psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V72	R:R:Y133	8.83	No	No	0	3	5
2	R:R:N73	R:R:P74	6.52	No	No	0	6	4
3	R:R:N73	R:R:W75	5.65	No	No	0	6	5
4	R:R:D76	R:R:N73	5.39	Yes	No	0	4	6
5	R:R:W75	R:R:Y312	7.72	No	No	0	5	4
6	R:R:D76	R:R:F129	9.55	Yes	Yes	0	4	7
7	R:R:D76	R:R:Y133	11.49	Yes	No	0	4	5
8	R:R:D76	R:R:Y312	6.9	Yes	No	0	4	4
9	R:R:L79	R:R:S82	3	Yes	Yes	1	6	5
10	R:R:F129	R:R:L79	7.31	Yes	Yes	1	7	6
11	R:R:L315	R:R:L79	4.15	No	Yes	0	5	6
12	R:R:L79	R:R:T319	2.95	Yes	No	1	6	6
13	R:R:G83	R:R:S82	3.71	No	Yes	0	6	5
14	R:R:I86	R:R:S82	3.1	Yes	Yes	1	7	5
15	R:R:S82	R:R:T319	3.2	Yes	No	1	5	6
16	R:R:I126	R:R:T84	4.56	No	No	0	7	5
17	R:R:M323	R:R:V85	3.04	No	No	0	6	4
18	R:R:I86	R:R:N90	5.66	Yes	No	1	7	9
19	R:R:D118	R:R:I86	4.2	No	Yes	1	9	7
20	R:R:I86	R:R:S322	9.29	Yes	No	1	7	9
21	R:R:D118	R:R:N90	6.73	No	No	1	9	9
22	R:R:N90	R:R:P326	8.15	No	No	0	9	9
23	R:R:L340	R:R:L92	4.15	No	No	0	6	7
24	R:R:A115	R:R:V93	3.39	No	Yes	0	9	9
25	R:R:F331	R:R:V93	3.93	Yes	Yes	0	6	9
26	R:R:L340	R:R:L96	4.15	No	No	0	6	8
27	R:R:I97	R:R:L103	2.85	No	No	4	8	9
28	R:R:F108	R:R:I97	3.77	Yes	No	4	9	8
29	R:R:I336	R:R:I97	2.94	No	No	4	8	8
30	R:R:S99	R:R:T100	3.2	No	Yes	0	4	6
31	R:R:P101	R:R:T100	3.5	No	Yes	0	5	6
32	R:R:L103	R:R:T100	7.37	No	Yes	0	9	6
33	R:R:F108	R:R:L103	10.96	Yes	No	4	9	9
34	R:R:P106	R:R:T105	5.25	No	No	0	6	7
35	R:R:F108	R:R:T105	5.19	Yes	No	0	9	7
36	R:R:P106	R:R:Y176	6.95	No	Yes	0	6	8
37	R:R:L182	R:R:P106	3.28	No	No	0	2	6
38	R:R:F108	R:R:N333	6.04	Yes	No	4	9	8
39	R:R:E335	R:R:F108	5.83	No	Yes	4	7	9
40	R:R:F108	R:R:I336	7.54	Yes	No	4	9	8
41	R:R:L110	R:R:S113	4.5	Yes	No	5	8	9
42	R:R:A161	R:R:L110	3.15	No	Yes	0	7	8
43	R:R:I162	R:R:L110	2.85	No	Yes	0	9	8
44	R:R:D165	R:R:L110	8.14	No	Yes	0	9	8
45	R:R:L110	R:R:V185	4.47	Yes	No	0	8	6
46	R:R:L110	R:R:L189	4.15	Yes	No	5	8	7
47	R:R:L189	R:R:S113	7.51	No	No	5	7	9
48	R:R:L114	R:R:S158	7.51	No	No	0	9	8
49	R:R:I162	R:R:L114	2.85	No	No	0	9	9
50	R:R:D118	R:R:S322	10.31	No	No	1	9	9
51	R:R:F147	R:R:L120	6.09	No	No	0	4	6
52	R:R:A121	R:R:S151	3.42	No	No	0	8	6
53	R:R:F147	R:R:G124	3.01	No	No	0	4	5
54	R:R:L125	R:R:L148	4.15	No	No	0	7	5
55	R:R:F131	R:R:L127	4.87	Yes	No	0	4	7
56	R:R:F129	R:R:H128	13.58	Yes	No	1	7	5
57	R:R:H128	R:R:Q132	9.89	No	Yes	1	5	5
58	R:R:H128	R:R:T144	9.58	No	No	0	5	5
59	R:R:F129	R:R:Q132	4.68	Yes	Yes	1	7	5
60	R:R:Q132	R:R:Y133	6.76	Yes	No	0	5	5
61	R:R:P136	R:R:V135	3.53	No	No	0	3	3
62	R:R:S137	R:R:V135	6.46	No	No	0	6	3
63	R:R:S137	R:R:V140	4.85	No	Yes	0	6	4
64	R:R:E138	R:R:T139	5.64	No	No	0	1	2
65	R:R:L142	R:R:N208	8.24	No	No	0	5	5
66	R:R:L142	R:R:P221	3.28	No	No	0	5	4
67	R:R:L143	R:R:V204	2.98	No	No	0	5	5
68	R:R:P221	R:R:V145	5.3	No	No	0	4	5
69	R:R:L222	R:R:V145	4.47	Yes	No	0	4	5
70	R:R:H226	R:R:V149	4.15	Yes	Yes	2	5	5
71	R:R:L230	R:R:V149	5.96	No	Yes	2	6	5
72	R:R:F152	R:R:S151	3.96	No	No	0	6	6
73	R:R:F152	R:R:W292	10.02	No	Yes	0	6	8
74	R:R:A154	R:R:W193	7.78	No	Yes	5	7	9
75	R:R:A154	R:R:S196	3.42	No	No	5	7	7
76	R:R:S155	R:R:V156	3.23	No	Yes	0	9	8
77	R:R:V156	R:R:V237	3.21	Yes	No	0	8	7
78	R:R:F288	R:R:V156	7.87	Yes	Yes	0	9	8
79	R:R:V156	R:R:W292	3.68	Yes	Yes	0	8	8
80	R:R:S157	R:R:T192	9.59	No	No	0	5	6
81	R:R:F288	R:R:L159	3.65	Yes	No	0	9	8
82	R:R:L159	R:R:N325	8.24	No	No	0	8	9
83	R:R:L159	R:R:Y329	3.52	No	Yes	0	8	9
84	R:R:L160	R:R:V237	5.96	No	No	0	6	7
85	R:R:I240	R:R:L160	5.71	No	No	0	5	6
86	R:R:I162	R:R:Y329	4.84	No	Yes	0	9	9
87	R:R:M241	R:R:T163	9.03	No	No	3	9	9
88	R:R:L244	R:R:T163	4.42	No	No	0	6	9
89	R:R:T163	R:R:Y245	8.74	No	Yes	3	9	9
90	R:R:L244	R:R:V164	2.98	No	No	0	6	6
91	R:R:D165	R:R:Y176	3.45	No	Yes	0	9	8
92	R:R:R166	R:R:Y245	6.17	No	Yes	3	9	9
93	R:R:R166	R:R:Y329	16.46	No	Yes	3	9	9
94	R:R:Y167	R:R:Y171	12.91	No	No	0	8	6
95	R:R:L244	R:R:Y167	4.69	No	No	0	6	8
96	R:R:S169	R:R:Y176	7.63	No	Yes	0	9	8
97	R:R:I248	R:R:L170	4.28	No	No	0	9	9
98	R:R:L170	R:R:V251	2.98	No	No	0	9	6
99	R:R:R247	R:R:Y171	11.32	No	No	0	6	6
100	R:R:V251	R:R:Y171	6.31	No	No	0	6	6
101	R:R:N172	R:R:T175	7.31	No	No	0	5	5
102	R:R:N172	R:R:T181	2.92	No	No	0	5	8
103	R:R:L174	R:R:T175	2.95	No	No	0	6	5
104	R:R:Y176	R:R:Y177	8.94	Yes	No	0	8	5
105	R:R:L182	R:R:R179	4.86	No	No	0	2	4
106	R:R:L183	R:R:R179	7.29	No	No	0	3	4
107	R:R:H186	R:R:L182	5.14	No	No	0	1	2
108	R:R:L188	R:R:T192	2.95	No	No	0	6	6
109	R:R:S196	R:R:W193	4.94	No	Yes	5	7	9
110	R:R:L201	R:R:V204	4.47	No	No	0	5	5
111	R:R:L202	R:R:P203	3.28	No	No	0	5	5
112	R:R:L202	R:R:W207	7.97	No	No	0	5	6
113	R:R:L222	R:R:P203	3.28	Yes	No	2	4	5
114	R:R:H226	R:R:P203	12.2	Yes	No	2	5	5
115	R:R:S225	R:R:W207	9.88	No	No	0	3	6
116	R:R:L210	R:R:N208	6.87	No	No	0	1	5
117	R:R:C209	R:R:C216	7.28	No	No	7	4	9
118	R:R:C209	R:R:R220	2.79	No	Yes	7	4	4
119	R:R:C216	R:R:R213	6.96	No	No	7	9	2
120	R:R:R213	R:R:R220	11.73	No	Yes	7	2	4
121	R:R:H304	R:R:R213	13.54	No	No	0	4	2
122	R:R:C216	R:R:R220	11.14	No	Yes	7	9	4
123	R:R:S217	R:R:V218	3.23	No	No	0	6	4
124	R:R:S217	R:R:V227	8.08	No	No	0	6	5
125	R:R:P221	R:R:R220	2.88	No	Yes	0	4	4
126	R:R:H226	R:R:L222	9	Yes	Yes	2	5	4
127	R:R:L222	R:R:V227	2.98	Yes	No	0	4	5
128	R:R:H226	R:R:L230	3.86	Yes	No	2	5	6
129	R:R:C299	R:R:V227	3.42	No	No	0	6	5
130	R:R:F234	R:R:F235	4.29	Yes	No	6	7	5
131	R:R:F234	R:R:F288	5.36	Yes	Yes	0	7	9
132	R:R:F234	R:R:W292	5.01	Yes	Yes	6	7	8
133	R:R:A296	R:R:F235	4.16	No	No	0	6	5
134	R:R:F238	R:R:F288	4.29	No	Yes	0	6	9
135	R:R:F238	R:R:G289	3.01	No	No	0	6	5
136	R:R:M241	R:R:Y245	3.59	No	Yes	3	9	9
137	R:R:F288	R:R:M241	3.73	Yes	No	0	9	9
138	R:R:H243	R:R:R247	10.16	No	No	0	3	6
139	R:R:L281	R:R:Y245	4.69	No	Yes	0	8	9
140	R:R:V284	R:R:Y245	7.57	No	Yes	3	8	9
141	R:R:L285	R:R:Y245	3.52	No	Yes	0	7	9
142	R:R:Y245	R:R:Y329	2.98	Yes	Yes	3	9	9
143	R:R:Q250	R:R:R247	4.67	No	No	0	3	6
144	R:R:C249	R:R:L281	6.35	No	No	0	6	8
145	R:R:H255	R:R:R254	6.77	No	No	0	8	4
146	R:R:H257	R:R:Q258	4.95	No	No	8	5	3
147	R:R:H257	R:R:L261	3.86	No	No	8	5	3
148	R:R:L261	R:R:Q258	6.65	No	No	8	3	3
149	R:R:K276	R:R:T274	4.5	No	No	0	8	7
150	R:R:R275	R:R:V278	3.92	No	No	0	5	7
151	R:R:I328	R:R:V283	4.61	No	No	0	9	7
152	R:R:I328	R:R:V284	3.07	No	No	3	9	8
153	R:R:V284	R:R:Y329	3.79	No	Yes	3	8	9
154	R:R:N321	R:R:T287	2.92	Yes	No	0	9	7
155	R:R:I324	R:R:T287	4.56	No	No	0	6	7
156	R:R:S291	R:R:W292	3.71	No	Yes	6	8	8
157	R:R:N321	R:R:S291	8.94	Yes	No	6	9	8
158	R:R:F295	R:R:W292	9.02	Yes	Yes	0	6	8
159	R:R:A318	R:R:W292	7.78	No	Yes	0	7	8
160	R:R:N321	R:R:W292	5.65	Yes	Yes	6	9	8
161	R:R:P294	R:R:T314	5.25	No	No	0	9	6
162	R:R:C299	R:R:F295	2.79	No	Yes	0	6	6
163	R:R:F295	R:R:L315	8.53	Yes	No	0	6	5
164	R:R:G302	R:R:Y298	2.9	No	Yes	0	4	4
165	R:R:D306	R:R:Y298	4.6	No	Yes	0	1	4
166	R:R:Y298	R:R:Y310	6.95	Yes	No	0	4	3
167	R:R:T311	R:R:Y298	4.99	No	Yes	0	4	4
168	R:R:E305	R:R:S303	7.19	No	No	0	3	3
169	R:R:E305	R:R:H304	23.39	No	No	0	3	4
170	R:R:D306	R:R:P307	3.22	No	No	0	1	4
171	R:R:P307	R:R:Y310	15.3	No	No	0	4	3
172	R:R:V309	R:R:Y310	7.57	No	No	0	3	3
173	R:R:L316	R:R:P317	3.28	No	No	0	5	7
174	R:R:L316	R:R:T319	4.42	No	No	0	5	6
175	R:R:L316	R:R:Y320	4.69	No	No	0	5	4
176	R:R:N321	R:R:N325	9.54	Yes	No	0	9	9
177	R:R:F331	R:R:I327	5.02	Yes	No	0	6	5
178	R:R:I328	R:R:Y329	7.25	No	Yes	3	9	9
179	R:R:E335	R:R:N333	3.94	No	No	4	7	8
180	R:R:I336	R:R:N333	2.83	No	No	4	8	8
181	R:R:E335	R:R:Q334	5.1	No	No	0	7	4
182	R:R:L343	R:R:L96	2.77	No	No	0	7	8
183	R:R:D165	R:R:M107	2.77	No	No	0	9	8
184	R:R:L183	R:R:L187	2.77	No	No	0	3	3
185	R:R:L199	R:R:L229	2.77	No	No	0	5	5
186	R:R:A308	R:R:Y312	2.67	No	No	0	1	4
187	R:R:F131	R:R:V130	2.62	Yes	No	0	4	5
188	R:R:F131	R:R:V140	2.62	Yes	Yes	0	4	4
189	R:R:F295	R:R:V219	2.62	Yes	No	0	6	4
190	R:R:R332	R:R:T280	2.59	No	No	0	7	9
191	R:R:F295	R:R:T314	2.59	Yes	No	0	6	6
192	R:R:H226	R:R:L199	2.57	Yes	No	0	5	5
193	R:R:T314	R:R:Y298	2.5	No	Yes	0	6	4
194	R:R:F331	R:R:L92	2.44	Yes	No	0	6	7
195	R:R:F129	R:R:L125	2.44	Yes	No	0	7	7
196	R:R:F152	R:R:L125	2.44	No	No	0	6	7
197	R:R:F131	R:R:L134	2.44	Yes	No	0	4	5
198	R:R:F234	R:R:L293	2.44	Yes	No	6	7	4
199	R:R:F235	R:R:L293	2.44	No	No	6	5	4
200	R:R:L168	R:R:Y167	2.34	No	No	0	5	8
201	R:R:E89	R:R:F331	2.33	No	Yes	0	8	6
202	R:R:L78	R:R:W75	2.28	No	No	0	6	5
203	R:R:L189	R:R:W193	2.28	No	Yes	5	7	9
204	R:R:L197	R:R:W193	2.28	No	Yes	0	3	9
205	R:R:L344	R:R:W341	2.28	No	No	0	6	3
206	R:R:G122	R:R:G83	2.11	No	No	0	8	6
207	R:R:G146	R:R:G200	2.11	No	No	2	6	6
208	R:R:A87	R:R:G88	1.95	No	No	0	6	4
209	R:R:A91	R:R:G88	1.95	No	No	0	4	4
210	R:R:A115	R:R:G112	1.95	No	No	0	9	6
211	R:R:A150	R:R:G200	1.95	No	No	0	5	6
212	R:R:G146	R:R:V149	1.84	No	Yes	2	6	5
213	R:R:G200	R:R:V149	1.84	No	Yes	2	6	5
214	R:R:G302	R:R:V301	1.84	No	No	0	4	4
215	R:R:A223	R:R:C209	1.81	No	No	0	5	4
216	R:R:A117	R:R:A154	1.79	No	No	0	8	7
217	R:R:P326	R:R:V93	1.77	No	Yes	0	9	9
218	R:R:G277	R:R:K276	1.74	No	No	0	8	8
219	R:R:G124	R:R:L148	1.71	No	No	0	5	5
220	R:R:A153	R:R:S196	1.71	No	No	0	5	7
221	R:R:G184	R:R:L187	1.71	No	No	0	6	3
222	R:R:A296	R:R:S231	1.71	No	No	0	6	4
223	R:R:G239	R:R:L242	1.71	No	No	0	3	4
224	R:R:C249	R:R:V252	1.71	No	No	0	6	8
225	R:R:G286	R:R:L285	1.71	No	No	0	5	7
226	R:R:A330	R:R:V93	1.7	No	Yes	0	8	9
227	R:R:A330	R:R:V111	1.7	No	No	0	8	7
228	R:R:G206	R:R:N208	1.7	No	No	0	4	5
229	R:R:A102	R:R:T100	1.68	No	Yes	0	6	6
230	R:R:A339	R:R:T100	1.68	No	Yes	0	7	6
231	R:R:A87	R:R:I126	1.62	No	No	0	6	7
232	R:R:S141	R:R:V140	1.62	No	Yes	0	9	4
233	R:R:V300	R:R:V301	1.6	No	No	9	5	4
234	R:R:T84	R:R:V81	1.59	No	No	0	5	4
235	R:R:T116	R:R:V94	1.59	No	No	0	6	7
236	R:R:C123	R:R:L127	1.59	No	No	0	4	7
237	R:R:T139	R:R:V140	1.59	No	Yes	0	2	4
238	R:R:A91	R:R:L119	1.58	No	No	0	4	7
239	R:R:I126	R:R:V130	1.54	No	No	0	7	5
240	R:R:I297	R:R:V300	1.54	No	No	9	5	5
241	R:R:I297	R:R:V301	1.54	No	No	9	5	4
242	R:R:A211	R:R:E212	1.51	No	No	0	3	3
243	R:R:L142	R:R:V204	1.49	No	No	0	5	5
244	R:R:L188	R:R:V164	1.49	No	No	0	6	6
245	R:R:L168	R:R:T181	1.47	No	No	0	5	8
246	R:R:P101	R:R:R104	1.44	No	No	0	5	8
247	R:R:Q132	R:R:S141	1.44	Yes	No	0	5	9
248	R:R:E89	R:R:V85	1.43	No	No	0	8	4
249	R:R:L242	R:R:L285	1.38	No	No	0	4	7
250	R:R:R179	R:R:S178	1.32	No	No	0	4	4
251	R:R:R180	R:R:S178	1.32	No	No	0	6	4
252	R:R:R224	R:R:S303	1.32	No	No	0	4	3
253	R:R:R332	R:R:V283	1.31	No	No	0	7	7
254	R:R:Q262	R:R:Q263	1.28	No	No	0	4	3
255	R:R:T116	R:R:W193	1.21	No	Yes	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D76	8.3325	4	0	4
2	R:R:L79	4.3525	4	1	6
3	R:R:S82	3.2525	4	1	5
4	R:R:I86	5.5625	4	1	7
5	R:R:V93	2.6975	4	0	9
6	R:R:T100	3.486	5	0	6
7	R:R:F108	6.555	6	4	9
8	R:R:L110	4.54333	6	5	8
9	R:R:F129	7.512	5	1	7
10	R:R:F131	3.1375	4	0	4
11	R:R:Q132	5.6925	4	1	5
12	R:R:V140	2.67	4	0	4
13	R:R:V149	3.4475	4	2	5
14	R:R:V156	4.4975	4	0	8
15	R:R:Y176	6.7425	4	0	8
16	R:R:W193	3.698	5	5	9
17	R:R:R220	7.135	4	7	4
18	R:R:L222	4.9325	4	2	4
19	R:R:H226	6.356	5	2	5
20	R:R:F234	4.275	4	6	7
21	R:R:Y245	5.32286	7	3	9
22	R:R:F288	4.98	5	0	9
23	R:R:W292	6.41	7	6	8
24	R:R:F295	5.11	5	0	6
25	R:R:Y298	4.388	5	0	4
26	R:R:N321	6.7625	4	6	9
27	R:R:Y329	6.47333	6	3	9
28	R:R:F331	3.43	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D76	R:R:F129	18.8925	9.55	Yes	Yes	0	4	7
2	R:R:F129	R:R:Q132	36.8166	4.68	Yes	Yes	1	7	5
3	R:R:F129	R:R:L79	15.1352	7.31	Yes	Yes	1	7	6
4	R:R:L79	R:R:S82	37.1646	3	Yes	Yes	1	6	5
5	R:R:L315	R:R:L79	48.4618	4.15	No	Yes	0	5	6
6	R:R:I86	R:R:S82	32.7668	3.1	Yes	Yes	1	7	5
7	R:R:I126	R:R:V130	12.6841	1.54	No	No	0	7	5
8	R:R:F131	R:R:V130	14.4644	2.62	Yes	No	0	4	5
9	R:R:F131	R:R:V140	21.4848	2.62	Yes	Yes	0	4	4
10	R:R:S141	R:R:V140	31.7127	1.62	No	Yes	0	9	4
11	R:R:Q132	R:R:S141	33.3821	1.44	Yes	No	0	5	9
12	R:R:F331	R:R:V93	16.0178	3.93	Yes	Yes	0	6	9
13	R:R:P326	R:R:V93	24.5663	1.77	No	Yes	0	9	9
14	R:R:N90	R:R:P326	26.2457	8.15	No	No	0	9	9
15	R:R:I86	R:R:N90	27.7537	5.66	Yes	No	1	7	9
16	R:R:F108	R:R:T105	29.3323	5.19	Yes	No	0	9	7
17	R:R:P106	R:R:T105	31.5665	5.25	No	No	0	6	7
18	R:R:P106	R:R:Y176	51.0339	6.95	No	Yes	0	6	8
19	R:R:D165	R:R:Y176	57.4289	3.45	No	Yes	0	9	8
20	R:R:D165	R:R:L110	61.6149	8.14	No	Yes	0	9	8
21	R:R:I162	R:R:L110	87.6538	2.85	No	Yes	0	9	8
22	R:R:I162	R:R:Y329	93.4487	4.84	No	Yes	0	9	9
23	R:R:L159	R:R:Y329	100	3.52	No	Yes	0	8	9
24	R:R:F288	R:R:L159	68.1511	3.65	Yes	No	0	9	8
25	R:R:F288	R:R:V156	55.2955	7.87	Yes	Yes	0	9	8
26	R:R:V156	R:R:W292	56.3799	3.68	Yes	Yes	0	8	8
27	R:R:F152	R:R:W292	54.539	10.02	No	Yes	0	6	8
28	R:R:F152	R:R:L125	51.165	2.44	No	No	0	6	7
29	R:R:F129	R:R:L125	45.6072	2.44	Yes	No	0	7	7
30	R:R:F234	R:R:F288	55.2955	5.36	Yes	Yes	0	7	9
31	R:R:F234	R:R:W292	56.3799	5.01	Yes	Yes	6	7	8
32	R:R:L159	R:R:N325	34.5723	8.24	No	No	0	8	9
33	R:R:N321	R:R:N325	34.7034	9.54	Yes	No	0	9	9
34	R:R:N321	R:R:W292	35.5608	5.65	Yes	Yes	6	9	8
35	R:R:F108	R:R:L103	16.3052	10.96	Yes	No	4	9	9
36	R:R:L103	R:R:T100	14.066	7.37	No	Yes	0	9	6
37	R:R:L182	R:R:P106	18.4184	3.28	No	No	0	2	6
38	R:R:L110	R:R:L189	20.698	4.15	Yes	No	5	8	7
39	R:R:L142	R:R:P221	12.4823	3.28	No	No	0	5	4
40	R:R:P221	R:R:V145	29.4785	5.3	No	No	0	4	5
41	R:R:L222	R:R:V145	30.9159	4.47	Yes	No	0	4	5
42	R:R:L222	R:R:V227	50.6254	2.98	Yes	No	0	4	5
43	R:R:C299	R:R:V227	55.114	3.42	No	No	0	6	5
44	R:R:C299	R:R:F295	56.5866	2.79	No	Yes	0	6	6
45	R:R:F295	R:R:L315	49.6167	8.53	Yes	No	0	6	5
46	R:R:H226	R:R:L222	13.4658	9	Yes	Yes	2	5	4
47	R:R:L189	R:R:W193	18.6252	2.28	No	Yes	5	7	9
48	R:R:L244	R:R:T163	30.7898	4.42	No	No	0	6	9
49	R:R:M241	R:R:T163	26.044	9.03	No	No	3	9	9
50	R:R:F288	R:R:M241	40.4731	3.73	Yes	No	0	9	9
51	R:R:M241	R:R:Y245	13.4557	3.59	No	Yes	3	9	9
52	R:R:L244	R:R:Y167	22.5842	4.69	No	No	0	6	8
53	R:R:Y167	R:R:Y171	12.3613	12.91	No	No	0	8	6
54	R:R:L182	R:R:R179	14.0357	4.86	No	No	0	2	4
55	R:R:P221	R:R:R220	15.9724	2.88	No	Yes	0	4	4
56	R:R:F295	R:R:T314	22.8112	2.59	Yes	No	0	6	6
57	R:R:T314	R:R:Y298	19.4119	2.5	No	Yes	0	6	4
58	R:R:F295	R:R:W292	94.8558	9.02	Yes	Yes	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8TYW_nogp

PDB Summary
PDB	8TYW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.79
Number of Linked Nodes	233
Number of Links	255
Number of Hubs	28
Number of Links mediated by Hubs	115
Number of Communities	9
Number of Nodes involved in Communities	52
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	41603
Length Of Smallest Path	3
Average Path Length	14.0289
Length of Longest Path	29
Minimum Path Strength	1.32
Average Path Strength	4.96735
Maximum Path Strength	18.465
Minimum Path Correlation	0.7
Average Path Correlation	0.927576
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	42.9188
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.4453
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46095
Sequence	>8TYW_nogp_Chain_R V N P W D V L L C V S G T V I A G E N A L V V A L I A S T P A L R T P M F V L V G S L A T A D L L A G C G L I L H F V F Q Y L V P S E T V S L L T V G F L V A S F A A S V S S L L A I T V D R Y L S L Y N A L T Y Y S R R T L L G V H L L L A A T W T V S L G L G L L P V L G W N C L A E R A A C S V V R P L A R S H V A L L S A A F F M V F G I M L H L Y V R I C Q V V W R H A H Q I A L Q Q H T R K G V G T L A V V L G T F G A S W L P F A I Y C V V G S H E D P A V Y T Y A T L L P A T Y N S M I N P I I Y A F R N Q E I Q R A L W L L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BI6	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHL	A	Orphan	Orphan	GPR65	Homo sapiens	-	-	Gs/β1	2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHL (No Gprot)	A	Orphan	Orphan	GPR65	Homo sapiens	-	-		2.8	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	Gs/β1	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8TF5	A	Orphan	Orphan	GPR6	Homo sapiens	Oleic acid	-	-	2.1	2024-12-04	10.2210/pdb8TF5/pdb
	8T1W	A	Orphan	Orphan	GPR6	Homo sapiens	CVN424	-	-	3.49	2024-12-04	10.1126/scisignal.ado8741
	8T1V	A	Orphan	Orphan	GPR6	Homo sapiens	PubChem 118310209	Na	-	2.6	2024-12-04	10.1126/scisignal.ado8741
	8TYW	A	Orphan	Orphan	GPR6	Homo sapiens	-	-	Gs/β1/γ2	3.43	2024-12-04	10.2210/pdb8TF5/pdb
	8TYW (No Gprot)	A	Orphan	Orphan	GPR6	Homo sapiens	-	-		3.43	2024-12-04	10.2210/pdb8TF5/pdb
	8TB7	A	Orphan	Orphan	GPR61	Homo sapiens	-	PubChem 168510218	-	2.94	2023-10-04	10.1038/s41467-023-41646-3
	8TB0	A	Orphan	Orphan	GPR61	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.47	2023-10-04	10.1038/s41467-023-41646-3
	8TB0 (No Gprot)	A	Orphan	Orphan	GPR61	Homo sapiens	-	-		3.47	2023-10-04	10.1038/s41467-023-41646-3
	8KGK	A	Orphan	Orphan	GPR61	Homo sapiens	-	-	Gs/β1/γ2	3.16	2023-10-11	10.1038/s41467-023-41654-3
	8KGK (No Gprot)	A	Orphan	Orphan	GPR61	Homo sapiens	-	-		3.16	2023-10-11	10.1038/s41467-023-41654-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8TYW_nogp.zip

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