Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R42 7.72419
2A:A:M60 5.16254169
3A:A:F212 64169
4A:A:F219 5.425408
5A:A:H220 7.774517
6A:A:F222 9.17417
7A:A:K233 6.146676149
8A:A:F238 9.255409
9A:A:F273 6.7625409
10A:A:W277 10.165236
11A:A:W281 10.3725415
12A:A:F290 4.4625409
13A:A:K293 5.84229
14A:A:F312 4.535408
15A:A:F315 4.708506
16A:A:Y339 4.675403
17A:A:F340 7.588507
18A:A:R342 6.38254244
19A:A:F345 7.3625408
20A:A:S349 3.67407
21A:A:C359 3.8475405
22A:A:Y360 7.768558
23A:A:F363 8.26405
24A:A:F376 5.8385138
25A:A:Q384 4.7925406
26A:A:R385 6.932555
27A:A:L393 3.324258
28B:B:L7 4.5325408
29B:B:L30 5.735405
30B:B:V40 3.5375403
31B:B:H54 10.0865179
32B:B:K57 12.99419
33B:B:W63 7.8425407
34B:B:V71 3.912538
35B:B:Q75 7.23419
36B:B:D76 6.388519
37B:B:L79 4.108537
38B:B:I81 3.985437
39B:B:W82 12.6625409
40B:B:N88 8.19407
41B:B:K89 6.972509
42B:B:I93 5.9525437
43B:B:L95 4.5475438
44B:B:W99 8.835409
45B:B:Y105 3.48606
46B:B:N110 7.9654194
47B:B:Y111 7.03254194
48B:B:N119 3.17409
49B:B:Y124 5.9536
50B:B:Y145 7.1408
51B:B:C149 3.82754188
52B:B:F151 3.81833609
53B:B:L152 3.885403
54B:B:T159 4.0565189
55B:B:D163 7.36254279
56B:B:W169 10.89408
57B:B:F180 8.2375447
58B:B:H183 7.48649
59B:B:V187 4.5975449
60B:B:L190 4.6325405
61B:B:S201 5.36449
62B:B:D205 6.67449
63B:B:K209 7.4775446
64B:B:W211 7.37143748
65B:B:F222 8.256528
66B:B:H225 8.31143729
67B:B:D228 6.28254149
68B:B:I232 5.085428
69B:B:F235 7.34857776
70B:B:F241 8.038526
71B:B:T243 6.188528
72B:B:D246 7.15254149
73B:B:D247 9.65529
74B:B:R251 7.792528
75B:B:F253 5.18429726
76B:B:R256 6.6375409
77B:B:D258 6.4427
78B:B:Q259 3.875406
79B:B:M262 3.8525404
80B:B:Y264 5.908505
81B:B:F278 7.3575407
82B:B:Y289 6.45333607
83B:B:D290 5.905416
84B:B:N295 6.2854156
85B:B:W297 7.67254158
86B:B:R304 6.48754155
87B:B:H311 7.078599
88B:B:R314 11.95418
89B:B:W332 12.546519
90B:B:D333 5.9425499
91B:B:F335 4.5425404
92B:B:L336 5.7254177
93B:B:K337 7.1075496
94B:B:W339 7.6599
95G:G:Y40 10.4475476
96G:G:N59 5.494569
97G:G:P60 8.315469
98G:G:F61 5.96625868
99R:R:D76 8.3325404
100R:R:S82 3.2525405
101R:R:I86 5.56254207
102R:R:V93 2.6975409
103R:R:T100 3.9375406
104R:R:F108 6.5556299
105R:R:L110 4.8825108
106R:R:F129 7.5125287
107R:R:F131 3.1375404
108R:R:Q132 5.69254285
109R:R:V140 2.67404
110R:R:V149 3.4475485
111R:R:V156 4.4975408
112R:R:L174 5.52754136
113R:R:Y176 6.7425408
114R:R:W193 3.6985109
115R:R:L222 4.9325484
116R:R:H226 6.356585
117R:R:F234 4.2754127
118R:R:Y245 5.713336119
119R:R:H255 6.775408
120R:R:F288 4.98509
121R:R:W292 6.417128
122R:R:F295 5.11506
123R:R:Y298 4.388504
124R:R:N321 6.76254129
125R:R:Y329 7.1725119
126R:R:F331 3.43406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N23 B:B:N88 13.37845.45NoYes077
2A:A:N23 B:B:K89 13.53354.2NoYes079
3A:A:L30 B:B:K78 18.48292.82NoNo058
4A:A:L30 B:B:K89 18.32982.82NoYes059
5A:A:K34 B:B:L55 98.6094.23NoNo046
6B:B:D76 B:B:L55 12.32876.79YesNo196
7B:B:D76 B:B:K78 18.94428.3YesNo098
8A:A:K34 A:A:R38 98.58816.19NoNo044
9A:A:Y37 B:B:D76 13.70273.45NoYes149
10A:A:R42 A:A:Y37 10018.52YesNo194
11A:A:R38 R:R:Y177 98.52447.2NoNo045
12A:A:F376 A:A:V214 10.22296.55YesNo1386
13A:A:I372 A:A:V214 11.68164.61NoNo086
14A:A:I372 A:A:Q59 12.65115.49NoNo089
15A:A:N371 A:A:Q59 14.104311.88NoNo099
16A:A:N371 A:A:T364 16.039711.7NoNo099
17A:A:F290 A:A:T364 16.52325.19YesNo099
18A:A:F290 A:A:I288 20.86785.02YesNo099
19A:A:D378 A:A:I288 21.831612.59NoNo079
20A:A:D378 A:A:Y360 22.30639.2NoYes578
21A:A:D381 A:A:Y360 16.45984.6NoYes088
22A:A:Q384 R:R:A173 28.99163.03YesNo068
23A:A:I383 R:R:A173 29.1383.25NoNo088
24A:A:H387 A:A:I383 29.28433.98NoNo088
25A:A:H387 R:R:S169 29.72229.76NoNo089
26R:R:S169 R:R:Y176 94.12587.63NoYes098
27R:R:Y176 R:R:Y177 98.50298.94YesNo085
28A:A:Q384 R:R:H255 18.3738.65YesYes068
29A:A:F222 A:A:R42 28.01394.28YesYes179
30A:A:D240 A:A:R42 71.89423.57NoYes169
31A:A:F238 B:B:W99 19.485912.03YesYes099
32A:A:F222 B:B:W99 28.004713.03YesYes079
33A:A:F345 A:A:V248 17.16626.55YesNo087
34A:A:F246 A:A:V248 17.42655.24NoNo097
35A:A:F246 A:A:L272 17.55647.31NoNo098
36A:A:L272 A:A:R231 17.685310.93NoNo089
37A:A:R231 A:A:W234 17.81494NoNo099
38A:A:F238 A:A:W234 18.20274.01YesNo099
39A:A:Q227 B:B:N119 27.52952.64NoYes099
40A:A:Q227 B:B:Y145 27.92329.02NoYes098
41B:B:L117 B:B:Y145 32.68794.69NoYes098
42B:B:L117 B:B:M101 33.05694.24NoNo099
43A:A:C237 B:B:M101 16.7163.24NoNo189
44A:A:C237 B:B:Q75 16.89726.1NoYes189
45B:B:K57 B:B:Q75 18.61819.49YesYes199
46A:A:D240 B:B:K57 43.45556.91NoYes169
47B:B:M101 B:B:Y59 16.71610.78NoNo198
48B:B:Q75 B:B:Y59 16.89726.76YesNo198
49B:B:Q75 B:B:W99 22.13036.57YesYes099
50A:A:K233 A:A:Q236 25.31538.14YesNo098
51A:A:Q236 A:A:W281 25.49475.48NoYes085
52A:A:W281 B:B:R314 25.744212YesYes158
53B:B:R314 B:B:W332 59.502420.99YesYes189
54A:A:N239 B:B:W332 28.34436.78NoYes189
55A:A:D240 A:A:N239 28.40975.39NoNo168
56B:B:K57 B:B:W332 31.869824.37YesYes199
57A:A:K233 B:B:M188 15.97354.32YesNo1498
58B:B:D290 B:B:R314 32.75218.34YesYes168
59B:B:D290 B:B:G272 10.51811.68YesNo064
60B:B:D246 B:B:G272 10.17131.68YesNo094
61R:R:F108 R:R:T105 18.52335.19YesNo097
62R:R:P106 R:R:T105 18.68015.25NoNo067
63R:R:P106 R:R:Y176 20.0856.95NoYes068
64A:A:Y391 R:R:S169 83.57636.36NoNo049
65A:A:Y391 R:R:R166 83.434918.52NoNo049
66B:B:M188 B:B:S147 16.00953.07NoNo089
67B:B:S147 B:B:S160 15.79784.89NoNo096
68B:B:D228 B:B:S227 18.39155.89YesNo096
69B:B:D247 B:B:S227 17.98584.42YesNo096
70B:B:D247 B:B:H225 15.10888.82YesYes299
71B:B:F253 B:B:H225 12.46063.39YesYes269
72B:B:F222 B:B:F253 14.805111.79YesYes286
73B:B:C271 B:B:D290 24.18434.67NoYes056
74B:B:C271 B:B:D291 23.77933.11NoNo058
75B:B:D291 B:B:Y289 22.5453.45NoYes087
76B:B:I273 B:B:Y289 10.41938.46NoYes067
77B:B:G244 B:B:I273 10.23175.29NoNo056
78B:B:G244 B:B:T243 10.05113.64NoYes058
79B:B:W297 B:B:Y289 11.6993.86YesYes087
80B:B:W297 B:B:Y264 10.863712.54YesYes085
81R:R:F108 R:R:L103 17.104710.96YesNo099
82R:R:L103 R:R:T100 16.94637.37NoYes096
83R:R:P101 R:R:T100 16.47033.5NoYes056
84B:B:F335 R:R:P101 16.15222.89YesNo045
85B:B:L308 B:B:M45 11.36984.24NoNo074
86B:B:M45 G:G:L50 10.70224.24NoNo049
87B:B:D333 B:B:F335 11.66897.17YesYes094
88B:B:D333 B:B:H311 11.01663.78YesYes999
89B:B:D83 B:B:R68 12.112111.91NoNo085
90B:B:D66 B:B:R68 11.55093.57NoNo085
91B:B:D66 B:B:L69 11.22345.43NoNo085
92B:B:L69 B:B:Y105 10.89582.34NoYes056
93B:B:G144 B:B:N119 25.55873.39NoYes089
94B:B:D163 B:B:G144 25.16413.35YesNo098
95B:B:D163 B:B:S161 19.17994.42YesNo2799
96B:B:H142 B:B:S161 18.787112.55NoNo099
97B:B:H142 B:B:L146 18.39097.71NoNo097
98B:B:L146 B:B:T159 15.21664.42NoYes079
99R:R:R166 R:R:Y245 34.65266.17NoYes099
100R:R:M241 R:R:Y245 32.23883.59NoYes1199
101R:R:F288 R:R:M241 32.4053.73YesNo099
102R:R:F288 R:R:V156 31.91457.87YesYes098
103R:R:V156 R:R:W292 30.72683.68YesYes088
104R:R:F152 R:R:W292 27.263110.02NoYes068
105R:R:F152 R:R:L125 25.41212.44NoNo067
106R:R:F129 R:R:L125 22.32142.44YesNo077
107R:R:R166 R:R:Y329 48.729116.46NoYes099
108R:R:L159 R:R:Y329 48.07543.52NoYes089
109R:R:F288 R:R:L159 32.11663.65YesNo098
110R:R:F234 R:R:F288 31.9135.36YesYes079
111R:R:F234 R:R:W292 30.72575.01YesYes1278
112R:R:L159 R:R:N325 15.88148.24NoNo089
113R:R:N321 R:R:N325 15.76549.54YesNo099
114R:R:N321 R:R:W292 15.30565.65YesYes1298
115R:R:F129 R:R:Q132 13.77554.68YesYes2875
116R:R:F295 R:R:W292 48.31029.02YesYes068
117R:R:F295 R:R:L315 17.5738.53YesNo065
118R:R:L315 R:R:L79 16.95524.15NoNo056
119R:R:L79 R:R:S82 16.28173NoYes065
120R:R:I86 R:R:S82 11.90823.1YesYes075
121R:R:Q132 R:R:S141 11.91821.44YesNo059
122R:R:S141 R:R:V140 11.29231.62NoYes094
123R:R:I86 R:R:N90 10.03045.66YesNo2079
124R:R:C299 R:R:F295 21.89392.79NoYes066
125R:R:C299 R:R:V227 21.27093.42NoNo065
126R:R:L222 R:R:V227 19.40112.98YesNo045
127R:R:L222 R:R:V145 11.28284.47YesNo045
128R:R:P221 R:R:V145 10.65735.3NoNo045
129A:A:Y37 B:B:L55 86.3015.86NoNo146
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8TYW
Class A
SubFamily Orphan
Type Orphan
SubType GPR6
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.43
Date 2024-12-04
D.O.I. doi.org/10.2210/pdb8TF5/pdb
Net Summary
Imin 3.03
Number of Linked Nodes 837
Number of Links 950
Number of Hubs 126
Number of Links mediated by Hubs 478
Number of Communities 31
Number of Nodes involved in Communities 177
Number of Links involved in Communities 227
Path Summary
Number Of Nodes in MetaPath 130
Number Of Links MetaPath 129
Number of Shortest Paths 1949935
Length Of Smallest Path 3
Average Path Length 31.0179
Length of Longest Path 53
Minimum Path Strength 1.32
Average Path Strength 6.96612
Maximum Path Strength 22.68
Minimum Path Correlation 0.7
Average Path Correlation 0.986078
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 42.3737
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.4012
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8TYW_Chain_A
KTEDQRNEE KAQREANKK IEKQLQKDK QVYRATHRL LLLGSGKTI 
VKQMRILHT SGIFETKFQ VDKVNFHMF DVGQRDERR KWIQCFNDV 
TAIIFVVAS SSYQTNRLQ ALLFSIWNN WLRSVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTASGD GRHYCYPHF TCAVDTENI RRVFNDCRD IIQRMHLRQ 
YELLNAAKD KDT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8TYW_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8TYW_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP46095
Sequence
>8TYW_Chain_R
VNPWDVLLC VSGTVIAGE NALVVALIA STPALRTPM FVLVGSLAT 
ADLLAGCGL ILHFVFQYL VPSETVSLL TVGFLVASF AASVSSLLA 
ITVDRYLSL YNALTYYSR RTLLGVHLL LAATWTVSL GLGLLPVLG 
WNCLAERAA CSVVRPLAR SHVALLSAA FFMVFGIML HLYVRICQV 
VWRHAHQIA LQQHTRKGV GTLAVVLGT FGASWLPFA IYCVVGSHE 
DPAVYTYAT LLPATYNSM INPIIYAFR NQEIQRALW LLL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TB7AOrphanOrphanGPR61Homo sapiens-PubChem 168510218-2.942023-10-04doi.org/10.1038/s41467-023-41646-3
8T1VAOrphanOrphanGPR6Homo sapiensPubChem 118310209Na-2.62024-12-04doi.org/10.1126/scisignal.ado8741
8T1WAOrphanOrphanGPR6Homo sapiensCVN424--3.492024-12-04doi.org/10.1126/scisignal.ado8741
8TF5AOrphanOrphanGPR6Homo sapiensOleic acid--2.12024-12-04doi.org/10.2210/pdb8TF5/pdb
8TYWAOrphanOrphanGPR6Homo sapiens--Gs/β1/γ23.432024-12-04doi.org/10.2210/pdb8TF5/pdb
8TYW (No Gprot) AOrphanOrphanGPR6Homo sapiens--3.432024-12-04doi.org/10.2210/pdb8TF5/pdb
8TB0AOrphanOrphanGPR61Homo sapiens--chim(NtGi1-Gs)/β1/γ23.472023-10-04doi.org/10.1038/s41467-023-41646-3
8TB0 (No Gprot) AOrphanOrphanGPR61Homo sapiens--3.472023-10-04doi.org/10.1038/s41467-023-41646-3
8KGKAOrphanOrphanGPR61Homo sapiens--Gs/β1/γ23.162023-10-11doi.org/10.1038/s41467-023-41654-3
8KGK (No Gprot) AOrphanOrphanGPR61Homo sapiens--3.162023-10-11doi.org/10.1038/s41467-023-41654-3
9BHLAOrphanOrphanGPR65Homo sapiens--Gs/β12.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHL (No Gprot) AOrphanOrphanGPR65Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHMAOrphanOrphanGPR68Homo sapiens--Gs/β12.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHM (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6AOrphanOrphanGPR68Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
8Z3OAOrphanOrphanGPR68Homo sapiens---3.32025-04-23To be published
8Z5HAOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32025-04-23To be published
8Z5H (No Gprot) AOrphanOrphanGPR68Homo sapiens--3.32025-04-23To be published
8Z68AOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ22.642025-04-23To be published
8Z68 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.642025-04-23To be published
9JFTAOrphanOrphanGPR65Homo sapiens--Gs/β1/γ23.272025-08-13doi.org/10.1038/s41422-025-01092-w
9JFT (No Gprot) AOrphanOrphanGPR65Homo sapiens--3.272025-08-13doi.org/10.1038/s41422-025-01092-w




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8TYW.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.