psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S78	7.74	Yes	No	0	0	8
2	L:L:?1	R:R:H81	14.91	Yes	No	0	0	7
3	L:L:?1	R:R:P99	7.41	Yes	No	0	0	8
4	L:L:?1	R:R:I102	6.44	Yes	No	1	0	8
5	L:L:?1	R:R:V103	5.76	Yes	Yes	1	0	5
6	L:L:?1	R:R:M106	3.64	Yes	Yes	1	0	9
7	L:L:?1	R:R:Y174	7.55	Yes	Yes	1	0	7
8	L:L:?1	R:R:R340	8.61	Yes	Yes	1	0	9
9	L:L:?1	R:R:Y393	24.93	Yes	Yes	1	0	9
10	L:L:?1	R:R:D417	12.24	Yes	No	1	0	8
11	L:L:?1	R:R:H418	4.97	Yes	No	0	0	4
12	L:L:?1	R:R:I421	19.31	Yes	No	1	0	4
13	R:R:E20	R:R:V23	9.98	No	No	0	4	4
14	R:R:P21	R:R:P22	5.84	No	No	0	6	4
15	R:R:P22	R:R:S415	3.56	No	No	0	4	5
16	R:R:P22	R:R:W416	13.51	No	No	0	4	7
17	R:R:I29	R:R:L25	5.71	Yes	No	0	7	5
18	R:R:L25	R:R:V419	2.98	No	No	0	5	5
19	R:R:L30	R:R:S26	3	Yes	No	0	6	8
20	R:R:L82	R:R:S26	4.5	No	No	0	7	8
21	R:R:L82	R:R:M27	4.24	No	No	0	7	6
22	R:R:A422	R:R:I29	3.25	No	Yes	0	8	7
23	R:R:L30	R:R:L75	5.54	Yes	Yes	4	6	9
24	R:R:L30	R:R:L79	4.15	Yes	No	0	6	6
25	R:R:A422	R:R:L30	3.15	No	Yes	0	8	6
26	R:R:L75	R:R:T33	4.42	Yes	No	0	9	8
27	R:R:A426	R:R:T33	3.36	No	No	0	8	8
28	R:R:C429	R:R:T33	6.76	No	No	0	9	8
29	R:R:F34	R:R:L38	15.83	Yes	No	0	7	7
30	R:R:F34	R:R:P76	10.11	Yes	No	0	7	9
31	R:R:F433	R:R:L36	4.87	No	No	0	6	8
32	R:R:D68	R:R:N41	6.73	Yes	No	0	9	9
33	R:R:C72	R:R:N41	4.72	No	No	0	8	9
34	R:R:N41	R:R:P432	8.15	No	No	0	9	9
35	R:R:L43	R:R:V47	2.98	No	Yes	0	8	8
36	R:R:T65	R:R:V44	7.93	No	Yes	0	9	9
37	R:R:P432	R:R:V44	3.53	No	Yes	0	9	9
38	R:R:A436	R:R:V44	3.39	No	Yes	5	8	9
39	R:R:F442	R:R:V44	7.87	Yes	Yes	5	9	9
40	R:R:L45	R:R:T65	5.9	No	No	0	8	9
41	R:R:L45	R:R:L66	5.54	No	No	0	8	4
42	R:R:L50	R:R:W46	5.69	No	No	0	4	6
43	R:R:K51	R:R:W46	8.12	No	No	0	9	6
44	R:R:M52	R:R:V47	3.04	No	Yes	0	9	8
45	R:R:F442	R:R:V47	7.87	Yes	Yes	0	9	8
46	R:R:K445	R:R:V47	3.04	Yes	Yes	0	7	8
47	R:R:K445	R:R:K51	5.75	Yes	No	6	7	9
48	R:R:K51	R:R:S449	9.18	No	No	6	9	9
49	R:R:I59	R:R:R54	3.76	Yes	No	0	6	7
50	R:R:L62	R:R:R54	6.07	No	No	0	8	7
51	R:R:T55	R:R:T58	7.85	No	No	0	9	8
52	R:R:R134	R:R:V56	14.38	Yes	No	0	9	8
53	R:R:N57	R:R:R134	4.82	No	Yes	0	8	9
54	R:R:I59	R:R:V136	3.07	Yes	No	0	6	7
55	R:R:A139	R:R:I59	3.25	No	Yes	0	7	6
56	R:R:C140	R:R:I59	4.91	No	Yes	0	4	6
57	R:R:A115	R:R:W60	3.89	No	Yes	0	7	8
58	R:R:D119	R:R:W60	11.17	No	Yes	0	9	8
59	R:R:A139	R:R:W60	3.89	No	Yes	0	7	8
60	R:R:I142	R:R:W60	7.05	No	Yes	0	5	8
61	R:R:C143	R:R:W60	3.92	No	Yes	0	8	8
62	R:R:F61	R:R:Y435	3.09	No	Yes	0	8	9
63	R:R:H63	R:R:L112	3.86	No	No	0	8	9
64	R:R:C143	R:R:H63	16.22	No	No	0	8	8
65	R:R:H63	R:R:W147	7.41	No	No	0	8	9
66	R:R:D68	R:R:L64	4.07	Yes	Yes	2	9	9
67	R:R:L64	R:R:S109	3	Yes	No	2	9	9
68	R:R:L112	R:R:L64	5.54	No	Yes	0	9	9
69	R:R:L113	R:R:L64	5.54	No	Yes	2	8	9
70	R:R:A67	R:R:S109	3.42	No	No	0	9	9
71	R:R:D68	R:R:S109	5.89	Yes	No	2	9	9
72	R:R:D68	R:R:S428	8.83	Yes	No	0	9	9
73	R:R:D68	R:R:N431	9.42	Yes	Yes	2	9	9
74	R:R:C72	R:R:L69	3.17	No	No	0	8	7
75	R:R:L70	R:R:N105	13.73	No	No	0	6	9
76	R:R:C71	R:R:S428	5.16	No	No	0	8	9
77	R:R:I102	R:R:S74	7.74	No	No	0	8	9
78	R:R:F77	R:R:I98	8.79	No	No	0	8	8
79	R:R:H418	R:R:L82	7.71	No	No	0	4	7
80	R:R:H169	R:R:Q87	16.07	No	No	0	3	6
81	R:R:W88	R:R:Y90	22.19	Yes	No	0	9	7
82	R:R:C95	R:R:W88	5.22	Yes	Yes	1	9	9
83	R:R:I163	R:R:W88	3.52	Yes	Yes	1	6	9
84	R:R:N170	R:R:W88	4.52	No	Yes	1	4	9
85	R:R:C172	R:R:W88	9.14	No	Yes	1	8	9
86	R:R:P89	R:R:Y90	6.95	No	No	0	8	7
87	R:R:L94	R:R:Y90	4.69	No	No	0	8	7
88	R:R:K96	R:R:R92	7.43	No	No	0	8	1
89	R:R:F93	R:R:L97	6.09	No	No	0	4	6
90	R:R:I98	R:R:L94	5.71	No	No	0	8	8
91	R:R:C95	R:R:R161	4.18	Yes	Yes	1	9	8
92	R:R:C95	R:R:I163	4.91	Yes	Yes	1	9	6
93	R:R:C172	R:R:C95	5.46	No	Yes	1	8	9
94	R:R:F158	R:R:K96	4.96	No	No	0	8	8
95	R:R:I101	R:R:L97	7.14	No	No	0	5	6
96	R:R:I98	R:R:P99	3.39	No	No	0	8	8
97	R:R:P99	R:R:R161	7.21	No	Yes	0	8	8
98	R:R:C154	R:R:S100	3.44	No	No	0	8	8
99	R:R:F158	R:R:S100	5.28	No	No	0	8	8
100	R:R:I101	R:R:N105	4.25	No	No	0	5	9
101	R:R:I102	R:R:M106	4.37	No	Yes	1	8	9
102	R:R:M106	R:R:V103	3.04	Yes	Yes	1	9	5
103	R:R:F107	R:R:V103	3.93	Yes	Yes	1	8	5
104	R:R:V103	R:R:V157	4.81	Yes	No	0	5	9
105	R:R:C154	R:R:L104	6.35	No	No	0	8	8
106	R:R:M106	R:R:W390	4.65	Yes	Yes	0	9	9
107	R:R:F107	R:R:R340	5.34	Yes	Yes	1	8	9
108	R:R:F107	R:R:G344	3.01	Yes	No	0	8	9
109	R:R:F107	R:R:Y393	3.09	Yes	Yes	1	8	9
110	R:R:A108	R:R:W147	3.89	No	No	0	9	9
111	R:R:P348	R:R:V110	3.53	Yes	No	0	9	9
112	R:R:V110	R:R:W390	7.36	No	Yes	0	9	9
113	R:R:F111	R:R:I146	5.02	No	No	0	8	8
114	R:R:F111	R:R:V149	3.93	No	No	0	8	4
115	R:R:I146	R:R:L112	4.28	No	No	0	8	9
116	R:R:L113	R:R:N431	9.61	No	Yes	2	8	9
117	R:R:L113	R:R:Y435	9.38	No	Yes	2	8	9
118	R:R:S117	R:R:T114	3.2	Yes	Yes	3	9	8
119	R:R:P348	R:R:T114	5.25	Yes	Yes	0	9	8
120	R:R:I351	R:R:T114	4.56	No	Yes	0	6	8
121	R:R:M352	R:R:T114	3.01	No	Yes	3	8	8
122	R:R:I116	R:R:R120	6.26	No	No	2	9	9
123	R:R:I116	R:R:Y435	3.63	No	Yes	2	9	9
124	R:R:M352	R:R:S117	6.13	No	Yes	3	8	9
125	R:R:S117	R:R:Y356	5.09	Yes	Yes	0	9	9
126	R:R:I351	R:R:L118	4.28	No	No	0	6	8
127	R:R:D119	R:R:R134	15.48	No	Yes	0	9	9
128	R:R:R120	R:R:Y356	8.23	No	Yes	0	9	9
129	R:R:R120	R:R:Y435	6.17	No	Yes	2	9	9
130	R:R:C121	R:R:C355	7.28	No	No	0	9	9
131	R:R:C130	R:R:L122	4.76	No	No	0	7	7
132	R:R:C130	R:R:V123	5.12	No	No	7	7	5
133	R:R:R134	R:R:V123	6.54	Yes	No	7	9	5
134	R:R:F125	R:R:V124	6.55	No	No	0	6	9
135	R:R:I359	R:R:V124	7.68	No	No	0	9	9
136	R:R:F125	R:R:F358	5.36	No	No	0	6	6
137	R:R:H133	R:R:W129	20.1	No	No	0	8	6
138	R:R:C130	R:R:R134	5.57	No	Yes	7	7	9
139	R:R:H133	R:R:N132	6.38	No	No	0	8	8
140	R:R:G137	R:R:N135	3.39	No	No	0	5	5
141	R:R:M138	R:R:N135	4.21	No	No	0	6	5
142	R:R:F151	R:R:I155	7.54	No	No	0	5	5
143	R:R:M153	R:R:V343	3.04	No	Yes	0	8	4
144	R:R:I155	R:R:P156	3.39	No	No	0	5	9
145	R:R:I336	R:R:P156	5.08	No	No	0	7	9
146	R:R:V157	R:R:Y174	3.79	No	Yes	0	9	7
147	R:R:V159	R:R:Y160	5.05	No	No	0	4	8
148	R:R:P332	R:R:Y160	8.34	No	No	0	4	8
149	R:R:I336	R:R:Y160	3.63	No	No	0	7	8
150	R:R:C172	R:R:R161	4.18	No	Yes	1	8	8
151	R:R:R161	R:R:Y174	13.38	Yes	Yes	1	8	7
152	R:R:E162	R:R:K175	8.1	No	No	0	5	5
153	R:R:I163	R:R:N170	18.41	Yes	No	1	6	4
154	R:R:R340	R:R:Y174	3.09	Yes	Yes	1	9	7
155	R:R:P332	R:R:T331	3.5	No	No	0	4	4
156	R:R:L401	R:R:V334	4.47	No	No	0	7	4
157	R:R:I338	R:R:T337	3.04	No	No	0	6	7
158	R:R:R340	R:R:Y393	6.17	Yes	Yes	1	9	9
159	R:R:H394	R:R:L341	7.71	No	No	0	9	6
160	R:R:G344	R:R:P348	4.06	No	Yes	0	9	9
161	R:R:F345	R:R:S349	7.93	Yes	No	3	9	4
162	R:R:F345	R:R:F386	3.22	Yes	Yes	3	9	9
163	R:R:F345	R:R:T391	5.19	Yes	No	0	9	6
164	R:R:F345	R:R:H394	15.84	Yes	No	0	9	9
165	R:R:F386	R:R:S349	5.28	Yes	No	3	9	4
166	R:R:F386	R:R:M352	3.73	Yes	No	3	9	8
167	R:R:I353	R:R:V383	3.07	No	No	0	5	8
168	R:R:A379	R:R:Y356	5.34	No	Yes	0	7	9
169	R:R:V382	R:R:Y356	3.79	No	Yes	0	8	9
170	R:R:V383	R:R:Y356	3.79	No	Yes	0	8	9
171	R:R:F376	R:R:V360	3.93	No	No	0	4	6
172	R:R:F361	R:R:Q364	11.71	No	No	0	4	5
173	R:R:R362	R:R:R365	21.32	No	No	0	7	4
174	R:R:F368	R:R:R362	6.41	No	No	0	5	7
175	R:R:F368	R:R:M363	8.71	No	Yes	0	5	7
176	R:R:M363	R:R:Q372	4.08	Yes	No	0	7	5
177	R:R:M363	R:R:T375	10.54	Yes	No	0	7	7
178	R:R:Q364	R:R:Q372	8.96	No	No	0	5	5
179	R:R:F368	R:R:R367	9.62	No	No	0	5	6
180	R:R:F376	R:R:V380	7.87	No	No	0	4	3
181	R:R:L434	R:R:V382	2.98	No	No	0	9	8
182	R:R:V382	R:R:Y435	6.31	No	Yes	0	8	9
183	R:R:L387	R:R:V383	2.98	No	No	0	6	8
184	R:R:L434	R:R:V385	4.47	No	No	0	9	7
185	R:R:F386	R:R:W390	11.02	Yes	Yes	0	9	9
186	R:R:C389	R:R:N427	11.02	No	No	0	9	9
187	R:R:A424	R:R:W390	6.48	No	Yes	0	9	9
188	R:R:N427	R:R:W390	7.91	No	Yes	0	9	9
189	R:R:P392	R:R:T391	6.99	No	No	0	9	6
190	R:R:I395	R:R:T391	6.08	No	No	0	5	6
191	R:R:C420	R:R:P392	3.77	No	No	0	6	9
192	R:R:H394	R:R:Y393	7.62	No	Yes	0	9	9
193	R:R:C420	R:R:F396	6.98	No	No	0	6	4
194	R:R:L399	R:R:L413	4.15	No	Yes	0	9	7
195	R:R:T403	R:R:T407	3.14	No	No	0	2	7
196	R:R:L413	R:R:T403	4.42	Yes	No	0	7	2
197	R:R:D404	R:R:P405	4.83	No	No	0	4	4
198	R:R:D404	R:R:T407	4.34	No	No	0	4	7
199	R:R:P408	R:R:T407	3.5	No	No	0	4	7
200	R:R:G410	R:R:L413	3.42	No	Yes	0	3	7
201	R:R:T412	R:R:W416	3.64	No	No	0	6	7
202	R:R:V419	R:R:W416	6.13	No	No	0	5	7
203	R:R:D417	R:R:I421	7	No	No	1	8	4
204	R:R:N427	R:R:N431	10.9	No	Yes	0	9	9
205	R:R:C429	R:R:F430	4.19	No	No	0	9	7
206	R:R:N431	R:R:Y435	5.81	Yes	Yes	2	9	9
207	R:R:F433	R:R:L437	4.87	No	No	0	6	7
208	R:R:A436	R:R:F442	8.32	No	Yes	5	8	9
209	R:R:R443	R:R:R447	4.26	No	No	0	9	5
210	R:R:K445	R:R:Q448	6.78	Yes	No	0	7	7
211	R:R:K445	R:R:S449	3.06	Yes	No	6	7	9
212	R:R:L409	R:R:T412	2.95	No	No	0	3	6
213	R:R:F433	R:R:P432	2.89	No	No	0	6	9
214	R:R:I29	R:R:L423	2.85	Yes	No	0	7	8
215	R:R:I338	R:R:L401	2.85	No	No	0	6	7
216	R:R:K126	R:R:L122	2.82	No	No	0	6	7
217	R:R:G144	R:R:W147	2.81	No	No	0	5	9
218	R:R:C121	R:R:F125	2.79	No	No	0	9	6
219	R:R:A354	R:R:F358	2.77	No	No	0	4	6
220	R:R:L401	R:R:L402	2.77	No	No	0	7	5
221	R:R:L104	R:R:N105	2.75	No	No	0	8	9
222	R:R:F111	R:R:V343	2.62	No	Yes	0	8	4
223	R:R:R362	R:R:V124	2.62	No	No	0	7	9
224	R:R:I336	R:R:R340	2.51	No	Yes	0	7	9
225	R:R:M138	R:R:R134	2.48	No	Yes	0	6	9
226	R:R:F34	R:R:L35	2.44	Yes	No	0	7	6
227	R:R:F34	R:R:L75	2.44	Yes	Yes	0	7	9
228	R:R:F151	R:R:L104	2.44	No	No	0	5	8
229	R:R:L84	R:R:W88	2.28	No	Yes	0	8	9
230	R:R:L122	R:R:W129	2.28	No	No	0	7	6
231	L:L:?1	R:R:G397	2.2	Yes	No	0	0	8
232	R:R:G37	R:R:P39	2.03	No	No	0	9	7
233	R:R:G40	R:R:P39	2.03	No	No	0	9	7
234	R:R:C72	R:R:G37	1.96	No	No	0	8	9
235	R:R:C429	R:R:G37	1.96	No	No	0	9	9
236	R:R:G397	R:R:S400	1.86	No	No	0	8	2
237	R:R:A108	R:R:A150	1.79	No	No	0	9	9
238	R:R:G91	R:R:I163	1.76	No	Yes	0	9	6
239	R:R:C355	R:R:S117	1.72	No	Yes	0	9	9
240	R:R:C145	R:R:S141	1.72	No	No	0	6	2
241	R:R:G49	R:R:L62	1.71	No	No	0	7	8
242	R:R:C389	R:R:V388	1.71	No	No	0	9	6
243	R:R:A446	R:R:V47	1.7	No	Yes	0	8	8
244	R:R:I128	R:R:P127	1.69	No	No	0	7	9
245	R:R:A48	R:R:T58	1.68	No	No	0	7	8
246	R:R:K126	R:R:P127	1.67	No	No	0	6	9
247	R:R:L347	R:R:P348	1.64	No	Yes	0	7	9
248	R:R:A83	R:R:M27	1.61	No	No	0	5	6
249	R:R:V342	R:R:V343	1.6	No	Yes	0	6	4
250	R:R:V381	R:R:V385	1.6	No	No	0	7	7
251	R:R:T339	R:R:V343	1.59	No	Yes	0	8	4
252	R:R:A48	R:R:L62	1.58	No	No	0	7	8
253	R:R:E20	R:R:P21	1.57	No	No	0	4	6
254	R:R:I353	R:R:S357	1.55	No	No	0	5	6
255	R:R:I24	R:R:V28	1.54	No	No	0	7	6
256	R:R:I29	R:R:V28	1.54	Yes	No	0	7	6
257	R:R:I338	R:R:V342	1.54	No	No	0	6	6
258	R:R:M363	R:R:S371	1.53	Yes	No	0	7	7
259	R:R:K370	R:R:S371	1.53	No	No	0	7	7
260	R:R:I163	R:R:T165	1.52	Yes	No	0	6	4
261	R:R:F442	R:R:G439	1.51	Yes	No	0	9	9
262	R:R:L30	R:R:S425	1.5	Yes	No	4	6	8
263	R:R:L32	R:R:S31	1.5	No	No	0	6	7
264	R:R:L79	R:R:S31	1.5	No	No	0	6	7
265	R:R:L75	R:R:S425	1.5	Yes	No	4	9	8
266	R:R:G173	R:R:R171	1.5	No	No	0	1	1
267	R:R:G366	R:R:R365	1.5	No	No	0	2	4
268	R:R:L413	R:R:S400	1.5	Yes	No	0	7	2
269	R:R:L341	R:R:V398	1.49	No	No	0	6	7
270	R:R:L346	R:R:V342	1.49	No	No	0	8	6
271	R:R:L399	R:R:V398	1.49	No	No	0	9	7
272	R:R:L333	R:R:T337	1.47	No	No	0	3	7
273	R:R:Q372	R:R:V360	1.43	No	No	0	5	6
274	R:R:L38	R:R:L73	1.38	No	No	0	7	8
275	R:R:D441	R:R:K440	1.38	No	No	0	7	7
276	R:R:L84	R:R:Q87	1.33	No	No	0	8	6
277	R:R:N132	R:R:Q131	1.32	No	No	0	8	9
278	R:R:L437	R:R:R443	1.21	No	No	0	7	9
279	R:R:E162	R:R:F164	1.17	No	No	0	5	3
280	R:R:F376	R:R:R377	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.67	13	1	0
2	R:R:I29	3.3375	4	0	7
3	R:R:L30	3.468	5	4	6
4	R:R:F34	7.705	4	0	7
5	R:R:V44	5.68	4	5	9
6	R:R:V47	3.726	5	0	8
7	R:R:I59	3.7475	4	0	6
8	R:R:W60	5.984	5	0	8
9	R:R:L64	4.5375	4	2	9
10	R:R:D68	6.988	5	2	9
11	R:R:L75	3.475	4	4	9
12	R:R:W88	7.81167	6	1	9
13	R:R:C95	4.9425	4	1	9
14	R:R:V103	4.385	4	1	5
15	R:R:M106	3.925	4	1	9
16	R:R:F107	3.8425	4	1	8
17	R:R:T114	4.005	4	3	8
18	R:R:S117	4.035	4	3	9
19	R:R:R134	8.21167	6	7	9
20	R:R:R161	7.2375	4	1	8
21	R:R:I163	6.024	5	1	6
22	R:R:Y174	6.9525	4	1	7
23	R:R:R340	5.144	5	1	9
24	R:R:V343	2.2125	4	0	4
25	R:R:F345	8.045	4	3	9
26	R:R:P348	3.62	4	0	9
27	R:R:Y356	5.248	5	0	9
28	R:R:M363	6.215	4	0	7
29	R:R:F386	5.8125	4	3	9
30	R:R:W390	7.484	5	0	9
31	R:R:Y393	10.4525	4	1	9
32	R:R:L413	3.3725	4	0	7
33	R:R:N431	8.935	4	2	9
34	R:R:Y435	5.73167	6	2	9
35	R:R:F442	6.3925	4	5	9
36	R:R:K445	4.6575	4	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H418	34.8338	4.97	Yes	No	0	0	4
2	R:R:H418	R:R:L82	33.5477	7.71	No	No	0	4	7
3	R:R:L82	R:R:S26	29.7379	4.5	No	No	0	7	8
4	R:R:L30	R:R:S26	28.8409	3	Yes	No	0	6	8
5	R:R:A422	R:R:L30	23.3396	3.15	No	Yes	0	8	6
6	R:R:A422	R:R:I29	21.859	3.25	No	Yes	0	8	7
7	R:R:I29	R:R:L25	15.8282	5.71	Yes	No	0	7	5
8	R:R:L25	R:R:V419	14.2934	2.98	No	No	0	5	5
9	R:R:V419	R:R:W416	12.7479	6.13	No	No	0	5	7
10	R:R:L30	R:R:L75	20.8592	5.54	Yes	Yes	4	6	9
11	R:R:L75	R:R:T33	19.4272	4.42	Yes	No	0	9	8
12	R:R:C429	R:R:T33	19.6758	6.76	No	No	0	9	8
13	L:L:?1	R:R:M106	87.2143	3.64	Yes	Yes	1	0	9
14	R:R:M106	R:R:W390	92.7425	4.65	Yes	Yes	0	9	9
15	R:R:N427	R:R:W390	89.2732	7.91	No	Yes	0	9	9
16	R:R:N427	R:R:N431	89.3867	10.9	No	Yes	0	9	9
17	R:R:D68	R:R:N431	69.9324	9.42	Yes	Yes	2	9	9
18	R:R:D68	R:R:N41	52.548	6.73	Yes	No	0	9	9
19	R:R:N41	R:R:P432	35.7741	8.15	No	No	0	9	9
20	R:R:C72	R:R:N41	25.4418	4.72	No	No	0	8	9
21	R:R:P432	R:R:V44	26.9549	3.53	No	Yes	0	9	9
22	R:R:F442	R:R:V44	19.2326	7.87	Yes	Yes	5	9	9
23	R:R:F442	R:R:V47	16.3091	7.87	Yes	Yes	0	9	8
24	R:R:D68	R:R:L64	48.9976	4.07	Yes	Yes	2	9	9
25	R:R:L112	R:R:L64	100	5.54	No	Yes	0	9	9
26	R:R:H63	R:R:L112	73.5477	3.86	No	No	0	8	9
27	R:R:C143	R:R:H63	64.1178	16.22	No	No	0	8	8
28	R:R:C143	R:R:W60	62.1994	3.92	No	Yes	0	8	8
29	R:R:A139	R:R:W60	21.9346	3.89	No	Yes	0	7	8
30	R:R:A139	R:R:I59	19.7892	3.25	No	Yes	0	7	6
31	R:R:L113	R:R:N431	32.04	9.61	No	Yes	2	8	9
32	R:R:L113	R:R:L64	53.6071	5.54	No	Yes	2	8	9
33	R:R:I59	R:R:R54	13.2883	3.76	Yes	No	0	6	7
34	R:R:L62	R:R:R54	11.0997	6.07	No	No	0	8	7
35	R:R:D119	R:R:W60	36.2551	11.17	No	Yes	0	9	8
36	R:R:D119	R:R:R134	34.3367	15.48	No	Yes	0	9	9
37	R:R:N431	R:R:Y435	22.1183	5.81	Yes	Yes	2	9	9
38	L:L:?1	R:R:R340	25.4256	8.61	Yes	Yes	1	0	9
39	R:R:I336	R:R:R340	30.6728	2.51	No	Yes	0	7	9
40	R:R:I336	R:R:P156	23.0478	5.08	No	No	0	7	9
41	R:R:I155	R:R:P156	21.632	3.39	No	No	0	5	9
42	R:R:F151	R:R:I155	20.0324	7.54	No	No	0	5	5
43	R:R:F151	R:R:L104	18.422	2.44	No	No	0	5	8
44	L:L:?1	R:R:P99	33.2072	7.41	Yes	No	0	0	8
45	R:R:P99	R:R:R161	23.4909	7.21	No	Yes	0	8	8
46	R:R:C95	R:R:R161	31.8671	4.18	Yes	Yes	1	9	8
47	R:R:C95	R:R:W88	16.1146	5.22	Yes	Yes	1	9	9
48	R:R:L84	R:R:W88	19.0921	2.28	No	Yes	0	8	9
49	R:R:L84	R:R:Q87	12.7371	1.33	No	No	0	8	6
50	L:L:?1	R:R:Y174	24.9824	7.55	Yes	Yes	1	0	7
51	R:R:R161	R:R:Y174	30.6133	13.38	Yes	Yes	1	8	7
52	R:R:C172	R:R:R161	19.2326	4.18	No	Yes	1	8	8
53	R:R:C172	R:R:W88	16.1308	9.14	No	Yes	1	8	9
54	R:R:C95	R:R:I163	12.6668	4.91	Yes	Yes	1	9	6
55	R:R:F107	R:R:R340	10.5755	5.34	Yes	Yes	1	8	9
56	R:R:F107	R:R:G344	14.3691	3.01	Yes	No	0	8	9
57	R:R:G344	R:R:P348	14.2016	4.06	No	Yes	0	9	9
58	R:R:I146	R:R:L112	30.1486	4.28	No	No	0	8	9
59	R:R:F111	R:R:I146	28.0465	5.02	No	No	0	8	8
60	R:R:F386	R:R:W390	29.1651	11.02	Yes	Yes	0	9	9
61	R:R:F386	R:R:M352	22.2751	3.73	Yes	No	3	9	8
62	R:R:M352	R:R:S117	19.5082	6.13	No	Yes	3	8	9
63	R:R:P348	R:R:T114	13.3856	5.25	Yes	Yes	0	9	8
64	R:R:S117	R:R:Y356	36.2929	5.09	Yes	Yes	0	9	9
65	R:R:C355	R:R:S117	45.7714	1.72	No	Yes	0	9	9
66	R:R:C121	R:R:C355	43.8854	7.28	No	No	0	9	9
67	R:R:C130	R:R:R134	19.7406	5.57	No	Yes	7	7	9
68	R:R:C130	R:R:L122	17.6331	4.76	No	No	0	7	7
69	R:R:C121	R:R:F125	41.9887	2.79	No	No	0	9	6
70	R:R:F125	R:R:V124	36.2226	6.55	No	No	0	6	9
71	R:R:F111	R:R:V343	23.8098	2.62	No	Yes	0	8	4
72	R:R:V342	R:R:V343	17.4439	1.6	No	Yes	0	6	4
73	R:R:I338	R:R:V342	13.0992	1.54	No	No	0	6	6
74	R:R:F345	R:R:H394	11.1051	15.84	Yes	No	0	9	9
75	R:R:R362	R:R:V124	32.3264	2.62	No	No	0	7	9
76	R:R:F368	R:R:R362	26.582	6.41	No	No	0	5	7
77	R:R:F368	R:R:M363	22.7614	8.71	No	Yes	0	5	7
78	R:R:M363	R:R:Q372	14.6339	4.08	Yes	No	0	7	5
79	R:R:V382	R:R:Y435	22.6263	6.31	No	Yes	0	8	9
80	L:L:?1	R:R:G397	17.0548	2.2	Yes	No	0	0	8
81	R:R:G397	R:R:S400	15.4391	1.86	No	No	0	8	2
82	R:R:L413	R:R:S400	13.6666	1.5	Yes	No	0	7	2
83	R:R:L413	R:R:T403	10.1432	4.42	Yes	No	0	7	2
84	R:R:C72	R:R:G37	22.9343	1.96	No	No	0	8	9
85	R:R:C429	R:R:G37	20.3567	1.96	No	No	0	9	9
86	R:R:R120	R:R:Y435	18.7949	6.17	No	Yes	2	9	9
87	R:R:F345	R:R:F386	12.3318	3.22	Yes	Yes	3	9	9
88	R:R:S117	R:R:T114	11.84	3.2	Yes	Yes	3	9	8
89	R:R:R120	R:R:Y356	18.2491	8.23	No	Yes	0	9	9
90	R:R:V382	R:R:Y356	19.1894	3.79	No	Yes	0	8	9
91	R:R:L113	R:R:Y435	22.3399	9.38	No	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S78	7.74	1	Yes	No	0	8	0	1
L:L:?1	R:R:H81	14.91	1	Yes	No	0	7	0	1
L:L:?1	R:R:P99	7.41	1	Yes	No	0	8	0	1
L:L:?1	R:R:I102	6.44	1	Yes	No	0	8	0	1
L:L:?1	R:R:V103	5.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M106	3.64	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y174	7.55	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R340	8.61	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y393	24.93	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:D417	12.24	1	Yes	No	0	8	0	1
L:L:?1	R:R:H418	4.97	1	Yes	No	0	4	0	1
L:L:?1	R:R:I421	19.31	1	Yes	No	0	4	0	1
R:R:I102	R:R:S74	7.74	1	No	No	8	9	1	2
R:R:H418	R:R:L82	7.71	0	No	No	4	7	1	2
R:R:I98	R:R:P99	3.39	0	No	No	8	8	2	1
R:R:P99	R:R:R161	7.21	0	No	Yes	8	8	1	2
R:R:I102	R:R:M106	4.37	1	No	Yes	8	9	1	1
R:R:M106	R:R:V103	3.04	1	Yes	Yes	9	5	1	1
R:R:F107	R:R:V103	3.93	1	Yes	Yes	8	5	2	1
R:R:V103	R:R:V157	4.81	1	Yes	No	5	9	1	2
R:R:M106	R:R:W390	4.65	1	Yes	Yes	9	9	1	2
R:R:F107	R:R:R340	5.34	1	Yes	Yes	8	9	2	1
R:R:F107	R:R:Y393	3.09	1	Yes	Yes	8	9	2	1
R:R:V157	R:R:Y174	3.79	0	No	Yes	9	7	2	1
R:R:R161	R:R:Y174	13.38	1	Yes	Yes	8	7	2	1
R:R:R340	R:R:Y174	3.09	1	Yes	Yes	9	7	1	1
R:R:R340	R:R:Y393	6.17	1	Yes	Yes	9	9	1	1
R:R:H394	R:R:Y393	7.62	0	No	Yes	9	9	2	1
R:R:D417	R:R:I421	7	1	No	No	8	4	1	1
R:R:I336	R:R:R340	2.51	0	No	Yes	7	9	2	1
L:L:?1	R:R:G397	2.2	1	Yes	No	0	8	0	1
R:R:G397	R:R:S400	1.86	0	No	No	8	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KVP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	254
Number of Links	280
Number of Hubs	36
Number of Links mediated by Hubs	137
Number of Communities	7
Number of Nodes involved in Communities	42
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	47028
Length Of Smallest Path	3
Average Path Length	13.8627
Length of Longest Path	30
Minimum Path Strength	1.49
Average Path Strength	5.90318
Maximum Path Strength	17.2867
Minimum Path Correlation	0.7
Average Path Correlation	0.920109
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	48.6611
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.8694
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • complement component C3a receptor activity • complement receptor activity • immune receptor activity • opsonin receptor activity • complement component C5a receptor activity • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound
Gene Ontology	Biological Process	• cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • regulation of biological process • biological regulation • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • multicellular organism development • tube morphogenesis • anatomical structure development • regulation of anatomical structure morphogenesis • blood vessel development • system development • developmental process • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • phospholipase C-activating G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • immune response-activating cell surface receptor signaling pathway • immune response • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • positive regulation of neutrophil chemotaxis • neutrophil migration • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • neutrophil chemotaxis • positive regulation of neutrophil migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • system process • circulatory system process • blood circulation • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • specific granule membrane • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • specific granule • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q16581
Sequence	>9KVP_nogp_Chain_R E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K M Q R T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G Q W P Y G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K P I W C Q N H R N V G M A C S I C G C I W V V A F V M C I P V F V Y R E I F T N H N R C G Y K T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R G R F A K S Q S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T D P E T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D F R K K A R Q S I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HK2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Gi1/β1/γ2	2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		2.9	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Gi1/β1/γ2	3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK3 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.2	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8IA8	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-	Gi1/β1/γ2	2.86	2023-05-24	To be published
	8IA8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	E7 peptide	-		2.86	2023-05-24	To be published
	8I95	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	Go/β1/γ2	2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I95 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		2.88	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I97 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9A (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP54	-		3.57	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-	Go/β1/γ2	3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9L (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	C3a	-		3.18	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	Go/β1/γ2	3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8I9S (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-		3.26	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-	Go/β1/γ2	3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8J6D (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP141	-		3.1	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	9KVP	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-	Go/β1/γ2	2.79	2025-11-26	10.1101/2025.05.26.656101
	9KVP (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	SB290157	-		2.79	2025-11-26	10.1101/2025.05.26.656101
	9KZ2	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-	Go/β1/γ2	3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ2 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	EP67	-		3.43	2025-11-26	10.1101/2025.05.26.656101
	9KZ8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-	Go/β1/γ2	3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZ8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP67	-		3.3	2025-11-26	10.1101/2025.05.26.656101
	9KZK	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-	Go/β1/γ2	3.54	2025-11-26	10.1101/2025.05.26.656101
	9KZK (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	C3a (fragment)	-		3.54	2025-11-26	10.1101/2025.05.26.656101
	9L0H	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-	Go/β1/γ2	3.57	2025-11-26	10.1101/2025.05.26.656101
	9L0H (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	JR14a	-		3.57	2025-11-26	10.1101/2025.05.26.656101
	9UMJ	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-	Go/β1/γ2	3.38	2025-11-26	10.1101/2025.05.26.656101
	9UMJ (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	EP54	-		3.38	2025-11-26	10.1101/2025.05.26.656101
	9IPV	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPV (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.53	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9IPY	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3.55	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	9ISI	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	-	-	-	3.56	2025-04-23	doi.org/10.1038/s44318-025-00429-w
	8ZWF	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	-	3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWF (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Gi1/β1/γ2	2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	8ZWG (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		2.87	2025-05-14	doi.org/10.1038/s41421-024-00765-x
	9KUT	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-	Go/β1/γ2	3.29	2025-11-26	10.1101/2025.05.26.656101
	9KUT (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Homo sapiens	JR14a	-		3.29	2025-11-26	10.1101/2025.05.26.656101
	9KV6	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV6 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		2.88	2025-11-26	10.1101/2025.05.26.656101
	9KV8	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-	Go/β1/γ2	3.17	2025-11-26	10.1101/2025.05.26.656101
	9KV8 (No Gprot)	A	Peptide	Complement Peptide	C3a_B	Mus musculus	TLQP21	-		3.17	2025-11-26	10.1101/2025.05.26.656101

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