psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I41	R:R:K301	5.82	No	No	0	3	3
2	R:R:D42	R:R:T44	5.78	No	No	0	3	4
3	R:R:D42	R:R:K45	8.3	No	No	0	3	3
4	R:R:E302	R:R:S43	8.62	No	No	0	3	5
5	R:R:K304	R:R:T44	10.51	No	No	0	4	4
6	R:R:Q50	R:R:V51	4.3	No	No	0	4	6
7	R:R:I54	R:R:Q50	6.86	No	No	0	6	4
8	R:R:L55	R:R:V52	4.47	No	No	0	6	5
9	R:R:L53	R:R:T308	4.42	No	No	0	5	3
10	R:R:L104	R:R:Y57	7.03	No	Yes	0	7	7
11	R:R:L108	R:R:Y57	12.89	No	Yes	0	6	7
12	R:R:T308	R:R:Y57	4.99	No	Yes	0	3	7
13	R:R:H311	R:R:Y57	5.44	No	Yes	0	5	7
14	R:R:I312	R:R:Y57	13.3	No	Yes	0	5	7
15	R:R:I61	R:R:L104	7.14	No	No	0	6	7
16	R:R:F319	R:R:L63	4.87	No	No	0	7	6
17	R:R:G64	R:R:N100	5.09	No	No	0	7	6
18	R:R:L97	R:R:V65	4.47	No	No	0	7	6
19	R:R:D96	R:R:N68	4.04	No	Yes	3	9	9
20	R:R:L97	R:R:N68	10.98	No	Yes	0	7	9
21	R:R:N100	R:R:N68	4.09	No	Yes	0	6	9
22	R:R:N68	R:R:P322	8.15	Yes	No	3	9	9
23	R:R:A93	R:R:V71	3.39	No	No	0	9	9
24	R:R:H73	R:R:K77	3.93	No	No	0	4	5
25	R:R:F336	R:R:V74	5.24	No	No	0	6	7
26	R:R:A90	R:R:V75	5.09	No	No	0	6	7
27	R:R:I76	R:R:R82	6.26	No	No	0	3	6
28	R:R:M81	R:R:N86	5.61	No	Yes	0	8	8
29	R:R:A335	R:R:M81	3.22	No	No	0	6	8
30	R:R:F87	R:R:R82	8.55	No	No	0	5	6
31	R:R:N86	R:R:T83	5.85	Yes	No	0	8	7
32	R:R:F88	R:R:V84	5.24	Yes	No	0	7	6
33	R:R:I160	R:R:V84	9.22	No	No	0	5	6
34	R:R:S165	R:R:V84	6.46	No	No	0	7	6
35	R:R:D147	R:R:T85	5.78	No	No	0	8	8
36	R:R:N86	R:R:Y332	13.96	Yes	Yes	0	8	8
37	R:R:F166	R:R:F87	5.36	No	No	0	4	5
38	R:R:F88	R:R:V143	7.87	Yes	No	0	7	7
39	R:R:F88	R:R:I144	5.02	Yes	No	0	7	9
40	R:R:D147	R:R:F88	3.58	No	Yes	0	8	7
41	R:R:F88	R:R:I169	5.02	Yes	No	0	7	7
42	R:R:I89	R:R:Y325	8.46	No	Yes	0	8	9
43	R:R:I89	R:R:Y332	7.25	No	Yes	0	8	8
44	R:R:N91	R:R:T140	8.77	No	No	0	9	8
45	R:R:I169	R:R:N91	5.66	No	No	0	7	9
46	R:R:N91	R:R:W173	10.17	No	Yes	0	9	9
47	R:R:L92	R:R:T140	4.42	No	No	0	9	8
48	R:R:L141	R:R:L92	5.54	No	No	0	8	9
49	R:R:D96	R:R:T318	5.78	No	No	0	9	9
50	R:R:D96	R:R:P322	4.83	No	No	3	9	9
51	R:R:C103	R:R:V99	6.83	No	No	0	6	7
52	R:R:N100	R:R:T318	10.24	No	No	0	6	9
53	R:R:L102	R:R:T101	4.42	No	No	0	5	5
54	R:R:A129	R:R:L102	4.73	No	No	0	5	5
55	R:R:C103	R:R:Q130	4.58	No	No	0	6	6
56	R:R:C103	R:R:M315	3.24	No	No	0	6	7
57	R:R:F106	R:R:W116	7.02	No	Yes	0	5	8
58	R:R:F106	R:R:V126	9.18	No	No	0	5	5
59	L:L:Q34	R:R:T107	12.76	Yes	No	0	0	6
60	R:R:L108	R:R:L112	4.15	No	No	0	6	4
61	R:R:W116	R:R:Y110	8.68	Yes	Yes	0	8	5
62	R:R:A202	R:R:Y110	4	No	Yes	0	4	5
63	L:L:T32	R:R:Y110	3.75	No	Yes	0	0	5
64	L:L:Q34	R:R:Y110	5.64	Yes	Yes	0	0	5
65	R:R:E115	R:R:K117	21.6	No	No	0	5	3
66	R:R:E115	R:R:I200	5.47	No	No	0	5	3
67	R:R:M118	R:R:W116	10.47	No	Yes	5	7	8
68	R:R:L122	R:R:W116	4.56	No	Yes	5	6	8
69	R:R:C123	R:R:W116	16.98	No	Yes	0	9	8
70	R:R:L122	R:R:M118	4.24	No	No	5	6	7
71	R:R:G119	R:R:P120	4.06	No	No	0	8	3
72	R:R:P120	R:R:Y189	16.69	No	No	0	3	5
73	R:R:C123	R:R:C203	7.28	No	No	0	9	9
74	R:R:H124	R:R:R187	4.51	No	No	0	7	6
75	R:R:P127	R:R:V126	3.53	No	No	0	5	5
76	R:R:L183	R:R:P127	3.28	Yes	No	0	5	5
77	R:R:P127	R:R:R187	8.65	No	No	0	5	6
78	R:R:A184	R:R:Y128	4	No	No	0	5	6
79	L:L:Q34	R:R:Q130	3.84	Yes	No	4	0	6
80	L:L:?36	R:R:Q130	15.75	Yes	No	4	0	6
81	R:R:L132	R:R:W173	6.83	No	Yes	0	5	9
82	R:R:V134	R:R:W281	7.36	No	Yes	0	7	8
83	R:R:I139	R:R:Q135	4.12	No	No	0	5	6
84	R:R:L179	R:R:Q135	13.31	No	No	0	5	6
85	R:R:L227	R:R:Q135	6.65	No	No	0	6	6
86	R:R:V136	R:R:W173	20.84	No	Yes	0	7	9
87	R:R:S176	R:R:V136	3.23	No	No	0	8	7
88	R:R:P231	R:R:T138	5.25	Yes	No	1	9	8
89	R:R:F277	R:R:T138	3.89	Yes	No	1	9	8
90	R:R:L141	R:R:N321	4.12	No	No	0	8	9
91	R:R:L141	R:R:Y325	3.52	No	Yes	0	8	9
92	R:R:P231	R:R:T142	3.5	Yes	No	0	9	7
93	R:R:I234	R:R:T142	6.08	No	No	0	6	7
94	R:R:I144	R:R:R148	5.01	No	No	0	9	9
95	R:R:A145	R:R:I235	3.25	No	No	0	9	8
96	R:R:R148	R:R:Y239	8.23	No	Yes	0	9	9
97	R:R:R148	R:R:Y325	6.17	No	Yes	0	9	9
98	R:R:H149	R:R:V153	8.3	Yes	No	0	8	7
99	R:R:H149	R:R:Y154	3.27	Yes	No	0	8	7
100	R:R:H149	R:R:S238	5.58	Yes	No	0	8	7
101	R:R:H149	R:R:R241	3.39	Yes	No	0	8	4
102	R:R:E157	R:R:R150	4.65	No	No	0	4	4
103	R:R:I160	R:R:R150	6.26	No	No	0	5	4
104	R:R:I152	R:R:I242	10.3	No	No	0	8	8
105	R:R:H155	R:R:K245	7.86	No	No	0	8	5
106	R:R:I164	R:R:S161	4.64	No	No	0	5	6
107	R:R:F166	R:R:S165	5.28	No	No	0	4	7
108	R:R:P182	R:R:S181	5.34	No	No	0	8	4
109	R:R:P182	R:R:Y219	5.56	No	Yes	0	8	6
110	R:R:E205	R:R:L183	3.98	Yes	Yes	0	4	5
111	R:R:L183	R:R:Y219	4.69	Yes	Yes	0	5	6
112	R:R:F186	R:R:I185	3.77	No	No	0	5	4
113	R:R:F186	R:R:W207	16.04	No	Yes	0	5	5
114	R:R:E205	R:R:R187	10.47	Yes	No	0	4	6
115	R:R:E188	R:R:T204	8.47	No	No	0	4	4
116	R:R:E188	R:R:K206	8.1	No	No	0	4	3
117	R:R:V201	R:R:Y189	7.57	No	No	0	4	5
118	R:R:E193	R:R:E199	16.49	No	No	0	2	4
119	R:R:I194	R:R:P196	5.08	No	No	0	1	3
120	R:R:F198	R:R:I194	3.77	No	No	0	1	1
121	L:L:P5	R:R:I194	3.39	No	No	0	0	1
122	R:R:I195	R:R:P196	3.39	No	No	0	2	3
123	L:L:P8	R:R:I195	13.55	Yes	No	0	0	2
124	R:R:D197	R:R:E199	3.9	No	No	0	4	4
125	R:R:F198	R:R:I200	6.28	No	No	0	1	3
126	R:R:E205	R:R:W207	5.45	Yes	Yes	0	4	5
127	L:L:R35	R:R:E205	5.82	Yes	Yes	0	0	4
128	R:R:S213	R:R:W207	4.94	No	Yes	0	2	5
129	R:R:G216	R:R:W207	9.85	No	Yes	0	4	5
130	R:R:W207	R:R:Y219	3.86	Yes	Yes	0	5	6
131	R:R:E210	R:R:G209	3.27	No	No	0	1	4
132	L:L:Y1	R:R:E211	5.61	No	No	0	0	2
133	R:R:I214	R:R:K212	10.18	No	No	0	1	3
134	R:R:D292	R:R:T217	7.23	No	No	0	5	3
135	R:R:I293	R:R:T217	6.08	No	No	0	4	3
136	L:L:R35	R:R:Y219	5.14	Yes	Yes	0	0	6
137	R:R:D292	R:R:S220	8.83	No	No	0	5	4
138	R:R:H285	R:R:L227	3.86	Yes	No	0	7	6
139	R:R:L232	R:R:Y228	4.69	Yes	No	0	5	8
140	R:R:L282	R:R:Y228	12.89	No	No	0	5	8
141	R:R:F277	R:R:P231	4.33	Yes	Yes	1	9	9
142	R:R:G233	R:R:L232	3.42	No	Yes	0	3	5
143	R:R:F277	R:R:L232	3.65	Yes	Yes	0	9	5
144	R:R:I235	R:R:Y239	4.84	No	Yes	0	8	9
145	R:R:F237	R:R:R241	6.41	No	No	0	4	4
146	R:R:S238	R:R:Y239	3.82	No	Yes	0	7	9
147	R:R:L270	R:R:Y239	15.24	No	Yes	0	8	9
148	R:R:R241	R:R:S244	3.95	No	No	0	4	4
149	R:R:T267	R:R:W243	4.85	No	No	0	6	5
150	R:R:L246	R:R:R263	3.64	No	Yes	0	8	7
151	R:R:K247	R:R:R263	13.61	No	Yes	0	6	7
152	R:R:H249	R:R:Y259	5.44	No	No	0	6	4
153	R:R:D257	R:R:V250	4.38	Yes	No	0	4	4
154	R:R:P252	R:R:S251	5.34	No	Yes	0	4	4
155	R:R:N256	R:R:S251	8.94	No	Yes	0	4	4
156	R:R:D257	R:R:S251	8.83	Yes	Yes	0	4	4
157	R:R:N256	R:R:Y259	5.81	No	No	0	4	4
158	R:R:D257	R:R:Y259	3.45	Yes	No	0	4	4
159	R:R:H260	R:R:R263	12.41	No	Yes	0	4	7
160	R:R:Q264	R:R:R263	3.5	No	Yes	0	5	7
161	R:R:Q264	R:R:T267	4.25	No	No	0	5	6
162	R:R:K265	R:R:K268	4.31	No	No	0	8	6
163	R:R:M269	R:R:M328	5.78	No	No	0	8	7
164	R:R:F277	R:R:W281	8.02	Yes	Yes	1	9	8
165	R:R:S280	R:R:W281	8.65	No	Yes	1	8	8
166	R:R:S280	R:R:S317	4.89	No	No	1	8	9
167	R:R:H285	R:R:W281	9.52	Yes	Yes	0	7	8
168	R:R:S317	R:R:W281	6.18	No	Yes	1	9	8
169	R:R:L282	R:R:P283	3.28	No	No	0	5	9
170	R:R:F310	R:R:P283	4.33	No	No	0	6	9
171	R:R:H285	R:R:L284	3.86	Yes	No	0	7	6
172	R:R:A314	R:R:L284	4.73	No	No	0	7	6
173	L:L:?36	R:R:H285	4.35	Yes	Yes	0	0	7
174	R:R:F287	R:R:Q288	3.51	Yes	No	0	4	5
175	R:R:F287	R:R:V291	7.87	Yes	Yes	2	4	4
176	R:R:F287	R:R:Y303	7.22	Yes	Yes	2	4	4
177	R:R:F287	R:R:I306	6.28	Yes	No	0	4	5
178	R:R:F287	R:R:F307	8.57	Yes	No	0	4	4
179	R:R:F287	R:R:F310	7.5	Yes	No	0	4	6
180	L:L:R33	R:R:Q288	12.85	No	No	0	0	5
181	L:L:R35	R:R:Q288	5.84	Yes	No	0	0	5
182	R:R:I293	R:R:L289	4.28	No	No	0	4	5
183	R:R:A290	R:R:V297	5.09	No	No	0	5	6
184	R:R:V291	R:R:Y303	8.83	Yes	Yes	2	4	4
185	L:L:R33	R:R:V291	11.77	No	Yes	2	0	4
186	R:R:D294	R:R:V297	4.38	No	No	0	2	6
187	R:R:Q296	R:R:S295	4.33	No	No	0	5	1
188	R:R:D299	R:R:Q296	9.14	No	No	0	1	5
189	L:L:H26	R:R:Q296	7.42	No	No	0	0	5
190	R:R:L298	R:R:Y303	3.52	No	Yes	0	1	4
191	L:L:H26	R:R:L298	15.43	No	No	0	0	1
192	L:L:R25	R:R:D299	10.72	No	No	0	0	1
193	R:R:E302	R:R:K301	5.4	No	No	0	3	3
194	L:L:R25	R:R:K301	3.71	No	No	0	0	3
195	R:R:E302	R:R:L305	3.98	No	No	0	3	1
196	L:L:N29	R:R:Y303	15.12	No	Yes	0	0	4
197	L:L:R33	R:R:Y303	4.12	No	Yes	2	0	4
198	L:L:N29	R:R:K304	5.6	No	No	0	0	4
199	L:L:Q34	R:R:F307	5.86	Yes	No	0	0	4
200	R:R:H311	R:R:M315	11.82	No	No	0	5	7
201	L:L:?36	R:R:H311	7.61	Yes	No	0	0	5
202	R:R:M315	R:R:T318	6.02	No	No	0	7	9
203	R:R:N321	R:R:S317	4.47	No	No	0	9	9
204	R:R:L324	R:R:Y325	8.21	No	Yes	0	8	9
205	R:R:G326	R:R:Y332	4.35	No	Yes	0	7	8
206	R:R:M328	R:R:W327	8.14	No	No	0	7	6
207	R:R:R333	R:R:W327	12	No	No	0	8	6
208	R:R:N329	R:R:N331	4.09	No	No	0	8	6
209	R:R:F336	R:R:F340	6.43	No	No	0	6	5
210	R:R:L337	R:R:R341	3.64	No	No	0	4	3
211	L:L:K4	L:L:Y1	8.36	No	No	0	0	0
212	L:L:K4	L:L:S3	10.71	No	No	0	0	0
213	L:L:D6	L:L:K4	5.53	No	No	0	0	0
214	L:L:P5	L:L:Y27	5.56	No	No	0	0	0
215	L:L:D16	L:L:N7	6.73	No	No	0	0	0
216	L:L:A12	L:L:D16	4.63	No	No	0	0	0
217	L:L:E15	L:L:P13	4.72	No	No	0	0	0
218	L:L:M17	L:L:Y21	3.59	No	No	0	0	0
219	L:L:L24	L:L:Y20	3.52	No	No	0	0	0
220	L:L:I31	L:L:Y27	3.63	Yes	No	0	0	0
221	L:L:I31	L:L:T32	4.56	Yes	No	0	0	0
222	L:L:?36	L:L:Q34	7.87	Yes	Yes	4	0	0
223	L:L:?36	L:L:R35	10.27	Yes	Yes	0	0	0
224	R:R:V271	R:R:V274	3.21	No	No	0	6	8
225	R:R:V291	R:R:V297	3.21	Yes	No	0	4	6
226	R:R:A177	R:R:L132	3.15	No	No	0	4	5
227	R:R:I192	R:R:S190	3.1	No	No	0	2	1
228	R:R:I72	R:R:V94	3.07	No	No	0	7	6
229	R:R:I168	R:R:V143	3.07	No	No	0	5	7
230	R:R:I235	R:R:V274	3.07	No	No	0	8	8
231	R:R:K117	R:R:V201	3.04	No	No	0	3	4
232	R:R:F336	R:R:G326	3.01	No	No	0	6	7
233	R:R:L92	R:R:S137	3	No	No	0	9	9
234	R:R:L46	R:R:V49	2.98	No	No	0	2	4
235	R:R:L53	R:R:V49	2.98	No	No	0	5	4
236	R:R:L324	R:R:V273	2.98	No	No	0	8	8
237	R:R:N321	R:R:V276	2.96	No	No	0	9	6
238	R:R:L97	R:R:T101	2.95	No	No	0	7	5
239	R:R:I312	R:R:I60	2.94	No	No	0	5	7
240	R:R:I160	R:R:I164	2.94	No	No	0	5	5
241	R:R:I54	R:R:L108	2.85	No	No	0	6	6
242	R:R:I234	R:R:L146	2.85	No	No	0	6	6
243	R:R:I168	R:R:L167	2.85	No	No	0	5	3
244	R:R:I226	R:R:L230	2.85	No	No	0	4	6
245	R:R:I242	R:R:L246	2.85	No	No	0	8	8
246	R:R:C316	R:R:F319	2.79	No	No	0	5	7
247	L:L:P8	L:L:Y20	2.78	Yes	No	0	0	0
248	R:R:A335	R:R:F78	2.77	No	No	0	6	5
249	R:R:A339	R:R:F78	2.77	No	No	0	4	5
250	R:R:L224	R:R:L289	2.77	No	No	0	5	5
251	R:R:E48	R:R:I47	2.73	No	No	0	2	2
252	R:R:N331	R:R:N86	2.72	No	Yes	0	6	8
253	L:L:E10	L:L:M17	2.71	No	No	0	0	0
254	R:R:P208	R:R:W207	2.7	No	Yes	0	4	5
255	L:L:D6	L:L:N7	2.69	No	No	0	0	0
256	R:R:A177	R:R:Y128	2.67	No	No	0	4	6
257	R:R:A180	R:R:Y128	2.67	No	No	0	7	6
258	R:R:F78	R:R:S338	2.64	No	No	0	5	4
259	L:L:R25	L:L:S22	2.64	No	No	0	0	0
260	L:L:D16	L:L:E15	2.6	No	No	0	0	0
261	R:R:H285	R:R:L224	2.57	Yes	No	0	7	5
262	L:L:H26	L:L:L30	2.57	No	No	0	0	0
263	R:R:H258	R:R:N256	2.55	No	No	0	4	4
264	L:L:?36	R:R:S223	2.54	Yes	No	0	0	5
265	R:R:V75	R:R:Y332	2.52	No	Yes	0	7	8
266	R:R:D257	R:R:H260	2.52	Yes	No	0	4	4
267	R:R:F166	R:R:K162	2.48	No	No	0	4	1
268	R:R:I242	R:R:Y239	2.42	No	Yes	0	8	9
269	L:L:Y21	R:R:L40	2.34	No	No	0	0	7
270	L:L:L24	L:L:Y21	2.34	No	No	0	0	0
271	L:L:G9	L:L:P8	2.03	No	Yes	0	0	0
272	R:R:A254	R:R:G253	1.95	No	No	0	3	4
273	R:R:W207	R:R:Y215	1.93	Yes	No	0	5	3
274	R:R:G233	R:R:S236	1.86	No	No	0	3	5
275	R:R:G253	R:R:S251	1.86	No	Yes	0	4	4
276	R:R:P322	R:R:V71	1.77	No	No	0	9	9
277	R:R:G67	R:R:I66	1.76	No	No	0	8	4
278	R:R:G170	R:R:I169	1.76	No	No	0	4	7
279	R:R:A56	R:R:S59	1.71	No	No	0	5	5
280	R:R:G64	R:R:L63	1.71	No	No	0	7	6
281	R:R:A95	R:R:S137	1.71	No	No	0	8	9
282	R:R:G131	R:R:L183	1.71	No	Yes	0	4	5
283	R:R:A133	R:R:V99	1.7	No	No	0	7	7
284	R:R:A320	R:R:V276	1.7	No	No	0	6	6
285	R:R:I61	R:R:P105	1.69	No	No	0	6	8
286	R:R:I313	R:R:P283	1.69	No	No	0	7	9
287	R:R:C151	R:R:I152	1.64	No	No	0	8	8
288	R:R:L230	R:R:P231	1.64	No	Yes	0	6	9
289	L:L:N7	L:L:P8	1.63	No	Yes	0	0	0
290	R:R:A172	R:R:I139	1.62	No	No	0	7	5
291	R:R:A339	R:R:K77	1.61	No	No	0	4	5
292	R:R:D197	R:R:P196	1.61	No	No	0	4	3
293	R:R:C58	R:R:L55	1.59	No	No	0	4	6
294	R:R:T217	R:R:V218	1.59	No	No	0	3	4
295	R:R:A133	R:R:L98	1.58	No	No	0	7	7
296	R:R:A278	R:R:L232	1.58	No	Yes	0	5	5
297	R:R:A286	R:R:L282	1.58	No	No	0	6	5
298	R:R:I60	R:R:S59	1.55	No	No	0	7	5
299	R:R:I47	R:R:V51	1.54	No	No	0	2	6
300	R:R:I214	R:R:V218	1.54	No	No	0	1	4
301	L:L:A12	L:L:D11	1.54	No	No	0	0	0
302	L:L:I31	R:R:T204	1.52	Yes	No	0	0	4
303	R:R:M269	R:R:V273	1.52	No	No	0	8	8
304	R:R:K159	R:R:T83	1.5	No	No	0	5	7
305	R:R:K304	R:R:T111	1.5	No	No	0	4	4
306	R:R:L98	R:R:V94	1.49	No	No	0	7	6
307	R:R:L191	R:R:V201	1.49	No	No	0	3	4
308	R:R:N248	R:R:S244	1.49	No	No	0	4	4
309	L:L:I31	R:R:I192	1.47	Yes	No	0	0	2
310	R:R:I175	R:R:L179	1.43	No	No	0	4	5
311	R:R:I226	R:R:L225	1.43	No	No	0	4	5
312	L:L:I28	L:L:L24	1.43	No	No	0	0	0
313	R:R:G174	R:R:W173	1.41	No	Yes	0	4	9
314	L:L:P2	L:L:Y1	1.39	No	No	0	0	0
315	R:R:L221	R:R:L289	1.38	No	No	0	4	5
316	R:R:D299	R:R:L300	1.36	No	No	0	1	1
317	L:L:R19	L:L:S22	1.32	No	No	0	0	0
318	R:R:F310	R:R:V309	1.31	No	No	0	6	6
319	R:R:K79	R:R:R82	1.24	No	No	0	6	6
320	R:R:F340	R:R:L70	1.22	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y57	8.73	5	0	7
2	R:R:N68	6.815	4	3	9
3	R:R:N86	7.035	4	0	8
4	R:R:F88	5.346	5	0	7
5	R:R:Y110	5.5175	4	0	5
6	R:R:W116	9.542	5	5	8
7	R:R:H149	5.135	4	0	8
8	R:R:W173	9.8125	4	0	9
9	R:R:L183	3.415	4	0	5
10	R:R:E205	6.43	4	0	4
11	R:R:W207	6.39571	7	0	5
12	R:R:Y219	4.8125	4	0	6
13	R:R:P231	3.68	4	1	9
14	R:R:L232	3.335	4	0	5
15	R:R:Y239	6.91	5	0	9
16	R:R:S251	6.2425	4	0	4
17	R:R:D257	4.795	4	0	4
18	R:R:R263	8.29	4	0	7
19	R:R:F277	4.9725	4	1	9
20	R:R:W281	7.946	5	1	8
21	R:R:H285	4.832	5	0	7
22	R:R:F287	6.825	6	2	4
23	R:R:V291	7.92	4	2	4
24	R:R:Y303	7.762	5	2	4
25	R:R:Y325	6.59	4	0	9
26	R:R:Y332	7.02	4	0	8
27	L:L:P8	4.9975	4	0	0
28	L:L:I31	2.795	4	0	0
29	L:L:Q34	7.194	5	4	0
30	L:L:R35	6.7675	4	0	0
31	L:L:?36	8.065	6	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N29	R:R:K304	11.5548	5.6	No	No	0	0	4
2	L:L:N29	R:R:Y303	13.8476	15.12	No	Yes	0	0	4
3	R:R:L298	R:R:Y303	34.2026	3.52	No	Yes	0	1	4
4	L:L:H26	R:R:L298	31.9659	15.43	No	No	0	0	1
5	L:L:H26	R:R:Q296	27.4738	7.42	No	No	0	0	5
6	R:R:D299	R:R:Q296	22.9567	9.14	No	No	0	1	5
7	L:L:R25	R:R:D299	18.4146	10.72	No	No	0	0	1
8	L:L:R25	R:R:K301	11.5548	3.71	No	No	0	0	3
9	R:R:F287	R:R:Y303	34.8515	7.22	Yes	Yes	2	4	4
10	R:R:F287	R:R:Q288	21.6215	3.51	Yes	No	0	4	5
11	L:L:R35	R:R:Q288	40.1329	5.84	Yes	No	0	0	5
12	L:L:?36	L:L:R35	56.8474	10.27	Yes	Yes	0	0	0
13	L:L:?36	R:R:H311	44.3256	7.61	Yes	No	0	0	5
14	R:R:H311	R:R:Y57	21.3938	5.44	No	Yes	0	5	7
15	L:L:R33	R:R:Y303	14.9488	4.12	No	Yes	2	0	4
16	L:L:R33	R:R:Q288	18.4365	12.85	No	No	0	0	5
17	R:R:F287	R:R:F307	27.8575	8.57	Yes	No	0	4	4
18	L:L:Q34	R:R:F307	28.575	5.86	Yes	No	0	0	4
19	L:L:?36	L:L:Q34	55.4592	7.87	Yes	Yes	4	0	0
20	R:R:N100	R:R:T318	15.4542	10.24	No	No	0	6	9
21	R:R:M315	R:R:T318	30.8117	6.02	No	No	0	7	9
22	R:R:C103	R:R:Q130	11.5766	4.58	No	No	0	6	6
23	R:R:H311	R:R:M315	25.4835	11.82	No	No	0	5	7
24	R:R:D96	R:R:T318	14.0504	5.78	No	No	0	9	9
25	R:R:L97	R:R:N68	14.1908	10.98	No	Yes	0	7	9
26	R:R:N86	R:R:Y332	13.5981	13.96	Yes	Yes	0	8	8
27	R:R:I89	R:R:Y332	22.1893	7.25	No	Yes	0	8	8
28	R:R:I89	R:R:Y325	23.2375	8.46	No	Yes	0	8	9
29	R:R:L141	R:R:Y325	74.5602	3.52	No	Yes	0	8	9
30	R:R:L141	R:R:N321	87.1319	4.12	No	No	0	8	9
31	R:R:N321	R:R:S317	88.7135	4.47	No	No	0	9	9
32	R:R:S317	R:R:W281	88.8976	6.18	No	Yes	1	9	8
33	R:R:H285	R:R:W281	93.7765	9.52	Yes	Yes	0	7	8
34	L:L:?36	R:R:H285	100	4.35	Yes	Yes	0	0	7
35	R:R:R148	R:R:Y325	54.4734	6.17	No	Yes	0	9	9
36	R:R:I144	R:R:R148	22.7789	5.01	No	No	0	9	9
37	R:R:F88	R:R:I144	21.8087	5.02	Yes	No	0	7	9
38	R:R:F88	R:R:V84	14.718	5.24	Yes	No	0	7	6
39	R:R:N91	R:R:T140	11.5548	8.77	No	No	0	9	8
40	R:R:L92	R:R:T140	12.525	4.42	No	No	0	9	8
41	R:R:L141	R:R:L92	15.4168	5.54	No	No	0	8	9
42	R:R:N91	R:R:W173	10.3007	10.17	No	Yes	0	9	9
43	L:L:Q34	R:R:Y110	47.9005	5.64	Yes	Yes	0	0	5
44	L:L:R35	R:R:E205	14.9208	5.82	Yes	Yes	0	0	4
45	L:L:R35	R:R:Y219	13.3579	5.14	Yes	Yes	0	0	6
46	L:L:T32	R:R:Y110	42.092	3.75	No	Yes	0	0	5
47	L:L:P5	R:R:I194	34.6893	3.39	No	No	0	0	1
48	L:L:P5	L:L:Y27	35.5316	5.56	No	No	0	0	0
49	L:L:I31	L:L:Y27	36.3832	3.63	Yes	No	0	0	0
50	L:L:I31	L:L:T32	41.2934	4.56	Yes	No	0	0	0
51	R:R:F277	R:R:W281	16.6396	8.02	Yes	Yes	1	9	8
52	R:R:R148	R:R:Y239	38.1489	8.23	No	Yes	0	9	9
53	R:R:I242	R:R:Y239	24.2763	2.42	No	Yes	0	8	9
54	R:R:I194	R:R:P196	25.861	5.08	No	No	0	1	3
55	R:R:I195	R:R:P196	22.155	3.39	No	No	0	2	3
56	L:L:P8	R:R:I195	21.2129	13.55	Yes	No	0	0	2
57	L:L:N7	L:L:P8	12.4563	1.63	No	Yes	0	0	0
58	R:R:L224	R:R:L289	10.3569	2.77	No	No	0	5	5
59	R:R:H285	R:R:L224	11.4768	2.57	Yes	No	0	7	5
60	R:R:I242	R:R:L246	21.1349	2.85	No	No	0	8	8
61	R:R:L246	R:R:R263	20.0618	3.64	No	Yes	0	8	7
62	R:R:D257	R:R:H260	13.5918	2.52	Yes	No	0	4	4
63	R:R:H260	R:R:R263	14.6868	12.41	No	Yes	0	4	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I41	R:R:K301	5.82	0	No	No	3	3	2	1
R:R:K304	R:R:T44	10.51	0	No	No	4	4	1	2
R:R:H311	R:R:Y57	5.44	0	No	Yes	5	7	1	2
R:R:C103	R:R:Q130	4.58	0	No	No	6	6	2	1
R:R:C103	R:R:M315	3.24	0	No	No	6	7	2	2
L:L:Q34	R:R:T107	12.76	4	Yes	No	0	6	0	1
R:R:W116	R:R:Y110	8.68	5	Yes	Yes	8	5	2	1
R:R:A202	R:R:Y110	4	0	No	Yes	4	5	2	1
L:L:T32	R:R:Y110	3.75	0	No	Yes	0	5	0	1
L:L:Q34	R:R:Y110	5.64	4	Yes	Yes	0	5	0	1
L:L:Q34	R:R:Q130	3.84	4	Yes	No	0	6	0	1
L:L:?36	R:R:Q130	15.75	4	Yes	No	0	6	0	1
R:R:P182	R:R:Y219	5.56	0	No	Yes	8	6	2	1
R:R:E205	R:R:L183	3.98	0	Yes	Yes	4	5	1	2
R:R:L183	R:R:Y219	4.69	0	Yes	Yes	5	6	2	1
R:R:E205	R:R:R187	10.47	0	Yes	No	4	6	1	2
R:R:E188	R:R:T204	8.47	0	No	No	4	4	2	1
R:R:I194	R:R:P196	5.08	0	No	No	1	3	1	2
R:R:F198	R:R:I194	3.77	0	No	No	1	1	2	1
L:L:P5	R:R:I194	3.39	0	No	No	0	1	0	1
R:R:I195	R:R:P196	3.39	0	No	No	2	3	1	2
L:L:P8	R:R:I195	13.55	0	Yes	No	0	2	0	1
R:R:E205	R:R:W207	5.45	0	Yes	Yes	4	5	1	2
L:L:R35	R:R:E205	5.82	0	Yes	Yes	0	4	0	1
R:R:W207	R:R:Y219	3.86	0	Yes	Yes	5	6	2	1
L:L:Y1	R:R:E211	5.61	0	No	No	0	2	0	1
L:L:R35	R:R:Y219	5.14	0	Yes	Yes	0	6	0	1
R:R:H285	R:R:L227	3.86	0	Yes	No	7	6	1	2
R:R:H285	R:R:W281	9.52	0	Yes	Yes	7	8	1	2
R:R:H285	R:R:L284	3.86	0	Yes	No	7	6	1	2
L:L:?36	R:R:H285	4.35	4	Yes	Yes	0	7	0	1
R:R:F287	R:R:Q288	3.51	2	Yes	No	4	5	2	1
R:R:F287	R:R:V291	7.87	2	Yes	Yes	4	4	2	1
R:R:F287	R:R:Y303	7.22	2	Yes	Yes	4	4	2	1
R:R:F287	R:R:F307	8.57	2	Yes	No	4	4	2	1
L:L:R33	R:R:Q288	12.85	2	No	No	0	5	0	1
L:L:R35	R:R:Q288	5.84	0	Yes	No	0	5	0	1
R:R:V291	R:R:Y303	8.83	2	Yes	Yes	4	4	1	1
L:L:R33	R:R:V291	11.77	2	No	Yes	0	4	0	1
R:R:Q296	R:R:S295	4.33	0	No	No	5	1	1	2
R:R:D299	R:R:Q296	9.14	0	No	No	1	5	1	1
L:L:H26	R:R:Q296	7.42	0	No	No	0	5	0	1
R:R:L298	R:R:Y303	3.52	0	No	Yes	1	4	1	1
L:L:H26	R:R:L298	15.43	0	No	No	0	1	0	1
L:L:R25	R:R:D299	10.72	0	No	No	0	1	0	1
R:R:E302	R:R:K301	5.4	0	No	No	3	3	2	1
L:L:R25	R:R:K301	3.71	0	No	No	0	3	0	1
L:L:N29	R:R:Y303	15.12	0	No	Yes	0	4	0	1
L:L:R33	R:R:Y303	4.12	2	No	Yes	0	4	0	1
L:L:N29	R:R:K304	5.6	0	No	No	0	4	0	1
L:L:Q34	R:R:F307	5.86	4	Yes	No	0	4	0	1
R:R:H311	R:R:M315	11.82	0	No	No	5	7	1	2
L:L:?36	R:R:H311	7.61	4	Yes	No	0	5	0	1
R:R:V291	R:R:V297	3.21	2	Yes	No	4	6	1	2
R:R:I192	R:R:S190	3.1	0	No	No	2	1	1	2
R:R:H285	R:R:L224	2.57	0	Yes	No	7	5	1	2
L:L:?36	R:R:S223	2.54	4	Yes	No	0	5	0	1
L:L:Y21	R:R:L40	2.34	0	No	No	0	7	0	1
L:L:I31	R:R:T204	1.52	0	Yes	No	0	4	0	1
R:R:K304	R:R:T111	1.5	0	No	No	4	4	1	2
L:L:I31	R:R:I192	1.47	0	Yes	No	0	2	0	1
R:R:D299	R:R:L300	1.36	0	No	No	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X9B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	309
Number of Links	320
Number of Hubs	31
Number of Links mediated by Hubs	119
Number of Communities	5
Number of Nodes involved in Communities	19
Number of Links involved in Communities	21

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	63988
Length Of Smallest Path	3
Average Path Length	14.5058
Length of Longest Path	32
Minimum Path Strength	1.495
Average Path Strength	6.10309
Maximum Path Strength	15.505
Minimum Path Correlation	0.7
Average Path Correlation	0.942325
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	57.3247
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.6732
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • signaling receptor activity • peptide receptor activity • neuropeptide Y receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • peptide YY receptor activity • calcium channel activity • monoatomic cation transmembrane transporter activity • channel regulator activity • monoatomic ion channel activity • ion channel regulator activity • calcium channel regulator activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • inorganic cation transmembrane transporter activity • molecular function regulator activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transporter regulator activity • transmembrane transporter activity • heart development • cardiac chamber morphogenesis • heart morphogenesis • circulatory system development • anatomical structure morphogenesis • cardiac ventricle morphogenesis • cardiac chamber development • animal organ morphogenesis • cardiac left ventricle morphogenesis • cardiac ventricle development • behavior • locomotory behavior • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • outflow tract morphogenesis • signaling receptor binding • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide Y receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • neuropeptide signaling pathway • cellular developmental process • central nervous system neuron development • cell development • nervous system development • generation of neurons • central nervous system neuron differentiation • neurogenesis • central nervous system development • neuron differentiation • cell differentiation • neuron development • head development • forebrain development • brain development • pallium development • cerebral cortex development • telencephalon development • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • synaptic signaling via neuropeptide • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • epithelium development • digestive system development • intestinal epithelial cell differentiation • tube development • tissue development • digestive tract development • epithelial cell differentiation • columnar/cuboidal epithelial cell differentiation • adult feeding behavior • adult behavior • feeding behavior • plasma membrane bounded cell projection organization • cell projection organization • neuron projection development • cellular component organization • cellular component organization or biogenesis • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • positive regulation of biological process • positive regulation of response to stimulus • regulation of response to food • regulation of response to stimulus • response to food • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • GABA-ergic synapse
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYC
PDB Residues	L:L:?36
Environment Details	Open EMBL-EBI Page
Code	TYC
Name	L-tyrosinamide
Synonyms	(2S)-2-amino-3-(4-hydroxyphenyl)propanamide Tyrosine amide L-tyrosinamide L-Tyrosine amide Tyrosinamide
Identifier
Formula	C9 H12 N2 O2
Molecular Weight	180.204
SMILES
PubChem	151243
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49146
Sequence	>7X9B_nogp_Chain_R L I D S T K L I E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F K S M R T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G E W K M G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R H R C I V Y H L E S K I S K R I S F L I I G L A W G I S A L L A S P L A I F R E Y S L I E I I P D F E I V A C T E K W P G E E K S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G A A N D H Y H Q R R Q K T T K M L V C V V V V F A V S W L P L H A F Q L A V D I D S Q V L D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N Y R K A F L S A F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8K6N	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-	Gi2/β1/γ1	3.2	2024-07-31	To be published
	8K6N (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-		3.2	2024-07-31	To be published
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	10.1038/s41467-023-38985-6
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	10.2139/ssrn.4034884
	7YOO	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.11	2023-03-22	10.1016/j.str.2022.11.010
	7YOO (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.11	2023-03-22	10.1016/j.str.2022.11.010
	7YON	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-	Gi1/β1/γ2	2.95	2023-03-22	10.1016/j.str.2022.11.010
	7YON (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-		2.95	2023-03-22	10.1016/j.str.2022.11.010
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	10.1038/s41589-022-01130-3
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	10.1038/s41589-022-01130-3
	7X9B	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.4	2022-05-18	10.1126/sciadv.abm1232
	7X9B (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.4	2022-05-18	10.1126/sciadv.abm1232
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	10.1126/science.abm9609
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	10.1126/science.abm9609
	7WIH	C	Aminoacid	Metabotropic Glutamate	mGlu3; mGlu3	Homo sapiens	LY2794193	-	-	3.68	2022-03-16	10.1038/s41422-022-00623-z
	7DDZ	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	JNJ-31020028	-	-	2.8	2021-01-27	10.1038/s41467-021-21030-9
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	10.1038/s41586-020-1954-0
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	10.1126/science.aaw5188
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	10.1038/nature12735

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Download 7X9B_nogp.zip

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