Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F9 8.275427
2R:R:Y10 3.974527
3R:R:V11 3.82333628
4R:R:N15 12.7425427
5R:R:V20 9.485426
6R:R:S22 7.4275425
7R:R:P23 7.18625
8R:R:F24 5.89405
9R:R:Q28 8.0825425
10R:R:Y30 6.93624
11R:R:L31 5.582524
12R:R:M44 6.684527
13R:R:M49 3.78167605
14R:R:F52 6.876506
15R:R:N55 6.80754129
16R:R:H65 6.065435
17R:R:L68 5.23637
18R:R:L72 4.88538
19R:R:N73 6.265438
20R:R:N78 7.8225479
21R:R:M86 4.82407
22R:R:F91 5.464527
23R:R:T93 2.29405
24R:R:Y96 8.876554
25R:R:F103 7.85428
26R:R:E113 5.84857725
27R:R:F115 6.86526
28R:R:F116 5.5825404
29R:R:E122 7.076526
30R:R:I123 4.72667677
31R:R:W126 8.035625
32R:R:R135 8.875669
33R:R:Y136 5.5407
34R:R:V138 7.16468
35R:R:T160 5.0975477
36R:R:P170 4.0225427
37R:R:P171 6.535425
38R:R:W175 8.358525
39R:R:R177 9.266525
40R:R:Y178 6.26714723
41R:R:P180 5.6523
42R:R:E181 7.284524
43R:R:M183 6.28402
44R:R:Q184 6.996523
45R:R:C187 5.2675429
46R:R:I189 5.98333624
47R:R:D190 10.316524
48R:R:Y191 7.31333626
49R:R:Y192 6.50833625
50R:R:T193 7.25667625
51R:R:H195 10.66524
52R:R:N200 6.135424
53R:R:F203 8.14429726
54R:R:Y206 10.47424
55R:R:M207 5.2425425
56R:R:H211 8.465626
57R:R:P215 6.8225429
58R:R:M253 4.6775438
59R:R:F261 8.4975409
60R:R:W265 10.405608
61R:R:Y268 11.23426
62R:R:V271 6.2375425
63R:R:I275 5.402524
64R:R:F276 7.295404
65R:R:F283 5.845424
66R:R:P285 3.6025403
67R:R:F287 7.0325424
68R:R:M288 4.456524
69R:R:F293 9.43425
70R:R:K296 6.80833627
71R:R:Y301 8.855405
72R:R:I305 3.2875438
73R:R:Y306 11.988539
74R:R:I307 4.195437
75R:R:M309 5.4375437
76R:R:F313 8.6638
77S:S:F9 8.5475417
78S:S:Y10 4.172517
79S:S:V11 3.82333618
80S:S:N15 10.264517
81S:S:V20 8.386516
82S:S:S22 7.4275415
83S:S:P23 7.18615
84S:S:F24 5.014505
85S:S:Q28 8.0825415
86S:S:Y30 6.93614
87S:S:L31 5.582514
88S:S:M44 6.966517
89S:S:I48 4.2075406
90S:S:M49 6.765405
91S:S:F52 5.5425406
92S:S:N55 6.80754169
93S:S:H65 6.065445
94S:S:L68 5.02547
95S:S:P71 6.0125406
96S:S:L72 5.0625448
97S:S:N73 6.265448
98S:S:Y74 9.16754185
99S:S:N78 7.8225499
100S:S:M86 4.82407
101S:S:F91 5.464517
102S:S:T93 2.29405
103S:S:Y96 8.222554
104S:S:F103 7.85418
105S:S:E113 5.84857715
106S:S:F115 6.86516
107S:S:F116 5.5825404
108S:S:E122 7.322516
109S:S:I123 4.72667697
110S:S:L125 7.005417
111S:S:W126 8.61667615
112S:S:R135 8.875689
113S:S:T160 5.0975497
114S:S:P170 4.0225417
115S:S:P171 5.94515
116S:S:W175 8.358515
117S:S:S176 6.0975415
118S:S:R177 11.1925415
119S:S:Y178 6.26714713
120S:S:P180 5.6513
121S:S:E181 7.958514
122S:S:M183 6.28402
123S:S:Q184 6.996513
124S:S:C187 5.2675419
125S:S:I189 6.22667614
126S:S:D190 12.68414
127S:S:Y191 6.42857716
128S:S:Y192 7.73615
129S:S:T193 8.168515
130S:S:F203 8.29143716
131S:S:Y206 10.0975414
132S:S:M207 5.134515
133S:S:H211 8.724516
134S:S:F212 5.436518
135S:S:P215 6.8225419
136S:S:M253 4.6775448
137S:S:F261 7.442519
138S:S:W265 10.2783608
139S:S:Y268 11.035416
140S:S:V271 6.68415
141S:S:I275 5.886514
142S:S:F276 7.8775414
143S:S:F283 5.845414
144S:S:P285 3.6025403
145S:S:F287 7.0325414
146S:S:M288 4.71167614
147S:S:F293 9.43415
148S:S:K296 6.80833617
149S:S:Y301 8.855405
150S:S:I305 3.2875448
151S:S:Y306 12.69549
152S:S:F313 9.346548
153S:S:C322 2.7075434
154H:H:?1 17.3375420
155H:H:?7 17.96400
156H:H:?10 12.6517610
157L:L:?1 7.869091120
158M:M:?1 7.561210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y268 64.241717.91YesYes206
2R:R:P291 R:R:V271 80.33445.3NoYes065
3R:R:I290 R:R:P291 80.7573.39NoNo056
4R:R:I286 R:R:I290 80.8212.94NoNo015
5R:R:I286 R:R:M183 99.42132.92NoYes012
6R:R:F37 R:R:M183 99.78029.95NoYes052
7R:R:F37 R:R:Y29 99.76038.25NoNo1054
8R:R:P27 R:R:Y29 99.91258.34NoNo084
9R:R:P27 R:R:Y102 99.95638.34NoNo084
10R:R:L31 R:R:P285 19.1084.93YesYes043
11R:R:I286 R:R:P285 18.90023.39NoYes013
12R:R:V104 R:R:Y102 1008.83NoNo044
13R:R:V104 R:R:Y96 50.92395.05NoYes544
14R:R:Y96 S:S:Y96 49.16143.97YesYes544
15S:S:F105 S:S:Y96 95.0310.32NoYes074
16S:S:F105 S:S:G106 94.95191.51NoNo078
17S:S:F24 S:S:G106 94.80221.51YesNo058
18S:S:F103 S:S:F24 75.27335.36YesYes085
19S:S:E113 S:S:F103 74.80943.5YesYes158
20R:R:H100 R:R:V104 49.11966.92NoNo544
21R:R:H100 S:S:Y96 49.1085.44NoYes544
22R:R:I123 R:R:L119 21.05724.28YesNo075
23R:R:I123 R:R:T160 20.26663.04YesYes777
24R:R:S127 R:R:T160 20.17766.4NoYes087
25R:R:I75 R:R:S127 56.39834.64NoNo078
26R:R:I75 R:R:L131 55.29334.28NoNo079
27R:R:L131 R:R:V254 54.92468.94NoNo098
28R:R:R135 R:R:V254 54.55595.23YesNo098
29R:R:R135 R:R:V250 44.481911.77YesNo098
30R:R:L72 R:R:V250 44.10978.94YesNo088
31R:R:L72 R:R:N73 24.73944.12YesYes388
32R:R:N73 R:R:Y306 14.51328.14YesYes389
33R:R:F313 R:R:Y306 12.979324.76YesYes389
34R:R:L72 R:R:L76 15.22344.15YesNo088
35R:R:L76 R:R:Y306 14.489118.76NoYes089
36R:R:I307 R:R:Y306 13.73913.63YesYes379
37L:L:?1 R:R:W265 38.759915.89YesYes008
38R:R:F261 R:R:W265 19.270914.03YesYes098
39R:R:F261 R:R:Y301 18.98954.13YesYes095
40R:R:N302 R:R:Y301 37.106123.26NoYes095
41R:R:L79 R:R:N302 36.85495.49NoNo099
42R:R:C264 R:R:W265 18.742410.45NoYes088
43R:R:C264 R:R:Y301 18.62114.03NoYes085
44L:L:?1 R:R:T118 20.47637.83YesNo004
45R:R:A168 R:R:T118 19.09563.36NoNo074
46R:R:I307 R:R:R314 10.71423.76YesNo378
47S:S:F24 S:S:P180 12.22935.78YesYes053
48M:M:?1 S:S:E113 57.49086.16YesYes105
49S:S:E113 S:S:G114 13.13913.27YesNo055
50S:S:G114 S:S:Y178 12.99785.79NoYes053
51S:S:F115 S:S:Y178 12.75135.16YesYes163
52S:S:F115 S:S:L119 11.67487.31YesNo065
53S:S:I123 S:S:L119 23.21164.28YesNo075
54S:S:I123 S:S:T160 21.46613.04YesYes977
55S:S:S127 S:S:T160 21.19956.4NoYes087
56S:S:I75 S:S:S127 52.89824.64NoNo078
57S:S:I75 S:S:L131 50.70854.28NoNo079
58S:S:L131 S:S:V254 49.97848.94NoNo098
59S:S:R135 S:S:V254 49.24815.23YesNo098
60S:S:R135 S:S:V250 36.03911.77YesNo098
61S:S:L72 S:S:V250 35.30688.94YesNo088
62S:S:L72 S:S:N73 27.2264.12YesYes488
63S:S:N73 S:S:Y306 19.90228.14YesYes489
64S:S:F313 S:S:Y306 13.283124.76YesYes489
65M:M:?1 S:S:T118 12.21968.81YesNo004
66S:S:A168 S:S:T118 11.97433.36NoNo074
67S:S:A168 S:S:L119 11.82653.15NoNo075
68M:M:?1 S:S:F212 13.16428.09YesYes108
69S:S:F212 S:S:F261 11.99583.22YesYes189
70S:S:F261 S:S:Y301 22.83414.13YesYes095
71S:S:N302 S:S:Y301 33.335223.26NoYes095
72S:S:L79 S:S:N302 32.88625.49NoNo099
73S:S:L79 S:S:S127 32.45113NoNo098
74M:M:?1 S:S:W265 24.116915.13YesYes008
75S:S:F261 S:S:W265 12.173314.03YesYes098
76S:S:C264 S:S:W265 11.554110.45NoYes088
77S:S:C264 S:S:Y301 11.40524.03NoYes085
78R:R:L79 R:R:S127 36.60843NoNo098
79R:R:A168 R:R:L119 18.97023.15NoNo075
80R:R:M288 R:R:Y268 67.4795.99YesYes246
81R:R:M288 R:R:V271 71.17086.09YesYes245
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F91 S:S:M44 8.71 1 Yes Yes 7 7 2 2
S:S:M44 S:S:T94 9.03 1 Yes No 7 7 2 2
S:S:K296 S:S:M44 7.2 1 Yes Yes 7 7 1 2
S:S:F91 S:S:K296 3.72 1 Yes Yes 7 7 2 1
S:S:E113 S:S:T94 12.7 1 Yes No 5 7 1 2
S:S:E113 S:S:F103 3.5 1 Yes Yes 5 8 1 2
S:S:C187 S:S:F103 6.98 1 Yes Yes 9 8 2 2
S:S:E113 S:S:G114 3.27 1 Yes No 5 5 1 2
S:S:C187 S:S:E113 3.04 1 Yes Yes 9 5 2 1
S:S:E113 S:S:K296 9.45 1 Yes Yes 5 7 1 1
M:M:?1 S:S:E113 6.16 1 Yes Yes 0 5 0 1
S:S:G114 S:S:Y178 5.79 0 No Yes 5 3 2 2
M:M:?1 S:S:A117 5.23 1 Yes No 0 5 0 1
S:S:A168 S:S:T118 3.36 0 No No 7 4 2 1
S:S:T118 S:S:Y178 8.74 0 No Yes 4 3 1 2
M:M:?1 S:S:T118 8.81 1 Yes No 0 4 0 1
S:S:G121 S:S:W265 5.63 0 No Yes 7 8 2 1
S:S:E122 S:S:L125 3.98 1 Yes Yes 6 7 1 2
S:S:E122 S:S:W126 5.45 1 Yes Yes 6 5 1 2
S:S:C167 S:S:E122 10.64 1 No Yes 5 6 2 1
S:S:E122 S:S:H211 8.62 1 Yes Yes 6 6 1 2
M:M:?1 S:S:E122 7.92 1 Yes Yes 0 6 0 1
S:S:F212 S:S:L125 4.87 1 Yes Yes 8 7 1 2
S:S:F261 S:S:L125 10.96 1 Yes Yes 9 7 2 2
S:S:H211 S:S:W126 3.17 1 Yes Yes 6 5 2 2
S:S:C167 S:S:M207 3.24 1 No Yes 5 5 2 1
S:S:C167 S:S:H211 14.74 1 No Yes 5 6 2 2
S:S:I189 S:S:Y178 6.04 1 Yes Yes 4 3 2 2
S:S:E181 S:S:Y191 5.61 1 Yes Yes 4 6 2 1
S:S:E181 S:S:Y192 13.47 1 Yes Yes 4 5 2 2
S:S:E181 S:S:Y268 10.1 1 Yes Yes 4 6 2 1
S:S:E181 S:S:M288 4.06 1 Yes Yes 4 4 2 2
S:S:F293 S:S:S186 6.61 1 Yes No 5 5 2 1
S:S:K296 S:S:S186 3.06 1 Yes No 7 5 1 1
M:M:?1 S:S:S186 2.99 1 Yes No 0 5 0 1
S:S:I189 S:S:Y191 8.46 1 Yes Yes 4 6 2 1
S:S:F203 S:S:I189 7.54 1 Yes Yes 6 4 2 2
S:S:I189 S:S:M207 7.29 1 Yes Yes 4 5 2 1
S:S:Y191 S:S:Y192 3.97 1 Yes Yes 6 5 1 2
S:S:M207 S:S:Y191 3.59 1 Yes Yes 5 6 1 1
S:S:Y191 S:S:Y268 10.92 1 Yes Yes 6 6 1 1
S:S:A272 S:S:Y191 9.34 0 No Yes 5 6 2 1
M:M:?1 S:S:Y191 3.11 1 Yes Yes 0 6 0 1
S:S:M288 S:S:Y192 5.99 1 Yes Yes 4 5 2 2
S:S:F203 S:S:M207 4.98 1 Yes Yes 6 5 2 1
M:M:?1 S:S:M207 6.57 1 Yes Yes 0 5 0 1
S:S:F212 S:S:L216 9.74 1 Yes No 8 7 1 2
S:S:F212 S:S:F261 3.22 1 Yes Yes 8 9 1 2
M:M:?1 S:S:F212 8.09 1 Yes Yes 0 8 0 1
S:S:F261 S:S:W265 14.03 1 Yes Yes 9 8 2 1
S:S:C264 S:S:W265 10.45 0 No Yes 8 8 2 1
S:S:A295 S:S:W265 7.78 0 No Yes 8 8 2 1
S:S:S298 S:S:W265 8.65 0 No Yes 9 8 2 1
M:M:?1 S:S:W265 15.13 1 Yes Yes 0 8 0 1
S:S:M288 S:S:Y268 5.99 1 Yes Yes 4 6 2 1
M:M:?1 S:S:Y268 17.13 1 Yes Yes 0 6 0 1
S:S:F293 S:S:K296 9.93 1 Yes Yes 5 7 2 1
M:M:?1 S:S:K296 7.49 1 Yes Yes 0 7 0 1
S:S:E113 S:S:T93 2.82 1 Yes Yes 5 5 1 2
M:M:?1 S:S:A269 2.09 1 Yes No 0 7 0 1
S:S:F212 S:S:I213 1.26 1 Yes No 8 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 2 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 9.03 2 Yes No 7 7 2 2
R:R:K296 R:R:M44 7.2 2 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 3.72 2 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 2 Yes No 5 7 1 2
R:R:E113 R:R:F103 3.5 2 Yes Yes 5 8 1 2
R:R:C187 R:R:F103 6.98 2 Yes Yes 9 8 2 2
R:R:E113 R:R:G114 3.27 2 Yes No 5 5 1 2
R:R:C187 R:R:E113 3.04 2 Yes Yes 9 5 2 1
R:R:E113 R:R:K296 9.45 2 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 6.16 2 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 5.79 0 No Yes 5 3 2 2
L:L:?1 R:R:A117 4.19 2 Yes No 0 5 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:T118 R:R:Y178 8.74 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 7.83 2 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 3.98 2 Yes No 6 7 1 2
R:R:E122 R:R:W126 5.45 2 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 10.64 2 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 2 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 7.92 2 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 0 Yes No 9 7 2 2
R:R:H211 R:R:W126 3.17 2 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 16.22 2 No Yes 5 6 2 2
R:R:I189 R:R:Y178 6.04 2 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 5.61 2 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 2 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 4.06 2 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 6.61 2 Yes No 5 5 2 1
R:R:K296 R:R:S186 3.06 2 Yes No 7 5 1 1
L:L:?1 R:R:S186 2.99 2 Yes No 0 5 0 1
R:R:I189 R:R:Y191 8.46 2 Yes Yes 4 6 2 2
R:R:F203 R:R:I189 7.54 2 Yes Yes 6 4 2 2
R:R:I189 R:R:M207 5.83 2 Yes Yes 4 5 2 1
R:R:M207 R:R:Y191 3.59 2 Yes Yes 5 6 1 2
R:R:Y191 R:R:Y268 10.92 2 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 4.98 2 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 6.57 2 Yes Yes 0 5 0 1
R:R:F212 R:R:I213 7.54 0 No No 8 4 1 2
R:R:F212 R:R:L216 4.87 0 No No 8 7 1 2
L:L:?1 R:R:F212 6.47 2 Yes No 0 8 0 1
R:R:F261 R:R:W265 14.03 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 10.45 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?1 R:R:W265 15.89 2 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 5.99 2 Yes Yes 4 6 2 1
L:L:?1 R:R:Y268 17.91 2 Yes Yes 0 6 0 1
L:L:?1 R:R:A269 3.14 2 Yes No 0 7 0 1
R:R:F293 R:R:K296 9.93 2 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 7.49 2 Yes Yes 0 7 0 1
R:R:E113 R:R:T93 2.82 2 Yes Yes 5 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8FCZ_poly
Class A
SubFamily Sensory
Type Opsins
SubType Rhodopsin
Species Bos Taurus
Ligand 11-cis-Retinal
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.7
Date 2023-08-30
D.O.I. 10.1038/s41467-023-40911-9
Net Summary
Imin 2.92
Number of Linked Nodes 605
Number of Links 804
Number of Hubs 158
Number of Links mediated by Hubs 546
Number of Communities 18
Number of Nodes involved in Communities 225
Number of Links involved in Communities 359
Path Summary
Number Of Nodes in MetaPath 82
Number Of Links MetaPath 81
Number of Shortest Paths 1778940
Length Of Smallest Path 3
Average Path Length 34.2603
Length of Longest Path 65
Minimum Path Strength 1.43
Average Path Strength 6.7691
Maximum Path Strength 36.675
Minimum Path Correlation 0.7
Average Path Correlation 0.98362
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 49.8741
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.0796
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?5 H:H:?7 H:H:?8 H:H:?10 H:H:?11 H:H:?15 H:H:?16
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeBMA
PDB ResiduesH:H:?3 H:H:?9 H:H:?12
Environment DetailsOpen EMBL-EBI Page
CodeBMA
Namebeta-D-mannopyranose
Synonymsbeta-D-mannose; D-mannose; mannose
Identifier(2R,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
FormulaC6 H12 O6
Molecular Weight180.156
SMILESC([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
PubChem439680
Formal Charge0
Total Atoms24
Total Chiral Atoms5
Total Bonds24
Total Aromatic Bonds0

CodeMAN
PDB ResiduesH:H:?4 H:H:?6 H:H:?13 H:H:?14
Environment DetailsOpen EMBL-EBI Page
CodeMAN
Namealpha-D-mannopyranose
Synonymsalpha-D-mannose; D-mannose; mannose
Identifier(2S,3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
FormulaC6 H12 O6
Molecular Weight180.156
SMILESC([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
PubChem185698
Formal Charge0
Total Atoms24
Total Chiral Atoms5
Total Bonds24
Total Aromatic Bonds0

CodeRET
PDB ResiduesL:L:?1 M:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeRET
NameRETINAL
Synonyms
Identifier(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal
FormulaC20 H28 O
Molecular Weight284.436
SMILESCC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=O)/C)/C
PubChem638015
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP02699
Sequence
>8FCZ_poly_Chain_R
MNGTEGPNF YVPFSNKTG VVRSPFEAP QYYLAEPWQ FSMLAAYMF 
LLIMLGFPI NFLTLYVTV QHKKLRTPL NYILLNLAV ADLFMVFGG 
FTTTLYTSL HGYFVFGPT GCNLEGFFA TLGGEIALW SLVVLAIER 
YVVVCKPMS NFRNHAIMG VAFTWVMAL ACAAPPLVG WSRYIPEGM 
QCSCGIDYY TPHEETNNE SFVIYMFVV HFIIPLIVI FFCYGQLVF 
TVATTQKAE KEVTRMVII MVIAFLICW LPYAGVAFY IFTHQGSDF 
GPIFMTIPA FFAKTSAVY NPVIYIMMN KQFRNCMVT TLCC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1F88ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82000-08-0410.1126/science.289.5480.739
1GZMASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652003-11-2010.1016/j.jmb.2004.08.090
1HZXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.82001-07-0410.1021/bi0155091
1L9HASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62002-05-1510.1073/pnas.082666399
1U19ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.22004-10-1210.1016/j.jmb.2004.07.044
2G87ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.62006-09-0210.1002/anie.200600595
2HPYASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.82006-08-2210.1073/pnas.0601765103
2I35ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.82006-10-1710.1073/pnas.0608022103
2I36ASensoryOpsinsRhodopsinBos taurus---4.12006-10-1710.1073/pnas.0608022103
2I37ASensoryOpsinsRhodopsinBos taurus---4.152006-10-1710.1073/pnas.0608022103
2J4YASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42007-09-2510.1016/j.jmb.2007.03.007
2PEDASensoryOpsinsRhodopsinBos taurus9-cis-Retinal--2.952007-10-3010.1529/biophysj.107.108225
2X72ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)32011-03-1610.1038/nature09795
2Z73ASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--2.52008-05-1310.1038/nature06925
2ZIYASensoryOpsinsRhodopsinTodarodes pacificus11-cis-Retinal--3.72008-05-0610.1074/jbc.C800040200
3AYMASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-retinal--2.82011-08-1710.1016/j.jmb.2011.08.044
3AYNASensoryOpsinsRhodopsinTodarodes pacificus9-cis-Retinal--2.72011-08-1710.1016/j.jmb.2011.08.044
3C9LASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.652008-08-0510.1107/S0907444908017162
3C9MASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.42008-08-0510.1107/S0907444908017162
3CAPASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
3DQBASensoryOpsinsRhodopsinBos taurus--Gt(CT)3.22008-09-2310.1038/nature07330
3OAXASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--2.62011-01-1910.1016/j.bpj.2010.08.003
3PQRASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)2.852011-03-0910.1038/nature09789
3PXOASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--32011-03-0910.1038/nature09789
4A4MASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)3.32012-01-2510.1073/pnas.1114089108
4BEYASensoryOpsinsRhodopsinBos taurus--Gt(CT)2.92013-05-0810.1038/embor.2013.44
4BEZASensoryOpsinsRhodopsinBos taurus---3.32013-04-2410.1038/embor.2013.44
4J4QASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)2.652013-10-3010.1002/anie.201302374
4PXFASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop2.752014-09-1710.1038/ncomms5801
4WW3ASensoryOpsinsRhodopsinTodarodes pacificusAll-trans-retinal--2.82015-06-1710.1371/journal.pone.0126970
4X1HASensoryOpsinsRhodopsinBos taurusNonyl Beta-D-Glucopyranoside-Gt(CT)2.292015-11-0410.1016/j.str.2015.09.015
4ZWJASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.32015-07-2910.1038/nature14656
5DGYASensoryOpsinsRhodopsinHomo sapiens--Arrestin17.72016-03-2310.1038/sdata.2016.21
5DYSASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--2.32016-08-1010.15252/embr.201642671
5EN0ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt(CT)2.812016-08-1010.15252/embr.201642671
5TE3ASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside--2.72017-03-1510.1073/pnas.1617446114
5TE5ASensoryOpsinsRhodopsinBos taurus20-Methanoretinal--4.012017-03-1510.1073/pnas.1617446114
5W0PASensoryOpsinsRhodopsinHomo sapiens--Arrestin13.012017-08-0910.1016/j.cell.2017.07.002
5WKTASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)3.22017-12-1310.1038/nprot.2017.135
6CMOASensoryOpsinsRhodopsinHomo sapiens--Gi1/&β;1/&γ;24.52018-06-2010.1038/s41586-018-0215-y
6FK6ASensoryOpsinsRhodopsinBos taurus-PubChem 132473033-2.362018-04-0410.1073/pnas.1718084115
6FK7ASensoryOpsinsRhodopsinBos taurus-PubChem 132473034-2.622018-04-0410.1073/pnas.1718084115
6FK8ASensoryOpsinsRhodopsinBos taurus-PubChem 132473035-2.872018-04-0410.1073/pnas.1718084115
6FK9ASensoryOpsinsRhodopsinBos taurus-PubChem 132473036-2.632018-04-0410.1073/pnas.1718084115
6FKAASensoryOpsinsRhodopsinBos taurus-PubChem 132473037-2.72018-04-0410.1073/pnas.1718084115
6FKBASensoryOpsinsRhodopsinBos taurus-PubChem 132473038-3.032018-04-0410.1073/pnas.1718084115
6FKCASensoryOpsinsRhodopsinBos taurus-PubChem 132473039-2.462018-04-0410.1073/pnas.1718084115
6FKDASensoryOpsinsRhodopsinBos taurus-PubChem 137349183-2.492018-04-0410.1073/pnas.1718084115
6FUFASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Go/&β;1/&γ;23.122018-10-0310.1126/sciadv.aat7052
6I9KASensoryOpsinsRhodopsinHasarius adansoni9-cis-Retinal--2.152019-07-0310.1073/pnas.1902192116
6NWEASensoryOpsinsRhodopsinBos taurusOctyl Beta-D-Glucopyranoside-Gt(CT)2.712020-02-12To be published
6OFJASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
6OY9ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt/&β;1/&γ;13.92019-07-2410.1016/j.molcel.2019.06.007
6OYAASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gt/&β;1/&γ;13.32019-07-2410.1016/j.molcel.2019.06.007
6PELASensoryOpsinsRhodopsinBos taurus-CitronellolGt(CT)3.192020-06-24To be published
6PGSASensoryOpsinsRhodopsinBos taurus-GeraniolGt(CT)2.92020-07-01To be published
6PH7ASensoryOpsinsRhodopsinBos taurus-NerolGt(CT)2.92020-07-01To be published
6QNOASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-Gi1/&β;1/&γ;14.382019-07-1010.7554/eLife.46041
7MT8ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK15.82021-07-0710.1038/s41586-021-03721-x
7MT9ASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK172021-07-0710.1038/s41586-021-03721-x
7MTAASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK14.12021-07-0710.1038/s41586-021-03721-x
7MTBASensoryOpsinsRhodopsinBos taurusAll-trans-retinal-GRK142021-07-0710.1038/s41586-021-03721-x
7ZBCASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
7ZBEASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6CASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6DASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8A6EASensoryOpsinsRhodopsinBos taurusAll-trans-retinal--1.82023-03-2910.1038/s41586-023-05863-6
8FCZASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FD0ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD1ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9
3CAP (Dimer)ASensoryOpsinsRhodopsinBos taurus---2.92008-06-2410.1038/nature07063
6OFJ (Dimer)ASensoryOpsinsRhodopsinBos taurus---4.52019-08-2110.1074/jbc.RA119.010089
8FCZ (Dimer)ASensoryOpsinsRhodopsinBos taurus11-cis-Retinal--3.72023-08-3010.1038/s41467-023-40911-9
8FD0 (Dimer)ASensoryOpsinsRhodopsinBos taurus---3.712023-08-3010.1038/s41467-023-40911-9
8FD1 (Dimer)ASensoryOpsinsRhodopsinBos taurus---4.252023-08-3010.1038/s41467-023-40911-9




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