psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I24	R:R:N19	5.66	No	No	0	7	1
2	R:R:E20	R:R:P21	3.14	No	No	3	4	6
3	R:R:E20	R:R:P22	9.43	No	No	3	4	4
4	R:R:E20	R:R:V23	5.7	No	No	0	4	4
5	R:R:P21	R:R:P22	5.84	No	No	3	6	4
6	R:R:P22	R:R:W416	4.05	No	Yes	0	4	7
7	R:R:L82	R:R:V23	4.47	No	No	0	7	4
8	R:R:I29	R:R:L25	5.71	No	No	0	7	5
9	R:R:L25	R:R:V419	4.47	No	No	0	5	5
10	R:R:S26	R:R:V419	3.23	No	No	0	8	5
11	R:R:L32	R:R:V28	2.98	No	No	0	6	6
12	R:R:A422	R:R:I29	3.25	No	No	0	8	7
13	R:R:L30	R:R:S78	3	No	No	0	6	8
14	R:R:L30	R:R:L79	5.54	No	No	0	6	6
15	R:R:A422	R:R:L30	3.15	No	No	0	8	6
16	R:R:F34	R:R:L38	6.09	No	Yes	0	7	7
17	R:R:F34	R:R:L75	6.09	No	No	0	7	9
18	R:R:F34	R:R:P76	5.78	No	No	0	7	9
19	R:R:C429	R:R:G37	3.92	No	No	0	9	9
20	R:R:L38	R:R:P39	8.21	Yes	No	0	7	7
21	R:R:D68	R:R:N41	8.08	Yes	No	0	9	9
22	R:R:N41	R:R:P432	13.03	No	No	0	9	9
23	R:R:L43	R:R:V47	2.98	No	No	0	8	8
24	R:R:T65	R:R:V44	3.17	No	No	0	9	9
25	R:R:L437	R:R:V44	2.98	No	No	0	7	9
26	R:R:F442	R:R:V44	6.55	Yes	No	0	9	9
27	R:R:L45	R:R:T65	10.32	No	No	0	8	9
28	R:R:L50	R:R:W46	9.11	No	No	0	4	6
29	R:R:K51	R:R:W46	4.64	No	No	0	9	6
30	R:R:F442	R:R:V47	3.93	Yes	No	0	9	8
31	R:R:S449	R:R:V47	6.46	No	No	0	9	8
32	R:R:A48	R:R:L62	3.15	No	No	0	7	8
33	R:R:G49	R:R:L62	3.42	No	No	0	7	8
34	R:R:K51	R:R:S449	6.12	No	No	0	9	9
35	R:R:M52	R:R:Q53	4.08	Yes	No	0	9	6
36	R:R:M52	R:R:T58	3.01	Yes	No	0	9	8
37	R:R:F442	R:R:M52	6.22	Yes	Yes	0	9	9
38	R:R:I59	R:R:R54	3.76	No	No	0	6	7
39	R:R:T55	R:R:T58	6.28	No	No	0	9	8
40	R:R:R134	R:R:V56	15.69	Yes	No	0	9	8
41	R:R:N57	R:R:R134	6.03	No	Yes	0	8	9
42	R:R:L62	R:R:T58	2.95	No	No	0	8	8
43	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
44	R:R:I116	R:R:W60	8.22	No	Yes	0	9	8
45	R:R:I142	R:R:W60	3.52	No	Yes	0	5	8
46	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
47	R:R:C143	R:R:H63	14.74	No	No	0	8	8
48	R:R:H63	R:R:W147	5.29	No	No	0	8	9
49	R:R:D68	R:R:L64	8.14	Yes	Yes	1	9	9
50	R:R:L113	R:R:L64	5.54	No	Yes	1	8	9
51	R:R:L64	R:R:N431	6.87	Yes	Yes	1	9	9
52	R:R:L64	R:R:Y435	3.52	Yes	Yes	1	9	9
53	R:R:L66	R:R:L70	5.54	No	No	0	4	6
54	R:R:D68	R:R:S428	7.36	Yes	No	0	9	9
55	R:R:D68	R:R:N431	10.77	Yes	Yes	1	9	9
56	R:R:L69	R:R:L73	5.54	No	No	4	7	8
57	R:R:L70	R:R:N105	6.87	No	No	0	6	9
58	R:R:C71	R:R:N105	4.72	No	No	0	8	9
59	R:R:C71	R:R:S428	6.89	No	No	0	8	9
60	R:R:C72	R:R:L75	3.17	No	No	0	8	9
61	R:R:C72	R:R:S428	3.44	No	No	0	8	9
62	R:R:F77	R:R:S74	5.28	No	No	0	8	9
63	R:R:I102	R:R:S74	6.19	No	No	0	8	9
64	L:L:?1	R:R:S78	12.39	Yes	No	0	0	8
65	R:R:G86	R:R:H81	3.18	No	No	0	7	7
66	R:R:H81	R:R:W88	9.52	No	Yes	0	7	9
67	L:L:?1	R:R:H81	20.33	Yes	No	0	0	7
68	R:R:H418	R:R:L82	3.86	No	No	0	4	7
69	R:R:W88	R:R:Y90	11.58	Yes	No	0	9	7
70	R:R:L94	R:R:W88	5.69	No	Yes	0	8	9
71	R:R:I98	R:R:W88	3.52	No	Yes	0	8	9
72	R:R:P89	R:R:Y90	4.17	No	No	0	8	7
73	R:R:I163	R:R:R92	6.26	No	No	0	6	1
74	R:R:C172	R:R:C95	7.28	Yes	No	0	8	9
75	R:R:I101	R:R:L97	7.14	No	No	0	5	6
76	R:R:I98	R:R:P99	3.39	No	No	0	8	8
77	L:L:?1	R:R:I98	5.89	Yes	No	0	0	8
78	R:R:P99	R:R:R161	11.53	No	Yes	0	8	8
79	R:R:C154	R:R:S100	3.44	No	No	0	8	8
80	R:R:S100	R:R:V157	3.23	No	No	0	8	9
81	R:R:F158	R:R:S100	3.96	No	No	0	8	8
82	R:R:I101	R:R:N105	4.25	No	No	0	5	9
83	R:R:I102	R:R:M106	4.37	No	No	0	8	9
84	L:L:?1	R:R:I102	3.93	Yes	No	0	0	8
85	R:R:V103	R:R:V157	6.41	No	No	0	5	9
86	L:L:?1	R:R:V103	3.07	Yes	No	0	0	5
87	R:R:C154	R:R:L104	4.76	No	No	0	8	8
88	R:R:M106	R:R:W390	6.98	No	Yes	0	9	9
89	R:R:M106	R:R:S425	3.07	No	No	0	9	8
90	R:R:F107	R:R:F111	5.36	No	No	0	8	8
91	R:R:F107	R:R:M153	4.98	No	No	0	8	8
92	R:R:F107	R:R:R340	7.48	No	No	0	8	0
93	R:R:A108	R:R:W147	5.19	No	No	0	9	9
94	R:R:P348	R:R:V110	3.53	Yes	No	0	0	9
95	R:R:F386	R:R:V110	3.93	Yes	No	1	9	9
96	R:R:V110	R:R:W390	8.58	No	Yes	1	9	9
97	R:R:F111	R:R:I146	7.54	No	No	0	8	8
98	R:R:F111	R:R:V149	5.24	No	No	0	8	4
99	R:R:I146	R:R:L112	4.28	No	No	0	8	9
100	R:R:L113	R:R:N431	8.24	No	Yes	1	8	9
101	R:R:L113	R:R:Y435	16.41	No	Yes	1	8	9
102	R:R:S117	R:R:T114	3.2	No	Yes	1	9	8
103	R:R:P348	R:R:T114	6.99	Yes	Yes	0	0	8
104	R:R:I351	R:R:T114	3.04	No	Yes	0	0	8
105	R:R:M352	R:R:T114	6.02	Yes	Yes	1	0	8
106	R:R:I116	R:R:R120	6.26	No	No	1	9	9
107	R:R:I116	R:R:Y435	3.63	No	Yes	1	9	9
108	R:R:M352	R:R:S117	7.67	Yes	No	1	0	9
109	R:R:S117	R:R:Y356	3.82	No	Yes	1	9	0
110	R:R:L118	R:R:L122	5.54	No	No	0	8	7
111	R:R:D119	R:R:V123	4.38	No	No	5	9	5
112	R:R:D119	R:R:R134	14.29	No	Yes	5	9	9
113	R:R:R120	R:R:Y435	6.17	No	Yes	1	9	9
114	R:R:C121	R:R:C355	7.28	No	No	0	9	0
115	R:R:C121	R:R:I359	3.27	No	No	0	9	0
116	R:R:C130	R:R:V123	5.12	No	No	0	7	5
117	R:R:R134	R:R:V123	3.92	Yes	No	5	9	5
118	R:R:R362	R:R:V124	3.92	No	No	0	0	9
119	R:R:F125	R:R:F358	7.5	No	No	0	6	0
120	R:R:I128	R:R:K126	5.82	No	No	0	7	6
121	R:R:I128	R:R:P127	3.39	No	No	0	7	9
122	R:R:H133	R:R:W129	23.27	No	No	0	8	6
123	R:R:N132	R:R:Q131	9.24	No	No	0	8	9
124	R:R:H133	R:R:N132	3.83	No	No	0	8	8
125	R:R:G137	R:R:N135	3.39	No	No	0	5	5
126	R:R:M138	R:R:S141	3.07	No	No	0	6	2
127	R:R:F151	R:R:I155	6.28	No	No	0	5	5
128	R:R:I155	R:R:P156	3.39	No	No	0	5	9
129	R:R:V159	R:R:Y160	3.79	No	Yes	0	4	8
130	R:R:I336	R:R:Y160	4.84	No	Yes	0	0	8
131	R:R:C172	R:R:R161	5.57	Yes	Yes	2	8	8
132	R:R:G173	R:R:R161	6	No	Yes	0	1	8
133	R:R:R161	R:R:Y174	12.35	Yes	No	2	8	7
134	L:L:?1	R:R:R161	5.01	Yes	Yes	2	0	8
135	R:R:I163	R:R:N170	4.25	No	No	0	6	4
136	L:L:?1	R:R:C172	3.27	Yes	Yes	2	0	8
137	L:L:?1	R:R:Y174	8.87	Yes	No	2	0	7
138	R:R:L401	R:R:V334	4.47	No	No	0	7	0
139	R:R:L401	R:R:T337	5.9	No	No	0	7	0
140	R:R:R340	R:R:Y393	4.12	No	Yes	0	0	9
141	R:R:F345	R:R:L341	4.87	Yes	No	2	0	0
142	R:R:H394	R:R:L341	3.86	No	No	2	9	0
143	R:R:G344	R:R:P348	4.06	No	Yes	0	0	0
144	R:R:F345	R:R:L346	3.65	Yes	No	0	0	0
145	R:R:F345	R:R:T391	6.49	Yes	Yes	0	0	6
146	R:R:F345	R:R:H394	20.36	Yes	No	2	0	9
147	R:R:M352	R:R:Y356	3.59	Yes	Yes	1	0	0
148	R:R:F386	R:R:M352	4.98	Yes	Yes	1	9	0
149	R:R:A379	R:R:Y356	5.34	No	Yes	0	7	0
150	R:R:V382	R:R:Y356	5.05	Yes	Yes	1	8	0
151	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	0
152	R:R:Y356	R:R:Y435	2.98	Yes	Yes	1	0	9
153	R:R:F358	R:R:R362	9.62	No	No	0	0	0
154	R:R:F376	R:R:V360	6.55	No	No	0	4	0
155	R:R:K374	R:R:V378	3.04	No	No	0	9	8
156	R:R:F376	R:R:V380	7.87	No	No	0	4	3
157	R:R:L438	R:R:V378	4.47	No	No	0	7	8
158	R:R:L434	R:R:V381	2.98	No	No	0	9	7
159	R:R:L434	R:R:V382	2.98	No	Yes	0	9	8
160	R:R:V382	R:R:Y435	5.05	Yes	Yes	1	8	9
161	R:R:L387	R:R:V383	2.98	No	No	0	6	8
162	R:R:F430	R:R:V385	3.93	No	No	0	7	7
163	R:R:L434	R:R:V385	4.47	No	No	0	9	7
164	R:R:F386	R:R:W390	15.03	Yes	Yes	1	9	9
165	R:R:L387	R:R:T391	2.95	No	Yes	0	6	6
166	R:R:C389	R:R:W390	3.92	No	Yes	1	9	9
167	R:R:C389	R:R:N427	9.45	No	No	1	9	9
168	R:R:N427	R:R:W390	13.56	No	Yes	1	9	9
169	R:R:P392	R:R:T391	5.25	No	Yes	0	9	6
170	R:R:I395	R:R:T391	3.04	No	Yes	0	5	6
171	R:R:H394	R:R:Y393	5.44	No	Yes	2	9	9
172	R:R:I421	R:R:Y393	3.63	No	Yes	2	4	9
173	L:L:?1	R:R:Y393	22.57	Yes	Yes	2	0	9
174	R:R:F396	R:R:L413	6.09	No	No	0	4	7
175	R:R:F396	R:R:W416	3.01	No	Yes	0	4	7
176	R:R:C420	R:R:F396	9.78	No	No	0	6	4
177	L:L:?1	R:R:G397	5.88	Yes	No	0	0	8
178	R:R:L413	R:R:T403	4.42	No	No	0	7	2
179	R:R:D404	R:R:T407	2.89	No	Yes	0	4	7
180	R:R:S415	R:R:T412	3.2	No	No	0	5	6
181	R:R:S415	R:R:W416	3.71	No	Yes	0	5	7
182	R:R:V419	R:R:W416	7.36	No	Yes	0	5	7
183	R:R:D417	R:R:I421	4.2	No	No	2	8	4
184	L:L:?1	R:R:D417	14	Yes	No	2	0	8
185	L:L:?1	R:R:H418	4.42	Yes	No	0	0	4
186	L:L:?1	R:R:I421	16.68	Yes	No	2	0	4
187	R:R:A426	R:R:F430	4.16	No	No	0	8	7
188	R:R:N427	R:R:N431	9.54	No	Yes	1	9	9
189	R:R:F433	R:R:P432	2.89	No	No	0	6	9
190	R:R:F433	R:R:L437	3.65	No	No	0	6	7
191	R:R:K444	R:R:K445	5.75	No	No	0	5	7
192	R:R:K444	R:R:Q448	9.49	No	No	0	5	7
193	R:R:K445	R:R:M52	2.88	No	Yes	0	7	9
194	R:R:K374	R:R:K440	2.87	No	No	0	9	7
195	R:R:I450	R:R:L43	2.85	No	No	0	4	8
196	R:R:I395	R:R:L399	2.85	No	No	0	5	9
197	R:R:L79	R:R:M27	2.83	No	No	0	6	6
198	R:R:L82	R:R:M27	2.83	No	No	0	7	6
199	R:R:I128	R:R:N132	2.83	No	No	0	7	8
200	R:R:C121	R:R:F358	2.79	No	No	0	9	0
201	R:R:P156	R:R:Y160	2.78	No	Yes	0	9	8
202	R:R:A436	R:R:F61	2.77	No	No	0	8	8
203	R:R:L333	R:R:L401	2.77	No	No	0	0	7
204	R:R:A436	R:R:F442	2.77	No	Yes	0	8	9
205	R:R:H63	R:R:I59	2.65	No	No	0	8	6
206	R:R:C130	R:R:W129	2.61	No	No	0	7	6
207	R:R:A424	R:R:W390	2.59	No	Yes	0	9	9
208	R:R:F158	R:R:K96	2.48	No	No	0	8	8
209	R:R:F125	R:R:K126	2.48	No	No	0	6	6
210	R:R:M138	R:R:R134	2.48	No	Yes	0	6	9
211	R:R:S109	R:R:W390	2.47	No	Yes	0	9	9
212	R:R:V56	R:R:W60	2.45	No	Yes	0	8	8
213	R:R:L438	R:R:R443	2.43	No	No	0	7	9
214	R:R:G40	R:R:P39	2.03	No	No	0	9	7
215	R:R:Y160	R:R:Y174	1.99	Yes	No	0	8	7
216	R:R:C140	R:R:G137	1.96	No	No	0	4	5
217	R:R:G344	R:R:V343	1.84	No	No	0	0	0
218	R:R:G410	R:R:T403	1.82	No	No	0	3	2
219	R:R:G410	R:R:T407	1.82	No	Yes	0	3	7
220	R:R:A108	R:R:A150	1.79	No	No	0	9	9
221	R:R:P408	R:R:T407	1.75	No	Yes	0	4	7
222	R:R:C145	R:R:V149	1.71	No	No	0	6	4
223	R:R:G37	R:R:N41	1.7	No	No	0	9	9
224	R:R:A139	R:R:V56	1.7	No	No	0	7	8
225	R:R:C429	R:R:T33	1.69	No	No	0	9	8
226	R:R:D441	R:R:G439	1.68	No	No	0	7	9
227	R:R:L84	R:R:P89	1.64	No	No	0	8	8
228	R:R:C172	R:R:I163	1.64	Yes	No	0	8	6
229	R:R:L347	R:R:P348	1.64	No	Yes	0	0	0
230	R:R:L423	R:R:P392	1.64	No	No	0	8	9
231	R:R:S31	R:R:V28	1.62	No	No	0	7	6
232	R:R:S349	R:R:V350	1.62	No	No	0	0	0
233	R:R:D404	R:R:P405	1.61	No	No	0	4	4
234	R:R:V148	R:R:V152	1.6	No	No	0	5	5
235	R:R:V342	R:R:V343	1.6	No	No	0	0	0
236	R:R:V378	R:R:V382	1.6	No	Yes	0	8	8
237	R:R:C429	R:R:L36	1.59	No	No	0	9	8
238	R:R:C130	R:R:L122	1.59	No	No	0	7	7
239	R:R:T339	R:R:V343	1.59	No	No	0	0	0
240	R:R:A67	R:R:L112	1.58	No	No	0	9	9
241	R:R:I353	R:R:S357	1.55	No	No	0	0	0
242	R:R:I24	R:R:V28	1.54	No	No	0	7	6
243	R:R:I59	R:R:V136	1.54	No	No	0	6	7
244	R:R:I338	R:R:V334	1.54	No	No	0	0	0
245	R:R:I338	R:R:V342	1.54	No	No	0	0	0
246	R:R:M153	R:R:V152	1.52	No	No	0	8	5
247	R:R:F442	R:R:G439	1.51	Yes	No	0	9	9
248	R:R:L341	R:R:V398	1.49	No	No	0	0	7
249	R:R:L423	R:R:V388	1.49	No	No	0	8	6
250	R:R:L409	R:R:T403	1.47	No	No	0	3	2
251	R:R:L409	R:R:T407	1.47	No	Yes	0	3	7
252	R:R:I24	R:R:M27	1.46	No	No	0	7	6
253	R:R:G91	R:R:Y90	1.45	No	No	0	9	7
254	R:R:M138	R:R:N135	1.4	No	No	0	6	5
255	R:R:L35	R:R:L36	1.38	No	No	0	6	8
256	R:R:L38	R:R:L69	1.38	Yes	No	4	7	7
257	R:R:L38	R:R:L73	1.38	Yes	No	4	7	8
258	R:R:E162	R:R:K175	1.35	No	No	0	5	5
259	R:R:L84	R:R:Q87	1.33	No	No	0	8	6
260	R:R:F386	R:R:S349	1.32	Yes	No	0	9	0
261	R:R:R377	R:R:V381	1.31	No	No	0	5	7
262	R:R:F93	R:R:L94	1.22	No	No	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L38	4.265	4	4	7
2	R:R:M52	4.0475	4	0	9
3	R:R:W60	4.4	5	0	8
4	R:R:L64	6.0175	4	1	9
5	R:R:D68	8.5875	4	1	9
6	R:R:W88	7.5775	4	0	9
7	R:R:T114	4.8125	4	1	8
8	R:R:R134	8.482	5	5	9
9	R:R:Y160	3.35	4	0	8
10	R:R:R161	8.092	5	2	8
11	R:R:C172	4.44	4	2	8
12	R:R:F345	8.8425	4	2	0
13	R:R:P348	4.055	4	0	0
14	R:R:M352	5.565	4	1	0
15	R:R:Y356	4.095	6	1	0
16	R:R:V382	3.67	4	1	8
17	R:R:F386	6.315	4	1	9
18	R:R:W390	7.59	7	1	9
19	R:R:T391	4.4325	4	0	6
20	R:R:Y393	8.94	4	2	9
21	R:R:T407	1.9825	4	0	7
22	R:R:W416	4.5325	4	0	7
23	R:R:N431	8.855	4	1	9
24	R:R:Y435	6.29333	6	1	9
25	R:R:F442	4.196	5	0	9
26	L:L:?1	9.71615	13	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E20	R:R:V23	30.8403	5.7	No	No	0	4	4
2	R:R:L82	R:R:V23	32.2772	4.47	No	No	0	7	4
3	R:R:E20	R:R:P22	27.8243	9.43	No	No	3	4	4
4	R:R:P22	R:R:W416	26.4839	4.05	No	Yes	0	4	7
5	R:R:L30	R:R:S78	10.3478	3	No	No	0	6	8
6	R:R:C72	R:R:S428	11.0536	3.44	No	No	0	8	9
7	R:R:D68	R:R:S428	19.0861	7.36	Yes	No	0	9	9
8	R:R:D68	R:R:N431	31.4598	10.77	Yes	Yes	1	9	9
9	R:R:N427	R:R:N431	70.8708	9.54	No	Yes	1	9	9
10	R:R:N427	R:R:W390	69.8299	13.56	No	Yes	1	9	9
11	R:R:M106	R:R:W390	100	6.98	No	Yes	0	9	9
12	R:R:I102	R:R:M106	98.8525	4.37	No	No	0	8	9
13	L:L:?1	R:R:I102	96.9789	3.93	Yes	No	0	0	8
14	L:L:?1	R:R:H418	42.6047	4.42	Yes	No	0	0	4
15	R:R:H418	R:R:L82	41.5588	3.86	No	No	0	4	7
16	R:R:D68	R:R:N41	36.8266	8.08	Yes	No	0	9	9
17	R:R:N41	R:R:P432	31.0688	13.03	No	No	0	9	9
18	R:R:F433	R:R:P432	30.0736	2.89	No	No	0	6	9
19	R:R:F433	R:R:L437	29.0683	3.65	No	No	0	6	7
20	R:R:L437	R:R:V44	28.0427	2.98	No	No	0	7	9
21	R:R:F442	R:R:V44	24.8997	6.55	Yes	No	0	9	9
22	R:R:F442	R:R:M52	12.0284	6.22	Yes	Yes	0	9	9
23	R:R:F386	R:R:W390	29.312	15.03	Yes	Yes	1	9	9
24	R:R:F386	R:R:M352	28.3321	4.98	Yes	Yes	1	9	0
25	R:R:M352	R:R:Y356	31.9066	3.59	Yes	Yes	1	0	0
26	R:R:Y356	R:R:Y435	36.8825	2.98	Yes	Yes	1	0	9
27	R:R:I116	R:R:Y435	79.1318	3.63	No	Yes	1	9	9
28	R:R:I116	R:R:W60	77.5984	8.22	No	Yes	0	9	8
29	R:R:C143	R:R:W60	17.0957	3.92	No	Yes	0	8	8
30	R:R:C143	R:R:H63	15.2577	14.74	No	No	0	8	8
31	R:R:L64	R:R:N431	20.0152	6.87	Yes	Yes	1	9	9
32	R:R:L64	R:R:Y435	39.0201	3.52	Yes	Yes	1	9	9
33	R:R:L113	R:R:N431	20.2742	8.24	No	Yes	1	8	9
34	R:R:L113	R:R:Y435	19.8578	16.41	No	Yes	1	8	9
35	R:R:V56	R:R:W60	57.5273	2.45	No	Yes	0	8	8
36	R:R:R134	R:R:V56	53.8309	15.69	Yes	No	0	9	8
37	L:L:?1	R:R:H81	15.5369	20.33	Yes	No	0	0	7
38	R:R:H81	R:R:W88	12.7697	9.52	No	Yes	0	7	9
39	L:L:?1	R:R:I98	15.0952	5.89	Yes	No	0	0	8
40	R:R:I98	R:R:W88	12.5006	3.52	No	Yes	0	8	9
41	R:R:W88	R:R:Y90	16.065	11.58	Yes	No	0	9	7
42	L:L:?1	R:R:V103	11.1399	3.07	Yes	No	0	0	5
43	R:R:F107	R:R:R340	12.1503	7.48	No	No	0	8	0
44	R:R:R340	R:R:Y393	13.1962	4.12	No	Yes	0	0	9
45	L:L:?1	R:R:Y393	16.1665	22.57	Yes	Yes	2	0	9
46	R:R:V110	R:R:W390	10.8555	8.58	No	Yes	1	9	9
47	R:R:P348	R:R:V110	10.2615	3.53	Yes	No	0	0	9
48	R:R:R134	R:R:V123	38.426	3.92	Yes	No	5	9	5
49	R:R:C130	R:R:V123	36.786	5.12	No	No	0	7	5
50	R:R:F125	R:R:F358	13.1556	7.5	No	No	0	6	0
51	R:R:F125	R:R:K126	15.3592	2.48	No	No	0	6	6
52	R:R:I128	R:R:K126	17.5476	5.82	No	No	0	7	6
53	R:R:I128	R:R:N132	21.8939	2.83	No	No	0	7	8
54	R:R:H133	R:R:N132	26.1995	3.83	No	No	0	8	8
55	R:R:H133	R:R:W129	28.3371	23.27	No	No	0	8	6
56	R:R:C130	R:R:W129	30.4646	2.61	No	No	0	7	6
57	R:R:M138	R:R:R134	10.8251	2.48	No	Yes	0	6	9
58	L:L:?1	R:R:Y174	10.7743	8.87	Yes	No	2	0	7
59	R:R:G344	R:R:P348	13.9629	4.06	No	Yes	0	0	0
60	R:R:G344	R:R:V343	12.4194	1.84	No	No	0	0	0
61	R:R:H394	R:R:Y393	10.9317	5.44	No	Yes	2	9	9
62	R:R:F345	R:R:T391	11.3734	6.49	Yes	Yes	0	0	6
63	R:R:L387	R:R:T391	12.7748	2.95	No	Yes	0	6	6
64	R:R:L387	R:R:V383	12.9931	2.98	No	No	0	6	8
65	R:R:F396	R:R:W416	22.3509	3.01	No	Yes	0	4	7
66	R:R:F396	R:R:L413	19.604	6.09	No	No	0	4	7
67	R:R:L413	R:R:T403	18.035	4.42	No	No	0	7	2
68	L:L:?1	R:R:S78	11.4039	12.39	Yes	No	0	0	8
69	R:R:D68	R:R:L64	19.6903	8.14	Yes	Yes	1	9	9
70	R:R:V383	R:R:Y356	13.115	3.79	No	Yes	0	8	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L30	R:R:S78	3	0	No	No	6	8	2	1
R:R:I102	R:R:S74	6.19	0	No	No	8	9	1	2
L:L:?1	R:R:S78	12.39	2	Yes	No	0	8	0	1
R:R:G86	R:R:H81	3.18	0	No	No	7	7	2	1
R:R:H81	R:R:W88	9.52	0	No	Yes	7	9	1	2
L:L:?1	R:R:H81	20.33	2	Yes	No	0	7	0	1
R:R:H418	R:R:L82	3.86	0	No	No	4	7	1	2
R:R:I98	R:R:W88	3.52	0	No	Yes	8	9	1	2
R:R:C172	R:R:C95	7.28	2	Yes	No	8	9	1	2
R:R:I98	R:R:P99	3.39	0	No	No	8	8	1	2
L:L:?1	R:R:I98	5.89	2	Yes	No	0	8	0	1
R:R:P99	R:R:R161	11.53	0	No	Yes	8	8	2	1
R:R:I102	R:R:M106	4.37	0	No	No	8	9	1	2
L:L:?1	R:R:I102	3.93	2	Yes	No	0	8	0	1
R:R:V103	R:R:V157	6.41	0	No	No	5	9	1	2
L:L:?1	R:R:V103	3.07	2	Yes	No	0	5	0	1
R:R:C172	R:R:R161	5.57	2	Yes	Yes	8	8	1	1
R:R:G173	R:R:R161	6	0	No	Yes	1	8	2	1
R:R:R161	R:R:Y174	12.35	2	Yes	No	8	7	1	1
L:L:?1	R:R:R161	5.01	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:C172	3.27	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y174	8.87	2	Yes	No	0	7	0	1
R:R:R340	R:R:Y393	4.12	0	No	Yes	0	9	2	1
R:R:H394	R:R:Y393	5.44	2	No	Yes	9	9	2	1
R:R:I421	R:R:Y393	3.63	2	No	Yes	4	9	1	1
L:L:?1	R:R:Y393	22.57	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:G397	5.88	2	Yes	No	0	8	0	1
R:R:D417	R:R:I421	4.2	2	No	No	8	4	1	1
L:L:?1	R:R:D417	14	2	Yes	No	0	8	0	1
L:L:?1	R:R:H418	4.42	2	Yes	No	0	4	0	1
L:L:?1	R:R:I421	16.68	2	Yes	No	0	4	0	1
R:R:Y160	R:R:Y174	1.99	0	Yes	No	8	7	2	1
R:R:C172	R:R:I163	1.64	2	Yes	No	8	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZWF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	241
Number of Links	262
Number of Hubs	26
Number of Links mediated by Hubs	106
Number of Communities	5
Number of Nodes involved in Communities	36
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	38059
Length Of Smallest Path	3
Average Path Length	14.5509
Length of Longest Path	36
Minimum Path Strength	1.47
Average Path Strength	6.14419
Maximum Path Strength	17.4733
Minimum Path Correlation	0.7
Average Path Correlation	0.916477
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	38.3669
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.0827
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>8ZWF_nogp_Chain_R N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I N R C G Y K S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KVP	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-	Go/β1/γ2	2.79	2025-11-26	10.1101/2025.05.26.656101
	9KVP (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-		2.79	2025-11-26	10.1101/2025.05.26.656101
	9KZ2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-	Go/β1/γ2	3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-		3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-	Go/β1/γ2	3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZ8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-		3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZK	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-	Go/β1/γ2	3.54	2025-11-26	10.1101/2025.05.26.656101
	9KZK (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-		3.54	2025-11-26	10.1101/2025.05.26.656101
	9L0H	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-	Go/β1/γ2	3.57	2025-11-26	10.1101/2025.05.26.656101
	9L0H (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-		3.57	2025-11-26	10.1101/2025.05.26.656101
	9UMJ	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-	Go/β1/γ2	3.38	2025-11-26	10.1101/2025.05.26.656101
	9UMJ (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-		3.38	2025-11-26	10.1101/2025.05.26.656101
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWF (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9KUT	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Go/β1/γ2	3.29	2025-11-26	10.1101/2025.05.26.656101
	9KUT (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3.29	2025-11-26	10.1101/2025.05.26.656101
	9KV6	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV6 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	3.17	2025-11-26	10.1101/2025.05.26.656101
	9KV8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		3.17	2025-11-26	10.1101/2025.05.26.656101

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8ZWF_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.