Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?9 5.576520
2L:L:R10 8.6420
3R:R:F19 3.985401
4R:R:L30 2.5325476
5R:R:T33 3.605409
6R:R:L38 2.8425407
7R:R:N41 5.575409
8R:R:A48 2.37406
9R:R:V56 4.7075439
10R:R:W60 6.134508
11R:R:H63 5.45754108
12R:R:L64 5.094519
13R:R:D68 6.648519
14R:R:L75 3.715408
15R:R:H81 6.255408
16R:R:W88 6759
17R:R:C95 5.63459
18R:R:R134 7.326539
19R:R:W147 3.115409
20R:R:R161 9.06667658
21R:R:I165 4.575444
22R:R:C172 6.88459
23R:R:R173 9.895441
24R:R:N175 6.054545
25R:R:P323 3.685462
26R:R:L326 7.8975463
27R:R:P341 4.5275409
28R:R:F342 4.1675403
29R:R:Y349 6.875418
30R:R:F379 5.564509
31R:R:W383 6.274529
32R:R:Y386 6.4728
33R:R:H387 5.07429
34R:R:L394 4.2675467
35R:R:H411 6.77404
36R:R:N424 9.5425419
37R:R:Y428 7.564519
38R:R:L430 2.22407
39R:R:F435 4.2825489
40R:R:K438 13.1675497
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:N175 R:R:Y160 19.85395.81YesNo058
2R:R:V159 R:R:Y160 21.58697.57NoNo048
3R:R:V155 R:R:V159 23.30781.6NoNo054
4R:R:F151 R:R:V155 28.36792.62NoNo065
5R:R:F151 R:R:L104 30.04053.65NoNo067
6R:R:C154 R:R:L104 31.7014.76NoNo077
7R:R:C154 R:R:I103 33.34943.27NoNo075
8R:R:I103 R:R:V157 26.13977.68NoNo058
9R:R:V157 R:R:Y174 22.85496.31NoNo088
10L:L:M6 R:R:Y174 27.2937.18NoNo008
11L:L:M6 R:R:R161 28.74837.44NoYes008
12L:L:L8 R:R:R161 48.35467.29NoYes008
13L:L:?9 L:L:L8 68.21454.22YesNo000
14L:L:?9 L:L:R10 11.81694.94YesYes200
15L:L:R10 R:R:G390 38.94094.5YesNo008
16R:R:G390 R:R:L393 36.78521.71NoNo081
17R:R:L393 R:R:M407 34.55114.24NoNo011
18L:L:K4 R:R:M407 32.46782.88NoNo001
19R:R:I103 R:R:R333 33.452110.02NoNo059
20R:R:F107 R:R:R333 34.03787.48NoNo089
21R:R:F107 R:R:V110 41.23543.93NoNo089
22R:R:F379 R:R:V110 46.63973.93YesNo099
23R:R:F379 R:R:W383 60.21388.02YesYes099
24R:R:W383 R:R:Y386 1003.86YesYes298
25L:L:R10 R:R:Y386 45.510515.43YesYes208
26L:L:R10 R:R:D410 23.40449.53YesNo009
27L:L:P7 R:R:D410 21.7684.83NoNo009
28L:L:L8 R:R:H81 39.30327.71NoYes008
29R:R:H81 R:R:L82 24.48525.14YesNo087
30R:R:H411 R:R:L82 12.627.71YesNo047
31L:L:P7 R:R:H411 20.59057.63NoYes004
32R:R:D23 R:R:H411 23.70637.56NoYes044
33R:R:D23 R:R:Q20 13.10917.83NoNo044
34R:R:P21 R:R:Q20 10.95344.74NoNo054
35R:R:L82 R:R:S78 22.49261.5NoNo078
36R:R:L30 R:R:S78 21.97331.5YesNo068
37R:R:L30 R:R:L75 20.16184.15YesYes068
38R:R:L75 R:R:T33 10.77832.95YesYes089
39R:R:C34 R:R:L75 16.11624.76NoYes068
40R:R:N420 R:R:W383 84.86212.43NoYes099
41R:R:N420 R:R:N424 84.06510.9NoYes099
42R:R:D68 R:R:N424 33.66959.42YesYes199
43R:R:D68 R:R:N41 52.0446.73YesYes099
44R:R:F69 R:R:N41 24.67244.83NoYes079
45R:R:F69 R:R:L38 22.90923.65NoYes077
46R:R:N41 R:R:T65 41.06035.85YesNo099
47R:R:T65 R:R:V44 38.18617.93NoNo099
48R:R:F435 R:R:V44 33.30726.55YesNo899
49R:R:A48 R:R:F435 25.7172.77YesYes069
50R:R:A48 R:R:K438 19.12321.61YesYes067
51R:R:F379 R:R:M345 54.266.22YesNo097
52R:R:M345 R:R:Y349 38.9534.79NoYes178
53R:R:R120 R:R:Y349 49.13357.2NoYes198
54R:R:I116 R:R:R120 39.00137.52NoNo199
55R:R:I116 R:R:W60 92.79033.52NoYes098
56R:R:D119 R:R:W60 63.130214.52NoYes098
57R:R:D119 R:R:R134 40.498811.91NoYes399
58R:R:R134 R:R:V56 13.07896.54YesYes399
59R:R:C143 R:R:W60 21.01325.22NoYes088
60R:R:C143 R:R:H63 18.42888.85NoYes088
61R:R:H63 R:R:W147 13.27823.17YesYes089
62R:R:L64 R:R:N424 26.80398.24YesYes199
63R:R:L113 R:R:N424 24.37659.61NoYes199
64R:R:W88 R:R:Y90 18.507312.54YesNo098
65R:R:P89 R:R:Y90 13.27824.17NoNo088
66R:R:H87 R:R:P89 10.64553.05NoNo068
67R:R:F107 R:R:M153 12.50539.95NoNo088
68R:R:F111 R:R:M153 10.75423.73NoNo088
69R:R:M345 R:R:S117 14.77577.67NoNo179
70R:R:C348 R:R:S117 24.32825.16NoNo089
71R:R:D119 R:R:I123 20.37927NoNo395
72R:R:C121 R:R:C348 21.09787.28NoNo088
73R:R:C121 R:R:I352 10.02963.27NoNo089
74R:R:C130 R:R:I123 17.87334.91NoNo385
75R:R:C130 R:R:R134 18.21155.57NoYes389
76R:R:C130 R:R:L122 30.97044.76NoNo087
77R:R:K126 R:R:L122 25.83781.41NoNo067
78R:R:K126 R:R:P127 10.36771.67NoNo069
79R:R:K126 R:R:W129 10.36771.16NoNo068
80R:R:F176 R:R:Y174 20.8267.22NoNo058
81R:R:F176 R:R:L326 12.14318.27NoYes653
82R:R:F338 R:R:T384 10.415.19NoNo096
83R:R:C382 R:R:N420 11.71439.45NoNo099
84L:L:K4 R:R:P398 25.81971.67NoNo003
85R:R:G403 R:R:P398 18.9242.03NoNo033
86R:R:L64 R:R:Y428 46.54313.52YesYes199
87R:R:I116 R:R:Y428 55.93267.25NoYes199
88R:R:L113 R:R:Y428 23.446710.55NoYes199
89R:R:H81 R:R:W88 24.56984.23YesYes089
90R:R:K96 R:R:R161 14.3471.24NoYes098
91R:R:C34 R:R:L38 16.41813.17NoYes067
92L:L:?9 R:R:Y386 56.797.15YesYes208
93R:R:D68 R:R:L64 23.67016.79YesYes199
94R:R:S117 R:R:Y349 11.04410.17NoYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F3 R:R:I165 3.77 4 No Yes 0 4 0 1
L:L:F3 R:R:R173 19.24 4 No Yes 0 1 0 1
L:L:P5 R:R:I171 10.16 0 No No 0 1 0 1
L:L:M6 R:R:R161 7.44 0 No Yes 0 8 0 1
L:L:M6 R:R:Y174 7.18 0 No No 0 8 0 1
L:L:P7 R:R:D410 4.83 0 No No 0 9 0 1
L:L:P7 R:R:H411 7.63 0 No Yes 0 4 0 1
L:L:L8 R:R:H81 7.71 0 No Yes 0 8 0 1
L:L:L8 R:R:R161 7.29 0 No Yes 0 8 0 1
L:L:?9 L:L:R10 4.94 2 Yes Yes 0 0 0 1
L:L:?9 R:R:M106 4.31 2 Yes No 0 9 0 1
L:L:?9 R:R:Y386 7.15 2 Yes Yes 0 8 0 1
L:L:?9 R:R:I414 7.26 2 Yes No 0 5 0 1
L:L:R10 R:R:Y386 15.43 2 Yes Yes 0 8 1 1
L:L:R10 R:R:G390 4.5 2 Yes No 0 8 1 2
L:L:R10 R:R:D410 9.53 2 Yes No 0 9 1 1
R:R:D23 R:R:H411 7.56 0 No Yes 4 4 2 1
R:R:H411 R:R:S26 4.18 0 Yes No 4 8 1 2
R:R:H81 R:R:L82 5.14 0 Yes No 8 7 1 2
R:R:G86 R:R:H81 7.94 0 No Yes 8 8 2 1
R:R:H81 R:R:W88 4.23 0 Yes Yes 8 9 1 2
R:R:H411 R:R:L82 7.71 0 Yes No 4 7 1 2
R:R:C95 R:R:W88 6.53 5 Yes Yes 9 9 2 2
R:R:C172 R:R:W88 9.14 5 Yes Yes 9 9 2 2
R:R:C95 R:R:R161 4.18 5 Yes Yes 9 8 2 1
R:R:C172 R:R:C95 5.46 5 Yes Yes 9 9 2 2
R:R:P99 R:R:R161 24.5 0 No Yes 8 8 2 1
R:R:I102 R:R:M106 4.37 0 No No 8 9 2 1
R:R:V157 R:R:Y174 6.31 0 No No 8 8 2 1
R:R:C172 R:R:R161 9.75 5 Yes Yes 9 8 2 1
R:R:F164 R:R:I165 3.77 4 No Yes 2 4 2 1
R:R:F164 R:R:R173 11.76 4 No Yes 2 1 2 1
R:R:F164 R:R:N175 4.83 4 No Yes 2 5 2 2
R:R:D167 R:R:I165 7 0 No Yes 3 4 2 1
R:R:I165 R:R:R173 3.76 4 Yes Yes 4 1 1 1
R:R:N175 R:R:R173 4.82 4 Yes Yes 5 1 2 1
R:R:F176 R:R:Y174 7.22 6 No No 5 8 2 1
R:R:W383 R:R:Y386 3.86 2 Yes Yes 9 8 2 1
R:R:H387 R:R:W383 3.17 2 Yes Yes 9 9 2 2
R:R:A417 R:R:W383 3.89 2 No Yes 9 9 2 2
R:R:H387 R:R:Y386 4.36 2 Yes Yes 9 8 2 1
R:R:S413 R:R:Y386 3.82 0 No Yes 6 8 2 1
R:R:I414 R:R:Y386 4.84 2 No Yes 5 8 1 1
R:R:A417 R:R:Y386 5.34 2 No Yes 9 8 2 1
R:R:L393 R:R:M407 4.24 0 No No 1 1 2 1
R:R:D397 R:R:P398 6.44 0 No No 4 3 2 1
L:L:K4 R:R:M407 2.88 0 No No 0 1 0 1
R:R:G403 R:R:P398 2.03 0 No No 3 3 2 1
R:R:G390 R:R:L393 1.71 0 No No 8 1 2 2
L:L:K4 R:R:P398 1.67 0 No No 0 3 0 1
R:R:K96 R:R:R161 1.24 0 No Yes 9 8 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9UMJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.16
Number of Linked Nodes 269
Number of Links 302
Number of Hubs 40
Number of Links mediated by Hubs 147
Number of Communities 10
Number of Nodes involved in Communities 51
Number of Links involved in Communities 65
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 47258
Length Of Smallest Path 3
Average Path Length 13.413
Length of Longest Path 29
Minimum Path Strength 1.24
Average Path Strength 6.06253
Maximum Path Strength 17.125
Minimum Path Correlation 0.7
Average Path Correlation 0.92493
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 48.7673
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.2953
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDAL
PDB ResiduesL:L:?9
Environment DetailsOpen EMBL-EBI Page
CodeDAL
NameD-Alanine
SynonymsD-Alanine
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem71080
Formal Charge0
Total Atoms13
Total Chiral Atoms1
Total Bonds12
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO09047
Sequence
>9UMJ_nogp_Chain_R
PLFQPQDIA SMVILGLTC LLGLLGNGL VLWVAGVKM KTTVNTVWF 
LHLTLADFL CCLSLPFSL AHLILQGHW PYGLFLCKL IPSIIILNM 
FASVFLLTA ISLDRCLIV HKPIWCQNH RNVRTAFAI CGCVWVVAF 
VMCVPVFVY RDLFIMDIC RYNFDVPTP LMAITITRL VVGFLVPFF 
IMVICYSLI VFRMRKTNF TKSRNKTFR VAVAVVTVF FICWTPYHL 
VGVLLLITD PESSLGEAV MSWDHMSIA LASANSCFN PFLYALLGK 
DFRKKARQS I


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HK2APeptideComplement PeptideC3aBHomo sapiensC3a-Gi1/β1/γ22.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-2.92023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3APeptideComplement PeptideC3aBHomo sapiens--Gi1/β1/γ23.22023-05-10doi.org/10.1038/s41589-023-01339-w
8HK3 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.22023-05-10doi.org/10.1038/s41589-023-01339-w
8IA8APeptideComplement PeptideC3aBHomo sapiensE7 peptide-Gi1/β1/γ22.862023-05-24To be published
8IA8 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensE7 peptide-2.862023-05-24To be published
8I95APeptideComplement PeptideC3aBHomo sapiensEP54-Go/β1/γ22.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I95 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-2.882023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97APeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I97 (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9AAPeptideComplement PeptideC3aBHomo sapiensEP54-chim(NtGi1-Gs-CtGq)/β1/γ23.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9A (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP54-3.572023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9LAPeptideComplement PeptideC3aBHomo sapiensC3a-Go/β1/γ23.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9L (No Gprot) APeptideComplement PeptideC3aBHomo sapiensC3a-3.182023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9SAPeptideComplement PeptideC3aBHomo sapiens--Go/β1/γ23.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8I9S (No Gprot) APeptideComplement PeptideC3aBHomo sapiens--3.262023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6DAPeptideComplement PeptideC3aBHomo sapiensEP141-Go/β1/γ23.12023-10-18doi.org/10.1016/j.cell.2023.09.020
8J6D (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP141-3.12023-10-18doi.org/10.1016/j.cell.2023.09.020
9KVPAPeptideComplement PeptideC3aBHomo sapiensSB290157-Go/β1/γ22.792025-11-2610.1101/2025.05.26.656101
9KVP (No Gprot) APeptideComplement PeptideC3aBHomo sapiensSB290157-2.792025-11-2610.1101/2025.05.26.656101
9KZ2APeptideComplement PeptideC3aBHomo sapiensEP67-Go/β1/γ23.432025-11-2610.1101/2025.05.26.656101
9KZ2 (No Gprot) APeptideComplement PeptideC3aBHomo sapiensEP67-3.432025-11-2610.1101/2025.05.26.656101
9KZ8APeptideComplement PeptideC3aBMus musculusEP67-Go/β1/γ23.32025-11-2610.1101/2025.05.26.656101
9KZ8 (No Gprot) APeptideComplement PeptideC3aBMus musculusEP67-3.32025-11-2610.1101/2025.05.26.656101
9KZKAPeptideComplement PeptideC3aBMus musculusC3a (fragment)-Go/β1/γ23.542025-11-2610.1101/2025.05.26.656101
9KZK (No Gprot) APeptideComplement PeptideC3aBMus musculusC3a (fragment)-3.542025-11-2610.1101/2025.05.26.656101
9L0HAPeptideComplement PeptideC3aBMus musculusJR14a-Go/β1/γ23.572025-11-2610.1101/2025.05.26.656101
9L0H (No Gprot) APeptideComplement PeptideC3aBMus musculusJR14a-3.572025-11-2610.1101/2025.05.26.656101
9UMJAPeptideComplement PeptideC3aBMus musculusEP54-Go/β1/γ23.382025-11-2610.1101/2025.05.26.656101
9UMJ (No Gprot) APeptideComplement PeptideC3aBMus musculusEP54-3.382025-11-2610.1101/2025.05.26.656101
9IPVAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPV (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.532025-04-23doi.org/10.1038/s44318-025-00429-w
9IPYAPeptideComplement PeptideC3aBHomo sapiensJR14a--3.552025-04-23doi.org/10.1038/s44318-025-00429-w
9ISIAPeptideComplement PeptideC3aBHomo sapiens---3.562025-04-23doi.org/10.1038/s44318-025-00429-w
8ZWFAPeptideComplement PeptideC3aBHomo sapiensJR14a--32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWF (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-32025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWGAPeptideComplement PeptideC3aBHomo sapiensJR14a-Gi1/β1/γ22.872025-05-14doi.org/10.1038/s41421-024-00765-x
8ZWG (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-2.872025-05-14doi.org/10.1038/s41421-024-00765-x
9KUTAPeptideComplement PeptideC3aBHomo sapiensJR14a-Go/β1/γ23.292025-11-2610.1101/2025.05.26.656101
9KUT (No Gprot) APeptideComplement PeptideC3aBHomo sapiensJR14a-3.292025-11-2610.1101/2025.05.26.656101
9KV6APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ22.882025-11-2610.1101/2025.05.26.656101
9KV6 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-2.882025-11-2610.1101/2025.05.26.656101
9KV8APeptideComplement PeptideC3aBMus musculusTLQP21-Go/β1/γ23.172025-11-2610.1101/2025.05.26.656101
9KV8 (No Gprot) APeptideComplement PeptideC3aBMus musculusTLQP21-3.172025-11-2610.1101/2025.05.26.656101




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