psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I41	R:R:K301	5.82	No	No	0	3	3
2	R:R:D42	R:R:T44	5.78	No	No	0	3	4
3	R:R:D42	R:R:K45	8.3	No	No	0	3	3
4	R:R:E302	R:R:S43	8.62	No	No	0	3	5
5	R:R:K304	R:R:T44	10.51	No	No	0	4	4
6	R:R:Q50	R:R:V51	4.3	No	No	0	4	6
7	R:R:I54	R:R:Q50	6.86	No	No	0	6	4
8	R:R:L55	R:R:V52	4.47	No	No	0	6	5
9	R:R:L53	R:R:T308	4.42	No	No	0	5	3
10	R:R:L104	R:R:Y57	7.03	No	Yes	0	7	7
11	R:R:L108	R:R:Y57	12.89	No	Yes	0	6	7
12	R:R:T308	R:R:Y57	4.99	No	Yes	0	3	7
13	R:R:H311	R:R:Y57	5.44	No	Yes	0	5	7
14	R:R:I312	R:R:Y57	13.3	No	Yes	0	5	7
15	R:R:I61	R:R:L104	7.14	No	No	0	6	7
16	R:R:F319	R:R:L63	4.87	No	No	0	7	6
17	R:R:G64	R:R:N100	5.09	No	No	0	7	6
18	R:R:L97	R:R:V65	4.47	No	No	0	7	6
19	R:R:D96	R:R:N68	4.04	No	Yes	3	9	9
20	R:R:L97	R:R:N68	10.98	No	Yes	0	7	9
21	R:R:N100	R:R:N68	4.09	No	Yes	0	6	9
22	R:R:N68	R:R:P322	8.15	Yes	No	3	9	9
23	R:R:A93	R:R:V71	3.39	No	No	0	9	9
24	R:R:H73	R:R:K77	3.93	No	No	0	4	5
25	R:R:F336	R:R:V74	5.24	No	No	0	6	7
26	R:R:A90	R:R:V75	5.09	No	No	0	6	7
27	R:R:I76	R:R:R82	6.26	No	No	0	3	6
28	R:R:M81	R:R:N86	5.61	No	Yes	0	8	8
29	R:R:A335	R:R:M81	3.22	No	No	0	6	8
30	R:R:F87	R:R:R82	8.55	No	No	0	5	6
31	R:R:N86	R:R:T83	5.85	Yes	No	0	8	7
32	R:R:F88	R:R:V84	5.24	Yes	No	0	7	6
33	R:R:I160	R:R:V84	9.22	No	No	0	5	6
34	R:R:S165	R:R:V84	6.46	No	No	0	7	6
35	R:R:D147	R:R:T85	5.78	No	No	0	8	8
36	R:R:N86	R:R:Y332	13.96	Yes	Yes	0	8	8
37	R:R:F166	R:R:F87	5.36	No	No	0	4	5
38	R:R:F88	R:R:V143	7.87	Yes	No	0	7	7
39	R:R:F88	R:R:I144	5.02	Yes	No	0	7	9
40	R:R:D147	R:R:F88	3.58	No	Yes	0	8	7
41	R:R:F88	R:R:I169	5.02	Yes	No	0	7	7
42	R:R:I89	R:R:Y325	8.46	No	Yes	0	8	9
43	R:R:I89	R:R:Y332	7.25	No	Yes	0	8	8
44	R:R:N91	R:R:T140	8.77	No	No	0	9	8
45	R:R:I169	R:R:N91	5.66	No	No	0	7	9
46	R:R:N91	R:R:W173	10.17	No	Yes	0	9	9
47	R:R:L92	R:R:T140	4.42	No	No	0	9	8
48	R:R:L141	R:R:L92	5.54	No	No	0	8	9
49	R:R:D96	R:R:T318	5.78	No	No	0	9	9
50	R:R:D96	R:R:P322	4.83	No	No	3	9	9
51	R:R:C103	R:R:V99	6.83	No	No	0	6	7
52	R:R:N100	R:R:T318	10.24	No	No	0	6	9
53	R:R:L102	R:R:T101	4.42	No	No	0	5	5
54	R:R:A129	R:R:L102	4.73	No	No	0	5	5
55	R:R:C103	R:R:Q130	4.58	No	No	0	6	6
56	R:R:C103	R:R:M315	3.24	No	No	0	6	7
57	R:R:F106	R:R:W116	7.02	No	Yes	0	5	8
58	R:R:F106	R:R:V126	9.18	No	No	0	5	5
59	L:L:Q34	R:R:T107	12.76	Yes	No	0	0	6
60	R:R:L108	R:R:L112	4.15	No	No	0	6	4
61	R:R:W116	R:R:Y110	8.68	Yes	Yes	0	8	5
62	R:R:A202	R:R:Y110	4	No	Yes	0	4	5
63	L:L:T32	R:R:Y110	3.75	No	Yes	0	0	5
64	L:L:Q34	R:R:Y110	5.64	Yes	Yes	0	0	5
65	R:R:E115	R:R:K117	21.6	No	No	0	5	3
66	R:R:E115	R:R:I200	5.47	No	No	0	5	3
67	R:R:M118	R:R:W116	10.47	No	Yes	5	7	8
68	R:R:L122	R:R:W116	4.56	No	Yes	5	6	8
69	R:R:C123	R:R:W116	16.98	No	Yes	0	9	8
70	R:R:L122	R:R:M118	4.24	No	No	5	6	7
71	R:R:G119	R:R:P120	4.06	No	No	0	8	3
72	R:R:P120	R:R:Y189	16.69	No	No	0	3	5
73	R:R:C123	R:R:C203	7.28	No	No	0	9	9
74	R:R:H124	R:R:R187	4.51	No	No	0	7	6
75	R:R:P127	R:R:V126	3.53	No	No	0	5	5
76	R:R:L183	R:R:P127	3.28	Yes	No	0	5	5
77	R:R:P127	R:R:R187	8.65	No	No	0	5	6
78	R:R:A184	R:R:Y128	4	No	No	0	5	6
79	L:L:Q34	R:R:Q130	3.84	Yes	No	4	0	6
80	L:L:?36	R:R:Q130	15.75	Yes	No	4	0	6
81	R:R:L132	R:R:W173	6.83	No	Yes	0	5	9
82	R:R:V134	R:R:W281	7.36	No	Yes	0	7	8
83	R:R:I139	R:R:Q135	4.12	No	No	0	5	6
84	R:R:L179	R:R:Q135	13.31	No	No	0	5	6
85	R:R:L227	R:R:Q135	6.65	No	No	0	6	6
86	R:R:V136	R:R:W173	20.84	No	Yes	0	7	9
87	R:R:S176	R:R:V136	3.23	No	No	0	8	7
88	R:R:P231	R:R:T138	5.25	Yes	No	1	9	8
89	R:R:F277	R:R:T138	3.89	Yes	No	1	9	8
90	R:R:L141	R:R:N321	4.12	No	No	0	8	9
91	R:R:L141	R:R:Y325	3.52	No	Yes	0	8	9
92	R:R:P231	R:R:T142	3.5	Yes	No	0	9	7
93	R:R:I234	R:R:T142	6.08	No	No	0	6	7
94	R:R:I144	R:R:R148	5.01	No	No	0	9	9
95	R:R:A145	R:R:I235	3.25	No	No	0	9	8
96	R:R:R148	R:R:Y239	8.23	No	Yes	0	9	9
97	R:R:R148	R:R:Y325	6.17	No	Yes	0	9	9
98	R:R:H149	R:R:V153	8.3	Yes	No	0	8	7
99	R:R:H149	R:R:Y154	3.27	Yes	No	0	8	7
100	R:R:H149	R:R:S238	5.58	Yes	No	0	8	7
101	R:R:H149	R:R:R241	3.39	Yes	No	0	8	4
102	R:R:E157	R:R:R150	4.65	No	No	0	4	4
103	R:R:I160	R:R:R150	6.26	No	No	0	5	4
104	R:R:I152	R:R:I242	10.3	No	No	0	8	8
105	R:R:H155	R:R:K245	7.86	No	No	0	8	5
106	R:R:I164	R:R:S161	4.64	No	No	0	5	6
107	R:R:F166	R:R:S165	5.28	No	No	0	4	7
108	R:R:P182	R:R:S181	5.34	No	No	0	8	4
109	R:R:P182	R:R:Y219	5.56	No	Yes	0	8	6
110	R:R:E205	R:R:L183	3.98	Yes	Yes	0	4	5
111	R:R:L183	R:R:Y219	4.69	Yes	Yes	0	5	6
112	R:R:F186	R:R:I185	3.77	No	No	0	5	4
113	R:R:F186	R:R:W207	16.04	No	Yes	0	5	5
114	R:R:E205	R:R:R187	10.47	Yes	No	0	4	6
115	R:R:E188	R:R:T204	8.47	No	No	0	4	4
116	R:R:E188	R:R:K206	8.1	No	No	0	4	3
117	R:R:V201	R:R:Y189	7.57	No	No	0	4	5
118	R:R:E193	R:R:E199	16.49	No	No	0	2	4
119	R:R:I194	R:R:P196	5.08	No	No	0	1	3
120	R:R:F198	R:R:I194	3.77	No	No	0	1	1
121	L:L:P5	R:R:I194	3.39	No	No	0	0	1
122	R:R:I195	R:R:P196	3.39	No	No	0	2	3
123	L:L:P8	R:R:I195	13.55	Yes	No	0	0	2
124	R:R:D197	R:R:E199	3.9	No	No	0	4	4
125	R:R:F198	R:R:I200	6.28	No	No	0	1	3
126	R:R:E205	R:R:W207	5.45	Yes	Yes	0	4	5
127	L:L:R35	R:R:E205	5.82	Yes	Yes	0	0	4
128	R:R:S213	R:R:W207	4.94	No	Yes	0	2	5
129	R:R:G216	R:R:W207	9.85	No	Yes	0	4	5
130	R:R:W207	R:R:Y219	3.86	Yes	Yes	0	5	6
131	R:R:E210	R:R:G209	3.27	No	No	0	1	4
132	L:L:Y1	R:R:E211	5.61	No	No	0	0	2
133	R:R:I214	R:R:K212	10.18	No	No	0	1	3
134	R:R:D292	R:R:T217	7.23	No	No	0	5	3
135	R:R:I293	R:R:T217	6.08	No	No	0	4	3
136	L:L:R35	R:R:Y219	5.14	Yes	Yes	0	0	6
137	R:R:D292	R:R:S220	8.83	No	No	0	5	4
138	R:R:H285	R:R:L227	3.86	Yes	No	0	7	6
139	R:R:L232	R:R:Y228	4.69	Yes	No	0	5	8
140	R:R:L282	R:R:Y228	12.89	No	No	0	5	8
141	R:R:F277	R:R:P231	4.33	Yes	Yes	1	9	9
142	R:R:G233	R:R:L232	3.42	No	Yes	0	3	5
143	R:R:F277	R:R:L232	3.65	Yes	Yes	0	9	5
144	R:R:I235	R:R:Y239	4.84	No	Yes	0	8	9
145	R:R:F237	R:R:R241	6.41	No	No	0	4	4
146	R:R:S238	R:R:Y239	3.82	No	Yes	0	7	9
147	R:R:L270	R:R:Y239	15.24	No	Yes	0	8	9
148	R:R:R241	R:R:S244	3.95	No	No	0	4	4
149	R:R:T267	R:R:W243	4.85	No	No	0	6	5
150	R:R:L246	R:R:R263	3.64	No	Yes	0	8	7
151	R:R:K247	R:R:R263	13.61	No	Yes	0	6	7
152	R:R:H249	R:R:Y259	5.44	No	No	0	6	4
153	R:R:D257	R:R:V250	4.38	Yes	No	0	4	4
154	R:R:P252	R:R:S251	5.34	No	Yes	0	4	4
155	R:R:N256	R:R:S251	8.94	No	Yes	0	4	4
156	R:R:D257	R:R:S251	8.83	Yes	Yes	0	4	4
157	R:R:N256	R:R:Y259	5.81	No	No	0	4	4
158	R:R:D257	R:R:Y259	3.45	Yes	No	0	4	4
159	R:R:H260	R:R:R263	12.41	No	Yes	0	4	7
160	R:R:Q264	R:R:R263	3.5	No	Yes	0	5	7
161	R:R:Q264	R:R:T267	4.25	No	No	0	5	6
162	R:R:K265	R:R:K268	4.31	No	No	0	8	6
163	R:R:M269	R:R:M328	5.78	No	No	0	8	7
164	R:R:F277	R:R:W281	8.02	Yes	Yes	1	9	8
165	R:R:S280	R:R:W281	8.65	No	Yes	1	8	8
166	R:R:S280	R:R:S317	4.89	No	No	1	8	9
167	R:R:H285	R:R:W281	9.52	Yes	Yes	0	7	8
168	R:R:S317	R:R:W281	6.18	No	Yes	1	9	8
169	R:R:L282	R:R:P283	3.28	No	No	0	5	9
170	R:R:F310	R:R:P283	4.33	No	No	0	6	9
171	R:R:H285	R:R:L284	3.86	Yes	No	0	7	6
172	R:R:A314	R:R:L284	4.73	No	No	0	7	6
173	L:L:?36	R:R:H285	4.35	Yes	Yes	0	0	7
174	R:R:F287	R:R:Q288	3.51	Yes	No	0	4	5
175	R:R:F287	R:R:V291	7.87	Yes	Yes	2	4	4
176	R:R:F287	R:R:Y303	7.22	Yes	Yes	2	4	4
177	R:R:F287	R:R:I306	6.28	Yes	No	0	4	5
178	R:R:F287	R:R:F307	8.57	Yes	No	0	4	4
179	R:R:F287	R:R:F310	7.5	Yes	No	0	4	6
180	L:L:R33	R:R:Q288	12.85	No	No	0	0	5
181	L:L:R35	R:R:Q288	5.84	Yes	No	0	0	5
182	R:R:I293	R:R:L289	4.28	No	No	0	4	5
183	R:R:A290	R:R:V297	5.09	No	No	0	5	6
184	R:R:V291	R:R:Y303	8.83	Yes	Yes	2	4	4
185	L:L:R33	R:R:V291	11.77	No	Yes	2	0	4
186	R:R:D294	R:R:V297	4.38	No	No	0	2	6
187	R:R:Q296	R:R:S295	4.33	No	No	0	5	1
188	R:R:D299	R:R:Q296	9.14	No	No	0	1	5
189	L:L:H26	R:R:Q296	7.42	No	No	0	0	5
190	R:R:L298	R:R:Y303	3.52	No	Yes	0	1	4
191	L:L:H26	R:R:L298	15.43	No	No	0	0	1
192	L:L:R25	R:R:D299	10.72	No	No	0	0	1
193	R:R:E302	R:R:K301	5.4	No	No	0	3	3
194	L:L:R25	R:R:K301	3.71	No	No	0	0	3
195	R:R:E302	R:R:L305	3.98	No	No	0	3	1
196	L:L:N29	R:R:Y303	15.12	No	Yes	0	0	4
197	L:L:R33	R:R:Y303	4.12	No	Yes	2	0	4
198	L:L:N29	R:R:K304	5.6	No	No	0	0	4
199	L:L:Q34	R:R:F307	5.86	Yes	No	0	0	4
200	R:R:H311	R:R:M315	11.82	No	No	0	5	7
201	L:L:?36	R:R:H311	7.61	Yes	No	0	0	5
202	R:R:M315	R:R:T318	6.02	No	No	0	7	9
203	R:R:N321	R:R:S317	4.47	No	No	0	9	9
204	R:R:L324	R:R:Y325	8.21	No	Yes	0	8	9
205	R:R:G326	R:R:Y332	4.35	No	Yes	0	7	8
206	R:R:M328	R:R:W327	8.14	No	No	0	7	6
207	R:R:R333	R:R:W327	12	No	No	0	8	6
208	R:R:N329	R:R:N331	4.09	No	No	0	8	6
209	R:R:F336	R:R:F340	6.43	No	No	0	6	5
210	R:R:L337	R:R:R341	3.64	No	No	0	4	3
211	L:L:K4	L:L:Y1	8.36	No	No	0	0	0
212	L:L:K4	L:L:S3	10.71	No	No	0	0	0
213	L:L:D6	L:L:K4	5.53	No	No	0	0	0
214	L:L:P5	L:L:Y27	5.56	No	No	0	0	0
215	L:L:D16	L:L:N7	6.73	No	No	0	0	0
216	L:L:A12	L:L:D16	4.63	No	No	0	0	0
217	L:L:E15	L:L:P13	4.72	No	No	0	0	0
218	L:L:M17	L:L:Y21	3.59	No	No	0	0	0
219	L:L:L24	L:L:Y20	3.52	No	No	0	0	0
220	L:L:I31	L:L:Y27	3.63	Yes	No	0	0	0
221	L:L:I31	L:L:T32	4.56	Yes	No	0	0	0
222	L:L:?36	L:L:Q34	7.87	Yes	Yes	4	0	0
223	L:L:?36	L:L:R35	10.27	Yes	Yes	0	0	0
224	R:R:V271	R:R:V274	3.21	No	No	0	6	8
225	R:R:V291	R:R:V297	3.21	Yes	No	0	4	6
226	R:R:A177	R:R:L132	3.15	No	No	0	4	5
227	R:R:I192	R:R:S190	3.1	No	No	0	2	1
228	R:R:I72	R:R:V94	3.07	No	No	0	7	6
229	R:R:I168	R:R:V143	3.07	No	No	0	5	7
230	R:R:I235	R:R:V274	3.07	No	No	0	8	8
231	R:R:K117	R:R:V201	3.04	No	No	0	3	4
232	R:R:F336	R:R:G326	3.01	No	No	0	6	7
233	R:R:L92	R:R:S137	3	No	No	0	9	9
234	R:R:L46	R:R:V49	2.98	No	No	0	2	4
235	R:R:L53	R:R:V49	2.98	No	No	0	5	4
236	R:R:L324	R:R:V273	2.98	No	No	0	8	8
237	R:R:N321	R:R:V276	2.96	No	No	0	9	6
238	R:R:L97	R:R:T101	2.95	No	No	0	7	5
239	R:R:I312	R:R:I60	2.94	No	No	0	5	7
240	R:R:I160	R:R:I164	2.94	No	No	0	5	5
241	R:R:I54	R:R:L108	2.85	No	No	0	6	6
242	R:R:I234	R:R:L146	2.85	No	No	0	6	6
243	R:R:I168	R:R:L167	2.85	No	No	0	5	3
244	R:R:I226	R:R:L230	2.85	No	No	0	4	6
245	R:R:I242	R:R:L246	2.85	No	No	0	8	8
246	R:R:C316	R:R:F319	2.79	No	No	0	5	7
247	L:L:P8	L:L:Y20	2.78	Yes	No	0	0	0
248	R:R:A335	R:R:F78	2.77	No	No	0	6	5
249	R:R:A339	R:R:F78	2.77	No	No	0	4	5
250	R:R:L224	R:R:L289	2.77	No	No	0	5	5
251	R:R:E48	R:R:I47	2.73	No	No	0	2	2
252	R:R:N331	R:R:N86	2.72	No	Yes	0	6	8
253	L:L:E10	L:L:M17	2.71	No	No	0	0	0
254	R:R:P208	R:R:W207	2.7	No	Yes	0	4	5
255	L:L:D6	L:L:N7	2.69	No	No	0	0	0
256	R:R:A177	R:R:Y128	2.67	No	No	0	4	6
257	R:R:A180	R:R:Y128	2.67	No	No	0	7	6
258	R:R:F78	R:R:S338	2.64	No	No	0	5	4
259	L:L:R25	L:L:S22	2.64	No	No	0	0	0
260	L:L:D16	L:L:E15	2.6	No	No	0	0	0
261	R:R:H285	R:R:L224	2.57	Yes	No	0	7	5
262	L:L:H26	L:L:L30	2.57	No	No	0	0	0
263	R:R:H258	R:R:N256	2.55	No	No	0	4	4
264	L:L:?36	R:R:S223	2.54	Yes	No	0	0	5
265	R:R:V75	R:R:Y332	2.52	No	Yes	0	7	8
266	R:R:D257	R:R:H260	2.52	Yes	No	0	4	4
267	R:R:F166	R:R:K162	2.48	No	No	0	4	1
268	R:R:I242	R:R:Y239	2.42	No	Yes	0	8	9
269	L:L:Y21	R:R:L40	2.34	No	No	0	0	7
270	L:L:L24	L:L:Y21	2.34	No	No	0	0	0
271	L:L:G9	L:L:P8	2.03	No	Yes	0	0	0
272	R:R:A254	R:R:G253	1.95	No	No	0	3	4
273	R:R:W207	R:R:Y215	1.93	Yes	No	0	5	3
274	R:R:G233	R:R:S236	1.86	No	No	0	3	5
275	R:R:G253	R:R:S251	1.86	No	Yes	0	4	4
276	R:R:P322	R:R:V71	1.77	No	No	0	9	9
277	R:R:G67	R:R:I66	1.76	No	No	0	8	4
278	R:R:G170	R:R:I169	1.76	No	No	0	4	7
279	R:R:A56	R:R:S59	1.71	No	No	0	5	5
280	R:R:G64	R:R:L63	1.71	No	No	0	7	6
281	R:R:A95	R:R:S137	1.71	No	No	0	8	9
282	R:R:G131	R:R:L183	1.71	No	Yes	0	4	5
283	R:R:A133	R:R:V99	1.7	No	No	0	7	7
284	R:R:A320	R:R:V276	1.7	No	No	0	6	6
285	R:R:I61	R:R:P105	1.69	No	No	0	6	8
286	R:R:I313	R:R:P283	1.69	No	No	0	7	9
287	R:R:C151	R:R:I152	1.64	No	No	0	8	8
288	R:R:L230	R:R:P231	1.64	No	Yes	0	6	9
289	L:L:N7	L:L:P8	1.63	No	Yes	0	0	0
290	R:R:A172	R:R:I139	1.62	No	No	0	7	5
291	R:R:A339	R:R:K77	1.61	No	No	0	4	5
292	R:R:D197	R:R:P196	1.61	No	No	0	4	3
293	R:R:C58	R:R:L55	1.59	No	No	0	4	6
294	R:R:T217	R:R:V218	1.59	No	No	0	3	4
295	R:R:A133	R:R:L98	1.58	No	No	0	7	7
296	R:R:A278	R:R:L232	1.58	No	Yes	0	5	5
297	R:R:A286	R:R:L282	1.58	No	No	0	6	5
298	R:R:I60	R:R:S59	1.55	No	No	0	7	5
299	R:R:I47	R:R:V51	1.54	No	No	0	2	6
300	R:R:I214	R:R:V218	1.54	No	No	0	1	4
301	L:L:A12	L:L:D11	1.54	No	No	0	0	0
302	L:L:I31	R:R:T204	1.52	Yes	No	0	0	4
303	R:R:M269	R:R:V273	1.52	No	No	0	8	8
304	R:R:K159	R:R:T83	1.5	No	No	0	5	7
305	R:R:K304	R:R:T111	1.5	No	No	0	4	4
306	R:R:L98	R:R:V94	1.49	No	No	0	7	6
307	R:R:L191	R:R:V201	1.49	No	No	0	3	4
308	R:R:N248	R:R:S244	1.49	No	No	0	4	4
309	L:L:I31	R:R:I192	1.47	Yes	No	0	0	2
310	R:R:I175	R:R:L179	1.43	No	No	0	4	5
311	R:R:I226	R:R:L225	1.43	No	No	0	4	5
312	L:L:I28	L:L:L24	1.43	No	No	0	0	0
313	R:R:G174	R:R:W173	1.41	No	Yes	0	4	9
314	L:L:P2	L:L:Y1	1.39	No	No	0	0	0
315	R:R:L221	R:R:L289	1.38	No	No	0	4	5
316	R:R:D299	R:R:L300	1.36	No	No	0	1	1
317	L:L:R19	L:L:S22	1.32	No	No	0	0	0
318	R:R:F310	R:R:V309	1.31	No	No	0	6	6
319	R:R:K79	R:R:R82	1.24	No	No	0	6	6
320	R:R:F340	R:R:L70	1.22	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y57	8.73	5	0	7
2	R:R:N68	6.815	4	3	9
3	R:R:N86	7.035	4	0	8
4	R:R:F88	5.346	5	0	7
5	R:R:Y110	5.5175	4	0	5
6	R:R:W116	9.542	5	5	8
7	R:R:H149	5.135	4	0	8
8	R:R:W173	9.8125	4	0	9
9	R:R:L183	3.415	4	0	5
10	R:R:E205	6.43	4	0	4
11	R:R:W207	6.39571	7	0	5
12	R:R:Y219	4.8125	4	0	6
13	R:R:P231	3.68	4	1	9
14	R:R:L232	3.335	4	0	5
15	R:R:Y239	6.91	5	0	9
16	R:R:S251	6.2425	4	0	4
17	R:R:D257	4.795	4	0	4
18	R:R:R263	8.29	4	0	7
19	R:R:F277	4.9725	4	1	9
20	R:R:W281	7.946	5	1	8
21	R:R:H285	4.832	5	0	7
22	R:R:F287	6.825	6	2	4
23	R:R:V291	7.92	4	2	4
24	R:R:Y303	7.762	5	2	4
25	R:R:Y325	6.59	4	0	9
26	R:R:Y332	7.02	4	0	8
27	L:L:P8	4.9975	4	0	0
28	L:L:I31	2.795	4	0	0
29	L:L:Q34	7.194	5	4	0
30	L:L:R35	6.7675	4	0	0
31	L:L:?36	8.065	6	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N29	R:R:K304	11.5548	5.6	No	No	0	0	4
2	L:L:N29	R:R:Y303	13.8476	15.12	No	Yes	0	0	4
3	R:R:L298	R:R:Y303	34.2026	3.52	No	Yes	0	1	4
4	L:L:H26	R:R:L298	31.9659	15.43	No	No	0	0	1
5	L:L:H26	R:R:Q296	27.4738	7.42	No	No	0	0	5
6	R:R:D299	R:R:Q296	22.9567	9.14	No	No	0	1	5
7	L:L:R25	R:R:D299	18.4146	10.72	No	No	0	0	1
8	L:L:R25	R:R:K301	11.5548	3.71	No	No	0	0	3
9	R:R:F287	R:R:Y303	34.8515	7.22	Yes	Yes	2	4	4
10	R:R:F287	R:R:Q288	21.6215	3.51	Yes	No	0	4	5
11	L:L:R35	R:R:Q288	40.1329	5.84	Yes	No	0	0	5
12	L:L:?36	L:L:R35	56.8474	10.27	Yes	Yes	0	0	0
13	L:L:?36	R:R:H311	44.3256	7.61	Yes	No	0	0	5
14	R:R:H311	R:R:Y57	21.3938	5.44	No	Yes	0	5	7
15	L:L:R33	R:R:Y303	14.9488	4.12	No	Yes	2	0	4
16	L:L:R33	R:R:Q288	18.4365	12.85	No	No	0	0	5
17	R:R:F287	R:R:F307	27.8575	8.57	Yes	No	0	4	4
18	L:L:Q34	R:R:F307	28.575	5.86	Yes	No	0	0	4
19	L:L:?36	L:L:Q34	55.4592	7.87	Yes	Yes	4	0	0
20	R:R:N100	R:R:T318	15.4542	10.24	No	No	0	6	9
21	R:R:M315	R:R:T318	30.8117	6.02	No	No	0	7	9
22	R:R:C103	R:R:Q130	11.5766	4.58	No	No	0	6	6
23	R:R:H311	R:R:M315	25.4835	11.82	No	No	0	5	7
24	R:R:D96	R:R:T318	14.0504	5.78	No	No	0	9	9
25	R:R:L97	R:R:N68	14.1908	10.98	No	Yes	0	7	9
26	R:R:N86	R:R:Y332	13.5981	13.96	Yes	Yes	0	8	8
27	R:R:I89	R:R:Y332	22.1893	7.25	No	Yes	0	8	8
28	R:R:I89	R:R:Y325	23.2375	8.46	No	Yes	0	8	9
29	R:R:L141	R:R:Y325	74.5602	3.52	No	Yes	0	8	9
30	R:R:L141	R:R:N321	87.1319	4.12	No	No	0	8	9
31	R:R:N321	R:R:S317	88.7135	4.47	No	No	0	9	9
32	R:R:S317	R:R:W281	88.8976	6.18	No	Yes	1	9	8
33	R:R:H285	R:R:W281	93.7765	9.52	Yes	Yes	0	7	8
34	L:L:?36	R:R:H285	100	4.35	Yes	Yes	0	0	7
35	R:R:R148	R:R:Y325	54.4734	6.17	No	Yes	0	9	9
36	R:R:I144	R:R:R148	22.7789	5.01	No	No	0	9	9
37	R:R:F88	R:R:I144	21.8087	5.02	Yes	No	0	7	9
38	R:R:F88	R:R:V84	14.718	5.24	Yes	No	0	7	6
39	R:R:N91	R:R:T140	11.5548	8.77	No	No	0	9	8
40	R:R:L92	R:R:T140	12.525	4.42	No	No	0	9	8
41	R:R:L141	R:R:L92	15.4168	5.54	No	No	0	8	9
42	R:R:N91	R:R:W173	10.3007	10.17	No	Yes	0	9	9
43	L:L:Q34	R:R:Y110	47.9005	5.64	Yes	Yes	0	0	5
44	L:L:R35	R:R:E205	14.9208	5.82	Yes	Yes	0	0	4
45	L:L:R35	R:R:Y219	13.3579	5.14	Yes	Yes	0	0	6
46	L:L:T32	R:R:Y110	42.092	3.75	No	Yes	0	0	5
47	L:L:P5	R:R:I194	34.6893	3.39	No	No	0	0	1
48	L:L:P5	L:L:Y27	35.5316	5.56	No	No	0	0	0
49	L:L:I31	L:L:Y27	36.3832	3.63	Yes	No	0	0	0
50	L:L:I31	L:L:T32	41.2934	4.56	Yes	No	0	0	0
51	R:R:F277	R:R:W281	16.6396	8.02	Yes	Yes	1	9	8
52	R:R:R148	R:R:Y239	38.1489	8.23	No	Yes	0	9	9
53	R:R:I242	R:R:Y239	24.2763	2.42	No	Yes	0	8	9
54	R:R:I194	R:R:P196	25.861	5.08	No	No	0	1	3
55	R:R:I195	R:R:P196	22.155	3.39	No	No	0	2	3
56	L:L:P8	R:R:I195	21.2129	13.55	Yes	No	0	0	2
57	L:L:N7	L:L:P8	12.4563	1.63	No	Yes	0	0	0
58	R:R:L224	R:R:L289	10.3569	2.77	No	No	0	5	5
59	R:R:H285	R:R:L224	11.4768	2.57	Yes	No	0	7	5
60	R:R:I242	R:R:L246	21.1349	2.85	No	No	0	8	8
61	R:R:L246	R:R:R263	20.0618	3.64	No	Yes	0	8	7
62	R:R:D257	R:R:H260	13.5918	2.52	Yes	No	0	4	4
63	R:R:H260	R:R:R263	14.6868	12.41	No	Yes	0	4	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I41	R:R:K301	5.82	0	No	No	3	3	2	1
R:R:K304	R:R:T44	10.51	0	No	No	4	4	1	2
R:R:H311	R:R:Y57	5.44	0	No	Yes	5	7	1	2
R:R:C103	R:R:Q130	4.58	0	No	No	6	6	2	1
R:R:C103	R:R:M315	3.24	0	No	No	6	7	2	2
L:L:Q34	R:R:T107	12.76	4	Yes	No	0	6	0	1
R:R:W116	R:R:Y110	8.68	5	Yes	Yes	8	5	2	1
R:R:A202	R:R:Y110	4	0	No	Yes	4	5	2	1
L:L:T32	R:R:Y110	3.75	0	No	Yes	0	5	0	1
L:L:Q34	R:R:Y110	5.64	4	Yes	Yes	0	5	0	1
L:L:Q34	R:R:Q130	3.84	4	Yes	No	0	6	0	1
L:L:?36	R:R:Q130	15.75	4	Yes	No	0	6	0	1
R:R:P182	R:R:Y219	5.56	0	No	Yes	8	6	2	1
R:R:E205	R:R:L183	3.98	0	Yes	Yes	4	5	1	2
R:R:L183	R:R:Y219	4.69	0	Yes	Yes	5	6	2	1
R:R:E205	R:R:R187	10.47	0	Yes	No	4	6	1	2
R:R:E188	R:R:T204	8.47	0	No	No	4	4	2	1
R:R:I194	R:R:P196	5.08	0	No	No	1	3	1	2
R:R:F198	R:R:I194	3.77	0	No	No	1	1	2	1
L:L:P5	R:R:I194	3.39	0	No	No	0	1	0	1
R:R:I195	R:R:P196	3.39	0	No	No	2	3	1	2
L:L:P8	R:R:I195	13.55	0	Yes	No	0	2	0	1
R:R:E205	R:R:W207	5.45	0	Yes	Yes	4	5	1	2
L:L:R35	R:R:E205	5.82	0	Yes	Yes	0	4	0	1
R:R:W207	R:R:Y219	3.86	0	Yes	Yes	5	6	2	1
L:L:Y1	R:R:E211	5.61	0	No	No	0	2	0	1
L:L:R35	R:R:Y219	5.14	0	Yes	Yes	0	6	0	1
R:R:H285	R:R:L227	3.86	0	Yes	No	7	6	1	2
R:R:H285	R:R:W281	9.52	0	Yes	Yes	7	8	1	2
R:R:H285	R:R:L284	3.86	0	Yes	No	7	6	1	2
L:L:?36	R:R:H285	4.35	4	Yes	Yes	0	7	0	1
R:R:F287	R:R:Q288	3.51	2	Yes	No	4	5	2	1
R:R:F287	R:R:V291	7.87	2	Yes	Yes	4	4	2	1
R:R:F287	R:R:Y303	7.22	2	Yes	Yes	4	4	2	1
R:R:F287	R:R:F307	8.57	2	Yes	No	4	4	2	1
L:L:R33	R:R:Q288	12.85	2	No	No	0	5	0	1
L:L:R35	R:R:Q288	5.84	0	Yes	No	0	5	0	1
R:R:V291	R:R:Y303	8.83	2	Yes	Yes	4	4	1	1
L:L:R33	R:R:V291	11.77	2	No	Yes	0	4	0	1
R:R:Q296	R:R:S295	4.33	0	No	No	5	1	1	2
R:R:D299	R:R:Q296	9.14	0	No	No	1	5	1	1
L:L:H26	R:R:Q296	7.42	0	No	No	0	5	0	1
R:R:L298	R:R:Y303	3.52	0	No	Yes	1	4	1	1
L:L:H26	R:R:L298	15.43	0	No	No	0	1	0	1
L:L:R25	R:R:D299	10.72	0	No	No	0	1	0	1
R:R:E302	R:R:K301	5.4	0	No	No	3	3	2	1
L:L:R25	R:R:K301	3.71	0	No	No	0	3	0	1
L:L:N29	R:R:Y303	15.12	0	No	Yes	0	4	0	1
L:L:R33	R:R:Y303	4.12	2	No	Yes	0	4	0	1
L:L:N29	R:R:K304	5.6	0	No	No	0	4	0	1
L:L:Q34	R:R:F307	5.86	4	Yes	No	0	4	0	1
R:R:H311	R:R:M315	11.82	0	No	No	5	7	1	2
L:L:?36	R:R:H311	7.61	4	Yes	No	0	5	0	1
R:R:V291	R:R:V297	3.21	2	Yes	No	4	6	1	2
R:R:I192	R:R:S190	3.1	0	No	No	2	1	1	2
R:R:H285	R:R:L224	2.57	0	Yes	No	7	5	1	2
L:L:?36	R:R:S223	2.54	4	Yes	No	0	5	0	1
L:L:Y21	R:R:L40	2.34	0	No	No	0	7	0	1
L:L:I31	R:R:T204	1.52	0	Yes	No	0	4	0	1
R:R:K304	R:R:T111	1.5	0	No	No	4	4	1	2
L:L:I31	R:R:I192	1.47	0	Yes	No	0	2	0	1
R:R:D299	R:R:L300	1.36	0	No	No	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X9B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	309
Number of Links	320
Number of Hubs	31
Number of Links mediated by Hubs	119
Number of Communities	5
Number of Nodes involved in Communities	19
Number of Links involved in Communities	21

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	63988
Length Of Smallest Path	3
Average Path Length	14.5058
Length of Longest Path	32
Minimum Path Strength	1.495
Average Path Strength	6.10309
Maximum Path Strength	15.505
Minimum Path Correlation	0.7
Average Path Correlation	0.942312
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	57.3736
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.6732
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide Y receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • transporter regulator activity • neuropeptide signaling pathway • nerve growth factor production • regulation of nerve growth factor production • regulation of multicellular organismal process • neurotrophin production • regulation of neurotrophin production • cellular developmental process • central nervous system neuron development • cell development • nervous system development • generation of neurons • central nervous system neuron differentiation • neurogenesis • central nervous system development • neuron differentiation • cell differentiation • neuron development • response to light stimulus • photoperiodism • response to radiation • response to abiotic stimulus • short-day photoperiodism • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell-substrate adhesion • cell adhesion • positive regulation of cell-substrate adhesion • epithelium development • digestive system development • intestinal epithelial cell differentiation • tube development • tissue development • digestive tract development • epithelial cell differentiation • columnar/cuboidal epithelial cell differentiation • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • positive regulation of dopamine metabolic process • regulation of primary metabolic process • amine metabolic process • positive regulation of metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • positive regulation of amine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response to antigenic stimulus • response to stress • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • acute inflammatory response • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • regulation of acute inflammatory response • inflammatory response • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • regulation of biological quality • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • behavior • feeding behavior • positive regulation of cell population proliferation • regulation of cell population proliferation • head development • forebrain development • brain development • pallium development • cerebral cortex development • telencephalon development • monocyte activation • cell activation • myeloid leukocyte activation • leukocyte activation • synaptic signaling via neuropeptide • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • regulation of behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of localization • cellular localization • regulated exocytosis • transport • modulation of chemical synaptic transmission • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • localization • regulation of secretion by cell • secretion by cell • signal release • establishment of localization in cell • neurotransmitter secretion • regulation of transport • secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • export from cell • neurotransmitter transport • regulation of vesicle-mediated transport • establishment of localization • regulation of secretion • signal release from synapse • regulation of trans-synaptic signaling • exocytosis • regulation of neurotransmitter secretion • regulation of exocytosis • adult feeding behavior • adult behavior • plasma membrane bounded cell projection organization • cell projection organization • neuron projection development • cellular component organization • cellular component organization or biogenesis • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • perikaryon • neuronal cell body • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • axon • axon terminus • presynapse • distal axon • terminal bouton • neuron projection terminus • GABA-ergic synapse • perinuclear region of cytoplasm • peptide receptor activity • neuropeptide Y receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • peptide YY receptor activity • positive regulation of cytosolic calcium ion concentration • locomotory behavior • nitric oxide mediated signal transduction • negative regulation of transport • negative regulation of secretion • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, non-REM sleep • regulation of circadian rhythm • circadian sleep/wake cycle, non-REM sleep • sleep • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • positive regulation of circadian sleep/wake cycle, non-REM sleep • circadian rhythm • circadian behavior • positive regulation of circadian rhythm • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of peptide secretion • nitrogen compound transport • regulation of peptide secretion • regulation of peptide transport • peptide transport • peptide secretion • positive regulation of secretion • positive regulation of transport • amide transport • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • catecholamine transport • positive regulation of catecholamine secretion • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • heart development • cardiac chamber morphogenesis • heart morphogenesis • circulatory system development • anatomical structure morphogenesis • cardiac ventricle morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac left ventricle morphogenesis • cardiac ventricle development • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • negative regulation of cellular process • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • negative regulation of nervous system process • regulation of system process • regulation of nervous system process • negative regulation of multicellular organismal process • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • positive regulation of smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • modulation of excitatory postsynaptic potential • cell surface receptor signaling pathway • negative regulation of excitatory postsynaptic potential • excitatory postsynaptic potential • regulation of membrane potential • behavioral defense response • fear response • behavioral fear response • multicellular organismal response to stress • negative regulation of feeding behavior • negative regulation of behavior • outflow tract morphogenesis • glutamatergic synapse
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYC
PDB Residues	L:L:?36
Environment Details	Open EMBL-EBI Page
Code	TYC
Name	L-tyrosinamide
Synonyms	L-tyrosinamide (2S)-2-amino-3-(4-hydroxyphenyl)propanamide L-Tyrosine amide Tyrosinamide Tyrosine amide
Identifier
Formula	C9 H12 N2 O2
Molecular Weight	180.204
SMILES
PubChem	151243
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49146
Sequence	>7X9B_nogp_Chain_R L I D S T K L I E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F K S M R T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G E W K M G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R H R C I V Y H L E S K I S K R I S F L I I G L A W G I S A L L A S P L A I F R E Y S L I E I I P D F E I V A C T E K W P G E E K S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G A A N D H Y H Q R R Q K T T K M L V C V V V V F A V S W L P L H A F Q L A V D I D S Q V L D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N Y R K A F L S A F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	doi.org/10.1038/s41586-020-1954-0
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	7WIH	C	Aminoacid	Metabotropic Glutamate	mGlu3; mGlu3	Homo sapiens	LY2794193	-	-	3.68	2022-03-16	doi.org/10.1038/s41422-022-00623-z
	7YON	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-	Gi1/β1/γ2	2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YON (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-		2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7DDZ	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	JNJ-31020028	-	-	2.8	2021-01-27	doi.org/10.1038/s41467-021-21030-9
	7X9B	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	7X9B (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	8K6N	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-	Gi2/β1/γ1	3.2	2024-07-31	doi.org/10.1002/mco2.565
	8K6N (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-		3.2	2024-07-31	doi.org/10.1002/mco2.565
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3

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