Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:R10 6.734530
2L:L:H14 10.3675430
3L:L:P19 5.68400
4L:L:R21 8.98560
5R:R:F19 5.7475401
6R:R:Q20 6.8575474
7R:R:N41 5.6575409
8R:R:W60 5.53167608
9R:R:L64 4.628529
10R:R:D68 6.404529
11R:R:L75 4.445408
12R:R:W88 7.3825459
13R:R:Y90 10.6425458
14R:R:V110 4.6875419
15R:R:F111 3.718518
16R:R:I116 5.2429
17R:R:H125 7.3025406
18R:R:R134 7.004549
19R:R:W147 4.542509
20R:R:F158 7.4425408
21R:R:R161 9.31754118
22R:R:L163 4.938556
23R:R:R333 7.3925409
24R:R:F338 6.9025419
25R:R:P341 4.0925409
26R:R:Y349 5.81408
27R:R:M356 8.155127
28R:R:F379 6.185419
29R:R:W383 8.408519
30R:R:Y386 8.775408
31R:R:V389 4.49464
32R:R:P398 6.5525433
33R:R:M407 9.38431
34R:R:H411 6.4075404
35R:R:I414 4.385465
36R:R:Y428 6.485629
37R:R:F435 6.196589
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:R10 R:R:G403 43.88184.5YesNo003
2R:R:G403 R:R:V406 50.53253.68NoNo037
3R:R:V389 R:R:V406 63.36534.81YesNo047
4L:L:R21 R:R:V389 34.00963.92YesYes604
5L:L:R21 R:R:I414 41.49095.01YesYes605
6L:L:P18 R:R:I414 43.25885.08NoYes005
7L:L:P18 R:R:H411 40.46336.1NoYes004
8R:R:D23 R:R:H411 11.42173.78NoYes044
9L:L:R10 R:R:P398 10.31424.32YesYes303
10L:L:R10 R:R:E404 13.79664.65YesNo003
11L:L:R10 R:R:M407 10.314211.17YesYes301
12R:R:F164 R:R:I171 19.10011.26NoNo021
13R:R:D162 R:R:F164 22.247111.94NoNo062
14R:R:D162 R:R:L92 25.38341.36NoNo062
15R:R:L163 R:R:L92 28.50915.54YesNo062
16R:R:L163 R:R:W88 40.76683.42YesYes569
17R:R:W88 R:R:Y90 50.005315.43YesYes598
18R:R:F77 R:R:Y90 27.90738.25NoYes088
19R:R:F77 R:R:I98 29.366315.07NoNo088
20R:R:I98 R:R:P99 60.25033.39NoNo088
21R:R:P99 R:R:R161 74.1817.29NoYes088
22R:R:R161 R:R:V157 81.6883.92YesNo1188
23R:R:I103 R:R:V157 96.00644.61NoNo058
24R:R:I103 R:R:R333 1008.77NoYes059
25R:R:R333 R:R:Y386 56.79986.17YesYes098
26L:L:R21 R:R:Y386 69.909517.49YesYes008
27R:R:L94 R:R:Y90 28.083110.55NoYes088
28R:R:I98 R:R:L94 29.54218.56NoNo088
29L:L:P19 R:R:P99 16.84775.84YesNo008
30R:R:H411 R:R:L82 20.244911.57YesNo047
31R:R:L82 R:R:M27 19.22264.24NoNo076
32R:R:H411 R:R:S26 15.41534.18YesNo048
33R:R:A415 R:R:S26 13.5253.42NoNo098
34R:R:I83 R:R:M27 15.22362.92NoNo056
35R:R:I83 R:R:L79 14.24394.28NoNo056
36R:R:G31 R:R:L79 14.06281.71NoNo066
37R:R:G31 R:R:L30 14.00431.71NoNo066
38R:R:L30 R:R:L75 14.04694.15NoYes068
39R:R:C34 R:R:L75 15.96383.17NoYes068
40R:R:H387 R:R:Y386 59.38237.62NoYes098
41R:R:F338 R:R:H387 59.238610.18YesNo099
42R:R:F338 R:R:F379 57.49735.36YesYes199
43R:R:F379 R:R:W383 42.99259.02YesYes199
44R:R:N420 R:R:W383 98.652815.82NoYes099
45R:R:C382 R:R:N420 13.49849.45NoNo099
46R:R:C382 R:R:F423 11.84772.79NoNo096
47R:R:C34 R:R:L38 17.94463.17NoNo067
48R:R:F69 R:R:L38 20.78813.65NoNo077
49R:R:N420 R:R:N424 94.052212.26NoNo099
50R:R:D68 R:R:N424 48.16298.08YesNo099
51R:R:F69 R:R:N41 23.64224.83NoYes079
52R:R:N41 R:R:T65 44.45152.92YesNo099
53R:R:T65 R:R:V44 36.65076.35NoNo099
54R:R:F435 R:R:V44 33.3289.18YesNo899
55R:R:F435 R:R:V47 12.2796.55YesNo098
56R:R:F435 R:R:M52 13.69016.22YesNo099
57R:R:L113 R:R:N424 46.29398.24NoNo099
58R:R:L113 R:R:Y428 35.75088.21NoYes299
59R:R:I116 R:R:Y428 33.24287.25YesYes299
60R:R:I116 R:R:W60 36.94363.52YesYes098
61R:R:D119 R:R:W60 28.040513.4NoYes098
62R:R:D119 R:R:R134 26.68811.91NoYes099
63R:R:D68 R:R:L64 35.92655.43YesYes299
64R:R:L112 R:R:L64 22.98724.15NoYes099
65R:R:L112 R:R:W147 17.84353.42NoYes099
66R:R:L113 R:R:L64 10.04795.54NoYes299
67R:R:K96 R:R:R161 13.71143.71NoYes098
68R:R:F158 R:R:K96 12.034117.37YesNo089
69R:R:F107 R:R:R333 82.80629.62NoYes089
70R:R:F107 R:R:F111 78.46654.29NoYes188
71R:R:F111 R:R:V110 82.31633.93YesYes189
72R:R:F379 R:R:V110 16.57613.93YesYes199
73R:R:P341 R:R:V110 46.93293.53YesYes099
74R:R:P341 R:R:T114 41.61345.25YesNo098
75R:R:I344 R:R:T114 39.97876.08NoNo068
76R:R:I344 R:R:L118 38.63154.28NoNo068
77R:R:C348 R:R:L118 37.85944.76NoNo088
78R:R:C348 R:R:S117 23.98836.89NoNo089
79R:R:M345 R:R:S117 23.46654.6NoNo079
80R:R:R120 R:R:Y428 13.23757.2NoYes299
81R:R:R120 R:R:Y349 17.0669.26NoYes098
82R:R:M345 R:R:Y349 24.29713.59NoYes078
83R:R:V375 R:R:Y428 13.46117.57NoYes099
84R:R:V375 R:R:Y349 12.19915.05NoYes098
85R:R:C121 R:R:C348 49.28125.46NoNo088
86R:R:C121 R:R:H125 20.89465.9NoYes086
87R:R:C130 R:R:R134 14.56344.18NoYes489
88R:R:C130 R:R:L122 13.02984.76NoNo087
89R:R:V157 R:R:Y174 13.43986.31NoNo1188
90R:R:L326 R:R:Y174 15.03192.34NoNo038
91R:R:L326 R:R:P323 13.54638.21NoNo032
92R:R:H125 R:R:R355 11.645410.16YesNo067
93R:R:C121 R:R:I352 27.37493.27NoNo089
94R:R:I352 R:R:M356 25.11182.92NoYes097
95R:R:M356 R:R:R365 16.43244.96YesNo077
96R:R:D434 R:R:M52 10.36742.77NoNo089
97R:R:R357 R:R:R365 14.11613.2NoNo057
98R:R:R357 R:R:V353 11.78912.62NoNo055
99R:R:S413 R:R:Y386 37.46013.82NoYes068
100R:R:S413 R:R:V389 31.52294.85NoYes064
101R:R:L392 R:R:V406 10.36214.47NoNo097
102R:R:A415 R:R:I29 11.62413.25NoNo097
103R:R:E404 R:R:S401 10.36211.44NoNo034
104R:R:D68 R:R:N41 60.13316.73YesYes099
105R:R:V110 R:R:W383 57.10867.36YesYes199
106R:R:L64 R:R:Y428 25.8043.52YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R9 R:R:Q20 4.67 0 No Yes 0 4 0 1
L:L:R10 R:R:P398 4.32 3 Yes Yes 0 3 0 1
L:L:R10 R:R:G403 4.5 3 Yes No 0 3 0 1
L:L:R10 R:R:E404 4.65 3 Yes No 0 3 0 1
L:L:R10 R:R:M407 11.17 3 Yes Yes 0 1 0 1
L:L:F13 R:R:M407 3.73 0 No Yes 0 1 0 1
L:L:H14 R:R:L393 6.43 3 Yes No 0 1 0 1
L:L:H14 R:R:P398 7.63 3 Yes Yes 0 3 0 1
L:L:H14 R:R:M407 18.38 3 Yes Yes 0 1 0 1
L:L:H15 R:R:I171 3.98 0 No No 0 1 0 1
L:L:H15 R:R:R173 6.77 0 No No 0 1 0 1
L:L:P18 R:R:H411 6.1 0 No Yes 0 4 0 1
L:L:P18 R:R:I414 5.08 0 No Yes 0 5 0 1
L:L:P19 R:R:S78 8.91 0 Yes No 0 8 0 1
L:L:P19 R:R:H81 4.58 0 Yes No 0 8 0 1
L:L:P19 R:R:P99 5.84 0 Yes No 0 8 0 1
L:L:P19 R:R:I102 3.39 0 Yes No 0 8 0 1
L:L:R21 R:R:Y386 17.49 6 Yes Yes 0 8 0 1
L:L:R21 R:R:V389 3.92 6 Yes Yes 0 4 0 1
L:L:R21 R:R:D410 15.48 6 Yes No 0 9 0 1
L:L:R21 R:R:I414 5.01 6 Yes Yes 0 5 0 1
R:R:P21 R:R:Q20 4.74 7 No Yes 5 4 2 1
R:R:Q20 R:R:Q22 12.8 7 Yes No 4 4 1 2
R:R:D23 R:R:Q20 5.22 0 No Yes 4 4 2 1
R:R:P21 R:R:Q22 7.9 7 No No 5 4 2 2
R:R:D23 R:R:H411 3.78 0 No Yes 4 4 2 1
R:R:H411 R:R:S26 4.18 0 Yes No 4 8 1 2
R:R:I102 R:R:S74 9.29 0 No No 8 9 1 2
R:R:H411 R:R:L82 11.57 0 Yes No 4 7 1 2
R:R:I98 R:R:P99 3.39 0 No No 8 8 2 1
R:R:P99 R:R:R161 17.29 0 No Yes 8 8 1 2
R:R:R333 R:R:Y386 6.17 0 Yes Yes 9 8 2 1
R:R:H387 R:R:Y386 7.62 0 No Yes 9 8 2 1
R:R:S413 R:R:Y386 3.82 0 No Yes 6 8 2 1
R:R:V389 R:R:V406 4.81 6 Yes No 4 7 1 2
R:R:D410 R:R:V389 4.38 6 No Yes 9 4 1 1
R:R:S413 R:R:V389 4.85 0 No Yes 6 4 2 1
R:R:L393 R:R:M407 4.24 3 No Yes 1 1 1 1
R:R:D397 R:R:P398 4.83 0 No Yes 4 3 2 1
R:R:E399 R:R:P398 9.43 0 No Yes 3 3 2 1
R:R:G403 R:R:V406 3.68 0 No No 3 7 1 2
R:R:D410 R:R:I414 4.2 6 No Yes 9 5 1 1
L:L:A20 R:R:I414 3.25 0 No Yes 0 5 0 1
R:R:G86 R:R:H81 3.18 0 No No 8 8 2 1
L:L:R21 R:R:G390 3 6 Yes No 0 8 0 1
L:L:A16 R:R:H81 2.93 0 No No 0 8 0 1
R:R:I171 R:R:M166 2.92 0 No No 1 2 1 2
R:R:G403 R:R:S400 1.86 0 No No 3 7 1 2
R:R:E404 R:R:S401 1.44 0 No No 3 4 1 2
R:R:F164 R:R:I171 1.26 0 No No 2 1 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9KV6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.39
Number of Linked Nodes 279
Number of Links 306
Number of Hubs 37
Number of Links mediated by Hubs 141
Number of Communities 13
Number of Nodes involved in Communities 57
Number of Links involved in Communities 67
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 53944
Length Of Smallest Path 3
Average Path Length 15.3534
Length of Longest Path 34
Minimum Path Strength 1.475
Average Path Strength 6.54653
Maximum Path Strength 16.485
Minimum Path Correlation 0.7
Average Path Correlation 0.929183
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 47.7032
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.5337
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO09047
Sequence
>9KV6_nogp_Chain_R
LFQPQDIAS MVILGLTCL LGLLGNGLV LWVAGVKMK TTVNTVWFL 
HLTLADFLC CLSLPFSLA HLILQGHWP YGLFLCKLI PSIIILNMF 
ASVFLLTAI SLDRCLIVH KPIWCQNHR NVRTAFAIC GCVWVVAFV 
MCVPVFVYR DLFIMDNRS ICRYVPTPL MAITITRLV VGFLVPFFI 
MVICYSLIV FRMRKTNFT KSRNKTFRV AVAVVTVFF ICWTPYHLV 
GVLLLITDP ESSLGEAVM SWDHMSIAL ASANSCFNP FLYALLGKD 
FRKKARQSI KG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
9KVPAPeptideComplement PeptideC3aBHomo sapiensSB290157-Go/β1/γ22.792025-11-2610.1101/2025.05.26.656101
9KVP (No Gprot) APeptideComplement PeptideC3aBHomo sapiensSB290157-2.792025-11-2610.1101/2025.05.26.656101
9KZ2APeptideComplement PeptideC3aBHomo sapiensEP67-Go/β1/γ23.432025-11-2610.1101/2025.05.26.656101
9KZ2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP67-3.432025-11-2610.1101/2025.05.26.656101
9KZ8APeptideComplement PeptideC3aBMus musculusEP67-Go/β1/γ23.32025-11-2610.1101/2025.05.26.656101
9KZ8 (No Gprot) APeptideComplement PeptideC3aBMus musculusEP67-3.32025-11-2610.1101/2025.05.26.656101
9KZKAPeptideComplement PeptideC3aBMus musculusC3a (fragment)-Go/β1/γ23.542025-11-2610.1101/2025.05.26.656101
9KZK (No Gprot) APeptideComplement PeptideC3aBMus musculusC3a (fragment)-3.542025-11-2610.1101/2025.05.26.656101
9L0HAPeptideComplement PeptideC3aBMus musculusJR14a-Go/β1/γ23.572025-11-2610.1101/2025.05.26.656101
9L0H (No Gprot) APeptideComplement PeptideC3aBMus musculusJR14a-3.572025-11-2610.1101/2025.05.26.656101
9UMJAPeptideComplement PeptideC3aBMus musculusEP54-Go/β1/γ23.382025-11-2610.1101/2025.05.26.656101
9UMJ (No Gprot) APeptideComplement PeptideC3aBMus musculusEP54-3.382025-11-2610.1101/2025.05.26.656101
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWF (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9KUTAPeptideComplement PeptideC3aBHomo sapiensJR14a-Go/β1/γ23.292025-11-2610.1101/2025.05.26.656101
9KUT (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-3.292025-11-2610.1101/2025.05.26.656101
9KV6APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ22.882025-11-2610.1101/2025.05.26.656101
9KV6 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-2.882025-11-2610.1101/2025.05.26.656101
9KV8APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ23.172025-11-2610.1101/2025.05.26.656101
9KV8 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-3.172025-11-2610.1101/2025.05.26.656101




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9KV6_nogp.zip



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