psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:A93	4.64	Yes	No	1	0	7
2	L:L:?1	R:R:Y96	7.6	Yes	No	1	0	6
3	L:L:?1	R:R:W102	5.37	Yes	Yes	1	0	9
4	L:L:?1	R:R:I113	6.73	Yes	No	1	0	7
5	L:L:?1	R:R:D116	15.2	Yes	Yes	1	0	8
6	L:L:?1	R:R:V117	10.54	Yes	No	0	0	8
7	L:L:?1	R:R:C120	5.61	Yes	No	1	0	7
8	L:L:?1	R:R:C187	4.68	Yes	No	1	0	9
9	L:L:?1	R:R:I189	10.94	Yes	No	1	0	6
10	L:L:?1	R:R:F361	18.66	Yes	Yes	1	0	8
11	L:L:?1	R:R:F362	7.18	Yes	Yes	1	0	7
12	L:L:?1	R:R:N386	8.9	Yes	No	1	0	7
13	L:L:?1	R:R:Y390	10.36	Yes	Yes	1	0	8
14	R:R:I38	R:R:Y35	3.63	No	No	0	3	4
15	R:R:S40	R:R:V98	4.85	No	No	0	5	6
16	R:R:A94	R:R:L43	4.73	No	No	0	7	7
17	R:R:L43	R:R:W387	17.08	No	Yes	0	7	8
18	R:R:L394	R:R:L46	4.15	No	No	0	7	7
19	R:R:I47	R:R:L90	8.56	No	Yes	0	7	8
20	R:R:I47	R:R:P91	5.08	No	No	0	7	9
21	R:R:C49	R:R:L394	4.76	No	No	0	5	7
22	R:R:G53	R:R:Y402	4.35	No	Yes	0	9	6
23	R:R:D82	R:R:N54	6.73	Yes	No	0	9	9
24	R:R:L83	R:R:N54	4.12	No	No	0	8	9
25	R:R:N54	R:R:P397	8.15	No	No	0	9	9
26	R:R:A401	R:R:V57	5.09	No	Yes	2	8	9
27	R:R:V57	R:R:Y402	6.31	Yes	Yes	0	9	6
28	R:R:F407	R:R:V57	3.93	Yes	Yes	2	8	9
29	R:R:V58	R:R:V80	4.81	No	No	0	7	7
30	R:R:A60	R:R:F411	4.16	No	No	0	8	8
31	R:R:F407	R:R:I61	6.28	Yes	No	0	8	8
32	R:R:E64	R:R:S66	7.19	Yes	No	0	7	6
33	R:R:E64	R:R:L67	6.63	Yes	Yes	0	7	8
34	R:R:A410	R:R:E64	6.03	No	Yes	0	8	7
35	R:R:Q68	R:R:R65	5.84	No	No	0	8	7
36	R:R:L67	R:R:N72	5.49	Yes	Yes	2	8	9
37	R:R:D406	R:R:L67	5.43	Yes	Yes	2	7	8
38	R:R:F407	R:R:L67	9.74	Yes	Yes	2	8	8
39	R:R:Q68	R:R:Y73	6.76	No	No	0	8	6
40	R:R:N69	R:R:N72	12.26	No	Yes	0	8	9
41	R:R:D133	R:R:V70	4.38	No	Yes	3	9	7
42	R:R:R148	R:R:V70	17	Yes	Yes	3	8	7
43	R:R:P150	R:R:V70	5.3	No	Yes	0	5	7
44	R:R:D406	R:R:N72	5.39	Yes	Yes	2	7	9
45	R:R:F407	R:R:N72	10.87	Yes	Yes	2	8	9
46	R:R:P150	R:R:Y73	5.56	No	No	0	5	6
47	R:R:D133	R:R:L74	5.43	No	No	0	9	8
48	R:R:L156	R:R:L74	4.15	No	No	0	6	8
49	R:R:I75	R:R:Y400	3.63	No	Yes	0	8	9
50	R:R:H126	R:R:S77	8.37	Yes	No	1	8	9
51	R:R:I157	R:R:S77	10.84	No	No	1	8	9
52	R:R:D82	R:R:L78	6.79	Yes	Yes	1	9	9
53	R:R:H126	R:R:L78	6.43	Yes	Yes	1	8	9
54	R:R:L127	R:R:L78	4.15	Yes	Yes	1	8	9
55	R:R:I130	R:R:L78	4.28	No	Yes	1	9	9
56	R:R:L78	R:R:N396	12.36	Yes	Yes	1	9	9
57	R:R:L78	R:R:Y400	4.69	Yes	Yes	1	9	9
58	R:R:S122	R:R:T81	6.4	No	No	1	8	9
59	R:R:H126	R:R:T81	12.32	Yes	No	1	8	9
60	R:R:T81	R:R:W161	9.7	No	Yes	1	9	9
61	R:R:D82	R:R:S123	7.36	Yes	No	0	9	9
62	R:R:D82	R:R:S393	4.42	Yes	No	0	9	9
63	R:R:D82	R:R:N396	8.08	Yes	Yes	1	9	9
64	R:R:M84	R:R:W161	5.82	No	Yes	0	7	9
65	R:R:S393	R:R:V85	4.85	No	No	0	9	8
66	R:R:L90	R:R:S86	6.01	Yes	No	0	8	8
67	R:R:L88	R:R:V87	5.96	No	No	0	6	6
68	R:R:L115	R:R:L88	5.54	No	No	0	5	6
69	R:R:D116	R:R:V89	5.84	Yes	No	1	8	8
70	R:R:V89	R:R:Y390	3.79	No	Yes	1	8	8
71	R:R:L90	R:R:W387	4.56	Yes	Yes	1	8	8
72	R:R:L90	R:R:Y390	8.21	Yes	Yes	1	8	8
73	R:R:M92	R:R:W102	4.65	No	Yes	0	6	9
74	R:R:F112	R:R:M92	16.17	No	No	0	6	6
75	R:R:A93	R:R:Y390	4	No	Yes	1	7	8
76	R:R:L95	R:R:L99	6.92	No	No	0	6	5
77	R:R:W102	R:R:Y96	6.75	Yes	No	1	9	6
78	R:R:A383	R:R:Q97	4.55	No	No	0	6	7
79	R:R:Q97	R:R:W387	4.38	No	Yes	0	7	8
80	R:R:D185	R:R:K101	4.15	No	No	0	4	5
81	R:R:L104	R:R:W102	9.11	No	Yes	1	7	9
82	R:R:T108	R:R:W102	4.85	No	Yes	1	6	9
83	R:R:C109	R:R:W102	7.84	No	Yes	1	9	9
84	R:R:C187	R:R:W102	11.75	No	Yes	1	9	9
85	R:R:L104	R:R:T108	5.9	No	No	1	7	6
86	R:R:D110	R:R:Q106	6.53	No	No	4	7	4
87	R:R:Q106	R:R:R176	7.01	No	No	4	4	6
88	R:R:C109	R:R:C187	7.28	No	No	1	9	9
89	R:R:D110	R:R:R176	4.76	No	No	4	7	6
90	R:R:I113	R:R:I189	4.42	No	No	1	7	6
91	R:R:A114	R:R:M172	4.83	No	No	0	7	6
92	R:R:C120	R:R:D116	4.67	No	Yes	1	7	8
93	R:R:D116	R:R:Y390	10.34	Yes	Yes	1	8	8
94	R:R:S168	R:R:V117	6.46	No	No	0	8	8
95	R:R:L118	R:R:W161	6.83	No	Yes	0	6	9
96	R:R:F165	R:R:L118	14.61	No	No	0	5	6
97	R:R:C120	R:R:W358	5.22	No	Yes	1	7	8
98	R:R:G164	R:R:T121	3.64	No	Yes	0	8	8
99	R:R:I167	R:R:T121	6.08	No	Yes	0	8	8
100	R:R:A203	R:R:T121	5.03	No	Yes	0	8	8
101	R:R:H126	R:R:S122	6.97	Yes	No	1	8	8
102	R:R:S122	R:R:W161	21	No	Yes	1	8	9
103	R:R:F354	R:R:I124	5.02	Yes	No	1	9	8
104	R:R:I124	R:R:W358	10.57	No	Yes	1	8	8
105	R:R:C128	R:R:W125	5.22	Yes	Yes	5	7	7
106	R:R:I163	R:R:W125	21.14	No	Yes	0	5	7
107	R:R:P207	R:R:W125	17.57	No	Yes	5	9	7
108	R:R:H126	R:R:I157	5.3	Yes	No	1	8	8
109	R:R:H126	R:R:T160	20.54	Yes	No	1	8	8
110	R:R:H126	R:R:W161	5.29	Yes	Yes	1	8	9
111	R:R:F354	R:R:L127	4.87	Yes	Yes	1	9	8
112	R:R:L127	R:R:N396	9.61	Yes	Yes	1	8	9
113	R:R:L127	R:R:Y400	5.86	Yes	Yes	1	8	9
114	R:R:C128	R:R:P207	3.77	Yes	No	5	7	9
115	R:R:C128	R:R:L210	6.35	Yes	No	0	7	7
116	R:R:C128	R:R:M211	8.1	Yes	Yes	0	7	9
117	R:R:A129	R:R:L156	6.3	No	No	0	8	6
118	R:R:I130	R:R:R134	7.52	No	No	1	9	9
119	R:R:I130	R:R:Y400	8.46	No	Yes	1	9	9
120	R:R:A131	R:R:M211	4.83	No	Yes	0	9	9
121	R:R:A131	R:R:Y215	6.67	No	Yes	0	9	9
122	R:R:L132	R:R:W136	15.94	No	No	0	6	5
123	R:R:L132	R:R:L214	6.92	No	No	0	6	7
124	R:R:D133	R:R:R148	13.1	No	Yes	3	9	8
125	R:R:R134	R:R:Y215	8.23	No	Yes	0	9	9
126	R:R:R134	R:R:Y400	6.17	No	Yes	1	9	9
127	R:R:W136	R:R:Y135	4.82	No	Yes	0	5	9
128	R:R:T139	R:R:Y135	14.98	No	Yes	0	8	9
129	R:R:L214	R:R:Y135	5.86	No	Yes	0	7	9
130	R:R:R217	R:R:Y135	17.49	No	Yes	0	7	9
131	R:R:I218	R:R:Y135	3.63	No	Yes	0	9	9
132	R:R:R152	R:R:W136	4	No	No	0	7	5
133	R:R:A137	R:R:Y144	4	No	No	0	8	8
134	R:R:I138	R:R:I218	4.42	No	No	0	9	9
135	R:R:D140	R:R:D143	7.98	No	No	0	7	6
136	R:R:D143	R:R:K147	6.91	No	No	0	6	5
137	R:R:D143	R:R:R152	11.91	No	No	0	6	7
138	R:R:R148	R:R:Y144	14.4	Yes	No	0	8	8
139	R:R:K147	R:R:N146	6.99	No	No	0	5	5
140	R:R:R148	R:R:R152	5.33	Yes	No	0	8	7
141	R:R:R151	R:R:T149	15.52	No	No	0	6	8
142	R:R:T160	R:R:W161	4.85	No	Yes	1	8	9
143	R:R:L162	R:R:L166	6.92	No	No	0	5	5
144	R:R:F165	R:R:I169	5.02	No	No	0	5	6
145	R:R:I167	R:R:Y198	6.04	No	Yes	0	8	5
146	R:R:I169	R:R:L173	4.28	No	No	0	6	6
147	R:R:P170	R:R:P171	5.84	No	No	0	8	7
148	R:R:P170	R:R:W175	9.46	No	No	6	8	6
149	R:R:P170	R:R:Y198	4.17	No	Yes	6	8	5
150	R:R:P171	R:R:Y195	18.08	No	Yes	0	7	8
151	R:R:W175	R:R:Y195	9.65	No	Yes	0	6	8
152	R:R:W175	R:R:Y198	7.72	No	Yes	6	6	5
153	R:R:S190	R:R:Y195	7.63	No	Yes	0	6	8
154	R:R:K191	R:R:P369	5.02	No	No	0	5	7
155	R:R:F370	R:R:H193	18.1	No	No	0	5	4
156	R:R:S199	R:R:Y195	11.45	No	Yes	0	8	8
157	R:R:P369	R:R:T196	12.24	No	No	0	7	7
158	R:R:F370	R:R:T196	3.89	No	No	0	5	7
159	R:R:F370	R:R:I197	5.02	No	No	0	5	7
160	R:R:T200	R:R:Y205	4.99	Yes	Yes	1	7	7
161	R:R:F362	R:R:T200	3.89	Yes	Yes	1	7	7
162	R:R:L366	R:R:T200	5.9	No	Yes	1	7	7
163	R:R:F201	R:R:Y205	11.35	No	Yes	0	5	7
164	R:R:F204	R:R:Y205	8.25	Yes	Yes	1	8	7
165	R:R:F204	R:R:L208	9.74	Yes	No	1	8	7
166	R:R:F204	R:R:F354	9.65	Yes	Yes	1	8	9
167	R:R:F204	R:R:W358	4.01	Yes	Yes	1	8	8
168	R:R:F204	R:R:L359	7.31	Yes	Yes	0	8	7
169	R:R:F204	R:R:F362	20.36	Yes	Yes	1	8	7
170	R:R:L366	R:R:Y205	5.86	No	Yes	1	7	7
171	R:R:L208	R:R:L212	5.54	No	No	0	7	6
172	R:R:F354	R:R:L208	4.87	Yes	No	1	9	7
173	R:R:M211	R:R:M351	7.22	Yes	No	0	9	8
174	R:R:F354	R:R:M211	7.46	Yes	Yes	0	9	9
175	R:R:L212	R:R:M351	4.24	No	No	0	6	8
176	R:R:R217	R:R:V213	3.92	No	No	0	7	5
177	R:R:I218	R:R:Y215	4.84	No	Yes	0	9	9
178	R:R:L347	R:R:Y215	5.86	No	Yes	0	8	9
179	R:R:I350	R:R:Y215	8.46	No	Yes	0	8	9
180	R:R:M351	R:R:Y215	4.79	No	Yes	0	8	9
181	R:R:R217	R:R:R220	7.46	No	No	0	7	5
182	R:R:F219	R:R:R223	20.31	No	Yes	0	6	7
183	R:R:F219	R:R:L347	3.65	No	No	0	6	8
184	R:R:R223	R:R:R227	6.4	Yes	No	7	7	6
185	R:R:E340	R:R:R223	16.28	Yes	Yes	7	8	7
186	R:R:R223	R:R:T343	3.88	Yes	No	0	7	8
187	R:R:F224	R:R:R225	6.41	No	No	8	6	7
188	R:R:F224	R:R:K228	7.44	No	No	8	6	5
189	R:R:K228	R:R:R225	9.9	No	No	8	5	7
190	R:R:I226	R:R:R339	5.01	No	No	0	6	7
191	R:R:E340	R:R:I226	6.83	Yes	No	0	8	6
192	R:R:E340	R:R:R227	15.12	Yes	No	7	8	6
193	R:R:E330	R:R:R333	10.47	No	No	0	4	4
194	R:R:M335	R:R:R339	11.17	No	No	0	4	7
195	R:R:I349	R:R:K345	4.36	No	No	0	7	7
196	R:R:I349	R:R:I399	4.42	No	No	0	7	8
197	R:R:F403	R:R:I349	3.77	No	No	0	8	7
198	R:R:I350	R:R:Y400	7.25	No	Yes	0	8	9
199	R:R:L395	R:R:T353	4.42	No	No	0	6	7
200	R:R:I399	R:R:T353	9.12	No	No	0	8	7
201	R:R:F354	R:R:W358	4.01	Yes	Yes	1	9	8
202	R:R:I355	R:R:L359	4.28	No	Yes	0	7	7
203	R:R:C357	R:R:N392	7.87	No	No	0	8	9
204	R:R:F361	R:R:W358	9.02	Yes	Yes	1	8	8
205	R:R:F362	R:R:W358	9.02	Yes	Yes	1	7	8
206	R:R:G389	R:R:W358	11.26	No	Yes	0	8	8
207	R:R:N392	R:R:W358	7.91	No	Yes	0	9	8
208	R:R:I363	R:R:L359	7.14	No	Yes	0	7	7
209	R:R:I385	R:R:P360	5.08	No	No	0	6	9
210	R:R:F361	R:R:F362	15	Yes	Yes	1	8	7
211	R:R:F361	R:R:N386	4.83	Yes	No	1	8	7
212	R:R:L368	R:R:V364	4.47	No	No	0	4	6
213	R:R:I385	R:R:V364	4.61	No	No	0	6	6
214	R:R:L368	R:R:M377	8.48	No	Yes	0	4	4
215	R:R:C371	R:R:C375	7.28	No	No	0	5	4
216	R:R:M377	R:R:P378	6.71	Yes	No	9	4	7
217	R:R:L381	R:R:M377	4.24	No	Yes	9	6	4
218	R:R:L381	R:R:P378	4.93	No	No	9	6	7
219	R:R:I384	R:R:L380	4.28	No	No	0	4	3
220	R:R:I385	R:R:L381	4.28	No	No	0	6	6
221	R:R:W387	R:R:Y390	15.43	Yes	Yes	1	8	8
222	R:R:N392	R:R:N396	12.26	No	Yes	0	9	9
223	R:R:P397	R:R:Y402	4.17	No	Yes	0	9	6
224	R:R:V398	R:R:Y402	5.05	No	Yes	0	6	6
225	R:R:F403	R:R:V398	5.24	No	No	0	8	6
226	R:R:I399	R:R:Y400	6.04	No	Yes	0	8	9
227	R:R:A401	R:R:F407	9.71	No	Yes	2	8	8
228	R:R:F411	R:R:Y402	10.32	No	Yes	0	8	6
229	R:R:D406	R:R:N404	14.81	Yes	No	2	7	9
230	R:R:F407	R:R:N404	7.25	Yes	No	2	8	9
231	R:R:D406	R:R:F407	5.97	Yes	Yes	2	7	8
232	R:R:K412	R:R:Q408	5.42	No	No	0	6	9
233	R:R:G76	R:R:I75	3.53	No	No	0	6	8
234	R:R:G202	R:R:I206	3.53	No	No	0	5	6
235	R:R:I206	R:R:W125	3.52	No	Yes	0	6	7
236	R:R:P150	R:R:T149	3.5	No	No	0	5	8
237	R:R:G382	R:R:M377	3.49	No	Yes	0	4	4
238	L:L:?1	R:R:T121	3.47	Yes	Yes	0	0	8
239	R:R:D192	R:R:Y195	3.45	No	Yes	0	6	8
240	R:R:C371	R:R:S374	3.44	No	No	0	5	5
241	R:R:A50	R:R:S86	3.42	No	No	0	8	8
242	R:R:C119	R:R:V85	3.42	No	No	0	7	8
243	R:R:A79	R:R:V57	3.39	No	Yes	0	9	9
244	R:R:A153	R:R:V70	3.39	No	Yes	0	7	7
245	R:R:A222	R:R:T343	3.36	No	No	0	8	8
246	R:R:D192	R:R:G194	3.35	No	No	0	6	5
247	R:R:L359	R:R:P360	3.28	Yes	No	0	7	9
248	R:R:S86	R:R:V51	3.23	No	No	0	8	7
249	R:R:D140	R:R:P141	3.22	No	No	0	7	8
250	R:R:V51	R:R:V87	3.21	No	No	0	7	6
251	R:R:C56	R:R:L52	3.17	No	No	0	8	4
252	R:R:A50	R:R:L394	3.15	No	No	0	8	7
253	R:R:A55	R:R:L83	3.15	No	No	0	5	8
254	R:R:T196	R:R:T200	3.14	No	Yes	0	7	7
255	R:R:M84	R:R:V80	3.04	No	No	0	7	7
256	R:R:L41	R:R:V37	2.98	No	No	0	4	5
257	R:R:N146	R:R:V145	2.96	No	No	0	5	6
258	R:R:L43	R:R:T39	2.95	No	No	0	7	5
259	R:R:Q36	R:R:V98	2.87	No	No	0	4	6
260	R:R:I414	R:R:L63	2.85	No	No	0	7	6
261	R:R:L95	R:R:M92	2.83	No	No	0	6	6
262	R:R:I142	R:R:N146	2.83	No	No	0	6	5
263	R:R:K413	R:R:N409	2.8	No	No	0	6	6
264	R:R:C56	R:R:F411	2.79	No	No	0	8	8
265	R:R:A365	R:R:F361	2.77	No	Yes	0	8	8
266	R:R:R176	R:R:S190	2.64	No	No	0	6	6
267	R:R:R223	R:R:V344	2.62	Yes	No	0	7	8
268	R:R:F48	R:R:L52	2.44	No	No	0	4	4
269	R:R:G105	R:R:T108	1.82	No	No	0	7	6
270	R:R:G44	R:R:I47	1.76	No	No	0	4	7
271	R:R:C357	R:R:S391	1.72	No	No	0	8	5
272	R:R:A114	R:R:S168	1.71	No	No	0	7	8
273	R:R:A155	R:R:S158	1.71	No	No	0	3	5
274	R:R:A221	R:R:T139	1.68	No	No	0	6	8
275	R:R:L388	R:R:P360	1.64	No	No	0	8	9
276	R:R:A336	R:R:I226	1.62	No	No	0	5	6
277	R:R:T39	R:R:V98	1.59	No	No	0	5	6
278	R:R:C375	R:R:L368	1.59	No	No	0	4	4
279	R:R:A59	R:R:L63	1.58	No	No	0	5	6
280	R:R:A71	R:R:N69	1.56	No	No	0	8	8
281	R:R:I363	R:R:V367	1.54	No	No	0	7	6
282	R:R:I350	R:R:T346	1.52	No	No	0	8	8
283	R:R:F219	R:R:G216	1.51	No	No	0	6	3
284	R:R:K342	R:R:T346	1.5	No	No	0	8	8
285	R:R:L99	R:R:T103	1.47	No	No	0	5	5
286	R:R:L104	R:R:T103	1.47	No	No	0	7	5
287	R:R:K405	R:R:N404	1.4	No	No	0	6	9
288	R:R:L159	R:R:L162	1.38	No	No	0	3	5
289	R:R:A329	R:R:R333	1.38	No	No	0	5	4
290	R:R:A338	R:R:R341	1.38	No	No	0	5	6
291	R:R:L356	R:R:L388	1.38	No	No	0	5	8
292	R:R:E64	R:R:I414	1.37	Yes	No	0	7	7
293	R:R:E64	R:R:K413	1.35	Yes	No	0	7	6
294	R:R:E330	R:R:K334	1.35	No	No	0	4	5
295	R:R:A186	R:R:Y96	1.33	No	No	0	4	6
296	R:R:E340	R:R:L337	1.33	Yes	No	0	8	5
297	R:R:S34	R:R:Y35	1.27	No	No	0	3	4
298	R:R:L337	R:R:R341	1.21	No	No	0	5	6
299	R:R:L166	R:R:Y198	1.17	No	Yes	0	5	5
300	R:R:E326	R:R:R323	1.16	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.56286	14	1	0
2	R:R:V57	4.68	4	2	9
3	R:R:E64	4.514	5	0	7
4	R:R:L67	6.8225	4	2	8
5	R:R:V70	7.5175	4	3	7
6	R:R:N72	8.5025	4	2	9
7	R:R:L78	6.45	6	1	9
8	R:R:D82	6.676	5	1	9
9	R:R:L90	6.835	4	1	8
10	R:R:W102	7.18857	7	1	9
11	R:R:D116	9.0125	4	1	8
12	R:R:T121	4.555	4	0	8
13	R:R:W125	11.8625	4	5	7
14	R:R:H126	9.31714	7	1	8
15	R:R:L127	6.1225	4	1	8
16	R:R:C128	5.86	4	5	7
17	R:R:Y135	9.356	5	0	9
18	R:R:R148	12.4575	4	3	8
19	R:R:W161	8.915	6	1	9
20	R:R:Y195	10.052	5	0	8
21	R:R:Y198	4.775	4	6	5
22	R:R:T200	4.48	4	1	7
23	R:R:F204	9.88667	6	1	8
24	R:R:Y205	7.6125	4	1	7
25	R:R:M211	6.9025	4	0	9
26	R:R:Y215	6.475	6	0	9
27	R:R:R223	9.898	5	7	7
28	R:R:E340	9.89	4	7	8
29	R:R:F354	5.98	6	1	9
30	R:R:W358	7.6275	8	1	8
31	R:R:L359	5.5025	4	0	7
32	R:R:F361	10.056	5	1	8
33	R:R:F362	11.09	5	1	7
34	R:R:M377	5.73	4	9	4
35	R:R:W387	10.3625	4	1	8
36	R:R:Y390	8.68833	6	1	8
37	R:R:N396	10.5775	4	1	9
38	R:R:Y400	6.01429	7	1	9
39	R:R:Y402	6.04	5	0	6
40	R:R:D406	7.9	4	2	7
41	R:R:F407	7.67857	7	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y390	51.9455	10.36	Yes	Yes	1	0	8
2	R:R:W387	R:R:Y390	24.8431	15.43	Yes	Yes	1	8	8
3	R:R:L43	R:R:W387	16.945	17.08	No	Yes	0	7	8
4	R:R:L43	R:R:T39	11.4223	2.95	No	No	0	7	5
5	R:R:L90	R:R:Y390	36.3818	8.21	Yes	Yes	1	8	8
6	R:R:L90	R:R:S86	25.5895	6.01	Yes	No	0	8	8
7	R:R:A50	R:R:S86	11.4223	3.42	No	No	0	8	8
8	L:L:?1	R:R:C120	33.9734	5.61	Yes	No	1	0	7
9	R:R:C120	R:R:W358	47.503	5.22	No	Yes	1	7	8
10	R:R:N392	R:R:W358	36.8119	7.91	No	Yes	0	9	8
11	R:R:N392	R:R:N396	36.5538	12.26	No	Yes	0	9	9
12	R:R:D82	R:R:N396	27.6488	8.08	Yes	Yes	1	9	9
13	R:R:D82	R:R:N54	41.8033	6.73	Yes	No	0	9	9
14	R:R:N54	R:R:P397	38.0313	8.15	No	No	0	9	9
15	R:R:P397	R:R:Y402	36.7765	4.17	No	Yes	0	9	6
16	L:L:?1	R:R:F361	34.1201	18.66	Yes	Yes	1	0	8
17	R:R:F361	R:R:W358	35.5748	9.02	Yes	Yes	1	8	8
18	L:L:?1	R:R:F362	72.2172	7.18	Yes	Yes	1	0	7
19	R:R:F362	R:R:W358	38.1375	9.02	Yes	Yes	1	7	8
20	R:R:V57	R:R:Y402	33.2397	6.31	Yes	Yes	0	9	6
21	R:R:F407	R:R:V57	28.3394	3.93	Yes	Yes	2	8	9
22	R:R:F354	R:R:W358	87.333	4.01	Yes	Yes	1	9	8
23	R:R:F354	R:R:L127	34.3276	4.87	Yes	Yes	1	9	8
24	R:R:L127	R:R:L78	17.2258	4.15	Yes	Yes	1	8	9
25	R:R:H126	R:R:L78	28.0839	6.43	Yes	Yes	1	8	9
26	R:R:H126	R:R:W161	15.9381	5.29	Yes	Yes	1	8	9
27	R:R:F204	R:R:F362	41.1227	20.36	Yes	Yes	1	8	7
28	R:R:F204	R:R:F354	41.3277	9.65	Yes	Yes	1	8	9
29	R:R:L78	R:R:N396	11.1921	12.36	Yes	Yes	1	9	9
30	R:R:F407	R:R:L67	15.1159	9.74	Yes	Yes	2	8	8
31	R:R:E64	R:R:L67	13.5777	6.63	Yes	Yes	0	7	8
32	R:R:F354	R:R:M211	100	7.46	Yes	Yes	0	9	9
33	R:R:A131	R:R:M211	46.7441	4.83	No	Yes	0	9	9
34	R:R:A131	R:R:Y215	46.3545	6.67	No	Yes	0	9	9
35	R:R:I218	R:R:Y215	94.6317	4.84	No	Yes	0	9	9
36	R:R:I218	R:R:Y135	89.3746	3.63	No	Yes	0	9	9
37	R:R:W136	R:R:Y135	68.0783	4.82	No	Yes	0	5	9
38	R:R:R152	R:R:W136	62.7833	4	No	No	0	7	5
39	R:R:R148	R:R:R152	41.4364	5.33	Yes	No	0	8	7
40	R:R:R148	R:R:V70	22.159	17	Yes	Yes	3	8	7
41	R:R:P150	R:R:V70	16.7097	5.3	No	Yes	0	5	7
42	R:R:M211	R:R:M351	46.7618	7.22	Yes	No	0	9	8
43	R:R:M351	R:R:Y215	59.912	4.79	No	Yes	0	8	9
44	R:R:F204	R:R:L208	14.0761	9.74	Yes	No	1	8	7
45	R:R:L208	R:R:L212	14.2051	5.54	No	No	0	7	6
46	R:R:L212	R:R:M351	13.8408	4.24	No	No	0	6	8
47	R:R:D133	R:R:R148	11.0782	13.1	No	Yes	3	9	8
48	R:R:L127	R:R:Y400	14.5568	5.86	Yes	Yes	1	8	9
49	R:R:S86	R:R:V51	11.4223	3.23	No	No	0	8	7
50	L:L:?1	R:R:W102	25.2555	5.37	Yes	Yes	1	0	9
51	L:L:?1	R:R:T121	43.3313	3.47	Yes	Yes	0	0	8
52	R:R:I167	R:R:T121	36.6373	6.08	No	Yes	0	8	8
53	R:R:I167	R:R:Y198	34.4819	6.04	No	Yes	0	8	5
54	R:R:W175	R:R:Y198	20.7448	7.72	No	Yes	6	6	5
55	R:R:W175	R:R:Y195	18.473	9.65	No	Yes	0	6	8
56	R:R:R134	R:R:Y400	14.324	6.17	No	Yes	1	9	9
57	R:R:D143	R:R:R152	19.4748	11.91	No	No	0	6	7
58	R:R:D143	R:R:K147	11.1592	6.91	No	No	0	6	5
59	R:R:T196	R:R:T200	11.0175	3.14	No	Yes	0	7	7
60	R:R:F204	R:R:L359	17.8886	7.31	Yes	Yes	0	8	7
61	R:R:L347	R:R:Y215	43.86	5.86	No	Yes	0	8	9
62	R:R:I350	R:R:Y400	16.5402	7.25	No	Yes	0	8	9
63	R:R:F219	R:R:L347	41.1379	3.65	No	No	0	6	8
64	R:R:F219	R:R:R223	35.6785	20.31	No	Yes	0	6	7
65	R:R:E340	R:R:R223	21.9161	16.28	Yes	Yes	7	8	7
66	R:R:E340	R:R:I226	11.1491	6.83	Yes	No	0	8	6
67	R:R:I399	R:R:Y400	16.6135	6.04	No	Yes	0	8	9
68	R:R:I349	R:R:I399	13.0768	4.42	No	No	0	7	8
69	R:R:F403	R:R:I349	10.7139	3.77	No	No	0	8	7
70	R:R:L359	R:R:P360	13.8105	3.28	Yes	No	0	7	9
71	R:R:I385	R:R:P360	10.6987	5.08	No	No	0	6	9
72	R:R:D116	R:R:Y390	12.0547	10.34	Yes	Yes	1	8	8
73	R:R:C120	R:R:D116	13.1552	4.67	No	Yes	1	7	8
74	R:R:D82	R:R:L78	20.3754	6.79	Yes	Yes	1	9	9
75	R:R:R134	R:R:Y215	21.0787	8.23	No	Yes	0	9	9
76	R:R:L78	R:R:Y400	16.3909	4.69	Yes	Yes	1	9	9
77	R:R:I350	R:R:Y215	13.7776	8.46	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A93	4.64	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y96	7.6	1	Yes	No	0	6	0	1
L:L:?1	R:R:W102	5.37	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:I113	6.73	1	Yes	No	0	7	0	1
L:L:?1	R:R:D116	15.2	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V117	10.54	1	Yes	No	0	8	0	1
L:L:?1	R:R:C120	5.61	1	Yes	No	0	7	0	1
L:L:?1	R:R:C187	4.68	1	Yes	No	0	9	0	1
L:L:?1	R:R:I189	10.94	1	Yes	No	0	6	0	1
L:L:?1	R:R:F361	18.66	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F362	7.18	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N386	8.9	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y390	10.36	1	Yes	Yes	0	8	0	1
R:R:D116	R:R:V89	5.84	1	Yes	No	8	8	1	2
R:R:V89	R:R:Y390	3.79	1	No	Yes	8	8	2	1
R:R:L90	R:R:W387	4.56	1	Yes	Yes	8	8	2	2
R:R:L90	R:R:Y390	8.21	1	Yes	Yes	8	8	2	1
R:R:M92	R:R:W102	4.65	0	No	Yes	6	9	2	1
R:R:A93	R:R:Y390	4	1	No	Yes	7	8	1	1
R:R:W102	R:R:Y96	6.75	1	Yes	No	9	6	1	1
R:R:L104	R:R:W102	9.11	1	No	Yes	7	9	2	1
R:R:T108	R:R:W102	4.85	1	No	Yes	6	9	2	1
R:R:C109	R:R:W102	7.84	1	No	Yes	9	9	2	1
R:R:C187	R:R:W102	11.75	1	No	Yes	9	9	1	1
R:R:L104	R:R:T108	5.9	1	No	No	7	6	2	2
R:R:C109	R:R:C187	7.28	1	No	No	9	9	2	1
R:R:I113	R:R:I189	4.42	1	No	No	7	6	1	1
R:R:C120	R:R:D116	4.67	1	No	Yes	7	8	1	1
R:R:D116	R:R:Y390	10.34	1	Yes	Yes	8	8	1	1
R:R:S168	R:R:V117	6.46	0	No	No	8	8	2	1
R:R:C120	R:R:W358	5.22	1	No	Yes	7	8	1	2
R:R:G164	R:R:T121	3.64	0	No	Yes	8	8	2	1
R:R:I167	R:R:T121	6.08	0	No	Yes	8	8	2	1
R:R:A203	R:R:T121	5.03	0	No	Yes	8	8	2	1
R:R:F362	R:R:T200	3.89	1	Yes	Yes	7	7	1	2
R:R:F204	R:R:W358	4.01	1	Yes	Yes	8	8	2	2
R:R:F204	R:R:F362	20.36	1	Yes	Yes	8	7	2	1
R:R:F361	R:R:W358	9.02	1	Yes	Yes	8	8	1	2
R:R:F362	R:R:W358	9.02	1	Yes	Yes	7	8	1	2
R:R:F361	R:R:F362	15	1	Yes	Yes	8	7	1	1
R:R:F361	R:R:N386	4.83	1	Yes	No	8	7	1	1
R:R:W387	R:R:Y390	15.43	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:T121	3.47	1	Yes	Yes	0	8	0	1
R:R:A365	R:R:F361	2.77	0	No	Yes	8	8	2	1
R:R:A186	R:R:Y96	1.33	0	No	No	4	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9VJ6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	258
Number of Links	300
Number of Hubs	41
Number of Links mediated by Hubs	165
Number of Communities	9
Number of Nodes involved in Communities	69
Number of Links involved in Communities	102

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	97059
Length Of Smallest Path	3
Average Path Length	13.3677
Length of Longest Path	25
Minimum Path Strength	1.27
Average Path Strength	6.97319
Maximum Path Strength	19.355
Minimum Path Correlation	0.7
Average Path Correlation	0.938647
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	54.2602
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.4886
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • protein binding • signaling receptor binding • receptor-receptor interaction • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • behavior • multicellular organismal process • exploration behavior • regulation of amine metabolic process • dopamine metabolic process • primary metabolic process • catechol-containing compound metabolic process • regulation of primary metabolic process • amine metabolic process • catecholamine metabolic process • phenol-containing compound metabolic process • metabolic process • regulation of catecholamine metabolic process • regulation of metabolic process • biogenic amine metabolic process • regulation of dopamine metabolic process • adult behavior • regulation of tube diameter • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cell-cell signaling • gamma-aminobutyric acid signaling pathway • regulation of behavior • serotonin metabolic process • indole-containing compound metabolic process • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • response to chemical • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • monoamine transport • nitrogen compound transport • organic hydroxy compound transport • monoatomic ion transport • serotonin secretion • regulation of monoatomic ion transport • regulation of serotonin secretion • serotonin transport • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • behavioral defense response • fear response • behavioral fear response • defense response • response to stress • multicellular organismal response to stress • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • electron transport chain • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • synapse • cell junction • periplasmic space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • GDP binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • cell division • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • positive regulation of autophagy • catabolic process • macroautophagy • autophagy • regulation of catabolic process • regulation of autophagy • positive regulation of catabolic process • positive regulation of metabolic process • regulation of macroautophagy • positive regulation of macroautophagy • process utilizing autophagic mechanism • nucleoside phosphate metabolic process • ribose phosphate metabolic process • purine nucleoside triphosphate metabolic process • GTP metabolic process • carbohydrate derivative metabolic process • nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • nucleoside triphosphate metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08908
Sequence	>9VJ6_nogp_Chain_R S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E R S L Q N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N K W T L G Q V T C D L F I A L D V L C C T S S I H L C A I A L D R Y W A I T D P I D Y V N K R T P R R A A A L I S L T W L I G F L I S I P P M L G W R P D A C T I S K D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K R K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C E S S C H M P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F Q N A F K K I W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E2X	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2X (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	-	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P	Gi1/β1/γ2	3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Y (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Serotonin	PtdIns4P		3	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P	Gi1/β1/γ2	3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	7E2Z (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Aripiprazole	PtdIns4P		3.1	2021-04-14	doi.org/10.1038/s41586-021-03376-8
	8JSP	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-	Gi1/β1/γ2	3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSP (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Ulotaront	-		3.65	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W8B	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-	Gi1/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8B (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	SEP-363856	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8FY8	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ1	2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FY8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.79	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P	Gi1/β1/γ1	2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	4-F,5-MeO-PyrT	PtdIns4P		2.85	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P	Gi1/β1/γ1	2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Vilazodone	PtdIns4P		2.94	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P	Gi1/β1/γ1	2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYT (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	LSD	PtdIns4P		2.64	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gi1/β1/γ1	2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8FYX (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.72	2024-05-15	doi.org/10.1038/s41586-024-07403-2
	8PJK	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-	Gi1/β1/γ1	2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PJK (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	ST171	-		2.4	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gi1/β1/γ1	2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8PKM (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		2.9	2024-05-29	doi.org/10.1126/sciadv.adv9267
	8JT6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P	Gi1/β1/γ2	3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	8JT6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	(R)-IHCH-7179	PtdIns4P		3	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9GL2	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-	Gs/β1/γ2	3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9GL2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Befiradol	-		3.2	2025-07-02	doi.org/10.1126/sciadv.adv9267
	9DYD	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Go/β1/γ2	2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.96	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Go/β1/γ2	2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		2.9	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P	Gi1/β1/γ2	2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9DYF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Asenapine	PtdIns4P		2.74	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P	Gz/β1/γ2	3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9MD1 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	PtdIns4P		3.03	2025-08-13	doi.org/10.1126/sciadv.adu9851
	9VJ5	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-	Go/β1/γ2	2.69	2025-11-12	To be published
	9VJ5 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Gepirone	-		2.69	2025-11-12	To be published
	9VJ6	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-	Gi3/β1/γ2	2.62	2025-11-12	To be published
	9VJ6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	F-15599	-		2.62	2025-11-12	To be published
	9VJE	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Go/β1/γ2	2.47	2025-11-12	To be published
	9VJE (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.47	2025-11-12	To be published
	9VJF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-	Gi3/β1/γ2	2.7	2025-11-12	To be published
	9VJF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Buspirone	-		2.7	2025-11-12	To be published
	9VJG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-	chim(NtGi2-Gz)/β1/γ2	2.67	2025-11-12	To be published
	9VJG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	8-OH-DPAT	-		2.67	2025-11-12	To be published
	9VMY	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-	Go/β1/γ2	2.86	2025-11-12	To be published
	9VMY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	TMU4142	-		2.86	2025-11-12	To be published
	9VNF	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-	Go/β1/γ2	2.74	2025-11-12	To be published
	9VNF (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Pindolol	-		2.74	2025-11-12	To be published
	9KVG	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P	Gi1/β1/γ2	2.63	2025-12-03	To be published
	9KVG (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	5-MeO-DMT	PtdIns4P		2.63	2025-12-03	To be published
	9KVH	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P	Gi1/β1/γ2	2.59	2025-12-03	To be published
	9KVH (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Cinobufotenine	PtdIns4P		2.59	2025-12-03	To be published
	9KVI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P	Gi1/β1/γ2	2.54	2025-12-03	To be published
	9KVI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	Bufotenin	PtdIns4P		2.54	2025-12-03	To be published
	9HYI	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-	Gi1/β1/γ2	2.3	2026-01-21	To be published
	9HYI (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1A	Homo sapiens	DP81	-		2.3	2026-01-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9VJ6_nogp.zip

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