Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:R739 1.6875404
2L:L:L746 6.7875427
3L:L:R748 5.812518
4R:R:L30 3.72466
5R:R:L38 4.08407
6R:R:N41 6.9375409
7R:R:L43 1.5525409
8R:R:W60 5.48833608
9R:R:L64 4.584539
10R:R:D68 7.85539
11R:R:W88 7.55167629
12R:R:Y90 9.0025428
13R:R:L92 5.1675402
14R:R:C95 7.7775429
15R:R:M106 3.675419
16R:R:F107 4.855478
17R:R:I116 5.3175439
18R:R:R134 6.698549
19R:R:W147 4.802509
20R:R:R161 11.39628
21R:R:G337 3.8175479
22R:R:P341 4.0925409
23R:R:F342 5.925403
24R:R:C382 4.29409
25R:R:W383 6.14833619
26R:R:Y386 7.49518
27R:R:V389 3.61414
28R:R:T396 3.7025413
29R:R:V406 3.668517
30R:R:D410 4.8975419
31R:R:I414 3.89415
32R:R:N424 8.6439
33R:R:Y428 6.818539
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:R739 R:R:D23 17.42621.19YesNo044
2L:L:L746 R:R:R161 13.10688.5YesYes278
3R:R:R161 R:R:Y174 48.4815.14YesNo088
4L:L:R748 R:R:Y174 53.95033.09YesNo088
5L:L:R748 R:R:Y386 1008.23YesYes188
6R:R:W383 R:R:Y386 79.23039.65YesYes198
7R:R:N420 R:R:W383 95.24356.78NoYes099
8R:R:C382 R:R:N420 54.658911.02YesNo099
9R:R:C382 R:R:F423 49.35082.79YesNo096
10R:R:A419 R:R:F423 47.98464.16NoNo086
11R:R:A419 R:R:T33 46.60983.36NoNo089
12R:R:L75 R:R:T33 42.43472.95NoNo089
13R:R:L30 R:R:L75 39.49854.15YesNo668
14R:R:L30 R:R:S26 36.7493YesNo068
15R:R:M412 R:R:S26 35.30633.07NoNo068
16R:R:M412 R:R:W409 32.39564.65NoNo065
17R:R:S408 R:R:W409 30.92753.71NoNo065
18R:R:Q22 R:R:S408 27.96594.33NoNo046
19R:R:Q20 R:R:Q22 24.902414.08NoNo544
20R:R:D23 R:R:Q20 23.45985.22NoNo044
21L:L:A747 R:R:M106 16.56913.22NoYes079
22L:L:A747 R:R:I414 16.18723.25NoYes075
23L:L:R748 R:R:R333 31.81433.2YesNo089
24L:L:R748 R:R:D410 38.83239.53YesYes189
25R:R:N420 R:R:N424 96.13035.45NoYes099
26R:R:D68 R:R:N424 52.376112.12YesYes399
27R:R:D68 R:R:N41 59.81424.04YesYes099
28R:R:F69 R:R:N41 27.69434.83NoYes079
29R:R:F69 R:R:L38 26.02682.44NoYes077
30R:R:C34 R:R:L38 14.11663.17NoYes067
31R:R:C34 R:R:G31 10.63731.96NoNo066
32R:R:N41 R:R:T65 34.15225.85YesNo099
33R:R:T65 R:R:V44 25.52616.35NoNo099
34R:R:F435 R:R:V44 23.86295.24NoNo099
35R:R:F435 R:R:V47 20.65096.55NoNo098
36R:R:V47 R:R:W46 10.54822.45NoNo088
37R:R:D68 R:R:L64 52.77925.43YesYes399
38R:R:I116 R:R:L64 54.24734.28YesYes399
39R:R:I116 R:R:W60 74.47813.52YesYes098
40R:R:V59 R:R:W60 12.02483.68NoYes078
41R:R:L113 R:R:N424 43.202612.36NoYes399
42R:R:L113 R:R:L64 21.69475.54NoYes399
43R:R:L113 R:R:Y428 21.01159.38NoYes399
44R:R:I116 R:R:Y428 17.11648.46YesYes399
45R:R:D119 R:R:W60 53.152614.52NoYes098
46R:R:D119 R:R:R134 30.095913.1NoYes499
47R:R:L112 R:R:L64 18.46574.15NoYes099
48R:R:L112 R:R:W147 13.67963.42NoYes099
49R:R:D68 R:R:S421 40.62298.83YesNo099
50R:R:C71 R:R:M106 41.41633.24NoYes089
51R:R:C95 R:R:R161 16.891512.54YesYes298
52R:R:S100 R:R:V157 10.58643.23NoNo088
53R:R:C95 R:R:L163 15.66964.76YesNo096
54R:R:L163 R:R:L92 12.55526.92NoYes062
55R:R:D162 R:R:L92 12.16484.07NoYes062
56R:R:V110 R:R:W383 24.12174.9NoYes099
57R:R:P341 R:R:V110 23.06093.53YesNo099
58R:R:G337 R:R:P341 24.05384.06YesYes099
59R:R:F107 R:R:G337 20.34544.52YesYes789
60R:R:C154 R:R:F107 23.08644.19NoYes078
61R:R:F107 R:R:R333 20.85884.28YesNo089
62R:R:I103 R:R:R333 14.10813.76NoNo059
63R:R:C154 R:R:I103 14.96526.55NoNo075
64R:R:C154 R:R:L104 31.11423.17NoNo077
65R:R:F151 R:R:L104 28.55146.09NoNo067
66R:R:P341 R:R:T114 23.48525.25YesNo098
67R:R:F379 R:R:W383 20.90557.02NoYes099
68R:R:F379 R:R:M345 15.63568.71NoNo097
69R:R:M345 R:R:T114 20.09933.01NoNo078
70R:R:I344 R:R:T114 31.75923.04NoNo068
71R:R:I116 R:R:R120 10.72645.01YesNo099
72R:R:M345 R:R:S117 11.21444.6NoNo079
73R:R:S117 R:R:Y349 10.91315.09NoNo098
74R:R:I344 R:R:L118 29.81594.28NoNo068
75R:R:C348 R:R:L118 27.86413.17NoNo088
76R:R:D119 R:R:I123 20.99884.2NoNo495
77R:R:C121 R:R:C348 25.90387.28NoNo088
78R:R:C121 R:R:H125 14.13785.9NoNo086
79R:R:C121 R:R:I352 10.093.27NoNo089
80R:R:C130 R:R:I123 18.69913.27NoNo485
81R:R:C130 R:R:R134 18.83494.18NoYes489
82R:R:C130 R:R:L122 32.87514.76NoNo087
83R:R:H125 R:R:R355 10.08156.77NoNo067
84R:R:K126 R:R:L122 28.20352.82NoNo067
85R:R:K126 R:R:W129 18.83494.64NoNo068
86R:R:H133 R:R:W129 14.137816.93NoNo088
87R:R:F151 R:R:V155 25.98016.55NoNo065
88R:R:V155 R:R:V159 18.27481.6NoNo054
89R:R:V159 R:R:Y160 15.66963.79NoNo048
90R:R:D162 R:R:F164 10.15789.55NoNo062
91R:R:P325 R:R:Y160 13.05582.78NoNo048
92R:R:D410 R:R:V389 43.28752.92YesYes194
93R:R:V389 R:R:V406 45.20541.6YesYes147
94R:R:L392 R:R:V406 16.08548.94NoYes197
95R:R:L392 R:R:T396 13.4254.42NoYes193
96R:R:L402 R:R:V406 16.08542.98NoYes137
97R:R:L402 R:R:T396 13.4255.9NoYes133
98R:R:D397 R:R:T396 16.13631.45NoYes043
99R:R:D397 R:R:P398 10.76463.22NoNo043
100R:R:M106 R:R:Y386 25.71713.59YesYes198
101R:R:C71 R:R:S421 40.8526.89NoNo089
102R:R:R120 R:R:Y349 10.3368.23NoNo098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R740 R:R:E404 15.12 0 No No 4 3 0 1
L:L:V743 R:R:H411 6.92 0 No No 3 4 0 1
L:L:L746 R:R:S78 6.01 2 Yes No 7 8 0 1
L:L:L746 R:R:H81 7.71 2 Yes No 7 8 0 1
L:L:L746 R:R:P99 4.93 2 Yes No 7 8 0 1
L:L:L746 R:R:R161 8.5 2 Yes Yes 7 8 0 1
L:L:A747 R:R:M106 3.22 0 No Yes 7 9 0 1
L:L:A747 R:R:I414 3.25 0 No Yes 7 5 0 1
L:L:R748 R:R:Y174 3.09 1 Yes No 8 8 0 1
L:L:R748 R:R:R333 3.2 1 Yes No 8 9 0 1
L:L:R748 R:R:Y386 8.23 1 Yes Yes 8 8 0 1
L:L:R748 R:R:D410 9.53 1 Yes Yes 8 9 0 1
L:L:R748 R:R:I414 5.01 1 Yes Yes 8 5 0 1
R:R:F19 R:R:Q85 7.03 0 No No 1 5 2 1
R:R:D23 R:R:Q20 5.22 0 No No 4 4 1 2
R:R:D23 R:R:H411 3.78 0 No No 4 4 1 1
R:R:C71 R:R:M106 3.24 0 No Yes 8 9 2 1
R:R:G86 R:R:H81 7.94 0 No No 8 8 2 1
R:R:H411 R:R:L82 3.86 0 No No 4 7 1 2
R:R:C95 R:R:W88 6.53 2 Yes Yes 9 9 2 2
R:R:R161 R:R:W88 8 2 Yes Yes 8 9 1 2
R:R:C172 R:R:W88 6.53 2 No Yes 9 9 2 2
R:R:C95 R:R:R161 12.54 2 Yes Yes 9 8 2 1
R:R:C172 R:R:C95 7.28 2 No Yes 9 9 2 2
R:R:I98 R:R:P99 3.39 0 No No 8 8 2 1
R:R:P99 R:R:R161 21.62 2 No Yes 8 8 1 1
R:R:I103 R:R:V157 4.61 0 No No 5 8 2 2
R:R:I103 R:R:R333 3.76 0 No No 5 9 2 1
R:R:M106 R:R:W383 4.65 1 Yes Yes 9 9 1 2
R:R:M106 R:R:Y386 3.59 1 Yes Yes 9 8 1 1
R:R:F107 R:R:R333 4.28 7 Yes No 8 9 2 1
R:R:V157 R:R:Y174 5.05 0 No No 8 8 2 1
R:R:C172 R:R:R161 12.54 2 No Yes 9 8 2 1
R:R:R161 R:R:Y174 5.14 2 Yes No 8 8 1 1
R:R:W383 R:R:Y386 9.65 1 Yes Yes 9 8 2 1
R:R:A417 R:R:W383 3.89 1 No Yes 9 9 2 2
R:R:H387 R:R:Y386 11.98 0 No Yes 9 8 2 1
R:R:A417 R:R:Y386 4 1 No Yes 9 8 2 1
R:R:D410 R:R:V389 2.92 1 Yes Yes 9 4 1 2
R:R:S413 R:R:V389 8.08 1 No Yes 6 4 2 2
R:R:D410 R:R:S413 2.94 1 Yes No 9 6 1 2
R:R:D410 R:R:I414 4.2 1 Yes Yes 9 5 1 1
R:R:I414 R:R:S413 3.1 1 Yes No 5 6 1 2
L:L:R739 R:R:D23 1.19 0 Yes No 4 4 0 1
L:L:R739 R:R:Q85 1.17 0 Yes No 4 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9KZK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.92
Number of Linked Nodes 264
Number of Links 290
Number of Hubs 33
Number of Links mediated by Hubs 125
Number of Communities 7
Number of Nodes involved in Communities 44
Number of Links involved in Communities 60
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 59446
Length Of Smallest Path 3
Average Path Length 15.1025
Length of Longest Path 32
Minimum Path Strength 1.18
Average Path Strength 5.61352
Maximum Path Strength 17.08
Minimum Path Correlation 0.7
Average Path Correlation 0.930529
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 46.7926
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.5713
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinC3a (fragment)
UniProtP01027
Sequence
>9KZK_nogp_Chain_L
QHRRDHVLG LAR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO09047
Sequence
>9KZK_nogp_Chain_R
LFQPQDIAS MVILGLTCL LGLLGNGLV LWVAGVKMK TTVNTVWFL 
HLTLADFLC CLSLPFSLA HLILQGHWP YGLFLCKLI PSIIILNMF 
ASVFLLTAI SLDRCLIVH KPIWCQNHR NVRTAFAIC GCVWVVAFV 
MCVPVFVYR DLFIMDNRS ICRYVPTPL MAITITRLV VGFLVPFFI 
MVICYSLIV FRMRKTNFT KSRNKTFRV AVAVVTVFF ICWTPYHLV 
GVLLLITDP ESSLGEAVM SWDHMSIAL ASANSCFNP FLYALLGKD 
FRKKARQSI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
9KVPAPeptideComplement PeptideC3aBHomo sapiensSB290157-Go/β1/γ22.792025-11-2610.1101/2025.05.26.656101
9KVP (No Gprot) APeptideComplement PeptideC3aBHomo sapiensSB290157-2.792025-11-2610.1101/2025.05.26.656101
9KZ2APeptideComplement PeptideC3aBHomo sapiensEP67-Go/β1/γ23.432025-11-2610.1101/2025.05.26.656101
9KZ2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP67-3.432025-11-2610.1101/2025.05.26.656101
9KZ8APeptideComplement PeptideC3aBMus musculusEP67-Go/β1/γ23.32025-11-2610.1101/2025.05.26.656101
9KZ8 (No Gprot) APeptideComplement PeptideC3aBMus musculusEP67-3.32025-11-2610.1101/2025.05.26.656101
9KZKAPeptideComplement PeptideC3aBMus musculusC3a (fragment)-Go/β1/γ23.542025-11-2610.1101/2025.05.26.656101
9KZK (No Gprot) APeptideComplement PeptideC3aBMus musculusC3a (fragment)-3.542025-11-2610.1101/2025.05.26.656101
9L0HAPeptideComplement PeptideC3aBMus musculusJR14a-Go/β1/γ23.572025-11-2610.1101/2025.05.26.656101
9L0H (No Gprot) APeptideComplement PeptideC3aBMus musculusJR14a-3.572025-11-2610.1101/2025.05.26.656101
9UMJAPeptideComplement PeptideC3aBMus musculusEP54-Go/β1/γ23.382025-11-2610.1101/2025.05.26.656101
9UMJ (No Gprot) APeptideComplement PeptideC3aBMus musculusEP54-3.382025-11-2610.1101/2025.05.26.656101
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWF (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9KUTAPeptideComplement PeptideC3aBHomo sapiensJR14a-Go/β1/γ23.292025-11-2610.1101/2025.05.26.656101
9KUT (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-3.292025-11-2610.1101/2025.05.26.656101
9KV6APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ22.882025-11-2610.1101/2025.05.26.656101
9KV6 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-2.882025-11-2610.1101/2025.05.26.656101
9KV8APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ23.172025-11-2610.1101/2025.05.26.656101
9KV8 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-3.172025-11-2610.1101/2025.05.26.656101




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Download 9KZK_nogp.zip



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