psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S2	L:L:Y1	5.09	No	No	0	0	0
2	L:L:F3	R:R:F164	9.65	No	No	0	0	3
3	L:L:K4	L:L:M6	8.64	No	No	0	0	0
4	L:L:K4	R:R:L333	8.46	No	No	0	0	3
5	L:L:D5	R:R:R171	8.34	No	No	0	0	1
6	L:L:M6	L:L:R10	6.2	No	Yes	0	0	0
7	L:L:M6	R:R:Y174	3.59	No	No	0	0	7
8	L:L:?8	L:L:P7	5.8	Yes	No	0	0	0
9	L:L:P7	R:R:H81	4.58	No	No	0	0	7
10	L:L:P7	R:R:H418	15.25	No	No	0	0	4
11	L:L:?8	L:L:?9	24.87	Yes	No	0	0	0
12	L:L:?8	R:R:S78	7.96	Yes	No	0	0	8
13	L:L:?8	R:R:I98	3.78	Yes	Yes	1	0	8
14	L:L:?8	R:R:I102	5.04	Yes	No	1	0	8
15	L:L:?9	L:L:R10	6.18	No	Yes	0	0	0
16	L:L:?9	R:R:V103	3.03	No	No	0	0	5
17	L:L:R10	R:R:R340	5.33	Yes	No	0	0	9
18	L:L:R10	R:R:Y393	16.46	Yes	Yes	0	0	9
19	L:L:R10	R:R:G397	6	Yes	No	0	0	8
20	L:L:R10	R:R:D417	10.72	Yes	No	0	0	8
21	R:R:V23	R:R:W18	8.58	No	No	0	4	1
22	R:R:Q85	R:R:W18	18.62	No	No	0	5	1
23	R:R:E20	R:R:P21	3.14	No	No	3	4	6
24	R:R:E20	R:R:P22	9.43	No	Yes	3	4	4
25	R:R:E20	R:R:S415	4.31	No	No	3	4	5
26	R:R:P21	R:R:P22	7.79	No	Yes	3	6	4
27	R:R:P22	R:R:S415	3.56	Yes	No	3	4	5
28	R:R:P22	R:R:W416	16.21	Yes	Yes	0	4	7
29	R:R:L82	R:R:V23	7.45	No	No	0	7	4
30	R:R:I29	R:R:L25	5.71	No	No	0	7	5
31	R:R:L25	R:R:V419	5.96	No	No	0	5	5
32	R:R:L30	R:R:S26	3	Yes	No	0	6	8
33	R:R:L82	R:R:S26	3	No	No	0	7	8
34	R:R:M27	R:R:S31	3.07	No	No	0	6	7
35	R:R:L32	R:R:V28	2.98	No	No	0	6	6
36	R:R:A422	R:R:I29	3.25	No	No	0	8	7
37	R:R:L30	R:R:S78	3	Yes	No	0	6	8
38	R:R:A422	R:R:L30	3.15	No	Yes	0	8	6
39	R:R:L30	R:R:S425	3	Yes	No	0	6	8
40	R:R:L75	R:R:T33	2.95	Yes	No	0	9	8
41	R:R:C429	R:R:T33	5.07	Yes	No	0	9	8
42	R:R:F34	R:R:L38	3.65	No	No	0	7	7
43	R:R:C429	R:R:L36	4.76	Yes	No	0	9	8
44	R:R:C429	R:R:G37	3.92	Yes	No	0	9	9
45	R:R:L38	R:R:P39	4.93	No	No	0	7	7
46	R:R:D68	R:R:N41	4.04	Yes	Yes	0	9	9
47	R:R:L69	R:R:N41	4.12	No	Yes	0	7	9
48	R:R:N41	R:R:P432	6.52	Yes	No	0	9	9
49	R:R:T65	R:R:V44	3.17	No	No	0	9	9
50	R:R:A436	R:R:V44	3.39	No	No	0	8	9
51	R:R:F442	R:R:V44	7.87	Yes	No	0	9	9
52	R:R:L45	R:R:T65	2.95	No	No	0	8	9
53	R:R:L45	R:R:L69	4.15	No	No	0	8	7
54	R:R:L50	R:R:W46	5.69	No	Yes	0	4	6
55	R:R:K51	R:R:W46	11.6	Yes	Yes	4	9	6
56	R:R:S449	R:R:W46	3.71	No	Yes	4	9	6
57	R:R:K51	R:R:V47	19.73	Yes	No	0	9	8
58	R:R:F442	R:R:V47	9.18	Yes	No	0	9	8
59	R:R:A48	R:R:L62	3.15	No	No	0	7	8
60	R:R:A48	R:R:F442	4.16	No	Yes	0	7	9
61	R:R:K445	R:R:K51	22.99	Yes	Yes	4	7	9
62	R:R:K51	R:R:S449	12.24	Yes	No	4	9	9
63	R:R:F442	R:R:M52	4.98	Yes	No	0	9	9
64	R:R:K445	R:R:M52	5.76	Yes	No	0	7	9
65	R:R:N57	R:R:T55	8.77	No	No	0	8	9
66	R:R:T55	R:R:T58	6.28	No	No	0	9	8
67	R:R:R134	R:R:V56	3.92	Yes	No	0	9	8
68	R:R:L62	R:R:T58	4.42	No	No	0	8	8
69	R:R:H63	R:R:I59	5.3	Yes	Yes	7	8	6
70	R:R:I59	R:R:V136	3.07	Yes	No	0	6	7
71	R:R:A139	R:R:I59	6.5	No	Yes	0	7	6
72	R:R:C143	R:R:I59	3.27	No	Yes	7	8	6
73	R:R:I116	R:R:W60	3.52	Yes	Yes	0	9	8
74	R:R:A139	R:R:W60	3.89	No	Yes	0	7	8
75	R:R:I142	R:R:W60	5.87	No	Yes	0	5	8
76	R:R:H63	R:R:L112	5.14	Yes	No	0	8	9
77	R:R:C143	R:R:H63	16.22	No	Yes	7	8	8
78	R:R:H63	R:R:W147	7.41	Yes	Yes	0	8	9
79	R:R:D68	R:R:L64	8.14	Yes	No	6	9	9
80	R:R:L64	R:R:S109	3	No	No	6	9	9
81	R:R:L113	R:R:L64	5.54	No	No	0	8	9
82	R:R:L66	R:R:L69	4.15	No	No	0	4	7
83	R:R:D68	R:R:S109	5.89	Yes	No	6	9	9
84	R:R:D68	R:R:S428	5.89	Yes	No	0	9	9
85	R:R:D68	R:R:N431	8.08	Yes	No	0	9	9
86	R:R:L70	R:R:N105	15.1	No	No	0	6	9
87	R:R:C71	R:R:M106	3.24	No	No	0	8	9
88	R:R:C71	R:R:S425	3.44	No	No	0	8	8
89	R:R:C71	R:R:S428	5.16	No	No	0	8	9
90	R:R:C72	R:R:L75	3.17	No	Yes	0	8	9
91	R:R:I102	R:R:S74	9.29	No	No	0	8	9
92	R:R:L75	R:R:S425	6.01	Yes	No	0	9	8
93	R:R:F77	R:R:I98	11.3	No	Yes	0	8	8
94	R:R:G86	R:R:H81	4.77	No	No	0	7	7
95	R:R:H418	R:R:L82	18	No	No	0	4	7
96	R:R:L84	R:R:Q87	7.99	No	No	0	8	6
97	R:R:G86	R:R:Q87	6.58	No	No	0	7	6
98	R:R:H169	R:R:Q87	11.13	No	No	0	3	6
99	R:R:P89	R:R:W88	6.76	No	Yes	1	8	9
100	R:R:W88	R:R:Y90	17.36	Yes	Yes	1	9	7
101	R:R:L94	R:R:W88	4.56	No	Yes	1	8	9
102	R:R:C95	R:R:W88	7.84	No	Yes	1	9	9
103	R:R:C172	R:R:W88	11.75	No	Yes	1	8	9
104	R:R:P89	R:R:Y90	5.56	No	Yes	1	8	7
105	R:R:L94	R:R:Y90	5.86	No	Yes	1	8	7
106	R:R:K96	R:R:R92	4.95	No	No	0	8	1
107	R:R:F93	R:R:L97	4.87	No	No	0	4	6
108	R:R:C172	R:R:C95	7.28	No	No	1	8	9
109	R:R:F158	R:R:K96	4.96	No	No	0	8	8
110	R:R:K96	R:R:R161	6.19	No	Yes	0	8	8
111	R:R:I98	R:R:P99	10.16	Yes	No	0	8	8
112	R:R:I102	R:R:I98	5.89	No	Yes	1	8	8
113	R:R:P99	R:R:R161	11.53	No	Yes	0	8	8
114	R:R:C154	R:R:S100	5.16	No	No	0	8	8
115	R:R:S100	R:R:V157	3.23	No	No	0	8	9
116	R:R:I101	R:R:N105	4.25	No	No	0	5	9
117	R:R:F107	R:R:V103	5.24	No	No	0	8	5
118	R:R:L104	R:R:W147	3.42	No	Yes	0	8	9
119	R:R:C154	R:R:L104	4.76	No	No	0	8	8
120	R:R:M106	R:R:W390	3.49	No	Yes	0	9	9
121	R:R:F107	R:R:M153	6.22	No	No	0	8	8
122	R:R:F107	R:R:R340	6.41	No	No	0	8	9
123	R:R:A108	R:R:W147	7.78	No	Yes	0	9	9
124	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
125	R:R:V110	R:R:W390	4.9	No	Yes	0	9	9
126	R:R:F111	R:R:I146	5.02	No	No	0	8	8
127	R:R:L113	R:R:N431	6.87	No	No	0	8	9
128	R:R:L113	R:R:Y435	9.38	No	Yes	0	8	9
129	R:R:P348	R:R:T114	3.5	Yes	No	0	9	8
130	R:R:I351	R:R:T114	4.56	No	No	0	6	8
131	R:R:I116	R:R:R120	3.76	Yes	No	2	9	9
132	R:R:I116	R:R:Y435	6.04	Yes	Yes	2	9	9
133	R:R:M352	R:R:S117	4.6	No	No	0	8	9
134	R:R:I351	R:R:L118	5.71	No	No	0	6	8
135	R:R:C355	R:R:L118	3.17	No	No	0	9	8
136	R:R:D119	R:R:R134	9.53	No	Yes	0	9	9
137	R:R:R120	R:R:Y356	7.2	No	Yes	2	9	9
138	R:R:R120	R:R:Y435	6.17	No	Yes	2	9	9
139	R:R:C121	R:R:F125	4.19	No	Yes	0	9	6
140	R:R:C121	R:R:C355	7.28	No	No	0	9	9
141	R:R:C121	R:R:I359	3.27	No	No	0	9	9
142	R:R:K126	R:R:L122	7.05	No	No	0	6	7
143	R:R:C130	R:R:L122	4.76	No	No	0	7	7
144	R:R:R134	R:R:V123	3.92	Yes	No	0	9	5
145	R:R:F125	R:R:F358	5.36	Yes	No	0	6	6
146	R:R:F125	R:R:R362	5.34	Yes	No	8	6	7
147	R:R:K126	R:R:W129	12.76	No	Yes	0	6	6
148	R:R:H133	R:R:W129	15.87	No	Yes	0	8	6
149	R:R:H133	R:R:N132	6.38	No	No	0	8	8
150	R:R:F151	R:R:I155	6.28	No	No	0	5	5
151	R:R:M153	R:R:V343	4.56	No	No	0	8	4
152	R:R:I155	R:R:P156	3.39	No	No	0	5	9
153	R:R:I336	R:R:P156	3.39	Yes	No	0	7	9
154	R:R:V159	R:R:Y160	3.79	No	No	0	4	8
155	R:R:P332	R:R:Y160	9.74	No	No	0	4	8
156	R:R:R161	R:R:Y174	15.43	Yes	No	0	8	7
157	R:R:E162	R:R:F164	7	No	No	0	5	3
158	R:R:I163	R:R:N170	9.91	No	No	0	6	4
159	R:R:C172	R:R:I163	3.27	No	No	0	8	6
160	R:R:N170	R:R:T166	5.85	No	No	0	4	1
161	R:R:D167	R:R:N168	5.39	No	No	0	3	5
162	R:R:P332	R:R:T331	3.5	No	No	0	4	4
163	R:R:L401	R:R:V334	2.98	No	No	0	7	4
164	R:R:I336	R:R:R340	3.76	Yes	No	0	7	9
165	R:R:H394	R:R:L341	3.86	Yes	No	0	9	6
166	R:R:L341	R:R:V398	2.98	No	No	0	6	7
167	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
168	R:R:F345	R:R:T391	7.78	No	Yes	0	9	6
169	R:R:F345	R:R:H394	10.18	No	Yes	0	9	9
170	R:R:F386	R:R:M352	16.17	No	No	0	9	8
171	R:R:I353	R:R:V383	3.07	No	No	0	5	8
172	R:R:A379	R:R:Y356	4	No	Yes	0	7	9
173	R:R:V382	R:R:Y356	3.79	Yes	Yes	2	8	9
174	R:R:V383	R:R:Y356	5.05	No	Yes	0	8	9
175	R:R:Y356	R:R:Y435	4.96	Yes	Yes	2	9	9
176	R:R:F376	R:R:V360	5.24	No	Yes	0	4	6
177	R:R:R362	R:R:R365	9.6	No	No	0	7	4
178	R:R:F368	R:R:M363	12.44	No	No	0	5	7
179	R:R:Q364	R:R:Q372	17.92	No	No	0	5	5
180	R:R:R377	R:R:V380	5.23	No	No	0	5	3
181	R:R:L438	R:R:V378	2.98	No	No	0	7	8
182	R:R:V382	R:R:Y435	3.79	Yes	Yes	2	8	9
183	R:R:L434	R:R:V385	4.47	No	No	0	9	7
184	R:R:F386	R:R:W390	3.01	No	Yes	0	9	9
185	R:R:L387	R:R:T391	2.95	No	Yes	0	6	6
186	R:R:C389	R:R:N427	9.45	No	No	0	9	9
187	R:R:W390	R:R:Y393	4.82	Yes	Yes	5	9	9
188	R:R:H394	R:R:W390	7.41	Yes	Yes	5	9	9
189	R:R:A424	R:R:W390	5.19	No	Yes	0	9	9
190	R:R:N427	R:R:W390	13.56	No	Yes	0	9	9
191	R:R:P392	R:R:T391	3.5	No	Yes	0	9	6
192	R:R:I395	R:R:T391	3.04	No	Yes	0	5	6
193	R:R:H394	R:R:Y393	9.8	Yes	Yes	5	9	9
194	R:R:I421	R:R:Y393	3.63	No	Yes	0	4	9
195	R:R:F396	R:R:L413	7.31	No	Yes	0	4	7
196	R:R:F396	R:R:W416	7.02	No	Yes	0	4	7
197	R:R:C420	R:R:F396	6.98	No	No	0	6	4
198	R:R:L402	R:R:V398	2.98	No	No	0	5	7
199	R:R:L399	R:R:L413	6.92	No	Yes	0	9	7
200	R:R:L413	R:R:S400	4.5	Yes	No	0	7	2
201	R:R:L413	R:R:T403	2.95	Yes	No	0	7	2
202	R:R:D404	R:R:P405	4.83	No	No	0	4	4
203	R:R:P408	R:R:T407	3.5	No	No	0	4	7
204	R:R:G410	R:R:L413	3.42	No	Yes	0	3	7
205	R:R:K411	R:R:M414	4.32	No	No	0	2	2
206	R:R:V419	R:R:W416	3.68	No	Yes	0	5	7
207	R:R:N427	R:R:N431	9.54	No	No	0	9	9
208	R:R:C429	R:R:F430	4.19	Yes	No	0	9	7
209	R:R:F433	R:R:L437	3.65	No	No	0	6	7
210	R:R:D441	R:R:K440	5.53	No	No	0	7	7
211	R:R:K444	R:R:Q448	12.2	No	No	0	5	7
212	R:R:K445	R:R:S449	6.12	Yes	No	4	7	9
213	R:R:I450	R:R:R447	5.01	No	No	0	4	5
214	R:R:I101	R:R:I98	2.94	No	Yes	1	5	8
215	R:R:Q372	R:R:V360	2.87	No	Yes	0	5	6
216	R:R:I98	R:R:L94	2.85	Yes	No	1	8	8
217	R:R:L79	R:R:M27	2.83	No	No	0	6	6
218	R:R:C130	R:R:R134	2.79	No	Yes	0	7	9
219	R:R:A426	R:R:F430	2.77	No	No	0	8	7
220	R:R:K445	R:R:Q448	2.71	Yes	No	0	7	7
221	R:R:F111	R:R:V343	2.62	No	No	0	8	4
222	R:R:F125	R:R:V124	2.62	Yes	No	8	6	9
223	R:R:R362	R:R:V124	2.62	No	No	8	7	9
224	R:R:A115	R:R:W60	2.59	No	Yes	0	7	8
225	R:R:R171	R:R:T166	2.59	No	No	0	1	1
226	R:R:F61	R:R:I116	2.51	No	Yes	0	8	9
227	R:R:F34	R:R:L35	2.44	No	No	0	7	6
228	R:R:T412	R:R:W416	2.43	No	Yes	0	6	7
229	R:R:M138	R:R:W129	2.33	No	Yes	0	6	6
230	R:R:L43	R:R:W46	2.28	No	Yes	0	8	6
231	R:R:D119	R:R:W60	2.23	No	Yes	0	9	8
232	R:R:F368	R:R:R367	2.14	No	No	0	5	6
233	R:R:G40	R:R:P39	2.03	No	No	0	9	7
234	R:R:C140	R:R:G137	1.96	No	No	0	4	5
235	R:R:G137	R:R:V136	1.84	No	No	0	5	7
236	R:R:A108	R:R:A67	1.79	No	No	0	9	9
237	R:R:A108	R:R:A150	1.79	No	No	0	9	9
238	L:L:S2	R:R:P405	1.78	No	No	0	0	4
239	R:R:G49	R:R:L62	1.71	No	No	0	7	8
240	R:R:C389	R:R:V385	1.71	No	No	0	9	7
241	R:R:C389	R:R:V388	1.71	No	No	0	9	6
242	R:R:G410	R:R:L409	1.71	No	No	0	3	3
243	R:R:G42	R:R:N41	1.7	No	Yes	0	6	9
244	R:R:A446	R:R:V47	1.7	No	No	0	8	8
245	R:R:G137	R:R:N135	1.7	No	No	0	5	5
246	R:R:A379	R:R:V360	1.7	No	Yes	0	7	6
247	R:R:K126	R:R:P127	1.67	No	No	0	6	9
248	R:R:L75	R:R:P76	1.64	Yes	No	0	9	9
249	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
250	R:R:S349	R:R:V350	1.62	No	No	0	4	4
251	R:R:V148	R:R:V152	1.6	No	No	0	5	5
252	R:R:V378	R:R:V382	1.6	No	Yes	0	8	8
253	R:R:V381	R:R:V382	1.6	No	Yes	0	7	8
254	R:R:T375	R:R:V360	1.59	No	Yes	0	7	6
255	R:R:A436	R:R:L437	1.58	No	No	0	8	7
256	R:R:I24	R:R:V28	1.54	No	No	0	7	6
257	R:R:I338	R:R:V334	1.54	No	No	0	6	4
258	R:R:I338	R:R:V342	1.54	No	No	0	6	6
259	R:R:M363	R:R:S371	1.53	No	No	0	7	7
260	R:R:M27	R:R:V28	1.52	No	No	0	6	6
261	R:R:I336	R:R:T337	1.52	Yes	No	0	7	7
262	R:R:I336	R:R:T339	1.52	Yes	No	0	7	8
263	R:R:A369	R:R:Q364	1.52	No	No	0	5	5
264	R:R:M363	R:R:T375	1.51	No	No	0	7	7
265	R:R:G173	R:R:R161	1.5	No	Yes	0	1	8
266	R:R:G366	R:R:R367	1.5	No	No	0	2	6
267	R:R:L346	R:R:V342	1.49	No	No	0	8	6
268	R:R:G91	R:R:Y90	1.45	No	Yes	0	9	7
269	R:R:D167	R:R:T166	1.45	No	No	0	3	1
270	R:R:I98	R:R:L97	1.43	Yes	No	1	8	6
271	R:R:I101	R:R:L97	1.43	No	No	1	5	6
272	R:R:Q53	R:R:T55	1.42	No	No	0	6	9
273	R:R:G144	R:R:W147	1.41	No	Yes	0	5	9
274	R:R:D441	R:R:M52	1.39	No	No	0	7	9
275	R:R:A354	R:R:F358	1.39	No	No	0	4	6
276	R:R:L30	R:R:L79	1.38	Yes	No	0	6	6
277	R:R:L38	R:R:L73	1.38	No	No	0	7	8
278	R:R:L346	R:R:L347	1.38	No	No	0	8	7
279	R:R:F386	R:R:S349	1.32	No	No	0	9	4
280	R:R:F111	R:R:V149	1.31	No	No	0	8	4
281	R:R:F158	R:R:V159	1.31	No	No	0	8	4
282	R:R:F376	R:R:V380	1.31	No	No	0	4	3
283	R:R:K440	R:R:R443	1.24	No	No	0	7	9
284	R:R:F164	R:R:N170	1.21	No	No	0	3	4
285	R:R:I128	R:R:W129	1.17	No	Yes	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?8	9.49	5	1	0
2	L:L:R10	8.48167	6	0	0
3	R:R:P22	9.2475	4	3	4
4	R:R:L30	2.706	5	0	6
5	R:R:N41	4.095	4	0	9
6	R:R:W46	5.82	4	4	6
7	R:R:K51	16.64	4	4	9
8	R:R:I59	4.535	4	7	6
9	R:R:W60	3.62	5	0	8
10	R:R:H63	8.5175	4	7	8
11	R:R:D68	6.408	5	6	9
12	R:R:L75	3.4425	4	0	9
13	R:R:W88	9.654	5	1	9
14	R:R:Y90	7.5575	4	1	7
15	R:R:I98	5.47857	7	1	8
16	R:R:I116	3.9575	4	2	9
17	R:R:F125	4.3775	4	8	6
18	R:R:W129	8.0325	4	0	6
19	R:R:R134	5.04	4	0	9
20	R:R:W147	5.005	4	0	9
21	R:R:R161	8.6625	4	0	8
22	R:R:I336	2.5475	4	0	7
23	R:R:P348	3.1825	4	0	9
24	R:R:Y356	5	5	2	9
25	R:R:V360	2.85	4	0	6
26	R:R:V382	2.695	4	2	8
27	R:R:W390	6.05429	7	5	9
28	R:R:T391	4.3175	4	0	6
29	R:R:Y393	8.6775	4	5	9
30	R:R:H394	7.8125	4	5	9
31	R:R:L413	5.02	5	0	7
32	R:R:W416	7.335	4	0	7
33	R:R:C429	4.485	4	0	9
34	R:R:Y435	6.068	5	2	9
35	R:R:F442	6.5475	4	0	9
36	R:R:K445	9.395	4	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I163	R:R:N170	13.5687	9.91	No	No	0	6	4
2	R:R:C172	R:R:I163	15.0391	3.27	No	No	0	8	6
3	R:R:C172	R:R:W88	16.4288	11.75	No	Yes	1	8	9
4	R:R:L94	R:R:W88	20.6229	4.56	No	Yes	1	8	9
5	R:R:I98	R:R:L94	26.4673	2.85	Yes	No	1	8	8
6	L:L:?8	R:R:I98	37.8645	3.78	Yes	Yes	1	0	8
7	L:L:?8	L:L:?9	34.7065	24.87	Yes	No	0	0	0
8	L:L:?9	L:L:R10	32.8018	6.18	No	Yes	0	0	0
9	L:L:M6	L:L:R10	15.4113	6.2	No	Yes	0	0	0
10	R:R:R161	R:R:Y174	10.8512	15.43	Yes	No	0	8	7
11	L:L:M6	R:R:Y174	11.6143	3.59	No	No	0	0	7
12	L:L:?8	L:L:P7	11.7384	5.8	Yes	No	0	0	0
13	L:L:?8	R:R:S78	24.6929	7.96	Yes	No	0	0	8
14	L:L:R10	R:R:Y393	53.493	16.46	Yes	Yes	0	0	9
15	R:R:L30	R:R:S78	25.4498	3	Yes	No	0	6	8
16	R:R:A422	R:R:L30	33.1245	3.15	No	Yes	0	8	6
17	R:R:A422	R:R:I29	31.3811	3.25	No	No	0	8	7
18	R:R:I29	R:R:L25	29.6253	5.71	No	No	0	7	5
19	R:R:L25	R:R:V419	27.8571	5.96	No	No	0	5	5
20	R:R:V419	R:R:W416	26.0764	3.68	No	Yes	0	5	7
21	R:R:L30	R:R:L79	11.5337	1.38	Yes	No	0	6	6
22	R:R:L30	R:R:S425	55.0627	3	Yes	No	0	6	8
23	R:R:L75	R:R:S425	17.8062	6.01	Yes	No	0	9	8
24	R:R:L75	R:R:T33	11.9804	2.95	Yes	No	0	9	8
25	R:R:C429	R:R:T33	10.0136	5.07	Yes	No	0	9	8
26	R:R:C71	R:R:S425	62.5078	3.44	No	No	0	8	8
27	R:R:C71	R:R:S428	51.216	5.16	No	No	0	8	9
28	R:R:D68	R:R:S428	51.2346	5.89	Yes	No	0	9	9
29	R:R:D68	R:R:N41	58.6921	4.04	Yes	Yes	0	9	9
30	R:R:L69	R:R:N41	54.0762	4.12	No	Yes	0	7	9
31	R:R:L45	R:R:L69	50.9306	4.15	No	No	0	8	7
32	R:R:L45	R:R:T65	49.3361	2.95	No	No	0	8	9
33	R:R:T65	R:R:V44	47.7292	3.17	No	No	0	9	9
34	R:R:F442	R:R:V44	41.2086	7.87	Yes	No	0	9	9
35	R:R:F442	R:R:V47	12.9855	9.18	Yes	No	0	9	8
36	R:R:F442	R:R:M52	14.8343	4.98	Yes	No	0	9	9
37	R:R:A48	R:R:F442	13.2771	4.16	No	Yes	0	7	9
38	R:R:A48	R:R:L62	11.4096	3.15	No	No	0	7	8
39	R:R:W390	R:R:Y393	50.3661	4.82	Yes	Yes	5	9	9
40	R:R:N427	R:R:W390	61.5399	13.56	No	Yes	0	9	9
41	R:R:N427	R:R:N431	60.0385	9.54	No	No	0	9	9
42	R:R:L113	R:R:N431	71.8141	6.87	No	No	0	8	9
43	R:R:L113	R:R:Y435	100	9.38	No	Yes	0	8	9
44	R:R:I116	R:R:Y435	66.0442	6.04	Yes	Yes	2	9	9
45	R:R:I116	R:R:W60	66.5901	3.52	Yes	Yes	0	9	8
46	R:R:D119	R:R:W60	26.9698	2.23	No	Yes	0	9	8
47	R:R:D119	R:R:R134	25.0651	9.53	No	Yes	0	9	9
48	R:R:A139	R:R:W60	37.182	3.89	No	Yes	0	7	8
49	R:R:A139	R:R:I59	35.2215	6.5	No	Yes	0	7	6
50	R:R:H63	R:R:I59	23.1294	5.3	Yes	Yes	7	8	6
51	R:R:H63	R:R:W147	19.0905	7.41	Yes	Yes	0	8	9
52	R:R:D68	R:R:L64	30.4566	8.14	Yes	No	6	9	9
53	R:R:M106	R:R:W390	13.8851	3.49	No	Yes	0	9	9
54	R:R:C71	R:R:M106	13.5377	3.24	No	No	0	8	9
55	R:R:K96	R:R:R161	10.7644	6.19	No	Yes	0	8	8
56	R:R:V110	R:R:W390	30.5249	4.9	No	Yes	0	9	9
57	R:R:P348	R:R:V110	29.191	3.53	Yes	No	0	9	9
58	R:R:P348	R:R:T114	18.073	3.5	Yes	No	0	9	8
59	R:R:I351	R:R:T114	16.6274	4.56	No	No	0	6	8
60	R:R:I351	R:R:L118	15.1694	5.71	No	No	0	6	8
61	R:R:C355	R:R:L118	13.699	3.17	No	No	0	9	8
62	R:R:C121	R:R:C355	12.2162	7.28	No	No	0	9	9
63	R:R:C130	R:R:R134	19.0905	2.79	No	Yes	0	7	9
64	R:R:C130	R:R:L122	17.0182	4.76	No	No	0	7	7
65	R:R:K126	R:R:L122	14.9336	7.05	No	No	0	6	7
66	R:R:K126	R:R:W129	10.7271	12.76	No	Yes	0	6	6
67	L:L:R10	R:R:R340	16.8445	5.33	Yes	No	0	0	9
68	R:R:Y356	R:R:Y435	32.6467	4.96	Yes	Yes	2	9	9
69	R:R:A379	R:R:Y356	30.9157	4	No	Yes	0	7	9
70	R:R:A379	R:R:V360	28.7753	1.7	No	Yes	0	7	6
71	R:R:T375	R:R:V360	13.5253	1.59	No	Yes	0	7	6
72	R:R:M363	R:R:T375	11.3041	1.51	No	No	0	7	7
73	R:R:F396	R:R:W416	15.1259	7.02	No	Yes	0	4	7
74	R:R:F396	R:R:L413	11.5275	7.31	No	Yes	0	4	7
75	R:R:D68	R:R:N431	46.9909	8.08	Yes	No	0	9	9
76	R:R:L113	R:R:L64	30.4877	5.54	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F3	R:R:F164	9.65	0	No	No	0	3	0	1
L:L:K4	R:R:L333	8.46	0	No	No	0	3	0	1
L:L:D5	R:R:R171	8.34	0	No	No	0	1	0	1
L:L:M6	R:R:Y174	3.59	0	No	No	0	7	0	1
L:L:P7	R:R:H81	4.58	0	No	No	0	7	0	1
L:L:P7	R:R:H418	15.25	0	No	No	0	4	0	1
L:L:?8	R:R:S78	7.96	1	Yes	No	0	8	0	1
L:L:?8	R:R:I98	3.78	1	Yes	Yes	0	8	0	1
L:L:?8	R:R:I102	5.04	1	Yes	No	0	8	0	1
L:L:?9	R:R:V103	3.03	0	No	No	0	5	0	1
L:L:R10	R:R:R340	5.33	0	Yes	No	0	9	0	1
L:L:R10	R:R:Y393	16.46	0	Yes	Yes	0	9	0	1
L:L:R10	R:R:G397	6	0	Yes	No	0	8	0	1
L:L:R10	R:R:D417	10.72	0	Yes	No	0	8	0	1
R:R:L30	R:R:S78	3	0	Yes	No	6	8	2	1
R:R:I102	R:R:S74	9.29	1	No	No	8	9	1	2
R:R:F77	R:R:I98	11.3	0	No	Yes	8	8	2	1
R:R:G86	R:R:H81	4.77	0	No	No	7	7	2	1
R:R:H418	R:R:L82	18	0	No	No	4	7	1	2
R:R:I98	R:R:P99	10.16	1	Yes	No	8	8	1	2
R:R:I102	R:R:I98	5.89	1	No	Yes	8	8	1	1
R:R:P99	R:R:R161	11.53	0	No	Yes	8	8	2	2
R:R:F107	R:R:V103	5.24	0	No	No	8	5	2	1
R:R:F107	R:R:R340	6.41	0	No	No	8	9	2	1
R:R:R161	R:R:Y174	15.43	0	Yes	No	8	7	2	1
R:R:E162	R:R:F164	7	0	No	No	5	3	2	1
R:R:N170	R:R:T166	5.85	0	No	No	4	1	2	2
R:R:I336	R:R:R340	3.76	0	Yes	No	7	9	2	1
R:R:W390	R:R:Y393	4.82	5	Yes	Yes	9	9	2	1
R:R:H394	R:R:W390	7.41	5	Yes	Yes	9	9	2	2
R:R:H394	R:R:Y393	9.8	5	Yes	Yes	9	9	2	1
R:R:I421	R:R:Y393	3.63	0	No	Yes	4	9	2	1
R:R:D404	R:R:P405	4.83	0	No	No	4	4	2	1
R:R:I101	R:R:I98	2.94	1	No	Yes	5	8	2	1
R:R:I98	R:R:L94	2.85	1	Yes	No	8	8	1	2
R:R:R171	R:R:T166	2.59	0	No	No	1	1	1	2
L:L:S2	R:R:P405	1.78	0	No	No	0	4	0	1
R:R:I98	R:R:L97	1.43	1	Yes	No	8	6	1	2
R:R:I101	R:R:L97	1.43	1	No	No	5	6	2	2
R:R:F164	R:R:N170	1.21	0	No	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KZ2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	269
Number of Links	285
Number of Hubs	36
Number of Links mediated by Hubs	143
Number of Communities	8
Number of Nodes involved in Communities	36
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	37412
Length Of Smallest Path	3
Average Path Length	13.6266
Length of Longest Path	28
Minimum Path Strength	1.435
Average Path Strength	5.98274
Maximum Path Strength	21.36
Minimum Path Correlation	0.7
Average Path Correlation	0.918166
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.2693
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.281
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • complement component C3a receptor activity • complement receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • phospholipase C-activating G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • system process • circulatory system process • blood circulation • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • specific granule membrane • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MLE
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	MLE
Name	N-METHYLLEUCINE
Synonyms
Identifier
Formula	C7 H15 N O2
Molecular Weight	145.199
SMILES
PubChem	2777993
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	0


Code	DAL
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	D-Alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>9KZ2_nogp_Chain_R W N E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T T D N H N R C G Y T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KVP	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-	Go/β1/γ2	2.79	2025-11-26	10.1101/2025.05.26.656101
	9KVP (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-		2.79	2025-11-26	10.1101/2025.05.26.656101
	9KZ2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-	Go/β1/γ2	3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-		3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-	Go/β1/γ2	3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZ8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-		3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZK	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-	Go/β1/γ2	3.54	2025-11-26	10.1101/2025.05.26.656101
	9KZK (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-		3.54	2025-11-26	10.1101/2025.05.26.656101
	9L0H	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-	Go/β1/γ2	3.57	2025-11-26	10.1101/2025.05.26.656101
	9L0H (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-		3.57	2025-11-26	10.1101/2025.05.26.656101
	9UMJ	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-	Go/β1/γ2	3.38	2025-11-26	10.1101/2025.05.26.656101
	9UMJ (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-		3.38	2025-11-26	10.1101/2025.05.26.656101
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWF (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9KUT	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Go/β1/γ2	3.29	2025-11-26	10.1101/2025.05.26.656101
	9KUT (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3.29	2025-11-26	10.1101/2025.05.26.656101
	9KV6	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV6 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	3.17	2025-11-26	10.1101/2025.05.26.656101
	9KV8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		3.17	2025-11-26	10.1101/2025.05.26.656101

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