psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A93	6.18	Yes	No	1	0	7
2	L:L:?1	R:R:Y96	9.96	Yes	Yes	1	0	6
3	L:L:?1	R:R:D116	22.18	Yes	No	1	0	8
4	L:L:?1	R:R:V117	14.61	Yes	No	0	0	8
5	L:L:?1	R:R:C120	4.15	Yes	No	0	0	7
6	L:L:?1	R:R:F361	15.13	Yes	Yes	1	0	8
7	L:L:?1	R:R:F362	4.78	Yes	Yes	1	0	7
8	L:L:?1	R:R:N386	8.98	Yes	No	1	0	7
9	L:L:?1	R:R:Y390	9.2	Yes	Yes	1	0	8
10	R:R:S34	R:R:V37	6.46	No	No	0	3	5
11	R:R:Q36	R:R:V98	4.3	No	No	0	4	6
12	R:R:S40	R:R:V98	8.08	No	No	0	5	6
13	R:R:A94	R:R:L43	4.73	No	No	0	7	7
14	R:R:L43	R:R:W387	17.08	No	Yes	0	7	8
15	R:R:G44	R:R:I47	3.53	No	No	0	4	7
16	R:R:I47	R:R:L90	8.56	No	Yes	0	7	8
17	R:R:A50	R:R:S86	3.42	No	No	0	8	8
18	R:R:V51	R:R:V87	4.81	No	No	2	7	6
19	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
20	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
21	R:R:L83	R:R:N54	4.12	Yes	No	0	8	9
22	R:R:N54	R:R:P397	13.03	No	No	0	9	9
23	R:R:C56	R:R:Y402	4.03	No	Yes	0	8	6
24	R:R:A79	R:R:V57	3.39	No	Yes	0	9	9
25	R:R:P397	R:R:V57	3.53	No	Yes	0	9	9
26	R:R:A401	R:R:V57	5.09	No	Yes	3	8	9
27	R:R:V57	R:R:Y402	3.79	Yes	Yes	0	9	6
28	R:R:F407	R:R:V57	3.93	Yes	Yes	3	8	9
29	R:R:A60	R:R:F411	5.55	No	No	0	8	8
30	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
31	R:R:E64	R:R:K413	12.15	Yes	No	0	7	6
32	R:R:E64	R:R:I414	8.2	Yes	No	0	7	7
33	R:R:Q68	R:R:R65	3.5	No	No	0	8	7
34	R:R:F407	R:R:L67	10.96	Yes	No	0	8	8
35	R:R:A410	R:R:L67	4.73	No	No	0	8	8
36	R:R:Q68	R:R:Y73	7.89	No	No	0	8	6
37	R:R:N69	R:R:N72	12.26	No	No	0	8	9
38	R:R:R148	R:R:V70	15.69	Yes	No	0	8	7
39	R:R:P150	R:R:V70	5.3	No	No	0	5	7
40	R:R:A153	R:R:V70	3.39	No	No	0	7	7
41	R:R:F407	R:R:N72	6.04	Yes	No	0	8	9
42	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
43	R:R:D133	R:R:L74	4.07	No	No	0	9	8
44	R:R:L156	R:R:L74	5.54	No	No	0	6	8
45	R:R:I75	R:R:Y400	3.63	No	Yes	0	8	9
46	R:R:H126	R:R:S77	8.37	Yes	No	1	8	9
47	R:R:I157	R:R:S77	12.39	No	No	1	8	9
48	R:R:D82	R:R:L78	5.43	Yes	Yes	1	9	9
49	R:R:H126	R:R:L78	7.71	Yes	Yes	1	8	9
50	R:R:L127	R:R:L78	5.54	Yes	Yes	1	8	9
51	R:R:L78	R:R:N396	12.36	Yes	Yes	1	9	9
52	R:R:L78	R:R:Y400	3.52	Yes	Yes	1	9	9
53	R:R:S122	R:R:T81	7.99	No	Yes	1	8	9
54	R:R:S123	R:R:T81	4.8	No	Yes	0	9	9
55	R:R:H126	R:R:T81	12.32	Yes	Yes	1	8	9
56	R:R:T81	R:R:W161	12.13	Yes	Yes	1	9	9
57	R:R:D82	R:R:S123	8.83	Yes	No	0	9	9
58	R:R:D82	R:R:S393	8.83	Yes	No	0	9	9
59	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
60	R:R:M84	R:R:W161	5.82	No	Yes	0	7	9
61	R:R:C119	R:R:V85	3.42	No	No	0	7	8
62	R:R:S393	R:R:V85	8.08	No	No	0	9	8
63	R:R:L88	R:R:V87	4.47	No	No	0	6	6
64	R:R:L115	R:R:L88	4.15	No	No	0	5	6
65	R:R:D116	R:R:V89	11.69	No	No	1	8	8
66	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
67	R:R:L90	R:R:W387	5.69	Yes	Yes	1	8	8
68	R:R:L90	R:R:Y390	11.72	Yes	Yes	1	8	8
69	R:R:L95	R:R:M92	4.24	No	Yes	0	6	6
70	R:R:M92	R:R:W102	6.98	Yes	Yes	1	6	9
71	R:R:L104	R:R:M92	5.65	No	Yes	1	7	6
72	R:R:F112	R:R:M92	12.44	No	Yes	0	6	6
73	R:R:A93	R:R:Y390	4	No	Yes	1	7	8
74	R:R:L95	R:R:L99	6.92	No	No	0	6	5
75	R:R:W102	R:R:Y96	10.61	Yes	Yes	1	9	6
76	R:R:C187	R:R:Y96	4.03	Yes	Yes	1	9	6
77	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
78	R:R:Q97	R:R:W387	5.48	No	Yes	0	7	8
79	R:R:L99	R:R:T103	5.9	No	No	0	5	5
80	R:R:K101	R:R:T103	6.01	No	No	0	5	5
81	R:R:D185	R:R:K101	8.3	No	No	0	4	5
82	R:R:L104	R:R:W102	12.53	No	Yes	1	7	9
83	R:R:T108	R:R:W102	3.64	No	Yes	1	6	9
84	R:R:C109	R:R:W102	10.45	No	Yes	1	9	9
85	R:R:C187	R:R:W102	16.98	Yes	Yes	1	9	9
86	R:R:L104	R:R:T108	8.84	No	No	1	7	6
87	R:R:D110	R:R:Q106	10.44	No	No	0	7	4
88	R:R:C109	R:R:C187	7.28	No	Yes	1	9	9
89	R:R:D110	R:R:R176	9.53	No	No	0	7	6
90	R:R:F112	R:R:L111	3.65	No	No	0	6	5
91	R:R:I113	R:R:R176	5.01	No	No	0	7	6
92	R:R:A114	R:R:S168	3.42	No	No	0	7	8
93	R:R:D116	R:R:Y390	11.49	No	Yes	1	8	8
94	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
95	R:R:F165	R:R:L118	13.4	No	No	0	5	6
96	R:R:L118	R:R:S168	6.01	No	No	0	6	8
97	R:R:C120	R:R:W358	5.22	No	Yes	0	7	8
98	R:R:G164	R:R:T121	3.64	No	No	0	8	8
99	R:R:I167	R:R:T121	7.6	No	No	0	8	8
100	R:R:A203	R:R:T121	5.03	No	No	0	8	8
101	R:R:H126	R:R:S122	6.97	Yes	No	1	8	8
102	R:R:S122	R:R:W161	18.53	No	Yes	1	8	9
103	R:R:I124	R:R:P207	3.39	No	Yes	1	8	9
104	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
105	R:R:I124	R:R:W358	10.57	No	Yes	1	8	8
106	R:R:C128	R:R:W125	3.92	No	No	1	7	7
107	R:R:I163	R:R:W125	21.14	No	No	0	5	7
108	R:R:P207	R:R:W125	18.92	Yes	No	1	9	7
109	R:R:H126	R:R:I157	5.3	Yes	No	1	8	8
110	R:R:H126	R:R:T160	20.54	Yes	No	1	8	8
111	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
112	R:R:F354	R:R:L127	4.87	Yes	Yes	1	9	8
113	R:R:L127	R:R:N396	9.61	Yes	Yes	1	8	9
114	R:R:L127	R:R:Y400	7.03	Yes	Yes	1	8	9
115	R:R:C128	R:R:P207	3.77	No	Yes	1	7	9
116	R:R:A129	R:R:L156	6.3	No	No	0	8	6
117	R:R:I130	R:R:R134	7.52	No	No	1	9	9
118	R:R:I130	R:R:Y400	7.25	No	Yes	1	9	9
119	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
120	R:R:L132	R:R:W136	18.22	No	No	0	6	5
121	R:R:L132	R:R:L214	4.15	No	No	0	6	7
122	R:R:D133	R:R:R148	13.1	No	Yes	0	9	8
123	R:R:R134	R:R:Y215	8.23	No	Yes	1	9	9
124	R:R:R134	R:R:Y400	6.17	No	Yes	1	9	9
125	R:R:W136	R:R:Y135	4.82	No	Yes	0	5	9
126	R:R:T139	R:R:Y135	16.23	No	Yes	0	8	9
127	R:R:L214	R:R:Y135	7.03	No	Yes	0	7	9
128	R:R:R217	R:R:Y135	14.4	No	Yes	0	7	9
129	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
130	R:R:A137	R:R:Y144	4	No	No	0	8	8
131	R:R:I138	R:R:I218	4.42	No	No	0	9	9
132	R:R:D140	R:R:D143	7.98	No	No	0	7	6
133	R:R:D143	R:R:K147	4.15	No	No	0	6	5
134	R:R:D143	R:R:R152	11.91	No	No	0	6	7
135	R:R:R148	R:R:Y144	14.4	Yes	No	0	8	8
136	R:R:N146	R:R:V145	4.43	No	No	0	5	6
137	R:R:R148	R:R:R152	5.33	Yes	No	0	8	7
138	R:R:P150	R:R:T149	3.5	No	No	0	5	8
139	R:R:A155	R:R:R151	4.15	No	No	0	3	6
140	R:R:T160	R:R:W161	4.85	No	Yes	1	8	9
141	R:R:L162	R:R:L166	6.92	No	No	0	5	5
142	R:R:I167	R:R:Y198	6.04	No	No	0	8	5
143	R:R:I169	R:R:P170	3.39	No	No	0	6	8
144	R:R:I169	R:R:L173	4.28	No	No	0	6	6
145	R:R:P170	R:R:P171	5.84	No	No	0	8	7
146	R:R:P170	R:R:W175	9.46	No	Yes	0	8	6
147	R:R:P171	R:R:Y195	12.52	No	Yes	0	7	8
148	R:R:D192	R:R:W175	5.58	No	Yes	0	6	6
149	R:R:W175	R:R:Y195	7.72	Yes	Yes	0	6	8
150	R:R:W175	R:R:Y198	12.54	Yes	No	0	6	5
151	R:R:R176	R:R:S190	3.95	No	No	0	6	6
152	R:R:I189	R:R:K191	4.36	No	No	0	6	5
153	R:R:I189	R:R:Y195	7.25	No	Yes	0	6	8
154	R:R:S190	R:R:Y195	6.36	No	Yes	0	6	8
155	R:R:F370	R:R:H193	15.84	No	No	0	5	4
156	R:R:E372	R:R:H193	3.69	No	No	0	3	4
157	R:R:S199	R:R:Y195	13.99	No	Yes	0	8	8
158	R:R:P369	R:R:T196	12.24	No	No	0	7	7
159	R:R:F370	R:R:I197	6.28	No	No	0	5	7
160	R:R:T200	R:R:Y205	4.99	Yes	Yes	1	7	7
161	R:R:F362	R:R:T200	5.19	Yes	Yes	1	7	7
162	R:R:L366	R:R:T200	5.9	No	Yes	1	7	7
163	R:R:F201	R:R:Y205	11.35	No	Yes	0	5	7
164	R:R:F204	R:R:Y205	9.28	Yes	Yes	1	8	7
165	R:R:F204	R:R:L208	10.96	Yes	No	1	8	7
166	R:R:F204	R:R:F354	8.57	Yes	Yes	1	8	9
167	R:R:F204	R:R:L359	8.53	Yes	Yes	0	8	7
168	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
169	R:R:L366	R:R:Y205	7.03	No	Yes	1	7	7
170	R:R:I206	R:R:P207	3.39	No	Yes	0	6	9
171	R:R:L208	R:R:L212	5.54	No	No	0	7	6
172	R:R:F354	R:R:L208	3.65	Yes	No	1	9	7
173	R:R:M211	R:R:Y215	5.99	No	Yes	1	9	9
174	R:R:M211	R:R:M351	5.78	No	No	1	9	8
175	R:R:F354	R:R:M211	8.71	Yes	No	1	9	9
176	R:R:L212	R:R:M351	4.24	No	No	0	6	8
177	R:R:R217	R:R:V213	3.92	No	No	0	7	5
178	R:R:I218	R:R:Y215	4.84	No	Yes	0	9	9
179	R:R:L347	R:R:Y215	4.69	No	Yes	0	8	9
180	R:R:I350	R:R:Y215	8.46	No	Yes	0	8	9
181	R:R:M351	R:R:Y215	4.79	No	Yes	1	8	9
182	R:R:R217	R:R:R220	5.33	No	No	0	7	5
183	R:R:F219	R:R:R223	8.55	Yes	No	0	6	7
184	R:R:F219	R:R:L347	3.65	Yes	No	0	6	8
185	R:R:A222	R:R:T343	3.36	No	No	0	8	8
186	R:R:R223	R:R:R227	13.86	No	No	4	7	6
187	R:R:E340	R:R:R223	19.77	No	No	4	8	7
188	R:R:F224	R:R:K228	7.44	No	No	0	6	5
189	R:R:R225	R:R:T229	5.17	No	No	0	7	4
190	R:R:I226	R:R:R339	3.76	No	No	0	6	7
191	R:R:E340	R:R:R227	10.47	No	No	4	8	6
192	R:R:A336	R:R:V230	3.39	No	No	0	5	3
193	R:R:E330	R:R:R333	4.65	No	No	0	4	4
194	R:R:E330	R:R:K334	9.45	No	No	0	4	5
195	R:R:M335	R:R:R339	14.89	No	No	0	4	7
196	R:R:L337	R:R:R341	10.93	No	No	0	5	6
197	R:R:E340	R:R:R341	4.65	No	No	0	8	6
198	R:R:I349	R:R:K345	4.36	No	No	0	7	7
199	R:R:F403	R:R:I349	5.02	No	No	0	8	7
200	R:R:I350	R:R:Y400	4.84	No	Yes	0	8	9
201	R:R:I399	R:R:T353	9.12	No	No	0	8	7
202	R:R:F354	R:R:W358	5.01	Yes	Yes	1	9	8
203	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
204	R:R:C357	R:R:N392	9.45	No	No	0	8	9
205	R:R:F361	R:R:W358	7.02	Yes	Yes	1	8	8
206	R:R:F362	R:R:W358	8.02	Yes	Yes	1	7	8
207	R:R:G389	R:R:W358	11.26	No	Yes	0	8	8
208	R:R:N392	R:R:W358	10.17	No	Yes	0	9	8
209	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
210	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
211	R:R:I385	R:R:P360	3.39	No	No	0	6	9
212	R:R:L388	R:R:P360	3.28	No	No	0	8	9
213	R:R:F361	R:R:F362	16.08	Yes	Yes	1	8	7
214	R:R:A365	R:R:F361	4.16	No	Yes	0	8	8
215	R:R:F361	R:R:N386	6.04	Yes	No	1	8	7
216	R:R:M377	R:R:V364	6.09	Yes	No	0	4	6
217	R:R:I385	R:R:V364	4.61	No	No	0	6	6
218	R:R:L368	R:R:M377	4.24	No	Yes	0	4	4
219	R:R:C371	R:R:S374	3.44	No	No	0	5	5
220	R:R:C371	R:R:C375	7.28	No	No	5	5	4
221	R:R:M377	R:R:P378	6.71	Yes	No	0	4	7
222	R:R:L381	R:R:M377	4.24	No	Yes	0	6	4
223	R:R:G382	R:R:M377	3.49	No	Yes	0	4	4
224	R:R:I385	R:R:L381	7.14	No	No	0	6	6
225	R:R:W387	R:R:Y390	15.43	Yes	Yes	1	8	8
226	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
227	R:R:N396	R:R:Y400	4.65	Yes	Yes	1	9	9
228	R:R:F403	R:R:V398	5.24	No	No	0	8	6
229	R:R:I399	R:R:Y400	9.67	No	Yes	0	8	9
230	R:R:A401	R:R:F407	8.32	No	Yes	3	8	8
231	R:R:F411	R:R:Y402	8.25	No	Yes	0	8	6
232	R:R:F407	R:R:N404	7.25	Yes	No	0	8	9
233	R:R:K405	R:R:Q408	4.07	No	No	0	6	9
234	R:R:K405	R:R:N409	5.6	No	No	0	6	6
235	R:R:K412	R:R:N409	5.6	No	No	0	6	6
236	R:R:C109	R:R:I113	3.27	No	No	1	9	7
237	R:R:C187	R:R:I113	3.27	Yes	No	1	9	7
238	R:R:A114	R:R:M172	3.22	No	No	0	7	6
239	R:R:V58	R:R:V80	3.21	No	No	0	7	7
240	R:R:C56	R:R:L52	3.17	No	No	0	8	4
241	R:R:A50	R:R:L394	3.15	No	No	0	8	7
242	R:R:A55	R:R:L83	3.15	No	Yes	0	5	8
243	R:R:T196	R:R:T200	3.14	No	Yes	0	7	7
244	R:R:A410	R:R:E64	3.02	No	Yes	0	8	7
245	R:R:L46	R:R:S391	3	No	No	0	7	5
246	R:R:L90	R:R:S86	3	Yes	No	0	8	8
247	R:R:R152	R:R:W136	3	No	No	0	7	5
248	R:R:L83	R:R:V51	2.98	Yes	No	2	8	7
249	R:R:L83	R:R:V87	2.98	Yes	No	2	8	6
250	R:R:L99	R:R:V98	2.98	No	No	0	5	6
251	R:R:L43	R:R:T39	2.95	No	No	0	7	5
252	R:R:L347	R:R:T343	2.95	No	No	0	8	8
253	R:R:L395	R:R:T353	2.95	No	No	0	6	7
254	R:R:I349	R:R:I399	2.94	No	No	0	7	8
255	R:R:E64	R:R:S66	2.87	Yes	No	0	7	6
256	R:R:I38	R:R:L42	2.85	No	No	0	3	5
257	R:R:I414	R:R:L63	2.85	No	No	0	7	6
258	R:R:I206	R:R:L210	2.85	No	No	0	6	7
259	R:R:I384	R:R:L380	2.85	No	No	0	4	3
260	R:R:K147	R:R:N146	2.8	No	No	0	5	5
261	R:R:L394	R:R:L46	2.77	No	No	0	7	7
262	R:R:D406	R:R:N404	2.69	No	No	0	7	9
263	R:R:F219	R:R:V344	2.62	Yes	No	0	6	8
264	R:R:A79	R:R:G76	1.95	No	No	0	9	6
265	R:R:G105	R:R:T108	1.82	No	No	0	7	6
266	R:R:G202	R:R:I167	1.76	No	No	0	5	8
267	R:R:G202	R:R:I206	1.76	No	No	0	5	6
268	R:R:G352	R:R:I355	1.76	No	No	0	6	7
269	R:R:G174	R:R:L173	1.71	No	No	0	5	6
270	R:R:C371	R:R:V367	1.71	No	No	5	5	6
271	R:R:C375	R:R:V367	1.71	No	No	5	4	6
272	R:R:A79	R:R:V58	1.7	No	No	0	9	7
273	R:R:I47	R:R:P91	1.69	No	No	0	7	9
274	R:R:A221	R:R:T139	1.68	No	No	0	6	8
275	R:R:D192	R:R:G194	1.68	No	No	0	6	5
276	R:R:A336	R:R:I226	1.62	No	No	0	5	6
277	R:R:D140	R:R:P141	1.61	No	No	0	7	8
278	R:R:C49	R:R:L394	1.59	No	No	0	5	7
279	R:R:G194	R:R:H193	1.59	No	No	0	5	4
280	R:R:C375	R:R:L368	1.59	No	No	0	4	4
281	R:R:A59	R:R:L63	1.58	No	No	0	5	6
282	R:R:A71	R:R:N69	1.56	No	No	0	8	8
283	R:R:H376	R:R:P378	1.53	No	No	0	2	7
284	R:R:I38	R:R:T39	1.52	No	No	0	3	5
285	R:R:I226	R:R:T343	1.52	No	No	0	6	8
286	R:R:K332	R:R:V230	1.52	No	No	0	6	3
287	R:R:I350	R:R:T346	1.52	No	No	0	8	8
288	R:R:F219	R:R:G216	1.51	Yes	No	0	6	3
289	R:R:K191	R:R:T188	1.5	No	No	0	5	5
290	R:R:L209	R:R:V213	1.49	No	No	0	5	5
291	R:R:L42	R:R:T45	1.47	No	No	0	5	4
292	R:R:Q36	R:R:S34	1.44	No	No	0	4	3
293	R:R:I142	R:R:N146	1.42	No	No	0	6	5
294	R:R:L41	R:R:L42	1.38	No	No	0	4	5
295	R:R:L159	R:R:L162	1.38	No	No	0	3	5
296	R:R:A186	R:R:Y96	1.33	No	Yes	0	4	6
297	R:R:R151	R:R:T149	1.29	No	No	0	6	8
298	R:R:K228	R:R:R225	1.24	No	No	0	5	7
299	R:R:F48	R:R:L52	1.22	No	No	0	4	4
300	R:R:L166	R:R:Y198	1.17	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.5744	9	1	0
2	R:R:V57	3.946	5	3	9
3	R:R:E64	6.56	4	0	7
4	R:R:L78	6.912	5	1	9
5	R:R:T81	9.31	4	1	9
6	R:R:D82	7.58	5	1	9
7	R:R:L83	3.3075	4	2	8
8	R:R:L90	7.2425	4	1	8
9	R:R:M92	7.3275	4	1	6
10	R:R:Y96	6.4825	4	1	6
11	R:R:W102	10.1983	6	1	9
12	R:R:H126	9.5	7	1	8
13	R:R:L127	6.7625	4	1	8
14	R:R:Y135	9.222	5	0	9
15	R:R:R148	12.13	4	0	8
16	R:R:W161	8.90833	6	1	9
17	R:R:W175	8.825	4	0	6
18	R:R:C187	7.89	4	1	9
19	R:R:Y195	9.568	5	0	8
20	R:R:T200	4.805	4	1	7
21	R:R:F204	11.54	5	1	8
22	R:R:Y205	8.1625	4	1	7
23	R:R:P207	7.3675	4	1	9
24	R:R:Y215	6.23857	7	1	9
25	R:R:F219	4.0825	4	0	6
26	R:R:F354	5.97167	6	1	9
27	R:R:W358	8.18143	7	1	8
28	R:R:L359	5.8075	4	0	7
29	R:R:F361	9.686	5	1	8
30	R:R:F362	10.886	5	1	7
31	R:R:M377	4.954	5	0	4
32	R:R:W387	10.92	4	1	8
33	R:R:Y390	9.27167	6	1	8
34	R:R:N396	9.392	5	1	9
35	R:R:Y400	5.845	8	1	9
36	R:R:Y402	5.105	4	0	6
37	R:R:F407	7.13	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y96	85.223	9.96	Yes	Yes	1	0	6
2	R:R:W102	R:R:Y96	51.9181	10.61	Yes	Yes	1	9	6
3	R:R:M92	R:R:W102	41.4594	6.98	Yes	Yes	1	6	9
4	R:R:L95	R:R:M92	32.1058	4.24	No	Yes	0	6	6
5	R:R:L95	R:R:L99	28.9098	6.92	No	No	0	6	5
6	R:R:L99	R:R:V98	16.0401	2.98	No	No	0	5	6
7	L:L:?1	R:R:Y390	67.2413	9.2	Yes	Yes	1	0	8
8	R:R:W387	R:R:Y390	30.5697	15.43	Yes	Yes	1	8	8
9	R:R:L43	R:R:W387	22.0098	17.08	No	Yes	0	7	8
10	R:R:L90	R:R:Y390	31.0006	11.72	Yes	Yes	1	8	8
11	R:R:L90	R:R:S86	19.0954	3	Yes	No	0	8	8
12	R:R:A50	R:R:S86	15.9334	3.42	No	No	0	8	8
13	L:L:?1	R:R:C120	41.7495	4.15	Yes	No	0	0	7
14	R:R:C120	R:R:W358	42.3768	5.22	No	Yes	0	7	8
15	R:R:N392	R:R:W358	63.6996	10.17	No	Yes	0	9	8
16	R:R:N392	R:R:N396	62.2914	12.26	No	Yes	0	9	9
17	R:R:D82	R:R:N396	75.272	8.08	Yes	Yes	1	9	9
18	R:R:D82	R:R:N54	100	6.73	Yes	No	0	9	9
19	R:R:L83	R:R:N54	17.4312	4.12	Yes	No	0	8	9
20	L:L:?1	R:R:F361	41.7111	15.13	Yes	Yes	1	0	8
21	R:R:F361	R:R:W358	43.5502	7.02	Yes	Yes	1	8	8
22	L:L:?1	R:R:F362	72.1016	4.78	Yes	Yes	1	0	7
23	R:R:F362	R:R:W358	45.3936	8.02	Yes	Yes	1	7	8
24	R:R:N54	R:R:P397	81.421	13.03	No	No	0	9	9
25	R:R:P397	R:R:V57	78.7327	3.53	No	Yes	0	9	9
26	R:R:V57	R:R:Y402	20.3072	3.79	Yes	Yes	0	9	6
27	R:R:A79	R:R:V57	11.6535	3.39	No	Yes	0	9	9
28	R:R:F407	R:R:V57	42.9443	3.93	Yes	Yes	3	8	9
29	R:R:F407	R:R:L67	23.1747	10.96	Yes	No	0	8	8
30	R:R:A410	R:R:L67	20.3072	4.73	No	No	0	8	8
31	R:R:A410	R:R:E64	17.4312	3.02	No	Yes	0	8	7
32	R:R:F354	R:R:W358	65.8545	5.01	Yes	Yes	1	9	8
33	R:R:F354	R:R:M211	77.8451	8.71	Yes	No	1	9	9
34	R:R:M211	R:R:Y215	74.7301	5.99	No	Yes	1	9	9
35	R:R:I218	R:R:Y215	85.8332	4.84	No	Yes	0	9	9
36	R:R:I218	R:R:Y135	81.6812	3.63	No	Yes	0	9	9
37	R:R:W136	R:R:Y135	61.4338	4.82	No	Yes	0	5	9
38	R:R:R152	R:R:W136	56.9789	3	No	No	0	7	5
39	R:R:R148	R:R:R152	38.6132	5.33	Yes	No	0	8	7
40	R:R:R148	R:R:V70	22.1122	15.69	Yes	No	0	8	7
41	R:R:P150	R:R:V70	17.2605	5.3	No	No	0	5	7
42	R:R:F204	R:R:F362	31.9863	20.36	Yes	Yes	1	8	7
43	R:R:F204	R:R:F354	49.9168	8.57	Yes	Yes	1	8	9
44	R:R:F354	R:R:L127	60.9345	4.87	Yes	Yes	1	9	8
45	R:R:L127	R:R:Y400	17.0429	7.03	Yes	Yes	1	8	9
46	R:R:N396	R:R:Y400	33.2238	4.65	Yes	Yes	1	9	9
47	R:R:L127	R:R:L78	30.5782	5.54	Yes	Yes	1	8	9
48	R:R:H126	R:R:L78	35.7158	7.71	Yes	Yes	1	8	9
49	R:R:L78	R:R:N396	10.4502	12.36	Yes	Yes	1	9	9
50	R:R:H126	R:R:W161	19.4111	5.29	Yes	Yes	1	8	9
51	R:R:C187	R:R:Y96	28.1118	4.03	Yes	Yes	1	9	6
52	R:R:C187	R:R:I113	24.9285	3.27	Yes	No	1	9	7
53	R:R:I113	R:R:R176	24.6341	5.01	No	No	0	7	6
54	R:R:L118	R:R:W161	14.8453	6.83	No	Yes	0	6	9
55	R:R:I124	R:R:W358	15.814	10.57	No	Yes	1	8	8
56	R:R:I124	R:R:P207	43.0681	3.39	No	Yes	1	8	9
57	R:R:I206	R:R:P207	36.4455	3.39	No	Yes	0	6	9
58	R:R:G202	R:R:I206	33.1683	1.76	No	No	0	5	6
59	R:R:G202	R:R:I167	31.5639	1.76	No	No	0	5	8
60	R:R:R134	R:R:Y400	28.6793	6.17	No	Yes	1	9	9
61	R:R:R134	R:R:Y215	28.3337	8.23	No	Yes	1	9	9
62	R:R:D143	R:R:R152	17.2562	11.91	No	No	0	6	7
63	R:R:R176	R:R:S190	16.3047	3.95	No	No	0	6	6
64	R:R:S190	R:R:Y195	13.4841	6.36	No	Yes	0	6	8
65	R:R:W175	R:R:Y195	12.0418	7.72	Yes	Yes	0	6	8
66	R:R:W175	R:R:Y198	22.0568	12.54	Yes	No	0	6	5
67	R:R:I167	R:R:Y198	26.597	6.04	No	No	0	8	5
68	R:R:F204	R:R:L359	33.1982	8.53	Yes	Yes	0	8	7
69	R:R:L347	R:R:Y215	39.8848	4.69	No	Yes	0	8	9
70	R:R:I350	R:R:Y400	31.5468	4.84	No	Yes	0	8	9
71	R:R:I350	R:R:Y215	29.6522	8.46	No	Yes	0	8	9
72	R:R:F219	R:R:L347	19.2148	3.65	Yes	No	0	6	8
73	R:R:F219	R:R:R223	12.1357	8.55	Yes	No	0	6	7
74	R:R:L347	R:R:T343	18.7839	2.95	No	No	0	8	8
75	R:R:I226	R:R:T343	14.3503	1.52	No	No	0	6	8
76	R:R:I399	R:R:Y400	20.8449	9.67	No	Yes	0	8	9
77	R:R:I349	R:R:I399	11.9607	2.94	No	No	0	7	8
78	R:R:L359	R:R:P360	28.658	3.28	Yes	No	0	7	9
79	R:R:I385	R:R:P360	26.3367	3.39	No	No	0	6	9
80	R:R:I385	R:R:V364	12.5325	4.61	No	No	0	6	6
81	R:R:M377	R:R:V364	11.3079	6.09	Yes	No	0	4	6
82	R:R:I385	R:R:L381	12.6307	7.14	No	No	0	6	6
83	R:R:L381	R:R:M377	11.406	4.24	No	Yes	0	6	4
84	R:R:L368	R:R:M377	12.7544	4.24	No	Yes	0	4	4
85	R:R:C375	R:R:L368	10.2198	1.59	No	No	0	4	4
86	R:R:A50	R:R:L394	12.763	3.15	No	No	0	8	7
87	R:R:L43	R:R:T39	15.9334	2.95	No	No	0	7	5
88	R:R:I38	R:R:T39	12.763	1.52	No	No	0	3	5
89	R:R:L78	R:R:Y400	29.8016	3.52	Yes	Yes	1	9	9
90	R:R:D82	R:R:L78	36.8594	5.43	Yes	Yes	1	9	9
91	R:R:L127	R:R:N396	12.7288	9.61	Yes	Yes	1	8	9
92	R:R:F354	R:R:I124	28.9098	5.02	Yes	No	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A93	6.18	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y96	9.96	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:D116	22.18	1	Yes	No	0	8	0	1
L:L:?1	R:R:V117	14.61	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	4.15	1	Yes	No	0	7	0	1
L:L:?1	R:R:F361	15.13	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	4.78	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.98	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	9.2	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	11.69	1	No	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:W387	5.69	1	Yes	Yes	8	8	2	2
R:R:L90	R:R:Y390	11.72	1	Yes	Yes	8	8	2	1
R:R:A93	R:R:Y390	4	1	No	Yes	7	8	1	1
R:R:W102	R:R:Y96	10.61	1	Yes	Yes	9	6	2	1
R:R:C187	R:R:Y96	4.03	1	Yes	Yes	9	6	2	1
R:R:C187	R:R:W102	16.98	1	Yes	Yes	9	9	2	2
R:R:D116	R:R:Y390	11.49	1	No	Yes	8	8	1	1
R:R:C120	R:R:W358	5.22	0	No	Yes	7	8	1	2
R:R:F362	R:R:T200	5.19	1	Yes	Yes	7	7	1	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	7.02	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	8.02	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	16.08	1	Yes	Yes	8	7	1	1
R:R:A365	R:R:F361	4.16	0	No	Yes	8	8	2	1
R:R:F361	R:R:N386	6.04	1	Yes	No	8	7	1	1
R:R:W387	R:R:Y390	15.43	1	Yes	Yes	8	8	2	1
R:R:A186	R:R:Y96	1.33	0	No	Yes	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9VJE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	262
Number of Links	300
Number of Hubs	37
Number of Links mediated by Hubs	149
Number of Communities	5
Number of Nodes involved in Communities	58
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	76211
Length Of Smallest Path	3
Average Path Length	12.8983
Length of Longest Path	26
Minimum Path Strength	1.425
Average Path Strength	6.78513
Maximum Path Strength	20.03
Minimum Path Correlation	0.7
Average Path Correlation	0.924783
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	49.2185
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.691
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • periplasmic space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • heart process • regulation of heart contraction • heart contraction • locomotory behavior • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • establishment of protein localization • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • negative regulation of cellular process • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YLX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YLX
Name	Buspirone
Synonyms	Buspironum
Identifier
Formula	C21 H31 N5 O2
Molecular Weight	385.503
SMILES
PubChem	2477
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9VJE_nogp_Chain_R S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9VJE_nogp.zip

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