1.22	No	No	0	5	5
326	R:R:L337	R:R:R333	1.21	No	No	0	4	8
327	L:L:D16	L:L:R19	1.19	No	No	0	0	0
328	R:R:E157	R:R:R150	1.16	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:K4	6.0025	4	1	0
2	L:L:P5	4.275	4	1	0
3	L:L:Y20	4.26	4	1	0
4	L:L:L24	3.895	4	1	0
5	L:L:I31	4.408	5	1	0
6	L:L:R33	7.578	5	2	0
7	L:L:Q34	7.105	4	0	0
8	L:L:R35	7.186	5	2	0
9	L:L:Y36	4.205	4	0	0
10	R:R:Y57	6.515	4	0	7
11	R:R:N68	6.155	4	0	9
12	R:R:F78	5.4575	4	0	5
13	R:R:F88	4.89667	6	3	7
14	R:R:N100	5.7125	4	0	6
15	R:R:W116	9.82	4	8	8
16	R:R:P127	5.15	4	0	5
17	R:R:L132	3.165	4	0	5
18	R:R:I144	4.14	4	3	9
19	R:R:W173	5.88	4	0	9
20	R:R:E188	6.195	4	1	4
21	R:R:W207	6.4	5	4	5
22	R:R:Y219	5.915	4	0	6
23	R:R:L232	2.3125	4	0	5
24	R:R:Y239	4.49143	7	0	9
25	R:R:W243	5.99	4	5	5
26	R:R:R263	9.298	5	5	7
27	R:R:W281	4.1425	4	0	8
28	R:R:F287	5.16	5	2	4
29	R:R:Y303	6.0325	4	2	4
30	R:R:H311	6	5	6	5
31	R:R:M315	5.6625	4	6	7
32	R:R:Y325	5.5375	4	3	9
33	R:R:Y332	7.28286	7	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K4	L:L:P5	16.3217	3.35	Yes	Yes	1	0	0
2	L:L:I31	R:R:I192	25.6751	4.42	Yes	No	1	0	2
3	L:L:I31	L:L:T32	39.2667	3.04	Yes	No	0	0	0
4	L:L:T32	R:R:Y110	40.4889	11.24	No	No	0	0	5
5	L:L:Q34	R:R:Y110	57.9785	12.4	Yes	No	0	0	5
6	L:L:Q34	R:R:F307	64.4589	4.68	Yes	No	0	0	4
7	R:R:F287	R:R:F307	59.5801	4.29	Yes	No	0	4	4
8	R:R:F287	R:R:Y303	10.6052	9.28	Yes	Yes	2	4	4
9	R:R:F307	R:R:Q288	38.3255	4.68	No	No	0	4	5
10	L:L:R33	R:R:Q288	10.2848	3.5	Yes	No	2	0	5
11	L:L:R35	R:R:Q288	27.3704	5.84	Yes	No	2	0	5
12	L:L:R33	R:R:E205	12.2856	3.49	Yes	No	0	0	4
13	R:R:F287	R:R:V291	32.2541	5.24	Yes	No	2	4	4
14	L:L:R33	R:R:D292	14.7102	11.91	Yes	No	2	0	5
15	L:L:Q34	R:R:T107	33.6783	7.09	Yes	No	0	0	6
16	L:L:R35	L:L:Y36	21.8017	3.09	Yes	Yes	0	0	0
17	L:L:R35	R:R:Y219	21.9988	11.32	Yes	Yes	0	0	6
18	R:R:W116	R:R:Y110	24.2362	9.65	Yes	No	0	8	5
19	R:R:C203	R:R:W116	18.495	9.14	No	Yes	8	9	8
20	R:R:C203	R:R:R187	17.9874	4.18	No	No	0	9	6
21	R:R:P127	R:R:Q130	13.1924	4.74	Yes	No	0	5	6
22	R:R:H311	R:R:T107	33.0672	6.85	Yes	No	0	5	6
23	R:R:H311	R:R:Y57	38.8478	4.36	Yes	Yes	0	5	7
24	R:R:T308	R:R:Y57	18.15	6.24	No	Yes	0	3	7
25	R:R:L53	R:R:T308	16.6913	7.37	No	No	0	5	3
26	R:R:L53	R:R:V49	13.7443	1.49	No	No	0	5	4
27	R:R:L108	R:R:Y57	10.7579	8.21	No	Yes	0	6	7
28	R:R:I312	R:R:Y57	10.7579	7.25	No	Yes	0	5	7
29	R:R:H311	R:R:M315	37.7045	10.51	Yes	Yes	6	5	7
30	R:R:L104	R:R:M315	37.877	4.24	No	Yes	0	7	7
31	R:R:L104	R:R:N100	37.532	4.12	No	Yes	0	7	6
32	R:R:N100	R:R:V65	36.9702	4.43	Yes	No	0	6	6
33	R:R:L97	R:R:V65	36.5661	2.98	No	No	0	7	6
34	R:R:L97	R:R:N68	36.369	8.24	No	Yes	0	7	9
35	R:R:D96	R:R:N68	34.8512	6.73	No	Yes	0	9	9
36	R:R:F287	R:R:F310	91.7406	3.22	Yes	No	0	4	6
37	R:R:F310	R:R:P283	91.3069	10.11	No	No	0	6	9
38	R:R:L282	R:R:P283	90.8535	4.93	No	No	0	5	9
39	R:R:L282	R:R:Y228	90.6318	3.52	No	No	0	5	8
40	R:R:L232	R:R:Y228	90.4297	3.52	Yes	No	0	5	8
41	R:R:F277	R:R:L232	89.8236	2.44	No	Yes	0	9	5
42	R:R:F277	R:R:L141	89.6363	2.44	No	No	0	9	8
43	R:R:L141	R:R:Y325	100	5.86	No	Yes	0	8	9
44	R:R:I144	R:R:Y325	44.3229	4.84	Yes	Yes	3	9	9
45	R:R:I144	R:R:I89	28.8981	2.94	Yes	No	0	9	8
46	R:R:I89	R:R:Y332	27.464	13.3	No	Yes	0	8	8
47	R:R:V74	R:R:Y332	14.1435	2.52	No	Yes	0	7	8
48	R:R:F88	R:R:I144	23.1323	5.02	Yes	Yes	3	7	9
49	R:R:L141	R:R:L92	65.8338	5.54	No	No	0	8	9
50	R:R:L92	R:R:T140	50.5569	7.37	No	No	0	9	8
51	R:R:N91	R:R:T140	49.3249	13.16	No	No	0	9	8
52	R:R:N91	R:R:W173	45.5697	5.65	No	Yes	0	9	9
53	R:R:D96	R:R:N321	34.792	6.73	No	No	0	9	9
54	R:R:V136	R:R:W173	18.697	11.03	No	Yes	0	7	9
55	R:R:P127	R:R:V126	18.8941	3.53	Yes	No	0	5	5
56	R:R:F106	R:R:V126	15.134	10.49	No	No	0	5	5
57	R:R:H124	R:R:R187	17.1792	4.51	No	No	0	7	6
58	R:R:H124	R:R:P120	14.1435	3.05	No	No	0	7	3
59	R:R:P120	R:R:Y189	11.0684	11.13	No	No	0	3	5
60	R:R:L183	R:R:P127	12.3596	6.57	No	Yes	0	5	5
61	R:R:L132	R:R:W173	24.4333	4.56	Yes	Yes	0	5	9
62	R:R:L132	R:R:S176	16.1542	3	Yes	No	0	5	8
63	R:R:S176	R:R:V136	15.9373	3.23	No	No	0	8	7
64	R:R:Q135	R:R:S176	29.1199	8.66	No	No	0	6	8
65	R:R:L227	R:R:Q135	23.3737	5.32	No	No	0	6	6
66	R:R:L227	R:R:T138	14.6363	4.42	No	No	0	6	8
67	R:R:P231	R:R:T138	11.7288	3.5	No	No	0	9	8
68	R:R:R148	R:R:Y325	45.3528	5.14	No	Yes	3	9	9
69	R:R:R148	R:R:Y239	50.2809	9.26	No	Yes	0	9	9
70	R:R:S238	R:R:Y239	23.014	2.54	No	Yes	0	7	9
71	R:R:H149	R:R:S238	21.5405	8.37	No	No	0	8	7
72	R:R:H149	R:R:V153	16.9525	19.37	No	No	9	8	7
73	R:R:V153	R:R:Y154	15.5381	7.57	No	No	0	7	7
74	R:R:E157	R:R:Y154	14.0154	4.49	No	No	0	4	7
75	R:R:E205	R:R:W207	10.0089	6.54	No	Yes	0	4	5
76	R:R:D292	R:R:S220	21.9495	7.36	No	No	0	5	4
77	R:R:L289	R:R:S220	20.003	6.01	No	No	0	5	4
78	R:R:L270	R:R:Y239	21.4764	5.86	No	Yes	0	8	9
79	R:R:L270	R:R:T266	19.9783	1.47	No	No	0	8	8
80	R:R:R263	R:R:T266	18.5492	10.35	Yes	No	0	7	8
81	R:R:V273	R:R:Y325	17.1792	6.31	No	Yes	0	8	9
82	R:R:L324	R:R:V273	15.6663	5.96	No	No	0	8	8
83	R:R:L324	R:R:M269	11.0635	1.41	No	No	0	8	8
84	R:R:I293	R:R:L289	10.1222	2.85	No	No	0	4	5
85	L:L:K4	R:R:I192	22.9007	4.36	Yes	No	1	0	2
86	L:L:R33	R:R:V291	34.7526	10.46	Yes	No	2	0	4
87	L:L:R33	L:L:R35	18.5689	8.53	Yes	Yes	2	0	0
88	L:L:Y36	R:R:Q130	14.6954	3.38	Yes	No	0	0	6
89	R:R:L92	R:R:N321	35.2011	4.12	No	No	0	9	9
90	R:R:L183	R:R:Y219	15.3755	7.03	No	Yes	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:E188	5.61	1	No	Yes	0	4	0	1
L:L:Y1	R:R:K206	5.97	1	No	No	0	3	0	1
L:L:K4	R:R:I192	4.36	1	Yes	No	0	2	0	1
L:L:K4	R:R:I194	4.36	1	Yes	No	0	1	0	1
L:L:Y21	R:R:L40	5.86	1	No	No	0	7	0	1
L:L:R25	R:R:S43	3.95	0	No	No	0	5	0	1
L:L:R25	R:R:L300	13.36	0	No	No	0	1	0	1
L:L:H26	R:R:V297	4.15	0	No	No	0	6	0	1
L:L:Y27	R:R:I192	9.67	1	No	No	0	2	0	1
L:L:N29	R:R:V297	4.43	2	No	No	0	6	0	1
L:L:N29	R:R:Y303	3.49	2	No	Yes	0	4	0	1
L:L:I31	R:R:I192	4.42	1	Yes	No	0	2	0	1
L:L:I31	R:R:A202	3.25	1	Yes	No	0	4	0	1
L:L:I31	R:R:T204	4.56	1	Yes	No	0	4	0	1
L:L:T32	R:R:Y110	11.24	0	No	No	0	5	0	1
L:L:R33	R:R:E205	3.49	2	Yes	No	0	4	0	1
L:L:R33	R:R:Q288	3.5	2	Yes	No	0	5	0	1
L:L:R33	R:R:V291	10.46	2	Yes	No	0	4	0	1
L:L:R33	R:R:D292	11.91	2	Yes	No	0	5	0	1
L:L:Q34	R:R:T107	7.09	0	Yes	No	0	6	0	1
L:L:Q34	R:R:Y110	12.4	0	Yes	No	0	5	0	1
L:L:Q34	R:R:T111	4.25	0	Yes	No	0	4	0	1
L:L:Q34	R:R:F307	4.68	0	Yes	No	0	4	0	1
L:L:R35	R:R:Y219	11.32	2	Yes	Yes	0	6	0	1
L:L:R35	R:R:Q288	5.84	2	Yes	No	0	5	0	1
L:L:R35	R:R:D292	7.15	2	Yes	No	0	5	0	1
L:L:Y36	R:R:Q130	3.38	0	Yes	No	0	6	0	1
L:L:Y36	R:R:S223	3.82	0	Yes	No	0	5	0	1
L:L:Y36	R:R:H285	6.53	0	Yes	No	0	7	0	1
R:R:E39	R:R:I41	15.03	0	No	No	3	3	2	1
R:R:H311	R:R:T107	6.85	6	Yes	No	5	6	2	1
R:R:W116	R:R:Y110	9.65	8	Yes	No	8	5	2	1
R:R:K304	R:R:T111	3	0	No	No	4	4	2	1
R:R:P127	R:R:Q130	4.74	0	Yes	No	5	6	2	1
R:R:L183	R:R:P127	6.57	0	No	Yes	5	5	2	2
R:R:L183	R:R:Y219	7.03	0	No	Yes	5	6	2	1
R:R:E188	R:R:T204	4.23	1	Yes	No	4	4	1	1
R:R:E188	R:R:K206	13.5	1	Yes	No	4	3	1	1
R:R:I194	R:R:P196	3.39	1	No	No	1	3	1	2
R:R:F198	R:R:I194	7.54	1	No	No	1	1	2	1
R:R:F198	R:R:P196	8.67	1	No	No	1	3	2	2
R:R:A202	R:R:T204	3.36	1	No	No	4	4	1	1
R:R:E205	R:R:W207	6.54	0	No	Yes	4	5	1	2
R:R:W207	R:R:Y219	3.86	4	Yes	Yes	5	6	2	1
R:R:D292	R:R:S220	7.36	2	No	No	5	4	1	2
R:R:H285	R:R:W281	5.29	0	No	Yes	7	8	1	2
R:R:F287	R:R:V291	5.24	2	Yes	No	4	4	2	1
R:R:F287	R:R:Y303	9.28	2	Yes	Yes	4	4	2	1
R:R:F287	R:R:F307	4.29	2	Yes	No	4	4	2	1
R:R:F307	R:R:Q288	4.68	0	No	No	4	5	1	1
R:R:V291	R:R:Y303	6.31	2	No	Yes	4	4	1	1
R:R:V297	R:R:Y303	5.05	2	No	Yes	6	4	1	1
L:L:L24	R:R:I41	2.85	1	Yes	No	0	3	0	1
L:L:N29	R:R:L300	2.75	2	No	No	0	1	0	1
L:L:L30	R:R:E205	2.65	0	No	No	0	4	0	1
R:R:K301	R:R:S43	1.53	0	No	No	3	5	2	1
R:R:G216	R:R:Y219	1.45	0	No	Yes	4	6	2	1
R:R:E188	R:R:S190	1.44	1	Yes	No	4	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8K6N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	307
Number of Links	328
Number of Hubs	33
Number of Links mediated by Hubs	132
Number of Communities	11
Number of Nodes involved in Communities	58
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	49431
Length Of Smallest Path	3
Average Path Length	15.6039
Length of Longest Path	35
Minimum Path Strength	1.26
Average Path Strength	5.78369
Maximum Path Strength	13.87
Minimum Path Correlation	0.7
Average Path Correlation	0.942192
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	57.4346
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.1073
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide Y receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • transporter regulator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • nerve growth factor production • multicellular organismal process • regulation of nerve growth factor production • regulation of multicellular organismal process • neurotrophin production • regulation of neurotrophin production • developmental process • cellular developmental process • central nervous system neuron development • cell development • nervous system development • generation of neurons • central nervous system neuron differentiation • multicellular organism development • neurogenesis • central nervous system development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • system development • response to light stimulus • photoperiodism • response to radiation • response to abiotic stimulus • short-day photoperiodism • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • cell adhesion • positive regulation of cell-substrate adhesion • epithelium development • digestive system development • intestinal epithelial cell differentiation • tube development • tissue development • digestive tract development • epithelial cell differentiation • columnar/cuboidal epithelial cell differentiation • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • positive regulation of dopamine metabolic process • regulation of primary metabolic process • amine metabolic process • positive regulation of metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • positive regulation of amine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response to antigenic stimulus • response to stress • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • acute inflammatory response • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • regulation of acute inflammatory response • inflammatory response • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • response to chemical • regulation of biological quality • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • behavior • feeding behavior • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • head development • forebrain development • animal organ development • brain development • pallium development • cerebral cortex development • telencephalon development • monocyte activation • cell activation • myeloid leukocyte activation • leukocyte activation • synaptic signaling • cell-cell signaling • synaptic signaling via neuropeptide • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of localization • cellular localization • regulated exocytosis • transport • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • localization • regulation of secretion by cell • secretion by cell • signal release • establishment of localization in cell • neurotransmitter secretion • regulation of transport • secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • export from cell • neurotransmitter transport • regulation of vesicle-mediated transport • establishment of localization • regulation of secretion • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • regulation of exocytosis • adult feeding behavior • adult behavior • plasma membrane bounded cell projection organization • cell projection organization • neuron projection development • cellular component organization • cellular component organization or biogenesis • system process • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • perikaryon • neuronal cell body • dense core granule • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • axon • axon terminus • presynapse • distal axon • terminal bouton • neuron projection terminus • GABA-ergic synapse • Golgi apparatus • perinuclear region of cytoplasm • peptide receptor activity • neuropeptide Y receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • peptide YY receptor activity • positive regulation of cytosolic calcium ion concentration • locomotory behavior • nitric oxide mediated signal transduction • negative regulation of transport • negative regulation of secretion • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, non-REM sleep • regulation of circadian rhythm • circadian sleep/wake cycle, non-REM sleep • sleep • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • positive regulation of circadian sleep/wake cycle, non-REM sleep • circadian rhythm • circadian behavior • positive regulation of circadian rhythm • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of peptide secretion • nitrogen compound transport • regulation of peptide secretion • regulation of peptide transport • peptide transport • peptide secretion • positive regulation of secretion • positive regulation of transport • amide transport • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • heart development • cardiac chamber morphogenesis • heart morphogenesis • circulatory system development • anatomical structure morphogenesis • cardiac ventricle morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac left ventricle morphogenesis • cardiac ventricle development • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of cellular process • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of nervous system process • nervous system process • regulation of system process • regulation of nervous system process • negative regulation of multicellular organismal process • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • modulation of excitatory postsynaptic potential • cell surface receptor signaling pathway • negative regulation of excitatory postsynaptic potential • excitatory postsynaptic potential • regulation of membrane potential • behavioral defense response • fear response • behavioral fear response • multicellular organismal response to stress • negative regulation of feeding behavior • negative regulation of behavior • outflow tract morphogenesis • glutamatergic synapse • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • positive regulation of neural precursor cell proliferation • neural precursor cell proliferation • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • superoxide anion generation • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of monoatomic ion transport • metal ion transport • calcium ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulation of calcium ion-dependent exocytosis • negative regulation of regulated secretory pathway • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • negative regulation of calcium ion-dependent exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • response to nutrient • midbody • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49146
Sequence	>8K6N_nogp_Chain_R E L I D S T K L I E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F K S M R T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G E W K M G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R H R C I V Y H L E S K I S K R I S F L I I G L A W G I S A L L A S P L A I F R E Y S L I E I I P D F E I V A C T E K W P G E E K S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G A A N D H Y H Q R R Q K T T K M L V C V V V V F A V S W L P L H A F Q L A V D I D S Q V L D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N Y R K A F L S A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	doi.org/10.1038/s41586-020-1954-0
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	7WIH	C	Aminoacid	Metabotropic Glutamate	mGlu3; mGlu3	Homo sapiens	LY2794193	-	-	3.68	2022-03-16	doi.org/10.1038/s41422-022-00623-z
	7YON	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-	Gi1/β1/γ2	2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YON (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-		2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7DDZ	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	JNJ-31020028	-	-	2.8	2021-01-27	doi.org/10.1038/s41467-021-21030-9
	7X9B	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	7X9B (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	8K6N	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-	Gi2/β1/γ1	3.2	2024-07-31	doi.org/10.1002/mco2.565
	8K6N (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-		3.2	2024-07-31	doi.org/10.1002/mco2.565
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3

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