psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y1	L:L:Y27	1.99	No	Yes	5	0	0
2	L:L:Y1	R:R:E188	10.1	No	Yes	0	0	4
3	L:L:Y1	R:R:I192	3.63	No	No	5	0	2
4	L:L:L30	L:L:P2	3.28	No	No	0	0	0
5	L:L:P2	R:R:E211	3.14	No	No	0	0	2
6	L:L:K4	L:L:S3	3.06	No	No	0	0	0
7	L:L:K4	L:L:Y27	2.39	No	Yes	0	0	0
8	L:L:K4	R:R:E193	6.75	No	No	0	0	2
9	L:L:P5	L:L:Y20	2.78	Yes	Yes	0	0	0
10	L:L:A23	L:L:P5	3.74	No	Yes	0	0	0
11	L:L:L24	L:L:P5	3.28	No	Yes	0	0	0
12	L:L:P5	L:L:Y27	4.17	Yes	Yes	0	0	0
13	L:L:D6	L:L:Y20	4.6	No	Yes	0	0	0
14	L:L:N7	L:L:P8	8.15	No	No	0	0	0
15	L:L:P8	L:L:Y20	13.91	No	Yes	0	0	0
16	L:L:A18	L:L:D16	4.63	No	No	0	0	0
17	L:L:D16	L:L:R19	3.57	No	No	0	0	0
18	L:L:M17	L:L:Y21	4.79	No	No	0	0	0
19	L:L:Y20	L:L:Y21	5.96	Yes	No	0	0	0
20	L:L:L24	R:R:L40	6.92	No	No	0	0	7
21	L:L:L24	R:R:I194	2.85	No	Yes	0	0	1
22	L:L:R25	R:R:K301	3.71	No	No	0	0	3
23	L:L:H26	L:L:L30	2.57	No	No	1	0	0
24	L:L:H26	R:R:L298	9	No	Yes	1	0	1
25	L:L:I31	L:L:Y27	2.42	No	Yes	0	0	0
26	L:L:Y27	R:R:I192	2.42	Yes	No	5	0	2
27	L:L:Y27	R:R:I194	2.42	Yes	Yes	0	0	1
28	L:L:I28	R:R:I194	2.94	No	Yes	0	0	1
29	L:L:N29	R:R:L298	2.75	Yes	Yes	1	0	1
30	L:L:N29	R:R:Y303	8.14	Yes	Yes	1	0	4
31	L:L:N29	R:R:K304	4.2	Yes	No	0	0	4
32	L:L:L30	R:R:L298	4.15	No	Yes	1	0	1
33	L:L:I31	L:L:T32	3.04	No	No	0	0	0
34	L:L:I31	R:R:T204	3.04	No	No	0	0	4
35	L:L:T32	R:R:Y110	9.99	No	Yes	0	0	5
36	L:L:R33	L:L:R35	5.33	Yes	Yes	1	0	0
37	L:L:R33	R:R:Q288	4.67	Yes	No	1	0	5
38	L:L:R33	R:R:V291	5.23	Yes	No	1	0	4
39	L:L:R33	R:R:D292	5.96	Yes	No	0	0	5
40	L:L:R33	R:R:Y303	4.12	Yes	Yes	1	0	4
41	L:L:?36	L:L:Q34	2.25	Yes	Yes	1	0	0
42	L:L:Q34	R:R:T107	7.09	Yes	Yes	1	0	6
43	L:L:Q34	R:R:Y110	11.27	Yes	Yes	0	0	5
44	L:L:Q34	R:R:T111	4.25	Yes	No	0	0	4
45	L:L:Q34	R:R:F307	4.68	Yes	Yes	1	0	4
46	L:L:?36	L:L:R35	8.21	Yes	Yes	1	0	0
47	L:L:R35	R:R:E205	11.63	Yes	No	0	0	4
48	L:L:R35	R:R:Y219	9.26	Yes	No	0	0	6
49	L:L:R35	R:R:S220	5.27	Yes	No	0	0	4
50	L:L:R35	R:R:Q288	4.67	Yes	No	1	0	5
51	L:L:?36	R:R:C103	2.68	Yes	No	1	0	6
52	L:L:?36	R:R:T107	4.98	Yes	Yes	1	0	6
53	L:L:?36	R:R:Q130	5.62	Yes	Yes	1	0	6
54	L:L:?36	R:R:G131	2.89	Yes	No	1	0	4
55	L:L:?36	R:R:V134	3.78	Yes	No	0	0	7
56	L:L:?36	R:R:L183	2.34	Yes	No	1	0	5
57	L:L:?36	R:R:F307	3.09	Yes	Yes	1	0	4
58	L:L:?36	R:R:H311	7.61	Yes	Yes	1	0	5
59	R:R:E302	R:R:S43	10.06	No	No	0	3	5
60	R:R:L46	R:R:V49	4.47	No	No	0	2	4
61	R:R:L112	R:R:Q50	3.99	Yes	No	0	4	4
62	R:R:L108	R:R:L53	2.77	No	No	0	6	5
63	R:R:L53	R:R:T308	5.9	No	No	0	5	3
64	R:R:I54	R:R:L112	2.85	No	Yes	0	6	4
65	R:R:L104	R:R:Y57	3.52	Yes	Yes	1	7	7
66	R:R:L108	R:R:Y57	11.72	No	Yes	0	6	7
67	R:R:T308	R:R:Y57	4.99	No	Yes	0	3	7
68	R:R:H311	R:R:Y57	7.62	Yes	Yes	1	5	7
69	R:R:I312	R:R:Y57	7.25	No	Yes	0	5	7
70	R:R:I60	R:R:L104	2.85	No	Yes	0	7	7
71	R:R:I61	R:R:L104	5.71	No	Yes	1	6	7
72	R:R:I61	R:R:P105	3.39	No	No	1	6	8
73	R:R:I66	R:R:L62	2.85	No	No	0	4	5
74	R:R:G64	R:R:L63	1.71	No	No	0	7	6
75	R:R:G64	R:R:N100	3.39	No	No	0	7	6
76	R:R:L97	R:R:V65	2.98	No	No	0	7	6
77	R:R:G67	R:R:I66	3.53	No	No	0	8	4
78	R:R:G67	R:R:P322	2.03	No	No	0	8	9
79	R:R:D96	R:R:N68	4.04	Yes	No	0	9	9
80	R:R:L97	R:R:N68	5.49	No	No	0	7	9
81	R:R:N68	R:R:P322	6.52	No	No	0	9	9
82	R:R:F336	R:R:L70	2.44	Yes	No	0	6	7
83	R:R:F340	R:R:L70	3.65	No	No	0	5	7
84	R:R:A93	R:R:V71	3.39	No	No	0	9	9
85	R:R:V71	R:R:Y332	3.79	No	Yes	0	9	8
86	R:R:I72	R:R:I76	2.94	No	No	0	7	3
87	R:R:I72	R:R:V94	3.07	No	No	0	7	6
88	R:R:H73	R:R:K77	6.55	No	No	0	4	5
89	R:R:V74	R:R:Y332	2.52	No	Yes	3	7	8
90	R:R:A335	R:R:V74	3.39	No	No	0	6	7
91	R:R:F336	R:R:V74	6.55	Yes	No	3	6	7
92	R:R:V75	R:R:Y332	3.79	No	Yes	0	7	8
93	R:R:F78	R:R:K77	6.2	No	No	0	5	5
94	R:R:K79	R:R:R82	4.95	No	No	0	6	6
95	R:R:M81	R:R:N86	5.61	No	Yes	3	8	8
96	R:R:M81	R:R:Y332	2.39	No	Yes	3	8	8
97	R:R:A335	R:R:M81	3.22	No	No	0	6	8
98	R:R:F87	R:R:R82	4.28	Yes	No	0	5	6
99	R:R:N86	R:R:T83	4.39	Yes	No	0	8	7
100	R:R:F88	R:R:V84	2.62	Yes	No	2	7	6
101	R:R:I160	R:R:V84	3.07	No	No	0	5	6
102	R:R:S165	R:R:V84	9.7	No	No	2	7	6
103	R:R:N86	R:R:T85	2.92	Yes	No	0	8	8
104	R:R:D147	R:R:T85	4.34	No	No	0	8	8
105	R:R:N86	R:R:Y332	4.65	Yes	Yes	3	8	8
106	R:R:F87	R:R:K162	3.72	Yes	No	0	5	1
107	R:R:F88	R:R:V143	7.87	Yes	No	0	7	7
108	R:R:F88	R:R:I144	2.51	Yes	No	2	7	9
109	R:R:D147	R:R:F88	3.58	No	Yes	0	8	7
110	R:R:F88	R:R:S165	2.64	Yes	No	2	7	7
111	R:R:F88	R:R:I169	5.02	Yes	Yes	2	7	7
112	R:R:I89	R:R:Y325	3.63	No	Yes	0	8	9
113	R:R:I89	R:R:Y332	9.67	No	Yes	0	8	8
114	R:R:N91	R:R:T140	2.92	No	No	0	9	8
115	R:R:I169	R:R:N91	8.5	Yes	No	2	7	9
116	R:R:N91	R:R:W173	6.78	No	Yes	2	9	9
117	R:R:D96	R:R:L92	5.43	Yes	Yes	2	9	9
118	R:R:L92	R:R:S137	3	Yes	No	2	9	9
119	R:R:L92	R:R:T140	5.9	Yes	No	0	9	8
120	R:R:L92	R:R:N321	6.87	Yes	No	2	9	9
121	R:R:L92	R:R:Y325	2.34	Yes	Yes	2	9	9
122	R:R:V94	R:R:W173	2.45	No	Yes	0	6	9
123	R:R:A95	R:R:V136	3.39	No	No	0	8	7
124	R:R:A95	R:R:S137	1.71	No	No	0	8	9
125	R:R:D96	R:R:S137	4.42	Yes	No	2	9	9
126	R:R:D96	R:R:N321	6.73	Yes	No	2	9	9
127	R:R:L98	R:R:W173	2.28	No	Yes	0	7	9
128	R:R:C103	R:R:V99	5.12	No	No	0	6	7
129	R:R:T318	R:R:V99	3.17	No	No	0	9	7
130	R:R:L104	R:R:N100	4.12	Yes	No	0	7	6
131	R:R:N100	R:R:T318	13.16	No	No	0	6	9
132	R:R:F106	R:R:L102	2.44	No	No	0	5	5
133	R:R:A129	R:R:L102	3.15	No	No	0	5	5
134	R:R:C103	R:R:Q130	9.16	No	Yes	1	6	6
135	R:R:L104	R:R:P105	3.28	Yes	No	1	7	8
136	R:R:H311	R:R:L104	2.57	Yes	Yes	1	5	7
137	R:R:L104	R:R:M315	7.07	Yes	No	1	7	7
138	R:R:F106	R:R:M118	6.22	No	Yes	0	5	7
139	R:R:F106	R:R:V126	9.18	No	Yes	0	5	5
140	R:R:Q130	R:R:T107	4.25	Yes	Yes	1	6	6
141	R:R:H311	R:R:T107	10.95	Yes	Yes	1	5	6
142	R:R:L108	R:R:L112	4.15	No	Yes	0	6	4
143	R:R:M113	R:R:T109	3.01	No	No	0	4	4
144	R:R:M118	R:R:T109	3.01	Yes	No	0	7	4
145	R:R:W116	R:R:Y110	9.65	Yes	Yes	0	8	5
146	R:R:A202	R:R:Y110	4	No	Yes	0	4	5
147	R:R:G114	R:R:M113	1.75	No	No	0	5	4
148	R:R:K117	R:R:M113	4.32	No	No	0	3	4
149	R:R:E115	R:R:K117	14.85	No	No	0	5	3
150	R:R:E115	R:R:V201	2.85	No	No	0	5	4
151	R:R:M118	R:R:W116	15.12	Yes	Yes	0	7	8
152	R:R:C123	R:R:W116	5.22	No	Yes	6	9	8
153	R:R:V126	R:R:W116	6.13	Yes	Yes	0	5	8
154	R:R:C203	R:R:W116	2.61	No	Yes	6	9	8
155	R:R:G119	R:R:M118	1.75	No	Yes	0	8	7
156	R:R:L122	R:R:M118	4.24	No	Yes	0	6	7
157	R:R:G119	R:R:P120	4.06	No	No	0	8	3
158	R:R:P120	R:R:Y189	11.13	No	No	0	3	5
159	R:R:L122	R:R:V126	2.98	No	Yes	0	6	5
160	R:R:C123	R:R:R187	2.79	No	Yes	0	9	6
161	R:R:C123	R:R:C203	7.28	No	No	6	9	9
162	R:R:P127	R:R:V126	3.53	No	Yes	0	5	5
163	R:R:Q130	R:R:V126	4.3	Yes	Yes	0	6	5
164	R:R:P127	R:R:R187	11.53	No	Yes	0	5	6
165	R:R:A180	R:R:Y128	2.67	No	No	0	7	6
166	R:R:G131	R:R:L183	1.71	No	No	1	4	5
167	R:R:L132	R:R:S176	3	No	No	0	5	8
168	R:R:V134	R:R:W281	2.45	No	Yes	0	7	8
169	R:R:L227	R:R:Q135	5.32	No	No	0	6	6
170	R:R:V136	R:R:W173	12.26	No	Yes	0	7	9
171	R:R:S176	R:R:V136	3.23	No	No	0	8	7
172	R:R:P231	R:R:T138	3.5	No	No	0	9	8
173	R:R:F277	R:R:T138	2.59	No	No	0	9	8
174	R:R:L141	R:R:Y325	4.69	No	Yes	0	8	9
175	R:R:P231	R:R:T142	3.5	No	No	0	9	7
176	R:R:I234	R:R:T142	4.56	No	No	0	6	7
177	R:R:I168	R:R:V143	3.07	No	No	0	5	7
178	R:R:I144	R:R:R148	5.01	No	No	2	9	9
179	R:R:I144	R:R:Y325	4.84	No	Yes	2	9	9
180	R:R:A145	R:R:I235	3.25	No	No	2	9	8
181	R:R:A145	R:R:S238	1.71	No	No	2	9	7
182	R:R:A145	R:R:Y239	4	No	Yes	2	9	9
183	R:R:I234	R:R:L146	4.28	No	No	0	6	6
184	R:R:R148	R:R:Y239	4.12	No	Yes	2	9	9
185	R:R:R148	R:R:Y325	2.06	No	Yes	2	9	9
186	R:R:V153	R:R:Y149	7.57	No	Yes	2	7	8
187	R:R:Y149	R:R:Y154	9.93	Yes	No	2	8	7
188	R:R:F237	R:R:Y149	2.06	No	Yes	2	4	8
189	R:R:S238	R:R:Y149	3.82	No	Yes	2	7	8
190	R:R:R241	R:R:Y149	7.2	No	Yes	2	4	8
191	R:R:I160	R:R:R150	5.01	No	No	0	5	4
192	R:R:C151	R:R:K159	3.23	No	No	0	8	5
193	R:R:I152	R:R:I242	2.94	No	No	0	8	8
194	R:R:V153	R:R:Y154	6.31	No	No	2	7	7
195	R:R:H155	R:R:L156	6.43	No	No	0	8	5
196	R:R:H155	R:R:K245	5.24	No	No	0	8	5
197	R:R:R163	R:R:S161	2.64	No	No	0	5	6
198	R:R:L167	R:R:L171	6.92	No	No	0	3	3
199	R:R:G170	R:R:I169	1.76	No	Yes	0	4	7
200	R:R:I169	R:R:W173	2.35	Yes	Yes	2	7	9
201	R:R:I175	R:R:L179	2.85	No	No	0	4	5
202	R:R:P182	R:R:S181	5.34	No	No	0	8	4
203	R:R:I185	R:R:S181	3.1	No	No	0	4	4
204	R:R:F186	R:R:P182	2.89	Yes	No	0	5	8
205	R:R:L183	R:R:Y219	7.03	No	No	0	5	6
206	R:R:F186	R:R:I185	6.28	Yes	No	0	5	4
207	R:R:F186	R:R:W207	8.02	Yes	Yes	7	5	5
208	R:R:F186	R:R:P208	10.11	Yes	No	7	5	4
209	R:R:F186	R:R:Y215	2.06	Yes	No	0	5	3
210	R:R:E205	R:R:R187	5.82	No	Yes	0	4	6
211	R:R:E188	R:R:S190	4.31	Yes	No	0	4	1
212	R:R:E188	R:R:T204	7.06	Yes	No	0	4	4
213	R:R:E188	R:R:K206	9.45	Yes	No	0	4	3
214	R:R:V201	R:R:Y189	5.05	No	No	0	4	5
215	R:R:C203	R:R:Y189	4.03	No	No	0	9	5
216	R:R:I192	R:R:S190	4.64	No	No	0	2	1
217	R:R:E199	R:R:L191	3.98	No	No	0	4	3
218	R:R:F198	R:R:I194	6.28	No	Yes	0	1	1
219	R:R:I195	R:R:P196	5.08	No	No	0	2	3
220	R:R:F198	R:R:I195	5.02	No	No	0	1	2
221	R:R:F198	R:R:I200	6.28	No	No	0	1	3
222	R:R:E205	R:R:W207	3.27	No	Yes	0	4	5
223	R:R:P208	R:R:W207	2.7	No	Yes	7	4	5
224	R:R:G216	R:R:W207	8.44	No	Yes	0	4	5
225	R:R:W207	R:R:Y219	1.93	Yes	No	0	5	6
226	R:R:G209	R:R:S213	1.86	No	No	0	4	2
227	R:R:I214	R:R:T217	3.04	No	No	0	1	3
228	R:R:V218	R:R:Y215	2.52	No	No	0	4	3
229	R:R:D292	R:R:T217	2.89	No	No	0	5	3
230	R:R:D292	R:R:S220	4.42	No	No	0	5	4
231	R:R:L221	R:R:L289	2.77	No	No	0	4	5
232	R:R:L227	R:R:S223	4.5	No	No	0	6	5
233	R:R:H285	R:R:S223	2.79	Yes	No	0	7	5
234	R:R:L225	R:R:V229	2.98	No	No	0	5	4
235	R:R:I226	R:R:L227	2.85	No	No	0	4	6
236	R:R:L232	R:R:Y228	3.52	Yes	No	0	5	8
237	R:R:L282	R:R:Y228	12.89	No	No	0	5	8
238	R:R:H285	R:R:Y228	2.18	Yes	No	0	7	8
239	R:R:L230	R:R:P231	4.93	No	No	0	6	9
240	R:R:I234	R:R:L230	2.85	No	No	0	6	6
241	R:R:L232	R:R:S236	3	Yes	No	0	5	5
242	R:R:F277	R:R:L232	2.44	No	Yes	0	9	5
243	R:R:I235	R:R:Y239	2.42	No	Yes	2	8	9
244	R:R:F237	R:R:R241	3.21	No	No	2	4	4
245	R:R:S238	R:R:Y239	5.09	No	Yes	2	7	9
246	R:R:I242	R:R:Y239	2.42	No	Yes	0	8	9
247	R:R:L270	R:R:Y239	5.86	No	Yes	0	8	9
248	R:R:V273	R:R:Y239	3.79	No	Yes	2	8	9
249	R:R:V274	R:R:Y239	2.52	No	Yes	0	8	9
250	R:R:Y239	R:R:Y325	1.99	Yes	Yes	2	9	9
251	R:R:I242	R:R:L246	2.85	No	Yes	0	8	8
252	R:R:S244	R:R:W243	2.47	No	No	0	4	5
253	R:R:K247	R:R:W243	8.12	No	No	0	6	5
254	R:R:T267	R:R:W243	4.85	No	No	0	6	5
255	R:R:L246	R:R:Y259	3.52	Yes	Yes	4	8	4
256	R:R:L246	R:R:R263	2.43	Yes	Yes	4	8	7
257	R:R:K247	R:R:R263	12.38	No	Yes	0	6	7
258	R:R:H249	R:R:Y259	5.44	No	Yes	0	6	4
259	R:R:N256	R:R:V250	4.43	No	No	0	4	4
260	R:R:P252	R:R:S251	3.56	No	Yes	0	4	4
261	R:R:A255	R:R:S251	1.71	No	Yes	0	4	4
262	R:R:S251	R:R:Y259	3.82	Yes	Yes	0	4	4
263	R:R:D257	R:R:Q261	5.22	No	No	0	4	4
264	R:R:H258	R:R:R262	14.67	No	No	0	4	5
265	R:R:H260	R:R:Y259	10.89	No	Yes	4	4	4
266	R:R:R263	R:R:Y259	5.14	Yes	Yes	4	7	4
267	R:R:H260	R:R:R263	6.77	No	Yes	4	4	7
268	R:R:Q264	R:R:R263	4.67	No	Yes	0	5	7
269	R:R:M269	R:R:M328	5.78	No	No	0	8	7
270	R:R:C272	R:R:L324	3.17	No	Yes	0	6	8
271	R:R:L324	R:R:V273	7.45	Yes	No	0	8	8
272	R:R:V273	R:R:Y325	7.57	No	Yes	2	8	9
273	R:R:C280	R:R:V276	1.71	No	No	0	8	6
274	R:R:L324	R:R:V276	2.98	Yes	No	0	8	6
275	R:R:F277	R:R:W281	6.01	No	Yes	0	9	8
276	R:R:C280	R:R:C316	1.82	No	No	0	8	5
277	R:R:C280	R:R:S317	3.44	No	No	0	8	9
278	R:R:H285	R:R:W281	3.17	Yes	Yes	0	7	8
279	R:R:A314	R:R:W281	2.59	No	Yes	0	7	8
280	R:R:M315	R:R:W281	2.33	No	Yes	0	7	8
281	R:R:S317	R:R:W281	2.47	No	Yes	0	9	8
282	R:R:L282	R:R:P283	3.28	No	No	0	5	9
283	R:R:F310	R:R:P283	5.78	No	No	0	6	9
284	R:R:F307	R:R:L284	2.44	Yes	No	0	4	6
285	R:R:A314	R:R:L284	3.15	No	No	0	7	6
286	R:R:F287	R:R:V291	2.62	Yes	No	1	4	4
287	R:R:F287	R:R:V297	2.62	Yes	No	1	4	6
288	R:R:F287	R:R:Y303	6.19	Yes	Yes	1	4	4
289	R:R:F287	R:R:I306	3.77	Yes	No	1	4	5
290	R:R:F287	R:R:F310	8.57	Yes	No	1	4	6
291	R:R:F307	R:R:Q288	2.34	Yes	No	1	4	5
292	R:R:V291	R:R:V297	3.21	No	No	1	4	6
293	R:R:D294	R:R:Q296	15.66	No	No	0	2	5
294	R:R:D299	R:R:Q296	2.61	No	No	0	1	5
295	R:R:L298	R:R:Y303	4.69	Yes	Yes	1	1	4
296	R:R:D299	R:R:L300	2.71	No	No	0	1	1
297	R:R:E302	R:R:K301	4.05	No	No	0	3	3
298	R:R:E302	R:R:L305	6.63	No	No	0	3	1
299	R:R:F310	R:R:I306	3.77	No	No	1	6	5
300	R:R:H311	R:R:M315	10.51	Yes	No	1	5	7
301	R:R:C316	R:R:F319	6.98	No	No	0	5	7
302	R:R:F319	R:R:T318	2.59	No	No	0	7	9
303	R:R:R333	R:R:W327	9	No	No	0	8	6
304	R:R:F336	R:R:W327	9.02	Yes	No	0	6	6
305	R:R:N329	R:R:S330	2.98	No	No	3	8	5
306	R:R:N329	R:R:N331	4.09	No	No	3	8	6
307	R:R:N329	R:R:Y332	4.65	No	Yes	3	8	8
308	R:R:N331	R:R:S330	4.47	No	No	3	6	5
309	R:R:F336	R:R:Y332	2.06	Yes	Yes	3	6	8
310	R:R:L337	R:R:R341	7.29	No	No	0	4	3
311	R:R:A90	R:R:V75	1.7	No	No	0	6	7
312	R:R:A133	R:R:V99	1.7	No	No	0	7	7
313	R:R:A320	R:R:V276	1.7	No	No	0	6	6
314	R:R:A278	R:R:V279	1.7	No	No	0	5	6
315	R:R:A56	R:R:I312	1.62	No	No	0	5	5
316	R:R:A172	R:R:I139	1.62	No	No	0	7	5
317	R:R:A339	R:R:K77	1.61	No	No	0	4	5
318	R:R:D197	R:R:P196	1.61	No	No	0	4	3
319	R:R:V51	R:R:V52	1.6	No	No	0	6	5
320	R:R:V271	R:R:V275	1.6	No	No	0	6	4
321	R:R:A177	R:R:L132	1.58	No	No	0	4	5
322	R:R:A180	R:R:L132	1.58	No	No	0	7	5
323	R:R:A177	R:R:L178	1.58	No	No	0	4	4
324	R:R:A278	R:R:L232	1.58	No	Yes	0	5	5
325	R:R:C151	R:R:D147	1.56	No	No	0	8	8
326	R:R:I164	R:R:S161	1.55	No	No	0	5	6
327	R:R:I293	R:R:T217	1.52	No	No	0	4	3
328	R:R:L63	R:R:S59	1.5	No	No	0	6	5
329	R:R:L70	R:R:S69	1.5	No	No	0	7	4
330	R:R:L53	R:R:V49	1.49	No	No	0	5	4
331	R:R:L55	R:R:V51	1.49	No	No	0	6	6
332	R:R:L191	R:R:V201	1.49	No	No	0	3	4
333	R:R:L224	R:R:V229	1.49	No	No	0	5	4
334	R:R:N248	R:R:S244	1.49	No	No	0	4	4
335	R:R:N256	R:R:S251	1.49	No	Yes	0	4	4
336	R:R:L300	R:R:V297	1.49	No	No	0	1	6
337	R:R:L112	R:R:T44	1.47	Yes	No	0	4	4
338	R:R:I160	R:R:I164	1.47	No	No	0	5	5
339	R:R:I164	R:R:I168	1.47	No	No	0	5	5
340	R:R:L246	R:R:T266	1.47	Yes	No	0	8	8
341	R:R:I152	R:R:K245	1.45	No	No	0	8	5
342	R:R:I293	R:R:L289	1.43	No	No	0	4	5
343	R:R:L324	R:R:M328	1.41	Yes	No	0	8	7
344	L:L:H26	R:R:S295	1.39	No	No	0	0	1
345	R:R:A339	R:R:F340	1.39	No	No	0	4	5
346	R:R:D42	R:R:K301	1.38	No	No	0	3	3
347	R:R:E48	R:R:I47	1.37	No	No	0	2	2
348	R:R:I47	R:R:Q50	1.37	No	No	0	2	4
349	R:R:D257	R:R:N256	1.35	No	No	0	4	4
350	R:R:A184	R:R:Y128	1.33	No	No	0	5	6
351	R:R:L179	R:R:Q135	1.33	No	No	0	5	6
352	L:L:R19	L:L:S22	1.32	No	No	0	0	0
353	R:R:F78	R:R:S338	1.32	No	No	0	5	4
354	R:R:R150	R:R:S158	1.32	No	No	0	4	5
355	R:R:F87	R:R:V75	1.31	Yes	No	0	5	7
356	R:R:A172	R:R:W173	1.3	No	Yes	0	7	9
357	R:R:H285	R:R:L224	1.29	Yes	No	0	7	5
358	R:R:R241	R:R:T240	1.29	No	No	0	4	3
359	R:R:S213	R:R:Y215	1.27	No	No	0	2	3
360	L:L:N29	L:L:R25	1.21	Yes	No	0	0	0
361	L:L:R25	R:R:L40	1.21	No	No	0	0	7
362	R:R:H124	R:R:R187	1.13	No	Yes	0	7	6
363	R:R:E157	R:R:Y154	1.12	No	No	0	4	7
364	R:R:F166	R:R:F87	1.07	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P5	3.4925	4	0	0
2	L:L:Y20	6.8125	4	0	0
3	L:L:Y27	2.635	6	5	0
4	L:L:N29	4.075	4	1	0
5	L:L:R33	5.062	5	1	0
6	L:L:Q34	5.908	5	1	0
7	L:L:R35	7.395	6	1	0
8	L:L:?36	4.345	10	1	0
9	R:R:Y57	7.02	5	1	7
10	R:R:N86	4.3925	4	3	8
11	R:R:F87	2.595	4	0	5
12	R:R:F88	4.04	6	2	7
13	R:R:L92	4.708	5	2	9
14	R:R:D96	5.155	4	2	9
15	R:R:L104	4.16	7	1	7
16	R:R:T107	6.8175	4	1	6
17	R:R:Y110	8.7275	4	0	5
18	R:R:L112	3.115	4	0	4
19	R:R:W116	7.746	5	6	8
20	R:R:M118	6.068	5	0	7
21	R:R:V126	5.224	5	0	5
22	R:R:Q130	5.8325	4	1	6
23	R:R:Y149	6.116	5	2	8
24	R:R:I169	4.4075	4	2	7
25	R:R:W173	4.57	6	2	9
26	R:R:F186	5.872	5	7	5
27	R:R:R187	5.3175	4	0	6
28	R:R:E188	7.73	4	0	4
29	R:R:I194	3.6225	4	0	1
30	R:R:W207	4.872	5	7	5
31	R:R:L232	2.635	4	0	5
32	R:R:Y239	3.57889	9	2	9
33	R:R:L246	2.5675	4	4	8
34	R:R:S251	2.645	4	0	4
35	R:R:Y259	5.762	5	4	4
36	R:R:R263	6.278	5	4	7
37	R:R:W281	3.17	6	0	8
38	R:R:H285	2.3575	4	0	7
39	R:R:F287	4.754	5	1	4
40	R:R:L298	5.1475	4	1	1
41	R:R:Y303	5.785	4	1	4
42	R:R:F307	3.1375	4	1	4
43	R:R:H311	7.852	5	1	5
44	R:R:L324	3.7525	4	0	8
45	R:R:Y325	3.87429	7	2	9
46	R:R:Y332	4.19	8	3	8
47	R:R:F336	5.0175	4	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N29	L:L:R25	11.0025	1.21	Yes	No	0	0	0
2	L:L:I31	L:L:Y27	22.3427	2.42	No	Yes	0	0	0
3	L:L:N29	R:R:Y303	11.8592	8.14	Yes	Yes	1	0	4
4	L:L:I31	L:L:T32	26.9887	3.04	No	No	0	0	0
5	L:L:T32	R:R:Y110	27.8948	9.99	No	Yes	0	0	5
6	L:L:R33	L:L:R35	27.8536	5.33	Yes	Yes	1	0	0
7	L:L:?36	L:L:R35	46.7641	8.21	Yes	Yes	1	0	0
8	L:L:?36	L:L:Q34	33.2162	2.25	Yes	Yes	1	0	0
9	L:L:Q34	R:R:Y110	37.604	11.27	Yes	Yes	0	0	5
10	L:L:R33	R:R:Y303	17.9247	4.12	Yes	Yes	1	0	4
11	L:L:R35	R:R:E205	15.0526	11.63	Yes	No	0	0	4
12	R:R:W116	R:R:Y110	15.7775	9.65	Yes	Yes	0	8	5
13	L:L:R35	R:R:Y219	11.2359	9.26	Yes	No	0	0	6
14	L:L:?36	R:R:Q130	23.5509	5.62	Yes	Yes	1	0	6
15	R:R:V126	R:R:W116	12.0487	6.13	Yes	Yes	0	5	8
16	R:R:Q130	R:R:V126	26.6839	4.3	Yes	Yes	0	6	5
17	L:L:?36	R:R:V134	80.8424	3.78	Yes	No	0	0	7
18	L:L:?36	R:R:H311	13.5726	7.61	Yes	Yes	1	0	5
19	R:R:H311	R:R:Y57	20.6293	7.62	Yes	Yes	1	5	7
20	R:R:L108	R:R:Y57	17.2328	11.72	No	Yes	0	6	7
21	R:R:L108	R:R:L112	10.4259	4.15	No	Yes	0	6	4
22	R:R:V134	R:R:W281	80.7573	2.45	No	Yes	0	7	8
23	R:R:S317	R:R:W281	97.3832	2.47	No	Yes	0	9	8
24	R:R:C280	R:R:S317	97.0675	3.44	No	No	0	8	9
25	R:R:C280	R:R:V276	100	1.71	No	No	0	8	6
26	R:R:L324	R:R:V276	99.2916	2.98	Yes	No	0	8	6
27	R:R:L324	R:R:V273	97.8473	7.45	Yes	No	0	8	8
28	R:R:V273	R:R:Y325	68.6043	7.57	No	Yes	2	8	9
29	R:R:L92	R:R:Y325	27.8344	2.34	Yes	Yes	2	9	9
30	R:R:I89	R:R:Y325	31.533	3.63	No	Yes	0	8	9
31	R:R:I89	R:R:Y332	30.6104	9.67	No	Yes	0	8	8
32	R:R:F336	R:R:Y332	12.3809	2.06	Yes	Yes	3	6	8
33	R:R:I144	R:R:Y325	26.2528	4.84	No	Yes	2	9	9
34	R:R:F88	R:R:I144	28.2957	2.51	Yes	No	2	7	9
35	R:R:F88	R:R:I169	11.192	5.02	Yes	Yes	2	7	7
36	R:R:M118	R:R:W116	13.5451	15.12	Yes	Yes	0	7	8
37	R:R:M118	R:R:T109	14.1355	3.01	Yes	No	0	7	4
38	R:R:M113	R:R:T109	10.6181	3.01	No	No	0	4	4
39	R:R:H285	R:R:W281	13.9707	3.17	Yes	Yes	0	7	8
40	R:R:F277	R:R:W281	13.2129	6.01	No	Yes	0	9	8
41	R:R:V273	R:R:Y239	28.8366	3.79	No	Yes	2	8	9
42	R:R:I242	R:R:Y239	27.5433	2.42	No	Yes	0	8	9
43	R:R:E205	R:R:W207	11.991	3.27	No	Yes	0	4	5
44	R:R:F186	R:R:W207	22.5844	8.02	Yes	Yes	7	5	5
45	R:R:W207	R:R:Y219	18.1856	1.93	Yes	No	0	5	6
46	R:R:F186	R:R:Y215	10.1019	2.06	Yes	No	0	5	3
47	R:R:I242	R:R:L246	22.2988	2.85	No	Yes	0	8	8
48	R:R:L246	R:R:Y259	11.2551	3.52	Yes	Yes	4	8	4
49	R:R:M315	R:R:W281	19.391	2.33	No	Yes	0	7	8
50	R:R:L104	R:R:M315	10.2254	7.07	Yes	No	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:E188	10.1	5	No	Yes	0	4	0	1
L:L:Y1	R:R:I192	3.63	5	No	No	0	2	0	1
L:L:P2	R:R:E211	3.14	0	No	No	0	2	0	1
L:L:K4	R:R:E193	6.75	0	No	No	0	2	0	1
L:L:L24	R:R:L40	6.92	0	No	No	0	7	0	1
L:L:L24	R:R:I194	2.85	0	No	Yes	0	1	0	1
L:L:R25	R:R:K301	3.71	0	No	No	0	3	0	1
L:L:H26	R:R:L298	9	1	No	Yes	0	1	0	1
L:L:Y27	R:R:I192	2.42	5	Yes	No	0	2	0	1
L:L:Y27	R:R:I194	2.42	5	Yes	Yes	0	1	0	1
L:L:I28	R:R:I194	2.94	0	No	Yes	0	1	0	1
L:L:N29	R:R:L298	2.75	1	Yes	Yes	0	1	0	1
L:L:N29	R:R:Y303	8.14	1	Yes	Yes	0	4	0	1
L:L:N29	R:R:K304	4.2	1	Yes	No	0	4	0	1
L:L:L30	R:R:L298	4.15	1	No	Yes	0	1	0	1
L:L:I31	R:R:T204	3.04	0	No	No	0	4	0	1
L:L:T32	R:R:Y110	9.99	0	No	Yes	0	5	0	1
L:L:R33	R:R:Q288	4.67	1	Yes	No	0	5	0	1
L:L:R33	R:R:V291	5.23	1	Yes	No	0	4	0	1
L:L:R33	R:R:D292	5.96	1	Yes	No	0	5	0	1
L:L:R33	R:R:Y303	4.12	1	Yes	Yes	0	4	0	1
L:L:Q34	R:R:T107	7.09	1	Yes	Yes	0	6	0	1
L:L:Q34	R:R:Y110	11.27	1	Yes	Yes	0	5	0	1
L:L:Q34	R:R:T111	4.25	1	Yes	No	0	4	0	1
L:L:Q34	R:R:F307	4.68	1	Yes	Yes	0	4	0	1
L:L:R35	R:R:E205	11.63	1	Yes	No	0	4	0	1
L:L:R35	R:R:Y219	9.26	1	Yes	No	0	6	0	1
L:L:R35	R:R:S220	5.27	1	Yes	No	0	4	0	1
L:L:R35	R:R:Q288	4.67	1	Yes	No	0	5	0	1
L:L:?36	R:R:C103	2.68	1	Yes	No	0	6	0	1
L:L:?36	R:R:T107	4.98	1	Yes	Yes	0	6	0	1
L:L:?36	R:R:Q130	5.62	1	Yes	Yes	0	6	0	1
L:L:?36	R:R:G131	2.89	1	Yes	No	0	4	0	1
L:L:?36	R:R:V134	3.78	1	Yes	No	0	7	0	1
L:L:?36	R:R:L183	2.34	1	Yes	No	0	5	0	1
L:L:?36	R:R:F307	3.09	1	Yes	Yes	0	4	0	1
L:L:?36	R:R:H311	7.61	1	Yes	Yes	0	5	0	1
R:R:L104	R:R:Y57	3.52	1	Yes	Yes	7	7	2	2
R:R:H311	R:R:Y57	7.62	1	Yes	Yes	5	7	1	2
R:R:C103	R:R:V99	5.12	1	No	No	6	7	1	2
R:R:C103	R:R:Q130	9.16	1	No	Yes	6	6	1	1
R:R:H311	R:R:L104	2.57	1	Yes	Yes	5	7	1	2
R:R:L104	R:R:M315	7.07	1	Yes	No	7	7	2	2
R:R:Q130	R:R:T107	4.25	1	Yes	Yes	6	6	1	1
R:R:H311	R:R:T107	10.95	1	Yes	Yes	5	6	1	1
R:R:W116	R:R:Y110	9.65	6	Yes	Yes	8	5	2	1
R:R:A202	R:R:Y110	4	0	No	Yes	4	5	2	1
R:R:V126	R:R:W116	6.13	0	Yes	Yes	5	8	2	2
R:R:Q130	R:R:V126	4.3	1	Yes	Yes	6	5	1	2
R:R:G131	R:R:L183	1.71	1	No	No	4	5	1	1
R:R:V134	R:R:W281	2.45	0	No	Yes	7	8	1	2
R:R:L183	R:R:Y219	7.03	1	No	No	5	6	1	1
R:R:E205	R:R:R187	5.82	0	No	Yes	4	6	1	2
R:R:E188	R:R:S190	4.31	0	Yes	No	4	1	1	2
R:R:E188	R:R:T204	7.06	0	Yes	No	4	4	1	1
R:R:E188	R:R:K206	9.45	0	Yes	No	4	3	1	2
R:R:I192	R:R:S190	4.64	5	No	No	2	1	1	2
R:R:F198	R:R:I194	6.28	0	No	Yes	1	1	2	1
R:R:E205	R:R:W207	3.27	0	No	Yes	4	5	1	2
R:R:W207	R:R:Y219	1.93	7	Yes	No	5	6	2	1
R:R:D292	R:R:T217	2.89	0	No	No	5	3	1	2
R:R:D292	R:R:S220	4.42	0	No	No	5	4	1	1
R:R:M315	R:R:W281	2.33	1	No	Yes	7	8	2	2
R:R:F307	R:R:L284	2.44	1	Yes	No	4	6	1	2
R:R:F287	R:R:V291	2.62	1	Yes	No	4	4	2	1
R:R:F287	R:R:V297	2.62	1	Yes	No	4	6	2	2
R:R:F287	R:R:Y303	6.19	1	Yes	Yes	4	4	2	1
R:R:F307	R:R:Q288	2.34	1	Yes	No	4	5	1	1
R:R:V291	R:R:V297	3.21	1	No	No	4	6	1	2
R:R:L298	R:R:Y303	4.69	1	Yes	Yes	1	4	1	1
R:R:E302	R:R:K301	4.05	0	No	No	3	3	2	1
R:R:H311	R:R:M315	10.51	1	Yes	No	5	7	1	2
L:L:H26	R:R:S295	1.39	1	No	No	0	1	0	1
R:R:D42	R:R:K301	1.38	0	No	No	3	3	2	1
L:L:R25	R:R:L40	1.21	0	No	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YOO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.71
Number of Linked Nodes	308
Number of Links	364
Number of Hubs	47
Number of Links mediated by Hubs	193
Number of Communities	7
Number of Nodes involved in Communities	71
Number of Links involved in Communities	99

Path Summary
Number Of Nodes in MetaPath	51
Number Of Links MetaPath	50
Number of Shortest Paths	75790
Length Of Smallest Path	3
Average Path Length	13.1716
Length of Longest Path	28
Minimum Path Strength	1.19
Average Path Strength	4.57579
Maximum Path Strength	12.385
Minimum Path Correlation	0.7
Average Path Correlation	0.939105
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	57.1688
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1246
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • molecular transducer activity • signaling receptor activity • peptide receptor activity • neuropeptide Y receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • channel regulator activity • ion channel regulator activity • calcium channel regulator activity • molecular function regulator activity • transporter regulator activity • peptide YY receptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • behavior • multicellular organismal process • locomotory behavior • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • response to stimulus • signaling • intracellular signal transduction • cell communication • intracellular signaling cassette • cellular process • signal transduction • regulation of cell-substrate adhesion • positive regulation of cell adhesion • regulation of cell adhesion • positive regulation of biological process • cell-substrate adhesion • cell adhesion • positive regulation of cell-substrate adhesion • positive regulation of cellular process • regulation of localization • regulation of transport • transport • secretion • negative regulation of biological process • negative regulation of transport • establishment of localization • regulation of secretion • localization • negative regulation of secretion • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, non-REM sleep • regulation of circadian rhythm • regulation of behavior • circadian sleep/wake cycle, non-REM sleep • regulation of multicellular organismal process • sleep • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • positive regulation of circadian sleep/wake cycle, non-REM sleep • circadian rhythm • circadian behavior • positive regulation of behavior • positive regulation of circadian rhythm • positive regulation of multicellular organismal process • positive regulation of circadian sleep/wake cycle, sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • positive regulation of peptide secretion • nitrogen compound transport • regulation of peptide secretion • regulation of peptide transport • peptide transport • peptide secretion • positive regulation of secretion • positive regulation of transport • amide transport • monoamine transport • regulation of catecholamine secretion • organic hydroxy compound transport • positive regulation of secretion by cell • dopamine transport • positive regulation of amine transport • secretion by cell • regulation of secretion by cell • catecholamine transport • signal release • positive regulation of catecholamine secretion • export from cell • cell-cell signaling • dopamine secretion • positive regulation of dopamine secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • developmental process • heart development • cardiac chamber morphogenesis • heart morphogenesis • animal organ development • circulatory system development • multicellular organism development • anatomical structure morphogenesis • cardiac ventricle morphogenesis • anatomical structure development • cardiac chamber development • animal organ morphogenesis • cardiac left ventricle morphogenesis • cardiac ventricle development • system development • negative regulation of signaling • negative regulation of intracellular signal transduction • regulation of signal transduction • negative regulation of cAMP/PKA signal transduction • negative regulation of cell communication • cAMP/PKA signal transduction • regulation of intracellular signal transduction • negative regulation of cellular process • regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • regulation of cell communication • negative regulation of nervous system process • system process • nervous system process • regulation of system process • regulation of nervous system process • negative regulation of multicellular organismal process • synaptic signaling • synaptic signaling via neuropeptide • modulation of chemical synaptic transmission • synaptic transmission, glutamatergic • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • trans-synaptic signaling • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of smooth muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • modulation of excitatory postsynaptic potential • cell surface receptor signaling pathway • negative regulation of excitatory postsynaptic potential • excitatory postsynaptic potential • regulation of membrane potential • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • negative regulation of feeding behavior • negative regulation of behavior • feeding behavior • regulation of feeding behavior • outflow tract morphogenesis • cell projection • cilium • plasma membrane bounded cell projection • presynapse • non-motile cilium • glutamatergic synapse • protein binding • binding • signaling receptor binding • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide Y receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • neuropeptide signaling pathway • nerve growth factor production • regulation of nerve growth factor production • neurotrophin production • regulation of neurotrophin production • cellular developmental process • central nervous system neuron development • cell development • nervous system development • generation of neurons • central nervous system neuron differentiation • neurogenesis • central nervous system development • neuron differentiation • cell differentiation • neuron development • response to light stimulus • photoperiodism • response to radiation • response to abiotic stimulus • short-day photoperiodism • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • epithelium development • digestive system development • intestinal epithelial cell differentiation • tube development • tissue development • digestive tract development • epithelial cell differentiation • columnar/cuboidal epithelial cell differentiation • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • positive regulation of dopamine metabolic process • regulation of primary metabolic process • amine metabolic process • positive regulation of metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • positive regulation of amine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • regulation of defense response • regulation of acute inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • negative regulation of acute inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • acute inflammatory response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • acute inflammatory response to antigenic stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • regulation of acute inflammatory response • inflammatory response • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • response to chemical • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • head development • forebrain development • brain development • pallium development • cerebral cortex development • telencephalon development • monocyte activation • cell activation • myeloid leukocyte activation • leukocyte activation • regulation of eating behavior • positive regulation of feeding behavior • eating behavior • positive regulation of eating behavior • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • regulation of presynaptic cytosolic calcium ion concentration • cellular homeostasis • neuron cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • cellular localization • regulated exocytosis • synaptic vesicle cycle • synaptic vesicle exocytosis • vesicle-mediated transport • vesicle-mediated transport in synapse • regulation of regulated secretory pathway • establishment of localization in cell • neurotransmitter secretion • regulation of neurotransmitter transport • regulation of synaptic vesicle exocytosis • neurotransmitter transport • regulation of vesicle-mediated transport • signal release from synapse • exocytosis • regulation of neurotransmitter secretion • regulation of exocytosis • adult feeding behavior • adult behavior • plasma membrane bounded cell projection organization • cell projection organization • neuron projection development • cellular component organization • cellular component organization or biogenesis • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • perikaryon • neuronal cell body • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • cytoplasm • neuronal dense core vesicle • axon • neuron projection • axon terminus • distal axon • terminal bouton • neuron projection terminus • GABA-ergic synapse • Golgi apparatus • perinuclear region of cytoplasm • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • establishment of protein localization • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • hormone secretion • protein localization to extracellular region • negative regulation of peptide secretion • negative regulation of protein localization • regulation of establishment of protein localization • regulation of protein transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYC
PDB Residues	L:L:?36
Environment Details	Open EMBL-EBI Page
Code	TYC
Name	L-tyrosinamide
Synonyms	L-tyrosinamide (2S)-2-amino-3-(4-hydroxyphenyl)propanamide L-Tyrosine amide Tyrosinamide Tyrosine amide
Identifier
Formula	C9 H12 N2 O2
Molecular Weight	180.204
SMILES
PubChem	151243
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	25
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49146
Sequence	>7YOO_nogp_Chain_R L I D S T K L I E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F K S M R T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G E W K M G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R Y R C I V Y H L E S K I S K R I S F L I I G L A W G I S A L L A S P L A I F R E Y S L I E I I P D F E I V A C T E K W P G E E K S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G A A N D H Y H Q R R Q K T T K M L V C V V V V F A V C W L P L H A F Q L A V D I D S Q V L D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N Y R K A F L S A F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4MQT	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	-	3.7	2013-11-27	doi.org/10.1038/nature12735
	7T94	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	chim(NtGi1-Go)/β1/γ2	3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T94 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.16	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	6U1N	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	-	LY2119620	Arrestin2	4	2020-02-26	doi.org/10.1038/s41586-020-1954-0
	6OIK	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620	chim(NtGi1-Go)/β1/γ2	3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIK (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Iperoxo	LY2119620		3.6	2019-05-08	doi.org/10.1126/science.aaw5188
	7T96	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620	Go/β1/γ2	3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7T96 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₂	Homo sapiens	Acetylcholine	LY2119620		3.22	2023-01-25	doi.org/10.1038/s41467-022-35726-z
	7V68	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620	Gi1/β1/γ2	3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7V68 (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2119620		3.4	2022-05-11	doi.org/10.1038/s41467-022-30595-y
	7TRP	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298	Gi1/β1/γ2	2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TRP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₄	Homo sapiens	Iperoxo	LY2033298		2.4	2023-05-17	doi.org/10.2139/ssrn.4034884
	7TYH	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYH (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3.3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-	Gs/β1/γ2; RAMP2	3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYY (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Calcitonin-1	-		3	2022-03-23	doi.org/10.1126/science.abm9609
	7TYX	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-	Gs/β1/γ2; RAMP2	2.55	2022-03-30	doi.org/10.1126/science.abm9609
	7TYX (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Amylin	-		2.55	2022-03-30	doi.org/10.1126/science.abm9609
	9BQ3	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-	Gs/β1/γ2; RAMP2	2.8	2025-04-23	To be published
	9BQ3 (No Gprot)	B1	Peptide	Calcitonin	CT (AMY2)	Homo sapiens	Cagrilintide	-		2.8	2025-04-23	To be published
	7WIH	C	Aminoacid	Metabotropic Glutamate	mGlu3; mGlu3	Homo sapiens	LY2794193	-	-	3.68	2022-03-16	doi.org/10.1038/s41422-022-00623-z
	7YON	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-	Gi1/β1/γ2	2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YON (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Peptide-YY(3-36)	-		2.95	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7YOO (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.11	2023-03-22	doi.org/10.1016/j.str.2022.11.010
	7DDZ	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	JNJ-31020028	-	-	2.8	2021-01-27	doi.org/10.1038/s41467-021-21030-9
	7X9B	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-	Gi1/β1/γ2	3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	7X9B (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Neuropeptide-Y	-		3.4	2022-05-18	doi.org/10.1126/sciadv.abm1232
	8K6N	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-	Gi2/β1/γ1	3.2	2024-07-31	doi.org/10.1002/mco2.565
	8K6N (No Gprot)	A	Peptide	Neuropeptide Y	Y₂	Homo sapiens	Pro-neuropeptide-Y	-		3.2	2024-07-31	doi.org/10.1002/mco2.565
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	7Y24	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	Go/β1/γ2	3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y24 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.25	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y26 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Octreotide	-		3.3	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3
	7Y27 (No Gprot)	A	Peptide	Somatostatin	SST2	Homo sapiens	Somatostatin-14	-		3.48	2022-10-19	doi.org/10.1038/s41589-022-01130-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7YOO_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.