Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:R21 8.8725400
2R:R:Q20 8.19404
3R:R:T33 4.0275409
4R:R:C34 3.926506
5R:R:N41 5.416509
6R:R:V56 4.665429
7R:R:W60 6.404508
8R:R:H63 8.095418
9R:R:L64 4.786519
10R:R:D68 7.212519
11R:R:L75 4.865408
12R:R:H87 9.6575406
13R:R:W88 10.894549
14R:R:Y90 12.22408
15R:R:F107 6.645408
16R:R:L112 3.6025419
17R:R:C121 4.905488
18R:R:R134 8.232529
19R:R:W147 5.012519
20R:R:D162 8.1625476
21R:R:F176 6.8475405
22R:R:V336 3.01404
23R:R:F338 6.965409
24R:R:F342 5.985403
25R:R:Y349 6.668518
26R:R:F379 7.72509
27R:R:W383 8.635409
28R:R:Y386 7.158508
29R:R:M407 5.0925401
30R:R:N424 9.5275419
31R:R:Y428 6.185619
32R:R:L430 2.83407
33R:R:F435 4.234569
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:H14 R:R:M407 10.16679.19NoYes001
2L:L:Y13 R:R:M407 44.56133.59NoYes001
3L:L:Y13 R:R:H411 42.117619.6NoNo004
4R:R:H411 R:R:S26 25.20242.79NoNo048
5R:R:M412 R:R:S26 22.71483.07NoNo068
6R:R:M412 R:R:W409 17.71759.31NoNo065
7R:R:S408 R:R:W409 15.20794.94NoNo065
8R:R:Q22 R:R:S408 12.69110.11NoNo046
9R:R:Q20 R:R:Q22 10.16673.84YesNo044
10L:L:Y13 R:R:D410 86.48114.94NoNo009
11R:R:F176 R:R:L326 13.48963.65YesNo053
12R:R:L326 R:R:L394 14.78664.15NoNo937
13R:R:L394 R:R:T330 20.17225.9NoNo078
14R:R:T330 R:R:V391 21.47651.59NoNo087
15R:R:L334 R:R:V391 22.71842.98NoNo077
16R:R:L334 R:R:L339 24.00072.77NoNo078
17R:R:F338 R:R:L339 25.27574.87YesNo098
18R:R:F338 R:R:H387 32.921812.44YesNo099
19R:R:H387 R:R:Y386 73.8674.36NoYes098
20L:L:R21 R:R:Y386 10016.46YesYes008
21L:L:R21 R:R:D410 98.527211.91YesNo009
22L:L:L17 L:L:P18 17.94474.93NoNo000
23L:L:P18 R:R:D410 19.9456.44NoNo009
24L:L:L17 R:R:R161 15.93337.29NoNo008
25L:L:P19 R:R:S78 53.91837.13NoNo008
26L:L:S20 R:R:S78 56.02123.26NoNo008
27L:L:S20 R:R:I414 62.30817.74NoNo005
28R:R:I414 R:R:Y386 64.41846.04NoYes058
29L:L:R21 R:R:R333 24.03743.2YesNo009
30R:R:H411 R:R:L82 14.922114.14NoNo047
31R:R:L82 R:R:M27 12.6911.41NoNo076
32R:R:I24 R:R:M27 10.16674.37NoNo076
33R:R:M106 R:R:Y386 86.0673.59NoYes098
34R:R:C71 R:R:M106 39.99274.86NoNo089
35R:R:C71 R:R:S421 38.49796.89NoNo089
36R:R:D68 R:R:S421 38.22685.89YesNo099
37R:R:D68 R:R:N41 50.13376.73YesYes099
38R:R:F69 R:R:N41 22.07734.83NoYes079
39R:R:F69 R:R:L38 20.0442.44NoNo577
40R:R:C34 R:R:L38 19.12073.17YesNo067
41R:R:C34 R:R:L75 14.04656.35YesYes068
42R:R:N41 R:R:T65 28.6065.85YesNo099
43R:R:T65 R:R:V44 26.73757.93NoNo099
44R:R:F435 R:R:V44 24.75547.87YesNo699
45R:R:F435 R:R:V47 12.81553.93YesNo098
46R:R:F107 R:R:R333 19.35899.62YesNo089
47R:R:F107 R:R:V110 18.84235.24YesNo089
48R:R:F379 R:R:V110 23.37423.93YesNo099
49R:R:F379 R:R:M345 72.28.71YesNo097
50R:R:M345 R:R:Y349 44.17294.79NoYes178
51R:R:R120 R:R:Y349 50.69799.26NoYes198
52R:R:I116 R:R:R120 39.73997.52NoNo199
53R:R:I116 R:R:W60 88.21035.87NoYes098
54R:R:D119 R:R:W60 76.761311.17NoYes098
55R:R:D119 R:R:R134 44.777414.29NoYes299
56R:R:R134 R:R:V56 13.04277.85YesYes299
57R:R:M106 R:R:W383 50.16674.65NoYes099
58R:R:F379 R:R:W383 49.239812.03YesYes099
59R:R:H387 R:R:W383 55.34713.17NoYes099
60R:R:F338 R:R:F379 33.21495.36YesYes099
61R:R:D68 R:R:L64 34.06485.43YesYes199
62R:R:L64 R:R:Y428 52.94384.69YesYes199
63R:R:I116 R:R:Y428 51.38676.04NoYes199
64R:R:N420 R:R:W383 79.17214.69NoYes099
65R:R:N420 R:R:N424 77.589312.26NoYes099
66R:R:L64 R:R:N424 37.34384.12YesYes199
67R:R:L113 R:R:N424 25.97559.61NoYes199
68R:R:L113 R:R:Y428 24.96437.03NoYes199
69R:R:L112 R:R:L64 20.00734.15YesYes199
70R:R:W88 R:R:Y90 22.47325.08YesYes098
71R:R:P89 R:R:Y90 17.14235.56NoYes088
72R:R:H87 R:R:P89 14.73913.73YesNo068
73R:R:C95 R:R:W88 18.24517.84NoYes499
74R:R:C95 R:R:L163 16.05423.17NoNo096
75R:R:D162 R:R:L163 11.61021.36YesNo066
76R:R:I103 R:R:R333 16.043212.53NoNo059
77R:R:M345 R:R:S117 27.14057.67NoNo179
78R:R:C348 R:R:S117 34.76095.16NoNo089
79R:R:D119 R:R:I123 29.04565.6NoNo295
80R:R:C121 R:R:C348 24.51737.28YesNo088
81R:R:C121 R:R:I352 12.43823.27YesNo089
82R:R:C130 R:R:I123 25.84723.27NoNo285
83R:R:C130 R:R:L122 45.38934.76NoNo087
84R:R:K126 R:R:L122 19.49444.23NoNo067
85R:R:C130 R:R:R134 25.99384.18NoYes289
86R:R:L122 R:R:W129 19.49443.42NoNo078
87R:R:K126 R:R:P127 13.00241.67NoNo069
88R:R:H133 R:R:W129 13.002420.1NoNo088
89R:R:V375 R:R:Y428 21.513110.09NoYes099
90R:R:V371 R:R:V375 19.5861.6NoNo089
91R:R:K367 R:R:V371 13.29553.04NoNo098
92R:R:K367 R:R:N366 11.09731.4NoNo095
93R:R:L393 R:R:M407 19.93774.24NoYes011
94R:R:L393 R:R:V406 17.71394.47NoNo017
95R:R:M407 R:R:P398 12.6913.35YesNo013
96R:R:D397 R:R:P398 10.16676.44NoNo043
97R:R:D68 R:R:N424 14.383612.12YesYes199
98L:L:P19 R:R:W88 45.65674.05NoYes009
99R:R:R120 R:R:Y428 10.19236.17NoYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R9 R:R:Q20 16.35 0 No Yes 0 4 0 1
L:L:R10 R:R:E404 5.82 0 No No 0 3 0 1
L:L:Y13 R:R:M407 3.59 0 No Yes 0 1 0 1
L:L:Y13 R:R:D410 14.94 0 No No 0 9 0 1
L:L:Y13 R:R:H411 19.6 0 No No 0 4 0 1
L:L:H14 R:R:M407 9.19 0 No Yes 0 1 0 1
L:L:H15 R:R:I165 3.98 3 No No 0 4 0 1
L:L:H15 R:R:M166 3.94 3 No No 0 2 0 1
L:L:H15 R:R:I171 5.3 3 No No 0 1 0 1
L:L:L17 R:R:R161 7.29 0 No No 0 8 0 1
L:L:P18 R:R:D410 6.44 0 No No 0 9 0 1
L:L:P19 R:R:S78 7.13 0 No No 0 8 0 1
L:L:P19 R:R:H81 12.2 0 No No 0 8 0 1
L:L:P19 R:R:W88 4.05 0 No Yes 0 9 0 1
L:L:S20 R:R:S78 3.26 0 No No 0 8 0 1
L:L:S20 R:R:I414 7.74 0 No No 0 5 0 1
L:L:R21 R:R:R333 3.2 0 Yes No 0 9 0 1
L:L:R21 R:R:Y386 16.46 0 Yes Yes 0 8 0 1
L:L:R21 R:R:V389 3.92 0 Yes No 0 4 0 1
L:L:R21 R:R:D410 11.91 0 Yes No 0 9 0 1
R:R:P21 R:R:Q20 4.74 0 No Yes 5 4 2 1
R:R:Q20 R:R:Q22 3.84 0 Yes No 4 4 1 2
R:R:D23 R:R:Q20 7.83 0 No Yes 4 4 2 1
R:R:I102 R:R:S74 9.29 0 No No 8 9 1 2
R:R:G86 R:R:H81 6.35 0 No No 8 8 2 1
R:R:H411 R:R:L82 14.14 0 No No 4 7 1 2
R:R:W88 R:R:Y90 25.08 4 Yes Yes 9 8 1 2
R:R:C95 R:R:W88 7.84 4 No Yes 9 9 2 1
R:R:I98 R:R:W88 7.05 0 No Yes 8 9 2 1
R:R:C172 R:R:W88 10.45 4 No Yes 9 9 2 1
R:R:C172 R:R:C95 5.46 4 No No 9 9 2 2
R:R:I98 R:R:P99 3.39 0 No No 8 8 2 2
R:R:P99 R:R:R161 21.62 0 No No 8 8 2 1
R:R:I103 R:R:R333 12.53 0 No No 5 9 2 1
R:R:M106 R:R:Y386 3.59 0 No Yes 9 8 2 1
R:R:F107 R:R:R333 9.62 0 Yes No 8 9 2 1
R:R:R161 R:R:Y174 18.52 0 No No 8 8 1 2
R:R:I165 R:R:R173 6.26 0 No No 4 1 1 2
R:R:D167 R:R:M166 4.16 0 No No 3 2 2 1
R:R:I171 R:R:M166 8.75 3 No No 1 2 1 1
R:R:H387 R:R:Y386 4.36 0 No Yes 9 8 2 1
R:R:I414 R:R:Y386 6.04 0 No Yes 5 8 1 1
R:R:A417 R:R:Y386 5.34 0 No Yes 9 8 2 1
R:R:S413 R:R:V389 9.7 0 No No 6 4 2 1
R:R:L393 R:R:M407 4.24 0 No Yes 1 1 2 1
R:R:M407 R:R:P398 3.35 0 Yes No 1 3 1 2
L:L:S20 R:R:I102 3.1 0 No No 0 8 0 1
L:L:A16 R:R:H81 2.93 0 No No 0 8 0 1
R:R:H411 R:R:S26 2.79 0 No No 4 8 1 2
R:R:G390 R:R:V389 1.84 0 No No 8 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9KV8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.17
Number of Linked Nodes 282
Number of Links 306
Number of Hubs 33
Number of Links mediated by Hubs 128
Number of Communities 9
Number of Nodes involved in Communities 40
Number of Links involved in Communities 47
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 73612
Length Of Smallest Path 3
Average Path Length 15.2629
Length of Longest Path 29
Minimum Path Strength 1.305
Average Path Strength 7.09579
Maximum Path Strength 20.07
Minimum Path Correlation 0.7
Average Path Correlation 0.928583
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 43.5908
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.4725
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO09047
Sequence
>9KV8_nogp_Chain_R
PLFQPQDIA SMVILGLTC LLGLLGNGL VLWVAGVKM KTTVNTVWF 
LHLTLADFL CCLSLPFSL AHLILQGHW PYGLFLCKL IPSIIILNM 
FASVFLLTA ISLDRCLIV HKPIWCQNH RNVRTAFAI CGCVWVVAF 
VMCVPVFVY RDLFIMDNR SICRYNFDV PTPLMAITI TRLVVGFLV 
PFFIMVICY SLIVFRMRK TNFTKSRNK TFRVAVAVV TVFFICWTP 
YHLVGVLLL ITDPESSLG EAVMSWDHM SIALASANS CFNPFLYAL 
LGKDFRKKA RQSI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
9KVPAPeptideComplement PeptideC3aBHomo sapiensSB290157-Go/β1/γ22.792025-11-2610.1101/2025.05.26.656101
9KVP (No Gprot) APeptideComplement PeptideC3aBHomo sapiensSB290157-2.792025-11-2610.1101/2025.05.26.656101
9KZ2APeptideComplement PeptideC3aBHomo sapiensEP67-Go/β1/γ23.432025-11-2610.1101/2025.05.26.656101
9KZ2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP67-3.432025-11-2610.1101/2025.05.26.656101
9KZ8APeptideComplement PeptideC3aBMus musculusEP67-Go/β1/γ23.32025-11-2610.1101/2025.05.26.656101
9KZ8 (No Gprot) APeptideComplement PeptideC3aBMus musculusEP67-3.32025-11-2610.1101/2025.05.26.656101
9KZKAPeptideComplement PeptideC3aBMus musculusC3a (fragment)-Go/β1/γ23.542025-11-2610.1101/2025.05.26.656101
9KZK (No Gprot) APeptideComplement PeptideC3aBMus musculusC3a (fragment)-3.542025-11-2610.1101/2025.05.26.656101
9L0HAPeptideComplement PeptideC3aBMus musculusJR14a-Go/β1/γ23.572025-11-2610.1101/2025.05.26.656101
9L0H (No Gprot) APeptideComplement PeptideC3aBMus musculusJR14a-3.572025-11-2610.1101/2025.05.26.656101
9UMJAPeptideComplement PeptideC3aBMus musculusEP54-Go/β1/γ23.382025-11-2610.1101/2025.05.26.656101
9UMJ (No Gprot) APeptideComplement PeptideC3aBMus musculusEP54-3.382025-11-2610.1101/2025.05.26.656101
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWF (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9KUTAPeptideComplement PeptideC3aBHomo sapiensJR14a-Go/β1/γ23.292025-11-2610.1101/2025.05.26.656101
9KUT (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-3.292025-11-2610.1101/2025.05.26.656101
9KV6APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ22.882025-11-2610.1101/2025.05.26.656101
9KV6 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-2.882025-11-2610.1101/2025.05.26.656101
9KV8APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ23.172025-11-2610.1101/2025.05.26.656101
9KV8 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-3.172025-11-2610.1101/2025.05.26.656101




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Download 9KV8_nogp.zip



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