psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A93	5.15	Yes	No	1	0	7
2	L:L:?1	R:R:Y96	7.66	Yes	Yes	1	0	6
3	L:L:?1	R:R:W102	3.72	Yes	Yes	1	0	9
4	L:L:?1	R:R:F112	3.98	Yes	Yes	1	0	6
5	L:L:?1	R:R:D116	23.07	Yes	Yes	1	0	8
6	L:L:?1	R:R:V117	12.66	Yes	No	0	0	8
7	L:L:?1	R:R:C120	4.15	Yes	No	1	0	7
8	L:L:?1	R:R:S199	3.93	Yes	No	0	0	8
9	L:L:?1	R:R:F361	15.13	Yes	Yes	1	0	8
10	L:L:?1	R:R:F362	6.37	Yes	Yes	1	0	7
11	L:L:?1	R:R:N386	8.08	Yes	No	1	0	7
12	L:L:?1	R:R:Y390	9.2	Yes	Yes	1	0	8
13	R:R:T39	R:R:Y35	4.99	No	No	0	5	4
14	R:R:S40	R:R:V98	6.46	No	No	0	5	6
15	R:R:A94	R:R:L43	4.73	No	No	0	7	7
16	R:R:L43	R:R:W387	17.08	No	No	0	7	8
17	R:R:L394	R:R:L46	5.54	No	No	0	7	7
18	R:R:I47	R:R:L90	8.56	No	Yes	0	7	8
19	R:R:F48	R:R:L52	3.65	No	No	0	4	4
20	R:R:A50	R:R:L394	4.73	No	No	0	8	7
21	R:R:L83	R:R:V51	4.47	No	No	0	8	7
22	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
23	R:R:D82	R:R:N54	8.08	Yes	No	0	9	9
24	R:R:N54	R:R:P397	9.77	No	No	0	9	9
25	R:R:C56	R:R:Y402	4.03	No	Yes	0	8	6
26	R:R:A401	R:R:V57	5.09	No	Yes	2	8	9
27	R:R:V57	R:R:Y402	5.05	Yes	Yes	0	9	6
28	R:R:F407	R:R:V57	3.93	Yes	Yes	2	8	9
29	R:R:V58	R:R:V80	4.81	No	No	0	7	7
30	R:R:A60	R:R:F411	5.55	No	No	0	8	8
31	R:R:I61	R:R:N72	4.25	No	Yes	2	8	9
32	R:R:F407	R:R:I61	6.28	Yes	No	2	8	8
33	R:R:E64	R:R:L67	3.98	Yes	Yes	0	7	8
34	R:R:A410	R:R:E64	4.53	No	Yes	0	8	7
35	R:R:E64	R:R:K413	14.85	Yes	No	0	7	6
36	R:R:Q68	R:R:R65	9.35	No	No	0	8	7
37	R:R:L67	R:R:N72	4.12	Yes	Yes	2	8	9
38	R:R:D406	R:R:L67	5.43	Yes	Yes	2	7	8
39	R:R:F407	R:R:L67	8.53	Yes	Yes	2	8	8
40	R:R:Q68	R:R:Y73	6.76	No	No	0	8	6
41	R:R:N69	R:R:N72	9.54	No	Yes	0	8	9
42	R:R:R148	R:R:V70	17	Yes	No	0	8	7
43	R:R:P150	R:R:V70	5.3	No	No	0	5	7
44	R:R:D406	R:R:N72	6.73	Yes	Yes	2	7	9
45	R:R:F407	R:R:N72	4.83	Yes	Yes	2	8	9
46	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
47	R:R:D133	R:R:L74	5.43	No	No	0	9	8
48	R:R:L156	R:R:L74	4.15	No	No	0	6	8
49	R:R:I75	R:R:Y400	4.84	No	Yes	0	8	9
50	R:R:H126	R:R:S77	8.37	Yes	No	1	8	9
51	R:R:I157	R:R:S77	12.39	No	No	1	8	9
52	R:R:D82	R:R:L78	5.43	Yes	Yes	1	9	9
53	R:R:H126	R:R:L78	6.43	Yes	Yes	1	8	9
54	R:R:L127	R:R:L78	5.54	Yes	Yes	1	8	9
55	R:R:I130	R:R:L78	4.28	No	Yes	1	9	9
56	R:R:L78	R:R:N396	12.36	Yes	Yes	1	9	9
57	R:R:L78	R:R:Y400	4.69	Yes	Yes	1	9	9
58	R:R:H126	R:R:T81	12.32	Yes	No	1	8	9
59	R:R:T81	R:R:W161	9.7	No	Yes	1	9	9
60	R:R:D82	R:R:S123	7.36	Yes	No	0	9	9
61	R:R:D82	R:R:S393	5.89	Yes	No	0	9	9
62	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
63	R:R:M84	R:R:W161	5.82	No	Yes	0	7	9
64	R:R:L90	R:R:V85	4.47	Yes	No	0	8	8
65	R:R:S393	R:R:V85	6.46	No	No	0	9	8
66	R:R:L115	R:R:L88	8.3	No	No	0	5	6
67	R:R:D116	R:R:V89	11.69	Yes	No	1	8	8
68	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
69	R:R:L90	R:R:Y390	8.21	Yes	Yes	0	8	8
70	R:R:F112	R:R:M92	14.93	Yes	No	0	6	6
71	R:R:A93	R:R:Y390	4	No	Yes	1	7	8
72	R:R:L95	R:R:L99	5.54	No	No	0	6	5
73	R:R:W102	R:R:Y96	9.65	Yes	Yes	1	9	6
74	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
75	R:R:Q97	R:R:W387	5.48	No	No	0	7	8
76	R:R:D185	R:R:K101	12.44	No	No	0	4	5
77	R:R:L104	R:R:W102	13.67	No	Yes	1	7	9
78	R:R:T108	R:R:W102	4.85	Yes	Yes	1	6	9
79	R:R:C109	R:R:W102	9.14	No	Yes	1	9	9
80	R:R:F112	R:R:W102	4.01	Yes	Yes	1	6	9
81	R:R:C187	R:R:W102	13.06	No	Yes	1	9	9
82	R:R:L104	R:R:T108	4.42	No	Yes	1	7	6
83	R:R:F112	R:R:T108	6.49	Yes	Yes	1	6	6
84	R:R:C109	R:R:C187	7.28	No	No	1	9	9
85	R:R:D110	R:R:M172	4.16	No	No	0	7	6
86	R:R:D110	R:R:R176	13.1	No	No	0	7	6
87	R:R:F112	R:R:L111	7.31	Yes	No	0	6	5
88	R:R:A114	R:R:M172	4.83	No	No	0	7	6
89	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
90	R:R:D116	R:R:Y390	11.49	Yes	Yes	1	8	8
91	R:R:S168	R:R:V117	6.46	No	No	0	8	8
92	R:R:V117	R:R:Y195	3.79	No	Yes	0	8	8
93	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
94	R:R:F165	R:R:L118	14.61	No	No	0	5	6
95	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
96	R:R:G164	R:R:T121	3.64	No	No	0	8	8
97	R:R:I167	R:R:T121	6.08	No	No	0	8	8
98	R:R:A203	R:R:T121	5.03	No	No	0	8	8
99	R:R:S122	R:R:W161	16.06	No	Yes	0	8	9
100	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
101	R:R:I124	R:R:W358	11.74	No	Yes	1	8	8
102	R:R:I163	R:R:W125	19.97	No	Yes	0	5	7
103	R:R:P207	R:R:W125	17.57	No	Yes	0	9	7
104	R:R:H126	R:R:I157	5.3	Yes	No	1	8	8
105	R:R:H126	R:R:T160	13.69	Yes	No	0	8	8
106	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
107	R:R:F354	R:R:L127	4.87	Yes	Yes	1	9	8
108	R:R:L127	R:R:N396	12.36	Yes	Yes	1	8	9
109	R:R:L127	R:R:Y400	7.03	Yes	Yes	1	8	9
110	R:R:C128	R:R:P207	3.77	No	No	0	7	9
111	R:R:C128	R:R:M211	4.86	No	No	0	7	9
112	R:R:A129	R:R:L156	6.3	No	No	0	8	6
113	R:R:I130	R:R:R134	6.26	No	Yes	1	9	9
114	R:R:I130	R:R:Y400	9.67	No	Yes	1	9	9
115	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
116	R:R:L132	R:R:W136	15.94	No	No	0	6	5
117	R:R:L132	R:R:L214	5.54	No	No	0	6	7
118	R:R:D133	R:R:R148	9.53	No	Yes	0	9	8
119	R:R:R134	R:R:Y215	8.23	Yes	Yes	1	9	9
120	R:R:I350	R:R:R134	3.76	Yes	Yes	1	8	9
121	R:R:R134	R:R:Y400	6.17	Yes	Yes	1	9	9
122	R:R:W136	R:R:Y135	3.86	No	Yes	0	5	9
123	R:R:T139	R:R:Y135	13.73	No	Yes	0	8	9
124	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
125	R:R:R217	R:R:Y135	19.55	No	Yes	0	7	9
126	R:R:I218	R:R:Y135	4.84	No	Yes	0	9	9
127	R:R:R152	R:R:W136	4	No	No	0	7	5
128	R:R:A137	R:R:Y144	4	No	No	0	8	8
129	R:R:D140	R:R:D143	6.65	No	No	0	7	6
130	R:R:D143	R:R:K147	4.15	No	No	0	6	5
131	R:R:D143	R:R:R152	11.91	No	No	0	6	7
132	R:R:R148	R:R:Y144	16.46	Yes	No	0	8	8
133	R:R:N146	R:R:V145	4.43	No	No	0	5	6
134	R:R:R148	R:R:R152	4.26	Yes	No	0	8	7
135	R:R:L162	R:R:L166	4.15	No	No	0	5	5
136	R:R:F165	R:R:I169	3.77	No	No	0	5	6
137	R:R:I167	R:R:Y198	6.04	No	No	0	8	5
138	R:R:I169	R:R:L173	4.28	No	No	0	6	6
139	R:R:P170	R:R:P171	5.84	No	No	0	8	7
140	R:R:P170	R:R:W175	5.4	No	No	5	8	6
141	R:R:P170	R:R:Y198	4.17	No	No	5	8	5
142	R:R:P171	R:R:Y195	13.91	No	Yes	0	7	8
143	R:R:W175	R:R:Y198	4.82	No	No	5	6	5
144	R:R:I189	R:R:K191	4.36	No	No	0	6	5
145	R:R:I189	R:R:Y195	6.04	No	Yes	0	6	8
146	R:R:S190	R:R:Y195	8.9	No	Yes	0	6	8
147	R:R:F370	R:R:H193	16.97	No	No	0	5	4
148	R:R:S199	R:R:Y195	12.72	No	Yes	0	8	8
149	R:R:P369	R:R:T196	12.24	No	No	0	7	7
150	R:R:F370	R:R:T196	3.89	No	No	0	5	7
151	R:R:F370	R:R:I197	5.02	No	No	0	5	7
152	R:R:T200	R:R:Y205	4.99	No	Yes	1	7	7
153	R:R:F362	R:R:T200	3.89	Yes	No	1	7	7
154	R:R:L366	R:R:T200	5.9	No	No	1	7	7
155	R:R:F201	R:R:Y205	12.38	No	Yes	1	5	7
156	R:R:F201	R:R:L366	3.65	No	No	1	5	7
157	R:R:F204	R:R:Y205	9.28	Yes	Yes	1	8	7
158	R:R:F204	R:R:L208	10.96	Yes	No	1	8	7
159	R:R:F204	R:R:F354	8.57	Yes	Yes	1	8	9
160	R:R:F204	R:R:W358	5.01	Yes	Yes	1	8	8
161	R:R:F204	R:R:L359	7.31	Yes	Yes	0	8	7
162	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
163	R:R:L366	R:R:Y205	5.86	No	Yes	1	7	7
164	R:R:L208	R:R:L212	5.54	No	No	0	7	6
165	R:R:F354	R:R:L208	3.65	Yes	No	1	9	7
166	R:R:M211	R:R:M351	4.33	No	No	0	9	8
167	R:R:F354	R:R:M211	9.95	Yes	No	0	9	9
168	R:R:L212	R:R:M351	4.24	No	No	0	6	8
169	R:R:R217	R:R:V213	5.23	No	No	0	7	5
170	R:R:I218	R:R:Y215	3.63	No	Yes	0	9	9
171	R:R:L347	R:R:Y215	5.86	No	Yes	0	8	9
172	R:R:I350	R:R:Y215	8.46	Yes	Yes	1	8	9
173	R:R:M351	R:R:Y215	4.79	No	Yes	0	8	9
174	R:R:R217	R:R:R220	9.6	No	No	0	7	5
175	R:R:F219	R:R:R223	16.03	Yes	Yes	3	6	7
176	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
177	R:R:R223	R:R:R227	11.73	Yes	No	3	7	6
178	R:R:E340	R:R:R223	22.1	Yes	Yes	3	8	7
179	R:R:F224	R:R:R225	7.48	No	No	6	6	7
180	R:R:F224	R:R:K228	8.69	No	No	6	6	5
181	R:R:K228	R:R:R225	9.9	No	No	6	5	7
182	R:R:I226	R:R:R339	5.01	No	No	0	6	7
183	R:R:E340	R:R:I226	6.83	Yes	No	0	8	6
184	R:R:E340	R:R:R227	13.96	Yes	No	3	8	6
185	R:R:K324	R:R:R323	3.71	No	No	0	1	2
186	R:R:E326	R:R:N325	6.57	No	No	0	3	5
187	R:R:E330	R:R:R333	12.79	No	No	0	4	4
188	R:R:L337	R:R:R333	3.64	No	No	0	5	4
189	R:R:M335	R:R:R339	8.69	No	No	0	4	7
190	R:R:E340	R:R:L337	3.98	Yes	No	0	8	5
191	R:R:I349	R:R:I399	4.42	No	No	0	7	8
192	R:R:I350	R:R:Y400	3.63	Yes	Yes	1	8	9
193	R:R:I399	R:R:T353	6.08	No	No	0	8	7
194	R:R:F354	R:R:W358	5.01	Yes	Yes	1	9	8
195	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
196	R:R:C357	R:R:N392	7.87	No	No	0	8	9
197	R:R:F361	R:R:W358	7.02	Yes	Yes	1	8	8
198	R:R:F362	R:R:W358	9.02	Yes	Yes	1	7	8
199	R:R:G389	R:R:W358	11.26	No	Yes	0	8	8
200	R:R:N392	R:R:W358	7.91	No	Yes	0	9	8
201	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
202	R:R:F361	R:R:F362	15	Yes	Yes	1	8	7
203	R:R:F361	R:R:N386	6.04	Yes	No	1	8	7
204	R:R:L368	R:R:V364	4.47	No	No	4	4	6
205	R:R:M377	R:R:V364	6.09	Yes	No	4	4	6
206	R:R:L368	R:R:M377	5.65	No	Yes	4	4	4
207	R:R:C371	R:R:C375	7.28	No	No	0	5	4
208	R:R:M377	R:R:P378	5.03	Yes	No	4	4	7
209	R:R:L381	R:R:M377	4.24	No	Yes	4	6	4
210	R:R:L381	R:R:P378	4.93	No	No	4	6	7
211	R:R:I384	R:R:L380	4.28	No	No	0	4	3
212	R:R:I385	R:R:L381	4.28	No	No	0	6	6
213	R:R:W387	R:R:Y390	16.4	No	Yes	0	8	8
214	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
215	R:R:V398	R:R:Y402	3.79	No	Yes	0	6	6
216	R:R:F403	R:R:V398	3.93	No	No	0	8	6
217	R:R:I399	R:R:Y400	6.04	No	Yes	0	8	9
218	R:R:A401	R:R:F407	9.71	No	Yes	2	8	8
219	R:R:F411	R:R:Y402	10.32	No	Yes	0	8	6
220	R:R:D406	R:R:N404	14.81	Yes	No	2	7	9
221	R:R:F407	R:R:N404	7.25	Yes	No	2	8	9
222	R:R:D406	R:R:F407	4.78	Yes	Yes	2	7	8
223	R:R:F407	R:R:F411	6.43	Yes	No	0	8	8
224	R:R:I206	R:R:W125	3.52	No	Yes	0	6	7
225	R:R:P150	R:R:T149	3.5	No	No	0	5	8
226	R:R:G382	R:R:M377	3.49	No	Yes	0	4	4
227	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
228	R:R:C371	R:R:S374	3.44	No	No	0	5	5
229	R:R:A50	R:R:S86	3.42	No	No	0	8	8
230	R:R:C119	R:R:V85	3.42	No	No	0	7	8
231	R:R:C119	R:R:V89	3.42	No	No	0	7	8
232	R:R:I47	R:R:P91	3.39	No	No	0	7	9
233	R:R:A79	R:R:V57	3.39	Yes	Yes	0	9	9
234	R:R:A153	R:R:V70	3.39	No	No	0	7	7
235	R:R:I385	R:R:P360	3.39	No	No	0	6	9
236	R:R:K191	R:R:P369	3.35	No	No	0	5	7
237	R:R:D192	R:R:G194	3.35	No	No	0	6	5
238	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
239	R:R:L388	R:R:P360	3.28	No	No	0	8	9
240	R:R:C187	R:R:I113	3.27	No	No	0	9	7
241	R:R:S86	R:R:V51	3.23	No	No	0	8	7
242	R:R:D140	R:R:P141	3.22	No	No	0	7	8
243	R:R:V51	R:R:V87	3.21	No	No	0	7	6
244	R:R:T39	R:R:V98	3.17	No	No	0	5	6
245	R:R:C49	R:R:L394	3.17	No	No	0	5	7
246	R:R:C56	R:R:L52	3.17	No	No	0	8	4
247	R:R:C119	R:R:L115	3.17	No	No	0	7	5
248	R:R:A55	R:R:L83	3.15	No	No	0	5	8
249	R:R:A79	R:R:N54	3.13	Yes	No	0	9	9
250	R:R:L67	R:R:S66	3	Yes	No	0	8	6
251	R:R:L90	R:R:S86	3	Yes	No	0	8	8
252	R:R:L43	R:R:T39	2.95	No	No	0	7	5
253	R:R:L99	R:R:T103	2.95	No	No	0	5	5
254	R:R:L104	R:R:T103	2.95	No	No	0	7	5
255	R:R:L395	R:R:T353	2.95	No	No	0	6	7
256	R:R:I138	R:R:I218	2.94	No	No	0	9	9
257	R:R:I349	R:R:K345	2.91	No	No	0	7	7
258	R:R:Q36	R:R:V98	2.87	No	No	0	4	6
259	R:R:I38	R:R:L42	2.85	No	No	0	3	5
260	R:R:I414	R:R:L63	2.85	No	No	0	7	6
261	R:R:I142	R:R:N146	2.83	No	No	0	6	5
262	R:R:K101	R:R:L99	2.82	No	No	0	5	5
263	R:R:D140	R:R:I142	2.8	No	No	0	7	6
264	R:R:K412	R:R:N409	2.8	No	No	0	6	6
265	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
266	R:R:E64	R:R:I414	2.73	Yes	No	0	7	7
267	R:R:R176	R:R:S190	2.64	No	No	0	6	6
268	R:R:F219	R:R:V344	2.62	Yes	No	3	6	8
269	R:R:R223	R:R:V344	2.62	Yes	No	3	7	8
270	R:R:F219	R:R:T343	2.59	Yes	No	3	6	8
271	R:R:R223	R:R:T343	2.59	Yes	No	3	7	8
272	R:R:L337	R:R:R341	2.43	No	No	0	5	6
273	R:R:L210	R:R:W125	2.28	No	Yes	0	7	7
274	R:R:R323	R:R:R327	2.13	No	No	0	2	3
275	R:R:A79	R:R:G76	1.95	Yes	No	0	9	6
276	R:R:G105	R:R:T108	1.82	No	Yes	0	7	6
277	R:R:G202	R:R:I167	1.76	No	No	0	5	8
278	R:R:G202	R:R:I206	1.76	No	No	0	5	6
279	R:R:C357	R:R:S391	1.72	No	No	0	8	5
280	R:R:A79	R:R:V58	1.7	Yes	No	0	9	7
281	R:R:A221	R:R:T139	1.68	No	No	0	6	8
282	R:R:A222	R:R:T343	1.68	No	No	0	8	8
283	R:R:S34	R:R:V37	1.62	No	No	0	3	5
284	R:R:A336	R:R:I226	1.62	No	No	0	5	6
285	R:R:C375	R:R:L368	1.59	No	No	0	4	4
286	R:R:A59	R:R:L63	1.58	No	No	0	5	6
287	R:R:I38	R:R:V37	1.54	No	No	0	3	5
288	R:R:A71	R:R:D133	1.54	No	No	0	8	9
289	R:R:I363	R:R:V367	1.54	No	No	0	7	6
290	R:R:I350	R:R:T346	1.52	Yes	No	0	8	8
291	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
292	R:R:K342	R:R:T346	1.5	No	No	0	8	8
293	R:R:L209	R:R:V213	1.49	No	No	0	5	5
294	R:R:I163	R:R:L159	1.43	No	No	0	5	3
295	R:R:K405	R:R:N404	1.4	No	No	0	6	9
296	R:R:L159	R:R:L162	1.38	No	No	0	3	5
297	R:R:A338	R:R:R341	1.38	No	No	0	5	6
298	R:R:L356	R:R:L388	1.38	No	No	0	5	8
299	R:R:K412	R:R:Q408	1.36	No	No	0	6	9
300	R:R:E330	R:R:K334	1.35	No	No	0	4	5
301	R:R:A186	R:R:Y96	1.33	No	Yes	0	4	6
302	R:R:D110	R:R:Q106	1.31	No	No	0	7	4
303	R:R:R151	R:R:T149	1.29	No	No	0	6	8
304	R:R:T188	R:R:Y96	1.25	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.59167	12	1	0
2	R:R:V57	4.365	4	2	9
3	R:R:E64	6.5225	4	0	7
4	R:R:L67	5.012	5	2	8
5	R:R:N72	5.894	5	2	9
6	R:R:L78	6.455	6	1	9
7	R:R:A79	2.5425	4	0	9
8	R:R:D82	6.968	5	1	9
9	R:R:L90	6.06	4	0	8
10	R:R:Y96	4.9725	4	1	6
11	R:R:W102	8.3	7	1	9
12	R:R:T108	4.395	4	1	6
13	R:R:F112	7.344	5	1	6
14	R:R:D116	12.73	4	1	8
15	R:R:W125	10.835	4	0	7
16	R:R:H126	8.56667	6	1	8
17	R:R:L127	7.45	4	1	8
18	R:R:R134	6.105	4	1	9
19	R:R:Y135	9.568	5	0	9
20	R:R:R148	11.8125	4	0	8
21	R:R:W161	8.74	5	1	9
22	R:R:Y195	8.135	6	0	8
23	R:R:F204	10.2483	6	1	8
24	R:R:Y205	8.1275	4	1	7
25	R:R:Y215	6.27333	6	1	9
26	R:R:F219	5.28	5	3	6
27	R:R:R223	11.014	5	3	7
28	R:R:E340	11.7175	4	3	8
29	R:R:I350	4.3425	4	1	8
30	R:R:F354	6.17833	6	1	9
31	R:R:W358	7.77375	8	1	8
32	R:R:L359	5.5025	4	0	7
33	R:R:F361	9.192	5	1	8
34	R:R:F362	10.928	5	1	7
35	R:R:M377	4.9	5	4	4
36	R:R:Y390	8.84833	6	1	8
37	R:R:N396	11.265	4	1	9
38	R:R:Y400	6.01	7	1	9
39	R:R:Y402	5.508	5	0	6
40	R:R:D406	7.9375	4	2	7
41	R:R:F407	6.4675	8	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	39.7702	9.2	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	25.5857	16.4	No	Yes	0	8	8
3	R:R:L43	R:R:W387	18.1281	17.08	No	No	0	7	8
4	R:R:L43	R:R:T39	13.0847	2.95	No	No	0	7	5
5	R:R:L90	R:R:Y390	21.7326	8.21	Yes	Yes	0	8	8
6	R:R:L90	R:R:S86	15.5217	3	Yes	No	0	8	8
7	L:L:?1	R:R:C120	40.2524	4.15	Yes	No	1	0	7
8	R:R:C120	R:R:W358	46.6215	5.22	No	Yes	1	7	8
9	R:R:N392	R:R:W358	46.9303	7.91	No	Yes	0	9	8
10	R:R:N392	R:R:N396	46.4331	12.26	No	Yes	0	9	9
11	R:R:D82	R:R:N396	37.2919	8.08	Yes	Yes	1	9	9
12	R:R:D82	R:R:N54	78.4972	8.08	Yes	No	0	9	9
13	R:R:A79	R:R:N54	74.1205	3.13	Yes	No	0	9	9
14	R:R:A79	R:R:V57	65.2768	3.39	Yes	Yes	0	9	9
15	R:R:V57	R:R:Y402	21.435	5.05	Yes	Yes	0	9	6
16	L:L:?1	R:R:F361	40.7119	15.13	Yes	Yes	1	0	8
17	R:R:F361	R:R:W358	41.9925	7.02	Yes	Yes	1	8	8
18	L:L:?1	R:R:F362	92.6328	6.37	Yes	Yes	1	0	7
19	R:R:F362	R:R:W358	41.3371	9.02	Yes	Yes	1	7	8
20	R:R:L90	R:R:V85	23.6008	4.47	Yes	No	0	8	8
21	R:R:S393	R:R:V85	27.0772	6.46	No	No	0	9	8
22	R:R:D82	R:R:S393	27.9774	5.89	Yes	No	0	9	9
23	R:R:F407	R:R:V57	40.0904	3.93	Yes	Yes	2	8	9
24	R:R:F407	R:R:L67	19.3107	8.53	Yes	Yes	2	8	8
25	R:R:E64	R:R:L67	14.6629	3.98	Yes	Yes	0	7	8
26	R:R:F354	R:R:W358	85.0433	5.01	Yes	Yes	1	9	8
27	R:R:F354	R:R:M211	92.6252	9.95	Yes	No	0	9	9
28	R:R:M211	R:R:M351	79.7024	4.33	No	No	0	9	8
29	R:R:M351	R:R:Y215	100	4.79	No	Yes	0	8	9
30	R:R:I218	R:R:Y215	99.4011	3.63	No	Yes	0	9	9
31	R:R:I218	R:R:Y135	94.2787	4.84	No	Yes	0	9	9
32	R:R:W136	R:R:Y135	70.7533	3.86	No	Yes	0	5	9
33	R:R:R152	R:R:W136	65.5631	4	No	No	0	7	5
34	R:R:R148	R:R:R152	44.3503	4.26	Yes	No	0	8	7
35	R:R:R148	R:R:V70	22.4143	17	Yes	No	0	8	7
36	R:R:P150	R:R:V70	16.855	5.3	No	No	0	5	7
37	R:R:F204	R:R:F362	51.8456	20.36	Yes	Yes	1	8	7
38	R:R:F204	R:R:F354	40.6591	8.57	Yes	Yes	1	8	9
39	R:R:F204	R:R:L208	22.3465	10.96	Yes	No	1	8	7
40	R:R:L208	R:R:L212	22.4896	5.54	No	No	0	7	6
41	R:R:L212	R:R:M351	21.8832	4.24	No	No	0	6	8
42	R:R:D133	R:R:R148	14.064	9.53	No	Yes	0	9	8
43	R:R:F354	R:R:L127	45.5066	4.87	Yes	Yes	1	9	8
44	R:R:L127	R:R:Y400	18.4783	7.03	Yes	Yes	1	8	9
45	R:R:L127	R:R:L78	22.3691	5.54	Yes	Yes	1	8	9
46	R:R:H126	R:R:L78	34.8701	6.43	Yes	Yes	1	8	9
47	R:R:L78	R:R:N396	13.6083	12.36	Yes	Yes	1	9	9
48	R:R:I130	R:R:L78	18.0377	4.28	No	Yes	1	9	9
49	L:L:?1	R:R:F112	14.5574	3.98	Yes	Yes	1	0	6
50	L:L:?1	R:R:W102	35.0019	3.72	Yes	Yes	1	0	9
51	R:R:L104	R:R:W102	17.7815	13.67	No	Yes	1	7	9
52	R:R:L104	R:R:T103	14.9303	2.95	No	No	0	7	5
53	R:R:L99	R:R:T103	11.9586	2.95	No	No	0	5	5
54	L:L:?1	R:R:V117	58.4068	12.66	Yes	No	0	0	8
55	R:R:V117	R:R:Y195	53.258	3.79	No	Yes	0	8	8
56	R:R:S190	R:R:Y195	32.8211	8.9	No	Yes	0	6	8
57	R:R:R176	R:R:S190	27.3484	2.64	No	No	0	6	6
58	R:R:D110	R:R:R176	21.8682	13.1	No	No	0	7	6
59	R:R:D110	R:R:M172	11.0094	4.16	No	No	0	7	6
60	L:L:?1	R:R:S199	55.8305	3.93	Yes	No	0	0	8
61	R:R:S199	R:R:Y195	53.2919	12.72	No	Yes	0	8	8
62	R:R:H126	R:R:W161	20.2825	5.29	Yes	Yes	1	8	9
63	R:R:L118	R:R:W161	11.8682	6.83	No	Yes	0	6	9
64	R:R:P171	R:R:Y195	21.6045	13.91	No	Yes	0	7	8
65	R:R:P170	R:R:P171	16.2486	5.84	No	No	0	8	7
66	R:R:C128	R:R:M211	19.5857	4.86	No	No	0	7	9
67	R:R:C128	R:R:P207	17.5405	3.77	No	No	0	7	9
68	R:R:P207	R:R:W125	15.5782	17.57	No	Yes	0	9	7
69	R:R:R134	R:R:Y400	19.7665	6.17	Yes	Yes	1	9	9
70	R:R:I350	R:R:Y400	23.0998	3.63	Yes	Yes	1	8	9
71	R:R:R217	R:R:Y135	11.2655	19.55	No	Yes	0	7	9
72	R:R:D143	R:R:R152	19.6347	11.91	No	No	0	6	7
73	R:R:D140	R:R:D143	14.064	6.65	No	No	0	7	6
74	R:R:I189	R:R:Y195	38.4105	6.04	No	Yes	0	6	8
75	R:R:I189	R:R:K191	32.9454	4.36	No	No	0	6	5
76	R:R:K191	R:R:P369	27.4727	3.35	No	No	0	5	7
77	R:R:P369	R:R:T196	21.9925	12.24	No	No	0	7	7
78	R:R:F370	R:R:T196	16.5047	3.89	No	No	0	5	7
79	R:R:F204	R:R:L359	26.1846	7.31	Yes	Yes	0	8	7
80	R:R:L347	R:R:Y215	52.1921	5.86	No	Yes	0	8	9
81	R:R:F219	R:R:L347	49.4991	3.65	Yes	No	0	6	8
82	R:R:F219	R:R:R223	35.774	16.03	Yes	Yes	3	6	7
83	R:R:E340	R:R:R223	30.3879	22.1	Yes	Yes	3	8	7
84	R:R:E340	R:R:I226	11.2505	6.83	Yes	No	0	8	6
85	R:R:E340	R:R:L337	16.855	3.98	Yes	No	0	8	5
86	R:R:I399	R:R:Y400	10.9755	6.04	No	Yes	0	8	9
87	R:R:L359	R:R:P360	20.2185	3.28	Yes	No	0	7	9
88	R:R:I385	R:R:P360	15.6648	3.39	No	No	0	6	9
89	R:R:I385	R:R:L381	14.1318	4.28	No	No	0	6	6
90	R:R:L381	R:R:M377	11.0169	4.24	No	Yes	4	6	4
91	R:R:D192	R:R:Y195	11.0094	3.45	No	Yes	0	6	8
92	R:R:D82	R:R:L78	47.4953	5.43	Yes	Yes	1	9	9
93	R:R:L78	R:R:Y400	34.3126	4.69	Yes	Yes	1	9	9
94	R:R:I130	R:R:R134	16.0791	6.26	No	Yes	1	9	9
95	R:R:R134	R:R:Y215	34.1883	8.23	Yes	Yes	1	9	9
96	R:R:I350	R:R:Y215	19.0207	8.46	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A93	5.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y96	7.66	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W102	3.72	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F112	3.98	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:D116	23.07	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V117	12.66	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	4.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:S199	3.93	1	Yes	No	0	8	0	1
L:L:?1	R:R:F361	15.13	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	6.37	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.08	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	9.2	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	11.69	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:Y390	8.21	0	Yes	Yes	8	8	2	1
R:R:F112	R:R:M92	14.93	1	Yes	No	6	6	1	2
R:R:A93	R:R:Y390	4	1	No	Yes	7	8	1	1
R:R:W102	R:R:Y96	9.65	1	Yes	Yes	9	6	1	1
R:R:L104	R:R:W102	13.67	1	No	Yes	7	9	2	1
R:R:T108	R:R:W102	4.85	1	Yes	Yes	6	9	2	1
R:R:C109	R:R:W102	9.14	1	No	Yes	9	9	2	1
R:R:F112	R:R:W102	4.01	1	Yes	Yes	6	9	1	1
R:R:C187	R:R:W102	13.06	1	No	Yes	9	9	2	1
R:R:L104	R:R:T108	4.42	1	No	Yes	7	6	2	2
R:R:F112	R:R:T108	6.49	1	Yes	Yes	6	6	1	2
R:R:C109	R:R:C187	7.28	1	No	No	9	9	2	2
R:R:F112	R:R:L111	7.31	1	Yes	No	6	5	1	2
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	11.49	1	Yes	Yes	8	8	1	1
R:R:S168	R:R:V117	6.46	0	No	No	8	8	2	1
R:R:V117	R:R:Y195	3.79	0	No	Yes	8	8	1	2
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	2
R:R:S199	R:R:Y195	12.72	0	No	Yes	8	8	1	2
R:R:F362	R:R:T200	3.89	1	Yes	No	7	7	1	2
R:R:F204	R:R:W358	5.01	1	Yes	Yes	8	8	2	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	7.02	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	9.02	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	15	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	6.04	1	Yes	No	8	7	1	1
R:R:W387	R:R:Y390	16.4	0	No	Yes	8	8	2	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1
R:R:A186	R:R:Y96	1.33	0	No	Yes	4	6	2	1
R:R:T188	R:R:Y96	1.25	0	No	Yes	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9VJF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	260
Number of Links	304
Number of Hubs	41
Number of Links mediated by Hubs	163
Number of Communities	6
Number of Nodes involved in Communities	64
Number of Links involved in Communities	100

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	86859
Length Of Smallest Path	3
Average Path Length	12.9785
Length of Longest Path	25
Minimum Path Strength	1.29
Average Path Strength	6.87496
Maximum Path Strength	19.065
Minimum Path Correlation	0.7
Average Path Correlation	0.942085
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	56.7131
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.1319
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • GDP binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular process • cell division • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of molecular function • regulation of adenylate cyclase activity
Gene Ontology	Biological Process	• cellular process • cell division • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of autophagy • catabolic process • macroautophagy • autophagy • positive regulation of biological process • regulation of catabolic process • regulation of autophagy • positive regulation of catabolic process • positive regulation of metabolic process • regulation of macroautophagy • metabolic process • positive regulation of macroautophagy • process utilizing autophagic mechanism • regulation of metabolic process • positive regulation of cellular process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • purine nucleoside triphosphate metabolic process • GTP metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • nucleoside triphosphate metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytoplasm • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • somatodendritic compartment • dendrite • dendritic tree • neuron projection • synapse • cell junction • periplasmic space • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YLX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YLX
Name	Buspirone
Synonyms	Buspironum
Identifier
Formula	C21 H31 N5 O2
Molecular Weight	385.503
SMILES
PubChem	2477
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9VJF_nogp_Chain_R S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K R K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9VJF_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.