psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K4	L:L:Y27	4.78	No	Yes	4	0	0
2	L:L:K4	R:R:I194	4.36	No	Yes	4	0	1
3	L:L:P5	L:L:S23	5.34	No	No	0	0	0
4	L:L:L24	L:L:P5	4.93	Yes	No	0	0	0
5	L:L:L17	L:L:Y21	5.86	No	No	0	0	0
6	L:L:Y20	L:L:Y21	4.96	No	No	0	0	0
7	L:L:L24	L:L:Y20	9.38	Yes	No	0	0	0
8	L:L:R25	R:R:K301	9.9	No	No	0	0	3
9	L:L:H26	R:R:S295	4.18	No	No	0	0	1
10	L:L:H26	R:R:L298	10.29	No	Yes	0	0	1
11	L:L:H26	R:R:D299	7.56	No	No	0	0	1
12	L:L:V31	L:L:Y27	3.79	No	Yes	0	0	0
13	L:L:Y27	R:R:I192	3.63	Yes	Yes	4	0	2
14	L:L:Y27	R:R:I194	3.63	Yes	Yes	4	0	1
15	L:L:N29	R:R:Y303	10.47	No	Yes	0	0	4
16	L:L:L30	R:R:L298	4.15	No	Yes	0	0	1
17	L:L:T32	R:R:Y110	8.74	No	No	0	0	5
18	L:L:T32	R:R:K304	6.01	No	Yes	0	0	4
19	L:L:R33	L:L:R35	5.33	Yes	Yes	1	0	0
20	L:L:R33	R:R:E205	3.49	Yes	No	1	0	4
21	L:L:R33	R:R:Q288	4.67	Yes	No	0	0	5
22	L:L:R33	R:R:V291	6.54	Yes	No	0	0	4
23	L:L:R33	R:R:Y303	4.12	Yes	Yes	0	0	4
24	L:L:Q34	R:R:T107	12.76	Yes	No	0	0	6
25	L:L:Q34	R:R:Y110	10.15	Yes	No	0	0	5
26	L:L:Q34	R:R:T111	4.25	Yes	No	0	0	4
27	L:L:Q34	R:R:F307	3.51	Yes	No	0	0	4
28	L:L:?36	L:L:R35	5.13	Yes	Yes	1	0	0
29	L:L:R35	R:R:E205	8.14	Yes	No	1	0	4
30	L:L:R35	R:R:Y219	9.26	Yes	Yes	0	0	6
31	L:L:R35	R:R:S220	3.95	Yes	No	0	0	4
32	L:L:?36	R:R:T107	7.47	Yes	No	1	0	6
33	L:L:?36	R:R:Q130	7.87	Yes	No	0	0	6
34	L:L:?36	R:R:G131	2.89	Yes	No	0	0	4
35	L:L:?36	R:R:H311	7.61	Yes	Yes	1	0	5
36	R:R:I41	R:R:K45	4.36	No	No	0	3	3
37	R:R:E302	R:R:S43	8.62	No	No	0	3	5
38	R:R:E48	R:R:L46	10.6	No	No	0	2	2
39	R:R:L112	R:R:Q50	11.98	No	No	0	4	4
40	R:R:L104	R:R:Y57	7.03	Yes	Yes	0	7	7
41	R:R:L108	R:R:Y57	9.38	No	Yes	0	6	7
42	R:R:H311	R:R:Y57	7.62	Yes	Yes	0	5	7
43	R:R:I312	R:R:Y57	8.46	No	Yes	0	5	7
44	R:R:I60	R:R:S59	3.1	No	No	0	7	5
45	R:R:I61	R:R:N100	4.25	No	No	0	6	6
46	R:R:I61	R:R:L104	7.14	No	Yes	0	6	7
47	R:R:F319	R:R:L63	3.65	No	No	0	7	6
48	R:R:G64	R:R:N100	3.39	No	No	0	7	6
49	R:R:N68	R:R:P322	9.77	No	No	0	9	9
50	R:R:A93	R:R:V71	3.39	No	No	0	9	9
51	R:R:V71	R:R:Y332	5.05	No	Yes	0	9	8
52	R:R:I72	R:R:V94	3.07	No	No	0	7	6
53	R:R:H73	R:R:K77	3.93	No	No	0	4	5
54	R:R:F336	R:R:V74	6.55	Yes	No	0	6	7
55	R:R:V75	R:R:Y332	3.79	No	Yes	0	7	8
56	R:R:F78	R:R:K77	7.44	Yes	No	0	5	5
57	R:R:A339	R:R:K77	3.21	No	No	0	4	5
58	R:R:F78	R:R:S338	3.96	Yes	No	0	5	4
59	R:R:K79	R:R:R82	4.95	No	No	0	6	6
60	R:R:M81	R:R:N86	4.21	Yes	Yes	5	8	8
61	R:R:M81	R:R:Y332	9.58	Yes	Yes	5	8	8
62	R:R:F87	R:R:R82	4.28	No	No	0	5	6
63	R:R:N86	R:R:T83	5.85	Yes	No	0	8	7
64	R:R:I160	R:R:V84	3.07	No	No	0	5	6
65	R:R:K162	R:R:V84	4.55	No	No	0	1	6
66	R:R:S165	R:R:V84	4.85	No	No	0	7	6
67	R:R:N86	R:R:T85	2.92	Yes	No	0	8	8
68	R:R:D147	R:R:T85	4.34	No	No	0	8	8
69	R:R:N86	R:R:Y332	8.14	Yes	Yes	5	8	8
70	R:R:F87	R:R:K162	6.2	No	No	0	5	1
71	R:R:F166	R:R:F87	3.22	No	No	0	4	5
72	R:R:F88	R:R:V143	7.87	Yes	No	0	7	7
73	R:R:D147	R:R:F88	8.36	No	Yes	0	8	7
74	R:R:F88	R:R:I169	5.02	Yes	No	0	7	7
75	R:R:I89	R:R:Y332	6.04	No	Yes	0	8	8
76	R:R:N91	R:R:T140	2.92	No	No	0	9	8
77	R:R:I169	R:R:N91	7.08	No	No	0	7	9
78	R:R:N91	R:R:W173	6.78	No	No	0	9	9
79	R:R:D96	R:R:L92	5.43	Yes	Yes	2	9	9
80	R:R:L92	R:R:T140	5.9	Yes	No	0	9	8
81	R:R:L92	R:R:N321	5.49	Yes	No	2	9	9
82	R:R:L92	R:R:Y325	3.52	Yes	Yes	2	9	9
83	R:R:D96	R:R:S137	5.89	Yes	No	0	9	9
84	R:R:D96	R:R:N321	6.73	Yes	No	2	9	9
85	R:R:C103	R:R:V99	5.12	No	No	0	6	7
86	R:R:T318	R:R:V99	3.17	No	No	0	9	7
87	R:R:N100	R:R:T318	13.16	No	No	0	6	9
88	R:R:L102	R:R:T101	2.95	No	No	0	5	5
89	R:R:C103	R:R:Q130	6.1	No	No	0	6	6
90	R:R:L104	R:R:M315	9.9	Yes	No	0	7	7
91	R:R:F106	R:R:V126	10.49	No	Yes	0	5	5
92	R:R:H311	R:R:T107	9.58	Yes	No	1	5	6
93	R:R:L108	R:R:L112	5.54	No	No	0	6	4
94	R:R:M113	R:R:T109	3.01	No	No	0	4	4
95	R:R:W116	R:R:Y110	10.61	Yes	No	0	8	5
96	R:R:K304	R:R:T111	3	Yes	No	0	4	4
97	R:R:E115	R:R:K117	13.5	No	No	0	5	3
98	R:R:M118	R:R:W116	9.31	No	Yes	0	7	8
99	R:R:V126	R:R:W116	4.9	Yes	Yes	0	5	8
100	R:R:C203	R:R:W116	3.92	No	Yes	0	9	8
101	R:R:L122	R:R:M118	5.65	No	No	0	6	7
102	R:R:G119	R:R:P120	4.06	No	No	0	8	3
103	R:R:P120	R:R:Y189	8.34	No	No	0	3	5
104	R:R:L122	R:R:V121	2.98	No	No	0	6	2
105	R:R:L122	R:R:V126	2.98	No	Yes	0	6	5
106	R:R:C123	R:R:Y189	4.03	No	No	0	9	5
107	R:R:C123	R:R:C203	7.28	No	No	0	9	9
108	R:R:P127	R:R:V126	3.53	No	Yes	0	5	5
109	R:R:Q130	R:R:V126	4.3	No	Yes	0	6	5
110	R:R:P127	R:R:R187	10.09	No	No	0	5	6
111	R:R:L132	R:R:S176	3	No	No	0	5	8
112	R:R:V134	R:R:W281	4.9	No	Yes	0	7	8
113	R:R:Q135	R:R:S176	2.89	No	No	0	6	8
114	R:R:L179	R:R:Q135	3.99	No	No	0	5	6
115	R:R:L227	R:R:Q135	6.65	No	No	0	6	6
116	R:R:V136	R:R:W173	12.26	No	No	0	7	9
117	R:R:S176	R:R:V136	4.85	No	No	0	8	7
118	R:R:P231	R:R:T138	3.5	No	No	0	9	8
119	R:R:F277	R:R:L141	4.87	Yes	No	0	9	8
120	R:R:L141	R:R:Y325	4.69	No	Yes	0	8	9
121	R:R:I235	R:R:T142	3.04	No	No	0	8	7
122	R:R:I168	R:R:V143	3.07	No	No	0	5	7
123	R:R:I144	R:R:R148	6.26	No	No	2	9	9
124	R:R:I144	R:R:Y325	4.84	No	Yes	2	9	9
125	R:R:A145	R:R:I235	3.25	No	No	0	9	8
126	R:R:A145	R:R:S238	3.42	No	No	0	9	7
127	R:R:A145	R:R:Y239	4	No	Yes	0	9	9
128	R:R:R148	R:R:Y239	5.14	No	Yes	0	9	9
129	R:R:R148	R:R:Y325	6.17	No	Yes	2	9	9
130	R:R:V153	R:R:Y149	3.79	No	Yes	3	7	8
131	R:R:Y149	R:R:Y154	4.96	Yes	No	3	8	7
132	R:R:F237	R:R:Y149	5.16	No	Yes	3	4	8
133	R:R:S238	R:R:Y149	6.36	No	Yes	0	7	8
134	R:R:R241	R:R:Y149	5.14	No	Yes	3	4	8
135	R:R:I160	R:R:R150	7.52	No	No	0	5	4
136	R:R:V153	R:R:Y154	3.79	No	No	3	7	7
137	R:R:K245	R:R:V153	4.55	No	No	0	5	7
138	R:R:E157	R:R:Y154	3.37	No	No	0	4	7
139	R:R:H155	R:R:L156	5.14	No	No	0	8	5
140	R:R:H155	R:R:K245	5.24	No	No	0	8	5
141	R:R:F166	R:R:S165	3.96	No	No	0	4	7
142	R:R:L167	R:R:L171	5.54	No	No	0	3	3
143	R:R:P182	R:R:S181	5.34	No	No	0	8	4
144	R:R:F186	R:R:P182	2.89	Yes	No	0	5	8
145	R:R:L183	R:R:Y219	3.52	No	Yes	0	5	6
146	R:R:F186	R:R:I185	10.05	Yes	No	0	5	4
147	R:R:F186	R:R:W207	10.02	Yes	Yes	6	5	5
148	R:R:F186	R:R:P208	2.89	Yes	No	6	5	4
149	R:R:C203	R:R:R187	4.18	No	No	0	9	6
150	R:R:E205	R:R:R187	6.98	No	No	0	4	6
151	R:R:E188	R:R:S190	8.62	No	No	0	4	1
152	R:R:E188	R:R:T204	5.64	No	No	0	4	4
153	R:R:E188	R:R:K206	6.75	No	No	0	4	3
154	R:R:V201	R:R:Y189	8.83	No	No	0	4	5
155	R:R:I192	R:R:S190	3.1	Yes	No	0	2	1
156	R:R:I192	R:R:I194	2.94	Yes	Yes	4	2	1
157	R:R:I192	R:R:I200	5.89	Yes	No	0	2	3
158	R:R:E193	R:R:E199	20.3	No	No	0	2	4
159	R:R:I195	R:R:P196	5.08	No	No	0	2	3
160	R:R:F198	R:R:I195	12.56	No	No	0	1	2
161	R:R:P208	R:R:W207	4.05	No	Yes	6	4	5
162	R:R:W207	R:R:Y215	2.89	Yes	No	0	5	3
163	R:R:G216	R:R:W207	4.22	No	Yes	0	4	5
164	R:R:W207	R:R:Y219	2.89	Yes	Yes	0	5	6
165	R:R:G209	R:R:S213	3.71	No	No	0	4	2
166	R:R:K212	R:R:T217	3	No	No	0	3	3
167	R:R:S213	R:R:Y215	5.09	No	No	0	2	3
168	R:R:I214	R:R:Y215	3.63	No	No	0	1	3
169	R:R:D292	R:R:T217	5.78	No	No	0	5	3
170	R:R:D292	R:R:S220	7.36	No	No	0	5	4
171	R:R:L221	R:R:L289	5.54	No	No	0	4	5
172	R:R:L232	R:R:Y228	3.52	No	No	0	5	8
173	R:R:L282	R:R:Y228	10.55	No	No	0	5	8
174	R:R:L230	R:R:P231	3.28	No	No	0	6	9
175	R:R:F277	R:R:P231	2.89	Yes	No	0	9	9
176	R:R:F277	R:R:L232	3.65	Yes	No	0	9	5
177	R:R:F237	R:R:R241	4.28	No	No	3	4	4
178	R:R:L270	R:R:Y239	4.69	No	Yes	0	8	9
179	R:R:V273	R:R:Y239	3.79	No	Yes	0	8	9
180	R:R:S244	R:R:W243	3.71	No	No	0	4	5
181	R:R:K247	R:R:W243	5.8	No	No	0	6	5
182	R:R:T267	R:R:W243	6.06	No	No	0	6	5
183	R:R:L246	R:R:Y259	3.52	No	Yes	0	8	4
184	R:R:K247	R:R:N248	5.6	No	No	0	6	4
185	R:R:K247	R:R:R263	3.71	No	Yes	0	6	7
186	R:R:H249	R:R:Y259	11.98	No	Yes	0	6	4
187	R:R:N256	R:R:V250	2.96	No	No	0	4	4
188	R:R:P252	R:R:S251	3.56	No	No	0	4	4
189	R:R:N256	R:R:S251	4.47	No	No	0	4	4
190	R:R:S251	R:R:Y259	3.82	No	Yes	0	4	4
191	R:R:H260	R:R:N256	6.38	Yes	No	0	4	4
192	R:R:D257	R:R:Q261	13.05	No	No	0	4	4
193	R:R:H260	R:R:Y259	8.71	Yes	Yes	7	4	4
194	R:R:R263	R:R:Y259	3.09	Yes	Yes	7	7	4
195	R:R:H260	R:R:R263	6.77	Yes	Yes	7	4	7
196	R:R:Q264	R:R:R263	3.5	No	Yes	0	5	7
197	R:R:L324	R:R:M269	4.24	No	No	0	8	8
198	R:R:M269	R:R:M328	7.22	No	No	0	8	7
199	R:R:V273	R:R:Y325	6.31	No	Yes	0	8	9
200	R:R:F277	R:R:W281	5.01	Yes	Yes	0	9	8
201	R:R:C280	R:R:S317	3.44	No	No	0	8	9
202	R:R:H285	R:R:W281	4.23	No	Yes	0	7	8
203	R:R:A314	R:R:W281	5.19	No	Yes	0	7	8
204	R:R:L282	R:R:P283	3.28	No	No	0	5	9
205	R:R:F310	R:R:P283	8.67	No	No	0	6	9
206	R:R:A314	R:R:L284	3.15	No	No	0	7	6
207	R:R:F287	R:R:Y303	6.19	No	Yes	0	4	4
208	R:R:F287	R:R:I306	5.02	No	No	8	4	5
209	R:R:F287	R:R:F310	6.43	No	No	8	4	6
210	R:R:V291	R:R:V297	3.21	No	No	0	4	6
211	R:R:L298	R:R:V291	4.47	Yes	No	0	1	4
212	R:R:D294	R:R:I293	5.6	No	No	0	2	4
213	R:R:L298	R:R:Y303	4.69	Yes	Yes	0	1	4
214	R:R:E302	R:R:L305	6.63	No	No	0	3	1
215	R:R:F310	R:R:I306	3.77	No	No	8	6	5
216	R:R:H311	R:R:M315	7.88	Yes	No	0	5	7
217	R:R:C316	R:R:F319	5.59	No	No	0	5	7
218	R:R:G326	R:R:Y332	4.35	No	Yes	0	7	8
219	R:R:M328	R:R:W327	3.49	No	No	0	7	6
220	R:R:R333	R:R:W327	8	No	No	0	8	6
221	R:R:F336	R:R:W327	7.02	Yes	No	0	6	6
222	R:R:N329	R:R:Y332	10.47	No	Yes	0	8	8
223	R:R:N331	R:R:S330	2.98	No	No	0	6	5
224	R:R:F336	R:R:Y332	3.09	Yes	Yes	0	6	8
225	R:R:K117	R:R:M113	2.88	No	No	0	3	4
226	L:L:L24	R:R:I194	2.85	Yes	Yes	0	0	1
227	R:R:I54	R:R:L112	2.85	No	No	0	6	4
228	R:R:I60	R:R:L104	2.85	No	Yes	0	7	7
229	R:R:I66	R:R:L62	2.85	No	No	0	4	5
230	R:R:E115	R:R:V201	2.85	No	No	0	5	4
231	R:R:I234	R:R:L146	2.85	No	No	0	6	6
232	R:R:I234	R:R:L230	2.85	No	No	0	6	6
233	R:R:H285	R:R:S223	2.79	No	No	0	7	5
234	L:L:L24	R:R:L40	2.77	Yes	No	0	0	7
235	R:R:D42	R:R:K304	2.77	No	Yes	0	3	4
236	R:R:A335	R:R:F78	2.77	No	Yes	0	6	5
237	R:R:L224	R:R:L225	2.77	No	No	9	5	5
238	R:R:L323	R:R:L324	2.77	No	No	0	7	8
239	R:R:L97	R:R:N68	2.75	No	No	0	7	9
240	R:R:E302	R:R:K301	2.7	No	No	0	3	3
241	R:R:D96	R:R:N68	2.69	Yes	No	0	9	9
242	L:L:A7	L:L:Y20	2.67	No	No	0	0	0
243	R:R:A180	R:R:Y128	2.67	No	No	0	7	6
244	R:R:F88	R:R:S165	2.64	Yes	No	0	7	7
245	R:R:H285	R:R:L224	2.57	No	No	0	7	5
246	R:R:E210	R:R:E211	2.54	No	No	0	1	2
247	R:R:V274	R:R:Y239	2.52	No	Yes	0	8	9
248	R:R:T308	R:R:Y57	2.5	No	Yes	0	3	7
249	R:R:F78	R:R:M81	2.49	Yes	Yes	0	5	8
250	R:R:V94	R:R:W173	2.45	No	No	0	6	9
251	R:R:F336	R:R:L70	2.44	Yes	No	0	6	7
252	R:R:F340	R:R:L70	2.44	No	No	0	5	7
253	R:R:I242	R:R:Y239	2.42	No	Yes	0	8	9
254	R:R:H258	R:R:R262	2.26	No	No	0	4	5
255	R:R:G67	R:R:P322	2.03	No	No	0	8	9
256	R:R:G253	R:R:P252	2.03	No	No	0	4	4
257	R:R:A177	R:R:G174	1.95	No	No	0	4	4
258	R:R:G67	R:R:I66	1.76	No	No	0	8	4
259	R:R:G170	R:R:I169	1.76	No	No	0	4	7
260	R:R:G114	R:R:K304	1.74	No	Yes	0	5	4
261	R:R:G64	R:R:L63	1.71	No	No	0	7	6
262	R:R:A95	R:R:S137	1.71	No	No	0	8	9
263	R:R:C280	R:R:V276	1.71	No	No	0	8	6
264	L:L:V31	R:R:A202	1.7	No	No	0	0	4
265	R:R:A133	R:R:V99	1.7	No	No	0	7	7
266	R:R:A172	R:R:V136	1.7	No	No	0	7	7
267	R:R:A290	R:R:V297	1.7	No	No	0	5	6
268	R:R:C58	R:R:I54	1.64	No	No	0	4	6
269	R:R:L104	R:R:P105	1.64	Yes	No	0	7	8
270	R:R:C151	R:R:I152	1.64	No	No	0	8	8
271	R:R:A172	R:R:I139	1.62	No	No	0	7	5
272	R:R:C151	R:R:K159	1.62	No	No	0	8	5
273	R:R:S236	R:R:V274	1.62	No	No	0	5	8
274	R:R:C272	R:R:M269	1.62	No	No	0	6	8
275	R:R:V271	R:R:V275	1.6	No	No	0	6	4
276	R:R:V275	R:R:V279	1.6	No	No	0	4	6
277	L:L:T32	L:L:V31	1.59	No	No	0	0	0
278	R:R:T308	R:R:V309	1.59	No	No	0	3	6
279	R:R:A133	R:R:L98	1.58	No	No	0	7	7
280	R:R:A129	R:R:L102	1.58	No	No	0	5	5
281	R:R:A177	R:R:L132	1.58	No	No	0	4	5
282	R:R:A180	R:R:L132	1.58	No	No	0	7	5
283	R:R:A278	R:R:L232	1.58	No	No	0	5	5
284	R:R:C151	R:R:D147	1.56	No	No	0	8	8
285	R:R:I47	R:R:V51	1.54	No	No	0	2	6
286	R:R:I61	R:R:V65	1.54	No	No	0	6	6
287	R:R:I66	R:R:V65	1.54	No	No	0	4	6
288	R:R:K304	R:R:T44	1.5	Yes	No	0	4	4
289	R:R:L70	R:R:S69	1.5	No	No	0	7	4
290	R:R:L289	R:R:S220	1.5	No	No	0	5	4
291	R:R:L53	R:R:V49	1.49	No	No	0	5	4
292	R:R:L305	R:R:V49	1.49	No	No	0	1	4
293	R:R:L191	R:R:V201	1.49	No	No	0	3	4
294	R:R:L224	R:R:V229	1.49	No	No	9	5	4
295	R:R:L225	R:R:V229	1.49	No	No	9	5	4
296	R:R:L324	R:R:V276	1.49	No	No	0	8	6
297	R:R:I72	R:R:I76	1.47	No	No	0	7	3
298	R:R:C123	R:R:H124	1.47	No	No	0	9	7
299	R:R:L246	R:R:T266	1.47	No	No	0	8	8
300	R:R:L270	R:R:T266	1.47	No	No	0	8	8
301	R:R:L305	R:R:T308	1.47	No	No	0	1	3
302	L:L:L28	R:R:I194	1.43	No	Yes	0	0	1
303	L:L:L28	R:R:I200	1.43	No	No	0	0	3
304	R:R:I47	R:R:L46	1.43	No	No	0	2	2
305	R:R:I293	R:R:L289	1.43	No	No	0	4	5
306	R:R:M81	R:R:N331	1.4	Yes	No	0	8	6
307	R:R:K265	R:R:Q261	1.36	No	No	0	8	4
308	R:R:A184	R:R:Y128	1.33	No	No	0	5	6
309	R:R:D299	R:R:Q296	1.31	No	No	0	1	5
310	R:R:S222	R:R:Y219	1.27	No	Yes	0	3	6
311	R:R:D257	R:R:H260	1.26	No	Yes	0	4	4
312	R:R:F106	R:R:L102	1.22	No	No	0	5	5
313	R:R:L337	R:R:R341	1.21	No	No	0	4	3
314	R:R:L300	R:R:Y303	1.17	No	Yes	0	1	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L24	4.9825	4	0	0
2	L:L:Y27	3.9575	4	4	0
3	L:L:R33	4.83	5	1	0
4	L:L:Q34	7.6675	4	0	0
5	L:L:R35	6.362	5	1	0
6	L:L:?36	6.194	5	1	0
7	R:R:Y57	6.998	5	0	7
8	R:R:F78	4.165	4	0	5
9	R:R:M81	4.42	4	5	8
10	R:R:N86	5.28	4	5	8
11	R:R:F88	5.9725	4	0	7
12	R:R:L92	5.085	4	2	9
13	R:R:D96	5.185	4	2	9
14	R:R:L104	5.712	5	0	7
15	R:R:W116	7.185	4	0	8
16	R:R:V126	5.24	5	0	5
17	R:R:Y149	5.082	5	3	8
18	R:R:F186	6.4625	4	6	5
19	R:R:I192	3.89	4	4	2
20	R:R:I194	3.042	5	4	1
21	R:R:W207	4.814	5	6	5
22	R:R:Y219	4.235	4	0	6
23	R:R:Y239	3.76	6	0	9
24	R:R:Y259	6.224	5	7	4
25	R:R:H260	5.78	4	7	4
26	R:R:R263	4.2675	4	7	7
27	R:R:F277	4.105	4	0	9
28	R:R:W281	4.8325	4	0	8
29	R:R:L298	5.9	4	0	1
30	R:R:Y303	5.328	5	0	4
31	R:R:K304	3.004	5	0	4
32	R:R:H311	8.1725	4	1	5
33	R:R:Y325	5.106	5	2	9
34	R:R:Y332	6.31375	8	5	8
35	R:R:F336	4.775	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L24	R:R:I194	15.8134	2.85	Yes	Yes	0	0	1
2	L:L:V31	L:L:Y27	35.0313	3.79	No	Yes	0	0	0
3	L:L:T32	L:L:V31	38.7987	1.59	No	No	0	0	0
4	L:L:T32	R:R:Y110	40.752	8.74	No	No	0	0	5
5	L:L:Q34	R:R:Y110	39.5793	10.15	Yes	No	0	0	5
6	L:L:Q34	R:R:T107	50.5699	12.76	Yes	No	0	0	6
7	R:R:H311	R:R:T107	44.2958	9.58	Yes	No	1	5	6
8	R:R:H311	R:R:Y57	49.126	7.62	Yes	Yes	0	5	7
9	R:R:T308	R:R:Y57	11.9031	2.5	No	Yes	0	3	7
10	L:L:R33	L:L:R35	33.6167	5.33	Yes	Yes	1	0	0
11	L:L:?36	L:L:R35	41.2138	5.13	Yes	Yes	1	0	0
12	L:L:R33	R:R:Y303	48.7338	4.12	Yes	Yes	0	0	4
13	L:L:R33	R:R:E205	18.6426	3.49	Yes	No	1	0	4
14	R:R:E205	R:R:R187	21.9738	6.98	No	No	0	4	6
15	R:R:C203	R:R:R187	17.0997	4.18	No	No	0	9	6
16	R:R:C203	R:R:W116	12.1303	3.92	No	Yes	0	9	8
17	R:R:W116	R:R:Y110	10.8843	10.61	Yes	No	0	8	5
18	L:L:Y27	R:R:I192	11.7822	3.63	Yes	Yes	4	0	2
19	L:L:R35	R:R:Y219	24.7774	9.26	Yes	Yes	0	0	6
20	L:L:R35	R:R:S220	14.3328	3.95	Yes	No	0	0	4
21	R:R:Q130	R:R:V126	26.6061	4.3	No	Yes	0	6	5
22	R:R:L104	R:R:Y57	51.5887	7.03	Yes	Yes	0	7	7
23	R:R:H311	R:R:M315	40.6054	7.88	Yes	No	0	5	7
24	R:R:L104	R:R:M315	40.7593	9.9	Yes	No	0	7	7
25	R:R:I61	R:R:L104	90.8418	7.14	No	Yes	0	6	7
26	R:R:I61	R:R:N100	17.1693	4.25	No	No	0	6	6
27	R:R:C103	R:R:Q130	11.0675	6.1	No	No	0	6	6
28	R:R:C103	R:R:V99	11.1665	5.12	No	No	0	6	7
29	R:R:T318	R:R:V99	11.8701	3.17	No	No	0	9	7
30	R:R:N100	R:R:T318	12.2219	13.16	No	No	0	6	9
31	R:R:I61	R:R:V65	100	1.54	No	No	0	6	6
32	R:R:I66	R:R:V65	99.5016	1.54	No	No	0	4	6
33	R:R:G67	R:R:I66	98.5048	1.76	No	No	0	8	4
34	R:R:G67	R:R:P322	98.0064	2.03	No	No	0	8	9
35	R:R:N68	R:R:P322	97.5226	9.77	No	No	0	9	9
36	R:R:D96	R:R:N68	96.6138	2.69	Yes	No	0	9	9
37	R:R:D96	R:R:L92	94.5798	5.43	Yes	Yes	2	9	9
38	R:R:L92	R:R:T140	93.1433	5.9	Yes	No	0	9	8
39	R:R:N91	R:R:T140	92.0841	2.92	No	No	0	9	8
40	R:R:I169	R:R:N91	71.7668	7.08	No	No	0	7	9
41	R:R:F88	R:R:I169	69.3627	5.02	Yes	No	0	7	7
42	R:R:D147	R:R:F88	54.3739	8.36	No	Yes	0	8	7
43	R:R:D147	R:R:T85	49.1736	4.34	No	No	0	8	8
44	R:R:N86	R:R:T85	47.847	2.92	Yes	No	0	8	8
45	R:R:N86	R:R:Y332	32.0739	8.14	Yes	Yes	5	8	8
46	R:R:N91	R:R:W173	25.7265	6.78	No	No	0	9	9
47	R:R:M81	R:R:N86	13.0795	4.21	Yes	Yes	5	8	8
48	R:R:F336	R:R:Y332	22.7471	3.09	Yes	Yes	0	6	8
49	R:R:F88	R:R:S165	13.8271	2.64	Yes	No	0	7	7
50	R:R:L92	R:R:Y325	86.9022	3.52	Yes	Yes	2	9	9
51	R:R:F106	R:R:V126	12.7936	10.49	No	Yes	0	5	5
52	R:R:C123	R:R:C203	17.9756	7.28	No	No	0	9	9
53	R:R:C123	R:R:Y189	14.7726	4.03	No	No	0	9	5
54	R:R:V136	R:R:W173	19.8629	12.26	No	No	0	7	9
55	R:R:S176	R:R:V136	15.3883	4.85	No	No	0	8	7
56	R:R:F287	R:R:Y303	51.0866	6.19	No	Yes	0	4	4
57	R:R:F287	R:R:F310	50.4636	6.43	No	No	8	4	6
58	R:R:F310	R:R:P283	51.1452	8.67	No	No	0	6	9
59	R:R:L282	R:R:P283	51.1562	3.28	No	No	0	5	9
60	R:R:L282	R:R:Y228	51.1782	10.55	No	No	0	5	8
61	R:R:L232	R:R:Y228	51.2222	3.52	No	No	0	5	8
62	R:R:F277	R:R:L232	51.4494	3.65	Yes	No	0	9	5
63	R:R:F277	R:R:W281	11.9031	5.01	Yes	Yes	0	9	8
64	R:R:F277	R:R:L141	53.8132	4.87	Yes	No	0	9	8
65	R:R:R148	R:R:Y325	45.4612	6.17	No	Yes	2	9	9
66	R:R:R148	R:R:Y239	44.6623	5.14	No	Yes	0	9	9
67	R:R:A145	R:R:Y239	30.3038	4	No	Yes	0	9	9
68	R:R:V273	R:R:Y325	45.5125	6.31	No	Yes	0	8	9
69	R:R:V273	R:R:Y239	44.534	3.79	No	Yes	0	8	9
70	R:R:A145	R:R:S238	23.3994	3.42	No	No	0	9	7
71	R:R:S238	R:R:Y149	21.0833	6.36	No	Yes	0	7	8
72	R:R:W207	R:R:Y219	19.5881	2.89	Yes	Yes	0	5	6
73	R:R:L270	R:R:Y239	52.7394	4.69	No	Yes	0	8	9
74	R:R:L270	R:R:T266	50.5112	1.47	No	No	0	8	8
75	R:R:L246	R:R:T266	48.371	1.47	No	No	0	8	8
76	R:R:L246	R:R:Y259	46.2235	3.52	No	Yes	0	8	4
77	R:R:R263	R:R:Y259	16.3045	3.09	Yes	Yes	7	7	4
78	R:R:K247	R:R:R263	11.7858	3.71	No	Yes	0	6	7
79	R:R:S251	R:R:Y259	11.7162	3.82	No	Yes	0	4	4
80	R:R:H260	R:R:Y259	13.959	8.71	Yes	Yes	7	4	4
81	R:R:F336	R:R:W327	15.326	7.02	Yes	No	0	6	6
82	R:R:M328	R:R:W327	12.3062	3.49	No	No	0	7	6
83	R:R:M269	R:R:M328	10.7817	7.22	No	No	0	8	7
84	L:L:Y27	R:R:I194	19.4048	3.63	Yes	Yes	4	0	1
85	L:L:?36	R:R:H311	44.501	7.61	Yes	Yes	1	0	5
86	L:L:?36	R:R:Q130	23.1429	7.87	Yes	No	0	0	6
87	R:R:L141	R:R:Y325	53.9964	4.69	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K4	R:R:I194	4.36	4	No	Yes	0	1	0	1
L:L:R25	R:R:K301	9.9	0	No	No	0	3	0	1
L:L:H26	R:R:S295	4.18	0	No	No	0	1	0	1
L:L:H26	R:R:L298	10.29	0	No	Yes	0	1	0	1
L:L:H26	R:R:D299	7.56	0	No	No	0	1	0	1
L:L:Y27	R:R:I192	3.63	4	Yes	Yes	0	2	0	1
L:L:Y27	R:R:I194	3.63	4	Yes	Yes	0	1	0	1
L:L:N29	R:R:Y303	10.47	0	No	Yes	0	4	0	1
L:L:L30	R:R:L298	4.15	0	No	Yes	0	1	0	1
L:L:T32	R:R:Y110	8.74	0	No	No	0	5	0	1
L:L:T32	R:R:K304	6.01	0	No	Yes	0	4	0	1
L:L:R33	R:R:E205	3.49	1	Yes	No	0	4	0	1
L:L:R33	R:R:Q288	4.67	1	Yes	No	0	5	0	1
L:L:R33	R:R:V291	6.54	1	Yes	No	0	4	0	1
L:L:R33	R:R:Y303	4.12	1	Yes	Yes	0	4	0	1
L:L:Q34	R:R:T107	12.76	0	Yes	No	0	6	0	1
L:L:Q34	R:R:Y110	10.15	0	Yes	No	0	5	0	1
L:L:Q34	R:R:T111	4.25	0	Yes	No	0	4	0	1
L:L:Q34	R:R:F307	3.51	0	Yes	No	0	4	0	1
L:L:R35	R:R:E205	8.14	1	Yes	No	0	4	0	1
L:L:R35	R:R:Y219	9.26	1	Yes	Yes	0	6	0	1
L:L:R35	R:R:S220	3.95	1	Yes	No	0	4	0	1
L:L:?36	R:R:T107	7.47	1	Yes	No	0	6	0	1
L:L:?36	R:R:Q130	7.87	1	Yes	No	0	6	0	1
L:L:?36	R:R:G131	2.89	1	Yes	No	0	4	0	1
L:L:?36	R:R:H311	7.61	1	Yes	Yes	0	5	0	1
R:R:H311	R:R:Y57	7.62	1	Yes	Yes	5	7	1	2
R:R:C103	R:R:Q130	6.1	0	No	No	6	6	2	1
R:R:H311	R:R:T107	9.58	1	Yes	No	5	6	1	1
R:R:W116	R:R:Y110	10.61	0	Yes	No	8	5	2	1
R:R:K304	R:R:T111	3	0	Yes	No	4	4	1	1
R:R:V126	R:R:W116	4.9	0	Yes	Yes	5	8	2	2
R:R:Q130	R:R:V126	4.3	0	No	Yes	6	5	1	2
R:R:L183	R:R:Y219	3.52	0	No	Yes	5	6	2	1
R:R:E205	R:R:R187	6.98	1	No	No	4	6	1	2
R:R:I192	R:R:S190	3.1	4	Yes	No	2	1	1	2
R:R:I192	R:R:I194	2.94	4	Yes	Yes	2	1	1	1
R:R:I192	R:R:I200	5.89	4	Yes	No	2	3	1	1
R:R:W207	R:R:Y219	2.89	6	Yes	Yes	5	6	2	1
R:R:D292	R:R:S220	7.36	0	No	No	5	4	2	1
R:R:F287	R:R:Y303	6.19	8	No	Yes	4	4	2	1
R:R:V291	R:R:V297	3.21	0	No	No	4	6	1	2
R:R:L298	R:R:V291	4.47	0	Yes	No	1	4	1	1
R:R:L298	R:R:Y303	4.69	0	Yes	Yes	1	4	1	1
R:R:H311	R:R:M315	7.88	1	Yes	No	5	7	1	2
L:L:L24	R:R:I194	2.85	0	Yes	Yes	0	1	0	1
L:L:L24	R:R:L40	2.77	0	Yes	No	0	7	0	1
R:R:D42	R:R:K304	2.77	0	No	Yes	3	4	2	1
R:R:E302	R:R:K301	2.7	0	No	No	3	3	2	1
R:R:G114	R:R:K304	1.74	0	No	Yes	5	4	2	1
L:L:V31	R:R:A202	1.7	0	No	No	0	4	0	1
R:R:K304	R:R:T44	1.5	0	Yes	No	4	4	1	2
R:R:L289	R:R:S220	1.5	0	No	No	5	4	2	1
L:L:L28	R:R:I194	1.43	0	No	Yes	0	1	0	1
L:L:L28	R:R:I200	1.43	0	No	No	0	3	0	1
R:R:D299	R:R:Q296	1.31	0	No	No	1	5	1	2
R:R:S222	R:R:Y219	1.27	0	No	Yes	3	6	2	1
R:R:L300	R:R:Y303	1.17	0	No	Yes	1	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YON_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	298
Number of Links	314
Number of Hubs	35
Number of Links mediated by Hubs	133
Number of Communities	9
Number of Nodes involved in Communities	36
Number of Links involved in Communities	40

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	68001
Length Of Smallest Path	3
Average Path Length	17.5842
Length of Longest Path	38
Minimum Path Strength	1.4
Average Path Strength	5.15311
Maximum Path Strength	11.1733
Minimum Path Correlation	0.7
Average Path Correlation	0.934953
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	48.5552
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.8601
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular function activator activity • signaling receptor binding • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • G protein-coupled receptor binding • neuropeptide Y receptor binding • neuropeptide receptor binding • epithelium development • digestive system development • cellular developmental process • intestinal epithelial cell differentiation • tube development • tissue development • digestive tract development • epithelial cell differentiation • cell differentiation • columnar/cuboidal epithelial cell differentiation • neuropeptide signaling pathway • behavior • feeding behavior • molecular transducer activity • signaling receptor activity • peptide receptor activity • neuropeptide Y receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • transporter regulator activity • peptide YY receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • locomotory behavior • nitric oxide mediated signal transduction • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • positive regulation of biological process • cell-substrate adhesion • cell adhesion • positive regulation of cell-substrate adhesion • positive regulation of cellular process • regulation of localization • regulation of transport • transport • secretion • negative regulation of biological process • negative regulation of transport • establishment of localization • regulation of secretion • localization • negative regulation of secretion • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, non-REM sleep • regulation of circadian rhythm • regulation of behavior • circadian sleep/wake cycle, non-REM sleep • regulation of multicellular organismal process • sleep • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • positive regulation of circadian sleep/wake cycle, non-REM sleep • circadian rhythm • circadian behavior • positive regulation of behavior • positive regulation of circadian rhythm • positive regulation of multicellular organismal process • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of peptide secretion • nitrogen compound transport • regulation of peptide secretion • regulation of peptide transport • peptide transport • peptide secretion • positive regulation of secretion • positive regulation of transport • amide transport • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • secretion by cell • regulation of secretion by cell • catecholamine transport • signal release • positive regulation of catecholamine secretion • export from cell • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • heart development • cardiac chamber morphogenesis • heart morphogenesis • circulatory system development • anatomical structure morphogenesis • cardiac ventricle morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac left ventricle morphogenesis • cardiac ventricle development • negative regulation of signaling • negative regulation of intracellular signal transduction • regulation of signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • regulation of intracellular signal transduction • negative regulation of cellular process • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • regulation of cell communication • negative regulation of nervous system process • regulation of system process • regulation of nervous system process • negative regulation of multicellular organismal process • synaptic signaling via neuropeptide • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • trans-synaptic signaling • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • positive regulation of smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • modulation of excitatory postsynaptic potential • cell surface receptor signaling pathway • negative regulation of excitatory postsynaptic potential • excitatory postsynaptic potential • regulation of membrane potential • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • negative regulation of feeding behavior • negative regulation of behavior • regulation of feeding behavior • outflow tract morphogenesis • presynapse • glutamatergic synapse
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYC
PDB Residues	L:L:?36
Environment Details	Open EMBL-EBI Page
Code	TYC
Name	L-tyrosinamide
Synonyms	L-tyrosinamide (2S)-2-amino-3-(4-hydroxyphenyl)propanamide L-Tyrosine amide Tyrosinamide Tyrosine amide
Identifier
Formula	C9 H12 N2 O2
Molecular Weight	180.204
SMILES
PubChem	151243
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49146
Sequence	>7YON_nogp_Chain_R L I D S T K L I E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F K S M R T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G E W K M G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R Y R C I V Y H L E S K I S K R I S F L I I G L A W G I S A L L A S P L A I F R E Y S L I E I I P D F E I V A C T E K W P G E E K S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G A A N D H Y H Q R R Q K T T K M L V C V V V V F A V C W L P L H A F Q L A V D I D S Q V L D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N Y R K A F L S A F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	doi.org/10.1038/s41586-020-1954-0
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	7WIH	C	Aminoacid	Metabotropic Glutamate	mGlu3; mGlu3	Homo sapiens	LY2794193	-	-	3.68	2022-03-16	doi.org/10.1038/s41422-022-00623-z
	7YON	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-	Gi1/β1/γ2	2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YON (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-		2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7DDZ	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	JNJ-31020028	-	-	2.8	2021-01-27	doi.org/10.1038/s41467-021-21030-9
	7X9B	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	7X9B (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	8K6N	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-	Gi2/β1/γ1	3.2	2024-07-31	doi.org/10.1002/mco2.565
	8K6N (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-		3.2	2024-07-31	doi.org/10.1002/mco2.565
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3

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