psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D116	21.08	Yes	Yes	1	0	8
2	L:L:?1	R:R:V117	10.52	Yes	No	0	0	8
3	L:L:?1	R:R:C120	5.6	Yes	No	1	0	7
4	L:L:?1	R:R:I189	8.06	Yes	Yes	0	0	6
5	L:L:?1	R:R:S199	7.42	Yes	No	0	0	8
6	L:L:?1	R:R:W358	4.02	Yes	Yes	1	0	8
7	L:L:?1	R:R:F361	16.33	Yes	Yes	1	0	8
8	L:L:?1	R:R:F362	11.18	Yes	Yes	1	0	7
9	L:L:?1	R:R:N386	14.54	Yes	No	1	0	7
10	L:L:?1	R:R:Y390	10.76	Yes	Yes	1	0	8
11	R:R:Q36	R:R:V98	4.3	No	No	0	4	6
12	R:R:L43	R:R:W387	15.94	No	Yes	0	7	8
13	R:R:L46	R:R:S391	6.01	No	No	0	7	5
14	R:R:L394	R:R:L46	5.54	No	No	0	7	7
15	R:R:I47	R:R:L90	9.99	No	Yes	0	7	8
16	R:R:A50	R:R:L394	4.73	No	No	0	8	7
17	R:R:L83	R:R:V51	4.47	No	No	0	8	7
18	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
19	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
20	R:R:N54	R:R:P397	11.4	No	No	0	9	9
21	R:R:A401	R:R:V57	5.09	No	No	0	8	9
22	R:R:V57	R:R:Y402	5.05	No	Yes	0	9	6
23	R:R:V58	R:R:V80	6.41	No	No	0	7	7
24	R:R:A60	R:R:F411	5.55	No	Yes	0	8	8
25	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
26	R:R:E64	R:R:L63	3.98	Yes	No	0	7	6
27	R:R:E64	R:R:L67	5.3	Yes	Yes	2	7	8
28	R:R:A410	R:R:E64	4.53	No	Yes	2	8	7
29	R:R:E64	R:R:K413	9.45	Yes	No	0	7	6
30	R:R:E64	R:R:I414	5.47	Yes	No	0	7	7
31	R:R:L67	R:R:N72	4.12	Yes	No	2	8	9
32	R:R:D406	R:R:L67	5.43	No	Yes	0	7	8
33	R:R:F407	R:R:L67	9.74	Yes	Yes	2	8	8
34	R:R:A410	R:R:L67	4.73	No	Yes	2	8	8
35	R:R:Q68	R:R:Y73	10.15	No	No	0	8	6
36	R:R:N69	R:R:N72	10.9	No	No	0	8	9
37	R:R:D133	R:R:V70	4.38	Yes	Yes	3	9	7
38	R:R:R148	R:R:V70	17	Yes	Yes	3	8	7
39	R:R:F407	R:R:N72	6.04	Yes	No	2	8	9
40	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
41	R:R:D133	R:R:L74	5.43	Yes	No	0	9	8
42	R:R:L156	R:R:L74	5.54	No	No	0	6	8
43	R:R:I75	R:R:Y400	4.84	No	Yes	0	8	9
44	R:R:H126	R:R:S77	6.97	Yes	No	1	8	9
45	R:R:I157	R:R:S77	12.39	No	No	1	8	9
46	R:R:D82	R:R:L78	8.14	Yes	Yes	1	9	9
47	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
48	R:R:L127	R:R:L78	4.15	Yes	Yes	1	8	9
49	R:R:I130	R:R:L78	4.28	No	Yes	1	9	9
50	R:R:L78	R:R:N396	13.73	Yes	Yes	1	9	9
51	R:R:L78	R:R:Y400	4.69	Yes	Yes	1	9	9
52	R:R:S122	R:R:T81	7.99	No	No	1	8	9
53	R:R:H126	R:R:T81	10.95	Yes	No	1	8	9
54	R:R:T81	R:R:W161	8.49	No	Yes	1	9	9
55	R:R:D82	R:R:S123	4.42	Yes	No	0	9	9
56	R:R:D82	R:R:S393	5.89	Yes	No	0	9	9
57	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
58	R:R:M84	R:R:W161	5.82	No	Yes	0	7	9
59	R:R:S393	R:R:V85	6.46	No	No	0	9	8
60	R:R:L115	R:R:L88	5.54	No	No	0	5	6
61	R:R:F112	R:R:V89	3.93	Yes	No	1	6	8
62	R:R:D116	R:R:V89	10.22	Yes	No	1	8	8
63	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
64	R:R:L90	R:R:W387	5.69	Yes	Yes	1	8	8
65	R:R:L90	R:R:Y390	7.03	Yes	Yes	1	8	8
66	R:R:M92	R:R:W102	4.65	No	Yes	1	6	9
67	R:R:F112	R:R:M92	7.46	Yes	No	1	6	6
68	R:R:A93	R:R:Y390	4	No	Yes	0	7	8
69	R:R:L95	R:R:L99	4.15	No	No	0	6	5
70	R:R:L104	R:R:L95	4.15	No	No	0	7	6
71	R:R:W102	R:R:Y96	8.68	Yes	No	0	9	6
72	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
73	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
74	R:R:L99	R:R:T103	7.37	No	No	0	5	5
75	R:R:K101	R:R:T103	4.5	No	No	0	5	5
76	R:R:D185	R:R:K101	12.44	No	No	0	4	5
77	R:R:L104	R:R:W102	12.53	No	Yes	1	7	9
78	R:R:T108	R:R:W102	3.64	No	Yes	1	6	9
79	R:R:C109	R:R:W102	6.53	No	Yes	1	9	9
80	R:R:F112	R:R:W102	10.02	Yes	Yes	1	6	9
81	R:R:C187	R:R:W102	16.98	No	Yes	1	9	9
82	R:R:L104	R:R:T108	5.9	No	No	1	7	6
83	R:R:G105	R:R:T108	3.64	No	No	0	7	6
84	R:R:D110	R:R:Q106	6.53	No	No	0	7	4
85	R:R:C109	R:R:C187	7.28	No	No	1	9	9
86	R:R:D110	R:R:R176	4.76	No	No	0	7	6
87	R:R:L111	R:R:L115	5.54	No	No	0	5	5
88	R:R:F112	R:R:I113	3.77	Yes	No	0	6	7
89	R:R:I113	R:R:R176	3.76	No	No	0	7	6
90	R:R:I113	R:R:I189	4.42	No	Yes	0	7	6
91	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
92	R:R:D116	R:R:Y390	12.64	Yes	Yes	1	8	8
93	R:R:L118	R:R:W161	5.69	No	Yes	0	6	9
94	R:R:F165	R:R:L118	14.61	No	No	0	5	6
95	R:R:L118	R:R:S168	6.01	No	No	0	6	8
96	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
97	R:R:G164	R:R:T121	3.64	No	No	0	8	8
98	R:R:I167	R:R:T121	6.08	No	No	0	8	8
99	R:R:A203	R:R:T121	5.03	No	No	0	8	8
100	R:R:H126	R:R:S122	4.18	Yes	No	1	8	8
101	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
102	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
103	R:R:I124	R:R:W358	10.57	No	Yes	1	8	8
104	R:R:C128	R:R:W125	3.92	No	No	1	7	7
105	R:R:I163	R:R:W125	21.14	No	No	0	5	7
106	R:R:P207	R:R:W125	18.92	Yes	No	1	9	7
107	R:R:H126	R:R:I157	6.63	Yes	No	1	8	8
108	R:R:H126	R:R:T160	16.43	Yes	No	1	8	8
109	R:R:H126	R:R:W161	4.23	Yes	Yes	1	8	9
110	R:R:L127	R:R:M211	4.24	Yes	Yes	1	8	9
111	R:R:F354	R:R:L127	4.87	Yes	Yes	1	9	8
112	R:R:L127	R:R:N396	9.61	Yes	Yes	1	8	9
113	R:R:L127	R:R:Y400	7.03	Yes	Yes	1	8	9
114	R:R:C128	R:R:P207	3.77	No	Yes	1	7	9
115	R:R:A129	R:R:L156	6.3	No	No	0	8	6
116	R:R:I130	R:R:R134	6.26	No	No	1	9	9
117	R:R:I130	R:R:Y400	8.46	No	Yes	1	9	9
118	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
119	R:R:L132	R:R:W136	15.94	No	No	0	6	5
120	R:R:L132	R:R:L214	5.54	No	No	0	6	7
121	R:R:D133	R:R:R148	13.1	Yes	Yes	3	9	8
122	R:R:R134	R:R:Y215	8.23	No	Yes	1	9	9
123	R:R:R134	R:R:Y400	7.2	No	Yes	1	9	9
124	R:R:W136	R:R:Y135	4.82	No	Yes	0	5	9
125	R:R:T139	R:R:Y135	14.98	No	Yes	0	8	9
126	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
127	R:R:R217	R:R:Y135	13.38	No	Yes	0	7	9
128	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
129	R:R:R152	R:R:W136	9	No	No	0	7	5
130	R:R:A137	R:R:Y144	4	No	No	0	8	8
131	R:R:I138	R:R:I218	4.42	No	No	0	9	9
132	R:R:D140	R:R:D143	7.98	No	No	0	7	6
133	R:R:D143	R:R:K147	4.15	No	No	0	6	5
134	R:R:D143	R:R:R152	13.1	No	No	0	6	7
135	R:R:R148	R:R:Y144	13.38	Yes	No	0	8	8
136	R:R:N146	R:R:V145	4.43	No	No	0	5	6
137	R:R:R148	R:R:R152	4.26	Yes	No	0	8	7
138	R:R:P150	R:R:T149	5.25	No	No	0	5	8
139	R:R:I163	R:R:L159	4.28	No	No	0	5	3
140	R:R:T160	R:R:W161	3.64	No	Yes	1	8	9
141	R:R:F165	R:R:I169	7.54	No	No	0	5	6
142	R:R:I167	R:R:Y198	6.04	No	Yes	0	8	5
143	R:R:I169	R:R:L173	4.28	No	No	0	6	6
144	R:R:P170	R:R:P171	5.84	No	No	0	8	7
145	R:R:P170	R:R:W175	6.76	No	Yes	4	8	6
146	R:R:P170	R:R:Y198	4.17	No	Yes	4	8	5
147	R:R:P171	R:R:Y195	13.91	No	Yes	0	7	8
148	R:R:D192	R:R:W175	12.28	No	Yes	0	6	6
149	R:R:W175	R:R:Y195	11.58	Yes	Yes	0	6	8
150	R:R:W175	R:R:Y198	6.75	Yes	Yes	4	6	5
151	R:R:R176	R:R:S190	6.59	No	No	0	6	6
152	R:R:I189	R:R:K191	4.36	Yes	No	0	6	5
153	R:R:I189	R:R:Y195	3.63	Yes	Yes	0	6	8
154	R:R:S190	R:R:Y195	7.63	No	Yes	0	6	8
155	R:R:K191	R:R:P369	5.02	No	No	0	5	7
156	R:R:F370	R:R:H193	20.36	No	No	0	5	4
157	R:R:S199	R:R:Y195	16.53	No	Yes	0	8	8
158	R:R:P369	R:R:T196	10.49	No	No	0	7	7
159	R:R:F370	R:R:T196	3.89	No	No	0	5	7
160	R:R:F370	R:R:I197	6.28	No	No	0	5	7
161	R:R:T200	R:R:Y205	4.99	No	Yes	1	7	7
162	R:R:F362	R:R:T200	5.19	Yes	No	1	7	7
163	R:R:L366	R:R:T200	8.84	No	No	1	7	7
164	R:R:F201	R:R:Y205	16.5	No	Yes	1	5	7
165	R:R:F201	R:R:L366	7.31	No	No	1	5	7
166	R:R:F204	R:R:Y205	9.28	Yes	Yes	1	8	7
167	R:R:F204	R:R:L208	10.96	Yes	No	1	8	7
168	R:R:F204	R:R:F354	7.5	Yes	Yes	1	8	9
169	R:R:F204	R:R:W358	4.01	Yes	Yes	1	8	8
170	R:R:F204	R:R:L359	8.53	Yes	No	0	8	7
171	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
172	R:R:L366	R:R:Y205	9.38	No	Yes	1	7	7
173	R:R:L208	R:R:L212	5.54	No	No	0	7	6
174	R:R:F354	R:R:L208	7.31	Yes	No	1	9	7
175	R:R:M211	R:R:Y215	4.79	Yes	Yes	1	9	9
176	R:R:M211	R:R:M351	10.11	Yes	No	1	9	8
177	R:R:F354	R:R:M211	7.46	Yes	Yes	1	9	9
178	R:R:L212	R:R:M351	4.24	No	No	0	6	8
179	R:R:R217	R:R:V213	3.92	No	No	0	7	5
180	R:R:I218	R:R:Y215	7.25	No	Yes	0	9	9
181	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
182	R:R:I350	R:R:Y215	8.46	No	Yes	0	8	9
183	R:R:M351	R:R:Y215	8.38	No	Yes	1	8	9
184	R:R:R217	R:R:R220	7.46	No	No	0	7	5
185	R:R:F219	R:R:R223	16.03	Yes	No	0	6	7
186	R:R:F219	R:R:T343	3.89	Yes	No	0	6	8
187	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
188	R:R:R223	R:R:R227	4.26	No	No	5	7	6
189	R:R:E340	R:R:R223	12.79	Yes	No	5	8	7
190	R:R:F224	R:R:K228	6.2	No	No	0	6	5
191	R:R:R225	R:R:T229	9.06	No	No	0	7	4
192	R:R:I226	R:R:R339	5.01	No	No	0	6	7
193	R:R:E340	R:R:I226	5.47	Yes	No	0	8	6
194	R:R:E340	R:R:R227	15.12	Yes	No	5	8	6
195	R:R:A336	R:R:V230	5.09	No	No	0	5	3
196	R:R:M335	R:R:R339	11.17	No	No	0	4	7
197	R:R:I349	R:R:K345	4.36	No	No	0	7	7
198	R:R:F403	R:R:I349	3.77	No	No	0	8	7
199	R:R:I350	R:R:Y400	4.84	No	Yes	0	8	9
200	R:R:L395	R:R:T353	4.42	No	No	0	6	7
201	R:R:I399	R:R:T353	7.6	No	No	0	8	7
202	R:R:F354	R:R:W358	5.01	Yes	Yes	1	9	8
203	R:R:I355	R:R:L359	4.28	No	No	0	7	7
204	R:R:C357	R:R:N392	9.45	No	No	0	8	9
205	R:R:F361	R:R:W358	7.02	Yes	Yes	1	8	8
206	R:R:F362	R:R:W358	10.02	Yes	Yes	1	7	8
207	R:R:G389	R:R:W358	11.26	No	Yes	0	8	8
208	R:R:N392	R:R:W358	9.04	No	Yes	0	9	8
209	R:R:I363	R:R:L359	7.14	No	No	0	7	7
210	R:R:F361	R:R:F362	10.72	Yes	Yes	1	8	7
211	R:R:A365	R:R:F361	4.16	No	Yes	0	8	8
212	R:R:F361	R:R:I385	5.02	Yes	Yes	0	8	6
213	R:R:F361	R:R:N386	14.5	Yes	No	1	8	7
214	R:R:L368	R:R:V364	4.47	No	No	0	4	6
215	R:R:M377	R:R:V364	4.56	No	No	0	4	6
216	R:R:I385	R:R:V364	4.61	Yes	No	0	6	6
217	R:R:C371	R:R:C375	7.28	No	No	6	5	4
218	R:R:E372	R:R:S373	5.75	No	No	0	3	3
219	R:R:C375	R:R:S374	5.16	No	No	0	4	5
220	R:R:M377	R:R:P378	5.03	No	No	0	4	7
221	R:R:L381	R:R:M377	5.65	No	No	0	6	4
222	R:R:I384	R:R:L380	4.28	No	No	0	4	3
223	R:R:N386	R:R:Y390	12.79	No	Yes	1	7	8
224	R:R:W387	R:R:Y390	18.33	Yes	Yes	1	8	8
225	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
226	R:R:N396	R:R:Y400	4.65	Yes	Yes	1	9	9
227	R:R:V398	R:R:Y402	3.79	No	Yes	0	6	6
228	R:R:F403	R:R:V398	5.24	No	No	0	8	6
229	R:R:I399	R:R:Y400	9.67	No	Yes	0	8	9
230	R:R:A401	R:R:F407	9.71	No	Yes	0	8	8
231	R:R:F411	R:R:Y402	10.32	Yes	Yes	0	8	6
232	R:R:D406	R:R:N404	4.04	No	No	0	7	9
233	R:R:F407	R:R:N404	7.25	Yes	No	0	8	9
234	R:R:F407	R:R:F411	4.29	Yes	Yes	0	8	8
235	R:R:G44	R:R:I47	3.53	No	No	0	4	7
236	R:R:G76	R:R:I61	3.53	No	No	0	6	8
237	R:R:P150	R:R:V70	3.53	No	Yes	0	5	7
238	R:R:G382	R:R:I385	3.53	No	Yes	0	4	6
239	R:R:A50	R:R:S86	3.42	No	No	0	8	8
240	R:R:C119	R:R:V85	3.42	No	No	0	7	8
241	R:R:A79	R:R:V57	3.39	No	No	0	9	9
242	R:R:A153	R:R:V70	3.39	No	Yes	0	7	7
243	R:R:I124	R:R:P207	3.39	No	Yes	1	8	9
244	R:R:I206	R:R:P207	3.39	No	Yes	0	6	9
245	R:R:I385	R:R:P360	3.39	Yes	No	0	6	9
246	R:R:A222	R:R:T343	3.36	No	No	0	8	8
247	R:R:S40	R:R:V98	3.23	No	No	0	5	6
248	R:R:A114	R:R:M172	3.22	No	No	0	7	6
249	R:R:D140	R:R:P141	3.22	No	No	0	7	8
250	R:R:V51	R:R:V87	3.21	No	No	0	7	6
251	R:R:T39	R:R:V98	3.17	No	No	0	5	6
252	R:R:C49	R:R:L394	3.17	No	No	0	5	7
253	R:R:C56	R:R:L52	3.17	No	No	0	8	4
254	R:R:A94	R:R:L43	3.15	No	No	0	7	7
255	R:R:A55	R:R:L83	3.15	No	No	0	5	8
256	R:R:A79	R:R:N54	3.13	No	No	0	9	9
257	R:R:L67	R:R:S66	3	Yes	No	0	8	6
258	R:R:L90	R:R:S86	3	Yes	No	0	8	8
259	R:R:L88	R:R:V87	2.98	No	No	0	6	6
260	R:R:L43	R:R:T39	2.95	No	No	0	7	5
261	R:R:I206	R:R:L210	2.85	No	No	0	6	7
262	R:R:L88	R:R:M84	2.83	No	No	0	6	7
263	R:R:D140	R:R:I142	2.8	No	No	0	7	6
264	R:R:K147	R:R:N146	2.8	No	No	0	5	5
265	R:R:K405	R:R:N409	2.8	No	No	0	6	6
266	R:R:K412	R:R:N409	2.8	No	No	0	6	6
267	R:R:C56	R:R:F411	2.79	No	Yes	0	8	8
268	R:R:A155	R:R:R151	2.77	No	No	0	3	6
269	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
270	R:R:G202	R:R:I167	1.76	No	No	0	5	8
271	R:R:A114	R:R:S168	1.71	No	No	0	7	8
272	R:R:G352	R:R:L356	1.71	No	No	0	6	5
273	R:R:C371	R:R:V367	1.71	No	No	0	5	6
274	R:R:G389	R:R:L388	1.71	No	No	0	8	8
275	R:R:A79	R:R:V58	1.7	No	No	0	9	7
276	R:R:C49	R:R:T45	1.69	No	No	0	5	4
277	R:R:I47	R:R:P91	1.69	No	No	0	7	9
278	R:R:A221	R:R:T139	1.68	No	No	0	6	8
279	R:R:A186	R:R:T188	1.68	No	No	0	4	5
280	R:R:D192	R:R:G194	1.68	No	No	0	6	5
281	R:R:S373	R:R:S374	1.63	No	No	0	3	5
282	R:R:A336	R:R:I226	1.62	No	No	0	5	6
283	R:R:C371	R:R:L368	1.59	No	No	6	5	4
284	R:R:C375	R:R:L368	1.59	No	No	6	4	4
285	R:R:A71	R:R:D133	1.54	No	Yes	0	8	9
286	R:R:K332	R:R:V230	1.52	No	No	0	6	3
287	R:R:I350	R:R:T346	1.52	No	No	0	8	8
288	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
289	R:R:K191	R:R:T188	1.5	No	No	0	5	5
290	R:R:K342	R:R:T346	1.5	No	No	0	8	8
291	R:R:L41	R:R:V37	1.49	No	No	0	4	5
292	R:R:I355	R:R:L356	1.43	No	No	0	7	5
293	R:R:I384	R:R:L388	1.43	No	No	0	4	8
294	R:R:K405	R:R:N404	1.4	No	No	0	6	9
295	R:R:A154	R:R:R151	1.38	No	No	0	4	6
296	R:R:L162	R:R:L166	1.38	No	No	0	5	5
297	R:R:A338	R:R:R341	1.38	No	No	0	5	6
298	R:R:H376	R:R:T379	1.37	No	No	0	2	2
299	R:R:K405	R:R:Q408	1.36	No	No	0	6	9
300	R:R:E340	R:R:L337	1.33	Yes	No	0	8	5
301	R:R:R151	R:R:T149	1.29	No	No	0	6	8
302	R:R:S34	R:R:Y35	1.27	No	No	0	3	4
303	R:R:F48	R:R:L52	1.22	No	No	0	4	4
304	R:R:L166	R:R:Y198	1.17	No	Yes	0	5	5
305	R:R:E330	R:R:R333	1.16	No	No	0	4	4
306	R:R:Q36	R:R:Y35	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.951	10	1	0
2	R:R:E64	5.746	5	2	7
3	R:R:L67	5.38667	6	2	8
4	R:R:V70	7.075	4	3	7
5	R:R:L78	7.11667	6	1	9
6	R:R:D82	6.652	5	1	9
7	R:R:L90	6.4275	4	1	8
8	R:R:W102	9.00429	7	1	9
9	R:R:F112	6.295	4	1	6
10	R:R:D116	12.1525	4	1	8
11	R:R:H126	8.15714	7	1	8
12	R:R:L127	5.98	5	1	8
13	R:R:D133	6.1125	4	3	9
14	R:R:Y135	8.534	5	0	9
15	R:R:R148	11.935	4	3	8
16	R:R:W161	7.73333	6	1	9
17	R:R:W175	9.3425	4	4	6
18	R:R:I189	5.1175	4	0	6
19	R:R:Y195	10.656	5	0	8
20	R:R:Y198	4.5325	4	4	5
21	R:R:F204	10.1067	6	1	8
22	R:R:Y205	10.0375	4	1	7
23	R:R:P207	7.3675	4	1	9
24	R:R:M211	6.65	4	1	9
25	R:R:Y215	6.92429	7	1	9
26	R:R:F219	5.54	5	0	6
27	R:R:E340	8.6775	4	5	8
28	R:R:F354	6.195	6	1	9
29	R:R:W358	7.35222	9	1	8
30	R:R:F361	9.625	6	1	8
31	R:R:F362	11.494	5	1	7
32	R:R:I385	4.1375	4	0	6
33	R:R:W387	11.36	4	1	8
34	R:R:Y390	9.90571	7	1	8
35	R:R:N396	9.666	5	1	9
36	R:R:Y400	6.4225	8	1	9
37	R:R:Y402	5.8775	4	0	6
38	R:R:F407	7.21833	6	2	8
39	R:R:F411	5.7375	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	41.9371	10.76	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	14.2559	18.33	Yes	Yes	1	8	8
3	R:R:L43	R:R:W387	10.9006	15.94	No	Yes	0	7	8
4	R:R:L90	R:R:Y390	14.4155	7.03	Yes	Yes	1	8	8
5	L:L:?1	R:R:W358	96.6038	4.02	Yes	Yes	1	0	8
6	R:R:F354	R:R:W358	64.4789	5.01	Yes	Yes	1	9	8
7	R:R:F354	R:R:L127	32.931	4.87	Yes	Yes	1	9	8
8	R:R:L127	R:R:L78	37.0023	4.15	Yes	Yes	1	8	9
9	R:R:H126	R:R:L78	55.9884	7.71	Yes	Yes	1	8	9
10	R:R:H126	R:R:W161	40.9141	4.23	Yes	Yes	1	8	9
11	R:R:M84	R:R:W161	20.8151	5.82	No	Yes	0	7	9
12	R:R:L88	R:R:M84	18.2413	2.83	No	No	0	6	7
13	R:R:L88	R:R:V87	10.471	2.98	No	No	0	6	6
14	R:R:N392	R:R:W358	55.0964	9.04	No	Yes	0	9	8
15	R:R:N392	R:R:N396	55.1455	12.26	No	Yes	0	9	9
16	R:R:L78	R:R:N396	15.9049	13.73	Yes	Yes	1	9	9
17	R:R:D82	R:R:N396	64.8922	8.08	Yes	Yes	1	9	9
18	R:R:D82	R:R:N54	100	6.73	Yes	No	0	9	9
19	R:R:A79	R:R:N54	94.877	3.13	No	No	0	9	9
20	R:R:A79	R:R:V57	87.1312	3.39	No	No	0	9	9
21	R:R:V57	R:R:Y402	29.9726	5.05	No	Yes	0	9	6
22	R:R:A401	R:R:V57	54.6053	5.09	No	No	0	8	9
23	R:R:F411	R:R:Y402	14.2314	10.32	Yes	Yes	0	8	6
24	R:R:A401	R:R:F407	51.9498	9.71	No	Yes	0	8	8
25	R:R:F407	R:R:L67	22.4641	9.74	Yes	Yes	2	8	8
26	R:R:E64	R:R:L67	11.4039	5.3	Yes	Yes	2	7	8
27	R:R:F407	R:R:N404	16.9238	7.25	Yes	No	0	8	9
28	R:R:F354	R:R:M211	45.2678	7.46	Yes	Yes	1	9	9
29	R:R:M211	R:R:Y215	69.0004	4.79	Yes	Yes	1	9	9
30	R:R:I218	R:R:Y215	93.0275	7.25	No	Yes	0	9	9
31	R:R:I218	R:R:Y135	88.3465	3.63	No	Yes	0	9	9
32	R:R:W136	R:R:Y135	68.8776	4.82	No	Yes	0	5	9
33	R:R:R152	R:R:W136	64.0656	9	No	No	0	7	5
34	R:R:R148	R:R:R152	44.1385	4.26	Yes	No	0	8	7
35	R:R:R148	R:R:V70	23.5239	17	Yes	Yes	3	8	7
36	R:R:P150	R:R:V70	18.4991	3.53	No	Yes	0	5	7
37	R:R:D133	R:R:R148	12.9833	13.1	Yes	Yes	3	9	8
38	R:R:N396	R:R:Y400	28.3645	4.65	Yes	Yes	1	9	9
39	R:R:I130	R:R:L78	16.5678	4.28	No	Yes	1	9	9
40	L:L:?1	R:R:I189	44.6172	8.06	Yes	Yes	0	0	6
41	R:R:I113	R:R:I189	19.4607	4.42	No	Yes	0	7	6
42	R:R:F112	R:R:I113	15.733	3.77	Yes	No	0	6	7
43	L:L:?1	R:R:D116	15.6962	21.08	Yes	Yes	1	0	8
44	R:R:D116	R:R:V89	27.0347	10.22	Yes	No	1	8	8
45	R:R:F112	R:R:V89	41.4215	3.93	Yes	No	1	6	8
46	R:R:V89	R:R:Y390	17.3902	3.79	No	Yes	1	8	8
47	R:R:F112	R:R:W102	48.3121	10.02	Yes	Yes	1	6	9
48	R:R:L104	R:R:W102	24.2768	12.53	No	Yes	1	7	9
49	R:R:L104	R:R:L95	20.2913	4.15	No	No	0	7	6
50	R:R:L95	R:R:L99	16.2486	4.15	No	No	0	6	5
51	R:R:L99	R:R:T103	12.1977	7.37	No	No	0	5	5
52	R:R:L118	R:R:W161	18.2413	5.69	No	Yes	0	6	9
53	R:R:I189	R:R:Y195	18.8551	3.63	Yes	Yes	0	6	8
54	R:R:W175	R:R:Y195	27.4561	11.58	Yes	Yes	0	6	8
55	R:R:W175	R:R:Y198	18.3927	6.75	Yes	Yes	4	6	5
56	R:R:I167	R:R:Y198	11.5962	6.04	No	Yes	0	8	5
57	L:L:?1	R:R:S199	18.5646	7.42	Yes	No	0	0	8
58	R:R:S199	R:R:Y195	17.4475	16.53	No	Yes	0	8	8
59	R:R:I124	R:R:P207	11.6821	3.39	No	Yes	1	8	9
60	R:R:R134	R:R:Y400	27.6484	7.2	No	Yes	1	9	9
61	R:R:R134	R:R:Y215	41.757	8.23	No	Yes	1	9	9
62	R:R:D143	R:R:R152	18.4909	13.1	No	No	0	6	7
63	R:R:P150	R:R:T149	10.6183	5.25	No	No	0	5	8
64	R:R:F204	R:R:L359	11.1461	8.53	Yes	No	0	8	7
65	R:R:L347	R:R:Y215	41.4665	4.69	No	Yes	0	8	9
66	R:R:I350	R:R:Y400	31.5398	4.84	No	Yes	0	8	9
67	R:R:I350	R:R:Y215	28.876	8.46	No	Yes	0	8	9
68	R:R:F219	R:R:L347	38.9091	3.65	Yes	No	0	6	8
69	R:R:F219	R:R:R223	26.2163	16.03	Yes	No	0	6	7
70	R:R:E340	R:R:R223	20.9829	12.79	Yes	No	5	8	7
71	R:R:E340	R:R:I226	15.864	5.47	Yes	No	0	8	6
72	R:R:V398	R:R:Y402	11.2852	3.79	No	Yes	0	6	6
73	R:R:F361	R:R:I385	21.5393	5.02	Yes	Yes	0	8	6
74	R:R:I385	R:R:V364	17.0302	4.61	Yes	No	0	6	6
75	R:R:L368	R:R:V364	11.0234	4.47	No	No	0	4	6
76	R:R:K405	R:R:N404	11.453	1.4	No	No	0	6	9
77	R:R:C120	R:R:D116	13.282	4.67	No	Yes	1	7	8
78	R:R:C120	R:R:W358	14.0227	5.22	No	Yes	1	7	8
79	R:R:F361	R:R:W358	14.0063	7.02	Yes	Yes	1	8	8
80	R:R:D82	R:R:L78	47.7679	8.14	Yes	Yes	1	9	9
81	R:R:L127	R:R:M211	26.4004	4.24	Yes	Yes	1	8	9
82	R:R:I130	R:R:R134	15.1316	6.26	No	No	1	9	9
83	R:R:L78	R:R:Y400	31.642	4.69	Yes	Yes	1	9	9
84	R:R:L127	R:R:N396	14.3705	9.61	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D116	21.08	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V117	10.52	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	5.6	1	Yes	No	0	7	0	1
L:L:?1	R:R:I189	8.06	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S199	7.42	1	Yes	No	0	8	0	1
L:L:?1	R:R:W358	4.02	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F361	16.33	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	11.18	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	14.54	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	10.76	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	10.22	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:W387	5.69	1	Yes	Yes	8	8	2	2
R:R:L90	R:R:Y390	7.03	1	Yes	Yes	8	8	2	1
R:R:A93	R:R:Y390	4	0	No	Yes	7	8	2	1
R:R:I113	R:R:I189	4.42	0	No	Yes	7	6	2	1
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	12.64	1	Yes	Yes	8	8	1	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	1
R:R:F354	R:R:I124	5.02	1	Yes	No	9	8	2	2
R:R:I124	R:R:W358	10.57	1	No	Yes	8	8	2	1
R:R:I189	R:R:K191	4.36	0	Yes	No	6	5	1	2
R:R:I189	R:R:Y195	3.63	0	Yes	Yes	6	8	1	2
R:R:S199	R:R:Y195	16.53	0	No	Yes	8	8	1	2
R:R:F362	R:R:T200	5.19	1	Yes	No	7	7	1	2
R:R:F204	R:R:F354	7.5	1	Yes	Yes	8	9	2	2
R:R:F204	R:R:W358	4.01	1	Yes	Yes	8	8	2	1
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F354	R:R:W358	5.01	1	Yes	Yes	9	8	2	1
R:R:F361	R:R:W358	7.02	1	Yes	Yes	8	8	1	1
R:R:F362	R:R:W358	10.02	1	Yes	Yes	7	8	1	1
R:R:G389	R:R:W358	11.26	0	No	Yes	8	8	2	1
R:R:N392	R:R:W358	9.04	0	No	Yes	9	8	2	1
R:R:F361	R:R:F362	10.72	1	Yes	Yes	8	7	1	1
R:R:A365	R:R:F361	4.16	0	No	Yes	8	8	2	1
R:R:F361	R:R:I385	5.02	1	Yes	Yes	8	6	1	2
R:R:F361	R:R:N386	14.5	1	Yes	No	8	7	1	1
R:R:N386	R:R:Y390	12.79	1	No	Yes	7	8	1	1
R:R:W387	R:R:Y390	18.33	1	Yes	Yes	8	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9VNF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	262
Number of Links	306
Number of Hubs	39
Number of Links mediated by Hubs	161
Number of Communities	6
Number of Nodes involved in Communities	63
Number of Links involved in Communities	98

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	73060
Length Of Smallest Path	3
Average Path Length	12.5837
Length of Longest Path	25
Minimum Path Strength	1.2
Average Path Strength	6.74917
Maximum Path Strength	20.03
Minimum Path Correlation	0.7
Average Path Correlation	0.924579
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	51.2731
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2359
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • periplasmic space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • heart process • regulation of heart contraction • heart contraction • locomotory behavior • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9VNF_nogp_Chain_R S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9VNF_nogp.zip

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