Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 6.768421920
2M:M:?1 6.417142110
3R:R:I58 5.675467
4R:R:F61 4.16333606
5R:R:V67 4.96536
6R:R:N69 7.62469
7R:R:F71 4.01167638
8R:R:L75 3.56409
9R:R:M82 4.6025427
10R:R:V86 5.46527
11R:R:V87 4.4975427
12R:R:W99 9.25714727
13R:R:F101 8.48167625
14R:R:W105 9.05525
15R:R:E107 6.8875425
16R:R:F108 4.422525
17R:R:W109 5.9325825
18R:R:S111 6.48426
19R:R:I112 4.405424
20R:R:D113 7.7825427
21R:R:L124 4.3275408
22R:R:D130 6.058538
23R:R:R131 5.47167639
24R:R:Y132 5.14438
25R:R:K140 9.125435
26R:R:Y141 10.542537
27R:R:S143 6.4175434
28R:R:L145 4.3125437
29R:R:W158 4.8875409
30R:R:F166 7.896524
31R:R:I169 4.822525
32R:R:W173 4.9275404
33R:R:Y174 7.81725
34R:R:R175 18.2775422
35R:R:H178 6.03422
36R:R:Y185 11.92421
37R:R:F193 6.03524
38R:R:F194 4.28721
39R:R:T195 4.715423
40R:R:Y199 5.52857726
41R:R:F208 11.0775428
42R:R:Y209 5.1975425
43R:R:L212 3.505407
44R:R:Y219 7.21714739
45R:R:V222 4.6675438
46R:R:E225 4.236535
47R:R:K263 8.3075402
48R:R:F264 6.925404
49R:R:H269 9.274535
50R:R:L272 2.984537
51R:R:L275 3.5875438
52R:R:I278 6.9475468
53R:R:M279 5.90667638
54R:R:F282 5.814509
55R:R:W286 5.56375828
56R:R:L287 2.8275406
57R:R:F289 8.386526
58R:R:F290 9.42286727
59R:R:N293 5.085425
60R:R:V297 3.1375405
61R:R:N312 8.8625425
62R:R:W313 4.9125425
63R:R:Y316 6.45143726
64R:R:N322 6.6275469
65R:R:I325 4.81408
66R:R:Y326 7.03569
67R:R:F332 6.022569
68R:R:F336 5.33507
69S:S:M40 2.7925416
70S:S:N51 6.59409
71S:S:V54 3.015409
72S:S:F61 5.58656
73S:S:V67 5.514546
74S:S:N69 8.5375459
75S:S:Y70 6.9375444
76S:S:F71 4.24167648
77S:S:L75 3.58409
78S:S:M82 5.19417
79S:S:V86 4.486517
80S:S:V87 3.402517
81S:S:L95 1.505406
82S:S:W99 9.04571717
83S:S:F101 7.818515
84S:S:W105 7.486515
85S:S:F108 5.705415
86S:S:W109 6.21571715
87S:S:I112 3.4625414
88S:S:L115 4.7125405
89S:S:T118 4.605406
90S:S:D130 5.636548
91S:S:R131 3.57375849
92S:S:Y132 5.745408
93S:S:Y141 10.1675407
94S:S:S143 6.4175444
95S:S:L145 4.67447
96S:S:I154 2.92448
97S:S:W158 3.88833649
98S:S:S161 4.2425408
99S:S:F166 7.414514
100S:S:I169 4.424515
101S:S:W173 5.265404
102S:S:Y174 8.015615
103S:S:R175 17.0025412
104S:S:H178 5.58412
105S:S:D192 5.4725413
106S:S:F193 6.66167614
107S:S:F194 5.80333611
108S:S:T195 5.6075413
109S:S:Y199 5.61429716
110S:S:S204 5.5075415
111S:S:F208 12.4525418
112S:S:Y209 5.59415
113S:S:Y219 6.55625849
114S:S:E225 5.3525105
115S:S:L275 3.23448
116S:S:M279 7.065408
117S:S:F282 6.752509
118S:S:W286 6.3825818
119S:S:F289 8.30667616
120S:S:F290 9.9025817
121S:S:N293 5.214515
122S:S:I294 3.8325416
123S:S:L311 3.3475405
124S:S:N312 9.9825415
125S:S:W313 5.815415
126S:S:Y316 7.15125816
127S:S:N322 6.275459
128S:S:Y326 9.316559
129S:S:F332 6.266559
130S:S:F336 4.29407
131S:S:L339 3.7475456
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:T195 40.40334.83YesYes203
2R:R:T195 R:R:Y199 40.17583.75YesYes236
3R:R:P168 R:R:Y199 98.9322.78NoYes056
4R:R:P168 R:R:W173 99.46514.05NoYes054
5R:R:W173 S:S:A198 99.78153.89YesNo044
6S:S:A198 S:S:N196 99.89043.13NoNo044
7S:S:N196 S:S:Y199 1002.33NoYes046
8S:S:F193 S:S:Y199 32.71983.09YesYes146
9M:M:?1 S:S:F193 33.11983.33YesYes104
10L:L:?1 R:R:S203 40.01043.28YesNo005
11R:R:S203 R:R:Y199 40.177912.72NoYes056
12S:S:T195 S:S:Y199 32.60653.75YesYes136
13M:M:?1 S:S:T195 32.93467.25YesYes103
14S:S:S203 S:S:Y199 32.611713.99NoYes056
15M:M:?1 S:S:S203 32.58372.46YesNo005
16M:M:?1 S:S:W109 11.12297.47YesYes105
17M:M:?1 S:S:W286 40.1992.49YesYes108
18M:M:?1 S:S:Y316 30.56795.12YesYes106
19L:L:?1 R:R:W286 25.2732.49YesYes208
20R:R:F282 R:R:W286 26.36618.02YesYes098
21R:R:F282 R:R:L124 18.33886.09YesYes098
22R:R:I278 R:R:L124 13.8842.85YesYes088
23R:R:I278 R:R:Y326 11.56814.84YesYes689
24S:S:F282 S:S:W286 41.4649.02YesYes098
25S:S:F282 S:S:L124 25.77617.31YesNo098
26S:S:L124 S:S:M279 13.21955.65NoYes088
27S:S:M279 S:S:Y219 11.29959.58YesYes089
28L:L:?1 R:R:W109 15.92127.47YesYes205
29R:R:V222 R:R:Y132 11.02483.79YesYes388
30R:R:R221 R:R:Y132 12.36996.17NoYes058
31S:S:M82 S:S:Y316 22.64393.59YesYes176
32S:S:M82 S:S:S319 22.32326.13YesNo079
33S:S:D79 S:S:S319 21.173810.31NoNo099
34S:S:F282 S:S:S120 13.39322.64YesNo099
35S:S:L75 S:S:S120 13.14243YesNo099
36S:S:L75 S:S:N322 28.73142.75YesYes099
37S:S:N322 S:S:Y326 34.65916.98YesYes599
38S:S:F336 S:S:V54 12.98672.62YesYes079
39S:S:L124 S:S:L75 13.90284.15NoYes089
40S:S:D79 S:S:N322 13.05974.04NoYes099
41S:S:F332 S:S:Y326 22.48039.28YesYes599
42S:S:F336 S:S:L53 14.69538.53YesNo076
43R:R:R221 S:S:K149 12.33012.48NoNo055
44S:S:K149 S:S:T146 12.3266.01NoNo058
45S:S:N148 S:S:T146 12.32154.39NoNo048
46S:S:N148 S:S:R151 12.31941.21NoNo043
47S:S:R151 S:S:Y70 12.320710.29NoYes034
48S:S:I154 S:S:Y70 12.34321.21YesYes484
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:W109 7.47 1 Yes Yes 0 5 0 1
M:M:?1 S:S:D113 14.09 1 Yes No 0 7 0 1
M:M:?1 S:S:V114 9.77 1 Yes No 0 5 0 1
M:M:?1 S:S:V117 6.51 1 Yes No 0 6 0 1
M:M:?1 S:S:T118 2.42 1 Yes Yes 0 6 0 1
M:M:?1 S:S:D192 11.12 1 Yes Yes 0 3 0 1
M:M:?1 S:S:F193 3.33 1 Yes Yes 0 4 0 1
M:M:?1 S:S:F194 5.99 1 Yes Yes 0 1 0 1
M:M:?1 S:S:T195 7.25 1 Yes Yes 0 3 0 1
M:M:?1 S:S:S203 2.46 1 Yes No 0 5 0 1
M:M:?1 S:S:W286 2.49 1 Yes Yes 0 8 0 1
M:M:?1 S:S:F289 5.99 1 Yes Yes 0 6 0 1
M:M:?1 S:S:F290 9.98 1 Yes Yes 0 7 0 1
M:M:?1 S:S:N293 6 1 Yes Yes 0 5 0 1
M:M:?1 S:S:H296 3.51 1 Yes No 0 3 0 1
M:M:?1 S:S:K305 10.02 1 Yes No 0 2 0 1
M:M:?1 S:S:Y308 5.12 1 Yes No 0 5 0 1
M:M:?1 S:S:I309 3.9 1 Yes No 0 3 0 1
M:M:?1 S:S:N312 10.5 1 Yes Yes 0 5 0 1
M:M:?1 S:S:Y316 5.12 1 Yes Yes 0 6 0 1
S:S:M82 S:S:V86 4.56 1 Yes Yes 7 7 2 2
S:S:M82 S:S:Y316 3.59 1 Yes Yes 7 6 2 1
S:S:V86 S:S:W109 2.45 1 Yes Yes 7 5 2 1
S:S:D113 S:S:V86 7.3 1 No Yes 7 7 1 2
S:S:V86 S:S:Y316 5.05 1 Yes Yes 7 6 2 1
S:S:V87 S:S:W313 3.68 1 Yes Yes 7 5 2 2
S:S:V87 S:S:Y316 5.05 1 Yes Yes 7 6 2 1
S:S:F89 S:S:W105 18.04 1 No Yes 5 5 2 2
S:S:F89 S:S:W109 8.02 1 No Yes 5 5 2 1
S:S:G90 S:S:W109 4.22 0 No Yes 7 5 2 1
S:S:H93 S:S:I94 5.3 0 No No 4 5 2 2
S:S:H93 S:S:W99 7.41 0 No Yes 4 7 2 2
S:S:D192 S:S:H93 2.52 1 Yes No 3 4 1 2
S:S:I309 S:S:I94 2.94 1 No No 3 5 1 2
S:S:W105 S:S:W99 3.75 1 Yes Yes 5 7 2 2
S:S:W109 S:S:W99 13.12 1 Yes Yes 5 7 1 2
S:S:C191 S:S:W99 18.28 1 No Yes 9 7 2 2
S:S:W105 S:S:W109 5.62 1 Yes Yes 5 5 2 1
S:S:C191 S:S:W109 2.61 1 No Yes 9 5 2 1
S:S:I169 S:S:T110 4.56 1 Yes No 5 4 2 2
S:S:F193 S:S:T110 14.27 1 Yes No 4 4 1 2
S:S:D113 S:S:Y316 8.05 1 No Yes 7 6 1 1
S:S:S165 S:S:V114 6.46 0 No No 7 5 2 1
S:S:V117 S:S:W286 8.58 1 No Yes 6 8 1 1
S:S:F290 S:S:V117 2.62 1 Yes No 7 6 1 1
S:S:S161 S:S:T118 4.8 0 Yes Yes 8 6 2 1
S:S:S165 S:S:T118 6.4 0 No Yes 7 6 2 1
S:S:S207 S:S:T118 4.8 0 No Yes 5 6 2 1
S:S:I169 S:S:Y174 2.42 1 Yes Yes 5 5 2 2
S:S:F193 S:S:I169 3.77 1 Yes Yes 4 5 1 2
S:S:I169 S:S:Y199 3.63 1 Yes Yes 5 6 2 2
S:S:F193 S:S:Y174 10.32 1 Yes Yes 4 5 1 2
S:S:T195 S:S:Y174 6.24 1 Yes Yes 3 5 1 2
S:S:Y174 S:S:Y199 6.95 1 Yes Yes 5 6 2 2
S:S:A181 S:S:H178 7.32 1 No Yes 4 2 2 2
S:S:F194 S:S:H178 7.92 1 Yes Yes 1 2 1 2
S:S:A181 S:S:Y185 5.34 1 No No 4 1 2 2
S:S:A181 S:S:F194 5.55 1 No Yes 4 1 2 1
S:S:C184 S:S:C190 7.28 0 No No 1 3 2 2
S:S:C184 S:S:F194 5.59 0 No Yes 1 1 2 1
S:S:F194 S:S:Y185 6.19 1 Yes No 1 1 1 2
S:S:C190 S:S:D192 4.67 0 No Yes 3 3 2 1
S:S:D192 S:S:F194 3.58 1 Yes Yes 3 1 1 1
S:S:F193 S:S:T195 5.19 1 Yes Yes 4 3 1 1
S:S:F193 S:S:Y199 3.09 1 Yes Yes 4 6 1 2
S:S:T195 S:S:Y199 3.75 1 Yes Yes 3 6 1 2
S:S:S203 S:S:Y199 13.99 0 No Yes 5 6 1 2
S:S:S204 S:S:Y209 6.36 1 Yes Yes 5 5 2 2
S:S:F290 S:S:S204 6.61 1 Yes Yes 7 5 1 2
S:S:N293 S:S:S204 5.96 1 Yes Yes 5 5 1 2
S:S:I294 S:S:S204 3.1 1 Yes Yes 6 5 2 2
S:S:F208 S:S:Y209 9.28 1 Yes Yes 8 5 2 2
S:S:F208 S:S:F290 33.22 1 Yes Yes 8 7 2 1
S:S:F290 S:S:Y209 3.09 1 Yes Yes 7 5 1 2
S:S:I294 S:S:Y209 3.63 1 Yes Yes 6 5 2 2
S:S:F282 S:S:W286 9.02 0 Yes Yes 9 8 2 1
S:S:F289 S:S:W286 6.01 1 Yes Yes 6 8 1 1
S:S:F290 S:S:W286 6.01 1 Yes Yes 7 8 1 1
S:S:N312 S:S:W286 3.39 1 Yes Yes 5 8 1 1
S:S:G315 S:S:W286 12.67 0 No Yes 7 8 2 1
S:S:W286 S:S:Y316 2.89 1 Yes Yes 8 6 1 1
S:S:F289 S:S:F290 12.86 1 Yes Yes 6 7 1 1
S:S:F289 S:S:N293 3.62 1 Yes Yes 6 5 1 1
S:S:F289 S:S:Y308 9.28 1 Yes No 6 5 1 1
S:S:F289 S:S:N312 12.08 1 Yes Yes 6 5 1 1
S:S:F290 S:S:N293 4.83 1 Yes Yes 7 5 1 1
S:S:I294 S:S:N293 5.66 1 Yes Yes 6 5 2 1
S:S:H296 S:S:N301 20.41 0 No No 3 2 1 2
S:S:H296 S:S:I303 14.58 0 No No 3 3 1 2
S:S:I309 S:S:Y308 2.42 1 No No 3 5 1 1
S:S:N312 S:S:Y316 13.96 1 Yes Yes 5 6 1 1
S:S:W313 S:S:Y316 13.5 1 Yes Yes 5 6 2 1
M:M:?1 S:S:A200 1.72 1 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:H93 3.51 2 Yes No 0 4 0 1
L:L:?1 R:R:W109 7.47 2 Yes Yes 0 5 0 1
L:L:?1 R:R:D113 11.86 2 Yes Yes 0 7 0 1
L:L:?1 R:R:V114 12.21 2 Yes No 0 5 0 1
L:L:?1 R:R:V117 4.07 2 Yes No 0 6 0 1
L:L:?1 R:R:D192 7.42 2 Yes No 0 3 0 1
L:L:?1 R:R:F194 2.66 2 Yes Yes 0 1 0 1
L:L:?1 R:R:T195 4.83 2 Yes Yes 0 3 0 1
L:L:?1 R:R:S203 3.28 2 Yes No 0 5 0 1
L:L:?1 R:R:W286 2.49 2 Yes Yes 0 8 0 1
L:L:?1 R:R:F289 5.32 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 9.32 2 Yes Yes 0 7 0 1
L:L:?1 R:R:N293 9 2 Yes Yes 0 5 0 1
L:L:?1 R:R:H296 4.92 2 Yes No 0 3 0 1
L:L:?1 R:R:K305 9.25 2 Yes No 0 2 0 1
L:L:?1 R:R:Y308 14.09 2 Yes No 0 5 0 1
L:L:?1 R:R:I309 2.34 2 Yes No 0 3 0 1
L:L:?1 R:R:N312 12 2 Yes Yes 0 5 0 1
L:L:?1 R:R:Y316 2.56 2 Yes Yes 0 6 0 1
R:R:M82 R:R:V86 4.56 2 Yes Yes 7 7 2 2
R:R:D113 R:R:M82 2.77 2 Yes Yes 7 7 1 2
R:R:V86 R:R:W109 8.58 2 Yes Yes 7 5 2 1
R:R:D113 R:R:V86 7.3 2 Yes Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 2 Yes Yes 7 6 2 1
R:R:V87 R:R:W313 3.68 2 Yes Yes 7 5 2 2
R:R:V87 R:R:Y316 7.57 2 Yes Yes 7 6 2 1
R:R:F89 R:R:W105 20.04 2 No Yes 5 5 2 2
R:R:F89 R:R:W109 5.01 2 No Yes 5 5 2 1
R:R:G90 R:R:W109 4.22 0 No Yes 7 5 2 1
R:R:H93 R:R:W99 3.17 0 No Yes 4 7 1 2
R:R:I309 R:R:I94 2.94 0 No No 3 5 1 2
R:R:I94 R:R:W313 4.7 0 No Yes 5 5 2 2
R:R:W105 R:R:W99 6.56 2 Yes Yes 5 7 2 2
R:R:W109 R:R:W99 10.31 2 Yes Yes 5 7 1 2
R:R:C191 R:R:W99 14.37 2 No Yes 9 7 2 2
R:R:W105 R:R:W109 5.62 2 Yes Yes 5 5 2 1
R:R:T110 R:R:W109 3.64 0 No Yes 4 5 2 1
R:R:C191 R:R:W109 2.61 2 No Yes 9 5 2 1
R:R:F193 R:R:T110 5.19 2 Yes No 4 4 2 2
R:R:D113 R:R:Y316 9.2 2 Yes Yes 7 6 1 1
R:R:S165 R:R:V114 3.23 0 No No 7 5 2 1
R:R:V117 R:R:W286 4.9 2 No Yes 6 8 1 1
R:R:Y174 R:R:Y185 3.97 2 Yes Yes 5 1 2 2
R:R:F193 R:R:Y174 8.25 2 Yes Yes 4 5 2 2
R:R:T195 R:R:Y174 2.5 2 Yes Yes 3 5 1 2
R:R:Y174 R:R:Y199 5.96 2 Yes Yes 5 6 2 2
R:R:E180 R:R:H178 3.69 2 No Yes 3 2 2 2
R:R:A181 R:R:H178 7.32 2 No Yes 4 2 2 2
R:R:F194 R:R:H178 10.18 2 Yes Yes 1 2 1 2
R:R:E180 R:R:F194 3.5 2 No Yes 3 1 2 1
R:R:A181 R:R:Y185 6.67 2 No Yes 4 1 2 2
R:R:A181 R:R:F194 4.16 2 No Yes 4 1 2 1
R:R:C184 R:R:C190 7.28 0 No No 1 3 2 2
R:R:C184 R:R:F194 2.79 0 No Yes 1 1 2 1
R:R:F194 R:R:Y185 3.09 2 Yes Yes 1 1 1 2
R:R:C190 R:R:D192 6.22 0 No No 3 3 2 1
R:R:D192 R:R:F194 3.58 2 No Yes 3 1 1 1
R:R:F193 R:R:T195 7.78 2 Yes Yes 4 3 2 1
R:R:F193 R:R:Y199 5.16 2 Yes Yes 4 6 2 2
R:R:T195 R:R:Y199 3.75 2 Yes Yes 3 6 1 2
R:R:S203 R:R:Y199 12.72 0 No Yes 5 6 1 2
R:R:S204 R:R:Y209 2.54 2 No Yes 5 5 2 2
R:R:F290 R:R:S204 5.28 2 Yes No 7 5 1 2
R:R:N293 R:R:S204 5.96 2 Yes No 5 5 1 2
R:R:F208 R:R:Y209 9.28 2 Yes Yes 8 5 2 2
R:R:F208 R:R:F290 28.94 2 Yes Yes 8 7 2 1
R:R:F290 R:R:Y209 4.13 2 Yes Yes 7 5 1 2
R:R:F282 R:R:W286 8.02 0 Yes Yes 9 8 2 1
R:R:F289 R:R:W286 6.01 2 Yes Yes 6 8 1 1
R:R:F290 R:R:W286 3.01 2 Yes Yes 7 8 1 1
R:R:N312 R:R:W286 4.52 2 Yes Yes 5 8 1 1
R:R:G315 R:R:W286 12.67 0 No Yes 7 8 2 1
R:R:W286 R:R:Y316 2.89 2 Yes Yes 8 6 1 1
R:R:F289 R:R:F290 12.86 2 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 9.28 2 Yes No 6 5 1 1
R:R:F289 R:R:N312 8.46 2 Yes Yes 6 5 1 1
R:R:F290 R:R:N293 2.42 2 Yes Yes 7 5 1 1
R:R:N293 R:R:V297 2.96 2 Yes Yes 5 5 1 2
R:R:H296 R:R:N301 14.03 0 No No 3 2 1 2
R:R:H296 R:R:I303 11.93 0 No No 3 3 1 2
R:R:I303 R:R:Y308 3.63 0 No No 3 5 2 1
R:R:E306 R:R:I309 2.73 0 No No 2 3 2 1
R:R:N312 R:R:Y316 10.47 2 Yes Yes 5 6 1 1
R:R:W313 R:R:Y316 8.68 2 Yes Yes 5 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8W1V_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.33
Number of Linked Nodes 530
Number of Links 711
Number of Hubs 131
Number of Links mediated by Hubs 474
Number of Communities 11
Number of Nodes involved in Communities 166
Number of Links involved in Communities 285
Path Summary
Number Of Nodes in MetaPath 49
Number Of Links MetaPath 48
Number of Shortest Paths 751651
Length Of Smallest Path 3
Average Path Length 18.1527
Length of Longest Path 33
Minimum Path Strength 1.315
Average Path Strength 5.35567
Maximum Path Strength 26
Minimum Path Correlation 0.7
Average Path Correlation 0.968937
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 49.0102
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.9865
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeA1A
PDB ResiduesL:L:?1 M:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeA1A
Name6-AMINO HEXANOIC ACID
Synonyms
Identifier
FormulaC33 H40 N4 O6
Molecular Weight588.694
SMILES
PubChem5327090
Formal Charge0
Total Atoms83
Total Chiral Atoms4
Total Bonds86
Total Aromatic Bonds18

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>8W1V_poly_Chain_R
IVALCYEKA KTLGIFLWL PFIVYLWIY NSNPLIYLD EVWVVGMGI 
VMSLIVLAI VFGNVLVIT AIAKFERLQ TVTNYFTSL ACADLVMGL 
AVPFGAHIM KMWTFGNFW CEFWTSIDV LCVTASIET LVIAVDRFA 
ITSPFKYQS LLTKNKARV IILMVWIVS GLTSFLPIQ MHWYRATHQ 
EAINCYAET CCDFFTNQA YAIASSIVS FYVPLVIMV FVYSRVFQE 
AKRQLKFCL KHLIMGTTC FVNIVHVIQ DNLIRKEIL NGVGFCRSP 
DFRIAFQEL CLE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-26doi.org/10.1126/science.aaw8981
7XK9AAmineAdrenergicβ2Homo sapiensConstrained IsoproterenolNa-3.42023-04-26doi.org/10.1038/s41467-023-37808-y
6OBAAAmineAdrenergicβ2Homo sapiensS-AlprenololGTPL11074-3.12020-03-25doi.org/10.1038/s41589-020-0549-2
8UO1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; MgGs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8UO4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP; Mg42024-03-06doi.org/10.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GFZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ22.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP2.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ232024-03-06doi.org/10.1038/s41586-024-07153-1
8GG2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG5 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GG9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNLAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNL (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNM (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNN (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNO (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNP (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNQ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNR (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNS (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNT (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNU (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNV (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNW (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNX (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNY (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UNZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO0 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTPGs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8UO2 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained EpinephrineGTP3.62024-03-06doi.org/10.1038/s41586-024-07153-1
5X7DAAmineAdrenergicβ2Homo sapiensS-CarazololCmpd-15-2.72017-08-16doi.org/10.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs(CT)3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
6E67 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.72019-06-05doi.org/10.1016/j.cell.2019.04.021
3D4SAAmineAdrenergicβ2Homo sapiensTimolol--2.82008-06-17doi.org/10.1016/j.str.2008.05.001
3NY8AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-11doi.org/10.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensICI118-551--2.842010-08-11doi.org/10.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiensS-Alprenolol--3.162010-08-11doi.org/10.1021/ja105108q
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-06doi.org/10.1038/nature06325
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-16doi.org/10.1038/nature08650
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-19doi.org/10.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-12doi.org/10.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.22011-07-20doi.org/10.1038/nature10361
3SN6 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.22011-07-20doi.org/10.1038/nature10361
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-25doi.org/10.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-25doi.org/10.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-25doi.org/10.1038/nature12572
5JQHAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.22016-07-13doi.org/10.1038/nature18636
5D6LAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.22016-08-17doi.org/10.1038/nprot.2017.057
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/β1/γ23.822020-08-05doi.org/10.1038/s41421-020-0176-9
7BZ2 (No Gprot) AAmineAdrenergicβ2Homo sapiensArformoterol-3.822020-08-05doi.org/10.1038/s41421-020-0176-9
7XKAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.12023-04-26doi.org/10.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GDZ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE1 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE3 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE4 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE6 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE7 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE8 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GE9 (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEA (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GEB (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEC (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GED (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEE (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.72024-03-06doi.org/10.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEF (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ23.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEG (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-3.82024-03-06doi.org/10.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ242024-03-06doi.org/10.1038/s41586-024-07153-1
8GEH (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-42024-03-06doi.org/10.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEI (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.12024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-Gs/β1/γ24.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GEJ (No Gprot) AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine-4.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.32024-03-06doi.org/10.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.22024-03-06doi.org/10.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.42024-03-06doi.org/10.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.52024-03-06doi.org/10.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.62024-03-06doi.org/10.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--3.92024-03-06doi.org/10.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--42024-03-06doi.org/10.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensConstrained Epinephrine--4.12024-03-06doi.org/10.1038/s41586-024-07153-1
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-14doi.org/10.1038/s41589-018-0145-x
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-06doi.org/10.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-06doi.org/10.1038/s41589-023-01389-0
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/β1/γ23.82019-11-20doi.org/10.1038/s41594-019-0330-y
6NI3 (No Gprot) AAmineAdrenergicβ2Homo sapiensBI167107-3.82019-11-20doi.org/10.1038/s41594-019-0330-y
4QKXAAmineAdrenergicβ2Homo sapiens35V--3.32014-07-23doi.org/10.1073/pnas.1410415111
9CHUAAmineAdrenergicβ2Homo sapiensNoradrenaline--3.492024-11-13doi.org/10.1073/pnas.2414544121
9CHVAAmineAdrenergicβ2Homo sapiens---3.952024-11-13doi.org/10.1073/pnas.2414544121
9CHXAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.52024-11-13doi.org/10.1073/pnas.2414544121
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/β1/γ23.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHI (No Gprot) AAmineAdrenergicβ2Homo sapiensSalbutamol-3.262020-12-16doi.org/10.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/β1/γ23.82020-12-16doi.org/10.1093/nsr/nwaa284
7DHR (No Gprot) AAmineAdrenergicβ2Homo sapiensIsoprenaline-3.82020-12-16doi.org/10.1093/nsr/nwaa284
6PRZAAmineAdrenergicβ2Homo sapiensS-Alprenolol--2.82019-11-13doi.org/10.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiensS-Carazolol--3.42019-11-13doi.org/10.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-13doi.org/10.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiensS-Alprenolol--2.42019-11-13doi.org/10.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiensS-Carvedilol--2.52019-11-13doi.org/10.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI118-551--2.62019-11-13doi.org/10.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiensS-Propranolol--2.92019-11-13doi.org/10.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-13doi.org/10.1107/S2052252519013137
5D5AAAmineAdrenergicβ2Homo sapiensS-Carazolol--2.482016-01-13doi.org/10.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.82016-01-13doi.org/10.1107/S2059798315021683
2RH1AAmineAdrenergicβ2Homo sapiensS-Carazolol--2.42007-10-30doi.org/10.1126/science.1150577
4GBRAAmineAdrenergicβ2Homo sapiensS-Carazolol--3.992012-10-24doi.org/10.1371/journal.pone.0046039
8W1VAAmineAdrenergicβ2Homo sapiensPubChem 171716265--32024-07-17doi.org/10.1021/acs.jmedchem.4c00578
9BUYAAmineAdrenergicβ2Homo sapiensLM189-Gi1/β1/γ22.92025-05-28doi.org/10.1126/sciadv.adq3971
9BUY (No Gprot) AAmineAdrenergicβ2Homo sapiensLM189-2.92025-05-28doi.org/10.1126/sciadv.adq3971




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