psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q36	R:R:T32	7.09	No	No	0	4	4
2	R:R:T39	R:R:V98	4.76	No	No	0	5	6
3	R:R:L43	R:R:W387	12.53	No	Yes	0	7	8
4	R:R:I47	R:R:L90	7.14	No	No	0	7	8
5	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
6	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
7	R:R:L83	R:R:N54	4.12	Yes	No	0	8	9
8	R:R:N54	R:R:P397	6.52	No	No	0	9	9
9	R:R:A401	R:R:V57	5.09	No	No	0	8	9
10	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
11	R:R:A60	R:R:F411	5.55	No	Yes	0	8	8
12	R:R:F407	R:R:I61	5.02	Yes	No	0	8	8
13	R:R:E64	R:R:S66	5.75	No	No	0	7	6
14	R:R:E64	R:R:L67	3.98	No	Yes	0	7	8
15	R:R:E64	R:R:K413	8.1	No	No	0	7	6
16	R:R:L67	R:R:N72	5.49	Yes	No	2	8	9
17	R:R:F407	R:R:L67	9.74	Yes	Yes	2	8	8
18	R:R:Q68	R:R:Y73	7.89	No	No	0	8	6
19	R:R:N69	R:R:N72	12.26	No	No	0	8	9
20	R:R:R148	R:R:V70	14.38	Yes	No	0	8	7
21	R:R:F407	R:R:N72	9.67	Yes	No	2	8	9
22	R:R:P150	R:R:Y73	4.17	No	No	0	5	6
23	R:R:I130	R:R:L74	4.28	No	Yes	0	9	8
24	R:R:D133	R:R:L74	4.07	No	Yes	0	9	8
25	R:R:L156	R:R:L74	4.15	No	Yes	0	6	8
26	R:R:I75	R:R:Y400	4.84	No	Yes	0	8	9
27	R:R:H126	R:R:S77	9.76	Yes	No	0	8	9
28	R:R:I157	R:R:S77	10.84	No	No	0	8	9
29	R:R:D82	R:R:L78	6.79	Yes	Yes	1	9	9
30	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
31	R:R:L127	R:R:L78	4.15	Yes	Yes	1	8	9
32	R:R:L78	R:R:N396	9.61	Yes	Yes	1	9	9
33	R:R:S122	R:R:T81	6.4	No	Yes	1	8	9
34	R:R:S123	R:R:T81	4.8	No	Yes	0	9	9
35	R:R:H126	R:R:T81	10.95	Yes	Yes	1	8	9
36	R:R:T81	R:R:W161	8.49	Yes	Yes	1	9	9
37	R:R:D82	R:R:S123	4.42	Yes	No	0	9	9
38	R:R:D82	R:R:S393	5.89	Yes	No	0	9	9
39	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
40	R:R:M84	R:R:W161	5.82	No	Yes	0	7	9
41	R:R:S393	R:R:V85	4.85	No	No	0	9	8
42	R:R:L115	R:R:L88	4.15	No	No	0	5	6
43	R:R:F112	R:R:V89	3.93	No	No	1	6	8
44	R:R:D116	R:R:V89	10.22	Yes	No	1	8	8
45	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
46	R:R:L90	R:R:Y390	7.03	No	Yes	0	8	8
47	R:R:M92	R:R:W102	4.65	No	Yes	1	6	9
48	R:R:F112	R:R:M92	11.2	No	No	1	6	6
49	R:R:A93	R:R:Y390	5.34	No	Yes	0	7	8
50	R:R:W102	R:R:Y96	9.65	Yes	No	0	9	6
51	L:L:?1	R:R:Y96	19.94	Yes	No	0	0	6
52	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
53	R:R:Q97	R:R:W387	10.95	No	Yes	1	7	8
54	L:L:?1	R:R:Q97	10.9	Yes	No	1	0	7
55	R:R:L99	R:R:T103	4.42	No	No	0	5	5
56	R:R:D185	R:R:K101	9.68	No	No	0	4	5
57	R:R:L104	R:R:W102	6.83	No	Yes	0	7	9
58	R:R:C109	R:R:W102	5.22	No	Yes	1	9	9
59	R:R:F112	R:R:W102	11.02	No	Yes	1	6	9
60	R:R:C187	R:R:W102	13.06	No	Yes	1	9	9
61	R:R:L104	R:R:T108	7.37	No	No	0	7	6
62	R:R:D110	R:R:Q106	5.22	No	No	0	7	4
63	R:R:C109	R:R:C187	7.28	No	No	1	9	9
64	R:R:D110	R:R:M172	4.16	No	No	0	7	6
65	R:R:L111	R:R:L115	4.15	No	No	0	5	5
66	R:R:I113	R:R:M172	4.37	No	No	0	7	6
67	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
68	R:R:D116	R:R:Y390	11.49	Yes	Yes	1	8	8
69	L:L:?1	R:R:D116	10.26	Yes	Yes	1	0	8
70	R:R:S168	R:R:V117	6.46	No	No	0	8	8
71	L:L:?1	R:R:V117	8.45	Yes	No	0	0	8
72	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
73	R:R:F165	R:R:L118	9.74	No	No	0	5	6
74	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
75	L:L:?1	R:R:C120	6	Yes	No	1	0	7
76	R:R:G164	R:R:T121	3.64	No	Yes	0	8	8
77	R:R:I167	R:R:T121	7.6	No	Yes	0	8	8
78	R:R:A203	R:R:T121	5.03	No	Yes	0	8	8
79	L:L:?1	R:R:T121	3.71	Yes	Yes	0	0	8
80	R:R:H126	R:R:S122	4.18	Yes	No	1	8	8
81	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
82	R:R:F354	R:R:I124	3.77	Yes	No	1	9	8
83	R:R:I124	R:R:W358	9.4	No	Yes	1	8	8
84	R:R:C128	R:R:W125	3.92	No	No	3	7	7
85	R:R:I163	R:R:W125	21.14	No	No	0	5	7
86	R:R:P207	R:R:W125	13.51	No	No	3	9	7
87	R:R:H126	R:R:T160	13.69	Yes	No	0	8	8
88	R:R:H126	R:R:W161	4.23	Yes	Yes	1	8	9
89	R:R:F354	R:R:L127	4.87	Yes	Yes	1	9	8
90	R:R:L127	R:R:N396	8.24	Yes	Yes	1	8	9
91	R:R:L127	R:R:Y400	5.86	Yes	Yes	1	8	9
92	R:R:C128	R:R:P207	3.77	No	No	3	7	9
93	R:R:C128	R:R:L210	6.35	No	No	0	7	7
94	R:R:A129	R:R:L156	6.3	No	No	0	8	6
95	R:R:I130	R:R:R134	6.26	No	No	0	9	9
96	R:R:A131	R:R:Y215	5.34	No	Yes	0	9	9
97	R:R:L132	R:R:W136	10.25	No	No	0	6	5
98	R:R:L132	R:R:L214	5.54	No	No	0	6	7
99	R:R:D133	R:R:R148	11.91	No	Yes	0	9	8
100	R:R:R134	R:R:Y215	4.12	No	Yes	0	9	9
101	R:R:R134	R:R:Y400	5.14	No	Yes	0	9	9
102	R:R:W136	R:R:Y135	4.82	No	Yes	0	5	9
103	R:R:T139	R:R:Y135	16.23	No	Yes	0	8	9
104	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
105	R:R:R217	R:R:Y135	10.29	No	Yes	0	7	9
106	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
107	R:R:I138	R:R:I218	4.42	No	No	0	9	9
108	R:R:D140	R:R:D143	6.65	No	No	0	7	6
109	R:R:D143	R:R:K147	6.91	No	No	0	6	5
110	R:R:D143	R:R:R152	13.1	No	No	0	6	7
111	R:R:R148	R:R:Y144	13.38	Yes	No	0	8	8
112	R:R:N146	R:R:V145	4.43	No	No	0	5	6
113	R:R:K147	R:R:N146	5.6	No	No	0	5	5
114	R:R:R148	R:R:R152	7.46	Yes	No	0	8	7
115	R:R:I167	R:R:Y198	3.63	No	No	0	8	5
116	R:R:I169	R:R:S168	6.19	No	No	0	6	8
117	R:R:P170	R:R:P171	5.84	No	No	0	8	7
118	R:R:P171	R:R:Y195	5.56	No	Yes	0	7	8
119	R:R:G174	R:R:W175	4.22	No	No	0	5	6
120	R:R:D183	R:R:P184	6.44	No	No	0	1	1
121	R:R:A186	R:R:D183	4.63	No	No	0	4	1
122	R:R:I189	R:R:Y195	6.04	No	Yes	0	6	8
123	R:R:S190	R:R:Y195	3.82	No	Yes	0	6	8
124	R:R:F370	R:R:H193	19.23	No	No	0	5	4
125	R:R:S199	R:R:Y195	10.17	No	Yes	0	8	8
126	R:R:P369	R:R:T196	10.49	No	No	0	7	7
127	R:R:F201	R:R:I197	5.02	No	No	0	5	7
128	R:R:F370	R:R:I197	5.02	No	No	0	5	7
129	L:L:?1	R:R:S199	3.78	Yes	No	0	0	8
130	R:R:T200	R:R:Y205	4.99	Yes	Yes	0	7	7
131	R:R:F362	R:R:T200	3.89	Yes	Yes	0	7	7
132	R:R:F204	R:R:Y205	9.28	Yes	Yes	0	8	7
133	R:R:F204	R:R:L208	7.31	Yes	No	1	8	7
134	R:R:F204	R:R:F354	5.36	Yes	Yes	1	8	9
135	R:R:F204	R:R:L359	6.09	Yes	No	0	8	7
136	R:R:F204	R:R:F362	22.51	Yes	Yes	1	8	7
137	R:R:L366	R:R:Y205	7.03	No	Yes	0	7	7
138	R:R:L208	R:R:L212	4.15	No	No	0	7	6
139	R:R:F354	R:R:L208	3.65	Yes	No	1	9	7
140	R:R:L210	R:R:L214	5.54	No	No	0	7	7
141	R:R:M211	R:R:Y215	4.79	No	Yes	0	9	9
142	R:R:M211	R:R:M351	4.33	No	No	0	9	8
143	R:R:F354	R:R:M211	3.73	Yes	No	0	9	9
144	R:R:L212	R:R:M351	4.24	No	No	0	6	8
145	R:R:R217	R:R:V213	3.92	No	No	0	7	5
146	R:R:I218	R:R:Y215	4.84	No	Yes	0	9	9
147	R:R:I350	R:R:Y215	6.04	No	Yes	0	8	9
148	R:R:F219	R:R:R223	6.41	Yes	No	0	6	7
149	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
150	R:R:R223	R:R:R227	10.66	No	No	0	7	6
151	R:R:F224	R:R:R225	8.55	No	No	4	6	7
152	R:R:F224	R:R:K228	3.72	No	No	4	6	5
153	R:R:K228	R:R:R225	7.43	No	No	4	5	7
154	R:R:I226	R:R:R339	5.01	No	No	0	6	7
155	R:R:E340	R:R:I226	5.47	No	No	0	8	6
156	R:R:E340	R:R:R227	9.3	No	No	0	8	6
157	R:R:K332	R:R:V230	7.59	No	No	0	6	3
158	R:R:A336	R:R:V230	5.09	No	No	0	5	3
159	R:R:E326	R:R:K324	6.75	No	No	0	3	1
160	R:R:N328	R:R:R327	13.26	No	No	0	3	3
161	R:R:E330	R:R:R333	13.96	No	No	0	4	4
162	R:R:K334	R:R:R333	6.19	No	No	0	5	4
163	R:R:M335	R:R:R339	9.93	No	No	0	4	7
164	R:R:I349	R:R:I399	4.42	No	No	0	7	8
165	R:R:L395	R:R:T353	4.42	No	No	0	6	7
166	R:R:I399	R:R:T353	6.08	No	No	0	8	7
167	R:R:F354	R:R:W358	4.01	Yes	Yes	1	9	8
168	R:R:C357	R:R:N392	9.45	No	No	0	8	9
169	R:R:F361	R:R:W358	6.01	Yes	Yes	1	8	8
170	R:R:F362	R:R:W358	9.02	Yes	Yes	1	7	8
171	R:R:G389	R:R:W358	8.44	No	Yes	0	8	8
172	R:R:N392	R:R:W358	7.91	No	Yes	0	9	8
173	R:R:I363	R:R:L359	7.14	No	No	0	7	7
174	R:R:F361	R:R:F362	9.65	Yes	Yes	1	8	7
175	R:R:F361	R:R:I385	3.77	Yes	No	0	8	6
176	R:R:F361	R:R:N386	4.83	Yes	No	1	8	7
177	L:L:?1	R:R:F361	14.58	Yes	Yes	1	0	8
178	L:L:?1	R:R:F362	8.44	Yes	Yes	1	0	7
179	R:R:M377	R:R:V364	4.56	Yes	No	0	4	6
180	R:R:E372	R:R:S373	4.31	No	No	0	3	3
181	R:R:M377	R:R:P378	5.03	Yes	No	0	4	7
182	R:R:L381	R:R:M377	4.24	No	Yes	0	6	4
183	R:R:I384	R:R:L380	4.28	No	No	0	4	3
184	L:L:?1	R:R:N386	7.79	Yes	No	1	0	7
185	R:R:W387	R:R:Y390	8.68	Yes	Yes	1	8	8
186	L:L:?1	R:R:W387	4.31	Yes	Yes	1	0	8
187	L:L:?1	R:R:Y390	11.82	Yes	Yes	1	0	8
188	R:R:N392	R:R:N396	10.9	No	Yes	0	9	9
189	R:R:N396	R:R:Y400	4.65	Yes	Yes	1	9	9
190	R:R:P397	R:R:Y402	4.17	No	Yes	0	9	6
191	R:R:F403	R:R:V398	3.93	No	No	0	8	6
192	R:R:I399	R:R:Y400	9.67	No	Yes	0	8	9
193	R:R:A401	R:R:F407	8.32	No	Yes	0	8	8
194	R:R:F411	R:R:Y402	8.25	Yes	Yes	0	8	6
195	R:R:D406	R:R:N404	5.39	No	No	0	7	9
196	R:R:F407	R:R:N404	10.87	Yes	No	0	8	9
197	R:R:K405	R:R:Q408	9.49	No	No	0	6	9
198	R:R:P150	R:R:V70	3.53	No	No	0	5	7
199	R:R:L347	R:R:Y215	3.52	No	Yes	0	8	9
200	R:R:P150	R:R:T149	3.5	No	No	0	5	8
201	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
202	R:R:A50	R:R:S86	3.42	No	No	0	8	8
203	R:R:A79	R:R:V57	3.39	No	No	0	9	9
204	R:R:I206	R:R:P207	3.39	No	No	0	6	9
205	R:R:I385	R:R:P360	3.39	No	No	0	6	9
206	R:R:K191	R:R:P369	3.35	No	No	0	5	7
207	R:R:C109	R:R:I113	3.27	No	No	1	9	7
208	R:R:C187	R:R:I113	3.27	No	No	1	9	7
209	R:R:S393	R:R:S86	3.26	No	No	0	9	8
210	R:R:C119	R:R:M84	3.24	No	No	0	7	7
211	R:R:D140	R:R:P141	3.22	No	No	0	7	8
212	R:R:V58	R:R:V80	3.21	No	No	0	7	7
213	R:R:C56	R:R:L52	3.17	No	No	0	8	4
214	R:R:A94	R:R:L43	3.15	No	No	0	7	7
215	R:R:A50	R:R:L394	3.15	No	No	0	8	7
216	R:R:A410	R:R:L67	3.15	No	Yes	0	8	8
217	R:R:A153	R:R:L74	3.15	No	Yes	0	7	8
218	R:R:T196	R:R:T200	3.14	No	Yes	0	7	7
219	R:R:F201	R:R:Y205	3.09	No	Yes	0	5	7
220	R:R:I350	R:R:T346	3.04	No	No	0	8	8
221	R:R:K101	R:R:T103	3	No	No	0	5	5
222	R:R:L83	R:R:V51	2.98	Yes	No	0	8	7
223	R:R:L83	R:R:V87	2.98	Yes	No	0	8	6
224	R:R:L88	R:R:V87	2.98	No	No	0	6	6
225	R:R:L368	R:R:V364	2.98	No	No	0	4	6
226	R:R:L43	R:R:T39	2.95	No	No	0	7	5
227	R:R:I355	R:R:M351	2.92	No	No	0	7	8
228	R:R:I349	R:R:K345	2.91	No	No	0	7	7
229	R:R:I414	R:R:L63	2.85	No	No	0	7	6
230	R:R:I163	R:R:L159	2.85	No	No	0	5	3
231	R:R:I355	R:R:L356	2.85	No	No	0	7	5
232	R:R:I142	R:R:N146	2.83	No	No	0	6	5
233	R:R:G105	R:R:W102	2.81	No	Yes	0	7	9
234	R:R:K412	R:R:N409	2.8	No	No	0	6	6
235	R:R:C56	R:R:F411	2.79	No	Yes	0	8	8
236	R:R:L95	R:R:L99	2.77	No	No	0	6	5
237	R:R:A338	R:R:R341	2.77	No	No	0	5	6
238	R:R:A137	R:R:Y144	2.67	No	No	0	8	8
239	R:R:D183	R:R:D185	2.66	No	No	0	1	4
240	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
241	R:R:V398	R:R:Y402	2.52	No	Yes	0	6	6
242	R:R:T39	R:R:Y35	2.5	No	No	0	5	4
243	R:R:F48	R:R:L52	2.44	No	No	0	4	4
244	R:R:L337	R:R:R333	2.43	No	No	0	5	4
245	R:R:L166	R:R:Y198	2.34	No	No	0	5	5
246	R:R:E326	R:R:R327	2.33	No	No	0	3	3
247	R:R:L46	R:R:W387	2.28	No	Yes	0	7	8
248	R:R:A79	R:R:G76	1.95	No	No	0	9	6
249	R:R:C371	R:R:C375	1.82	No	No	0	5	4
250	R:R:G202	R:R:I167	1.76	No	No	0	5	8
251	R:R:G352	R:R:I355	1.76	No	No	0	6	7
252	R:R:G382	R:R:I385	1.76	No	No	0	4	6
253	R:R:G382	R:R:M377	1.75	No	Yes	0	4	4
254	R:R:C357	R:R:S391	1.72	No	No	0	8	5
255	R:R:C371	R:R:S374	1.72	No	No	0	5	5
256	R:R:A114	R:R:S168	1.71	No	No	0	7	8
257	R:R:G174	R:R:L173	1.71	No	No	0	5	6
258	R:R:C371	R:R:V367	1.71	No	No	0	5	6
259	R:R:A79	R:R:V58	1.7	No	No	0	9	7
260	R:R:C49	R:R:T45	1.69	No	No	0	5	4
261	R:R:A221	R:R:T139	1.68	No	No	0	6	8
262	R:R:A186	R:R:T188	1.68	No	No	0	4	5
263	R:R:D192	R:R:G194	1.68	No	No	0	6	5
264	R:R:A365	R:R:T200	1.68	No	Yes	0	8	7
265	R:R:A222	R:R:T343	1.68	No	No	0	8	8
266	R:R:L90	R:R:P91	1.64	No	No	0	8	9
267	R:R:S40	R:R:V98	1.62	No	No	0	5	6
268	R:R:A336	R:R:I226	1.62	No	No	0	5	6
269	R:R:C49	R:R:L394	1.59	No	No	0	5	7
270	R:R:T229	R:R:V230	1.59	No	No	0	4	3
271	R:R:T343	R:R:V344	1.59	No	No	0	8	8
272	R:R:C375	R:R:L368	1.59	No	No	0	4	4
273	R:R:A55	R:R:L83	1.58	No	Yes	0	5	8
274	R:R:A71	R:R:N69	1.56	No	No	0	8	8
275	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
276	R:R:L162	R:R:S158	1.5	No	No	0	5	5
277	R:R:K191	R:R:T188	1.5	No	No	0	5	5
278	R:R:G216	R:R:R220	1.5	No	No	0	3	5
279	R:R:K342	R:R:T346	1.5	No	No	0	8	8
280	R:R:L388	R:R:S391	1.5	No	No	0	8	5
281	R:R:L209	R:R:V213	1.49	No	No	0	5	5
282	R:R:I414	R:R:I415	1.47	No	No	0	7	7
283	R:R:Q106	R:R:S182	1.44	No	No	0	4	3
284	R:R:K324	R:R:N325	1.4	No	No	0	1	5
285	R:R:D406	R:R:N409	1.35	No	No	0	7	6
286	R:R:R151	R:R:T149	1.29	No	No	0	6	8
287	R:R:F411	R:R:I414	1.26	Yes	No	0	8	7
288	R:R:L337	R:R:R341	1.21	No	No	0	5	6
289	R:R:Q68	R:R:R65	1.17	No	No	0	8	7
290	R:R:Q36	R:R:Y35	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L67	5.59	4	2	8
2	R:R:L74	3.9125	4	0	8
3	R:R:L78	7.065	4	1	9
4	R:R:T81	7.66	4	1	9
5	R:R:D82	6.382	5	1	9
6	R:R:L83	2.915	4	0	8
7	R:R:W102	7.60571	7	1	9
8	R:R:D116	9.16	4	1	8
9	R:R:T121	4.995	4	0	8
10	R:R:H126	8.42	6	1	8
11	R:R:L127	5.78	4	1	8
12	R:R:Y135	8.166	5	0	9
13	R:R:R148	11.7825	4	0	8
14	R:R:W161	8.552	5	1	9
15	R:R:Y195	5.808	5	0	8
16	R:R:T200	3.425	4	0	7
17	R:R:F204	10.11	5	1	8
18	R:R:Y205	6.0975	4	0	7
19	R:R:Y215	4.775	6	0	9
20	R:R:F219	3.5475	4	0	6
21	R:R:F354	4.23167	6	1	9
22	R:R:W358	7.14429	7	1	8
23	R:R:F361	7.768	5	1	8
24	R:R:F362	10.702	5	1	7
25	R:R:M377	3.895	4	0	4
26	R:R:W387	7.75	5	1	8
27	R:R:Y390	8.025	6	1	8
28	R:R:N396	8.296	5	1	9
29	R:R:Y400	6.032	5	1	9
30	R:R:Y402	4.868	5	0	6
31	R:R:F407	8.724	5	2	8
32	R:R:F411	4.4625	4	0	8
33	L:L:?1	9.165	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T39	R:R:Y35	10.9308	2.5	No	No	0	5	4
2	R:R:L43	R:R:T39	21.7916	2.95	No	No	0	7	5
3	R:R:L43	R:R:W387	28.8262	12.53	No	Yes	0	7	8
4	R:R:L90	R:R:Y390	13.682	7.03	No	Yes	0	8	8
5	R:R:P397	R:R:Y402	47.3105	4.17	No	Yes	0	9	6
6	R:R:N54	R:R:P397	48.6532	6.52	No	No	0	9	9
7	R:R:D82	R:R:N54	59.098	6.73	Yes	No	0	9	9
8	R:R:D82	R:R:N396	63.7685	8.08	Yes	Yes	1	9	9
9	R:R:N392	R:R:N396	83.612	10.9	No	Yes	0	9	9
10	R:R:N392	R:R:W358	85.9514	7.91	No	Yes	0	9	8
11	R:R:C120	R:R:W358	58.8221	5.22	No	Yes	1	7	8
12	L:L:?1	R:R:C120	49.9588	6	Yes	No	1	0	7
13	L:L:?1	R:R:W387	35.4077	4.31	Yes	Yes	1	0	8
14	R:R:F361	R:R:W358	62.4094	6.01	Yes	Yes	1	8	8
15	L:L:?1	R:R:F361	52.8048	14.58	Yes	Yes	1	0	8
16	R:R:F362	R:R:W358	63.6532	9.02	Yes	Yes	1	7	8
17	L:L:?1	R:R:F362	84.9835	8.44	Yes	Yes	1	0	7
18	R:R:L83	R:R:N54	11.0667	4.12	Yes	No	0	8	9
19	R:R:A401	R:R:V57	23.2249	5.09	No	No	0	8	9
20	R:R:V57	R:R:Y402	30.556	5.05	No	Yes	0	9	6
21	R:R:F411	R:R:Y402	12.6153	8.25	Yes	Yes	0	8	6
22	R:R:A401	R:R:F407	21.7339	8.32	No	Yes	0	8	8
23	R:R:F354	R:R:W358	100	4.01	Yes	Yes	1	9	8
24	R:R:F354	R:R:L127	65.8402	4.87	Yes	Yes	1	9	8
25	R:R:L127	R:R:Y400	43.8674	5.86	Yes	Yes	1	8	9
26	R:R:R134	R:R:Y400	76.2026	5.14	No	Yes	0	9	9
27	R:R:I130	R:R:R134	93.5049	6.26	No	No	0	9	9
28	R:R:I130	R:R:L74	89.7035	4.28	No	Yes	0	9	8
29	R:R:D133	R:R:L74	74.4152	4.07	No	Yes	0	9	8
30	R:R:D133	R:R:R148	70.5725	11.91	No	Yes	0	9	8
31	R:R:R148	R:R:V70	27.7595	14.38	Yes	No	0	8	7
32	R:R:P150	R:R:V70	23.818	3.53	No	No	0	5	7
33	R:R:P150	R:R:Y73	11.944	4.17	No	No	0	5	6
34	R:R:F204	R:R:F362	38.7809	22.51	Yes	Yes	1	8	7
35	R:R:F204	R:R:F354	48.6697	5.36	Yes	Yes	1	8	9
36	R:R:N396	R:R:Y400	47.4423	4.65	Yes	Yes	1	9	9
37	R:R:F354	R:R:M211	93.3402	3.73	Yes	No	0	9	9
38	R:R:M211	R:R:Y215	86.3385	4.79	No	Yes	0	9	9
39	R:R:R134	R:R:Y215	50.9061	4.12	No	Yes	0	9	9
40	R:R:H126	R:R:L78	33.5626	7.71	Yes	Yes	1	8	9
41	R:R:L127	R:R:L78	24.4975	4.15	Yes	Yes	1	8	9
42	R:R:L78	R:R:N396	13.8221	9.61	Yes	Yes	1	9	9
43	R:R:H126	R:R:W161	15.1359	4.23	Yes	Yes	1	8	9
44	R:R:D82	R:R:S393	11.0667	5.89	Yes	No	0	9	9
45	R:R:W102	R:R:Y96	60.9638	9.65	Yes	No	0	9	6
46	L:L:?1	R:R:Y96	64.2957	19.94	Yes	No	0	0	6
47	R:R:D183	R:R:D185	11.6516	2.66	No	No	0	1	4
48	R:R:A186	R:R:D183	16.2562	4.63	No	No	0	4	1
49	R:R:A186	R:R:T188	18.5461	1.68	No	No	0	4	5
50	R:R:K191	R:R:T188	20.7249	1.5	No	No	0	5	5
51	R:R:K191	R:R:P369	22.9984	3.35	No	No	0	5	7
52	R:R:P369	R:R:T196	25.2636	10.49	No	No	0	7	7
53	R:R:T196	R:R:T200	27.5206	3.14	No	Yes	0	7	7
54	R:R:F362	R:R:T200	26.5074	3.89	Yes	Yes	0	7	7
55	R:R:C109	R:R:W102	21.7422	5.22	No	Yes	1	9	9
56	R:R:C187	R:R:W102	21.7422	13.06	No	Yes	1	9	9
57	R:R:D110	R:R:M172	21.7916	4.16	No	No	0	7	6
58	R:R:I113	R:R:M172	29.0404	4.37	No	No	0	7	6
59	R:R:C109	R:R:I113	18.1384	3.27	No	No	1	9	7
60	R:R:C187	R:R:I113	18.1384	3.27	No	No	1	9	7
61	R:R:D110	R:R:Q106	14.5346	5.22	No	No	0	7	4
62	L:L:?1	R:R:V117	14.4028	8.45	Yes	No	0	0	8
63	R:R:S168	R:R:V117	10.9432	6.46	No	No	0	8	8
64	L:L:?1	R:R:T121	25.346	3.71	Yes	Yes	0	0	8
65	R:R:I167	R:R:T121	14.5758	7.6	No	Yes	0	8	8
66	R:R:C128	R:R:L210	11.4786	6.35	No	No	0	7	7
67	R:R:L210	R:R:L214	13.3979	5.54	No	No	0	7	7
68	R:R:L214	R:R:Y135	17.1705	5.86	No	Yes	0	7	9
69	R:R:I218	R:R:Y135	32.1376	3.63	No	Yes	0	9	9
70	R:R:I218	R:R:Y215	35.7867	4.84	No	Yes	0	9	9
71	R:R:D143	R:R:R152	27.7595	13.1	No	No	0	6	7
72	R:R:R148	R:R:R152	31.6928	7.46	Yes	No	0	8	7
73	R:R:D143	R:R:K147	15.9102	6.91	No	No	0	6	5
74	R:R:K147	R:R:N146	11.944	5.6	No	No	0	5	5
75	R:R:S199	R:R:Y195	25.4242	10.17	No	Yes	0	8	8
76	L:L:?1	R:R:S199	28.8962	3.78	Yes	No	0	0	8
77	R:R:F204	R:R:Y205	15.1606	9.28	Yes	Yes	0	8	7
78	R:R:F219	R:R:L347	30.2801	3.65	Yes	No	0	6	8
79	R:R:L347	R:R:Y215	32.117	3.52	No	Yes	0	8	9
80	R:R:F219	R:R:R223	19.0857	6.41	Yes	No	0	6	7
81	R:R:R223	R:R:R227	17.1911	10.66	No	No	0	7	6
82	R:R:E340	R:R:I226	13.5914	5.47	No	No	0	8	6
83	R:R:E340	R:R:R227	15.2842	9.3	No	No	0	8	6
84	R:R:I399	R:R:Y400	13.7521	9.67	No	Yes	0	8	9
85	R:R:F361	R:R:I385	15.7619	3.77	Yes	No	0	8	6
86	R:R:G382	R:R:M377	11.9316	1.75	No	Yes	0	4	4
87	R:R:G382	R:R:I385	13.2166	1.76	No	No	0	4	6
88	L:L:?1	R:R:Y390	18.0272	11.82	Yes	Yes	1	0	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L43	R:R:W387	12.53	0	No	Yes	7	8	2	1
R:R:D116	R:R:V89	10.22	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	7.03	0	No	Yes	8	8	2	1
R:R:A93	R:R:Y390	5.34	0	No	Yes	7	8	2	1
R:R:W102	R:R:Y96	9.65	1	Yes	No	9	6	2	1
L:L:?1	R:R:Y96	19.94	1	Yes	No	0	6	0	1
R:R:A383	R:R:Q97	4.55	0	No	No	6	7	2	1
R:R:Q97	R:R:W387	10.95	1	No	Yes	7	8	1	1
L:L:?1	R:R:Q97	10.9	1	Yes	No	0	7	0	1
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	11.49	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:D116	10.26	1	Yes	Yes	0	8	0	1
R:R:S168	R:R:V117	6.46	0	No	No	8	8	2	1
L:L:?1	R:R:V117	8.45	1	Yes	No	0	8	0	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	2
L:L:?1	R:R:C120	6	1	Yes	No	0	7	0	1
R:R:G164	R:R:T121	3.64	0	No	Yes	8	8	2	1
R:R:I167	R:R:T121	7.6	0	No	Yes	8	8	2	1
R:R:A203	R:R:T121	5.03	0	No	Yes	8	8	2	1
L:L:?1	R:R:T121	3.71	1	Yes	Yes	0	8	0	1
R:R:S199	R:R:Y195	10.17	0	No	Yes	8	8	1	2
L:L:?1	R:R:S199	3.78	1	Yes	No	0	8	0	1
R:R:F362	R:R:T200	3.89	1	Yes	Yes	7	7	1	2
R:R:F204	R:R:F362	22.51	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	6.01	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	9.02	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	9.65	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:I385	3.77	1	Yes	No	8	6	1	2
R:R:F361	R:R:N386	4.83	1	Yes	No	8	7	1	1
L:L:?1	R:R:F361	14.58	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	8.44	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	7.79	1	Yes	No	0	7	0	1
R:R:W387	R:R:Y390	8.68	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:W387	4.31	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y390	11.82	1	Yes	Yes	0	8	0	1
R:R:L46	R:R:W387	2.28	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9HYI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	268
Number of Links	290
Number of Hubs	33
Number of Links mediated by Hubs	135
Number of Communities	4
Number of Nodes involved in Communities	39
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	76512
Length Of Smallest Path	3
Average Path Length	12.9273
Length of Longest Path	27
Minimum Path Strength	1.365
Average Path Strength	6.54103
Maximum Path Strength	17.325
Minimum Path Correlation	0.7
Average Path Correlation	0.933015
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	51.4114
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.7652
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • signaling receptor binding • receptor-receptor interaction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • behavior • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • serotonin receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9HYI_nogp_Chain_R T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W S D P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

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Download 9HYI_nogp.zip

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